                         SEQUENCE LISTING

<110>  THE CATHOLIC UNIVERSITY OF AMERICA
 
<120>  DESIGN OF BACTERIOPHAGE-BASED ARTIFICIAL VIRUSES FOR HUMAN GENOME
        REMODELING

<130>  109007-23787US01

<150>  US 63/058,012
<151>  2020-07-29

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: DNA template for AAVS1gRNA in vitro synthesis

<400>  1
aagcaatacg actcactata ggggccacta gggacaggat gttttagagc tagaaatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt      120


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAVS1-Cas9-gRNA1

<400>  2
gtcccctcca ccccacagtg                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAVS1-Cas9-gRNA2

<400>  3
ggggccacta gggacaggat                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: HBB-Cas9-gRNA

<400>  4
agtctgccgt tactgccctg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ipIII-Cas9-gRNA

<400>  5
ggcctttact acagaagctt                                                   20


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ipI-Cpf1- gRNA1

<400>  6
ttcagcagga gagataacga ttg                                               23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ipI-Cpf1-gRNA2

<400>  7
taccattacc gaagctactc tta                                               23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ipII-Cpf1-gRNA1

<400>  8
cttctaagtt cggcatgtct atg                                               23


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ipII-Cpf1-gRNA2

<400>  9
ttacggtctt tatcgggcaa                                                   20


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ipIII-Cpf1-gRNA1

<400>  10
aagtcggaag cctttgtagc taa                                               23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ipIII-Cpf1-gRNA2

<400>  11
tgcttggcaa attcaagacc tgc                                               23


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: P1

<400>  12
ctgccgtctc tctcctgagt                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: P2

<400>  13
gtgggcttgt actcggtcat                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: P3

<400>  14
aaaactgacg cacggaggaa                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: P4

<400>  15
gtggattcgg gtcacctctc                                                   20


<210>  16
<211>  1462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cas9-Soc

<400>  16

Pro Lys Lys Lys Arg Lys Val Met Asp Lys Lys Tyr Ser Ile Gly Leu 
1               5                   10                  15      


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            20                  25                  30          


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        35                  40                  45              


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    50                  55                  60                  


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
65                  70                  75                  80  


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                85                  90                  95      


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            100                 105                 110         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        115                 120                 125             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile His Leu 
    130                 135                 140                 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
145                 150                 155                 160 


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
                165                 170                 175     


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
            180                 185                 190         


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
        195                 200                 205             


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
    210                 215                 220                 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
                245                 250                 255     


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
            260                 265                 270         


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
        275                 280                 285             


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
    290                 295                 300                 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
305                 310                 315                 320 


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
                325                 330                 335     


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
            340                 345                 350         


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
    370                 375                 380                 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
385                 390                 395                 400 


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
                405                 410                 415     


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
            420                 425                 430         


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
        435                 440                 445             


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
    450                 455                 460                 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
465                 470                 475                 480 


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
                485                 490                 495     


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
    530                 535                 540                 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
545                 550                 555                 560 


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
                565                 570                 575     


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
            580                 585                 590         


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
        595                 600                 605             


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
    610                 615                 620                 


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
625                 630                 635                 640 


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
                645                 650                 655     


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
            660                 665                 670         


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
        675                 680                 685             


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
    690                 695                 700                 


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
705                 710                 715                 720 


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
                725                 730                 735     


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
            740                 745                 750         


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
        755                 760                 765             


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
    770                 775                 780                 


Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln 
785                 790                 795                 800 


Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys 
                805                 810                 815     


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln 
            820                 825                 830         


Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val 
        835                 840                 845             


Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr 
    850                 855                 860                 


Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu 
865                 870                 875                 880 


Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys 
                885                 890                 895     


Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg 
    930                 935                 940                 


Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys 
945                 950                 955                 960 


Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe 
                965                 970                 975     


Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1010                 1015                 1020             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1055                 1060                 1065             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1070                 1075                 1080             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1115                 1120                 1125             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1130                 1135                 1140             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1145                 1150                 1155             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1160                 1165                 1170             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1175                 1180                 1185             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1190                 1195                 1200             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1205                 1210                 1215             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1220                 1225                 1230             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1235                 1240                 1245             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1250                 1255                 1260             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1265                 1270                 1275             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1280                 1285                 1290             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1295                 1300                 1305             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1310                 1315                 1320             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1325                 1330                 1335             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1340                 1345                 1350             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Gln Leu  Gly Gly Asp Gly Gly  Gly Gly Ser Arg Ser  Gly Gly Tyr 
    1370                 1375                 1380             


Val Asn  Ile Lys Thr Phe Thr  His Pro Ala Gly Glu  Gly Lys Glu 
    1385                 1390                 1395             


Val Lys  Gly Met Glu Val Ser  Val Pro Phe Glu Ile  Tyr Ser Asn 
    1400                 1405                 1410             


Glu His  Arg Ile Ala Asp Ala  His Tyr Gln Thr Phe  Pro Ser Glu 
    1415                 1420                 1425             


Lys Ala  Ala Tyr Thr Val Val  Thr Asp Ala Ala Asp  Trp Arg Thr 
    1430                 1435                 1440             


Lys Asn  Ala Ala Met Phe Thr  Pro Thr Pro Val Ser  Gly His His 
    1445                 1450                 1455             


His His  His His 
    1460         


<210>  17
<211>  1334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cpf1-Soc

<400>  17

Pro Lys Lys Lys Arg Lys Val Met Ser Lys Leu Glu Lys Phe Thr Asn 
1               5                   10                  15      


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
            20                  25                  30          


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
        35                  40                  45              


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
    50                  55                  60                  


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
65                  70                  75                  80  


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
                85                  90                  95      


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
            100                 105                 110         


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
        115                 120                 125             


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
    130                 135                 140                 


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
145                 150                 155                 160 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
                165                 170                 175     


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
            180                 185                 190         


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
        195                 200                 205             


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
    210                 215                 220                 


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
225                 230                 235                 240 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
                245                 250                 255     


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            260                 265                 270         


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
        275                 280                 285             


Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp 
    290                 295                 300                 


Glu Glu Val Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile 
305                 310                 315                 320 


Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu 
                325                 330                 335     


Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr 
            340                 345                 350         


Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp 
        355                 360                 365             


Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr 
    370                 375                 380                 


Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser 
385                 390                 395                 400 


Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val 
                405                 410                 415     


Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr 
            420                 425                 430         


Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu 
        435                 440                 445             


Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp 
    450                 455                 460                 


Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe 
465                 470                 475                 480 


Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe 
                485                 490                 495     


Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala 
            500                 505                 510         


Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys 
        515                 520                 525             


Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys 
    530                 535                 540                 


Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr 
545                 550                 555                 560 


Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp 
                565                 570                 575     


Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu 
            580                 585                 590         


Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp 
        595                 600                 605             


Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn 
    610                 615                 620                 


Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys 
625                 630                 635                 640 


Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser 
                645                 650                 655     


Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile 
            660                 665                 670         


Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe 
        675                 680                 685             


Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys 
    690                 695                 700                 


Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His 
705                 710                 715                 720 


Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu 
                725                 730                 735     


Asn Asn His Gly Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met 
            740                 745                 750         


Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn 
        755                 760                 765             


Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr 
    770                 775                 780                 


Leu Ser Tyr Asp Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr 
785                 790                 795                 800 


Glu Leu His Ile Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe 
                805                 810                 815     


Lys Ile Asn Thr Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro 
            820                 825                 830         


Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val 
        835                 840                 845             


Val Val Asp Gly Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu 
    850                 855                 860                 


Ile Ile Asn Asn Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser 
865                 870                 875                 880 


Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp 
                885                 890                 895     


Thr Ser Ile Glu Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln 
            900                 905                 910         


Val Val His Lys Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile 
        915                 920                 925             


Ala Leu Glu Asp Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val 
    930                 935                 940                 


Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu 
945                 950                 955                 960 


Asn Tyr Met Val Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala 
                965                 970                 975     


Leu Lys Gly Tyr Gln Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met 
            980                 985                 990         


Ser Thr Gln Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
        995                 1000                 1005             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1010                 1015                 1020             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1025                 1030                 1035             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1040                 1045                 1050             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1055                 1060                 1065             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1070                 1075                 1080             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1085                 1090                 1095             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1100                 1105                 1110             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1115                 1120                 1125             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1130                 1135                 1140             


Arg Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1145                 1150                 1155             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1160                 1165                 1170             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1175                 1180                 1185             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1190                 1195                 1200             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1205                 1210                 1215             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1220                 1225                 1230             


His Ala  Ala Ala Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Arg 
    1235                 1240                 1245             


Ser Gly  Gly Tyr Val Asn Ile  Lys Thr Phe Thr His  Pro Ala Gly 
    1250                 1255                 1260             


Glu Gly  Lys Glu Val Lys Gly  Met Glu Val Ser Val  Pro Phe Glu 
    1265                 1270                 1275             


Ile Tyr  Ser Asn Glu His Arg  Ile Ala Asp Ala His  Tyr Gln Thr 
    1280                 1285                 1290             


Phe Pro  Ser Glu Lys Ala Ala  Tyr Thr Thr Val Val  Thr Asp Ala 
    1295                 1300                 1305             


Ala Asp  Trp Arg Thr Lys Asn  Ala Ala Met Phe Thr  Pro Thr Pro 
    1310                 1315                 1320             


Val Ser  Gly Leu Glu His His  His His His His 
    1325                 1330                 


<210>  18
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cre-Hoc

<400>  18

Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe 
    50                  55                  60                  


Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala 
65                  70                  75                  80  


Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn 
                85                  90                  95      


Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala 
            100                 105                 110         


Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly 
        115                 120                 125             


Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln 
    130                 135                 140                 


Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn 
145                 150                 155                 160 


Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu 
                165                 170                 175     


Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg 
            180                 185                 190         


Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly 
        195                 200                 205             


Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp 
    210                 215                 220                 


Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys 
225                 230                 235                 240 


Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu 
                245                 250                 255     


Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile 
            260                 265                 270         


Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly 
        275                 280                 285             


His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val 
    290                 295                 300                 


Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile 
305                 310                 315                 320 


Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val 
                325                 330                 335     


Arg Leu Leu Glu Asp Gly Asp Gly Gly Ser Glu Phe Gly Gly Ser Gly 
            340                 345                 350         


Gly Ser Gly Gly Ser Gly Gly Ser Phe Thr Val Asp Ile Thr Pro Lys 
        355                 360                 365             


Thr Pro Thr Gly Val Ile Asp Glu Thr Lys Gln Phe Thr Ala Thr Pro 
    370                 375                 380                 


Ser Gly Gln Thr Gly Gly Gly Thr Ile Thr Tyr Ala Trp Ser Val Asp 
385                 390                 395                 400 


Asn Val Pro Gln Asp Gly Ala Glu Ala Thr Phe Ser Tyr Val Leu Lys 
                405                 410                 415     


Gly Pro Ala Gly Gln Lys Thr Ile Lys Val Val Ala Thr Asn Thr Leu 
            420                 425                 430         


Ser Glu Gly Gly Pro Glu Thr Ala Glu Ala Thr Thr Thr Ile Thr Val 
        435                 440                 445             


Lys Asn Lys Thr Gln Thr Thr Thr Leu Ala Val Thr Pro Ala Ser Pro 
    450                 455                 460                 


Ala Ala Gly Val Ile Gly Thr Pro Val Gln Phe Thr Ala Ala Leu Ala 
465                 470                 475                 480 


Ser Gln Pro Asp Gly Ala Ser Ala Thr Tyr Gln Trp Tyr Val Asp Asp 
                485                 490                 495     


Ser Gln Val Gly Gly Glu Thr Asn Ser Thr Phe Ser Tyr Thr Pro Thr 
            500                 505                 510         


Thr Ser Gly Val Lys Arg Ile Lys Cys Val Ala Gln Val Thr Ala Thr 
        515                 520                 525             


Asp Tyr Asp Ala Leu Ser Val Thr Ser Asn Glu Val Ser Leu Thr Val 
    530                 535                 540                 


Asn Lys Lys Thr Met Asn Pro Gln Val Thr Leu Thr Pro Pro Ser Ile 
545                 550                 555                 560 


Asn Val Gln Gln Asp Ala Ser Ala Thr Phe Thr Ala Asn Val Thr Gly 
                565                 570                 575     


Ala Pro Glu Glu Ala Gln Ile Thr Tyr Ser Trp Lys Lys Asp Ser Ser 
            580                 585                 590         


Pro Val Glu Gly Ser Thr Asn Val Tyr Thr Val Asp Thr Ser Ser Val 
        595                 600                 605             


Gly Ser Gln Thr Ile Glu Val Thr Ala Thr Val Thr Ala Ala Asp Tyr 
    610                 615                 620                 


Asn Pro Val Thr Val Thr Lys Thr Gly Asn Val Thr Val Thr Ala Lys 
625                 630                 635                 640 


Val Ala Pro Glu Pro Glu Gly Glu Leu Pro Tyr Val His Pro Leu Pro 
                645                 650                 655     


His Arg Ser Ser Ala Tyr Ile Trp Cys Gly Trp Trp Val Met Asp Glu 
            660                 665                 670         


Ile Gln Lys Met Thr Glu Glu Gly Lys Asp Trp Lys Thr Asp Asp Pro 
        675                 680                 685             


Asp Ser Lys Tyr Tyr Leu His Arg Tyr Thr Leu Gln Lys Met Met Lys 
    690                 695                 700                 


Asp Tyr Pro Glu Val Asp Val Gln Glu Ser Arg Asn Gly Tyr Ile Ile 
705                 710                 715                 720 


His Lys Thr Ala Leu Glu Thr Gly Ile Ile Tyr Thr Tyr Pro Gly Ser 
                725                 730                 735     


His His His His His His 
            740         


<210>  19
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: RGD-Hoc

<400>  19

Cys Asp Cys Arg Gly Asp Cys Phe Cys Ser Ala Met Thr Phe Thr Val 
1               5                   10                  15      


Asp Ile Thr Pro Lys Thr Pro Thr Gly Val Ile Asp Glu Thr Lys Gln 
            20                  25                  30          


Phe Thr Ala Thr Pro Ser Gly Gln Thr Gly Gly Gly Thr Ile Thr Tyr 
        35                  40                  45              


Ala Trp Ser Val Asp Asn Val Pro Gln Asp Gly Ala Glu Ala Thr Phe 
    50                  55                  60                  


Ser Tyr Val Leu Lys Gly Pro Ala Gly Gln Lys Thr Ile Lys Val Val 
65                  70                  75                  80  


Ala Thr Asn Thr Leu Ser Glu Gly Gly Pro Glu Thr Ala Glu Ala Thr 
                85                  90                  95      


Thr Thr Ile Thr Val Lys Asn Lys Thr Gln Thr Thr Thr Leu Ala Val 
            100                 105                 110         


Thr Pro Ala Ser Pro Ala Ala Gly Val Ile Gly Thr Pro Val Gln Phe 
        115                 120                 125             


Thr Ala Ala Leu Ala Ser Gln Pro Asp Gly Ala Ser Ala Thr Tyr Gln 
    130                 135                 140                 


Trp Tyr Val Asp Asp Ser Gln Val Gly Gly Glu Thr Asn Ser Thr Phe 
145                 150                 155                 160 


Ser Tyr Thr Pro Thr Thr Ser Gly Val Lys Arg Ile Lys Cys Val Ala 
                165                 170                 175     


Gln Val Thr Ala Thr Asp Tyr Asp Ala Leu Ser Val Thr Ser Asn Glu 
            180                 185                 190         


Val Ser Leu Thr Val Asn Lys Lys Thr Met Asn Pro Gln Val Thr Leu 
        195                 200                 205             


Thr Pro Pro Ser Ile Asn Val Gln Gln Asp Ala Ser Ala Thr Phe Thr 
    210                 215                 220                 


Ala Asn Val Thr Gly Ala Pro Glu Glu Ala Gln Ile Thr Tyr Ser Trp 
225                 230                 235                 240 


Lys Lys Asp Ser Ser Pro Val Glu Gly Ser Thr Asn Val Tyr Thr Val 
                245                 250                 255     


Asp Thr Ser Ser Val Gly Ser Gln Thr Ile Glu Val Thr Ala Thr Val 
            260                 265                 270         


Thr Ala Ala Asp Tyr Asn Pro Val Thr Val Thr Lys Thr Gly Asn Val 
        275                 280                 285             


Thr Val Thr Ala Lys Val Ala Pro Glu Pro Glu Gly Glu Leu Pro Tyr 
    290                 295                 300                 


Val His Pro Leu Pro His Arg Ser Ser Ala Tyr Ile Trp Cys Gly Trp 
305                 310                 315                 320 


Trp Val Met Asp Glu Ile Gln Lys Met Thr Glu Glu Gly Lys Asp Trp 
                325                 330                 335     


Lys Thr Asp Asp Pro Asp Ser Lys Tyr Tyr Leu His Arg Tyr Thr Leu 
            340                 345                 350         


Gln Lys Met Met Lys Asp Tyr Pro Glu Val Asp Val Gln Glu Ser Arg 
        355                 360                 365             


Asn Gly Tyr Ile Ile His Lys Thr Ala Leu Glu Thr Gly Ile Ile Tyr 
    370                 375                 380                 


Thr Tyr Pro Lys Leu Ala Ala Ala Leu Glu His His His His His His 
385                 390                 395                 400 


<210>  20
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CTS-LacI-NLS

<400>  20

Met Lys Thr Tyr Gln Glu Phe Ile Ala Glu Met Lys Tyr Val Thr Leu 
1               5                   10                  15      


Tyr Asp Val Ala Glu Tyr Ala Gly Val Ser His Gln Thr Val Ser Arg 
            20                  25                  30          


Val Val Asn Gln Ala Ser His Val Ser Ala Lys Thr Arg Glu Lys Val 
        35                  40                  45              


Glu Ala Ala Met Ala Glu Leu Asn Tyr Ile Pro Asn Arg Val Ala Gln 
    50                  55                  60                  


Gln Leu Ala Gly Lys Gln Ser Leu Leu Ile Lys Arg Pro Ala Ala Thr 
65                  70                  75                  80  


Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
                85                  90  


<210>  21
<211>  6806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: streptomycin-resistant plasmid DS-SPCas

<400>  21
accaggcacg cctaaccgtc agtgagattg gatgagtgaa cgatattgat cgagaagagc       60

cctgcgcagc cgctgccgtg cctgcaggaa gcaacggccc ggagggtggc gggcaggacg      120

cccgccataa actgccaggc atcaaattaa gcagaaggcc atcctgacgg atggcctttt      180

tgcgtttcta caaactctgc tagcttctag agcacagcta acaccacgtc gtccctatct      240

gctgccctag gtctatgagt ggttgctgga taactttacg ggcatgcata aggctcgtat      300

gatatattca gggagaccac aacggtttcc ctctacaaat aattttgttt aacttttact      360

agaggaggag gcaaaaatgg ataagaaata ctcaataggc ttagatatcg gcacaaatag      420

cgtcggatgg gcggtgatca ctgatgaata taaggttccg tctaaaaagt tcaaggttct      480

gggaaataca gaccgccaca gtatcaaaaa aaatcttata ggggctcttt tatttgacag      540

tggagagaca gcggaagcga ctcgtctcaa acggacagct cgtagaaggt atacacgtcg      600

gaagaatcgt atttgttatc tacaggagat tttttcaaat gagatggcga aagtagatga      660

tagtttcttt catcgacttg aagagtcttt tttggtggaa gaagacaaga agcatgaacg      720

tcatcctatt tttggaaata tagtagatga agttgcttat catgagaaat atccaactat      780

ctatcatctg cgaaaaaaat tggtagattc tactgataaa gcggatttgc gcttaatcta      840

tttggcctta gcgcatatga ttaagtttcg tggtcatttt ttgattgagg gagatttaaa      900

tcctgataat agtgatgtgg acaaactatt tatccagttg gtacaaacct acaatcaatt      960

atttgaagaa aaccctatta acgcaagtgg agtagatgct aaagcgattc tttctgcacg     1020

attgagtaaa tcaagacgat tagaaaatct cattgctcag ctccccggtg agaagaaaaa     1080

tggcttattt gggaatctca ttgctttgtc attgggtttg acccctaatt ttaaatcaaa     1140

ttttgatttg gcagaagatg ctaaattaca gctttcaaaa gatacttacg atgatgattt     1200

agataattta ttggcgcaaa ttggagatca atatgctgat ttgtttttgg cagctaagaa     1260

tttatcagat gctattttac tttcagatat cctaagagta aatactgaaa taactaaggc     1320

tcccctatca gcttcaatga ttaaacgcta cgatgaacat catcaagact tgactctttt     1380

aaaagcttta gttcgacaac aacttccaga aaagtataaa gaaatctttt ttgatcaatc     1440

aaaaaacgga tatgcaggtt atattgatgg gggagctagc caagaagaat tttataaatt     1500

tatcaaacca attttagaaa aaatggatgg tactgaggaa ttattggtga aactaaatcg     1560

tgaagatttg ctgcgcaagc aacggacctt tgacaacggc tctattcccc atcaaattca     1620

cttgggtgag ctgcatgcta ttttgagaag acaagaagac ttttatccat ttttaaaaga     1680

caatcgtgag aagattgaaa aaatcttgac ttttcgaatt ccttattatg ttggtccatt     1740

ggcgcgtggc aatagtcgtt ttgcatggat gactcggaag tctgaagaaa caattacccc     1800

atggaatttt gaagaagttg tcgataaagg tgcttcagct caatcattta ttgaacgcat     1860

gacaaacttt gataaaaatc ttccaaatga aaaagtacta ccaaaacata gtttgcttta     1920

tgagtatttt acggtttata acgaattgac aaaggtcaaa tatgttactg aaggaatgcg     1980

aaaaccagca tttctttcag gtgaacagaa gaaagccatt gttgatttac tcttcaaaac     2040

aaatcgaaaa gtaaccgtta agcaattaaa agaagattat ttcaaaaaaa tagaatgttt     2100

tgatagtgtt gaaatttcag gagttgaaga tagatttaat gcttcattag gtacctacca     2160

tgatttgcta aaaattatta aagataaaga ttttttggat aatgaagaaa atgaagatat     2220

cttagaggat attgttttaa cattgacctt atttgaagat agggagatga ttgaggaaag     2280

acttaaaaca tatgctcacc tctttgatga taaggtgatg aaacagctta aacgtcgccg     2340

ttatactggt tggggacgtt tgtctcgaaa attgattaat ggtattaggg ataagcaatc     2400

tggcaaaaca atattagatt ttttgaaatc agatggtttt gccaatcgca attttatgca     2460

gctgatccat gatgatagtt tgacatttaa agaagacatt caaaaagcac aagtgtctgg     2520

acaaggcgat agtttacatg aacatattgc aaatttagct ggtagccctg ctattaaaaa     2580

aggtatttta cagactgtaa aagttgttga tgaattggtc aaagtaatgg ggcggcataa     2640

gccagaaaat atcgttattg aaatggcacg tgaaaatcag acaactcaaa agggccagaa     2700

aaattcgcga gagcgtatga aacgaatcga agaaggtatc aaagaattag gaagtcagat     2760

tcttaaagag catcctgttg aaaatactca attgcaaaat gaaaagctct atctctatta     2820

tctccaaaat ggaagagaca tgtatgtgga ccaagaatta gatattaatc gtttaagtga     2880

ttatgatgtc gatcacattg ttccacaaag tttccttaaa gacgattcaa tagacaataa     2940

ggtcttaacg cgttctgata aaaatcgtgg taaatcggat aacgttccaa gtgaagaagt     3000

agtcaaaaag atgaaaaact attggagaca acttctaaac gccaagttaa tcactcaacg     3060

taagtttgat aatttaacga aagctgaacg tggaggtttg agtgaacttg ataaagctgg     3120

ttttatcaaa cgccaattgg ttgaaactcg ccaaatcact aagcatgtgg cacaaatttt     3180

ggatagtcgc atgaatacta aatacgatga aaatgataaa cttattcgag aggttaaagt     3240

gattacctta aaatctaaat tagtttctga cttccgaaaa gatttccaat tctataaagt     3300

acgtgagatt aacaattacc atcatgccca tgatgcgtat ctaaatgccg tcgttggaac     3360

tgctttgatt aagaaatatc caaaacttga atcggagttt gtctatggtg attataaagt     3420

ttatgatgtt cgtaaaatga ttgctaagtc tgagcaagaa ataggcaaag caaccgcaaa     3480

atatttcttt tactctaata tcatgaactt cttcaaaaca gaaattacac ttgcaaatgg     3540

agagattcgc aaacgccctc taatcgaaac taatggggaa actggagaaa ttgtctggga     3600

taaagggcga gattttgcca cagtgcgcaa agtattgtcc atgccccaag tcaatattgt     3660

caagaaaaca gaagtacaga caggcggatt ctccaaggag tcaattttac caaaaagaaa     3720

ttcggacaag cttattgctc gtaaaaaaga ctgggatcca aaaaaatatg gtggttttga     3780

tagtccaacg gtagcttatt cagtcctagt ggttgctaag gtggaaaaag ggaaatcgaa     3840

gaagttaaaa tccgttaaag agttactagg gatcacaatt atggaaagaa gttcctttga     3900

aaaaaatccg attgactttt tagaagctaa aggatataag gaagttaaaa aagacttaat     3960

cattaaacta cctaaatata gtctttttga gttagaaaac ggtcgtaaac ggatgctggc     4020

tagtgccgga gaattacaaa aaggaaatga gctggctctg ccaagcaaat atgtgaattt     4080

tttatattta gctagtcatt atgaaaagtt gaagggtagt ccagaagata acgaacaaaa     4140

acaattgttt gtggagcagc ataagcatta tttagatgag attattgagc aaatcagtga     4200

attttctaag cgtgttattt tagcagatgc caatttagat aaagttctta gtgcatataa     4260

caaacataga gacaaaccaa tacgtgaaca agcagaaaat attattcatt tatttacgtt     4320

gacgaatctt ggagctcccg ctgcttttaa atattttgat acaacaattg atcgtaaacg     4380

atatacgtct acaaaagaag ttttagatgc cactcttatc catcaatcca tcactggtct     4440

ttatgaaaca cgcattgatt tgagtcagct aggaggtgac tgaccggctg ataaatttct     4500

ttgaatttct ccttgattat ttgttataaa tgttataaaa taatcttgtt ggaaccattc     4560

aaaacagcat agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg     4620

agtcggtgct ttttttgata cttctattct actctgactg caaaccaaaa aaacaagcgc     4680

tttcaaaacg cttgttttat catttttagg gaaattaatc tcttaatcct tttatcattc     4740

tacatttagg cgctgccatc ttgggacaat gaaaacgtta gtcatggcgc gccttgacgg     4800

ctagctcagt cctaggtaca gtgctagctt aattagtcta cgaggtttta gagctatgct     4860

gttttgaatg gtcccaaaac ctgcagacaa gcccggccgg cctaaggcga tgccccctcg     4920

acctcgatca gggaggcgtt caggacgact cacaaagaaa gccgggcaat gcccggcttt     4980

ttccacgcct cctgggctga cttcaggtgc tacatttgaa gagataaatt gcactgaaat     5040

ctagagcggt tcagtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     5100

aatcttttgc cctgtaaacg aaaaaaccac ctggggaggt ggtttgatcg aaggttaagt     5160

cagttgggga actgcttaac cgtggtaact ggctttcgca gagcacagca accaaatctg     5220

tccttccagt gtagccggac tttggcgcac acttcaagag caaccgcgtg tttagctaaa     5280

caaatcctct gcgaactccc agttaccaat ggctgctgcc agtggcgttt taccgtgctt     5340

ttccgggttg gactcaagtg aacagttacc ggataaggcg cagcagtcgg gctgaacggg     5400

gagttcttgc ttacagccca gcttggagcg aacgacctac accgagccga gataccagtg     5460

tgtgagctat gagaaagcgc cacacttccc gtaagggaga aaggcggaac aggtatccgg     5520

taaacggcag ggtcggaaca ggagagcgca agagggagcg acccgccgga aacggtgggg     5580

atctttaagt cctgtcgggt ttcgcccgta ctgtcagatt catggttgag cctcacggct     5640

cccacagatg caccggaaaa gcgtctgttt atgtgaactc tggcaggagg gcggagccta     5700

tggaaaaacg ccaccggcgc ggccctgctg ttttgcctca catgttagtc ccctgcttat     5760

ccacggaatc tgtgggtaac tttgtatgtg tccgcagcgc ccgccgcagt ctcacgcccg     5820

gagcgtagcg accgagtgag ctagctattt gtttattttt ctaaatacat tcaaatatgt     5880

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta     5940

tgagggaagc ggtgatcgcc gaagtatcga ctcaactatc agaggtagtt ggcgtcatcg     6000

agcgccatct cgaaccgacg ttgctggccg tacatttgta cggctccgca gtggatggcg     6060

gcctgaagcc acacagtgat attgatttgc tggttacggt gaccgtaagg cttgatgaaa     6120

caacgcggcg agctttgatc aacgaccttt tggaaacttc ggcttcccct ggagagagcg     6180

agattctccg cgctgtagaa gtcaccattg ttgtgcacga cgacatcatt ccgtggcgtt     6240

atccagctaa gcgcgaactg caatttggag aatggcagcg caatgacatt cttgcaggta     6300

tcttcgagcc agccacgatc gacattgatc tggctatctt gctgacaaaa gcaagagaac     6360

atagcgttgc cttggtaggt ccagcggcgg aggaactctt tgatccggtt cctgaacagg     6420

atctatttga ggcgctaaat gaaaccttaa cgctatggaa ctcgccgccc gactgggctg     6480

gcgatgagcg aaatgtagtg cttacgttgt cccgcatttg gtacagcgca gtaaccggca     6540

aaatcgcgcc gaaggatgtc gctgccgact gggcaatgga gcgcctgccg gcccagtatc     6600

agcccgtcat acttgaagct agacaggctt atcttggaca agaagaagat cgcttggcct     6660

cgcgcgcaga tcagttggaa gaatttgtcc actacgtgaa aggcgagatc accaaggtag     6720

tcggcaaata atgtctaaca attcgttcaa gccgaggggc cgcaagatcc ggccacgatg     6780

acccggtcgt cggttcaggg cagggt                                          6806


<210>  22
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Cre-Soc

<400>  22

Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe 
    50                  55                  60                  


Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala 
65                  70                  75                  80  


Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn 
                85                  90                  95      


Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala 
            100                 105                 110         


Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly 
        115                 120                 125             


Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln 
    130                 135                 140                 


Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn 
145                 150                 155                 160 


Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu 
                165                 170                 175     


Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg 
            180                 185                 190         


Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly 
        195                 200                 205             


Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp 
    210                 215                 220                 


Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys 
225                 230                 235                 240 


Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu 
                245                 250                 255     


Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile 
            260                 265                 270         


Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly 
        275                 280                 285             


His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val 
    290                 295                 300                 


Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile 
305                 310                 315                 320 


Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val 
                325                 330                 335     


Arg Leu Leu Glu Asp Gly Asp Gly Gly Ser Glu Phe Gly Gly Ser Gly 
            340                 345                 350         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Tyr Val Asn Ile Lys Thr 
        355                 360                 365             


Phe Thr His Pro Ala Gly Glu Gly Lys Glu Val Lys Gly Met Glu Val 
    370                 375                 380                 


Ser Val Pro Phe Glu Ile Tyr Ser Asn Glu His Arg Ile Ala Asp Ala 
385                 390                 395                 400 


His Tyr Gln Thr Phe Pro Ser Glu Lys Ala Ala Tyr Thr Thr Val Val 
                405                 410                 415     


Thr Asp Ala Ala Asp Trp Arg Thr Lys Asn Ala Ala Met Phe Thr Pro 
            420                 425                 430         


Thr Pro Val Ser Gly Gly Ser His His His His His His 
        435                 440                 445 


