                         SEQUENCE LISTING

<110>  Freeline Therapeutics Limited
 
<120>  POLYPEPTIDE

<130>  N417179WO

<150>  GB2011813.9
<151>  2020-07-29

<150>  GB2100648.1
<151>  2021-01-18

<150>  GB2105924.1
<151>  2021-04-26

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  2
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  3
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPRIV

<400>  3

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  4
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCase protein

<400>  4

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu Leu Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  5
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCase protein

<400>  5

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu Leu Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Asn Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  6
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
gccaggccct gcatccctaa gagctttggc tacagctctg tggtgtgtgt gtgcaatgcc       60

acctactgtg acagctttga cccccccacc tttcctgccc tgggcacctt cagcagatat      120

gagagcacca ggtctgggag gaggatggag ctgagcatgg ggcccatcca ggctaatcac      180

actggcactg gcctgctgct gaccctgcag cctgagcaga agttccagaa agtaaagggc      240

tttggagggg ccatgactga tgctgctgct ctgaacatcc tggccctgag cccccctgcc      300

cagaatctgc tgctgaagag ctacttctct gaggagggca ttggctataa catcatcagg      360

gtgcccatgg ccagctgtga cttcagcatc aggacctaca cctatgctga cacccctgat      420

gatttccagc tgcacaactt cagcctgcct gaggaggata ccaagctgaa gatcccactg      480

atccacaggg ctctgcagct ggcccagagg cctgtgagcc tgctggccag cccctggacc      540

agccccactt ggctgaagac caatggggct gtgaatggga aggggagcct gaagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agctgcagtt ctgggctgtg actgctcaga atgagccttc tgctgggctg      720

ctgtctggct accccttcca atgcctgggc ttcacccctg agcatcagag ggacttcatt      780

gccagggacc tgggccctac cctggccaac agcactcacc ataatgttag gctgctgatg      840

ctggatgacc agaggctgct gctgccccac tgggctaagg tggtgctgac tgaccctgag      900

gctgctaaat atgtgcatgg cattgctgtg cattggtacc tggactttct ggctcctgcc      960

aaggccaccc tgggggagac ccacaggctg ttccccaaca ccatgctgtt tgcctctgag     1020

gcctgtgtgg gcagcaagtt ctgggagcag tctgtgaggc tgggcagctg ggataggggg     1080

atgcagtaca gccacagcat catcaccaac ctgctgtacc atgtggtggg ctggactgac     1140

tggaacctgg ccctgaaccc tgagggagga cctaactggg tcagaaactt tgtggacagc     1200

cccatcattg tggacatcac caaggacacc ttttacaagc agcccatgtt ctaccacctg     1260

ggccacttca gcaagttcat ccctgagggc agccagagag tggggctggt ggccagccag     1320

aagaatgacc tggatgctgt ggctctgatg catcctgatg gctctgctgt ggtggtggtg     1380

ctgaacagga gctctaagga tgtgcctctg accatcaagg atcctgctgt gggcttcctg     1440

gagaccatca gccctggcta cagcatccac acctacctgt ggaggaggca gtga           1494


<210>  7
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
gccaggccct gtatccctaa gagctttggc tacagctcag tagtttgtgt ctgtaatgcc       60

acatactgtg actcctttga cccccctacc ttccctgccc tgggaacctt cagcagatat      120

gagtcaacaa gatcaggaag gaggatggag ctgtcaatgg gacccatcca ggctaatcac      180

acaggcacag gcctgctgct gaccctgcag ccagaacaga agttccagaa agtgaaggga      240

tttggaggag ccatgacaga tgctgctgct ctcaacatcc tggccctgtc accccctgcc      300

cagaatctgc tgctgaagtc atacttctct gaagaaggaa ttggatataa catcatcagg      360

gtgcccatgg ccagctgtga cttctccatc aggacctaca cctatgctga cacccctgat      420

gatttccagc tgcacaactt cagcctccca gaggaagata ccaagctcaa gatccctctg      480

atacataggg cactgcagct ggcccagagg cctgtgtcac tcctggccag cccctggaca      540

tcacccactt ggctcaagac caatggagct gtgaatggaa agggatcact caagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agctgcagtt ctgggcagtg acagctcaga atgagccttc tgctggactg      720

ctgtcaggat accccttcca gtgtctgggc ttcacccctg aacatcagag ggacttcatt      780

gccagggacc tgggacctac ccttgccaac tcaactcacc acaatgtcag gctgctcatg      840

ctggatgacc agaggctgct gctgccccac tgggccaagg tggtgctgac agacccagaa      900

gctgctaaat atgtgcatgg cattgctgtg cattggtacc tggacttcct ggctccagcc      960

aaggccaccc tgggagagac acacaggctg ttccccaaca ccatgctctt tgcctctgag     1020

gcctgtgtgg gctccaagtt ctgggagcag tcagtgaggc tgggctcctg ggatagggga     1080

atgcagtaca gccacagcat catcacaaac ctcctgtacc atgtggtggg ctggactgac     1140

tggaacctgg ccctgaaccc tgaaggagga cccaactggg tcagaaattt tgtggactca     1200

cccatcattg tggacatcac caaggacaca ttctacaagc agcccatgtt ctaccacctg     1260

ggccacttca gcaagttcat ccctgagggc tcccagaggg tgggactggt ggcctcacag     1320

aagaatgacc tggatgcagt ggccctgatg catcctgatg gctctgctgt ggtggttgtg     1380

ctgaatagat cctctaagga tgtgcctctg accatcaagg atcctgctgt gggcttcctg     1440

gagacaatct cacctggcta ctccatccac acctacctgt ggaggaggca gtga           1494


<210>  8
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
gccaggccct gcatccctaa gagctttggc tacagctctg tggtgtgtgt gtgcaatgcc       60

acatactgtg actcctttga cccccccacc tttcctgccc tgggcacatt ctccagatat      120

gagagcacaa gatctgggag aaggatggag ctgagcatgg ggcccatcca ggctaatcac      180

actggcacag gcctgctgct gaccctgcag cctgaacaga agtttcagaa agtgaaggga      240

tttggagggg ccatgacaga tgctgctgct ctgaatatcc tggccctgtc accccctgcc      300

cagaatctgc tgctgaagag ctacttttca gaagaaggaa ttggatataa tatcatcaga      360

gtgcccatgg ccagctgtga cttttccatc agaacctaca cctatgcaga cacccctgat      420

gattttcagc tgcacaattt tagcctgcct gaggaagata ccaagctgaa gatacccctg      480

attcacaggg ccctgcagct ggcccagagg cctgtttcac tgctggccag cccctggaca      540

tcacccacct ggctgaagac caatggagct gtgaatggga aggggtcact gaagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagtttct ggatgcctat      660

gctgagcaca agctgcagtt ttgggcagtg acagctcaga atgagccttc agctgggctg      720

ctgtcaggat acccctttca gtgcctgggc tttacccctg aacatcagag ggactttatt      780

gccagggacc tgggccctac cctggccaat agcacccacc ataatgtgag gttgctgatg      840

ctggatgacc agaggctgct gctgccccac tgggcaaagg tggtgctgac agaccctgaa      900

gcagctaaat atgttcatgg cattgctgtg cattggtacc tggactttct ggctcctgcc      960

aaggccaccc tgggggagac acacaggctg tttcccaata ccatgctgtt tgcctctgag     1020

gcctgtgtgg gctccaagtt ttgggagcag tctgtgaggc tgggctcctg ggatagaggg     1080

atgcagtaca gccacagcat catcaccaat ctgctgtacc atgtggtggg ctggactgac     1140

tggaatctgg ccctgaatcc tgaaggagga cctaactggg tcaggaattt tgtggacagc     1200

cccatcattg tggacatcac caaggacacc ttttacaagc agcccatgtt ttaccacctg     1260

ggccacttta gcaagtttat tcctgagggc tcccagagag tggggctggt tgccagccag     1320

aagaatgacc tggatgcagt ggcactgatg catcctgatg gctcagctgt tgtggtggtg     1380

ctgaatagat ccagcaagga tgtgcctctg accatcaagg atcctgctgt gggctttctg     1440

gagacaatct cacctggcta ctccattcac acctacctgt ggagaaggca gtga           1494


<210>  9
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
gccaggcctt gcatcccaaa gtctttcggc tacagctccg tggtgtgcgt gtgcaacgcc       60

acctattgtg actccttcga tccccctacc tttcccgccc tgggcacatt ttctagatac      120

gagtctacac gcagcggccg gagaatggag ctgagcatgg gccctatcca ggccaatcac      180

acaggaacag gcctgctgct gaccctgcag ccagagcaga agttccagaa ggtgaagggc      240

tttggcggag ccatgacaga tgcagccgcc ctgaacatcc tggccctgtc cccacccgcc      300

cagaatctgc tgctgaagtc ctacttctct gaggagggca tcggctataa catcatccgg      360

gtgcccatgg ccagctgcga cttttccatc agaacctaca catatgccga tacccctgac      420

gatttccagc tgcacaattt ttccctgcca gaggaggata caaagctgaa gatccccctg      480

attcaccggg ccctgcagct ggcacagcgg cccgtgagcc tgctggccag cccctggacc      540

tcccctacat ggctgaagac caacggcgcc gtgaatggca agggctctct gaagggacag      600

cctggcgaca tctaccacca gacatgggcc agatatttcg tgaagtttct ggatgcctac      660

gccgagcaca agctgcagtt ctgggccgtg acagcacaga atgagccttc tgccggcctg      720

ctgagcggct atcccttcca gtgcctgggc tttacacctg agcaccagcg ggactttatc      780

gccagagatc tgggcccaac cctggccaac tccacacacc acaatgtgag gctgctgatg      840

ctggacgatc agcgcctgct gctgcctcac tgggccaagg tggtgctgac cgacccagag      900

gccgccaagt acgtgcacgg catcgccgtg cactggtatc tggatttcct ggcacctgca      960

aaggccaccc tgggagagac acaccggctg ttccctaaca ccatgctgtt tgccagcgag     1020

gcctgcgtgg gctccaagtt ttgggagcag tccgtgaggc tgggatcttg ggacagaggc     1080

atgcagtact cccactctat catcaccaat ctgctgtatc acgtggtggg ctggacagac     1140

tggaacctgg ccctgaatcc agagggcggc cccaactggg tgagaaattt cgtggatagc     1200

cccatcatcg tggacatcac caaggataca ttctacaagc agccaatgtt ttatcacctg     1260

ggccacttct ctaagtttat ccctgagggc agccagaggg tgggcctggt ggccagccag     1320

aagaacgacc tggatgccgt ggccctgatg caccctgatg gctccgccgt ggtggtggtg     1380

ctgaatcgct ctagcaagga cgtgcctctg accatcaagg atccagccgt gggatttctg     1440

gagactattt cacctggcta ttcaattcat acctacctgt ggaggaggca gtga           1494


<210>  10
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctcagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  11
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgta tccctaagag ctttggctac agctcagtag tttgtgtctg taatgccaca      180

tactgtgact cctttgaccc ccctaccttc cctgccctgg gaaccttcag cagatatgag      240

tcaacaagat caggaaggag gatggagctg tcaatgggac ccatccaggc taatcacaca      300

ggcacaggcc tgctgctgac cctgcagcca gaacagaagt tccagaaagt gaagggattt      360

ggaggagcca tgacagatgc tgctgctctc aacatcctgg ccctgtcacc ccctgcccag      420

aatctgctgc tgaagtcata cttctctgaa gaaggaattg gatataacat catcagggtg      480

cccatggcca gctgtgactt ctccatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctcccagag gaagatacca agctcaagat ccctctgata      600

catagggcac tgcagctggc ccagaggcct gtgtcactcc tggccagccc ctggacatca      660

cccacttggc tcaagaccaa tggagctgtg aatggaaagg gatcactcaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggcagtgaca gctcagaatg agccttctgc tggactgctg      840

tcaggatacc ccttccagtg tctgggcttc acccctgaac atcagaggga cttcattgcc      900

agggacctgg gacctaccct tgccaactca actcaccaca atgtcaggct gctcatgctg      960

gatgaccaga ggctgctgct gccccactgg gccaaggtgg tgctgacaga cccagaagct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg acttcctggc tccagccaag     1080

gccaccctgg gagagacaca caggctgttc cccaacacca tgctctttgc ctctgaggcc     1140

tgtgtgggct ccaagttctg ggagcagtca gtgaggctgg gctcctggga taggggaatg     1200

cagtacagcc acagcatcat cacaaacctc ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga aggaggaccc aactgggtca gaaattttgt ggactcaccc     1320

atcattgtgg acatcaccaa ggacacattc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggctcc cagagggtgg gactggtggc ctcacagaag     1440

aatgacctgg atgcagtggc cctgatgcat cctgatggct ctgctgtggt ggttgtgctg     1500

aatagatcct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

acaatctcac ctggctactc catccacacc tacctgtgga ggaggcagtg a              1611


<210>  12
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccaca      180

tactgtgact cctttgaccc ccccaccttt cctgccctgg gcacattctc cagatatgag      240

agcacaagat ctgggagaag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcacaggcc tgctgctgac cctgcagcct gaacagaagt ttcagaaagt gaagggattt      360

ggaggggcca tgacagatgc tgctgctctg aatatcctgg ccctgtcacc ccctgcccag      420

aatctgctgc tgaagagcta cttttcagaa gaaggaattg gatataatat catcagagtg      480

cccatggcca gctgtgactt ttccatcaga acctacacct atgcagacac ccctgatgat      540

tttcagctgc acaattttag cctgcctgag gaagatacca agctgaagat acccctgatt      600

cacagggccc tgcagctggc ccagaggcct gtttcactgc tggccagccc ctggacatca      660

cccacctggc tgaagaccaa tggagctgtg aatgggaagg ggtcactgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agtttctgga tgcctatgct      780

gagcacaagc tgcagttttg ggcagtgaca gctcagaatg agccttcagc tgggctgctg      840

tcaggatacc cctttcagtg cctgggcttt acccctgaac atcagaggga ctttattgcc      900

agggacctgg gccctaccct ggccaatagc acccaccata atgtgaggtt gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gcaaaggtgg tgctgacaga ccctgaagca     1020

gctaaatatg ttcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagacaca caggctgttt cccaatacca tgctgtttgc ctctgaggcc     1140

tgtgtgggct ccaagttttg ggagcagtct gtgaggctgg gctcctggga tagagggatg     1200

cagtacagcc acagcatcat caccaatctg ctgtaccatg tggtgggctg gactgactgg     1260

aatctggccc tgaatcctga aggaggacct aactgggtca ggaattttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgtttta ccacctgggc     1380

cactttagca agtttattcc tgagggctcc cagagagtgg ggctggttgc cagccagaag     1440

aatgacctgg atgcagtggc actgatgcat cctgatggct cagctgttgt ggtggtgctg     1500

aatagatcca gcaaggatgt gcctctgacc atcaaggatc ctgctgtggg ctttctggag     1560

acaatctcac ctggctactc cattcacacc tacctgtgga gaaggcagtg a              1611


<210>  13
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccttgca tcccaaagtc tttcggctac agctccgtgg tgtgcgtgtg caacgccacc      180

tattgtgact ccttcgatcc ccctaccttt cccgccctgg gcacattttc tagatacgag      240

tctacacgca gcggccggag aatggagctg agcatgggcc ctatccaggc caatcacaca      300

ggaacaggcc tgctgctgac cctgcagcca gagcagaagt tccagaaggt gaagggcttt      360

ggcggagcca tgacagatgc agccgccctg aacatcctgg ccctgtcccc acccgcccag      420

aatctgctgc tgaagtccta cttctctgag gagggcatcg gctataacat catccgggtg      480

cccatggcca gctgcgactt ttccatcaga acctacacat atgccgatac ccctgacgat      540

ttccagctgc acaatttttc cctgccagag gaggatacaa agctgaagat ccccctgatt      600

caccgggccc tgcagctggc acagcggccc gtgagcctgc tggccagccc ctggacctcc      660

cctacatggc tgaagaccaa cggcgccgtg aatggcaagg gctctctgaa gggacagcct      720

ggcgacatct accaccagac atgggccaga tatttcgtga agtttctgga tgcctacgcc      780

gagcacaagc tgcagttctg ggccgtgaca gcacagaatg agccttctgc cggcctgctg      840

agcggctatc ccttccagtg cctgggcttt acacctgagc accagcggga ctttatcgcc      900

agagatctgg gcccaaccct ggccaactcc acacaccaca atgtgaggct gctgatgctg      960

gacgatcagc gcctgctgct gcctcactgg gccaaggtgg tgctgaccga cccagaggcc     1020

gccaagtacg tgcacggcat cgccgtgcac tggtatctgg atttcctggc acctgcaaag     1080

gccaccctgg gagagacaca ccggctgttc cctaacacca tgctgtttgc cagcgaggcc     1140

tgcgtgggct ccaagttttg ggagcagtcc gtgaggctgg gatcttggga cagaggcatg     1200

cagtactccc actctatcat caccaatctg ctgtatcacg tggtgggctg gacagactgg     1260

aacctggccc tgaatccaga gggcggcccc aactgggtga gaaatttcgt ggatagcccc     1320

atcatcgtgg acatcaccaa ggatacattc tacaagcagc caatgtttta tcacctgggc     1380

cacttctcta agtttatccc tgagggcagc cagagggtgg gcctggtggc cagccagaag     1440

aacgacctgg atgccgtggc cctgatgcac cctgatggct ccgccgtggt ggtggtgctg     1500

aatcgctcta gcaaggacgt gcctctgacc atcaaggatc cagccgtggg atttctggag     1560

actatttcac ctggctattc aattcatacc tacctgtgga ggaggcagtg a              1611


<210>  14
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
gccaggccct gcatccctaa gagctttggc tacagctctg tggtgtgtgt gtgcaatgcc       60

acctactgtg acagctttga cccccccacc tttcctgccc tgggcacctt cagcagatat      120

gagagcacca ggtctgggag gaggatggag ctgagcatgg ggcccatcca ggctaatcac      180

actggcactg gcctgctgct gaccctgcag cctgagcaga agttccagaa agtaaagggc      240

tttggagggg ccatgactga tgctgctgct ctgaacatcc tggccctgag cccccctgcc      300

cagaatctgc tgctgaagag ctacttctct gaggagggca ttggctataa catcatcagg      360

gtgcccatgg ccagctgtga cttcagcatc aggacctaca cctatgctga cacccctgat      420

gatttccagc tgcacaactt cagcctgcct gaggaggata ccaagctgaa gatcccactg      480

atccacaggg ctctgcagct ggcccagagg cctgtgagcc tgctggccag cccctggacc      540

agccccactt ggctgaagac caatggggct gtgaatggga aggggagcct gaagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agctgcagtt ctgggctgtg actgctgaga atgagccttc tgctgggctg      720

ctgtctggct accccttcca atgcctgggc ttcacccctg agcatcagag ggacttcatt      780

gccagggacc tgggccctac cctggccaac agcactcacc ataatgttag gctgctgatg      840

ctggatgacc agaggctgct gctgccccac tgggctaagg tggtgctgac tgaccctgag      900

gctgctaaat atgtgcatgg cattgctgtg cattgctacc tggactttct ggctcctgcc      960

aaggccaccc tgggggagac ccacaggctg ttccccaaca ccatgctgtt tgcctctgag     1020

tgctgtgtgg gcagcaagtt ctgggagcag tctgtgaggc tgggcagctg ggataggggg     1080

atgcagtaca gccacagcat catcaccaac ctgctgtacc atgtggtggg ctggactgac     1140

tggaacctgg ccctgaaccc tgagggagga cctaactggg tcagaaactt tgtggacagc     1200

cccatcattg tggacatcac caaggacacc ttttacaagc agcccatgtt ctaccacctg     1260

ggccacttca gcaagttcat ccctgagggc agccagagag tggggctggt ggccagccag     1320

aagaatgacc tggatgctgt ggctctgatg catcctgatg gctctgctgt ggtggtggtg     1380

ctgaacagga gctctaagga tgtgcctctg accatcaagg atcctgctgt gggcttcctg     1440

gagaccatca gccctggcta cagcatccac acctacctgt ggaggaggca gtga           1494


<210>  15
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
gccaggccct gtatccctaa gagctttggc tacagctcag tagtttgtgt ctgtaatgcc       60

acatactgtg actcctttga cccccctacc ttccctgccc tgggaacctt cagcagatat      120

gagtcaacaa gatcaggaag gaggatggag ctgtcaatgg gacccatcca ggctaatcac      180

acaggcacag gcctgctgct gaccctgcag ccagaacaga agttccagaa agtgaaggga      240

tttggaggag ccatgacaga tgctgctgct ctcaacatcc tggccctgtc accccctgcc      300

cagaatctgc tgctgaagtc atacttctct gaagaaggaa ttggatataa catcatcagg      360

gtgcccatgg ccagctgtga cttctccatc aggacctaca cctatgctga cacccctgat      420

gatttccagc tgcacaactt cagcctccca gaggaagata ccaagctcaa gatccctctg      480

atacataggg cactgcagct ggcccagagg cctgtgtcac tcctggccag cccctggaca      540

tcacccactt ggctcaagac caatggagct gtgaatggaa agggatcact caagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agctgcagtt ctgggcagtg acagctgaaa atgagccttc tgctggactg      720

ctgtcaggat accccttcca gtgtctgggc ttcacccctg aacatcagag ggacttcatt      780

gccagggacc tgggacctac ccttgccaac tcaactcacc acaatgtcag gctgctcatg      840

ctggatgacc agaggctgct gctgccccac tgggccaagg tggtgctgac agacccagaa      900

gctgctaaat atgtgcatgg cattgctgtg cattgctacc tggacttcct ggctccagcc      960

aaggccaccc tgggagagac acacaggctg ttccccaaca ccatgctctt tgcctctgag     1020

tgctgtgtgg gctccaagtt ctgggagcag tcagtgaggc tgggctcctg ggatagggga     1080

atgcagtaca gccacagcat catcacaaac ctcctgtacc atgtggtggg ctggactgac     1140

tggaacctgg ccctgaaccc tgaaggagga cccaactggg tcagaaattt tgtggactca     1200

cccatcattg tggacatcac caaggacaca ttctacaagc agcccatgtt ctaccacctg     1260

ggccacttca gcaagttcat ccctgagggc tcccagaggg tgggactggt ggcctcacag     1320

aagaatgacc tggatgcagt ggccctgatg catcctgatg gctctgctgt ggtggttgtg     1380

ctgaatagat cctctaagga tgtgcctctg accatcaagg atcctgctgt gggcttcctg     1440

gagacaatct cacctggcta ctccatccac acctacctgt ggaggaggca gtga           1494


<210>  16
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
gccaggccct gcatccctaa gagctttggc tacagctctg tggtgtgtgt gtgcaatgcc       60

acatactgtg actcctttga cccccccacc tttcctgccc tgggcacatt ctccagatat      120

gagagcacaa gatctgggag aaggatggag ctgagcatgg ggcccatcca ggctaatcac      180

actggcacag gcctgctgct gaccctgcag cctgaacaga agtttcagaa agtgaaggga      240

tttggagggg ccatgacaga tgctgctgct ctgaatatcc tggccctgtc accccctgcc      300

cagaatctgc tgctgaagag ctacttttca gaagaaggaa ttggatataa tatcatcaga      360

gtgcccatgg ccagctgtga cttttccatc agaacctaca cctatgcaga cacccctgat      420

gattttcagc tgcacaattt tagcctgcct gaggaagata ccaagctgaa gatacccctg      480

attcacaggg ccctgcagct ggcccagagg cctgtttcac tgctggccag cccctggaca      540

tcacccacct ggctgaagac caatggagct gtgaatggga aggggtcact gaagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagtttct ggatgcctat      660

gctgagcaca agctgcagtt ttgggcagtg acagctgaaa atgagccttc agctgggctg      720

ctgtcaggat acccctttca gtgcctgggc tttacccctg aacatcagag ggactttatt      780

gccagggacc tgggccctac cctggccaat agcacccacc ataatgtgag gttgctgatg      840

ctggatgacc agaggctgct gctgccccac tgggcaaagg tggtgctgac agaccctgaa      900

gcagctaaat atgttcatgg cattgctgtg cattgctacc tggactttct ggctcctgcc      960

aaggccaccc tgggggagac acacaggctg tttcccaata ccatgctgtt tgcctctgag     1020

tgctgtgtgg gctccaagtt ttgggagcag tctgtgaggc tgggctcctg ggatagaggg     1080

atgcagtaca gccacagcat catcaccaat ctgctgtacc atgtggtggg ctggactgac     1140

tggaatctgg ccctgaatcc tgaaggagga cctaactggg tcaggaattt tgtggacagc     1200

cccatcattg tggacatcac caaggacacc ttttacaagc agcccatgtt ttaccacctg     1260

ggccacttta gcaagtttat tcctgagggc tcccagagag tggggctggt tgccagccag     1320

aagaatgacc tggatgcagt ggcactgatg catcctgatg gctcagctgt tgtggtggtg     1380

ctgaatagat ccagcaagga tgtgcctctg accatcaagg atcctgctgt gggctttctg     1440

gagacaatct cacctggcta ctccattcac acctacctgt ggagaaggca gtga           1494


<210>  17
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
gccaggcctt gcatcccaaa gtctttcggc tacagctccg tggtgtgcgt gtgcaacgcc       60

acctattgtg actccttcga tccccctacc tttcccgccc tgggcacatt ttctagatac      120

gagtctacac gcagcggccg gagaatggag ctgagcatgg gccctatcca ggccaatcac      180

acaggaacag gcctgctgct gaccctgcag ccagagcaga agttccagaa ggtgaagggc      240

tttggcggag ccatgacaga tgcagccgcc ctgaacatcc tggccctgtc cccacccgcc      300

cagaatctgc tgctgaagtc ctacttctct gaggagggca tcggctataa catcatccgg      360

gtgcccatgg ccagctgcga cttttccatc agaacctaca catatgccga tacccctgac      420

gatttccagc tgcacaattt ttccctgcca gaggaggata caaagctgaa gatccccctg      480

attcaccggg ccctgcagct ggcacagcgg cccgtgagcc tgctggccag cccctggacc      540

tcccctacat ggctgaagac caacggcgcc gtgaatggca agggctctct gaagggacag      600

cctggcgaca tctaccacca gacatgggcc agatatttcg tgaagtttct ggatgcctac      660

gccgagcaca agctgcagtt ctgggccgtg acagcagaga atgagccttc tgccggcctg      720

ctgagcggct atcccttcca gtgcctgggc tttacacctg agcaccagcg ggactttatc      780

gccagagatc tgggcccaac cctggccaac tccacacacc acaatgtgag gctgctgatg      840

ctggacgatc agcgcctgct gctgcctcac tgggccaagg tggtgctgac cgacccagag      900

gccgccaagt acgtgcacgg catcgccgtg cactgctatc tggatttcct ggcacctgca      960

aaggccaccc tgggagagac acaccggctg ttccctaaca ccatgctgtt tgccagcgag     1020

tgctgcgtgg gctccaagtt ttgggagcag tccgtgaggc tgggatcttg ggacagaggc     1080

atgcagtact cccactctat catcaccaat ctgctgtatc acgtggtggg ctggacagac     1140

tggaacctgg ccctgaatcc agagggcggc cccaactggg tgagaaattt cgtggatagc     1200

cccatcatcg tggacatcac caaggataca ttctacaagc agccaatgtt ttatcacctg     1260

ggccacttct ctaagtttat ccctgagggc agccagaggg tgggcctggt ggccagccag     1320

aagaacgacc tggatgccgt ggccctgatg caccctgatg gctccgccgt ggtggtggtg     1380

ctgaatcgct ctagcaagga cgtgcctctg accatcaagg atccagccgt gggatttctg     1440

gagactattt cacctggcta ttcaattcat acctacctgt ggaggaggca gtga           1494


<210>  18
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tgctacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgagtgc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  19
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgta tccctaagag ctttggctac agctcagtag tttgtgtctg taatgccaca      180

tactgtgact cctttgaccc ccctaccttc cctgccctgg gaaccttcag cagatatgag      240

tcaacaagat caggaaggag gatggagctg tcaatgggac ccatccaggc taatcacaca      300

ggcacaggcc tgctgctgac cctgcagcca gaacagaagt tccagaaagt gaagggattt      360

ggaggagcca tgacagatgc tgctgctctc aacatcctgg ccctgtcacc ccctgcccag      420

aatctgctgc tgaagtcata cttctctgaa gaaggaattg gatataacat catcagggtg      480

cccatggcca gctgtgactt ctccatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctcccagag gaagatacca agctcaagat ccctctgata      600

catagggcac tgcagctggc ccagaggcct gtgtcactcc tggccagccc ctggacatca      660

cccacttggc tcaagaccaa tggagctgtg aatggaaagg gatcactcaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggcagtgaca gctgaaaatg agccttctgc tggactgctg      840

tcaggatacc ccttccagtg tctgggcttc acccctgaac atcagaggga cttcattgcc      900

agggacctgg gacctaccct tgccaactca actcaccaca atgtcaggct gctcatgctg      960

gatgaccaga ggctgctgct gccccactgg gccaaggtgg tgctgacaga cccagaagct     1020

gctaaatatg tgcatggcat tgctgtgcat tgctacctgg acttcctggc tccagccaag     1080

gccaccctgg gagagacaca caggctgttc cccaacacca tgctctttgc ctctgagtgc     1140

tgtgtgggct ccaagttctg ggagcagtca gtgaggctgg gctcctggga taggggaatg     1200

cagtacagcc acagcatcat cacaaacctc ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga aggaggaccc aactgggtca gaaattttgt ggactcaccc     1320

atcattgtgg acatcaccaa ggacacattc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggctcc cagagggtgg gactggtggc ctcacagaag     1440

aatgacctgg atgcagtggc cctgatgcat cctgatggct ctgctgtggt ggttgtgctg     1500

aatagatcct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

acaatctcac ctggctactc catccacacc tacctgtgga ggaggcagtg a              1611


<210>  20
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccaca      180

tactgtgact cctttgaccc ccccaccttt cctgccctgg gcacattctc cagatatgag      240

agcacaagat ctgggagaag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcacaggcc tgctgctgac cctgcagcct gaacagaagt ttcagaaagt gaagggattt      360

ggaggggcca tgacagatgc tgctgctctg aatatcctgg ccctgtcacc ccctgcccag      420

aatctgctgc tgaagagcta cttttcagaa gaaggaattg gatataatat catcagagtg      480

cccatggcca gctgtgactt ttccatcaga acctacacct atgcagacac ccctgatgat      540

tttcagctgc acaattttag cctgcctgag gaagatacca agctgaagat acccctgatt      600

cacagggccc tgcagctggc ccagaggcct gtttcactgc tggccagccc ctggacatca      660

cccacctggc tgaagaccaa tggagctgtg aatgggaagg ggtcactgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agtttctgga tgcctatgct      780

gagcacaagc tgcagttttg ggcagtgaca gctgaaaatg agccttcagc tgggctgctg      840

tcaggatacc cctttcagtg cctgggcttt acccctgaac atcagaggga ctttattgcc      900

agggacctgg gccctaccct ggccaatagc acccaccata atgtgaggtt gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gcaaaggtgg tgctgacaga ccctgaagca     1020

gctaaatatg ttcatggcat tgctgtgcat tgctacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagacaca caggctgttt cccaatacca tgctgtttgc ctctgagtgc     1140

tgtgtgggct ccaagttttg ggagcagtct gtgaggctgg gctcctggga tagagggatg     1200

cagtacagcc acagcatcat caccaatctg ctgtaccatg tggtgggctg gactgactgg     1260

aatctggccc tgaatcctga aggaggacct aactgggtca ggaattttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgtttta ccacctgggc     1380

cactttagca agtttattcc tgagggctcc cagagagtgg ggctggttgc cagccagaag     1440

aatgacctgg atgcagtggc actgatgcat cctgatggct cagctgttgt ggtggtgctg     1500

aatagatcca gcaaggatgt gcctctgacc atcaaggatc ctgctgtggg ctttctggag     1560

acaatctcac ctggctactc cattcacacc tacctgtgga gaaggcagtg a              1611


<210>  21
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccttgca tcccaaagtc tttcggctac agctccgtgg tgtgcgtgtg caacgccacc      180

tattgtgact ccttcgatcc ccctaccttt cccgccctgg gcacattttc tagatacgag      240

tctacacgca gcggccggag aatggagctg agcatgggcc ctatccaggc caatcacaca      300

ggaacaggcc tgctgctgac cctgcagcca gagcagaagt tccagaaggt gaagggcttt      360

ggcggagcca tgacagatgc agccgccctg aacatcctgg ccctgtcccc acccgcccag      420

aatctgctgc tgaagtccta cttctctgag gagggcatcg gctataacat catccgggtg      480

cccatggcca gctgcgactt ttccatcaga acctacacat atgccgatac ccctgacgat      540

ttccagctgc acaatttttc cctgccagag gaggatacaa agctgaagat ccccctgatt      600

caccgggccc tgcagctggc acagcggccc gtgagcctgc tggccagccc ctggacctcc      660

cctacatggc tgaagaccaa cggcgccgtg aatggcaagg gctctctgaa gggacagcct      720

ggcgacatct accaccagac atgggccaga tatttcgtga agtttctgga tgcctacgcc      780

gagcacaagc tgcagttctg ggccgtgaca gcagagaatg agccttctgc cggcctgctg      840

agcggctatc ccttccagtg cctgggcttt acacctgagc accagcggga ctttatcgcc      900

agagatctgg gcccaaccct ggccaactcc acacaccaca atgtgaggct gctgatgctg      960

gacgatcagc gcctgctgct gcctcactgg gccaaggtgg tgctgaccga cccagaggcc     1020

gccaagtacg tgcacggcat cgccgtgcac tgctatctgg atttcctggc acctgcaaag     1080

gccaccctgg gagagacaca ccggctgttc cctaacacca tgctgtttgc cagcgagtgc     1140

tgcgtgggct ccaagttttg ggagcagtcc gtgaggctgg gatcttggga cagaggcatg     1200

cagtactccc actctatcat caccaatctg ctgtatcacg tggtgggctg gacagactgg     1260

aacctggccc tgaatccaga gggcggcccc aactgggtga gaaatttcgt ggatagcccc     1320

atcatcgtgg acatcaccaa ggatacattc tacaagcagc caatgtttta tcacctgggc     1380

cacttctcta agtttatccc tgagggcagc cagagggtgg gcctggtggc cagccagaag     1440

aacgacctgg atgccgtggc cctgatgcac cctgatggct ccgccgtggt ggtggtgctg     1500

aatcgctcta gcaaggacgt gcctctgacc atcaaggatc cagccgtggg atttctggag     1560

actatttcac ctggctattc aattcatacc tacctgtgga ggaggcagtg a              1611


<210>  22
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
gccaggccct gcatccctaa gagctttggc tacagctctg tggtgtgtgt gtgcaatgcc       60

acctactgtg acagctttga cccccccacc tttcctgccc tgggcacctt cagcagatat      120

gagagcacca ggtctgggag gaggatggag ctgagcatgg ggcccatcca ggctaatcac      180

actggcactg gcctgctgct gaccctgcag cctgagcaga agttccagaa agtaaagggc      240

tttggagggg ccatgactga tgctgctgct ctgaacatcc tggccctgag cccccctgcc      300

cagaatctgc tgctgaagag ctacttctct gaggagggca ttggctataa catcatcagg      360

gtgcccatgg ccagctgtga cttcagcatc aggacctaca cctatgctga cacccctgat      420

gatttccagc tgcacaactt cagcctgcct gaggaggata ccaagctgaa gatcccactg      480

atccacaggg ctctgcagct ggcccagagg cctgtgagcc tgctggccag cccctggacc      540

agccccactt ggctgaagac caatggggct gtgaatggga aggggagcct gaagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agctgcagtt ctgggctgtg actgctcaga atgagccttc tgctgggctg      720

ctgtctggct accccttcca atgcctgggc ttcacccctg agcatcagag ggacttcatt      780

gccagggacc tgggccctac cctggccaac agcactcacc ataatgttag gctgctgatg      840

ctggatgacc agaggctgct gctgccccac tgggctaagg tggtgctgac tgaccctgag      900

gctgctaaat atgtgcatgg cattgctgtg cattgctacc tggactttct ggctcctgcc      960

aaggccaccc tgggggagac ccacaggctg ttccccaaca ccatgctgtt tgcctctgag     1020

tgctgtgtgg gcagcaagtt ctgggagcag tctgtgaggc tgggcagctg ggataggggg     1080

atgcagtaca gccacagcat catcaccaac ctgctgtacc atgtggtggg ctggactgac     1140

tggaacctgg ccctgaaccc tgagggagga cctaactggg tcagaaactt tgtggacagc     1200

cccatcattg tggacatcac caaggacacc ttttacaagc agcccatgtt ctaccacctg     1260

ggccacttca gcaagttcat ccctgagggc agccagagag tggggctggt ggccagccag     1320

aagaatgacc tggatgctgt ggctctgatg catcctgatg gctctgctgt ggtggtggtg     1380

ctgaacagga gctctaagga tgtgcctctg accatcaagg atcctgctgt gggcttcctg     1440

gagaccatca gccctggcta cagcatccac acctacctgt ggaggaggca gtga           1494


<210>  23
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23
gccaggccct gtatccctaa gagctttggc tacagctcag tagtttgtgt ctgtaatgcc       60

acatactgtg actcctttga cccccctacc ttccctgccc tgggaacctt cagcagatat      120

gagtcaacaa gatcaggaag gaggatggag ctgtcaatgg gacccatcca ggctaatcac      180

acaggcacag gcctgctgct gaccctgcag ccagaacaga agttccagaa agtgaaggga      240

tttggaggag ccatgacaga tgctgctgct ctcaacatcc tggccctgtc accccctgcc      300

cagaatctgc tgctgaagtc atacttctct gaagaaggaa ttggatataa catcatcagg      360

gtgcccatgg ccagctgtga cttctccatc aggacctaca cctatgctga cacccctgat      420

gatttccagc tgcacaactt cagcctccca gaggaagata ccaagctcaa gatccctctg      480

atacataggg cactgcagct ggcccagagg cctgtgtcac tcctggccag cccctggaca      540

tcacccactt ggctcaagac caatggagct gtgaatggaa agggatcact caagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agctgcagtt ctgggcagtg acagctcaga atgagccttc tgctggactg      720

ctgtcaggat accccttcca gtgtctgggc ttcacccctg aacatcagag ggacttcatt      780

gccagggacc tgggacctac ccttgccaac tcaactcacc acaatgtcag gctgctcatg      840

ctggatgacc agaggctgct gctgccccac tgggccaagg tggtgctgac agacccagaa      900

gctgctaaat atgtgcatgg cattgctgtg cattgctacc tggacttcct ggctccagcc      960

aaggccaccc tgggagagac acacaggctg ttccccaaca ccatgctctt tgcctctgag     1020

tgctgtgtgg gctccaagtt ctgggagcag tcagtgaggc tgggctcctg ggatagggga     1080

atgcagtaca gccacagcat catcacaaac ctcctgtacc atgtggtggg ctggactgac     1140

tggaacctgg ccctgaaccc tgaaggagga cccaactggg tcagaaattt tgtggactca     1200

cccatcattg tggacatcac caaggacaca ttctacaagc agcccatgtt ctaccacctg     1260

ggccacttca gcaagttcat ccctgagggc tcccagaggg tgggactggt ggcctcacag     1320

aagaatgacc tggatgcagt ggccctgatg catcctgatg gctctgctgt ggtggttgtg     1380

ctgaatagat cctctaagga tgtgcctctg accatcaagg atcctgctgt gggcttcctg     1440

gagacaatct cacctggcta ctccatccac acctacctgt ggaggaggca gtga           1494


<210>  24
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24
gccaggccct gcatccctaa gagctttggc tacagctctg tggtgtgtgt gtgcaatgcc       60

acatactgtg actcctttga cccccccacc tttcctgccc tgggcacatt ctccagatat      120

gagagcacaa gatctgggag aaggatggag ctgagcatgg ggcccatcca ggctaatcac      180

actggcacag gcctgctgct gaccctgcag cctgaacaga agtttcagaa agtgaaggga      240

tttggagggg ccatgacaga tgctgctgct ctgaatatcc tggccctgtc accccctgcc      300

cagaatctgc tgctgaagag ctacttttca gaagaaggaa ttggatataa tatcatcaga      360

gtgcccatgg ccagctgtga cttttccatc agaacctaca cctatgcaga cacccctgat      420

gattttcagc tgcacaattt tagcctgcct gaggaagata ccaagctgaa gatacccctg      480

attcacaggg ccctgcagct ggcccagagg cctgtttcac tgctggccag cccctggaca      540

tcacccacct ggctgaagac caatggagct gtgaatggga aggggtcact gaagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagtttct ggatgcctat      660

gctgagcaca agctgcagtt ttgggcagtg acagctcaga atgagccttc agctgggctg      720

ctgtcaggat acccctttca gtgcctgggc tttacccctg aacatcagag ggactttatt      780

gccagggacc tgggccctac cctggccaat agcacccacc ataatgtgag gttgctgatg      840

ctggatgacc agaggctgct gctgccccac tgggcaaagg tggtgctgac agaccctgaa      900

gcagctaaat atgttcatgg cattgctgtg cattgctacc tggactttct ggctcctgcc      960

aaggccaccc tgggggagac acacaggctg tttcccaata ccatgctgtt tgcctctgag     1020

tgctgtgtgg gctccaagtt ttgggagcag tctgtgaggc tgggctcctg ggatagaggg     1080

atgcagtaca gccacagcat catcaccaat ctgctgtacc atgtggtggg ctggactgac     1140

tggaatctgg ccctgaatcc tgaaggagga cctaactggg tcaggaattt tgtggacagc     1200

cccatcattg tggacatcac caaggacacc ttttacaagc agcccatgtt ttaccacctg     1260

ggccacttta gcaagtttat tcctgagggc tcccagagag tggggctggt tgccagccag     1320

aagaatgacc tggatgcagt ggcactgatg catcctgatg gctcagctgt tgtggtggtg     1380

ctgaatagat ccagcaagga tgtgcctctg accatcaagg atcctgctgt gggctttctg     1440

gagacaatct cacctggcta ctccattcac acctacctgt ggagaaggca gtga           1494


<210>  25
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
gccaggcctt gcatcccaaa gtctttcggc tacagctccg tggtgtgcgt gtgcaacgcc       60

acctattgtg actccttcga tccccctacc tttcccgccc tgggcacatt ttctagatac      120

gagtctacac gcagcggccg gagaatggag ctgagcatgg gccctatcca ggccaatcac      180

acaggaacag gcctgctgct gaccctgcag ccagagcaga agttccagaa ggtgaagggc      240

tttggcggag ccatgacaga tgcagccgcc ctgaacatcc tggccctgtc cccacccgcc      300

cagaatctgc tgctgaagtc ctacttctct gaggagggca tcggctataa catcatccgg      360

gtgcccatgg ccagctgcga cttttccatc agaacctaca catatgccga tacccctgac      420

gatttccagc tgcacaattt ttccctgcca gaggaggata caaagctgaa gatccccctg      480

attcaccggg ccctgcagct ggcacagcgg cccgtgagcc tgctggccag cccctggacc      540

tcccctacat ggctgaagac caacggcgcc gtgaatggca agggctctct gaagggacag      600

cctggcgaca tctaccacca gacatgggcc agatatttcg tgaagtttct ggatgcctac      660

gccgagcaca agctgcagtt ctgggccgtg acagcacaga atgagccttc tgccggcctg      720

ctgagcggct atcccttcca gtgcctgggc tttacacctg agcaccagcg ggactttatc      780

gccagagatc tgggcccaac cctggccaac tccacacacc acaatgtgag gctgctgatg      840

ctggacgatc agcgcctgct gctgcctcac tgggccaagg tggtgctgac cgacccagag      900

gccgccaagt acgtgcacgg catcgccgtg cactgctatc tggatttcct ggcacctgca      960

aaggccaccc tgggagagac acaccggctg ttccctaaca ccatgctgtt tgccagcgag     1020

tgctgcgtgg gctccaagtt ttgggagcag tccgtgaggc tgggatcttg ggacagaggc     1080

atgcagtact cccactctat catcaccaat ctgctgtatc acgtggtggg ctggacagac     1140

tggaacctgg ccctgaatcc agagggcggc cccaactggg tgagaaattt cgtggatagc     1200

cccatcatcg tggacatcac caaggataca ttctacaagc agccaatgtt ttatcacctg     1260

ggccacttct ctaagtttat ccctgagggc agccagaggg tgggcctggt ggccagccag     1320

aagaacgacc tggatgccgt ggccctgatg caccctgatg gctccgccgt ggtggtggtg     1380

ctgaatcgct ctagcaagga cgtgcctctg accatcaagg atccagccgt gggatttctg     1440

gagactattt cacctggcta ttcaattcat acctacctgt ggaggaggca gtga           1494


<210>  26
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctcagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tgctacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgagtgc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  27
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synethtic construct

<400>  27
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgta tccctaagag ctttggctac agctcagtag tttgtgtctg taatgccaca      180

tactgtgact cctttgaccc ccctaccttc cctgccctgg gaaccttcag cagatatgag      240

tcaacaagat caggaaggag gatggagctg tcaatgggac ccatccaggc taatcacaca      300

ggcacaggcc tgctgctgac cctgcagcca gaacagaagt tccagaaagt gaagggattt      360

ggaggagcca tgacagatgc tgctgctctc aacatcctgg ccctgtcacc ccctgcccag      420

aatctgctgc tgaagtcata cttctctgaa gaaggaattg gatataacat catcagggtg      480

cccatggcca gctgtgactt ctccatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctcccagag gaagatacca agctcaagat ccctctgata      600

catagggcac tgcagctggc ccagaggcct gtgtcactcc tggccagccc ctggacatca      660

cccacttggc tcaagaccaa tggagctgtg aatggaaagg gatcactcaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggcagtgaca gctcagaatg agccttctgc tggactgctg      840

tcaggatacc ccttccagtg tctgggcttc acccctgaac atcagaggga cttcattgcc      900

agggacctgg gacctaccct tgccaactca actcaccaca atgtcaggct gctcatgctg      960

gatgaccaga ggctgctgct gccccactgg gccaaggtgg tgctgacaga cccagaagct     1020

gctaaatatg tgcatggcat tgctgtgcat tgctacctgg acttcctggc tccagccaag     1080

gccaccctgg gagagacaca caggctgttc cccaacacca tgctctttgc ctctgagtgc     1140

tgtgtgggct ccaagttctg ggagcagtca gtgaggctgg gctcctggga taggggaatg     1200

cagtacagcc acagcatcat cacaaacctc ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga aggaggaccc aactgggtca gaaattttgt ggactcaccc     1320

atcattgtgg acatcaccaa ggacacattc tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggctcc cagagggtgg gactggtggc ctcacagaag     1440

aatgacctgg atgcagtggc cctgatgcat cctgatggct ctgctgtggt ggttgtgctg     1500

aatagatcct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

acaatctcac ctggctactc catccacacc tacctgtgga ggaggcagtg a              1611


<210>  28
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccaca      180

tactgtgact cctttgaccc ccccaccttt cctgccctgg gcacattctc cagatatgag      240

agcacaagat ctgggagaag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcacaggcc tgctgctgac cctgcagcct gaacagaagt ttcagaaagt gaagggattt      360

ggaggggcca tgacagatgc tgctgctctg aatatcctgg ccctgtcacc ccctgcccag      420

aatctgctgc tgaagagcta cttttcagaa gaaggaattg gatataatat catcagagtg      480

cccatggcca gctgtgactt ttccatcaga acctacacct atgcagacac ccctgatgat      540

tttcagctgc acaattttag cctgcctgag gaagatacca agctgaagat acccctgatt      600

cacagggccc tgcagctggc ccagaggcct gtttcactgc tggccagccc ctggacatca      660

cccacctggc tgaagaccaa tggagctgtg aatgggaagg ggtcactgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agtttctgga tgcctatgct      780

gagcacaagc tgcagttttg ggcagtgaca gctcagaatg agccttcagc tgggctgctg      840

tcaggatacc cctttcagtg cctgggcttt acccctgaac atcagaggga ctttattgcc      900

agggacctgg gccctaccct ggccaatagc acccaccata atgtgaggtt gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gcaaaggtgg tgctgacaga ccctgaagca     1020

gctaaatatg ttcatggcat tgctgtgcat tgctacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagacaca caggctgttt cccaatacca tgctgtttgc ctctgagtgc     1140

tgtgtgggct ccaagttttg ggagcagtct gtgaggctgg gctcctggga tagagggatg     1200

cagtacagcc acagcatcat caccaatctg ctgtaccatg tggtgggctg gactgactgg     1260

aatctggccc tgaatcctga aggaggacct aactgggtca ggaattttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgtttta ccacctgggc     1380

cactttagca agtttattcc tgagggctcc cagagagtgg ggctggttgc cagccagaag     1440

aatgacctgg atgcagtggc actgatgcat cctgatggct cagctgttgt ggtggtgctg     1500

aatagatcca gcaaggatgt gcctctgacc atcaaggatc ctgctgtggg ctttctggag     1560

acaatctcac ctggctactc cattcacacc tacctgtgga gaaggcagtg a              1611


<210>  29
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccttgca tcccaaagtc tttcggctac agctccgtgg tgtgcgtgtg caacgccacc      180

tattgtgact ccttcgatcc ccctaccttt cccgccctgg gcacattttc tagatacgag      240

tctacacgca gcggccggag aatggagctg agcatgggcc ctatccaggc caatcacaca      300

ggaacaggcc tgctgctgac cctgcagcca gagcagaagt tccagaaggt gaagggcttt      360

ggcggagcca tgacagatgc agccgccctg aacatcctgg ccctgtcccc acccgcccag      420

aatctgctgc tgaagtccta cttctctgag gagggcatcg gctataacat catccgggtg      480

cccatggcca gctgcgactt ttccatcaga acctacacat atgccgatac ccctgacgat      540

ttccagctgc acaatttttc cctgccagag gaggatacaa agctgaagat ccccctgatt      600

caccgggccc tgcagctggc acagcggccc gtgagcctgc tggccagccc ctggacctcc      660

cctacatggc tgaagaccaa cggcgccgtg aatggcaagg gctctctgaa gggacagcct      720

ggcgacatct accaccagac atgggccaga tatttcgtga agtttctgga tgcctacgcc      780

gagcacaagc tgcagttctg ggccgtgaca gcacagaatg agccttctgc cggcctgctg      840

agcggctatc ccttccagtg cctgggcttt acacctgagc accagcggga ctttatcgcc      900

agagatctgg gcccaaccct ggccaactcc acacaccaca atgtgaggct gctgatgctg      960

gacgatcagc gcctgctgct gcctcactgg gccaaggtgg tgctgaccga cccagaggcc     1020

gccaagtacg tgcacggcat cgccgtgcac tgctatctgg atttcctggc acctgcaaag     1080

gccaccctgg gagagacaca ccggctgttc cctaacacca tgctgtttgc cagcgagtgc     1140

tgcgtgggct ccaagttttg ggagcagtcc gtgaggctgg gatcttggga cagaggcatg     1200

cagtactccc actctatcat caccaatctg ctgtatcacg tggtgggctg gacagactgg     1260

aacctggccc tgaatccaga gggcggcccc aactgggtga gaaatttcgt ggatagcccc     1320

atcatcgtgg acatcaccaa ggatacattc tacaagcagc caatgtttta tcacctgggc     1380

cacttctcta agtttatccc tgagggcagc cagagggtgg gcctggtggc cagccagaag     1440

aacgacctgg atgccgtggc cctgatgcac cctgatggct ccgccgtggt ggtggtgctg     1500

aatcgctcta gcaaggacgt gcctctgacc atcaaggatc cagccgtggg atttctggag     1560

actatttcac ctggctattc aattcatacc tacctgtgga ggaggcagtg a              1611


<210>  30
<211>  185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30
gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt       60

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      120

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      180

tgaat                                                                  185


<210>  31
<211>  418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31
ggatcttgct accagtggaa cagccactaa ggattctgca gtgagagcag agggccagct       60

aagtggtact ctcccagaga ctgtctgact cacgccaccc cctccacctt ggacacagga      120

cgctgtggtt tctgagccag gtacaatgac tcctttcggt aagtgcagtg gaagctgtac      180

actgcccagg caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac      240

ttagcccctg tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc      300

tcccccgttg cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc      360

tcagcttcag gcaccaccac tgacctggga cagtgaatga tccccctgat ctgcggcc        418


<210>  32
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32
ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc       60

tgaccttgga gctggggcag aggtcagaca cctctctggg cccatgccac ctccaac         117


<210>  33
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg g                                                321


<210>  34
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34
ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc       60

tgaccttgga gctggggcag aggtcagaca cctctctggg cccatgccac ctccaactgg      120

acacaggacg ctgtggtttc tgagccaggg ggcgactcag atcccagcca gtggacttag      180

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      240

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag      300

cttcaggcac caccactgac ctgggacagt gaat                                  334


<210>  35
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtgaatgat ccccctgatc tgcggcc                                          747


<210>  36
<211>  736
<212>  PRT
<213>  adeno-associated virus 3B

<400>  36

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  37
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic capsid protein

<400>  37

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  38
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic capsid protein

<400>  38

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  39
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  39

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  40
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  40
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

cgcccctgca tccctaaaag cttcggctac agctcggtgg tgtgtgtctg caatgccaca      180

tactgtgact cctttgaccc cccgaccttt cctgcccttg gtaccttcag ccgctatgag      240

agtacacgca gtgggcgacg gatggagctg agtatggggc ccatccaggc taatcacacg      300

ggcacaggcc tgctactgac cctgcagcca gaacagaagt tccagaaagt gaagggattt      360

ggaggggcca tgacagatgc tgctgctctc aacatccttg ccctgtcacc ccctgcccaa      420

aatttgctac ttaaatcgta cttctctgaa gaaggaatcg gatataacat catccgggta      480

cccatggcca gctgtgactt ctccatccgc acctacacct atgcagacac ccctgatgat      540

ttccagttgc acaacttcag cctcccagag gaagatacca agctcaagat acccctgatt      600

caccgagccc tgcagttggc ccagcgtccc gtttcactcc ttgccagccc ctggacatca      660

cccacttggc tcaagaccaa tggagcggtg aatgggaagg ggtcactcaa gggacagccc      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagt tacagttctg ggcagtgaca gctgaaaatg agccttctgc tgggctgttg      840

agtggatacc ccttccagtg cctgggcttc acccctgaac atcagcgaga cttcattgcc      900

cgtgacctag gtcctaccct cgccaacagt actcaccaca atgtccgcct actcatgctg      960

gatgaccaac gcttgctgct gccccactgg gcaaaggtgg tactgacaga cccagaagca     1020

gctaaatatg ttcatggcat tgctgtacat tggtacctgg actttctggc tccagccaaa     1080

gccaccctag gggagacaca ccgcctgttc cccaacacca tgctctttgc ctcagaggcc     1140

tgtgtgggct ccaagttctg ggagcagagt gtgcggctag gctcctggga tcgagggatg     1200

cagtacagcc acagcatcat cacgaacctc ctgtaccatg tggtcggctg gaccgactgg     1260

aaccttgccc tgaaccccga aggaggaccc aattgggtgc gtaactttgt cgacagtccc     1320

atcattgtag acatcaccaa ggacacgttt tacaaacagc ccatgttcta ccaccttggc     1380

cacttcagca agttcattcc tgagggctcc cagagagtgg ggctggttgc cagtcagaag     1440

aacgacctgg acgcagtggc actgatgcat cccgatggct ctgctgttgt ggtcgtgcta     1500

aaccgctcct ctaaggatgt gcctcttacc atcaaggatc ctgctgtggg cttcctggag     1560

acaatctcac ctggctactc cattcacacc tacctgtggc gtcgccagtg a              1611


<210>  41
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCase protein

<400>  41

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Gln 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  42
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCase protein

<400>  42

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Cys Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Cys Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  43
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCase protein

<400>  43

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Gln 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Cys Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Cys Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  44
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCase protein

<400>  44

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Gln Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  45
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCase protein

<400>  45

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Cys Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Cys Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  46
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCase protein

<400>  46

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Gln Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Cys Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Cys Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  47
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagaacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  48
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcacaaca atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  49
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagca agagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  50
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgaag cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  51
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga acaggcagtg a              1611


<210>  52
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc tgaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  53
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc tgaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaac     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  54
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aattgcctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggtgct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  55
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct gcgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtggt gcaggcagtg a              1611


<210>  56
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatctg caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgt gcgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  57
<211>  66
<212>  DNA
<213>  Simian virus 40

<400>  57
gtaaatataa aatttttaag tgtataatgt gttaaactac tgattctaat tgtttctctc       60

ttttag                                                                  66


<210>  58
<211>  208
<212>  DNA
<213>  Bos taurus

<400>  58
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctgggga                                         208


<210>  59
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59
gccaggccct gcatccctaa gagctttggc tacagctctg tggtgtgtgt gtgcaatgcc       60

acctactgtg acagctttga cccccccacc tttcctgccc tgggcacctt cagcagatat      120

gagagcacca ggtctgggag gaggatggag ctgagcatgg ggcccatcca ggctaatcac      180

actggcactg gcctgctgct gaccctgcag cctgagcaga agttccagaa agtaaagggc      240

tttggagggg ccatgactga tgctgctgct ctgaacatcc tggccctgag cccccctgcc      300

cagaatctgc tgctgaagag ctacttctct gaggagggca ttggctataa catcatcagg      360

gtgcccatgg ccagctgtga cttcagcatc aggacctaca cctatgctga cacccctgat      420

gatttccagc tgcacaactt cagcctgcct gaggaggata ccaagctgaa gatcccactg      480

atccacaggg ctctgcagct ggcccagagg cctgtgagcc tgctggccag cccctggacc      540

agccccactt ggctgaagac caatggggct gtgaatggga aggggagcct gaagggacag      600

cctggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agctgcagtt ctgggctgtg actgctgaga atgagccttc tgctgggctg      720

ctgtctggct accccttcca atgcctgggc ttcacccctg agcatcagag ggacttcatt      780

gccagggacc tgggccctac cctggccaac agcactcacc ataatgttag gctgctgatg      840

ctggatgacc agaggctgct gctgccccac tgggctaagg tggtgctgac tgaccctgag      900

gctgctaaat atgtgcatgg cattgctgtg cattggtacc tggactttct ggctcctgcc      960

aaggccaccc tgggggagac ccacaggctg ttccccaaca ccatgctgtt tgcctctgag     1020

gcctgtgtgg gcagcaagtt ctgggagcag tctgtgaggc tgggcagctg ggataggggg     1080

atgcagtaca gccacagcat catcaccaac ctgctgtacc atgtggtggg ctggactgac     1140

tggaacctgg ccctgaaccc tgagggagga cctaactggg tcagaaactt tgtggacagc     1200

cccatcattg tggacatcac caaggacacc ttttacaagc agcccatgtt ctaccacctg     1260

ggccacttca gcaagttcat ccctgagggc agccagagag tggggctggt ggccagccag     1320

aagaatgacc tggatgctgt ggctctgatg catcctgatg gctctgctgt ggtggtggtg     1380

ctgaacagga gctctaagga tgtgcctctg accatcaagg atcctgctgt gggcttcctg     1440

gagaccatca gccctggcta cagcatccac acctacctgt ggaggaggca gtga           1494


<210>  60
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc      120

aggccctgca tccctaagag ctttggctac agctctgtgg tgtgtgtgtg caatgccacc      180

tactgtgaca gctttgaccc ccccaccttt cctgccctgg gcaccttcag cagatatgag      240

agcaccaggt ctgggaggag gatggagctg agcatggggc ccatccaggc taatcacact      300

ggcactggcc tgctgctgac cctgcagcct gagcagaagt tccagaaagt aaagggcttt      360

ggaggggcca tgactgatgc tgctgctctg aacatcctgg ccctgagccc ccctgcccag      420

aatctgctgc tgaagagcta cttctctgag gagggcattg gctataacat catcagggtg      480

cccatggcca gctgtgactt cagcatcagg acctacacct atgctgacac ccctgatgat      540

ttccagctgc acaacttcag cctgcctgag gaggatacca agctgaagat cccactgatc      600

cacagggctc tgcagctggc ccagaggcct gtgagcctgc tggccagccc ctggaccagc      660

cccacttggc tgaagaccaa tggggctgtg aatgggaagg ggagcctgaa gggacagcct      720

ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct      780

gagcacaagc tgcagttctg ggctgtgact gctgagaatg agccttctgc tgggctgctg      840

tctggctacc ccttccaatg cctgggcttc acccctgagc atcagaggga cttcattgcc      900

agggacctgg gccctaccct ggccaacagc actcaccata atgttaggct gctgatgctg      960

gatgaccaga ggctgctgct gccccactgg gctaaggtgg tgctgactga ccctgaggct     1020

gctaaatatg tgcatggcat tgctgtgcat tggtacctgg actttctggc tcctgccaag     1080

gccaccctgg gggagaccca caggctgttc cccaacacca tgctgtttgc ctctgaggcc     1140

tgtgtgggca gcaagttctg ggagcagtct gtgaggctgg gcagctggga tagggggatg     1200

cagtacagcc acagcatcat caccaacctg ctgtaccatg tggtgggctg gactgactgg     1260

aacctggccc tgaaccctga gggaggacct aactgggtca gaaactttgt ggacagcccc     1320

atcattgtgg acatcaccaa ggacaccttt tacaagcagc ccatgttcta ccacctgggc     1380

cacttcagca agttcatccc tgagggcagc cagagagtgg ggctggtggc cagccagaag     1440

aatgacctgg atgctgtggc tctgatgcat cctgatggct ctgctgtggt ggtggtgctg     1500

aacaggagct ctaaggatgt gcctctgacc atcaaggatc ctgctgtggg cttcctggag     1560

accatcagcc ctggctacag catccacacc tacctgtgga ggaggcagtg a              1611


<210>  61
<211>  588
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  61
atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc       60

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta      120

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt      180

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg      240

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta      300

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt      360

tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg      420

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca      480

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc      540

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgc                   588


<210>  62
<211>  245
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  62
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggt                                                                  245


<210>  63
<211>  589
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  63
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  64
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  64
gcccgcccct gcatccctaa aagcttcggc tacagctcgg tggtgtgtgt ctgcaatgcc       60

acatactgtg actcctttga ccccccgacc tttcctgccc ttggtacctt cagccgctat      120

gagagtacac gcagtgggcg acggatggag ctgagtatgg ggcccatcca ggctaatcac      180

acgggcacag gcctgctact gaccctgcag ccagaacaga agttccagaa agtgaaggga      240

tttggagggg ccatgacaga tgctgctgct ctcaacatcc ttgccctgtc accccctgcc      300

caaaatttgc tacttaaatc gtacttctct gaagaaggaa tcggatataa catcatccgg      360

gtacccatgg ccagctgtga cttctccatc cgcacctaca cctatgcaga cacccctgat      420

gatttccagt tgcacaactt cagcctccca gaggaagata ccaagctcaa gatacccctg      480

attcaccgag ccctgcagtt ggcccagcgt cccgtttcac tccttgccag cccctggaca      540

tcacccactt ggctcaagac caatggagcg gtgaatggga aggggtcact caagggacag      600

cccggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agttacagtt ctgggcagtg acagctgaaa atgagccttc tgctgggctg      720

ttgagtggat accccttcca gtgcctgggc ttcacccctg aacatcagcg agacttcatt      780

gcccgtgacc taggtcctac cctcgccaac agtactcacc acaatgtccg cctactcatg      840

ctggatgacc aacgcttgct gctgccccac tgggcaaagg tggtactgac agacccagaa      900

gcagctaaat atgttcatgg cattgctgta cattggtacc tggactttct ggctccagcc      960

aaagccaccc taggggagac acaccgcctg ttccccaaca ccatgctctt tgcctcagag     1020

gcctgtgtgg gctccaagtt ctgggagcag agtgtgcggc taggctcctg ggatcgaggg     1080

atgcagtaca gccacagcat catcacgaac ctcctgtacc atgtggtcgg ctggaccgac     1140

tggaaccttg ccctgaaccc cgaaggagga cccaattggg tgcgtaactt tgtcgacagt     1200

cccatcattg tagacatcac caaggacacg ttttacaaac agcccatgtt ctaccacctt     1260

ggccacttca gcaagttcat tcctgagggc tcccagagag tggggctggt tgccagtcag     1320

aagaacgacc tggacgcagt ggcactgatg catcccgatg gctctgctgt tgtggtcgtg     1380

ctaaaccgct cctctaagga tgtgcctctt accatcaagg atcctgctgt gggcttcctg     1440

gagacaatct cacctggcta ctccattcac acctacctgt ggcgtcgcca gtga           1494


