                         SEQUENCE LISTING

<110>  Institut Curie
       INSERM
 
<120>  IMMUNE CELLS DEFECTIVE FOR SOCS1

<130>  B2006099EPWO

<150>  EP 20305878.9
<151>  2020-07-30

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Ala His Asn Gln Val Ala Ala Asp Asn Ala Val Ser Thr Ala 
1               5                   10                  15      


Ala Glu Pro Arg Arg Arg Pro Glu Pro Ser Ser Ser Ser Ser Ser Ser 
            20                  25                  30          


Pro Ala Ala Pro Ala Arg Pro Arg Pro Cys Pro Ala Val Pro Ala Pro 
        35                  40                  45              


Ala Pro Gly Asp Thr His Phe Arg Thr Phe Arg Ser His Ala Asp Tyr 
    50                  55                  60                  


Arg Arg Ile Thr Arg Ala Ser Ala Leu Leu Asp Ala Cys Gly Phe Tyr 
65                  70                  75                  80  


Trp Gly Pro Leu Ser Val His Gly Ala His Glu Arg Leu Arg Ala Glu 
                85                  90                  95      


Pro Val Gly Thr Phe Leu Val Arg Asp Ser Arg Gln Arg Asn Cys Phe 
            100                 105                 110         


Phe Ala Leu Ser Val Lys Met Ala Ser Gly Pro Thr Ser Ile Arg Val 
        115                 120                 125             


His Phe Gln Ala Gly Arg Phe His Leu Asp Gly Ser Arg Glu Ser Phe 
    130                 135                 140                 


Asp Cys Leu Phe Glu Leu Leu Glu His Tyr Val Ala Ala Pro Arg Arg 
145                 150                 155                 160 


Met Leu Gly Ala Pro Leu Arg Gln Arg Arg Val Arg Pro Leu Gln Glu 
                165                 170                 175     


Leu Cys Arg Gln Arg Ile Val Ala Thr Val Gly Arg Glu Asn Leu Ala 
            180                 185                 190         


Arg Ile Pro Leu Asn Pro Val Leu Arg Asp Tyr Leu Ser Ser Phe Pro 
        195                 200                 205             


Phe Gln Ile 
    210     


<210>  2
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Asn Leu Lys Gly Cys Ser Val Cys Cys Lys Ser Ser Trp 
1               5                   10                  15      


Asn Gln Leu Gln Asp Leu Cys Arg Leu Ala Lys Leu Ser Cys Pro Ala 
            20                  25                  30          


Leu Gly Ile Ser Lys Arg Asn Leu Tyr Asp Phe Glu Val Glu Tyr Leu 
        35                  40                  45              


Cys Asp Tyr Lys Lys Ile Arg Glu Gln Glu Tyr Tyr Leu Val Lys Trp 
    50                  55                  60                  


Arg Gly Tyr Pro Asp Ser Glu Ser Thr Trp Glu Pro Arg Gln Asn Leu 
65                  70                  75                  80  


Lys Cys Val Arg Ile Leu Lys Gln Phe His Lys Asp Leu Glu Arg Glu 
                85                  90                  95      


Leu Leu Arg Arg His His Arg Ser Lys Thr Pro Arg His Leu Asp Pro 
            100                 105                 110         


Ser Leu Ala Asn Tyr Leu Val Gln Lys Ala Lys Gln Arg Arg Ala Leu 
        115                 120                 125             


Arg Arg Trp Glu Gln Glu Leu Asn Ala Lys Arg Ser His Leu Gly Arg 
    130                 135                 140                 


Ile Thr Val Glu Asn Glu Val Asp Leu Asp Gly Pro Pro Arg Ala Phe 
145                 150                 155                 160 


Val Tyr Ile Asn Glu Tyr Arg Val Gly Glu Gly Ile Thr Leu Asn Gln 
                165                 170                 175     


Val Ala Val Gly Cys Glu Cys Gln Asp Cys Leu Trp Ala Pro Thr Gly 
            180                 185                 190         


Gly Cys Cys Pro Gly Ala Ser Leu His Lys Phe Ala Tyr Asn Asp Gln 
        195                 200                 205             


Gly Gln Val Arg Leu Arg Ala Gly Leu Pro Ile Tyr Glu Cys Asn Ser 
    210                 215                 220                 


Arg Cys Arg Cys Gly Tyr Asp Cys Pro Asn Arg Val Val Gln Lys Gly 
225                 230                 235                 240 


Ile Arg Tyr Asp Leu Cys Ile Phe Arg Thr Asp Asp Gly Arg Gly Trp 
                245                 250                 255     


Gly Val Arg Thr Leu Glu Lys Ile Arg Lys Asn Ser Phe Val Met Glu 
            260                 265                 270         


Tyr Val Gly Glu Ile Ile Thr Ser Glu Glu Ala Glu Arg Arg Gly Gln 
        275                 280                 285             


Ile Tyr Asp Arg Gln Gly Ala Thr Tyr Leu Phe Asp Leu Asp Tyr Val 
    290                 295                 300                 


Glu Asp Val Tyr Thr Val Asp Ala Ala Tyr Tyr Gly Asn Ile Ser His 
305                 310                 315                 320 


Phe Val Asn His Ser Cys Asp Pro Asn Leu Gln Val Tyr Asn Val Phe 
                325                 330                 335     


Ile Asp Asn Leu Asp Glu Arg Leu Pro Arg Ile Ala Phe Phe Ala Thr 
            340                 345                 350         


Arg Thr Ile Arg Ala Gly Glu Glu Leu Thr Phe Asp Tyr Asn Met Gln 
        355                 360                 365             


Val Asp Pro Val Asp Met Glu Ser Thr Arg Met Asp Ser Asn Phe Gly 
    370                 375                 380                 


Leu Ala Gly Leu Pro Gly Ser Pro Lys Lys Arg Val Arg Ile Glu Cys 
385                 390                 395                 400 


Lys Cys Gly Thr Glu Ser Cys Arg Lys Tyr Leu Phe 
                405                 410         


<210>  3
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Gly Met Ser Arg Leu Arg Asn Asp Arg Leu Ala Asp Pro Leu 
1               5                   10                  15      


Thr Gly Cys Ser Val Cys Cys Lys Ser Ser Trp Asn Gln Leu Gln Asp 
            20                  25                  30          


Leu Cys Arg Leu Ala Lys Leu Ser Cys Pro Ala Leu Gly Ile Ser Lys 
        35                  40                  45              


Arg Asn Leu Tyr Asp Phe Glu Val Glu Tyr Leu Cys Asp Tyr Lys Lys 
    50                  55                  60                  


Ile Arg Glu Gln Glu Tyr Tyr Leu Val Lys Trp Arg Gly Tyr Pro Asp 
65                  70                  75                  80  


Ser Glu Ser Thr Trp Glu Pro Arg Gln Asn Leu Lys Cys Val Arg Ile 
                85                  90                  95      


Leu Lys Gln Phe His Lys Asp Leu Glu Arg Glu Leu Leu Arg Arg His 
            100                 105                 110         


His Arg Ser Lys Thr Pro Arg His Leu Asp Pro Ser Leu Ala Asn Tyr 
        115                 120                 125             


Leu Val Gln Lys Ala Lys Gln Arg Arg Ala Leu Arg Arg Trp Glu Gln 
    130                 135                 140                 


Glu Leu Asn Ala Lys Arg Ser His Leu Gly Arg Ile Thr Val Glu Asn 
145                 150                 155                 160 


Glu Val Asp Leu Asp Gly Pro Pro Arg Ala Phe Val Tyr Ile Asn Glu 
                165                 170                 175     


Tyr Arg Val Gly Glu Gly Ile Thr Leu Asn Gln Val Ala Val Gly Cys 
            180                 185                 190         


Glu Cys Gln Asp Cys Leu Trp Ala Pro Thr Gly Gly Cys Cys Pro Gly 
        195                 200                 205             


Ala Ser Leu His Lys Phe Ala Tyr Asn Asp Gln Gly Gln Val Arg Leu 
    210                 215                 220                 


Arg Ala Gly Leu Pro Ile Tyr Glu Cys Asn Ser Arg Cys Arg Cys Gly 
225                 230                 235                 240 


Tyr Asp Cys Pro Asn Arg Val Val Gln Lys Gly Ile Arg Tyr Asp Leu 
                245                 250                 255     


Cys Ile Phe Arg Thr Asp Asp Gly Arg Gly Trp Gly Val Arg Thr Leu 
            260                 265                 270         


Glu Lys Ile Arg Lys Asn Ser Phe Val Met Glu Tyr Val Gly Glu Ile 
        275                 280                 285             


Ile Thr Ser Glu Glu Ala Glu Arg Arg Gly Gln Ile Tyr Asp Arg Gln 
    290                 295                 300                 


Gly Ala Thr Tyr Leu Phe Asp Leu Asp Tyr Val Glu Asp Val Tyr Thr 
305                 310                 315                 320 


Val Asp Ala Ala Tyr Tyr Gly Asn Ile Ser His Phe Val Asn His Ser 
                325                 330                 335     


Cys Asp Pro Asn Leu Gln Val Tyr Asn Val Phe Ile Asp Asn Leu Asp 
            340                 345                 350         


Glu Arg Leu Pro Arg Ile Ala Phe Phe Ala Thr Arg Thr Ile Arg Ala 
        355                 360                 365             


Gly Glu Glu Leu Thr Phe Asp Tyr Asn Met Gln Val Asp Pro Val Asp 
    370                 375                 380                 


Met Glu Ser Thr Arg Met Asp Ser Asn Phe Gly Leu Ala Gly Leu Pro 
385                 390                 395                 400 


Gly Ser Pro Lys Lys Arg Val Arg Ile Glu Cys Lys Cys Gly Thr Glu 
                405                 410                 415     


Ser Cys Arg Lys Tyr Leu Phe 
            420             


<210>  4
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  5
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


