               SEQUENCE LISTING

<110> PAUL SCHERRER INSTITUT

<120> Composition comprising a rapalog and a radiolabelled gastrin analogue, in particular for use in the treatment and/or diagnosis of CCKB receptor positive cancer or tumors

<130> 238797

<160> 7
<170> BiSSAP 1.3.6

<210> 1
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> radiolabeled gastrin analogue

<220> 
<221> VARIANT
<222> (1)..(1)
<223> Spacer comprising at least one selected from an amino acid containing a negative charge, Gln and D-Gln, preferably a tetra- or pentapeptide comprising at least one amino acid selected from Glu, D-Glu, beta-glutamic acid (beta-Glu), Gln, D-Gln, Asp and D-Asp, more preferably a pentapeptide comprising at least one amino acid selected Glu, D-Glu, beta-Glu, Gln, D-Gln, Asp and D-Asp

<220> 
<221> MOD_RES
<222> (1)..(1)
<223> moiety that comprises a radionuclide

<220> 
<221> VARIANT
<222> (2)..(2)
<223> Represents an amino acid selected from Glu, D-Glu, Ala, Asp, Gln, Lys, His, Arg, Ser and Asn, preferably Glu or D-Glu

<220> 
<221> VARIANT
<222> (3)..(3)
<223> Represents an amino acid selected from Ala, Ser, Val, Cys, Thr and Gly, preferably Ala or Ser

<220> 
<221> VARIANT
<222> (4)..(4)
<223> Represents an amino acid selected from Tyr, Ala, Phe, Trp and His, preferably Tyr

<220> 
<221> VARIANT
<222> (7)..(7)
<223> Represents an amino acid isosteric with Met, preferably an amino acid selected from norleucine (Nle), 2-amino-5-heptenoic acid, homo-norleucine (homo-Nle), 2-amino-4-methoxybutanoic acid, telluro-methionine (Te-Met), seleno-methionine (Se-Met) and phenylglycine (Phg), more preferably Nle or Phg
         
<220> 
<221> MOD_RES
<222> (9)..(9)
<223> AMIDATION 

<400> 1
Xaa Xaa Xaa Xaa Gly Trp Xaa Asp Phe
1               5


<210> 2
<211> 13
<212> PRT
<213> Homo sapiens

<220>
<223> minigastrin

<220> 
<221> MOD_RES
<222> (13)..(13)
<223> AMIDATION 

<400> 2
Leu Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met Asp Phe
1               5                   10


<210> 3
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<223> five C-terminal amino acids of gastrin and CCK

<220> 
<221> MOD_RES
<222> (5)..(5)
<223> AMIDATION 

<400> 3
Gly Trp Met Asp Phe
1               5         


<210> 4
<211> 8
<212> PRT
<213> Homo sapiens

<220>
<223> CCK8

<220> 
<221> MOD_RES
<222> (8)..(8)
<223> AMIDATION 

<400> 4
Asp Tyr Met Gly Trp Met Asp Phe
1               5                


<210> 5
<211> 21
<212> DNA
<213> Synthetic

<220>
<223> combined DNA/RNA molecule: "CCKBRseq1 sense RNA"

<400> 5
uauacgagua guagcaccat t                                              21


<210> 6
<211> 21
<212> DNA
<213> Synthetic

<220>
<223> combined DNA/RNA molecule: "CCKBRseq2 sense RNA"

<400> 6
ccgccaaagg auggaguact t                                              21


<210> 7
<211> 21
<212> DNA
<213> Synthetic

<220>
<223> combined DNA/RNA molecule: "control sense RNA"

<400> 7
cguacgcgga auacuucgat t                                              21


