                         SEQUENCE LISTING

<110>  CONSORCI CORPORACI SANITRIA PARC TAUL
 
<120>  IMPROVED EPITOPE FOR DETECTING AND/OR QUANTIFYING 
       ALPHA-FETOPROTEIN

<130>  906 237

<160>  45

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  1

Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu 
1               5                   10                  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  2

Pro Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln 
1               5                   10                  15      


Glu 
    


<210>  3
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  3

Pro Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln 
1               5                   10                  15      


Glu Leu Leu Glu 
            20  


<210>  4
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  4

Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu Asp Ser 
1               5                   10                  15      


Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr Ile Phe 
            20                  25                  30          


Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser Lys Met 
        35                  40                  45              


<210>  5
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  5

Thr Tyr Lys Glu Val Ser Lys Met Val Lys Asp Ala Leu Thr Ala Ile 
1               5                   10                  15      


Glu Lys Pro Thr Gly Asp Glu Gln Ser Ala Gly Cys Leu Glu Asn Gln 
            20                  25                  30          


Leu Pro Ala Phe Leu Glu Glu Leu Cys Arg Glu Lys Glu Ile Leu Glu 
        35                  40                  45              


<210>  6
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  6

Cys Arg Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp Cys Cys 
1               5                   10                  15      


Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His Lys Lys 
            20                  25                  30          


Pro Thr Pro Ala Ser Ile Pro Phe Phe Gln Val Pro Glu Pro Val Thr 
        35                  40                  45              


<210>  7
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  7

Phe Gln Val Pro Glu Pro Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp 
1               5                   10                  15      


Arg Glu Thr Phe Met Asn Lys Phe Ile Tyr Glu Ile Ala Arg Arg His 
            20                  25                  30          


Pro Phe Leu Tyr Ala Pro Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp 
        35                  40                  45              


<210>  8
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  8

Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys Cys Lys 
1               5                   10                  15      


Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr Val Thr 
            20                  25                  30          


Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys Ala Val 
        35                  40                  45              


<210>  9
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  9

Leu Asn Gln His Ala Cys Ala Val Met Lys Asn Phe Gly Thr Arg Thr 
1               5                   10                  15      


Phe Gln Ala Ile Thr Val Thr Lys Leu Ser Gln Lys Phe Thr Lys Val 
            20                  25                  30          


Asn Phe Thr Glu Ile Gln Lys Leu Val Leu Asp Val Ala His Val His 
        35                  40                  45              


<210>  10
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  10

Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly Asp Val 
1               5                   10                  15      


Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile Cys Ser 
            20                  25                  30          


Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys Leu Thr 
        35                  40                  45              


<210>  11
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  11

Ile Thr Glu Cys Cys Lys Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile 
1               5                   10                  15      


Ile His Ala Glu Asn Asp Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu 
            20                  25                  30          


Asn Arg Phe Leu Gly Asp Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu 
        35                  40                  45              


<210>  12
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  12

Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala Ser Phe 
1               5                   10                  15      


Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser Val Ile 
            20                  25                  30          


Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys Phe Gln 
        35                  40                  45              


<210>  13
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  13

Glu Leu Leu Glu Lys Cys Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln 
1               5                   10                  15      


Asp Lys Gly Glu Glu Glu Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala 
            20                  25                  30          


Leu Ala Lys Arg Ser Cys Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr 
        35                  40                  45              


<210>  14
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  14

Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu Val Ala 
1               5                   10                  15      


Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met Ala Ile 
            20                  25                  30          


Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu Ser Glu 
        35                  40                  45              


<210>  15
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  15

Ala Thr Cys Cys Gln Leu Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu 
1               5                   10                  15      


Gly Ala Ala Asp Ile Ile Ile Gly His Leu Cys Ile Arg His Glu Thr 
            20                  25                  30          


Thr Pro Val Asn Pro Gly Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala 
        35                  40                  45              


<210>  16
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  16

Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe Ser Ser 
1               5                   10                  15      


Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp Asp Lys 
            20                  25                  30          


Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala Leu Gln 
        35                  40                  45              


<210>  17
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  17

Gln Ala Gln Gly Val Ala Leu Gln Thr Met Lys Gln Glu Phe Leu Ile 
1               5                   10                  15      


Asn Leu Val Lys Gln Lys Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala 
            20                  25                  30          


Val Ile Ala Asp Phe Ser Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln 
        35                  40                  45              


<210>  18
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  18

Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe Ala Glu 
1               5                   10                  15      


Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly Val Met 
            20                  25                  30          


Trp 
    


<210>  19
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  19

Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala Ser Phe 
1               5                   10                  15      


Val His Glu Tyr 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  20

Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala Ser Phe Val His Glu Tyr 
1               5                   10                  15      


Ser Arg Arg His 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  21

Lys Asn Ile Phe Leu Ala Ser Phe Val His Glu Tyr Ser Arg Arg His 
1               5                   10                  15      


Pro Gln Leu Ala 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  22

Leu Ala Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala 
1               5                   10                  15      


Val Ser Val Ile 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  23

Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser Val Ile 
1               5                   10                  15      


Leu Arg Val Ala 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  24

Ser Arg Arg His Pro Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala 
1               5                   10                  15      


Lys Gly Tyr Gln 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  25

Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu 
1               5                   10                  15      


Lys Cys Phe Gln 
            20  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  26

Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  27

Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu 
1               5                   10                  15  


<210>  28
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  28

Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  29

Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu 
1               5                   10                  15      


<210>  30
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  30

Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu 
1               5                   10                  15      


<210>  31
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  31

Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu 
1               5                   10                  15      


Glu 
    


<210>  32
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  32

Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu 
1               5                   10                  15      


Leu 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  33

Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu 
1               5                   10                  15      


Leu 
    


<210>  34
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  34

Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu 
1               5                   10                  15      


Leu Glu 
        


<210>  35
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  35

Pro Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln 
1               5                   10                  15      


Glu Leu 
        


<210>  36
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  36

Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu 
1               5                   10                  15      


Leu Leu 
        


<210>  37
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  37

Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu 
1               5                   10                  15      


Leu Leu Glu 
            


<210>  38
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  38

Pro Gln Leu Ala Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln 
1               5                   10                  15      


Glu Leu Leu 
            

<210>  39
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  39

Ser Tyr Ala Val Ser 
1               5   


<210>  40
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  40

Ile Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Pro Leu Ile Ser 
1               5                   10                  15      


<210>  41
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  41

Arg Ser Ser Gln Arg Leu Val His Ser Asn Gly Ala Thr Tyr Leu His 
1               5                   10                  15      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  42

Lys Val Ser Lys Arg Phe Ser 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  43

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  44
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  44

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ile Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Pro Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Tyr Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Ser Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110     


<210>  45
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  45

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Val His Ser 
            20                  25                  30          


Asn Gly Ala Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    




