                         SEQUENCE LISTING

<110>  Medizinische Hochschule Hannover
 
<120>  Long non-coding RNA as therapeutic target in cardiac disorders 
       and cardiac regeneration

<130>  70896P WO

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  623
<212>  DNA
<213>  human


<220>
<221>  exon
<222>  (1)..(334)

<220>
<221>  exon
<222>  (335)..(465)

<220>
<221>  exon
<222>  (466)..(623)

<400>  1
gcctgccgac ccgggtccgg gggcccagtt ggcgcccgga ccagctctcc ggtctgcgtc       60

ctgtagatgg gaaaactgag gcctgagagg gcgcgagggc ggggacgagg ccgaggactc      120

gggttcgaat ctcgaggacg ccagtagccc gctctgaggc cgcgtggggc tggtggagga      180

gccaccggtc gggcccccaa gaccggctga cgtgggcctc gcctcgggcg actcccgccg      240

ggctagtggc tggccgtgtg gtgaccttgg gcgagttact tcgcacagcc acccaggggc      300

ctcttctcca acacgatagc actgcacccg gagggccttc agacctgagc tgaaatctac      360

accaccggct ctctgactat caggctttgg actatacttt gggctttcct gggtctctta      420

cctggcagac agcagatttt ggaacttttc agcctccata atcatttccc agaagaacca      480

caaagcataa atttccccaa aaggggaatt ttgttgatgg ctttagtcta ttccctccta      540

aaagaccagc tacaaccaaa tgaagtgaac ataacctcaa gggtgtattg tcttcataat      600

aaaagatgaa gcttagaact gga                                              623


<210>  2
<211>  709
<212>  DNA
<213>  human

<400>  2
ccggctgacg tgggcctcgc ctcgggcgac tcccgccggg ctagtggctg gccgtgtggt       60

gaccttgggc gagttacttc gcacagccac ccaggggcct cttctccaac acgatagcac      120

tgcacccgga ggataaagaa ccactgagga tatgagttat tcttcctaca gttgtacagc      180

ttgtgaacag tagagctggg gtccgagcca ggtctctgac tctgcagcct acccttgtcc      240

tgcttgaaca cactgaggaa gacaggaata acaggacatg ggtcagaagg cttggcttct      300

gctccagctt tgaagttgaa ggattaggtg acagctaaca cttgatagta ttttatggtt      360

tcaaagtgat aaccatgtaa tattttaatt gattctcagc ccattttgta gatgaggaaa      420

ctgaggctca cagatctgat gacttcctaa ttgtggcaaa ctaccagcta cacagtagct      480

gggctggctt cgaaccaggt cttttgaccc cagagtctgt gcagctcaca aataaagctg      540

attctttgac aagttaagcc tcttctcttg gattcatttt tccagtctgt gaaaatgagg      600

gattggatta gattagtagg caatcactag ttcccaggcc cttttattta aagaaaaaaa      660

ggagaaccca tagagtctgg caacttaaac ttttgctaag tatgaacac                  709


<210>  3
<211>  514
<212>  DNA
<213>  human

<400>  3
ctgactatca ggctttggac tatactttgg gctttcctgg gtctcttacc tggcagacag       60

cagattttgg aacttttcag cctccataat catcaactct gtgagggatt gttatctcca      120

ttttatggat gaggaagctg actctgagag atgactttcc aaattcatcc aactggaaga      180

aaaaggaagt ctctggggac ttgaatccag aactgtccag ctccaagtcc agggctcact      240

ctattaagcc actccatgag gaatgagtcc ctaaggaggc cacagaaggc cctaagccct      300

cttttgttct ctggaagaga gtgccatttc ttggcccttc ccaaggcctt gacaactgaa      360

gttcccagaa gaaccacaaa gcataaattt ccccaaaagg ggaattttgt tgatggcttt      420

agtctattcc ctcctaaaag accagctaca accaaatgaa gtgaacataa cctcaagggt      480

gtattgtctt cataataaaa gatgaagctt agaa                                  514


<210>  4
<211>  1066
<212>  DNA
<213>  human

<400>  4
accggtcggg cccccaagac cggctgacgt gggcctcgcc tcgggcgact cccgccgggc       60

tagtggctgg ccgtgtggtg accttgggcg agttacttcg cacagccacc caggggcctc      120

ttctccaaca cgatagcact gcacccggag ggccttcaga cctgagctga aatctacacc      180

accggctctc tgactatcag gctttggact atactttggg ctttcctggg tctcttacct      240

ggcagacagc agattttgga acttttcagc ctccataatc atgcatggaa ttcaaatcgc      300

ggagtgacag gctgtgtgtg gggctgattg tctgggtcag agacatcaca actggctggt      360

gaggagagct ttctgacaac aggagctgtc caacaaggag tgggctgctg tcaccgagga      420

gctgaagcgg ccgacggctg accttccact gggcactagg cagggcctgg atggagggag      480

tcttaaagta ggagggagaa gccaaggaaa tagctctcta gaagcatttt gtacactgaa      540

aagtgtcatt gaaacgctgt cacagttcta agaggagaca ttgctcctct gaaaaccagc      600

ctcactccct aagctgatgt atttccagaa gcagggcctg agctgccaca tgcaggccct      660

gaggacttga ggcacatcgt tctttttttg ggtctcatct gtgaatcagc cactcaaacc      720

tagtggctct cagcctgcaa gttcattcat gcaatgcagg gcttctccac tgctccccca      780

aacctcctca ggccacccct gcgtgtgcac ccaccgatat ggcctgttct gaacaggtga      840

ccctcagctg ccagcatcac tgcccttcaa aacctgactt atctctcgtg ttttacagtt      900

accatagcag aaagatttat cttcatcttt taccatttaa aaatactaat ggaattactg      960

tttttgtctg tttctgtttt gaagccatac gatttttctc tcactgccac cacatttgtg     1020

atggccttaa aaattattct taaagataaa tataattcta gaaaaa                    1066


<210>  5
<211>  2291
<212>  DNA
<213>  mouse


<220>
<221>  exon
<222>  (1)..(481)

<220>
<221>  exon
<222>  (482)..(2291)

<400>  5
aggctaaagg gacccagtag catggagggc ccctttagaa aatctaaggc cacttcaatt       60

gcttccacaa tctattccct gggcacaggg ttccttgtgt caggaaagca gatcaagtag      120

ctacggagag ttcccgagaa cacaaggacc tggcccaaag aacctgatgt tctcctttgg      180

ccagaaaact gtccacccat caacagaggt agagaatcaa tgccagagtg aatccttctt      240

accggaacat gcgatccctt tccatcctgc cttcttgtgc cctcagtttc actcagccct      300

cactgagtgc cagcctctgc ggaactcctg actgagaatc taactccttg tgggcaagga      360

cttggcccaa tctattcaca gctctgtcct cggggcctcg aggagaggct gacaatgaga      420

agaagtgcgg ggcaaatgaa agcatgagct cacactattc ttacaaggac cggagaggca      480

gggcatttcg tgtttgggat gcactaatag cctgacaagg gctcagtgca gccgagcaag      540

gctgagtgtg ttctaaaaga gtcgtctgag gattcagccg caatgaccat acactcagag      600

catagagcaa gatacagacc ctgttggtgg ccaccatgcc agaggaggtg gatttgtctc      660

ctgggtttcc tgtggaaaca gattctgtca aggcttgtgt tctgttcagt cacacaggtg      720

gctttgctta ggatgagaag gaagcctgtg agcatctggg tttgaggatg tggggaggac      780

agggatgagg gcaaggagcc tcgggcagtg ctgtgtctgg ttcccaatag gtgcagggaa      840

ggactgagac ctggcatcac agctagcctg ctggtgggcc agccctggag ggacagacaa      900

aatgcctagg tggacagaaa catctccatc tagtagagca cctgtaaagt cacattggaa      960

ccttctaccg cctgtgtttg gctcgctcct caccaaagaa gccgtggaaa ggaaggtgca     1020

acattggggc ttacatgttg gtgtccatga tggccaaaaa gctgcatgac tctacatcgc     1080

tggagttgag tgtcaagtct gaaacaagca agaaagcata cagcatggct ttccttagag     1140

gcttgcaaga acacacacaa cagcagtggg tccccagcac acccctcact tgccagatga     1200

ggaaatggac ccaggaggca aggatttgcc acatatgtag tgtttccatt tatataagag     1260

gtgtccttcc cgaaaggttc atgtataagg ggcttagtcc ctagctggtg gtggtgctgt     1320

tttgggtggt ggtgcaagct gcaagtacca ttagctggga cctagcagat ggaactaagt     1380

atactctgcc acacccacac cctccttgcc tcgaagggct gacccctctg aaaccataag     1440

cccaaataaa tcaattgttt ctttcaggtg tttggtcaga gtgaccacaa aaaaaatttt     1500

tttttcctaa ctgtgtgttg tgaactaagg aagctaatga tagaagccag acagacccag     1560

accttctcac agccagagcc ctaaccctca agtctctgac tgttcttccc tcctaggtgg     1620

tgctatgtca gccacaacct ccagtcagca ctctccactt tcagagatgc tgtctagagc     1680

tgggcaccca tccccatggc ctctatagtg agcggccatg catgctgaga gcaatggctg     1740

atttacagtg gagtgtgttg taagtatgta atgcattatg ttaattcagg ggcacacatt     1800

tatgtgtgtc cacacatgtg tgcatgcata tatggtcagt gcatctacat gtgtgtgtgc     1860

acatgaaggc cagagactga caatgagtac cctcttcagt ggctctccac cttacacact     1920

gaggcaggct ctctcccttg aaccgagagc tcacatattc acctagtgca gctggctggc     1980

ttgctccagg acgtcctgtc tctgtctccc gaatgctggg cttgccggtg ggctgccaca     2040

cccttgtgac atttacatgg gctctaggga tttgaactcc agtcctcggg cttgcatgga     2100

gagcatttaa ccttgagtca tctttccacc ccccaagatt tggagttgtt acatgagtaa     2160

aacttttaaa atttttattt aacaaataaa ttttatttat tcttttagaa tctcgttaag     2220

gatttttaga tactgatcaa atgctgacat gagattcttt taaataggtt gaataaaata     2280

tttttgagtg g                                                          2291


<210>  6
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  predicted amino acid translated from the largest open reading 
       frame (ORF) in Foxo6os

<400>  6

Met Pro Gly Leu Ser Pro Ser Leu His Leu Leu Gly Thr Arg His Ser 
1               5                   10                  15      


Thr Ala Arg Gly Ser Leu Pro Ser Ser Leu Ser Ser Pro His Pro Gln 
            20                  25                  30          


Thr Gln Met Leu Thr Gly Phe Leu Leu Ile Leu Ser Lys Ala Thr Cys 
        35                  40                  45              


Val Thr Glu Gln Asn Thr Ser Leu Asp Arg Ile Cys Phe His Arg Lys 
    50                  55                  60                  


Pro Arg Arg Gln Ile His Leu Leu Trp His Gly Gly His Gln Gln Gly 
65                  70                  75                  80  


Leu Tyr Leu Ala Leu Cys Ser Glu Cys Met Val Ile Ala Ala Glu Ser 
                85                  90                  95      


Ser Asp Asp Ser Phe Arg Thr His Ser Ala Leu Leu Gly Cys Thr Glu 
            100                 105                 110         


Pro Leu Ser Gly Tyr 
        115         


<210>  7
<211>  12
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequencing chromatograms showed the mutant junction site of 
       CRISPRed HL-1 cells gDNA.

<400>  7
tcctgaccca ag                                                           12


<210>  8
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  8
tgggga                                                                   6


<210>  9
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  9
tgggga                                                                   6


<210>  10
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  10
tgggga                                                                   6


<210>  11
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  11
tgcacgtgta                                                              10


<210>  12
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  12
atgcccagc                                                                9


<210>  13
<211>  12
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  13
gtttgtttgt tt                                                           12


<210>  14
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  14
cgggga                                                                   6


<210>  15
<211>  13
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  15
aaggtgtgaa agc                                                          13


<210>  16
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  16
ggtgccagc                                                                9


<210>  17
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  17
agtgccagc                                                                9


<210>  18
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  18
ggggga                                                                   6


<210>  19
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  19
ggggga                                                                   6


<210>  20
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  20
ggggga                                                                   6


<210>  21
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  21
cacgtgt                                                                  7


<210>  22
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  22
tacacgtgca c                                                            11


<210>  23
<211>  12
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  23
ttttatttgt tt                                                           12


<210>  24
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  24
gtcacctgca c                                                            11


<210>  25
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  25
cccggaagtg                                                              10


<210>  26
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  26
cacccggaag                                                              10


<210>  27
<211>  12
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  27
atttgtttgt tt                                                           12


<210>  28
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  28
cctgccagg                                                                9


<210>  29
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  29
agggga                                                                   6


<210>  30
<211>  8
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  30
tgtctggg                                                                 8


<210>  31
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  31
gtgccagct                                                                9


<210>  32
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of mouse Foxo6os promoter

<400>  32
gcagccaac                                                                9


<210>  33
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  33
gccccgcccc c                                                            11


<210>  34
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  34
gccccgcccc c                                                            11


<210>  35
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  35
acatggcggc g                                                            11


<210>  36
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  36
ggcgcgcgcc                                                              10


<210>  37
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  37
ggcgcgcgcc                                                              10


<210>  38
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  38
gccccgcccc ccgcc                                                        15


<210>  39
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  39
ggggcggggc                                                              10


<210>  40
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  40
ggggcggggc                                                              10


<210>  41
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  41
cgcgtg                                                                   6


<210>  42
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  42
agggcgcgag g                                                            11


<210>  43
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  43
gccccgcccc c                                                            11


<210>  44
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  44
gccccgcccc c                                                            11


<210>  45
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  45
cggcgggaag a                                                            11


<210>  46
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  46
cccccgcccc g                                                            11


<210>  47
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  47
gccccgcccc ccgcg                                                        15


<210>  48
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  48
gccccgcccg c                                                            11


<210>  49
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  49
cgggga                                                                   6


<210>  50
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  50
ggcacgagct                                                              10


<210>  51
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  51
agctcgtgcc                                                              10


<210>  52
<211>  8
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  52
cagaaggc                                                                 8


<210>  53
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  53
ctgacac                                                                  7


<210>  54
<211>  8
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  54
tgtctggc                                                                 8


<210>  55
<211>  8
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  55
tgtctggc                                                                 8


<210>  56
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  56
cgcgcgggaa c                                                            11


<210>  57
<211>  11
<212>  DNA
<213>  artificial sequence

<220>
<223>  Predicted sequence of human AC093151.3 promoter

<400>  57
cgcctggggc c                                                            11


