﻿                         SEQUENCE LISTING

<110>  Friedrich-Alexander-Universität Erlangen-Nürnberg
 
<120>  Corona Virus Spike targeting antibodies and use thereof

<130>  PCT129306I-FZGSpau

<140>  not yet assigned
<141>  2021-07-26

<150>  EP21157721.8
<151>  2020-07-31

<150>  EP20189025.8
<151>  2020-07-31

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR-567.4-VH

<400>  1

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Glu Thr Val Asp Gly Met Asp Val Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser 
    130                 135     


<210>  2
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR-567.4-VL

<400>  2

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asn Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Ser Val Thr Ile Thr Cys Arg Ala Arg Gln Asp 
        35                  40                  45              


Ile Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro 
    50                  55                  60                  


Lys His Leu Ile Tyr Ala Ala Ser Ser Leu Leu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn 
            100                 105                 110         


Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  3
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR-6.15-VH

<400>  3

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Glu Thr Val Asp Gly Met Asp Val Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser 
    130                 135     


<210>  4
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR-6.15-VL

<400>  4

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asn Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Ser Val Thr Ile Thr Cys Arg Ala Arg Gln Asp 
        35                  40                  45              


Ile Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro 
    50                  55                  60                  


Lys His Leu Ile Tyr Ala Ala Ser Ser Leu Leu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn 
            100                 105                 110         


Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  5
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR-224.2-VH

<400>  5

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Gln Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr His Cys Val Arg Glu Thr Val Asp Gly Met Asp Val Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser 
    130                 135     


<210>  6
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR-224.2-VL

<400>  6

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asn Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Ser Val Thr Ile Thr Cys Arg Ala Arg Gln Asp 
        35                  40                  45              


Ile Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro 
    50                  55                  60                  


Lys His Leu Ile Tyr Ala Ala Ser Ser Leu Leu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn 
            100                 105                 110         


Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of CVR-567.4-VH

<400>  7

Ser Tyr Gly Met His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of CVR-567.4-VH

<400>  8

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of CVR-567.4-VH

<400>  9

Glu Thr Val Asp Gly Met Asp Val 
1               5               


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of CVR-567.4-VL

<400>  10

Arg Ala Arg Gln Asp Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of CVR-567.4-VL

<400>  11

Ala Ala Ser Ser Leu Leu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of CVR-567.4-VL

<400>  12

Leu Gln His Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of CVR-6.15-VH

<400>  13

Ser Tyr Gly Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of peptide CVR-6.15-VH

<400>  14

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of peptide CVR-6.15-VH

<400>  15

Glu Thr Val Asp Gly Met Asp Val 
1               5               


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of peptide TRES-6.15-VL

<400>  16

Arg Ala Arg Gln Asp Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of peptide CVR-6.15-VL

<400>  17

Ala Ala Ser Ser Leu Leu Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of peptide CVR-6.15-VL

<400>  18

Leu Gln His Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of peptide CVR-224.2-VH

<400>  19

Gly Tyr Gly Met His 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of peptide CVR-224.2-VH

<400>  20

Val Ile Trp Tyr Asp Gly Ser Asn Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of peptide CVR-224.2-VH

<400>  21

Glu Thr Val Asp Gly Met Asp Val 
1               5               


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of peptide CVR-224.2-VL

<400>  22

Arg Ala Arg Gln Asp Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of peptide CVR-224.2-VH

<400>  23

Ala Ala Ser Ser Leu Leu Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of peptide CVR-224.2-VH

<400>  24

Leu Gln His Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  25
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of peptide CVR-567.4-VH

<400>  25
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcaggtgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcgt ctggattcac cttcagtagc tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggtatgatg gaagtaataa atactatgca      240

gactccgtga agggccgatt caccatctct agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagt cgaggacacg gctgtgtatt actgtgtgag agagacagta      360

gacggtatgg acgtctgggg ccaagggacc acggtcaccg tctcctca                   408


<210>  26
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of peptide CVR-567.4-VL

<400>  26
atgagggtcc ctgctcagct cctggggctc ctgctgctct ggttcccagg tgccagatgt       60

aacatccaga tgacccagtc tccatctgcc atgtctgcat ctgtaggaga cagcgtcacc      120

atcacttgtc gggcgaggca ggacattaac aattatttag cctggtttca gcagaaacca      180

gggaaagtcc ctaagcacct gatctatgct gcatccagtt tgctaagtgg ggtcccatca      240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtctacag cataatagtt acccgtacac ttttggccag      360

gggaccaagc tggagatcaa a                                                381


<210>  27
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of peptide CVR-6.15-VH

<400>  27
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcaggtgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcgt ctggattcac cttcagtagc tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggtatgatg gaagtaataa atactatgca      240

gactccgtga agggccgatt caccatctct agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagt cgaggacacg gctgtgtatt actgtgtgag agagacagta      360

gacggtatgg acgtctgggg ccaagggacc acggtcaccg tctcctca                   408


<210>  28
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of peptide CVR-6.15-VL

<400>  28
atgagggtcc ctgctcagct cctggggctc ctgctgctct ggttcccagg tgccagatgt       60

aacatccaga tgacccagtc tccatctgcc atgtctgcat ctgtaggaga cagcgtcacc      120

atcacttgtc gggcgaggca ggacattaac aattatttag cctggtttca gcagaaacca      180

gggaaagtcc ctaagcacct gatctatgct gcatctagtt tgctaagtgg ggtcccatca      240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtctacag cataatagtt acccgtacac ttttggccag      360

gggaccaagc tggagatcaa a                                                381


<210>  29
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of peptide CVR-224.2-VH

<400>  29
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcaggtgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcgt ctggattcac cttcagtggc tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggtatgatg gaagtaatca atactatgca      240

gactccgtga agggccgatt caccatctct agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagt cgaggacacg gctgtgtatc actgtgtgag agagacagta      360

gacggtatgg acgtctgggg ccaaggaacc acggtcaccg tctcctca                   408


<210>  30
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of peptide CVR-224.2-VL

<400>  30
atgagggtcc ctgctcagct cctggggctc ctgctgctct ggttcccagg tgccagatgt       60

aacatccaga tgacccagtc tccatctgcc atgtctgcat ctgtaggaga cagcgtcacc      120

atcacttgtc gggcgaggca ggacattaac aattatttag cctggtttca gcagaaacca      180

gggaaagtcc ctaaacacct gatctatgct gcatccagtt tgctaagtgg ggtcccatca      240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtctacag cataatagtt acccgtacac ttttggccag      360

gggaccaagc tggagatcaa a                                                381


<210>  31
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVR-567-HC: VDJ-human Cgamma1 (secreted form)

<400>  31

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Glu Thr Val Asp Gly Met Asp Val Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  32
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVR-6-HC: VDJ-human Cgamma1 (secreted form)

<400>  32

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Glu Thr Val Asp Gly Met Asp Val Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  33
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVR-224-HC:VDJ-human Cgamma1 (secreted form)

<400>  33

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Gln Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr His Cys Val Arg Glu Thr Val Asp Gly Met Asp Val Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  34
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVR-567-LC:VJ-human Ckappa

<400>  34

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys Asn Ile Gln Met Thr Gln Ser Pro Ser Ala 
            20                  25                  30          


Met Ser Ala Ser Val Gly Asp Ser Val Thr Ile Thr Cys Arg Ala Arg 
        35                  40                  45              


Gln Asp Ile Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Val Pro Lys His Leu Ile Tyr Ala Ala Ser Ser Leu Leu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


His Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  35
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVR-6-LC: VJ-human Ckappa

<400>  35

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys Asn Ile Gln Met Thr Gln Ser Pro Ser Ala 
            20                  25                  30          


Met Ser Ala Ser Val Gly Asp Ser Val Thr Ile Thr Cys Arg Ala Arg 
        35                  40                  45              


Gln Asp Ile Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Val Pro Lys His Leu Ile Tyr Ala Ala Ser Ser Leu Leu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


His Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  36
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVR-244-LC:VJ-human-Ckappa

<400>  36

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys Asn Ile Gln Met Thr Gln Ser Pro Ser Ala 
            20                  25                  30          


Met Ser Ala Ser Val Gly Asp Ser Val Thr Ile Thr Cys Arg Ala Arg 
        35                  40                  45              


Gln Asp Ile Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Val Pro Lys His Leu Ile Tyr Ala Ala Ser Ser Leu Leu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


His Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  37
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR49_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(115)
<223>  CDR3

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Val 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Tyr Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Ala Pro Ala Val Ala Gly Pro Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR49_VL


<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR3

<400>  38

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR219_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(115)
<223>  CDR3

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ser Leu Ile Glu Val 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asn Ala Glu Thr Ile Tyr Ala Arg Gly Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Ala Pro Ala Val Ala Gly Pro Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR219_VL


<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR3

<400>  40

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR328_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(115)
<223>  CDR3

<400>  41

Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Val Glu Val 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asn Ala Ala Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Tyr Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Ala Pro Ala Val Ala Gly Pro Leu Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR328_VL


<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR3

<400>  42

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR618_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(115)
<223>  CDR3

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Val 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Ala Pro Ala Val Ala Gly Pro Phe Tyr Asn Phe Tyr Tyr Gly 
            100                 105                 110         


Ile Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR618_VL


<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR3

<400>  44

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  45
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1293_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(115)
<223>  CDR3

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Val 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Ala Pro Ala Val Ala Gly Pro Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  46
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1209_VL


<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR3

<400>  46

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Ile Ile Tyr Lys Val Ser Asn Arg Phe Cys Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  47
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1293_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(115)
<223>  CDR3

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Val 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Ala Lys Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Ala Pro Ala Val Ala Gly Pro Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1293_VL


<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR3

<400>  48

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR78_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  49

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Ile Arg Ser Thr Trp Asn Trp Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  50
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR78_VL


<220>
<221>  DOMAIN
<222>  (23)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(60)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (93)..(105)
<223>  CDR3

<400>  50

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              


Glu Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  


Asn Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      


Thr Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  51
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR473_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  51

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Ile Arg Ser Thr Trp Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Phe Ser Ser 
        115                 120     


<210>  52
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR473_VL


<220>
<221>  DOMAIN
<222>  (23)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(60)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (93)..(105)
<223>  CDR3

<400>  52

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              


Glu Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Phe Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  


Asn Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      


Thr Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  53
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1082_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  53

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Ile Arg Ser Thr Trp Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  54
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1082_VL


<220>
<221>  DOMAIN
<222>  (23)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(60)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (93)..(105)
<223>  CDR3

<400>  54

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              


Glu Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  


Asn Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      


Thr Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  55
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1427_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  55

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Ile Arg Ser Thr Trp Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  56
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1427_VL


<220>
<221>  DOMAIN
<222>  (23)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(60)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (93)..(105)
<223>  CDR3

<400>  56

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln His Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              


Glu Leu Lys Lys Asp Gly Ser His Thr Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  


Asn Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      


Thr Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  57
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1471_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  57

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Ile Arg Ser Thr Trp Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Phe Ser 
        115                 120 


<210>  58
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1471_VL


<220>
<221>  DOMAIN
<222>  (23)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(60)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (93)..(105)
<223>  CDR3

<400>  58

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              


Glu Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  


Asn Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      


Thr Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  59
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1537_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  59

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Ile Arg Ser Thr Trp Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  60
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1537_VL


<220>
<221>  DOMAIN
<222>  (23)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(60)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (93)..(105)
<223>  CDR3

<400>  60

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln His Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              


Glu Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  


Asn Ile Gln Pro Glu Asn Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      


Thr Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  61
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(114)
<223>  CDR3

<400>  61

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Thr Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Tyr Tyr Gly Ser Gly Ile Tyr Tyr Asn Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  62
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR1_VL


<220>
<221>  DOMAIN
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (89)..(97)
<223>  CDR3

<400>  62

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Thr Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105     


<210>  63
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR4_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(109)
<223>  CDR3

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Leu Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asp Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Thr Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Gly Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Leu Ser Ser 
        115                 120 


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR4_VL


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(97)
<223>  CDR3

<400>  64

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR41_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  65

Gln Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Gly Ser Tyr Tyr Ser Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR41_VL


<220>
<221>  DOMAIN
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (89)..(97)
<223>  CDR3

<400>  66

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  67
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR167_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(65)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (98)..(104)
<223>  CDR3

<400>  67

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Val Ala Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


<210>  68
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR167_VL


<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR3

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Phe Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Cys Asn Arg Pro Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Ala Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  69
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR698_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(106)
<223>  CDR3

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Trp His Gly Gly Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Gly Ala Gly Asp Thr Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Gly Met Pro Pro Phe Asp Tyr Trp Gly Gln Gly Ile Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  70

<400>  70

000
   


<210>  71
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR816_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  71

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Arg Glu Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Leu Ser Ser 
        115                 120     


<210>  72
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVR816_VL


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(97)
<223>  CDR3

<400>  72

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Ile Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  73
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII1_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(105)
<223>  CDR3

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Met Glu Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Ser Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  74
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII1_VL


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  74

Glu Val Val Leu Met Gln Ser Pro Gly Thr Leu Phe Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Cys Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  75
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII2_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(111)
<223>  CDR3

<400>  75

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Asn Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Phe Gly Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  76
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII2_VL


<220>
<221>  DOMAIN
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (89)..(98)
<223>  CDR3

<400>  76

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Phe Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Glu Phe Thr Leu Thr Ile Ser Ile Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Cys Ala Thr Tyr Tyr Cys Gln Gln Pro Asn Ser Tyr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  77
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII6_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(105)
<223>  CDR3

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Asp Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Leu Phe His Cys 
                85                  90                  95      


Ala Arg Gly Glu Gly Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  78
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII6_VL


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  78

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro 
                85                  90                  95      


Arg Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII23_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(68)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (101)..(109)
<223>  CDR3

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Tyr Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ile Thr Ala Phe Asn Trp Gly Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII23_VL


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  80

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Ser Met 
            20                  25                  30          


Ser Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Thr Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asp Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  81
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII43_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(68)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (101)..(109)
<223>  CDR3

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Tyr Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ile Thr Ala Phe Asn Trp Gly Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  82
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII43_VL


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  82

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Ile Leu Ser Cys Arg Thr Ser Gln Thr Ile Ser Ser Met 
            20                  25                  30          


Ser Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Thr Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asp Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105         


<210>  83
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII145_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(65)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (98)..(109)
<223>  CDR3

<400>  83

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Cys Val Gly Gly Gly Trp Pro Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  84
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII145_Vl


<220>
<221>  DOMAIN
<222>  (23)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(60)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (93)..(100)
<223>  CDR3

<400>  84

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly 
                85                  90                  95      


Thr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  85
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII544_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(116)
<223>  CDR3

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Phe Val Leu Thr Gly Tyr Pro Tyr Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  86
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII544_VL


<220>
<221>  DOMAIN
<222>  (24)..(39)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (55)..(61)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (94)..(102)
<223>  CDR3

<400>  86

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  87
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII768_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(106)
<223>  CDR3

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Ser Pro Ser Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  88
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRII768_VL


<220>
<221>  DOMAIN
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (89)..(97)
<223>  CDR3

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  89
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII39_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(109)
<223>  CDR3

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Gly Tyr Tyr Asn Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  90
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII39_VL


<220>
<221>  DOMAIN
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (89)..(97)
<223>  CDR3

<400>  90

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Gly Ala Thr Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro His 
                85                  90                  95      


Thr Phe Gly Arg Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  91
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII179_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(103)
<223>  CDR3

<400>  91

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  92
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII179_VL


<220>
<221>  DOMAIN
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (89)..(97)
<223>  CDR3

<400>  92

Asp Ile Gln Leu Thr Gln Phe Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Ile Ile 
        35                  40                  45              


Tyr Val Ala Ser Thr Leu Gln Ser Val Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Cys Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Ser Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val His Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  93
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII208_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  93

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Tyr Gly Ser Gly Arg Met Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  94
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII208_VL


<220>
<221>  DOMAIN
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (89)..(97)
<223>  CDR3

<400>  94

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  95
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII220_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  95

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Ser Gly Ser Tyr Leu Gly Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  96
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII220_Vl


<220>
<221>  DOMAIN
<222>  (23)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (92)..(100)
<223>  CDR3

<400>  96

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  97
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII631_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(114)
<223>  CDR3

<400>  97

Gln Ala Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Glu Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Tyr Asp Leu Leu Thr Gly Tyr Tyr Gly Phe Asn Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  98
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII631_VL


<220>
<221>  DOMAIN
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (89)..(97)
<223>  CDR3

<400>  98

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Ala 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Phe Leu Ile 
        35                  40                  45              


Tyr Val Ala Thr Ser Leu His Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln Asp Tyr Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  99
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII683_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(114)
<223>  CDR3

<400>  99

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  100
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII683_VL


<220>
<221>  DOMAIN
<222>  (24)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (51)..(57)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (90)..(98)
<223>  CDR3

<400>  100

Glu Ile Val Leu Met Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  101
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide CVRIII35_VH


<220>
<221>  DOMAIN
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  DOMAIN
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  DOMAIN
<222>  (99)..(110)
<223>  CDR3

<400>  101

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Gly Gly Gly Arg Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Glu Met Ala Thr Ile Arg Asp Ala Phe Asp Met Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  102

<400>  102

000


