SEQUENCE LISTING


<110> Arno Thaller

<120> Pharmaceutical Formulation Comprising a Combination of Recombinant 
      Newcastle Disease Viruses for the Treatment of Cancer    

<130> 92539/PCT

<150> EP 20187938.4
<151> 2020-07-27

<160> 67



<210> 1
<211> 15186
<212> DNA
<213> Newcastle disease virus


<220> 
<223> STRAIN MTH-68/H

<400> 1
accaaacaga gaatccgtga gatacgataa aaggcgaagg agcaatcgaa gtcgtacggg       60

tagaaggtgt gaatctcgag tgcgagaccg aagcttaaac tcgagagagc cttctgccaa      120

catgtcttcc gtatttgacg agtatgaaca gctcctcgcg gctcagactc gccctaatgg      180

agctcacgga ggaggagaga aggggagcac cttaaaagtt gaagtcccgg tattcactct      240

taacagtgac gacccagaag atagatggaa ctttgcagta ttctgtctta ggattgctgt      300

tagcgaagat gccaacaaac cactcagaca aggtgctctc atatctctct tatgctccca      360

ttctcaagtg atgaggaacc atgtcgccct tgcagggaaa cagaatgagg ccacactggc      420

tgttcttgag atcgatggtt tcaccaacag cgtgcctcaa tttaacaaca ggagtggagt      480

gtctgaggag agagcacaga gattcttgat gatagcaggg tccctccctc gggcatgcag      540

caacggtacc ccgttcatca cagctggggt tgaagatgat gcaccagaag acatcactga      600

tactctggaa agaatcatct ctatccaggc tcaagtatgg gtcacggtag caaaggccat      660

gactgcatat gagacagcgg atgagtcgga aacaagaaga atcaataagt atatgcagca      720

aggcagagtc caaaagaagt acatcctcca ccccgtatgt aggagcgcaa ttcaactcac      780

gattagacaa tctctggcag tccgcatttt cttggttagc gagcttaaga gaggccgcaa      840

cacggcaggt ggaagttcca cttattatag cttggtaggg gacatagact catacatcag      900

gaacaccggg cttactgcat tcttcctgac actcaggtat ggaattaaca ccaagacatc      960

agcccttgca ctcagcagcc tcgcaggcga tatccaaaaa atgaagcagc tcatgcgtct     1020

atatcggatg aaaggagata atgcgccgta catgacactg ctcggtgaca gtgaccagat     1080

gagctttgca ccggctgagt atgcacaact ctactctttt gcaatgggta tggcatccgt     1140

cctagacaaa ggaactggca agtaccagtt cgccagagac tttatgagca catcattctg     1200

gagacttgga gtagagtatg ctcgggctca gggaagcagc atcaatgagg atatggctgc     1260

cgagctaaag ctgaccccag cggcaaggag gggcctggca gctgctgccc aacgagcgtc     1320

cgaggagacc ggcagcatgg acattcccac tcaacaagct ggggtcctca cagggctcag     1380

cgacggaggc cctcaagccc cacaaggtgg actgaacagg tcgcaagggc aaccggacgc     1440

cggagatggg gagacccaat ttttagattt gatgagagca gtggcaaata gtatgagaga     1500

agcgccaaac tctgtgcaga acaccactca gcaggagcct ccatctactc ctgggccatc     1560

tcaagacaac gacaccgact ggggatactg accgacaaca ctcagcctgc ctccatcgaa     1620

ttatctcgat tcttctgcct gtaacctaac ccctggtcca cagtctcaca cggccaaacc     1680

cgcaaacgag cccccccctc tctccccccc cctccagcca cacggctcca accgcccaaa     1740

acaacacggg cacaactcga ctcactcata atctacacag agccgaagat cttagaaaaa     1800

aatacgggta gaagagagac attcagagat caggacaaat catcagggtc tccgctctcc     1860

cctctaccca gcagaccaga gtgaagatgg ccaccttcac ggatgcagag atcgacgatc     1920

tatttgaaac cagtggaact gtcattgaca gcataattac ggcccaaggc aacccagtag     1980

agactgttgg aaggagcgca atcccacaag gcaaaactaa agcattgagt gcagcatggg     2040

agaaacatgg aagcacccaa ccgccggccg gccaagacac ccctgatcga atggacagat     2100

cagacaaaca accatcccca cccgaacagg caaccacaca caacagcccg ccagccacat     2160

ccaccgacca gccccccacc caggccgcag gcgaagccgg tgacacacag ctcaagactg     2220

gagcaagcaa ctccctcctg tcgatgctcg acaagcttag caataaatcg tccaatgcta     2280

aaaagggccc acggtcgagt ccccaggaag ggcaccacca acctccgacc cagcagcaag     2340

ggagtcaaca gagccgcgga aacagtcagg agagatcgca aaaccaggtc aaggccgcct     2400

ctggagacca gggcacagac gcgaacacag catatcatgg acaatggaag gagtcacaac     2460

catcagctgg tgcaatccct catgctctcc ggtcagggca gagccaagcc aatactcctg     2520

catctgtgga tcatgtccag ctacctgtcg actttgtgca ggcgatgatg tctatgatgg     2580

aggcgatatc acagaaggta aataaagtcg actatcagct agaccttgtc tcaaagcaga     2640

catcctccat ccccatgatg cgatctgaaa tccaacagct gaaaacatcc gttgcggtca     2700

tggaagccaa cctgggcatg atgaagattc tggaccctgg ttgtgctaac gtttcatctt     2760

taagtgacct acgggcggtc gcccgctctc acccagtttt agtttcaggc cccggagacc     2820

catctcctta tgtgacacaa gggggtgaat tgatactcaa taaactctcg caaccagtgc     2880

aacatccttc tgagttgatt aaacctgcca cgataagcgg gcctgatata ggagtggaga     2940

aggacactgt ccgtgcattg atcacctcac gcccaatgca tccgagctct tcagctaagc     3000

tcctgagtaa gctggatgca gccgggtcga tagaagaaat taggaaaatc aaacgccttg     3060

cgctgaatgg ctgatcacta ctacaacccg caacgggttc ccgtttatct attgtcacaa     3120

ggaacccgcc ccgagccctc ctctataaac ccaagattca aggctccaag cgataacctt     3180

ctcccgcctc ttccatccca ctgaatgatc gcgcagctgc aattaatcta gcaacattaa     3240

agattaagaa aaaatacggg tagaatcgga gtgcaccgat tgtgccaaga tggactcatc     3300

taggacaatt gggttatact ttgattctgc ccttccttct agcaacctgt tagcattccc     3360

gattgtctta cgagatgtag gagatggaaa gaagcaaatt actccgcaat ataggatccg     3420

gcgtcttgac tcgtggacag acagtaaaga agactcggta ttcatcacta cctacggatt     3480

catcttccag gttgggaatg aagaagtcac tgtcggcatg atcaatgata atcccaagcg     3540

agagttactc tccgctgcga tgctctgcct aggaagcgtc ccgaatgttg gagatcctgt     3600

tgagctggca agggcctgcc tcactatggt ggtaacatgc aagaagagtg caactaatac     3660

tgagagaatg gtcttctcag tagtgcaggc accccgggtg ctgcaaagct gtagggtcgt     3720

ggcagacaaa tactcgtcag tgaatgcagt taagcacgtg aaagcaccag agaagatccc     3780

tgggagtgaa accctagagt acaaggtgaa ttttgtctct ttgactgtgg tgccgaagaa     3840

ggatgtctac aagatcccaa ccgcagtatt gaaggtatcc ggctcgagcc tgtataatct     3900

tgcgctcaat gtcactattg atgtggaggt agacccaaag agcccgttag tcaagtccct     3960

ttctaggtcc gacagtggat actatgctaa tctcttctta catatcggac ttatgtccac     4020

tgtagataag aggggaaaga aagtgacatt tgaccagctg gagaggaaga taaggagact     4080

tgatctatct gtcgggctca gtgatgtgct cggaccttct gtgcttgtga aggcgagagg     4140

tgcacggact aggctgctgg cacctttctt ctctaacagc gggacagcct gctaccctat     4200

agcaaatgcc tctcctcagg tagctaagat actctggagt cagaccgcgt gcctgcggag     4260

tgtaaaaatc attattcaag cgggcaccca acgcgctgtc gcagtgactg ctgaccatga     4320

ggttacctct actaagatag agaagaggca taccatcgct aaatacaatc ccttcaagaa     4380

ataggccgta tccctgagac tgcaattcac ccgccttccc aaaacaccat gacaccagat     4440

aatgatctgt cttgattact tacagttagt ttccctgtct atcaaattag aaaaaacacg     4500

ggtagaagag ttcggatccc ggccggcgca ccaaaagcgc aagatgggcc ccagatcttc     4560

taccaggatc ccagtacctc taatgctgac catacggatc acgctggcac tgagttatgt     4620

ccgtctgaca agttctcttg atggcaggcc tcttgcagcc gcagggatcg tggtaacagg     4680

ggataaagca gttaacatat acacctcatc ccagacaggg tcaatcatag tcaagttact     4740

cccaaatatg cccaaggaca aagaggcatg tgcaaaagcc ccattggagg cttacaacag     4800

gacactgact actttgctta ccccccttgg tgattctatc cgcaggatac aagagtctgt     4860

gactacatcc ggaggaagga gacagagacg ctttataggt gccattattg gcagtgtagc     4920

tctaggggtt gcaacagctg cacagataac ggcagcctcg gctctgatac aagccaacca     4980

gaatgctgct aacatcctcc ggcttaagga gagcattgct gcaaccaatg aagctgtaca     5040

cgaggtcact ggcggattgt cacagttagc agtggcagtt ggaaagatgc agcaatttgt     5100

taatgaccag tttaataaca cagctcaaga gttggactgt ataaaaatta cacagcaggt     5160

tggtgtagaa ctcaacttat acttaactga attgactaca gtgttcgggc cacaaatcac     5220

ttcccctgcc ttaactcagt tgactgttca ggctctttac aatctggctg gtggtaatgt     5280

agattacttg ttgactaagt taggtgtagg gaacaaccag ctcagctcat tgattggtag     5340

cggcttgatc accggtaacc ctatttttta cgactcacag actcaactct tgggcataca     5400

ggtgacttta ccctcagtcg ggaacctaaa taatatgcgt gccacctact tggagacctt     5460

gtctgtaagc acaacaaagg gatttgcctc agcacttgtc ccaaaagtag tgacacaggt     5520

cggttctgtg atagaagagc ttgacacctc atactgtata gaagctgatt tggatttata     5580

ttgtacaaga atagtgacat tccctatgtc ccctggtatt tattcctgtt tgagcggcaa     5640

tacatcggct tgcatgtatt caaggactga aggcgcactt actacaccat acatgactct     5700

caaaggctca gttgttgcca attgccagat gacaacatgt agatgtgcag accccccggg     5760

tatcatatca caaaattatg gagaggctgt gtctctaata gataagcact catgcaatgt     5820

cgtatcctta gacgggataa ctttgaggct cagtggggaa tttgatgcaa cttatcaaaa     5880

gaatatctca atattagatt ctcaagtact agtgacaggc aatctcgata tctcaactga     5940

gcttgggaat gtcaaccact caataagtaa tgctttggat aagttagagg aaagcaacag     6000

caaactagac aaagtcaatg tcaaactgac cagcacatct gctctcatta cctatattgt     6060

tttaactgtc atatctcttg ttcttggtat gcttagcctg gttctagcat gctatctgat     6120

gtacaagcaa aaagcgcaac gaaagacctt gttgtggctt ggaaataata ccctagatca     6180

gatgagagct actacaaaaa tgtgaatgca gatgagaggc agaggtatcc ccaatagcaa     6240

tctgtgtgtc aattctggca gcctgttaat cagaagaatt aagaaaaaac taccggatgt     6300

aggtgaacaa aagggaatat acgggtagaa cggcctgaga ggccacccct caatcgggag     6360

ccaggcccca ctacgtccgc tctaccgcat caccaacagc agtcttcagt catggacagc     6420

gcagttagcc aagttgcgct agagaatgat agaagagaag cgaataatac atggcgcttg     6480

gttttccgga tcgcagcctt acttttactg gtaataacct tagccgtctc tgcagtcgcc     6540

ctggcatata gtatggaggc tagcacacct ggcgaccttg taagcatacc gactgcgatc     6600

tctagggcag aggaaaggat tacatctgca ctcggttcca atcaagatgt agtagatagg     6660

atatacaagc aagtggccct tgagtctcca ttggcactgc taaataccga atctataatt     6720

atgaatgcaa taacgtctct ctcttatcaa atcaatggag ccacaaataa tagcgggtgt     6780

ggggcacctg ttcatgaccc agattacatc ggggggatag gtcaagaact tattgtagat     6840

gatacgagtg acgtcacatc attttatccc tctgcattcc aagaacacct gaattttatc     6900

ccggcgccca ctacaggatc aggctgcact cggataccct cattcgacat gagtgctacc     6960

cattactgtt acactcacaa tgtgatattg tctggctgca gagatcactc acactcacat     7020

cagtatttag cacttggtgt gcttcggaca tctgcaacag ggagggtatt cttttctact     7080

ctgcgttcca tcaacttgga tgacgcccaa aatcggaagt cttgcagtgt gagtgcaact     7140

cctttaggtt gtgatatgct gtgctctaaa atcacagaga ctgaggaaga ggattataaa     7200

tcagttatcc ccacatcgat ggtacatgga aggttagggt ttgacggcca ataccatgag     7260

aaggacctag acgtcacaac actatttagg gactgggtgg caaattaccc aggagtagga     7320

ggtgggtctt ttattaacaa tcgcgtatgg ttcccggtct acggagggct aaaacccagc     7380

tcgcctagtg acactgcaca agaagggaga tacgtaatat acaagcgata caatgacaca     7440

tgcccggatg agcaagatta ccagattcgg atggctaagt catcgtataa gcctaggcgg     7500

tttggtggaa aacgcgtaca gcaggccatc ctatccatca aggtgtcaac atccttgggt     7560

gaggacccgg tgttgactgt accgcctaat acggtcgcac tcatgggggc cgaaggcaga     7620

gttctcacag tggggacatc tcatttctta tatcagcgag ggtcatcata cttctctccc     7680

gctttgttat accctatgac agtcaacaac aaaacagcca ctcttcataa tccttataca     7740

ttcaatgctt tcactcggcc aggtagtgtc ccttgccagg cttcagcaag atgccccaac     7800

tcatgtgtta ccggagtcta tactgatcca tatcccttag tcttccatag gaaccacacc     7860

ttgcgagggg tattcggaac aatgcttgat gacgaacaag caagactcaa ccctgtatct     7920

gcagtatttg ataacatatc ccgcagtcgc ataactcggg taagttcaag cagtaccagg     7980

gcagcataca cgacatcaac gtgttttaaa gttgtcaaga ccaataaaac ctattgcctc     8040

agcattgcag aaatatccaa taccctcttc ggggaattca gaattgtccc cttactagtt     8100

gagattctca aggatggtgg ggtttaagaa gctaggaatg gtcggttgag tcaaccgtga     8160

gaaggcgggg aagatgatat tgcatcatct atcttctgta acaccaagaa tcaaatcgaa     8220

taccagtgcg agctcgaatc ctacgctgcc agtcagccat aatcggctgg tgctaatgtg     8280

gttagcctga atcttgtcga tagtcacttg attaagaaaa aatgtggacg gtagtgaaat     8340

ataaggcaaa gcagctcaca gaggacagca cgggtaggac atggcgggct ccggacccga     8400

aagggcagag catcagatta tcctaccaga gtcacatctg tcctcaccat tggtcaagca     8460

taaattgctt tattactgga aattaactgg gctaccgctt cctgacgaat gtgacttcga     8520

ccatcttatt atcagccgac aatggaagaa ggtacttgaa tcggccaccc ctgacattga     8580

gagaatgata aaactagggc gggcagtaca ccagactctc aaccacaatt ccaggataac     8640

cggagtactc catccccggt gtttagagga actggctagt attgaggttc ctgattcaac     8700

caacaaattt cggaagatcg aaaaaaagat ccagattcac aacacaaggt atggagaact     8760

gttcacaaga ttatgcacgc atgtagaaaa gaaactattg gggtcatctt ggtctaacaa     8820

tgtcccacgg tcagaggaat tcaacagcat ccgtacagat ccggcatttt ggtttcactc     8880

aaaatggtcc acagccaaat ttgcatggct ccatataaaa caggtccaga ggcatctgat     8940

tgtagcagca agaacaaggt ccgcagtcaa caaattagtg acgctgaccc ataaggtagg     9000

ccaaatcttt gttactcctg agcttgtcat tgtgacacat acagatgaga acaagttcac     9060

gtgtcttacc caggaacttg tgttgatgta tgcagatatg atggagggca gagatatggt     9120

cagcataata tcatccacgg cggcacatct taggagctta tcagagaaaa ttgatgatat     9180

tctgcggtta gtagatgctc tggcaagaga tttgggcaat caagtctacg atgttgtagc     9240

actaatggag ggattcgcat acggcgctgt tcagctgctt gaaccgtcag gtacatttgc     9300

gggggatttc ttcgcattca acctgcagga gctcaaagat actctaaccg gactcctccc     9360

caaggatatc gcagaatctg tgactcacgc aatcgcaacc atattctctg gcttagaaca     9420

aaatcaagca gctgagatgt tgtgcctgtt gcgtctgtgg ggtcacccac tactcgagtc     9480

ccgtattgca gcaaaagcag ttaggagtca aatgtgcgca ccaaaaatgg tagactttga     9540

tatgatcctc caggtattat ctttctttaa aggaacaatc atcaatggat atagaaagaa     9600

gaatgcaggc gtgtggccac gtgtcaagat agatacgata tacgggaagg tcatagggca     9660

gctacacgca gattctgcag agatttcaca tgatgtcatg ttgagggaat acaagagttt     9720

atctgcactt gaattcgagc catgtataga gtatgaccct gtcaccaatc tgagcatgtt     9780

tttaaaagac aaggcaatcg cacacccgaa agacaactgg ctcgcttcgt ttaggcgaaa     9840

ccttctctct gaggaccaga agaaacatgt aagagaggca acctcaacta accgcctctt     9900

gatagagttc ttagagtcaa atgattttga tccatataaa gagatggaat atctgacgac     9960

ccttgagtac ctaagagatg ataatgtggc agtatcatac tcactcaaag aaaaagaggt    10020

gaaagttaat gggcggattt tcgcaaagct aacaaataga ttaaggaatt gtcaggtaat    10080

ggcagaaggg atcctagctg accagattgc acctttcttc cagggaaatg gggtcattca    10140

ggatagcata tctttgacta aaagtatgct agcgatgagt caactgtctt tcaacagcaa    10200

caagaaacgt attactgact gcaaagaaag agtatcctca aaccgcaatc atgatccgaa    10260

gagcaagaat cgtcggagag ttgccacttt tgtaactacc gacctgcaaa agtattgtct    10320

caattggaga tatcagacag tcaagctgtt cgctcatgcc atcaatcagc tgatgggctt    10380

acctcacttc ttcgagtgga ttcatcttag actaatggat actacgatgt ttgtagggga    10440

ccctttcaat cctccaagtg accctacgga ctgtgatcta tcaagagtcc caaatgatga    10500

catatatatt gtcagtgcta ggggaggcat tgagggatta tgccagaagc tatggacaat    10560

gatctcaatt gctgcaatcc agcttgctgc agcaagatca cattgtcgcg ttgcctgtat    10620

ggtacaaggc gacaatcaag taatagctgt aacgagagag gtaagatcag atgactcccc    10680

agagatggtg ttaacacaat tgcatcaagc cagtgataat ttcttcaagg aattgattca    10740

tgtcaatcat ttgatcggcc ataatttgaa ggatcgtgaa accatcaggt cagacacgtt    10800

cttcatatac agcaaacgaa tattcaaaga tggagcaata ctcagtcagg tcctcaaaaa    10860

ctcatctaaa ttagtgctaa tatcaggcga ccttagtgaa aacactgtaa tgtcttgtgc    10920

caacattgca tctactgtag cacggttatg cgagaacggg cttcctaagg atttctgtta    10980

ttacttaaac tacttaatga gttgcgtgca gacatacttc gattccgaat tttccatcac    11040

caacaactcg caactcgatt ctaaccagtc gtggatagag gacatttctt ttgtgcactc    11100

atatgtcctg acccctgctc aactgggggg actgagtaac cttcaatact caaggctcta    11160

cacaaggaac atcggcgacc cgggaaccac tgctttcgca gagatcaaga gattagaggc    11220

agtggggtta ctgagtccta gcattatgac taacatctta actaggccgc ctggaaatgg    11280

agattgggcc agtctgtgca acgatccata ctcctttaat tttgagactg tcgcaagccc    11340

aaatattgtc cttaagaaac atacacaaag agtcctattt gaaacttgct cgaatccctt    11400

attatctgga gtgcacacag aggataatga ggcagaagag aaggcattgg ctgaattctt    11460

gctcaatcaa gaaatgattc atccacgtgt cgcgcatgct atcatggaag caagctctgt    11520

aggtaggaga aagcaaattc aggggcttgt tgacacaaca aacaccgtga ttaagattgc    11580

actgactagg aggccactcg gcatcaagag gctgatgcgg atagtcaatt actcgagcat    11640

gcatgcaatg ctatttagag atgatgtttt ctcgtctaat agatccaacc atcccttagt    11700

ctcttctgat atgtgttctc tgacactggc agactatgca cggaacagaa gctggtcacc    11760

tttgacaggg ggtagaaaaa tactgggtgt atctaatcct gataccatag aacttgtaga    11820

gggtgagatc cttagtgtca gtggagggtg cactagatgt gacagtgggg atgaacagtt    11880

tacttggttc catcttccaa gcaatataga gctaaacgat gacaccagca agaatcctcc    11940

aatgagagtg ccatatctcg ggtcaaagac tcaagagagg agagccgcct cgcttgcgaa    12000

aatagctcat atgtcaccac acgtgaaggc ggctctaagg gcgtcatctg tgttaatctg    12060

ggcttatggg gacaacgaaa taaactggac tgctgccctt aagattgcaa ggtctcggtg    12120

caacataagc tcagagtatc ttcgactatt gtcacccttg cctacagctg ggaatctcca    12180

acatagattg gacgacggca taactcagat gacattcacc cctgcatctc tatacagggt    12240

gtcaccttac attcatatat ctaatgattc tcaaaggcta tttactgaag aaggagtcaa    12300

agaggggaat gtggtttatc agcaaatcat gctcttgggt ttgtccttaa ttgagtcact    12360

cttcccaatg acaacaacca agacatatga tgaaatcaca ttgcacctcc acagtaaatt    12420

tagctgctgt atcagggaag cacctgttgc agttcctttc gagctactcg gggtggcacc    12480

ggaactaagg gcagtaacct caaataagtt tatgtatgat cctagccctg tatcagaggg    12540

agactttgcg agacttgact tagctatctt taagagttat gaacttaatt tagagtcata    12600

ttccacaata gagctaatga acgttctttc aatatctagt gggaagttga ttggccagtc    12660

tgtggtttct tatgatgaag atacctccat aaagaatgac gctataatag tgtatgacaa    12720

cacacggaat tggatcagcg aagctcagaa ttcagatgtg gtccgcctat tcgagtatgc    12780

ggcactcgaa gtgctcctcg actgttctta tcaactctac tatctgagag taagaggcct    12840

aaacaatatc gtcctgtaca tgagtgattt atacaagaat atgccaggaa ttctactctc    12900

taatattgca gccacaatat ctcaccctgt catccattca aggttgaatg cagtaggtct    12960

ggtcaaccat gacgggtcac accaacttgc agacacagat ttcattgaaa tgtctgcaaa    13020

gctgctagtc tcttgcactc gacgcgtggt ctcaggttta catgcaggga ataagtatga    13080

cctgctgttt ccatctgtct tggatgataa cctaagtgag aagatgcttc agttgatatc    13140

ccaattatgc tgtctgtata cggtgctctt tgctacaaca agagaaatcc cgaaaataag    13200

aggcttatct gcagaagaga aatgttcagt acttactgag tacctactgt cagatgctgt    13260

gaaaccgtta cttgggtccg agcaagtgag ctctatcatg tctcccaaca tagttacgtt    13320

cccagccaat ctgtattaca tgtctaggaa gagccttaat ttgatcaggg agagagagga    13380

cagggatact atcttggcat tgttgttccc tcaagaaccg ctgctcgagt ttcctctggt    13440

acgagatatt ggtgctcgtg taaaagatcc atttacccga caacctgcgg cgtttttaca    13500

agagttagat ttgagtgctc cggcaaggta tgacgcattc acaatcagtc aggcgcattc    13560

tgaacacata ttgccaaacc cagaggaaga tcacttagta cgatacttgt tcagaggaat    13620

agggactgcg tcctcctctt ggtataaggc atcccatctt ctttctgtac ccgaggtcag    13680

atgtgcaagg catgggaact ccttatattt agcagaagga agtggagcca tcatgagtct    13740

tctcgaattg catataccac acgaaactat ctattacaat acacttttct cgaacgagat    13800

gaacccccca cagcgacatt tcggaccaac tccaacacag tttctgaatt cggttgtttt    13860

taggaattta caggcggaag taccatgcaa ggatggattt gtccaggagt tccgtccgtt    13920

atggagagag aatacagaag aaagcgatct gacctcagat aaagcagtgg gatatatcac    13980

atctgtagtg ccgtacaggt ctgtatcatt gctgcattgt gacattgaaa tccctccagg    14040

atctaatcaa agcttactag atcagctggc taccaatctg tctctgattg ccatgcattc    14100

tgtgaaggag ggcggggtcg tgattatcaa agtactgtat gcaatgggat attacttcca    14160

tctactcatg aacttgttta ctccatgttc cacgaaagga tatattctct ctaatggcta    14220

tgcctgtaga ggggatatgg agtgttacct gatatttgtc atgggctacc taggcgggcc    14280

tacatttgta catgaggtgg tgaggatggc aaaaacgcta gtacagcggc atggcacact    14340

tttgtctaag tcagatgaga ttacactgac taggttattt acttcacagc aacagcgtgt    14400

aacagacatc ctatccagcc ctttaccgag actaatgaag tacttgagag agaatattga    14460

tactgcactg attgaagccg ggggacagcc tgtccgtcca ttctgtgcag agagtttagt    14520

gagcacacta acagacatga ctcagacaac ccagatcatc gccagccaca ttgatacagt    14580

cattcgatct gtgatctata tggaagcaga gggtgatctt gctgacacag tattcttatt    14640

taccccttac aacctctcta tggacgggaa aaagagaaca tcacttaaac agtgcacaag    14700

acagatctta gaggtcacaa tactgggtct cagagtcaaa aatctcaata aagtaggtga    14760

tgtaatcagc ctagtactca gaggtatgat ttctctggag gaccttctcc cactgagaac    14820

ctacttgaag tgtagtacct gccctaagta tttgaaggct gtcctaggta ttaccaaact    14880

caaagaaatg ttcacagacg cctctttatt atacttgact cgtgctcaac aaaaattcta    14940

catgaaaact ataggcaatg cagtcaaggg atactatagt aactgtgact cttaaaggca    15000

accacatatc aataggccct ctttctagcc gatcgtattc ttgttgactt cattatacca    15060

tattagaaaa aaattgaatt ccgacccttt aagactcgta ttcggattca aataattatc    15120

tcagaaaaaa agtgcacgta gttgttcttg attatagtcc cgtcattcac caagtctttg    15180

tttggt                                                               15186




<210> 2
<211> 15186
<212> DNA
<213> Newcastle disease virus

<220> 
<223> Mut HN(F277L)/M(G165W)

<400> 2
accaaacaga gaatccgtga gatacgataa aaggcgaagg agcaatcgaa gtcgtacggg       60

tagaaggtgt gaatctcgag tgcgagaccg aagcttaaac tcgagagagc cttctgccaa      120

catgtcttcc gtatttgacg agtatgaaca gctcctcgcg gctcagactc gccctaatgg      180

agctcacgga ggaggagaga aggggagcac cttaaaagtt gaagtcccgg tattcactct      240

taacagtgac gacccagaag atagatggaa ctttgcagta ttctgtctta ggattgctgt      300

tagcgaagat gccaacaaac cactcagaca aggtgctctc atatctctct tatgctccca      360

ttctcaagtg atgaggaacc atgtcgccct tgcagggaaa cagaatgagg ccacactggc      420

tgttcttgag atcgatggtt tcaccaacag cgtgcctcaa tttaacaaca ggagtggagt      480

gtctgaggag agagcacaga gattcttgat gatagcaggg tccctccctc gggcatgcag      540

caacggtacc ccgttcatca cagctggggt tgaagatgat gcaccagaag acatcactga      600

tactctggaa agaatcatct ctatccaggc tcaagtatgg gtcacggtag caaaggccat      660

gactgcatat gagacagcgg atgagtcgga aacaagaaga atcaataagt atatgcagca      720

aggcagagtc caaaagaagt acatcctcca ccccgtatgt aggagcgcaa ttcaactcac      780

gattagacaa tctctggcag tccgcatttt cttggttagc gagcttaaga gaggccgcaa      840

cacggcaggt ggaagttcca cttattatag cttggtaggg gacatagact catacatcag      900

gaacaccggg cttactgcat tcttcctgac actcaggtat ggaattaaca ccaagacatc      960

agcccttgca ctcagcagcc tcgcaggcga tatccaaaaa atgaagcagc tcatgcgtct     1020

atatcggatg aaaggagata atgcgccgta catgacactg ctcggtgaca gtgaccagat     1080

gagctttgca ccggctgagt atgcacaact ctactctttt gcaatgggta tggcatccgt     1140

cctagacaaa ggaactggca agtaccagtt cgccagagac tttatgagca catcattctg     1200

gagacttgga gtagagtatg ctcgggctca gggaagcagc atcaatgagg atatggctgc     1260

cgagctaaag ctgaccccag cggcaaggag gggcctggca gctgctgccc aacgagcgtc     1320

cgaggagacc ggcagcatgg acattcccac tcaacaagct ggggtcctca cagggctcag     1380

cgacggaggc cctcaagccc cacaaggtgg actgaacagg tcgcaagggc aaccggacgc     1440

cggagatggg gagacccaat ttttagattt gatgagagca gtggcaaata gtatgagaga     1500

agcgccaaac tctgtgcaga acaccactca gcaggagcct ccatctactc ctgggccatc     1560

tcaagacaac gacaccgact ggggatactg accgacaaca ctcagcctgc ctccatcgaa     1620

ttatctcgat tcttctgcct gtaacctaac ccctggtcca cagtctcaca cggccaaacc     1680

cgcaaacgag cccccccctc tctccccccc cctccagcca cacggctcca accgcccaaa     1740

acaacacggg cacaactcga ctcactcata atctacacag agccgaagat cttagaaaaa     1800

aatacgggta gaagagagac attcagagat caggacaaat catcagggtc tccgctctcc     1860

cctctaccca gcagaccaga gtgaagatgg ccaccttcac ggatgcagag atcgacgatc     1920

tatttgaaac cagtggaact gtcattgaca gcataattac ggcccaaggc aacccagtag     1980

agactgttgg aaggagcgca atcccacaag gcaaaactaa agcattgagt gcagcatggg     2040

agaaacatgg aagcacccaa ccgccggccg gccaagacac ccctgatcga atggacagat     2100

cagacaaaca accatcccca cccgaacagg caaccacaca caacagcccg ccagccacat     2160

ccaccgacca gccccccacc caggccgcag gcgaagccgg tgacacacag ctcaagactg     2220

gagcaagcaa ctccctcctg tcgatgctcg acaagcttag caataaatcg tccaatgcta     2280

aaaagggccc acggtcgagt ccccaggaag ggcaccacca acctccgacc cagcagcaag     2340

ggagtcaaca gagccgcgga aacagtcagg agagatcgca aaaccaggtc aaggccgcct     2400

ctggagacca gggcacagac gcgaacacag catatcatgg acaatggaag gagtcacaac     2460

catcagctgg tgcaatccct catgctctcc ggtcagggca gagccaagcc aatactcctg     2520

catctgtgga tcatgtccag ctacctgtcg actttgtgca ggcgatgatg tctatgatgg     2580

aggcgatatc acagaaggta aataaagtcg actatcagct agaccttgtc tcaaagcaga     2640

catcctccat ccccatgatg cgatctgaaa tccaacagct gaaaacatcc gttgcggtca     2700

tggaagccaa cctgggcatg atgaagattc tggaccctgg ttgtgctaac gtttcatctt     2760

taagtgacct acgggcggtc gcccgctctc acccagtttt agtttcaggc cccggagacc     2820

catctcctta tgtgacacaa gggggtgaat tgatactcaa taaactctcg caaccagtgc     2880

aacatccttc tgagttgatt aaacctgcca cgataagcgg gcctgatata ggagtggaga     2940

aggacactgt ccgtgcattg atcacctcac gcccaatgca tccgagctct tcagctaagc     3000

tcctgagtaa gctggatgca gccgggtcga tagaagaaat taggaaaatc aaacgccttg     3060

cgctgaatgg ctgatcacta ctacaacccg caacgggttc ccgtttatct attgtcacaa     3120

ggaacccgcc ccgagccctc ctctataaac ccaagattca aggctccaag cgataacctt     3180

ctcccgcctc ttccatccca ctgaatgatc gcgcagctgc aattaatcta gcaacattaa     3240

agattaagaa aaaatacggg tagaatcgga gtgcaccgat tgtgccaaga tggactcatc     3300

taggacaatt gggttatact ttgattctgc ccttccttct agcaacctgt tagcattccc     3360

gattgtctta cgagatgtag gagatggaaa gaagcaaatt actccgcaat ataggatccg     3420

gcgtcttgac tcgtggacag acagtaaaga agactcggta ttcatcacta cctacggatt     3480

catcttccag gttgggaatg aagaagtcac tgtcggcatg atcaatgata atcccaagcg     3540

agagttactc tccgctgcga tgctctgcct aggaagcgtc ccgaatgttg gagatcctgt     3600

tgagctggca agggcctgcc tcactatggt ggtaacatgc aagaagagtg caactaatac     3660

tgagagaatg gtcttctcag tagtgcaggc accccgggtg ctgcaaagct gtagggtcgt     3720

ggcagacaaa tactcgtcag tgaatgcagt taagcacgtg aaagcaccag agaagatccc     3780

ttggagtgaa accctagagt acaaggtgaa ttttgtctct ttgactgtgg tgccgaagaa     3840

ggatgtctac aagatcccaa ccgcagtatt gaaggtatcc ggctcgagcc tgtataatct     3900

tgcgctcaat gtcactattg atgtggaggt agacccaaag agcccgttag tcaagtccct     3960

ttctaggtcc gacagtggat actatgctaa tctcttctta catatcggac ttatgtccac     4020

tgtagataag aggggaaaga aagtgacatt tgaccagctg gagaggaaga taaggagact     4080

tgatctatct gtcgggctca gtgatgtgct cggaccttct gtgcttgtga aggcgagagg     4140

tgcacggact aggctgctgg cacctttctt ctctaacagc gggacagcct gctaccctat     4200

agcaaatgcc tctcctcagg tagctaagat actctggagt cagaccgcgt gcctgcggag     4260

tgtaaaaatc attattcaag cgggcaccca acgcgctgtc gcagtgactg ctgaccatga     4320

ggttacctct actaagatag agaagaggca taccatcgct aaatacaatc ccttcaagaa     4380

ataggccgta tccctgagac tgcaattcac ccgccttccc aaaacaccat gacaccagat     4440

aatgatctgt cttgattact tacagttagt ttccctgtct atcaaattag aaaaaacacg     4500

ggtagaagag ttcggatccc ggccggcgca ccaaaagcgc aagatgggcc ccagatcttc     4560

taccaggatc ccagtacctc taatgctgac catacggatc acgctggcac tgagttatgt     4620

ccgtctgaca agttctcttg atggcaggcc tcttgcagcc gcagggatcg tggtaacagg     4680

ggataaagca gttaacatat acacctcatc ccagacaggg tcaatcatag tcaagttact     4740

cccaaatatg cccaaggaca aagaggcatg tgcaaaagcc ccattggagg cttacaacag     4800

gacactgact actttgctta ccccccttgg tgattctatc cgcaggatac aagagtctgt     4860

gactacatcc ggaggaagga gacagagacg ctttataggt gccattattg gcagtgtagc     4920

tctaggggtt gcaacagctg cacagataac ggcagcctcg gctctgatac aagccaacca     4980

gaatgctgct aacatcctcc ggcttaagga gagcattgct gcaaccaatg aagctgtaca     5040

cgaggtcact ggcggattgt cacagttagc agtggcagtt ggaaagatgc agcaatttgt     5100

taatgaccag tttaataaca cagctcaaga gttggactgt ataaaaatta cacagcaggt     5160

tggtgtagaa ctcaacttat acttaactga attgactaca gtgttcgggc cacaaatcac     5220

ttcccctgcc ttaactcagt tgactgttca ggctctttac aatctggctg gtggtaatgt     5280

agattacttg ttgactaagt taggtgtagg gaacaaccag ctcagctcat tgattggtag     5340

cggcttgatc accggtaacc ctatttttta cgactcacag actcaactct tgggcataca     5400

ggtgacttta ccctcagtcg ggaacctaaa taatatgcgt gccacctact tggagacctt     5460

gtctgtaagc acaacaaagg gatttgcctc agcacttgtc ccaaaagtag tgacacaggt     5520

cggttctgtg atagaagagc ttgacacctc atactgtata gaagctgatt tggatttata     5580

ttgtacaaga atagtgacat tccctatgtc ccctggtatt tattcctgtt tgagcggcaa     5640

tacatcggct tgcatgtatt caaggactga aggcgcactt actacaccat acatgactct     5700

caaaggctca gttgttgcca attgccagat gacaacatgt agatgtgcag accccccggg     5760

tatcatatca caaaattatg gagaggctgt gtctctaata gataagcact catgcaatgt     5820

cgtatcctta gacgggataa ctttgaggct cagtggggaa tttgatgcaa cttatcaaaa     5880

gaatatctca atattagatt ctcaagtact agtgacaggc aatctcgata tctcaactga     5940

gcttgggaat gtcaaccact caataagtaa tgctttggat aagttagagg aaagcaacag     6000

caaactagac aaagtcaatg tcaaactgac cagcacatct gctctcatta cctatattgt     6060

tttaactgtc atatctcttg ttcttggtat gcttagcctg gttctagcat gctatctgat     6120

gtacaagcaa aaagcgcaac gaaagacctt gttgtggctt ggaaataata ccctagatca     6180

gatgagagct actacaaaaa tgtgaatgca gatgagaggc agaggtatcc ccaatagcaa     6240

tctgtgtgtc aattctggca gcctgttaat cagaagaatt aagaaaaaac taccggatgt     6300

aggtgaacaa aagggaatat acgggtagaa cggcctgaga ggccacccct caatcgggag     6360

ccaggcccca ctacgtccgc tctaccgcat caccaacagc agtcttcagt catggacagc     6420

gcagttagcc aagttgcgct agagaatgat agaagagaag cgaataatac atggcgcttg     6480

gttttccgga tcgcagcctt acttttactg gtaataacct tagccgtctc tgcagtcgcc     6540

ctggcatata gtatggaggc tagcacacct ggcgaccttg taagcatacc gactgcgatc     6600

tctagggcag aggaaaggat tacatctgca ctcggttcca atcaagatgt agtagatagg     6660

atatacaagc aagtggccct tgagtctcca ttggcactgc taaataccga atctataatt     6720

atgaatgcaa taacgtctct ctcttatcaa atcaatggag ccacaaataa tagcgggtgt     6780

ggggcacctg ttcatgaccc agattacatc ggggggatag gtcaagaact tattgtagat     6840

gatacgagtg acgtcacatc attttatccc tctgcattcc aagaacacct gaattttatc     6900

ccggcgccca ctacaggatc aggctgcact cggataccct cattcgacat gagtgctacc     6960

cattactgtt acactcacaa tgtgatattg tctggctgca gagatcactc acactcacat     7020

cagtatttag cacttggtgt gcttcggaca tctgcaacag ggagggtatt cttttctact     7080

ctgcgttcca tcaacttgga tgacgcccaa aatcggaagt cttgcagtgt gagtgcaact     7140

cctttaggtt gtgatatgct gtgctctaaa atcacagaga ctgaggaaga ggattataaa     7200

tcagttatcc ccacatcgat ggtacatgga aggttagggc ttgacggcca ataccatgag     7260

aaggacctag acgtcacaac actatttagg gactgggtgg caaattaccc aggagtagga     7320

ggtgggtctt ttattaacaa tcgcgtatgg ttcccggtct acggagggct aaaacccagc     7380

tcgcctagtg acactgcaca agaagggaga tacgtaatat acaagcgata caatgacaca     7440

tgcccggatg agcaagatta ccagattcgg atggctaagt catcgtataa gcctaggcgg     7500

tttggtggaa aacgcgtaca gcaggccatc ctatccatca aggtgtcaac atccttgggt     7560

gaggacccgg tgttgactgt accgcctaat acggtcgcac tcatgggggc cgaaggcaga     7620

gttctcacag tggggacatc tcatttctta tatcagcgag ggtcatcata cttctctccc     7680

gctttgttat accctatgac agtcaacaac aaaacagcca ctcttcataa tccttataca     7740

ttcaatgctt tcactcggcc aggtagtgtc ccttgccagg cttcagcaag atgccccaac     7800

tcatgtgtta ccggagtcta tactgatcca tatcccttag tcttccatag gaaccacacc     7860

ttgcgagggg tattcggaac aatgcttgat gacgaacaag caagactcaa ccctgtatct     7920

gcagtatttg ataacatatc ccgcagtcgc ataactcggg taagttcaag cagtaccagg     7980

gcagcataca cgacatcaac gtgttttaaa gttgtcaaga ccaataaaac ctattgcctc     8040

agcattgcag aaatatccaa taccctcttc ggggaattca gaattgtccc cttactagtt     8100

gagattctca aggatggtgg ggtttaagaa gctaggaatg gtcggttgag tcaaccgtga     8160

gaaggcgggg aagatgatat tgcatcatct atcttctgta acaccaagaa tcaaatcgaa     8220

taccagtgcg agctcgaatc ctacgctgcc agtcagccat aatcggctgg tgctaatgtg     8280

gttagcctga atcttgtcga tagtcacttg attaagaaaa aatgtggacg gtagtgaaat     8340

ataaggcaaa gcagctcaca gaggacagca cgggtaggac atggcgggct ccggacccga     8400

aagggcagag catcagatta tcctaccaga gtcacatctg tcctcaccat tggtcaagca     8460

taaattgctt tattactgga aattaactgg gctaccgctt cctgacgaat gtgacttcga     8520

ccatcttatt atcagccgac aatggaagaa ggtacttgaa tcggccaccc ctgacattga     8580

gagaatgata aaactagggc gggcagtaca ccagactctc aaccacaatt ccaggataac     8640

cggagtactc catccccggt gtttagagga actggctagt attgaggttc ctgattcaac     8700

caacaaattt cggaagatcg aaaaaaagat ccagattcac aacacaaggt atggagaact     8760

gttcacaaga ttatgcacgc atgtagaaaa gaaactattg gggtcatctt ggtctaacaa     8820

tgtcccacgg tcagaggaat tcaacagcat ccgtacagat ccggcatttt ggtttcactc     8880

aaaatggtcc acagccaaat ttgcatggct ccatataaaa caggtccaga ggcatctgat     8940

tgtagcagca agaacaaggt ccgcagtcaa caaattagtg acgctgaccc ataaggtagg     9000

ccaaatcttt gttactcctg agcttgtcat tgtgacacat acagatgaga acaagttcac     9060

gtgtcttacc caggaacttg tgttgatgta tgcagatatg atggagggca gagatatggt     9120

cagcataata tcatccacgg cggcacatct taggagctta tcagagaaaa ttgatgatat     9180

tctgcggtta gtagatgctc tggcaagaga tttgggcaat caagtctacg atgttgtagc     9240

actaatggag ggattcgcat acggcgctgt tcagctgctt gaaccgtcag gtacatttgc     9300

gggggatttc ttcgcattca acctgcagga gctcaaagat actctaaccg gactcctccc     9360

caaggatatc gcagaatctg tgactcacgc aatcgcaacc atattctctg gcttagaaca     9420

aaatcaagca gctgagatgt tgtgcctgtt gcgtctgtgg ggtcacccac tactcgagtc     9480

ccgtattgca gcaaaagcag ttaggagtca aatgtgcgca ccaaaaatgg tagactttga     9540

tatgatcctc caggtattat ctttctttaa aggaacaatc atcaatggat atagaaagaa     9600

gaatgcaggc gtgtggccac gtgtcaagat agatacgata tacgggaagg tcatagggca     9660

gctacacgca gattctgcag agatttcaca tgatgtcatg ttgagggaat acaagagttt     9720

atctgcactt gaattcgagc catgtataga gtatgaccct gtcaccaatc tgagcatgtt     9780

tttaaaagac aaggcaatcg cacacccgaa agacaactgg ctcgcttcgt ttaggcgaaa     9840

ccttctctct gaggaccaga agaaacatgt aagagaggca acctcaacta accgcctctt     9900

gatagagttc ttagagtcaa atgattttga tccatataaa gagatggaat atctgacgac     9960

ccttgagtac ctaagagatg ataatgtggc agtatcatac tcactcaaag aaaaagaggt    10020

gaaagttaat gggcggattt tcgcaaagct aacaaataga ttaaggaatt gtcaggtaat    10080

ggcagaaggg atcctagctg accagattgc acctttcttc cagggaaatg gggtcattca    10140

ggatagcata tctttgacta aaagtatgct agcgatgagt caactgtctt tcaacagcaa    10200

caagaaacgt attactgact gcaaagaaag agtatcctca aaccgcaatc atgatccgaa    10260

gagcaagaat cgtcggagag ttgccacttt tgtaactacc gacctgcaaa agtattgtct    10320

caattggaga tatcagacag tcaagctgtt cgctcatgcc atcaatcagc tgatgggctt    10380

acctcacttc ttcgagtgga ttcatcttag actaatggat actacgatgt ttgtagggga    10440

ccctttcaat cctccaagtg accctacgga ctgtgatcta tcaagagtcc caaatgatga    10500

catatatatt gtcagtgcta ggggaggcat tgagggatta tgccagaagc tatggacaat    10560

gatctcaatt gctgcaatcc agcttgctgc agcaagatca cattgtcgcg ttgcctgtat    10620

ggtacaaggc gacaatcaag taatagctgt aacgagagag gtaagatcag atgactcccc    10680

agagatggtg ttaacacaat tgcatcaagc cagtgataat ttcttcaagg aattgattca    10740

tgtcaatcat ttgatcggcc ataatttgaa ggatcgtgaa accatcaggt cagacacgtt    10800

cttcatatac agcaaacgaa tattcaaaga tggagcaata ctcagtcagg tcctcaaaaa    10860

ctcatctaaa ttagtgctaa tatcaggcga ccttagtgaa aacactgtaa tgtcttgtgc    10920

caacattgca tctactgtag cacggttatg cgagaacggg cttcctaagg atttctgtta    10980

ttacttaaac tacttaatga gttgcgtgca gacatacttc gattccgaat tttccatcac    11040

caacaactcg caactcgatt ctaaccagtc gtggatagag gacatttctt ttgtgcactc    11100

atatgtcctg acccctgctc aactgggggg actgagtaac cttcaatact caaggctcta    11160

cacaaggaac atcggcgacc cgggaaccac tgctttcgca gagatcaaga gattagaggc    11220

agtggggtta ctgagtccta gcattatgac taacatctta actaggccgc ctggaaatgg    11280

agattgggcc agtctgtgca acgatccata ctcctttaat tttgagactg tcgcaagccc    11340

aaatattgtc cttaagaaac atacacaaag agtcctattt gaaacttgct cgaatccctt    11400

attatctgga gtgcacacag aggataatga ggcagaagag aaggcattgg ctgaattctt    11460

gctcaatcaa gaaatgattc atccacgtgt cgcgcatgct atcatggaag caagctctgt    11520

aggtaggaga aagcaaattc aggggcttgt tgacacaaca aacaccgtga ttaagattgc    11580

actgactagg aggccactcg gcatcaagag gctgatgcgg atagtcaatt actcgagcat    11640

gcatgcaatg ctatttagag atgatgtttt ctcgtctaat agatccaacc atcccttagt    11700

ctcttctgat atgtgttctc agacactggc agactatgca cggaacagaa gctggtcacc    11760

tttgacaggg ggtagaaaaa tactgggtgt atctaatcct gataccatag aacttgtaga    11820

gggtgagatc cttagtgtca gtggagggtg cactagatgt gacagtgggg atgaacagtt    11880

tacttggttc catcttccaa gcaatataga gctaaacgat gacaccagca agaatcctcc    11940

aatgagagtg ccatatctcg ggtcaaagac tcaagagagg agagccgcct cgcttgcgaa    12000

aatagctcat atgtcaccac acgtgaaggc ggctctaagg gcgtcatctg tgttaatctg    12060

ggcttatggg gacaacgaaa taaactggac tgctgccctt aagattgcaa ggtctcggtg    12120

caacataagc tcagagtatc ttcgactatt gtcacccttg cctacagctg ggaatctcca    12180

acatagattg gacgacggca taactcagat gacattcacc cctgcatctc tatacagggt    12240

gtcaccttac attcatatat ctaatgattc tcaaaggcta tttactgaag aaggagtcaa    12300

agaggggaat gtggtttatc agcaaatcat gctcttgggt ttgtccttaa ttgagtcact    12360

cttcccaatg acaacaacca agacatatga tgaaatcaca ttgcacctcc acagtaaatt    12420

tagctgctgt atcagggaag cacctgttgc agttcctttc gagctactcg gggtggcacc    12480

ggaactaagg gcagtaacct caaataagtt tatgtatgat cctagccctg tatcagaggg    12540

agactttgcg agacttgact tagctatctt taagagttat gaacttaatt tagagtcata    12600

ttccacaata gagctaatga acgttctttc aatatctagt gggaagttga ttggccagtc    12660

tgtggtttct tatgatgaag atacctccat aaagaatgac gctataatag tgtatgacaa    12720

cacacggaat tggatcagcg aagctcagaa ttcagatgtg gtccgcctat tcgagtatgc    12780

ggcactcgaa gtgctcctcg actgttctta tcaactctac tatctgagag taagaggcct    12840

aaacaatatc gtcctgtaca tgagtgattt atacaagaat atgccaggaa ttctactctc    12900

taatattgca gccacaatat ctcaccctgt catccattca aggttgaatg cagtaggtct    12960

ggtcaaccat gacgggtcac accaacttgc agacacagat ttcattgaaa tgtctgcaaa    13020

gctgctagtc ttttgcactc gacgcgtggt ctcaggttta catgcaggga ataagtatga    13080

cctgctgttt ccatctgtct tggatgataa cctaagtgag aagatgcttc agttgatatc    13140

ccaattatgc tgtctgtata cggtgctctt tgctacaaca agagaaatcc cgaaaataag    13200

aggcttatct gcagaagaga aatgttcagt acttactgag tacctactgt cagatgctgt    13260

gaaaccgtta cttgggtccg agcaagtgag ctctatcatg tctcccaaca tagttacgtt    13320

cccagccaat ctgtattaca tgtctaggaa gagccttaat ttgatcaggg agagagagga    13380

cagggatact atcttggcat tgttgttccc tcaagaaccg ctgctcgagt ttcctctggt    13440

acgagatatt ggtgctcgtg taaaagatcc atttacccga caacctgcgg cgtttttaca    13500

agagttagat ttgagtgctc cggcaaggta tgacgcattc acaatcagtc aggcgcattc    13560

tgaacacata ttgccaaacc cagaggaaga tcacttagta cgatacttgt tcagaggaat    13620

agggactgcg tcctcctctt ggtataaggc atcccatctt ctttctgtac ccgaggtcag    13680

atgtgcaagg catgggaact ccttatattt agcagaagga agtggagcca tcatgagtct    13740

tctcgaattg catataccac acgaaactat ctattacaat acacttttct cgaacgagat    13800

gaacccccca cagcgacatt tcggaccaac tccaacacag tttctgaatt cggttgtttt    13860

taggaattta caggcggaag taccatgcaa ggatggattt gtccaggagt tccgtccgtt    13920

atggagagag aatacagaag aaagcgatct gacctcagat aaagcagtgg gatatatcac    13980

atctgtagtg ccgtacaggt ctgtatcatt gctgcattgt gacattgaaa tccctccagg    14040

atctaatcaa agcttactag atcagctggc taccaatctg tctctgattg ccatgcattc    14100

tgtgaaggag ggcggggtcg tgattatcaa agtactgtat gcaatgggat attacttcca    14160

tctactcatg aacttgttta ctccatgttc cacgaaagga tatattctct ctaatggcta    14220

tgcctgtaga ggggatatgg agtgttacct gatatttgtc atgggctacc taggcgggcc    14280

tacatttgta catgaggtgg tgaggatggc aaaaacgcta gtacagcggc atggcacact    14340

tttgtctaag tcagatgaga ttacactgac taggttattt acttcacagc aacagcgtgt    14400

aacagacatc ctatccagcc ctttaccgag actaatgaag tacttgagag agaatattga    14460

tactgcactg attgaagccg ggggacagcc tgtccgtcca ttctgtgcag agagtttagt    14520

gagcacacta acagacatga ctcagacaac ccagatcatc gccagccaca ttgatacagt    14580

cattcgatct gtgatctata tggaagcaga gggtgatctt gctgacacag tattcttatt    14640

taccccttac aacctctcta tggacgggaa aaagagaaca tcacttaaac agtgcacaag    14700

acagatctta gaggtcacaa tactgggtct cagagtcaaa aatctcaata aagtaggtga    14760

tgtaatcagc ctagtactca gaggtatgat ttctctggag gaccttctcc cactgagaac    14820

ctacttgaag tgtagtacct gccctaagta tttgaaggct gtcctaggta ttaccaaact    14880

caaagaaatg ttcacagacg cctctttatt atacttgact cgtgctcaac aaaaattcta    14940

catgaaaact ataggcaatg cagtcaaggg atactatagt aactgtgact cttaaaggca    15000

accacatatc aataggccct ctttctagcc gatcgtattc ttgttgactt cattatacca    15060

tattagaaaa aaattgaatt ccgacccttt aagactcgta ttcggattca aataattatc    15120

tcagaaaaaa agtgcacgta gttgttcttg attatagtcc cgtcattcac caagtctttg    15180

tttggt                                                               15186




<210> 3
<211> 15198
<212> DNA
<213> Newcastle disease virus

<220> 
<223> Mut HN(F277L)/M(G165W)+ AfeI

<400> 3
accaaacaga gaatccgtga gatacgataa aaggcgaagg agcaatcgaa gtcgtacggg       60

tagaaggtgt gaatctcgag tgcgagaccg aagcttaaac tcgagagagc cttctgccaa      120

catgtcttcc gtatttgacg agtatgaaca gctcctcgcg gctcagactc gccctaatgg      180

agctcacgga ggaggagaga aggggagcac cttaaaagtt gaagtcccgg tattcactct      240

taacagtgac gacccagaag atagatggaa ctttgcagta ttctgtctta ggattgctgt      300

tagcgaagat gccaacaaac cactcagaca aggtgctctc atatctctct tatgctccca      360

ttctcaagtg atgaggaacc atgtcgccct tgcagggaaa cagaatgagg ccacactggc      420

tgttcttgag atcgatggtt tcaccaacag cgtgcctcaa tttaacaaca ggagtggagt      480

gtctgaggag agagcacaga gattcttgat gatagcaggg tccctccctc gggcatgcag      540

caacggtacc ccgttcatca cagctggggt tgaagatgat gcaccagaag acatcactga      600

tactctggaa agaatcatct ctatccaggc tcaagtatgg gtcacggtag caaaggccat      660

gactgcatat gagacagcgg atgagtcgga aacaagaaga atcaataagt atatgcagca      720

aggcagagtc caaaagaagt acatcctcca ccccgtatgt aggagcgcaa ttcaactcac      780

gattagacaa tctctggcag tccgcatttt cttggttagc gagcttaaga gaggccgcaa      840

cacggcaggt ggaagttcca cttattatag cttggtaggg gacatagact catacatcag      900

gaacaccggg cttactgcat tcttcctgac actcaggtat ggaattaaca ccaagacatc      960

agcccttgca ctcagcagcc tcgcaggcga tatccaaaaa atgaagcagc tcatgcgtct     1020

atatcggatg aaaggagata atgcgccgta catgacactg ctcggtgaca gtgaccagat     1080

gagctttgca ccggctgagt atgcacaact ctactctttt gcaatgggta tggcatccgt     1140

cctagacaaa ggaactggca agtaccagtt cgccagagac tttatgagca catcattctg     1200

gagacttgga gtagagtatg ctcgggctca gggaagcagc atcaatgagg atatggctgc     1260

cgagctaaag ctgaccccag cggcaaggag gggcctggca gctgctgccc aacgagcgtc     1320

cgaggagacc ggcagcatgg acattcccac tcaacaagct ggggtcctca cagggctcag     1380

cgacggaggc cctcaagccc cacaaggtgg actgaacagg tcgcaagggc aaccggacgc     1440

cggagatggg gagacccaat ttttagattt gatgagagca gtggcaaata gtatgagaga     1500

agcgccaaac tctgtgcaga acaccactca gcaggagcct ccatctactc ctgggccatc     1560

tcaagacaac gacaccgact ggggatactg accgacaaca ctcagcctgc ctccatcgaa     1620

ttatctcgat tcttctgcct gtaacctaac ccctggtcca cagtctcaca cggccaaacc     1680

cgcaaacgag cccccccctc tctccccccc cctccagcca cacggctcca accgcccaaa     1740

acaacacggg cacaactcga ctcactcata atctacacag agccgaagat cttagaaaaa     1800

aatacgggta gaagagagac attcagagat caggacaaat catcagggtc tccgctctcc     1860

cctctaccca gcagaccaga gtgaagatgg ccaccttcac ggatgcagag atcgacgatc     1920

tatttgaaac cagtggaact gtcattgaca gcataattac ggcccaaggc aacccagtag     1980

agactgttgg aaggagcgca atcccacaag gcaaaactaa agcattgagt gcagcatggg     2040

agaaacatgg aagcacccaa ccgccggccg gccaagacac ccctgatcga atggacagat     2100

cagacaaaca accatcccca cccgaacagg caaccacaca caacagcccg ccagccacat     2160

ccaccgacca gccccccacc caggccgcag gcgaagccgg tgacacacag ctcaagactg     2220

gagcaagcaa ctccctcctg tcgatgctcg acaagcttag caataaatcg tccaatgcta     2280

aaaagggccc acggtcgagt ccccaggaag ggcaccacca acctccgacc cagcagcaag     2340

ggagtcaaca gagccgcgga aacagtcagg agagatcgca aaaccaggtc aaggccgcct     2400

ctggagacca gggcacagac gcgaacacag catatcatgg acaatggaag gagtcacaac     2460

catcagctgg tgcaatccct catgctctcc ggtcagggca gagccaagcc aatactcctg     2520

catctgtgga tcatgtccag ctacctgtcg actttgtgca ggcgatgatg tctatgatgg     2580

aggcgatatc acagaaggta aataaagtcg actatcagct agaccttgtc tcaaagcaga     2640

catcctccat ccccatgatg cgatctgaaa tccaacagct gaaaacatcc gttgcggtca     2700

tggaagccaa cctgggcatg atgaagattc tggaccctgg ttgtgctaac gtttcatctt     2760

taagtgacct acgggcggtc gcccgctctc acccagtttt agtttcaggc cccggagacc     2820

catctcctta tgtgacacaa gggggtgaat tgatactcaa taaactctcg caaccagtgc     2880

aacatccttc tgagttgatt aaacctgcca cgataagcgg gcctgatata ggagtggaga     2940

aggacactgt ccgtgcattg atcacctcac gcccaatgca tccgagctct tcagctaagc     3000

tcctgagtaa gctggatgca gccgggtcga tagaagaaat taggaaaatc aaacgccttg     3060

cgctgaatgg ctgatcacta ctacaacccg caacgggttc ccgtttatct attgtcacaa     3120

ggaacccgcc ccgaagcgct gaccgagccc tcctctataa acccaagatt caaggctcca     3180

agcgataacc ttctcccgcc tcttccatcc cactgaatga tcgcgcagct gcaattaatc     3240

tagcaacatt aaagattaag aaaaaatacg ggtagaatcg gagtgcaccg attgtgccaa     3300

gatggactca tctaggacaa ttgggttata ctttgattct gcccttcctt ctagcaacct     3360

gttagcattc ccgattgtct tacgagatgt aggagatgga aagaagcaaa ttactccgca     3420

atataggatc cggcgtcttg actcgtggac agacagtaaa gaagactcgg tattcatcac     3480

tacctacgga ttcatcttcc aggttgggaa tgaagaagtc actgtcggca tgatcaatga     3540

taatcccaag cgagagttac tctccgctgc gatgctctgc ctaggaagcg tcccgaatgt     3600

tggagatcct gttgagctgg caagggcctg cctcactatg gtggtaacat gcaagaagag     3660

tgcaactaat actgagagaa tggtcttctc agtagtgcag gcaccccggg tgctgcaaag     3720

ctgtagggtc gtggcagaca aatactcgtc agtgaatgca gttaagcacg tgaaagcacc     3780

agagaagatc ccttggagtg aaaccctaga gtacaaggtg aattttgtct ctttgactgt     3840

ggtgccgaag aaggatgtct acaagatccc aaccgcagta ttgaaggtat ccggctcgag     3900

cctgtataat cttgcgctca atgtcactat tgatgtggag gtagacccaa agagcccgtt     3960

agtcaagtcc ctttctaggt ccgacagtgg atactatgct aatctcttct tacatatcgg     4020

acttatgtcc actgtagata agaggggaaa gaaagtgaca tttgaccagc tggagaggaa     4080

gataaggaga cttgatctat ctgtcgggct cagtgatgtg ctcggacctt ctgtgcttgt     4140

gaaggcgaga ggtgcacgga ctaggctgct ggcacctttc ttctctaaca gcgggacagc     4200

ctgctaccct atagcaaatg cctctcctca ggtagctaag atactctgga gtcagaccgc     4260

gtgcctgcgg agtgtaaaaa tcattattca agcgggcacc caacgcgctg tcgcagtgac     4320

tgctgaccat gaggttacct ctactaagat agagaagagg cataccatcg ctaaatacaa     4380

tcccttcaag aaataggccg tatccctgag actgcaattc acccgccttc ccaaaacacc     4440

atgacaccag ataatgatct gtcttgatta cttacagtta gtttccctgt ctatcaaatt     4500

agaaaaaaca cgggtagaag agttcggatc ccggccggcg caccaaaagc gcaagatggg     4560

ccccagatct tctaccagga tcccagtacc tctaatgctg accatacgga tcacgctggc     4620

actgagttat gtccgtctga caagttctct tgatggcagg cctcttgcag ccgcagggat     4680

cgtggtaaca ggggataaag cagttaacat atacacctca tcccagacag ggtcaatcat     4740

agtcaagtta ctcccaaata tgcccaagga caaagaggca tgtgcaaaag ccccattgga     4800

ggcttacaac aggacactga ctactttgct tacccccctt ggtgattcta tccgcaggat     4860

acaagagtct gtgactacat ccggaggaag gagacagaga cgctttatag gtgccattat     4920

tggcagtgta gctctagggg ttgcaacagc tgcacagata acggcagcct cggctctgat     4980

acaagccaac cagaatgctg ctaacatcct ccggcttaag gagagcattg ctgcaaccaa     5040

tgaagctgta cacgaggtca ctggcggatt gtcacagtta gcagtggcag ttggaaagat     5100

gcagcaattt gttaatgacc agtttaataa cacagctcaa gagttggact gtataaaaat     5160

tacacagcag gttggtgtag aactcaactt atacttaact gaattgacta cagtgttcgg     5220

gccacaaatc acttcccctg ccttaactca gttgactgtt caggctcttt acaatctggc     5280

tggtggtaat gtagattact tgttgactaa gttaggtgta gggaacaacc agctcagctc     5340

attgattggt agcggcttga tcaccggtaa ccctattttt tacgactcac agactcaact     5400

cttgggcata caggtgactt taccctcagt cgggaaccta aataatatgc gtgccaccta     5460

cttggagacc ttgtctgtaa gcacaacaaa gggatttgcc tcagcacttg tcccaaaagt     5520

agtgacacag gtcggttctg tgatagaaga gcttgacacc tcatactgta tagaagctga     5580

tttggattta tattgtacaa gaatagtgac attccctatg tcccctggta tttattcctg     5640

tttgagcggc aatacatcgg cttgcatgta ttcaaggact gaaggcgcac ttactacacc     5700

atacatgact ctcaaaggct cagttgttgc caattgccag atgacaacat gtagatgtgc     5760

agaccccccg ggtatcatat cacaaaatta tggagaggct gtgtctctaa tagataagca     5820

ctcatgcaat gtcgtatcct tagacgggat aactttgagg ctcagtgggg aatttgatgc     5880

aacttatcaa aagaatatct caatattaga ttctcaagta ctagtgacag gcaatctcga     5940

tatctcaact gagcttggga atgtcaacca ctcaataagt aatgctttgg ataagttaga     6000

ggaaagcaac agcaaactag acaaagtcaa tgtcaaactg accagcacat ctgctctcat     6060

tacctatatt gttttaactg tcatatctct tgttcttggt atgcttagcc tggttctagc     6120

atgctatctg atgtacaagc aaaaagcgca acgaaagacc ttgttgtggc ttggaaataa     6180

taccctagat cagatgagag ctactacaaa aatgtgaatg cagatgagag gcagaggtat     6240

ccccaatagc aatctgtgtg tcaattctgg cagcctgtta atcagaagaa ttaagaaaaa     6300

actaccggat gtaggtgaac aaaagggaat atacgggtag aacggcctga gaggccaccc     6360

ctcaatcggg agccaggccc cactacgtcc gctctaccgc atcaccaaca gcagtcttca     6420

gtcatggaca gcgcagttag ccaagttgcg ctagagaatg atagaagaga agcgaataat     6480

acatggcgct tggttttccg gatcgcagcc ttacttttac tggtaataac cttagccgtc     6540

tctgcagtcg ccctggcata tagtatggag gctagcacac ctggcgacct tgtaagcata     6600

ccgactgcga tctctagggc agaggaaagg attacatctg cactcggttc caatcaagat     6660

gtagtagata ggatatacaa gcaagtggcc cttgagtctc cattggcact gctaaatacc     6720

gaatctataa ttatgaatgc aataacgtct ctctcttatc aaatcaatgg agccacaaat     6780

aatagcgggt gtggggcacc tgttcatgac ccagattaca tcggggggat aggtcaagaa     6840

cttattgtag atgatacgag tgacgtcaca tcattttatc cctctgcatt ccaagaacac     6900

ctgaatttta tcccggcgcc cactacagga tcaggctgca ctcggatacc ctcattcgac     6960

atgagtgcta cccattactg ttacactcac aatgtgatat tgtctggctg cagagatcac     7020

tcacactcac atcagtattt agcacttggt gtgcttcgga catctgcaac agggagggta     7080

ttcttttcta ctctgcgttc catcaacttg gatgacgccc aaaatcggaa gtcttgcagt     7140

gtgagtgcaa ctcctttagg ttgtgatatg ctgtgctcta aaatcacaga gactgaggaa     7200

gaggattata aatcagttat ccccacatcg atggtacatg gaaggttagg gcttgacggc     7260

caataccatg agaaggacct agacgtcaca acactattta gggactgggt ggcaaattac     7320

ccaggagtag gaggtgggtc ttttattaac aatcgcgtat ggttcccggt ctacggaggg     7380

ctaaaaccca gctcgcctag tgacactgca caagaaggga gatacgtaat atacaagcga     7440

tacaatgaca catgcccgga tgagcaagat taccagattc ggatggctaa gtcatcgtat     7500

aagcctaggc ggtttggtgg aaaacgcgta cagcaggcca tcctatccat caaggtgtca     7560

acatccttgg gtgaggaccc ggtgttgact gtaccgccta atacggtcgc actcatgggg     7620

gccgaaggca gagttctcac agtggggaca tctcatttct tatatcagcg agggtcatca     7680

tacttctctc ccgctttgtt ataccctatg acagtcaaca acaaaacagc cactcttcat     7740

aatccttata cattcaatgc tttcactcgg ccaggtagtg tcccttgcca ggcttcagca     7800

agatgcccca actcatgtgt taccggagtc tatactgatc catatccctt agtcttccat     7860

aggaaccaca ccttgcgagg ggtattcgga acaatgcttg atgacgaaca agcaagactc     7920

aaccctgtat ctgcagtatt tgataacata tcccgcagtc gcataactcg ggtaagttca     7980

agcagtacca gggcagcata cacgacatca acgtgtttta aagttgtcaa gaccaataaa     8040

acctattgcc tcagcattgc agaaatatcc aataccctct tcggggaatt cagaattgtc     8100

cccttactag ttgagattct caaggatggt ggggtttaag aagctaggaa tggtcggttg     8160

agtcaaccgt gagaaggcgg ggaagatgat attgcatcat ctatcttctg taacaccaag     8220

aatcaaatcg aataccagtg cgagctcgaa tcctacgctg ccagtcagcc ataatcggct     8280

ggtgctaatg tggttagcct gaatcttgtc gatagtcact tgattaagaa aaaatgtgga     8340

cggtagtgaa atataaggca aagcagctca cagaggacag cacgggtagg acatggcggg     8400

ctccggaccc gaaagggcag agcatcagat tatcctacca gagtcacatc tgtcctcacc     8460

attggtcaag cataaattgc tttattactg gaaattaact gggctaccgc ttcctgacga     8520

atgtgacttc gaccatctta ttatcagccg acaatggaag aaggtacttg aatcggccac     8580

ccctgacatt gagagaatga taaaactagg gcgggcagta caccagactc tcaaccacaa     8640

ttccaggata accggagtac tccatccccg gtgtttagag gaactggcta gtattgaggt     8700

tcctgattca accaacaaat ttcggaagat cgaaaaaaag atccagattc acaacacaag     8760

gtatggagaa ctgttcacaa gattatgcac gcatgtagaa aagaaactat tggggtcatc     8820

ttggtctaac aatgtcccac ggtcagagga attcaacagc atccgtacag atccggcatt     8880

ttggtttcac tcaaaatggt ccacagccaa atttgcatgg ctccatataa aacaggtcca     8940

gaggcatctg attgtagcag caagaacaag gtccgcagtc aacaaattag tgacgctgac     9000

ccataaggta ggccaaatct ttgttactcc tgagcttgtc attgtgacac atacagatga     9060

gaacaagttc acgtgtctta cccaggaact tgtgttgatg tatgcagata tgatggaggg     9120

cagagatatg gtcagcataa tatcatccac ggcggcacat cttaggagct tatcagagaa     9180

aattgatgat attctgcggt tagtagatgc tctggcaaga gatttgggca atcaagtcta     9240

cgatgttgta gcactaatgg agggattcgc atacggcgct gttcagctgc ttgaaccgtc     9300

aggtacattt gcgggggatt tcttcgcatt caacctgcag gagctcaaag atactctaac     9360

cggactcctc cccaaggata tcgcagaatc tgtgactcac gcaatcgcaa ccatattctc     9420

tggcttagaa caaaatcaag cagctgagat gttgtgcctg ttgcgtctgt ggggtcaccc     9480

actactcgag tcccgtattg cagcaaaagc agttaggagt caaatgtgcg caccaaaaat     9540

ggtagacttt gatatgatcc tccaggtatt atctttcttt aaaggaacaa tcatcaatgg     9600

atatagaaag aagaatgcag gcgtgtggcc acgtgtcaag atagatacga tatacgggaa     9660

ggtcataggg cagctacacg cagattctgc agagatttca catgatgtca tgttgaggga     9720

atacaagagt ttatctgcac ttgaattcga gccatgtata gagtatgacc ctgtcaccaa     9780

tctgagcatg tttttaaaag acaaggcaat cgcacacccg aaagacaact ggctcgcttc     9840

gtttaggcga aaccttctct ctgaggacca gaagaaacat gtaagagagg caacctcaac     9900

taaccgcctc ttgatagagt tcttagagtc aaatgatttt gatccatata aagagatgga     9960

atatctgacg acccttgagt acctaagaga tgataatgtg gcagtatcat actcactcaa    10020

agaaaaagag gtgaaagtta atgggcggat tttcgcaaag ctaacaaata gattaaggaa    10080

ttgtcaggta atggcagaag ggatcctagc tgaccagatt gcacctttct tccagggaaa    10140

tggggtcatt caggatagca tatctttgac taaaagtatg ctagcgatga gtcaactgtc    10200

tttcaacagc aacaagaaac gtattactga ctgcaaagaa agagtatcct caaaccgcaa    10260

tcatgatccg aagagcaaga atcgtcggag agttgccact tttgtaacta ccgacctgca    10320

aaagtattgt ctcaattgga gatatcagac agtcaagctg ttcgctcatg ccatcaatca    10380

gctgatgggc ttacctcact tcttcgagtg gattcatctt agactaatgg atactacgat    10440

gtttgtaggg gaccctttca atcctccaag tgaccctacg gactgtgatc tatcaagagt    10500

cccaaatgat gacatatata ttgtcagtgc taggggaggc attgagggat tatgccagaa    10560

gctatggaca atgatctcaa ttgctgcaat ccagcttgct gcagcaagat cacattgtcg    10620

cgttgcctgt atggtacaag gcgacaatca agtaatagct gtaacgagag aggtaagatc    10680

agatgactcc ccagagatgg tgttaacaca attgcatcaa gccagtgata atttcttcaa    10740

ggaattgatt catgtcaatc atttgatcgg ccataatttg aaggatcgtg aaaccatcag    10800

gtcagacacg ttcttcatat acagcaaacg aatattcaaa gatggagcaa tactcagtca    10860

ggtcctcaaa aactcatcta aattagtgct aatatcaggc gaccttagtg aaaacactgt    10920

aatgtcttgt gccaacattg catctactgt agcacggtta tgcgagaacg ggcttcctaa    10980

ggatttctgt tattacttaa actacttaat gagttgcgtg cagacatact tcgattccga    11040

attttccatc accaacaact cgcaactcga ttctaaccag tcgtggatag aggacatttc    11100

ttttgtgcac tcatatgtcc tgacccctgc tcaactgggg ggactgagta accttcaata    11160

ctcaaggctc tacacaagga acatcggcga cccgggaacc actgctttcg cagagatcaa    11220

gagattagag gcagtggggt tactgagtcc tagcattatg actaacatct taactaggcc    11280

gcctggaaat ggagattggg ccagtctgtg caacgatcca tactccttta attttgagac    11340

tgtcgcaagc ccaaatattg tccttaagaa acatacacaa agagtcctat ttgaaacttg    11400

ctcgaatccc ttattatctg gagtgcacac agaggataat gaggcagaag agaaggcatt    11460

ggctgaattc ttgctcaatc aagaaatgat tcatccacgt gtcgcgcatg ctatcatgga    11520

agcaagctct gtaggtagga gaaagcaaat tcaggggctt gttgacacaa caaacaccgt    11580

gattaagatt gcactgacta ggaggccact cggcatcaag aggctgatgc ggatagtcaa    11640

ttactcgagc atgcatgcaa tgctatttag agatgatgtt ttctcgtcta atagatccaa    11700

ccatccctta gtctcttctg atatgtgttc tcagacactg gcagactatg cacggaacag    11760

aagctggtca cctttgacag ggggtagaaa aatactgggt gtatctaatc ctgataccat    11820

agaacttgta gagggtgaga tccttagtgt cagtggaggg tgcactagat gtgacagtgg    11880

ggatgaacag tttacttggt tccatcttcc aagcaatata gagctaaacg atgacaccag    11940

caagaatcct ccaatgagag tgccatatct cgggtcaaag actcaagaga ggagagccgc    12000

ctcgcttgcg aaaatagctc atatgtcacc acacgtgaag gcggctctaa gggcgtcatc    12060

tgtgttaatc tgggcttatg gggacaacga aataaactgg actgctgccc ttaagattgc    12120

aaggtctcgg tgcaacataa gctcagagta tcttcgacta ttgtcaccct tgcctacagc    12180

tgggaatctc caacatagat tggacgacgg cataactcag atgacattca cccctgcatc    12240

tctatacagg gtgtcacctt acattcatat atctaatgat tctcaaaggc tatttactga    12300

agaaggagtc aaagagggga atgtggttta tcagcaaatc atgctcttgg gtttgtcctt    12360

aattgagtca ctcttcccaa tgacaacaac caagacatat gatgaaatca cattgcacct    12420

ccacagtaaa tttagctgct gtatcaggga agcacctgtt gcagttcctt tcgagctact    12480

cggggtggca ccggaactaa gggcagtaac ctcaaataag tttatgtatg atcctagccc    12540

tgtatcagag ggagactttg cgagacttga cttagctatc tttaagagtt atgaacttaa    12600

tttagagtca tattccacaa tagagctaat gaacgttctt tcaatatcta gtgggaagtt    12660

gattggccag tctgtggttt cttatgatga agatacctcc ataaagaatg acgctataat    12720

agtgtatgac aacacacgga attggatcag cgaagctcag aattcagatg tggtccgcct    12780

attcgagtat gcggcactcg aagtgctcct cgactgttct tatcaactct actatctgag    12840

agtaagaggc ctaaacaata tcgtcctgta catgagtgat ttatacaaga atatgccagg    12900

aattctactc tctaatattg cagccacaat atctcaccct gtcatccatt caaggttgaa    12960

tgcagtaggt ctggtcaacc atgacgggtc acaccaactt gcagacacag atttcattga    13020

aatgtctgca aagctgctag tcttttgcac tcgacgcgtg gtctcaggtt tacatgcagg    13080

gaataagtat gacctgctgt ttccatctgt cttggatgat aacctaagtg agaagatgct    13140

tcagttgata tcccaattat gctgtctgta tacggtgctc tttgctacaa caagagaaat    13200

cccgaaaata agaggcttat ctgcagaaga gaaatgttca gtacttactg agtacctact    13260

gtcagatgct gtgaaaccgt tacttgggtc cgagcaagtg agctctatca tgtctcccaa    13320

catagttacg ttcccagcca atctgtatta catgtctagg aagagcctta atttgatcag    13380

ggagagagag gacagggata ctatcttggc attgttgttc cctcaagaac cgctgctcga    13440

gtttcctctg gtacgagata ttggtgctcg tgtaaaagat ccatttaccc gacaacctgc    13500

ggcgttttta caagagttag atttgagtgc tccggcaagg tatgacgcat tcacaatcag    13560

tcaggcgcat tctgaacaca tattgccaaa cccagaggaa gatcacttag tacgatactt    13620

gttcagagga atagggactg cgtcctcctc ttggtataag gcatcccatc ttctttctgt    13680

acccgaggtc agatgtgcaa ggcatgggaa ctccttatat ttagcagaag gaagtggagc    13740

catcatgagt cttctcgaat tgcatatacc acacgaaact atctattaca atacactttt    13800

ctcgaacgag atgaaccccc cacagcgaca tttcggacca actccaacac agtttctgaa    13860

ttcggttgtt tttaggaatt tacaggcgga agtaccatgc aaggatggat ttgtccagga    13920

gttccgtccg ttatggagag agaatacaga agaaagcgat ctgacctcag ataaagcagt    13980

gggatatatc acatctgtag tgccgtacag gtctgtatca ttgctgcatt gtgacattga    14040

aatccctcca ggatctaatc aaagcttact agatcagctg gctaccaatc tgtctctgat    14100

tgccatgcat tctgtgaagg agggcggggt cgtgattatc aaagtactgt atgcaatggg    14160

atattacttc catctactca tgaacttgtt tactccatgt tccacgaaag gatatattct    14220

ctctaatggc tatgcctgta gaggggatat ggagtgttac ctgatatttg tcatgggcta    14280

cctaggcggg cctacatttg tacatgaggt ggtgaggatg gcaaaaacgc tagtacagcg    14340

gcatggcaca cttttgtcta agtcagatga gattacactg actaggttat ttacttcaca    14400

gcaacagcgt gtaacagaca tcctatccag ccctttaccg agactaatga agtacttgag    14460

agagaatatt gatactgcac tgattgaagc cgggggacag cctgtccgtc cattctgtgc    14520

agagagttta gtgagcacac taacagacat gactcagaca acccagatca tcgccagcca    14580

cattgataca gtcattcgat ctgtgatcta tatggaagca gagggtgatc ttgctgacac    14640

agtattctta tttacccctt acaacctctc tatggacggg aaaaagagaa catcacttaa    14700

acagtgcaca agacagatct tagaggtcac aatactgggt ctcagagtca aaaatctcaa    14760

taaagtaggt gatgtaatca gcctagtact cagaggtatg atttctctgg aggaccttct    14820

cccactgaga acctacttga agtgtagtac ctgccctaag tatttgaagg ctgtcctagg    14880

tattaccaaa ctcaaagaaa tgttcacaga cgcctcttta ttatacttga ctcgtgctca    14940

acaaaaattc tacatgaaaa ctataggcaa tgcagtcaag ggatactata gtaactgtga    15000

ctcttaaagg caaccacata tcaataggcc ctctttctag ccgatcgtat tcttgttgac    15060

ttcattatac catattagaa aaaaattgaa ttccgaccct ttaagactcg tattcggatt    15120

caaataatta tctcagaaaa aaagtgcacg tagttgttct tgattatagt cccgtcattc    15180

accaagtctt tgtttggt                                                  15198




<210> 4
<211> 15186
<212> DNA
<213> Newcastle disease virus


<220> 
<223> Mut HN
      (F277L)/M(G165W)/F(F117S)/F(F190L)/L(V757I)/L(F1551S)/L(R1700L)

<400> 4
accaaacaga gaatccgtga gatacgataa aaggcgaagg agcaatcgaa gtcgtacggg       60

tagaaggtgt gaatctcgag tgcgagaccg aagcttaaac tcgagagagc cttctgccaa      120

catgtcttcc gtatttgacg agtatgaaca gctcctcgcg gctcagactc gccctaatgg      180

agctcacgga ggaggagaga aggggagcac cttaaaagtt gaagtcccgg tattcactct      240

taacagtgac gacccagaag atagatggaa ctttgcagta ttctgtctta ggattgctgt      300

tagcgaagat gccaacaaac cactcagaca aggtgctctc atatctctct tatgctccca      360

ttctcaagtg atgaggaacc atgtcgccct tgcagggaaa cagaatgagg ccacactggc      420

tgttcttgag atcgatggtt tcaccaacag cgtgcctcaa tttaacaaca ggagtggagt      480

gtctgaggag agagcacaga gattcttgat gatagcaggg tccctccctc gggcatgcag      540

caacggtacc ccgttcatca cagctggggt tgaagatgat gcaccagaag acatcactga      600

tactctggaa agaatcatct ctatccaggc tcaagtatgg gtcacggtag caaaggccat      660

gactgcatat gagacagcgg atgagtcgga aacaagaaga atcaataagt atatgcagca      720

aggcagagtc caaaagaagt acatcctcca ccccgtatgt aggagcgcaa ttcaactcac      780

gattagacaa tctctggcag tccgcatttt cttggttagc gagcttaaga gaggccgcaa      840

cacggcaggt ggaagttcca cttattatag cttggtaggg gacatagact catacatcag      900

gaacaccggg cttactgcat tcttcctgac actcaggtat ggaattaaca ccaagacatc      960

agcccttgca ctcagcagcc tcgcaggcga tatccaaaaa atgaagcagc tcatgcgtct     1020

atatcggatg aaaggagata atgcgccgta catgacactg ctcggtgaca gtgaccagat     1080

gagctttgca ccggctgagt atgcacaact ctactctttt gcaatgggta tggcatccgt     1140

cctagacaaa ggaactggca agtaccagtt cgccagagac tttatgagca catcattctg     1200

gagacttgga gtagagtatg ctcgggctca gggaagcagc atcaatgagg atatggctgc     1260

cgagctaaag ctgaccccag cggcaaggag gggcctggca gctgctgccc aacgagcgtc     1320

cgaggagacc ggcagcatgg acattcccac tcaacaagct ggggtcctca cagggctcag     1380

cgacggaggc cctcaagccc cacaaggtgg actgaacagg tcgcaagggc aaccggacgc     1440

cggagatggg gagacccaat ttttagattt gatgagagca gtggcaaata gtatgagaga     1500

agcgccaaac tctgtgcaga acaccactca gcaggagcct ccatctactc ctgggccatc     1560

tcaagacaac gacaccgact ggggatactg accgacaaca ctcagcctgc ctccatcgaa     1620

ttatctcgat tcttctgcct gtaacctaac ccctggtcca cagtctcaca cggccaaacc     1680

cgcaaacgag cccccccctc tctccccccc cctccagcca cacggctcca accgcccaaa     1740

acaacacggg cacaactcga ctcactcata atctacacag agccgaagat cttagaaaaa     1800

aatacgggta gaagagagac attcagagat caggacaaat catcagggtc tccgctctcc     1860

cctctaccca gcagaccaga gtgaagatgg ccaccttcac ggatgcagag atcgacgatc     1920

tatttgaaac cagtggaact gtcattgaca gcataattac ggcccaaggc aacccagtag     1980

agactgttgg aaggagcgca atcccacaag gcaaaactaa agcattgagt gcagcatggg     2040

agaaacatgg aagcacccaa ccgccggccg gccaagacac ccctgatcga atggacagat     2100

cagacaaaca accatcccca cccgaacagg caaccacaca caacagcccg ccagccacat     2160

ccaccgacca gccccccacc caggccgcag gcgaagccgg tgacacacag ctcaagactg     2220

gagcaagcaa ctccctcctg tcgatgctcg acaagcttag caataaatcg tccaatgcta     2280

aaaagggccc acggtcgagt ccccaggaag ggcaccacca acctccgacc cagcagcaag     2340

ggagtcaaca gagccgcgga aacagtcagg agagatcgca aaaccaggtc aaggccgcct     2400

ctggagacca gggcacagac gcgaacacag catatcatgg acaatggaag gagtcacaac     2460

catcagctgg tgcaatccct catgctctcc ggtcagggca gagccaagcc aatactcctg     2520

catctgtgga tcatgtccag ctacctgtcg actttgtgca ggcgatgatg tctatgatgg     2580

aggcgatatc acagaaggta aataaagtcg actatcagct agaccttgtc tcaaagcaga     2640

catcctccat ccccatgatg cgatctgaaa tccaacagct gaaaacatcc gttgcggtca     2700

tggaagccaa cctgggcatg atgaagattc tggaccctgg ttgtgctaac gtttcatctt     2760

taagtgacct acgggcggtc gcccgctctc acccagtttt agtttcaggc cccggagacc     2820

catctcctta tgtgacacaa gggggtgaat tgatactcaa taaactctcg caaccagtgc     2880

aacatccttc tgagttgatt aaacctgcca cgataagcgg gcctgatata ggagtggaga     2940

aggacactgt ccgtgcattg atcacctcac gcccaatgca tccgagctct tcagctaagc     3000

tcctgagtaa gctggatgca gccgggtcga tagaagaaat taggaaaatc aaacgccttg     3060

cgctgaatgg ctgatcacta ctacaacccg caacgggttc ccgtttatct attgtcacaa     3120

ggaacccgcc ccgagccctc ctctataaac ccaagattca aggctccaag cgataacctt     3180

ctcccgcctc ttccatccca ctgaatgatc gcgcagctgc aattaatcta gcaacattaa     3240

agattaagaa aaaatacggg tagaatcgga gtgcaccgat tgtgccaaga tggactcatc     3300

taggacaatt gggttatact ttgattctgc ccttccttct agcaacctgt tagcattccc     3360

gattgtctta cgagatgtag gagatggaaa gaagcaaatt actccgcaat ataggatccg     3420

gcgtcttgac tcgtggacag acagtaaaga agactcggta ttcatcacta cctacggatt     3480

catcttccag gttgggaatg aagaagtcac tgtcggcatg atcaatgata atcccaagcg     3540

agagttactc tccgctgcga tgctctgcct aggaagcgtc ccgaatgttg gagatcctgt     3600

tgagctggca agggcctgcc tcactatggt ggtaacatgc aagaagagtg caactaatac     3660

tgagagaatg gtcttctcag tagtgcaggc accccgggtg ctgcaaagct gtagggtcgt     3720

ggcagacaaa tactcgtcag tgaatgcagt taagcacgtg aaagcaccag agaagatccc     3780

ttggagtgaa accctagagt acaaggtgaa ttttgtctct ttgactgtgg tgccgaagaa     3840

ggatgtctac aagatcccaa ccgcagtatt gaaggtatcc ggctcgagcc tgtataatct     3900

tgcgctcaat gtcactattg atgtggaggt agacccaaag agcccgttag tcaagtccct     3960

ttctaggtcc gacagtggat actatgctaa tctcttctta catatcggac ttatgtccac     4020

tgtagataag aggggaaaga aagtgacatt tgaccagctg gagaggaaga taaggagact     4080

tgatctatct gtcgggctca gtgatgtgct cggaccttct gtgcttgtga aggcgagagg     4140

tgcacggact aggctgctgg cacctttctt ctctaacagc gggacagcct gctaccctat     4200

agcaaatgcc tctcctcagg tagctaagat actctggagt cagaccgcgt gcctgcggag     4260

tgtaaaaatc attattcaag cgggcaccca acgcgctgtc gcagtgactg ctgaccatga     4320

ggttacctct actaagatag agaagaggca taccatcgct aaatacaatc ccttcaagaa     4380

ataggccgta tccctgagac tgcaattcac ccgccttccc aaaacaccat gacaccagat     4440

aatgatctgt cttgattact tacagttagt ttccctgtct atcaaattag aaaaaacacg     4500

ggtagaagag ttcggatccc ggccggcgca ccaaaagcgc aagatgggcc ccagatcttc     4560

taccaggatc ccagtacctc taatgctgac catacggatc acgctggcac tgagttatgt     4620

ccgtctgaca agttctcttg atggcaggcc tcttgcagcc gcagggatcg tggtaacagg     4680

ggataaagca gttaacatat acacctcatc ccagacaggg tcaatcatag tcaagttact     4740

cccaaatatg cccaaggaca aagaggcatg tgcaaaagcc ccattggagg cttacaacag     4800

gacactgact actttgctta ccccccttgg tgattctatc cgcaggatac aagagtctgt     4860

gactacatcc ggaggaagga gacagagacg ctctataggt gccattattg gcagtgtagc     4920

tctaggggtt gcaacagctg cacagataac ggcagcctcg gctctgatac aagccaacca     4980

gaatgctgct aacatcctcc ggcttaagga gagcattgct gcaaccaatg aagctgtaca     5040

cgaggtcact ggcggattgt cacagttagc agtggcagtt ggaaagatgc agcaatttgt     5100

taatgaccag cttaataaca cagctcaaga gttggactgt ataaaaatta cacagcaggt     5160

tggtgtagaa ctcaacttat acttaactga attgactaca gtgttcgggc cacaaatcac     5220

ttcccctgcc ttaactcagt tgactgttca ggctctttac aatctggctg gtggtaatgt     5280

agattacttg ttgactaagt taggtgtagg gaacaaccag ctcagctcat tgattggtag     5340

cggcttgatc accggtaacc ctatttttta cgactcacag actcaactct tgggcataca     5400

ggtgacttta ccctcagtcg ggaacctaaa taatatgcgt gccacctact tggagacctt     5460

gtctgtaagc acaacaaagg gatttgcctc agcacttgtc ccaaaagtag tgacacaggt     5520

cggttctgtg atagaagagc ttgacacctc atactgtata gaagctgatt tggatttata     5580

ttgtacaaga atagtgacat tccctatgtc ccctggtatt tattcctgtt tgagcggcaa     5640

tacatcggct tgcatgtatt caaggactga aggcgcactt actacaccat acatgactct     5700

caaaggctca gttgttgcca attgccagat gacaacatgt agatgtgcag accccccggg     5760

tatcatatca caaaattatg gagaggctgt gtctctaata gataagcact catgcaatgt     5820

cgtatcctta gacgggataa ctttgaggct cagtggggaa tttgatgcaa cttatcaaaa     5880

gaatatctca atattagatt ctcaagtact agtgacaggc aatctcgata tctcaactga     5940

gcttgggaat gtcaaccact caataagtaa tgctttggat aagttagagg aaagcaacag     6000

caaactagac aaagtcaatg tcaaactgac cagcacatct gctctcatta cctatattgt     6060

tttaactgtc atatctcttg ttcttggtat gcttagcctg gttctagcat gctatctgat     6120

gtacaagcaa aaagcgcaac gaaagacctt gttgtggctt ggaaataata ccctagatca     6180

gatgagagct actacaaaaa tgtgaatgca gatgagaggc agaggtatcc ccaatagcaa     6240

tctgtgtgtc aattctggca gcctgttaat cagaagaatt aagaaaaaac taccggatgt     6300

aggtgaacaa aagggaatat acgggtagaa cggcctgaga ggccacccct caatcgggag     6360

ccaggcccca ctacgtccgc tctaccgcat caccaacagc agtcttcagt catggacagc     6420

gcagttagcc aagttgcgct agagaatgat agaagagaag cgaataatac atggcgcttg     6480

gttttccgga tcgcagcctt acttttactg gtaataacct tagccgtctc tgcagtcgcc     6540

ctggcatata gtatggaggc tagcacacct ggcgaccttg taagcatacc gactgcgatc     6600

tctagggcag aggaaaggat tacatctgca ctcggttcca atcaagatgt agtagatagg     6660

atatacaagc aagtggccct tgagtctcca ttggcactgc taaataccga atctataatt     6720

atgaatgcaa taacgtctct ctcttatcaa atcaatggag ccacaaataa tagcgggtgt     6780

ggggcacctg ttcatgaccc agattacatc ggggggatag gtcaagaact tattgtagat     6840

gatacgagtg acgtcacatc attttatccc tctgcattcc aagaacacct gaattttatc     6900

ccggcgccca ctacaggatc aggctgcact cggataccct cattcgacat gagtgctacc     6960

cattactgtt acactcacaa tgtgatattg tctggctgca gagatcactc acactcacat     7020

cagtatttag cacttggtgt gcttcggaca tctgcaacag ggagggtatt cttttctact     7080

ctgcgttcca tcaacttgga tgacgcccaa aatcggaagt cttgcagtgt gagtgcaact     7140

cctttaggtt gtgatatgct gtgctctaaa atcacagaga ctgaggaaga ggattataaa     7200

tcagttatcc ccacatcgat ggtacatgga aggttagggc ttgacggcca ataccatgag     7260

aaggacctag acgtcacaac actatttagg gactgggtgg caaattaccc aggagtagga     7320

ggtgggtctt ttattaacaa tcgcgtatgg ttcccggtct acggagggct aaaacccagc     7380

tcgcctagtg acactgcaca agaagggaga tacgtaatat acaagcgata caatgacaca     7440

tgcccggatg agcaagatta ccagattcgg atggctaagt catcgtataa gcctaggcgg     7500

tttggtggaa aacgcgtaca gcaggccatc ctatccatca aggtgtcaac atccttgggt     7560

gaggacccgg tgttgactgt accgcctaat acggtcgcac tcatgggggc cgaaggcaga     7620

gttctcacag tggggacatc tcatttctta tatcagcgag ggtcatcata cttctctccc     7680

gctttgttat accctatgac agtcaacaac aaaacagcca ctcttcataa tccttataca     7740

ttcaatgctt tcactcggcc aggtagtgtc ccttgccagg cttcagcaag atgccccaac     7800

tcatgtgtta ccggagtcta tactgatcca tatcccttag tcttccatag gaaccacacc     7860

ttgcgagggg tattcggaac aatgcttgat gacgaacaag caagactcaa ccctgtatct     7920

gcagtatttg ataacatatc ccgcagtcgc ataactcggg taagttcaag cagtaccagg     7980

gcagcataca cgacatcaac gtgttttaaa gttgtcaaga ccaataaaac ctattgcctc     8040

agcattgcag aaatatccaa taccctcttc ggggaattca gaattgtccc cttactagtt     8100

gagattctca aggatggtgg ggtttaagaa gctaggaatg gtcggttgag tcaaccgtga     8160

gaaggcgggg aagatgatat tgcatcatct atcttctgta acaccaagaa tcaaatcgaa     8220

taccagtgcg agctcgaatc ctacgctgcc agtcagccat aatcggctgg tgctaatgtg     8280

gttagcctga atcttgtcga tagtcacttg attaagaaaa aatgtggacg gtagtgaaat     8340

ataaggcaaa gcagctcaca gaggacagca cgggtaggac atggcgggct ccggacccga     8400

aagggcagag catcagatta tcctaccaga gtcacatctg tcctcaccat tggtcaagca     8460

taaattgctt tattactgga aattaactgg gctaccgctt cctgacgaat gtgacttcga     8520

ccatcttatt atcagccgac aatggaagaa ggtacttgaa tcggccaccc ctgacattga     8580

gagaatgata aaactagggc gggcagtaca ccagactctc aaccacaatt ccaggataac     8640

cggagtactc catccccggt gtttagagga actggctagt attgaggttc ctgattcaac     8700

caacaaattt cggaagatcg aaaaaaagat ccagattcac aacacaaggt atggagaact     8760

gttcacaaga ttatgcacgc atgtagaaaa gaaactattg gggtcatctt ggtctaacaa     8820

tgtcccacgg tcagaggaat tcaacagcat ccgtacagat ccggcatttt ggtttcactc     8880

aaaatggtcc acagccaaat ttgcatggct ccatataaaa caggtccaga ggcatctgat     8940

tgtagcagca agaacaaggt ccgcagtcaa caaattagtg acgctgaccc ataaggtagg     9000

ccaaatcttt gttactcctg agcttgtcat tgtgacacat acagatgaga acaagttcac     9060

gtgtcttacc caggaacttg tgttgatgta tgcagatatg atggagggca gagatatggt     9120

cagcataata tcatccacgg cggcacatct taggagctta tcagagaaaa ttgatgatat     9180

tctgcggtta gtagatgctc tggcaagaga tttgggcaat caagtctacg atgttgtagc     9240

actaatggag ggattcgcat acggcgctgt tcagctgctt gaaccgtcag gtacatttgc     9300

gggggatttc ttcgcattca acctgcagga gctcaaagat actctaaccg gactcctccc     9360

caaggatatc gcagaatctg tgactcacgc aatcgcaacc atattctctg gcttagaaca     9420

aaatcaagca gctgagatgt tgtgcctgtt gcgtctgtgg ggtcacccac tactcgagtc     9480

ccgtattgca gcaaaagcag ttaggagtca aatgtgcgca ccaaaaatgg tagactttga     9540

tatgatcctc caggtattat ctttctttaa aggaacaatc atcaatggat atagaaagaa     9600

gaatgcaggc gtgtggccac gtgtcaagat agatacgata tacgggaagg tcatagggca     9660

gctacacgca gattctgcag agatttcaca tgatgtcatg ttgagggaat acaagagttt     9720

atctgcactt gaattcgagc catgtataga gtatgaccct gtcaccaatc tgagcatgtt     9780

tttaaaagac aaggcaatcg cacacccgaa agacaactgg ctcgcttcgt ttaggcgaaa     9840

ccttctctct gaggaccaga agaaacatgt aagagaggca acctcaacta accgcctctt     9900

gatagagttc ttagagtcaa atgattttga tccatataaa gagatggaat atctgacgac     9960

ccttgagtac ctaagagatg ataatgtggc agtatcatac tcactcaaag aaaaagaggt    10020

gaaagttaat gggcggattt tcgcaaagct aacaaataga ttaaggaatt gtcaggtaat    10080

ggcagaaggg atcctagctg accagattgc acctttcttc cagggaaatg gggtcattca    10140

ggatagcata tctttgacta aaagtatgct agcgatgagt caactgtctt tcaacagcaa    10200

caagaaacgt attactgact gcaaagaaag agtatcctca aaccgcaatc atgatccgaa    10260

gagcaagaat cgtcggagag ttgccacttt tgtaactacc gacctgcaaa agtattgtct    10320

caattggaga tatcagacag tcaagctgtt cgctcatgcc atcaatcagc tgatgggctt    10380

acctcacttc ttcgagtgga ttcatcttag actaatggat actacgatgt ttgtagggga    10440

ccctttcaat cctccaagtg accctacgga ctgtgatcta tcaagagtcc caaatgatga    10500

catatatatt gtcagtgcta ggggaggcat tgagggatta tgccagaagc tatggacaat    10560

gatctcaatt gctgcaatcc agcttgctgc agcaagatca cattgtcgcg ttgcctgtat    10620

ggtacaaggc gacaatcaag taatagctat aacgagagag gtaagatcag atgactcccc    10680

agagatggtg ttaacacaat tgcatcaagc cagtgataat ttcttcaagg aattgattca    10740

tgtcaatcat ttgatcggcc ataatttgaa ggatcgtgaa accatcaggt cagacacgtt    10800

cttcatatac agcaaacgaa tattcaaaga tggagcaata ctcagtcagg tcctcaaaaa    10860

ctcatctaaa ttagtgctaa tatcaggcga ccttagtgaa aacactgtaa tgtcttgtgc    10920

caacattgca tctactgtag cacggttatg cgagaacggg cttcctaagg atttctgtta    10980

ttacttaaac tacttaatga gttgcgtgca gacatacttc gattccgaat tttccatcac    11040

caacaactcg caactcgatt ctaaccagtc gtggatagag gacatttctt ttgtgcactc    11100

atatgtcctg acccctgctc aactgggggg actgagtaac cttcaatact caaggctcta    11160

cacaaggaac atcggcgacc cgggaaccac tgctttcgca gagatcaaga gattagaggc    11220

agtggggtta ctgagtccta gcattatgac taacatctta actaggccgc ctggaaatgg    11280

agattgggcc agtctgtgca acgatccata ctcctttaat tttgagactg tcgcaagccc    11340

aaatattgtc cttaagaaac atacacaaag agtcctattt gaaacttgct cgaatccctt    11400

attatctgga gtgcacacag aggataatga ggcagaagag aaggcattgg ctgaattctt    11460

gctcaatcaa gaaatgattc atccacgtgt cgcgcatgct atcatggaag caagctctgt    11520

aggtaggaga aagcaaattc aggggcttgt tgacacaaca aacaccgtga ttaagattgc    11580

actgactagg aggccactcg gcatcaagag gctgatgcgg atagtcaatt actcgagcat    11640

gcatgcaatg ctatttagag atgatgtttt ctcgtctaat agatccaacc atcccttagt    11700

ctcttctgat atgtgttctc agacactggc agactatgca cggaacagaa gctggtcacc    11760

tttgacaggg ggtagaaaaa tactgggtgt atctaatcct gataccatag aacttgtaga    11820

gggtgagatc cttagtgtca gtggagggtg cactagatgt gacagtgggg atgaacagtt    11880

tacttggttc catcttccaa gcaatataga gctaaacgat gacaccagca agaatcctcc    11940

aatgagagtg ccatatctcg ggtcaaagac tcaagagagg agagccgcct cgcttgcgaa    12000

aatagctcat atgtcaccac acgtgaaggc ggctctaagg gcgtcatctg tgttaatctg    12060

ggcttatggg gacaacgaaa taaactggac tgctgccctt aagattgcaa ggtctcggtg    12120

caacataagc tcagagtatc ttcgactatt gtcacccttg cctacagctg ggaatctcca    12180

acatagattg gacgacggca taactcagat gacattcacc cctgcatctc tatacagggt    12240

gtcaccttac attcatatat ctaatgattc tcaaaggcta tttactgaag aaggagtcaa    12300

agaggggaat gtggtttatc agcaaatcat gctcttgggt ttgtccttaa ttgagtcact    12360

cttcccaatg acaacaacca agacatatga tgaaatcaca ttgcacctcc acagtaaatt    12420

tagctgctgt atcagggaag cacctgttgc agttcctttc gagctactcg gggtggcacc    12480

ggaactaagg gcagtaacct caaataagtt tatgtatgat cctagccctg tatcagaggg    12540

agactttgcg agacttgact tagctatctt taagagttat gaacttaatt tagagtcata    12600

ttccacaata gagctaatga acgttctttc aatatctagt gggaagttga ttggccagtc    12660

tgtggtttct tatgatgaag atacctccat aaagaatgac gctataatag tgtatgacaa    12720

cacacggaat tggatcagcg aagctcagaa ttcagatgtg gtccgcctat tcgagtatgc    12780

ggcactcgaa gtgctcctcg actgttctta tcaactctac tatctgagag taagaggcct    12840

aaacaatatc gtcctgtaca tgagtgattt atacaagaat atgccaggaa ttctactctc    12900

taatattgca gccacaatat ctcaccctgt catccattca aggttgaatg cagtaggtct    12960

ggtcaaccat gacgggtcac accaacttgc agacacagat ttcattgaaa tgtctgcaaa    13020

gctgctagtc tcttgcactc gacgcgtggt ctcaggttta catgcaggga ataagtatga    13080

cctgctgttt ccatctgtct tggatgataa cctaagtgag aagatgcttc agttgatatc    13140

ccaattatgc tgtctgtata cggtgctctt tgctacaaca agagaaatcc cgaaaataag    13200

aggcttatct gcagaagaga aatgttcagt acttactgag tacctactgt cagatgctgt    13260

gaaaccgtta cttgggtccg agcaagtgag ctctatcatg tctcccaaca tagttacgtt    13320

cccagccaat ctgtattaca tgtctaggaa gagccttaat ttgatcaggg agagagagga    13380

cagggatact atcttggcat tgttgttccc tcaagaaccg ctgctcgagt ttcctctggt    13440

acgagatatt ggtgctcgtg taaaagatcc atttacccta caacctgcgg cgtttttaca    13500

agagttagat ttgagtgctc cggcaaggta tgacgcattc acaatcagtc aggcgcattc    13560

tgaacacata ttgccaaacc cagaggaaga tcacttagta cgatacttgt tcagaggaat    13620

agggactgcg tcctcctctt ggtataaggc atcccatctt ctttctgtac ccgaggtcag    13680

atgtgcaagg catgggaact ccttatattt agcagaagga agtggagcca tcatgagtct    13740

tctcgaattg catataccac acgaaactat ctattacaat acacttttct cgaacgagat    13800

gaacccccca cagcgacatt tcggaccaac tccaacacag tttctgaatt cggttgtttt    13860

taggaattta caggcggaag taccatgcaa ggatggattt gtccaggagt tccgtccgtt    13920

atggagagag aatacagaag aaagcgatct gacctcagat aaagcagtgg gatatatcac    13980

atctgtagtg ccgtacaggt ctgtatcatt gctgcattgt gacattgaaa tccctccagg    14040

atctaatcaa agcttactag atcagctggc taccaatctg tctctgattg ccatgcattc    14100

tgtgaaggag ggcggggtcg tgattatcaa agtactgtat gcaatgggat attacttcca    14160

tctactcatg aacttgttta ctccatgttc cacgaaagga tatattctct ctaatggcta    14220

tgcctgtaga ggggatatgg agtgttacct gatatttgtc atgggctacc taggcgggcc    14280

tacatttgta catgaggtgg tgaggatggc aaaaacgcta gtacagcggc atggcacact    14340

tttgtctaag tcagatgaga ttacactgac taggttattt acttcacagc aacagcgtgt    14400

aacagacatc ctatccagcc ctttaccgag actaatgaag tacttgagag agaatattga    14460

tactgcactg attgaagccg ggggacagcc tgtccgtcca ttctgtgcag agagtttagt    14520

gagcacacta acagacatga ctcagacaac ccagatcatc gccagccaca ttgatacagt    14580

cattcgatct gtgatctata tggaagcaga gggtgatctt gctgacacag tattcttatt    14640

taccccttac aacctctcta tggacgggaa aaagagaaca tcacttaaac agtgcacaag    14700

acagatctta gaggtcacaa tactgggtct cagagtcaaa aatctcaata aagtaggtga    14760

tgtaatcagc ctagtactca gaggtatgat ttctctggag gaccttctcc cactgagaac    14820

ctacttgaag tgtagtacct gccctaagta tttgaaggct gtcctaggta ttaccaaact    14880

caaagaaatg ttcacagacg cctctttatt atacttgact cgtgctcaac aaaaattcta    14940

catgaaaact ataggcaatg cagtcaaggg atactatagt aactgtgact cttaaaggca    15000

accacatatc aataggccct ctttctagcc gatcgtattc ttgttgactt cattatacca    15060

tattagaaaa aaattgaatt ccgacccttt aagactcgta ttcggattca aataattatc    15120

tcagaaaaaa agtgcacgta gttgttcttg attatagtcc cgtcattcac caagtctttg    15180

tttggt                                                               15186




<210> 5
<211> 15198
<212> DNA
<213> Newcastle disease virus


<220> 
<223> Mut HN
      (F277L)/M(G165W)/F(F117S)/F(F190L)/L(V757I)/L(F1551S)/L(R1700L)+AfeI


<400> 5
accaaacaga gaatccgtga gatacgataa aaggcgaagg agcaatcgaa gtcgtacggg       60

tagaaggtgt gaatctcgag tgcgagaccg aagcttaaac tcgagagagc cttctgccaa      120

catgtcttcc gtatttgacg agtatgaaca gctcctcgcg gctcagactc gccctaatgg      180

agctcacgga ggaggagaga aggggagcac cttaaaagtt gaagtcccgg tattcactct      240

taacagtgac gacccagaag atagatggaa ctttgcagta ttctgtctta ggattgctgt      300

tagcgaagat gccaacaaac cactcagaca aggtgctctc atatctctct tatgctccca      360

ttctcaagtg atgaggaacc atgtcgccct tgcagggaaa cagaatgagg ccacactggc      420

tgttcttgag atcgatggtt tcaccaacag cgtgcctcaa tttaacaaca ggagtggagt      480

gtctgaggag agagcacaga gattcttgat gatagcaggg tccctccctc gggcatgcag      540

caacggtacc ccgttcatca cagctggggt tgaagatgat gcaccagaag acatcactga      600

tactctggaa agaatcatct ctatccaggc tcaagtatgg gtcacggtag caaaggccat      660

gactgcatat gagacagcgg atgagtcgga aacaagaaga atcaataagt atatgcagca      720

aggcagagtc caaaagaagt acatcctcca ccccgtatgt aggagcgcaa ttcaactcac      780

gattagacaa tctctggcag tccgcatttt cttggttagc gagcttaaga gaggccgcaa      840

cacggcaggt ggaagttcca cttattatag cttggtaggg gacatagact catacatcag      900

gaacaccggg cttactgcat tcttcctgac actcaggtat ggaattaaca ccaagacatc      960

agcccttgca ctcagcagcc tcgcaggcga tatccaaaaa atgaagcagc tcatgcgtct     1020

atatcggatg aaaggagata atgcgccgta catgacactg ctcggtgaca gtgaccagat     1080

gagctttgca ccggctgagt atgcacaact ctactctttt gcaatgggta tggcatccgt     1140

cctagacaaa ggaactggca agtaccagtt cgccagagac tttatgagca catcattctg     1200

gagacttgga gtagagtatg ctcgggctca gggaagcagc atcaatgagg atatggctgc     1260

cgagctaaag ctgaccccag cggcaaggag gggcctggca gctgctgccc aacgagcgtc     1320

cgaggagacc ggcagcatgg acattcccac tcaacaagct ggggtcctca cagggctcag     1380

cgacggaggc cctcaagccc cacaaggtgg actgaacagg tcgcaagggc aaccggacgc     1440

cggagatggg gagacccaat ttttagattt gatgagagca gtggcaaata gtatgagaga     1500

agcgccaaac tctgtgcaga acaccactca gcaggagcct ccatctactc ctgggccatc     1560

tcaagacaac gacaccgact ggggatactg accgacaaca ctcagcctgc ctccatcgaa     1620

ttatctcgat tcttctgcct gtaacctaac ccctggtcca cagtctcaca cggccaaacc     1680

cgcaaacgag cccccccctc tctccccccc cctccagcca cacggctcca accgcccaaa     1740

acaacacggg cacaactcga ctcactcata atctacacag agccgaagat cttagaaaaa     1800

aatacgggta gaagagagac attcagagat caggacaaat catcagggtc tccgctctcc     1860

cctctaccca gcagaccaga gtgaagatgg ccaccttcac ggatgcagag atcgacgatc     1920

tatttgaaac cagtggaact gtcattgaca gcataattac ggcccaaggc aacccagtag     1980

agactgttgg aaggagcgca atcccacaag gcaaaactaa agcattgagt gcagcatggg     2040

agaaacatgg aagcacccaa ccgccggccg gccaagacac ccctgatcga atggacagat     2100

cagacaaaca accatcccca cccgaacagg caaccacaca caacagcccg ccagccacat     2160

ccaccgacca gccccccacc caggccgcag gcgaagccgg tgacacacag ctcaagactg     2220

gagcaagcaa ctccctcctg tcgatgctcg acaagcttag caataaatcg tccaatgcta     2280

aaaagggccc acggtcgagt ccccaggaag ggcaccacca acctccgacc cagcagcaag     2340

ggagtcaaca gagccgcgga aacagtcagg agagatcgca aaaccaggtc aaggccgcct     2400

ctggagacca gggcacagac gcgaacacag catatcatgg acaatggaag gagtcacaac     2460

catcagctgg tgcaatccct catgctctcc ggtcagggca gagccaagcc aatactcctg     2520

catctgtgga tcatgtccag ctacctgtcg actttgtgca ggcgatgatg tctatgatgg     2580

aggcgatatc acagaaggta aataaagtcg actatcagct agaccttgtc tcaaagcaga     2640

catcctccat ccccatgatg cgatctgaaa tccaacagct gaaaacatcc gttgcggtca     2700

tggaagccaa cctgggcatg atgaagattc tggaccctgg ttgtgctaac gtttcatctt     2760

taagtgacct acgggcggtc gcccgctctc acccagtttt agtttcaggc cccggagacc     2820

catctcctta tgtgacacaa gggggtgaat tgatactcaa taaactctcg caaccagtgc     2880

aacatccttc tgagttgatt aaacctgcca cgataagcgg gcctgatata ggagtggaga     2940

aggacactgt ccgtgcattg atcacctcac gcccaatgca tccgagctct tcagctaagc     3000

tcctgagtaa gctggatgca gccgggtcga tagaagaaat taggaaaatc aaacgccttg     3060

cgctgaatgg ctgatcacta ctacaacccg caacgggttc ccgtttatct attgtcacaa     3120

ggaacccgcc ccgaagcgct gaccgagccc tcctctataa acccaagatt caaggctcca     3180

agcgataacc ttctcccgcc tcttccatcc cactgaatga tcgcgcagct gcaattaatc     3240

tagcaacatt aaagattaag aaaaaatacg ggtagaatcg gagtgcaccg attgtgccaa     3300

gatggactca tctaggacaa ttgggttata ctttgattct gcccttcctt ctagcaacct     3360

gttagcattc ccgattgtct tacgagatgt aggagatgga aagaagcaaa ttactccgca     3420

atataggatc cggcgtcttg actcgtggac agacagtaaa gaagactcgg tattcatcac     3480

tacctacgga ttcatcttcc aggttgggaa tgaagaagtc actgtcggca tgatcaatga     3540

taatcccaag cgagagttac tctccgctgc gatgctctgc ctaggaagcg tcccgaatgt     3600

tggagatcct gttgagctgg caagggcctg cctcactatg gtggtaacat gcaagaagag     3660

tgcaactaat actgagagaa tggtcttctc agtagtgcag gcaccccggg tgctgcaaag     3720

ctgtagggtc gtggcagaca aatactcgtc agtgaatgca gttaagcacg tgaaagcacc     3780

agagaagatc ccttggagtg aaaccctaga gtacaaggtg aattttgtct ctttgactgt     3840

ggtgccgaag aaggatgtct acaagatccc aaccgcagta ttgaaggtat ccggctcgag     3900

cctgtataat cttgcgctca atgtcactat tgatgtggag gtagacccaa agagcccgtt     3960

agtcaagtcc ctttctaggt ccgacagtgg atactatgct aatctcttct tacatatcgg     4020

acttatgtcc actgtagata agaggggaaa gaaagtgaca tttgaccagc tggagaggaa     4080

gataaggaga cttgatctat ctgtcgggct cagtgatgtg ctcggacctt ctgtgcttgt     4140

gaaggcgaga ggtgcacgga ctaggctgct ggcacctttc ttctctaaca gcgggacagc     4200

ctgctaccct atagcaaatg cctctcctca ggtagctaag atactctgga gtcagaccgc     4260

gtgcctgcgg agtgtaaaaa tcattattca agcgggcacc caacgcgctg tcgcagtgac     4320

tgctgaccat gaggttacct ctactaagat agagaagagg cataccatcg ctaaatacaa     4380

tcccttcaag aaataggccg tatccctgag actgcaattc acccgccttc ccaaaacacc     4440

atgacaccag ataatgatct gtcttgatta cttacagtta gtttccctgt ctatcaaatt     4500

agaaaaaaca cgggtagaag agttcggatc ccggccggcg caccaaaagc gcaagatggg     4560

ccccagatct tctaccagga tcccagtacc tctaatgctg accatacgga tcacgctggc     4620

actgagttat gtccgtctga caagttctct tgatggcagg cctcttgcag ccgcagggat     4680

cgtggtaaca ggggataaag cagttaacat atacacctca tcccagacag ggtcaatcat     4740

agtcaagtta ctcccaaata tgcccaagga caaagaggca tgtgcaaaag ccccattgga     4800

ggcttacaac aggacactga ctactttgct tacccccctt ggtgattcta tccgcaggat     4860

acaagagtct gtgactacat ccggaggaag gagacagaga cgctctatag gtgccattat     4920

tggcagtgta gctctagggg ttgcaacagc tgcacagata acggcagcct cggctctgat     4980

acaagccaac cagaatgctg ctaacatcct ccggcttaag gagagcattg ctgcaaccaa     5040

tgaagctgta cacgaggtca ctggcggatt gtcacagtta gcagtggcag ttggaaagat     5100

gcagcaattt gttaatgacc agcttaataa cacagctcaa gagttggact gtataaaaat     5160

tacacagcag gttggtgtag aactcaactt atacttaact gaattgacta cagtgttcgg     5220

gccacaaatc acttcccctg ccttaactca gttgactgtt caggctcttt acaatctggc     5280

tggtggtaat gtagattact tgttgactaa gttaggtgta gggaacaacc agctcagctc     5340

attgattggt agcggcttga tcaccggtaa ccctattttt tacgactcac agactcaact     5400

cttgggcata caggtgactt taccctcagt cgggaaccta aataatatgc gtgccaccta     5460

cttggagacc ttgtctgtaa gcacaacaaa gggatttgcc tcagcacttg tcccaaaagt     5520

agtgacacag gtcggttctg tgatagaaga gcttgacacc tcatactgta tagaagctga     5580

tttggattta tattgtacaa gaatagtgac attccctatg tcccctggta tttattcctg     5640

tttgagcggc aatacatcgg cttgcatgta ttcaaggact gaaggcgcac ttactacacc     5700

atacatgact ctcaaaggct cagttgttgc caattgccag atgacaacat gtagatgtgc     5760

agaccccccg ggtatcatat cacaaaatta tggagaggct gtgtctctaa tagataagca     5820

ctcatgcaat gtcgtatcct tagacgggat aactttgagg ctcagtgggg aatttgatgc     5880

aacttatcaa aagaatatct caatattaga ttctcaagta ctagtgacag gcaatctcga     5940

tatctcaact gagcttggga atgtcaacca ctcaataagt aatgctttgg ataagttaga     6000

ggaaagcaac agcaaactag acaaagtcaa tgtcaaactg accagcacat ctgctctcat     6060

tacctatatt gttttaactg tcatatctct tgttcttggt atgcttagcc tggttctagc     6120

atgctatctg atgtacaagc aaaaagcgca acgaaagacc ttgttgtggc ttggaaataa     6180

taccctagat cagatgagag ctactacaaa aatgtgaatg cagatgagag gcagaggtat     6240

ccccaatagc aatctgtgtg tcaattctgg cagcctgtta atcagaagaa ttaagaaaaa     6300

actaccggat gtaggtgaac aaaagggaat atacgggtag aacggcctga gaggccaccc     6360

ctcaatcggg agccaggccc cactacgtcc gctctaccgc atcaccaaca gcagtcttca     6420

gtcatggaca gcgcagttag ccaagttgcg ctagagaatg atagaagaga agcgaataat     6480

acatggcgct tggttttccg gatcgcagcc ttacttttac tggtaataac cttagccgtc     6540

tctgcagtcg ccctggcata tagtatggag gctagcacac ctggcgacct tgtaagcata     6600

ccgactgcga tctctagggc agaggaaagg attacatctg cactcggttc caatcaagat     6660

gtagtagata ggatatacaa gcaagtggcc cttgagtctc cattggcact gctaaatacc     6720

gaatctataa ttatgaatgc aataacgtct ctctcttatc aaatcaatgg agccacaaat     6780

aatagcgggt gtggggcacc tgttcatgac ccagattaca tcggggggat aggtcaagaa     6840

cttattgtag atgatacgag tgacgtcaca tcattttatc cctctgcatt ccaagaacac     6900

ctgaatttta tcccggcgcc cactacagga tcaggctgca ctcggatacc ctcattcgac     6960

atgagtgcta cccattactg ttacactcac aatgtgatat tgtctggctg cagagatcac     7020

tcacactcac atcagtattt agcacttggt gtgcttcgga catctgcaac agggagggta     7080

ttcttttcta ctctgcgttc catcaacttg gatgacgccc aaaatcggaa gtcttgcagt     7140

gtgagtgcaa ctcctttagg ttgtgatatg ctgtgctcta aaatcacaga gactgaggaa     7200

gaggattata aatcagttat ccccacatcg atggtacatg gaaggttagg gcttgacggc     7260

caataccatg agaaggacct agacgtcaca acactattta gggactgggt ggcaaattac     7320

ccaggagtag gaggtgggtc ttttattaac aatcgcgtat ggttcccggt ctacggaggg     7380

ctaaaaccca gctcgcctag tgacactgca caagaaggga gatacgtaat atacaagcga     7440

tacaatgaca catgcccgga tgagcaagat taccagattc ggatggctaa gtcatcgtat     7500

aagcctaggc ggtttggtgg aaaacgcgta cagcaggcca tcctatccat caaggtgtca     7560

acatccttgg gtgaggaccc ggtgttgact gtaccgccta atacggtcgc actcatgggg     7620

gccgaaggca gagttctcac agtggggaca tctcatttct tatatcagcg agggtcatca     7680

tacttctctc ccgctttgtt ataccctatg acagtcaaca acaaaacagc cactcttcat     7740

aatccttata cattcaatgc tttcactcgg ccaggtagtg tcccttgcca ggcttcagca     7800

agatgcccca actcatgtgt taccggagtc tatactgatc catatccctt agtcttccat     7860

aggaaccaca ccttgcgagg ggtattcgga acaatgcttg atgacgaaca agcaagactc     7920

aaccctgtat ctgcagtatt tgataacata tcccgcagtc gcataactcg ggtaagttca     7980

agcagtacca gggcagcata cacgacatca acgtgtttta aagttgtcaa gaccaataaa     8040

acctattgcc tcagcattgc agaaatatcc aataccctct tcggggaatt cagaattgtc     8100

cccttactag ttgagattct caaggatggt ggggtttaag aagctaggaa tggtcggttg     8160

agtcaaccgt gagaaggcgg ggaagatgat attgcatcat ctatcttctg taacaccaag     8220

aatcaaatcg aataccagtg cgagctcgaa tcctacgctg ccagtcagcc ataatcggct     8280

ggtgctaatg tggttagcct gaatcttgtc gatagtcact tgattaagaa aaaatgtgga     8340

cggtagtgaa atataaggca aagcagctca cagaggacag cacgggtagg acatggcggg     8400

ctccggaccc gaaagggcag agcatcagat tatcctacca gagtcacatc tgtcctcacc     8460

attggtcaag cataaattgc tttattactg gaaattaact gggctaccgc ttcctgacga     8520

atgtgacttc gaccatctta ttatcagccg acaatggaag aaggtacttg aatcggccac     8580

ccctgacatt gagagaatga taaaactagg gcgggcagta caccagactc tcaaccacaa     8640

ttccaggata accggagtac tccatccccg gtgtttagag gaactggcta gtattgaggt     8700

tcctgattca accaacaaat ttcggaagat cgaaaaaaag atccagattc acaacacaag     8760

gtatggagaa ctgttcacaa gattatgcac gcatgtagaa aagaaactat tggggtcatc     8820

ttggtctaac aatgtcccac ggtcagagga attcaacagc atccgtacag atccggcatt     8880

ttggtttcac tcaaaatggt ccacagccaa atttgcatgg ctccatataa aacaggtcca     8940

gaggcatctg attgtagcag caagaacaag gtccgcagtc aacaaattag tgacgctgac     9000

ccataaggta ggccaaatct ttgttactcc tgagcttgtc attgtgacac atacagatga     9060

gaacaagttc acgtgtctta cccaggaact tgtgttgatg tatgcagata tgatggaggg     9120

cagagatatg gtcagcataa tatcatccac ggcggcacat cttaggagct tatcagagaa     9180

aattgatgat attctgcggt tagtagatgc tctggcaaga gatttgggca atcaagtcta     9240

cgatgttgta gcactaatgg agggattcgc atacggcgct gttcagctgc ttgaaccgtc     9300

aggtacattt gcgggggatt tcttcgcatt caacctgcag gagctcaaag atactctaac     9360

cggactcctc cccaaggata tcgcagaatc tgtgactcac gcaatcgcaa ccatattctc     9420

tggcttagaa caaaatcaag cagctgagat gttgtgcctg ttgcgtctgt ggggtcaccc     9480

actactcgag tcccgtattg cagcaaaagc agttaggagt caaatgtgcg caccaaaaat     9540

ggtagacttt gatatgatcc tccaggtatt atctttcttt aaaggaacaa tcatcaatgg     9600

atatagaaag aagaatgcag gcgtgtggcc acgtgtcaag atagatacga tatacgggaa     9660

ggtcataggg cagctacacg cagattctgc agagatttca catgatgtca tgttgaggga     9720

atacaagagt ttatctgcac ttgaattcga gccatgtata gagtatgacc ctgtcaccaa     9780

tctgagcatg tttttaaaag acaaggcaat cgcacacccg aaagacaact ggctcgcttc     9840

gtttaggcga aaccttctct ctgaggacca gaagaaacat gtaagagagg caacctcaac     9900

taaccgcctc ttgatagagt tcttagagtc aaatgatttt gatccatata aagagatgga     9960

atatctgacg acccttgagt acctaagaga tgataatgtg gcagtatcat actcactcaa    10020

agaaaaagag gtgaaagtta atgggcggat tttcgcaaag ctaacaaata gattaaggaa    10080

ttgtcaggta atggcagaag ggatcctagc tgaccagatt gcacctttct tccagggaaa    10140

tggggtcatt caggatagca tatctttgac taaaagtatg ctagcgatga gtcaactgtc    10200

tttcaacagc aacaagaaac gtattactga ctgcaaagaa agagtatcct caaaccgcaa    10260

tcatgatccg aagagcaaga atcgtcggag agttgccact tttgtaacta ccgacctgca    10320

aaagtattgt ctcaattgga gatatcagac agtcaagctg ttcgctcatg ccatcaatca    10380

gctgatgggc ttacctcact tcttcgagtg gattcatctt agactaatgg atactacgat    10440

gtttgtaggg gaccctttca atcctccaag tgaccctacg gactgtgatc tatcaagagt    10500

cccaaatgat gacatatata ttgtcagtgc taggggaggc attgagggat tatgccagaa    10560

gctatggaca atgatctcaa ttgctgcaat ccagcttgct gcagcaagat cacattgtcg    10620

cgttgcctgt atggtacaag gcgacaatca agtaatagct ataacgagag aggtaagatc    10680

agatgactcc ccagagatgg tgttaacaca attgcatcaa gccagtgata atttcttcaa    10740

ggaattgatt catgtcaatc atttgatcgg ccataatttg aaggatcgtg aaaccatcag    10800

gtcagacacg ttcttcatat acagcaaacg aatattcaaa gatggagcaa tactcagtca    10860

ggtcctcaaa aactcatcta aattagtgct aatatcaggc gaccttagtg aaaacactgt    10920

aatgtcttgt gccaacattg catctactgt agcacggtta tgcgagaacg ggcttcctaa    10980

ggatttctgt tattacttaa actacttaat gagttgcgtg cagacatact tcgattccga    11040

attttccatc accaacaact cgcaactcga ttctaaccag tcgtggatag aggacatttc    11100

ttttgtgcac tcatatgtcc tgacccctgc tcaactgggg ggactgagta accttcaata    11160

ctcaaggctc tacacaagga acatcggcga cccgggaacc actgctttcg cagagatcaa    11220

gagattagag gcagtggggt tactgagtcc tagcattatg actaacatct taactaggcc    11280

gcctggaaat ggagattggg ccagtctgtg caacgatcca tactccttta attttgagac    11340

tgtcgcaagc ccaaatattg tccttaagaa acatacacaa agagtcctat ttgaaacttg    11400

ctcgaatccc ttattatctg gagtgcacac agaggataat gaggcagaag agaaggcatt    11460

ggctgaattc ttgctcaatc aagaaatgat tcatccacgt gtcgcgcatg ctatcatgga    11520

agcaagctct gtaggtagga gaaagcaaat tcaggggctt gttgacacaa caaacaccgt    11580

gattaagatt gcactgacta ggaggccact cggcatcaag aggctgatgc ggatagtcaa    11640

ttactcgagc atgcatgcaa tgctatttag agatgatgtt ttctcgtcta atagatccaa    11700

ccatccctta gtctcttctg atatgtgttc tcagacactg gcagactatg cacggaacag    11760

aagctggtca cctttgacag ggggtagaaa aatactgggt gtatctaatc ctgataccat    11820

agaacttgta gagggtgaga tccttagtgt cagtggaggg tgcactagat gtgacagtgg    11880

ggatgaacag tttacttggt tccatcttcc aagcaatata gagctaaacg atgacaccag    11940

caagaatcct ccaatgagag tgccatatct cgggtcaaag actcaagaga ggagagccgc    12000

ctcgcttgcg aaaatagctc atatgtcacc acacgtgaag gcggctctaa gggcgtcatc    12060

tgtgttaatc tgggcttatg gggacaacga aataaactgg actgctgccc ttaagattgc    12120

aaggtctcgg tgcaacataa gctcagagta tcttcgacta ttgtcaccct tgcctacagc    12180

tgggaatctc caacatagat tggacgacgg cataactcag atgacattca cccctgcatc    12240

tctatacagg gtgtcacctt acattcatat atctaatgat tctcaaaggc tatttactga    12300

agaaggagtc aaagagggga atgtggttta tcagcaaatc atgctcttgg gtttgtcctt    12360

aattgagtca ctcttcccaa tgacaacaac caagacatat gatgaaatca cattgcacct    12420

ccacagtaaa tttagctgct gtatcaggga agcacctgtt gcagttcctt tcgagctact    12480

cggggtggca ccggaactaa gggcagtaac ctcaaataag tttatgtatg atcctagccc    12540

tgtatcagag ggagactttg cgagacttga cttagctatc tttaagagtt atgaacttaa    12600

tttagagtca tattccacaa tagagctaat gaacgttctt tcaatatcta gtgggaagtt    12660

gattggccag tctgtggttt cttatgatga agatacctcc ataaagaatg acgctataat    12720

agtgtatgac aacacacgga attggatcag cgaagctcag aattcagatg tggtccgcct    12780

attcgagtat gcggcactcg aagtgctcct cgactgttct tatcaactct actatctgag    12840

agtaagaggc ctaaacaata tcgtcctgta catgagtgat ttatacaaga atatgccagg    12900

aattctactc tctaatattg cagccacaat atctcaccct gtcatccatt caaggttgaa    12960

tgcagtaggt ctggtcaacc atgacgggtc acaccaactt gcagacacag atttcattga    13020

aatgtctgca aagctgctag tctcttgcac tcgacgcgtg gtctcaggtt tacatgcagg    13080

gaataagtat gacctgctgt ttccatctgt cttggatgat aacctaagtg agaagatgct    13140

tcagttgata tcccaattat gctgtctgta tacggtgctc tttgctacaa caagagaaat    13200

cccgaaaata agaggcttat ctgcagaaga gaaatgttca gtacttactg agtacctact    13260

gtcagatgct gtgaaaccgt tacttgggtc cgagcaagtg agctctatca tgtctcccaa    13320

catagttacg ttcccagcca atctgtatta catgtctagg aagagcctta atttgatcag    13380

ggagagagag gacagggata ctatcttggc attgttgttc cctcaagaac cgctgctcga    13440

gtttcctctg gtacgagata ttggtgctcg tgtaaaagat ccatttaccc tacaacctgc    13500

ggcgttttta caagagttag atttgagtgc tccggcaagg tatgacgcat tcacaatcag    13560

tcaggcgcat tctgaacaca tattgccaaa cccagaggaa gatcacttag tacgatactt    13620

gttcagagga atagggactg cgtcctcctc ttggtataag gcatcccatc ttctttctgt    13680

acccgaggtc agatgtgcaa ggcatgggaa ctccttatat ttagcagaag gaagtggagc    13740

catcatgagt cttctcgaat tgcatatacc acacgaaact atctattaca atacactttt    13800

ctcgaacgag atgaaccccc cacagcgaca tttcggacca actccaacac agtttctgaa    13860

ttcggttgtt tttaggaatt tacaggcgga agtaccatgc aaggatggat ttgtccagga    13920

gttccgtccg ttatggagag agaatacaga agaaagcgat ctgacctcag ataaagcagt    13980

gggatatatc acatctgtag tgccgtacag gtctgtatca ttgctgcatt gtgacattga    14040

aatccctcca ggatctaatc aaagcttact agatcagctg gctaccaatc tgtctctgat    14100

tgccatgcat tctgtgaagg agggcggggt cgtgattatc aaagtactgt atgcaatggg    14160

atattacttc catctactca tgaacttgtt tactccatgt tccacgaaag gatatattct    14220

ctctaatggc tatgcctgta gaggggatat ggagtgttac ctgatatttg tcatgggcta    14280

cctaggcggg cctacatttg tacatgaggt ggtgaggatg gcaaaaacgc tagtacagcg    14340

gcatggcaca cttttgtcta agtcagatga gattacactg actaggttat ttacttcaca    14400

gcaacagcgt gtaacagaca tcctatccag ccctttaccg agactaatga agtacttgag    14460

agagaatatt gatactgcac tgattgaagc cgggggacag cctgtccgtc cattctgtgc    14520

agagagttta gtgagcacac taacagacat gactcagaca acccagatca tcgccagcca    14580

cattgataca gtcattcgat ctgtgatcta tatggaagca gagggtgatc ttgctgacac    14640

agtattctta tttacccctt acaacctctc tatggacggg aaaaagagaa catcacttaa    14700

acagtgcaca agacagatct tagaggtcac aatactgggt ctcagagtca aaaatctcaa    14760

taaagtaggt gatgtaatca gcctagtact cagaggtatg atttctctgg aggaccttct    14820

cccactgaga acctacttga agtgtagtac ctgccctaag tatttgaagg ctgtcctagg    14880

tattaccaaa ctcaaagaaa tgttcacaga cgcctcttta ttatacttga ctcgtgctca    14940

acaaaaattc tacatgaaaa ctataggcaa tgcagtcaag ggatactata gtaactgtga    15000

ctcttaaagg caaccacata tcaataggcc ctctttctag ccgatcgtat tcttgttgac    15060

ttcattatac catattagaa aaaaattgaa ttccgaccct ttaagactcg tattcggatt    15120

caaataatta tctcagaaaa aaagtgcacg tagttgttct tgattatagt cccgtcattc    15180

accaagtctt tgtttggt                                                  15198




<210> 6
<211> 15186
<212> DNA
<213> Newcastle disease virus


<220> 
<223> Mut HN(F277L)/M(G165W)/F(F117S)/F(F190L)/F(L289A)/L(V757I)/L(F1551S)/L(R1700L)

<400> 6
accaaacaga gaatccgtga gatacgataa aaggcgaagg agcaatcgaa gtcgtacggg       60

tagaaggtgt gaatctcgag tgcgagaccg aagcttaaac tcgagagagc cttctgccaa      120

catgtcttcc gtatttgacg agtatgaaca gctcctcgcg gctcagactc gccctaatgg      180

agctcacgga ggaggagaga aggggagcac cttaaaagtt gaagtcccgg tattcactct      240

taacagtgac gacccagaag atagatggaa ctttgcagta ttctgtctta ggattgctgt      300

tagcgaagat gccaacaaac cactcagaca aggtgctctc atatctctct tatgctccca      360

ttctcaagtg atgaggaacc atgtcgccct tgcagggaaa cagaatgagg ccacactggc      420

tgttcttgag atcgatggtt tcaccaacag cgtgcctcaa tttaacaaca ggagtggagt      480

gtctgaggag agagcacaga gattcttgat gatagcaggg tccctccctc gggcatgcag      540

caacggtacc ccgttcatca cagctggggt tgaagatgat gcaccagaag acatcactga      600

tactctggaa agaatcatct ctatccaggc tcaagtatgg gtcacggtag caaaggccat      660

gactgcatat gagacagcgg atgagtcgga aacaagaaga atcaataagt atatgcagca      720

aggcagagtc caaaagaagt acatcctcca ccccgtatgt aggagcgcaa ttcaactcac      780

gattagacaa tctctggcag tccgcatttt cttggttagc gagcttaaga gaggccgcaa      840

cacggcaggt ggaagttcca cttattatag cttggtaggg gacatagact catacatcag      900

gaacaccggg cttactgcat tcttcctgac actcaggtat ggaattaaca ccaagacatc      960

agcccttgca ctcagcagcc tcgcaggcga tatccaaaaa atgaagcagc tcatgcgtct     1020

atatcggatg aaaggagata atgcgccgta catgacactg ctcggtgaca gtgaccagat     1080

gagctttgca ccggctgagt atgcacaact ctactctttt gcaatgggta tggcatccgt     1140

cctagacaaa ggaactggca agtaccagtt cgccagagac tttatgagca catcattctg     1200

gagacttgga gtagagtatg ctcgggctca gggaagcagc atcaatgagg atatggctgc     1260

cgagctaaag ctgaccccag cggcaaggag gggcctggca gctgctgccc aacgagcgtc     1320

cgaggagacc ggcagcatgg acattcccac tcaacaagct ggggtcctca cagggctcag     1380

cgacggaggc cctcaagccc cacaaggtgg actgaacagg tcgcaagggc aaccggacgc     1440

cggagatggg gagacccaat ttttagattt gatgagagca gtggcaaata gtatgagaga     1500

agcgccaaac tctgtgcaga acaccactca gcaggagcct ccatctactc ctgggccatc     1560

tcaagacaac gacaccgact ggggatactg accgacaaca ctcagcctgc ctccatcgaa     1620

ttatctcgat tcttctgcct gtaacctaac ccctggtcca cagtctcaca cggccaaacc     1680

cgcaaacgag cccccccctc tctccccccc cctccagcca cacggctcca accgcccaaa     1740

acaacacggg cacaactcga ctcactcata atctacacag agccgaagat cttagaaaaa     1800

aatacgggta gaagagagac attcagagat caggacaaat catcagggtc tccgctctcc     1860

cctctaccca gcagaccaga gtgaagatgg ccaccttcac ggatgcagag atcgacgatc     1920

tatttgaaac cagtggaact gtcattgaca gcataattac ggcccaaggc aacccagtag     1980

agactgttgg aaggagcgca atcccacaag gcaaaactaa agcattgagt gcagcatggg     2040

agaaacatgg aagcacccaa ccgccggccg gccaagacac ccctgatcga atggacagat     2100

cagacaaaca accatcccca cccgaacagg caaccacaca caacagcccg ccagccacat     2160

ccaccgacca gccccccacc caggccgcag gcgaagccgg tgacacacag ctcaagactg     2220

gagcaagcaa ctccctcctg tcgatgctcg acaagcttag caataaatcg tccaatgcta     2280

aaaagggccc acggtcgagt ccccaggaag ggcaccacca acctccgacc cagcagcaag     2340

ggagtcaaca gagccgcgga aacagtcagg agagatcgca aaaccaggtc aaggccgcct     2400

ctggagacca gggcacagac gcgaacacag catatcatgg acaatggaag gagtcacaac     2460

catcagctgg tgcaatccct catgctctcc ggtcagggca gagccaagcc aatactcctg     2520

catctgtgga tcatgtccag ctacctgtcg actttgtgca ggcgatgatg tctatgatgg     2580

aggcgatatc acagaaggta aataaagtcg actatcagct agaccttgtc tcaaagcaga     2640

catcctccat ccccatgatg cgatctgaaa tccaacagct gaaaacatcc gttgcggtca     2700

tggaagccaa cctgggcatg atgaagattc tggaccctgg ttgtgctaac gtttcatctt     2760

taagtgacct acgggcggtc gcccgctctc acccagtttt agtttcaggc cccggagacc     2820

catctcctta tgtgacacaa gggggtgaat tgatactcaa taaactctcg caaccagtgc     2880

aacatccttc tgagttgatt aaacctgcca cgataagcgg gcctgatata ggagtggaga     2940

aggacactgt ccgtgcattg atcacctcac gcccaatgca tccgagctct tcagctaagc     3000

tcctgagtaa gctggatgca gccgggtcga tagaagaaat taggaaaatc aaacgccttg     3060

cgctgaatgg ctgatcacta ctacaacccg caacgggttc ccgtttatct attgtcacaa     3120

ggaacccgcc ccgagccctc ctctataaac ccaagattca aggctccaag cgataacctt     3180

ctcccgcctc ttccatccca ctgaatgatc gcgcagctgc aattaatcta gcaacattaa     3240

agattaagaa aaaatacggg tagaatcgga gtgcaccgat tgtgccaaga tggactcatc     3300

taggacaatt gggttatact ttgattctgc ccttccttct agcaacctgt tagcattccc     3360

gattgtctta cgagatgtag gagatggaaa gaagcaaatt actccgcaat ataggatccg     3420

gcgtcttgac tcgtggacag acagtaaaga agactcggta ttcatcacta cctacggatt     3480

catcttccag gttgggaatg aagaagtcac tgtcggcatg atcaatgata atcccaagcg     3540

agagttactc tccgctgcga tgctctgcct aggaagcgtc ccgaatgttg gagatcctgt     3600

tgagctggca agggcctgcc tcactatggt ggtaacatgc aagaagagtg caactaatac     3660

tgagagaatg gtcttctcag tagtgcaggc accccgggtg ctgcaaagct gtagggtcgt     3720

ggcagacaaa tactcgtcag tgaatgcagt taagcacgtg aaagcaccag agaagatccc     3780

ttggagtgaa accctagagt acaaggtgaa ttttgtctct ttgactgtgg tgccgaagaa     3840

ggatgtctac aagatcccaa ccgcagtatt gaaggtatcc ggctcgagcc tgtataatct     3900

tgcgctcaat gtcactattg atgtggaggt agacccaaag agcccgttag tcaagtccct     3960

ttctaggtcc gacagtggat actatgctaa tctcttctta catatcggac ttatgtccac     4020

tgtagataag aggggaaaga aagtgacatt tgaccagctg gagaggaaga taaggagact     4080

tgatctatct gtcgggctca gtgatgtgct cggaccttct gtgcttgtga aggcgagagg     4140

tgcacggact aggctgctgg cacctttctt ctctaacagc gggacagcct gctaccctat     4200

agcaaatgcc tctcctcagg tagctaagat actctggagt cagaccgcgt gcctgcggag     4260

tgtaaaaatc attattcaag cgggcaccca acgcgctgtc gcagtgactg ctgaccatga     4320

ggttacctct actaagatag agaagaggca taccatcgct aaatacaatc ccttcaagaa     4380

ataggccgta tccctgagac tgcaattcac ccgccttccc aaaacaccat gacaccagat     4440

aatgatctgt cttgattact tacagttagt ttccctgtct atcaaattag aaaaaacacg     4500

ggtagaagag ttcggatccc ggccggcgca ccaaaagcgc aagatgggcc ccagatcttc     4560

taccaggatc ccagtacctc taatgctgac catacggatc acgctggcac tgagttatgt     4620

ccgtctgaca agttctcttg atggcaggcc tcttgcagcc gcagggatcg tggtaacagg     4680

ggataaagca gttaacatat acacctcatc ccagacaggg tcaatcatag tcaagttact     4740

cccaaatatg cccaaggaca aagaggcatg tgcaaaagcc ccattggagg cttacaacag     4800

gacactgact actttgctta ccccccttgg tgattctatc cgcaggatac aagagtctgt     4860

gactacatcc ggaggaagga gacagagacg ctctataggt gccattattg gcagtgtagc     4920

tctaggggtt gcaacagctg cacagataac ggcagcctcg gctctgatac aagccaacca     4980

gaatgctgct aacatcctcc ggcttaagga gagcattgct gcaaccaatg aagctgtaca     5040

cgaggtcact ggcggattgt cacagttagc agtggcagtt ggaaagatgc agcaatttgt     5100

taatgaccag cttaataaca cagctcaaga gttggactgt ataaaaatta cacagcaggt     5160

tggtgtagaa ctcaacttat acttaactga attgactaca gtgttcgggc cacaaatcac     5220

ttcccctgcc ttaactcagt tgactgttca ggctctttac aatctggctg gtggtaatgt     5280

agattacttg ttgactaagt taggtgtagg gaacaaccag ctcagctcat tgattggtag     5340

cggcttgatc accggtaacc ctatttttta cgactcacag actcaactct tgggcataca     5400

ggtgactgca ccctcagtcg ggaacctaaa taatatgcgt gccacctact tggagacctt     5460

gtctgtaagc acaacaaagg gatttgcctc agcacttgtc ccaaaagtag tgacacaggt     5520

cggttctgtg atagaagagc ttgacacctc atactgtata gaagctgatt tggatttata     5580

ttgtacaaga atagtgacat tccctatgtc ccctggtatt tattcctgtt tgagcggcaa     5640

tacatcggct tgcatgtatt caaggactga aggcgcactt actacaccat acatgactct     5700

caaaggctca gttgttgcca attgccagat gacaacatgt agatgtgcag accccccggg     5760

tatcatatca caaaattatg gagaggctgt gtctctaata gataagcact catgcaatgt     5820

cgtatcctta gacgggataa ctttgaggct cagtggggaa tttgatgcaa cttatcaaaa     5880

gaatatctca atattagatt ctcaagtact agtgacaggc aatctcgata tctcaactga     5940

gcttgggaat gtcaaccact caataagtaa tgctttggat aagttagagg aaagcaacag     6000

caaactagac aaagtcaatg tcaaactgac cagcacatct gctctcatta cctatattgt     6060

tttaactgtc atatctcttg ttcttggtat gcttagcctg gttctagcat gctatctgat     6120

gtacaagcaa aaagcgcaac gaaagacctt gttgtggctt ggaaataata ccctagatca     6180

gatgagagct actacaaaaa tgtgaatgca gatgagaggc agaggtatcc ccaatagcaa     6240

tctgtgtgtc aattctggca gcctgttaat cagaagaatt aagaaaaaac taccggatgt     6300

aggtgaacaa aagggaatat acgggtagaa cggcctgaga ggccacccct caatcgggag     6360

ccaggcccca ctacgtccgc tctaccgcat caccaacagc agtcttcagt catggacagc     6420

gcagttagcc aagttgcgct agagaatgat agaagagaag cgaataatac atggcgcttg     6480

gttttccgga tcgcagcctt acttttactg gtaataacct tagccgtctc tgcagtcgcc     6540

ctggcatata gtatggaggc tagcacacct ggcgaccttg taagcatacc gactgcgatc     6600

tctagggcag aggaaaggat tacatctgca ctcggttcca atcaagatgt agtagatagg     6660

atatacaagc aagtggccct tgagtctcca ttggcactgc taaataccga atctataatt     6720

atgaatgcaa taacgtctct ctcttatcaa atcaatggag ccacaaataa tagcgggtgt     6780

ggggcacctg ttcatgaccc agattacatc ggggggatag gtcaagaact tattgtagat     6840

gatacgagtg acgtcacatc attttatccc tctgcattcc aagaacacct gaattttatc     6900

ccggcgccca ctacaggatc aggctgcact cggataccct cattcgacat gagtgctacc     6960

cattactgtt acactcacaa tgtgatattg tctggctgca gagatcactc acactcacat     7020

cagtatttag cacttggtgt gcttcggaca tctgcaacag ggagggtatt cttttctact     7080

ctgcgttcca tcaacttgga tgacgcccaa aatcggaagt cttgcagtgt gagtgcaact     7140

cctttaggtt gtgatatgct gtgctctaaa atcacagaga ctgaggaaga ggattataaa     7200

tcagttatcc ccacatcgat ggtacatgga aggttagggc ttgacggcca ataccatgag     7260

aaggacctag acgtcacaac actatttagg gactgggtgg caaattaccc aggagtagga     7320

ggtgggtctt ttattaacaa tcgcgtatgg ttcccggtct acggagggct aaaacccagc     7380

tcgcctagtg acactgcaca agaagggaga tacgtaatat acaagcgata caatgacaca     7440

tgcccggatg agcaagatta ccagattcgg atggctaagt catcgtataa gcctaggcgg     7500

tttggtggaa aacgcgtaca gcaggccatc ctatccatca aggtgtcaac atccttgggt     7560

gaggacccgg tgttgactgt accgcctaat acggtcgcac tcatgggggc cgaaggcaga     7620

gttctcacag tggggacatc tcatttctta tatcagcgag ggtcatcata cttctctccc     7680

gctttgttat accctatgac agtcaacaac aaaacagcca ctcttcataa tccttataca     7740

ttcaatgctt tcactcggcc aggtagtgtc ccttgccagg cttcagcaag atgccccaac     7800

tcatgtgtta ccggagtcta tactgatcca tatcccttag tcttccatag gaaccacacc     7860

ttgcgagggg tattcggaac aatgcttgat gacgaacaag caagactcaa ccctgtatct     7920

gcagtatttg ataacatatc ccgcagtcgc ataactcggg taagttcaag cagtaccagg     7980

gcagcataca cgacatcaac gtgttttaaa gttgtcaaga ccaataaaac ctattgcctc     8040

agcattgcag aaatatccaa taccctcttc ggggaattca gaattgtccc cttactagtt     8100

gagattctca aggatggtgg ggtttaagaa gctaggaatg gtcggttgag tcaaccgtga     8160

gaaggcgggg aagatgatat tgcatcatct atcttctgta acaccaagaa tcaaatcgaa     8220

taccagtgcg agctcgaatc ctacgctgcc agtcagccat aatcggctgg tgctaatgtg     8280

gttagcctga atcttgtcga tagtcacttg attaagaaaa aatgtggacg gtagtgaaat     8340

ataaggcaaa gcagctcaca gaggacagca cgggtaggac atggcgggct ccggacccga     8400

aagggcagag catcagatta tcctaccaga gtcacatctg tcctcaccat tggtcaagca     8460

taaattgctt tattactgga aattaactgg gctaccgctt cctgacgaat gtgacttcga     8520

ccatcttatt atcagccgac aatggaagaa ggtacttgaa tcggccaccc ctgacattga     8580

gagaatgata aaactagggc gggcagtaca ccagactctc aaccacaatt ccaggataac     8640

cggagtactc catccccggt gtttagagga actggctagt attgaggttc ctgattcaac     8700

caacaaattt cggaagatcg aaaaaaagat ccagattcac aacacaaggt atggagaact     8760

gttcacaaga ttatgcacgc atgtagaaaa gaaactattg gggtcatctt ggtctaacaa     8820

tgtcccacgg tcagaggaat tcaacagcat ccgtacagat ccggcatttt ggtttcactc     8880

aaaatggtcc acagccaaat ttgcatggct ccatataaaa caggtccaga ggcatctgat     8940

tgtagcagca agaacaaggt ccgcagtcaa caaattagtg acgctgaccc ataaggtagg     9000

ccaaatcttt gttactcctg agcttgtcat tgtgacacat acagatgaga acaagttcac     9060

gtgtcttacc caggaacttg tgttgatgta tgcagatatg atggagggca gagatatggt     9120

cagcataata tcatccacgg cggcacatct taggagctta tcagagaaaa ttgatgatat     9180

tctgcggtta gtagatgctc tggcaagaga tttgggcaat caagtctacg atgttgtagc     9240

actaatggag ggattcgcat acggcgctgt tcagctgctt gaaccgtcag gtacatttgc     9300

gggggatttc ttcgcattca acctgcagga gctcaaagat actctaaccg gactcctccc     9360

caaggatatc gcagaatctg tgactcacgc aatcgcaacc atattctctg gcttagaaca     9420

aaatcaagca gctgagatgt tgtgcctgtt gcgtctgtgg ggtcacccac tactcgagtc     9480

ccgtattgca gcaaaagcag ttaggagtca aatgtgcgca ccaaaaatgg tagactttga     9540

tatgatcctc caggtattat ctttctttaa aggaacaatc atcaatggat atagaaagaa     9600

gaatgcaggc gtgtggccac gtgtcaagat agatacgata tacgggaagg tcatagggca     9660

gctacacgca gattctgcag agatttcaca tgatgtcatg ttgagggaat acaagagttt     9720

atctgcactt gaattcgagc catgtataga gtatgaccct gtcaccaatc tgagcatgtt     9780

tttaaaagac aaggcaatcg cacacccgaa agacaactgg ctcgcttcgt ttaggcgaaa     9840

ccttctctct gaggaccaga agaaacatgt aagagaggca acctcaacta accgcctctt     9900

gatagagttc ttagagtcaa atgattttga tccatataaa gagatggaat atctgacgac     9960

ccttgagtac ctaagagatg ataatgtggc agtatcatac tcactcaaag aaaaagaggt    10020

gaaagttaat gggcggattt tcgcaaagct aacaaataga ttaaggaatt gtcaggtaat    10080

ggcagaaggg atcctagctg accagattgc acctttcttc cagggaaatg gggtcattca    10140

ggatagcata tctttgacta aaagtatgct agcgatgagt caactgtctt tcaacagcaa    10200

caagaaacgt attactgact gcaaagaaag agtatcctca aaccgcaatc atgatccgaa    10260

gagcaagaat cgtcggagag ttgccacttt tgtaactacc gacctgcaaa agtattgtct    10320

caattggaga tatcagacag tcaagctgtt cgctcatgcc atcaatcagc tgatgggctt    10380

acctcacttc ttcgagtgga ttcatcttag actaatggat actacgatgt ttgtagggga    10440

ccctttcaat cctccaagtg accctacgga ctgtgatcta tcaagagtcc caaatgatga    10500

catatatatt gtcagtgcta ggggaggcat tgagggatta tgccagaagc tatggacaat    10560

gatctcaatt gctgcaatcc agcttgctgc agcaagatca cattgtcgcg ttgcctgtat    10620

ggtacaaggc gacaatcaag taatagctat aacgagagag gtaagatcag atgactcccc    10680

agagatggtg ttaacacaat tgcatcaagc cagtgataat ttcttcaagg aattgattca    10740

tgtcaatcat ttgatcggcc ataatttgaa ggatcgtgaa accatcaggt cagacacgtt    10800

cttcatatac agcaaacgaa tattcaaaga tggagcaata ctcagtcagg tcctcaaaaa    10860

ctcatctaaa ttagtgctaa tatcaggcga ccttagtgaa aacactgtaa tgtcttgtgc    10920

caacattgca tctactgtag cacggttatg cgagaacggg cttcctaagg atttctgtta    10980

ttacttaaac tacttaatga gttgcgtgca gacatacttc gattccgaat tttccatcac    11040

caacaactcg caactcgatt ctaaccagtc gtggatagag gacatttctt ttgtgcactc    11100

atatgtcctg acccctgctc aactgggggg actgagtaac cttcaatact caaggctcta    11160

cacaaggaac atcggcgacc cgggaaccac tgctttcgca gagatcaaga gattagaggc    11220

agtggggtta ctgagtccta gcattatgac taacatctta actaggccgc ctggaaatgg    11280

agattgggcc agtctgtgca acgatccata ctcctttaat tttgagactg tcgcaagccc    11340

aaatattgtc cttaagaaac atacacaaag agtcctattt gaaacttgct cgaatccctt    11400

attatctgga gtgcacacag aggataatga ggcagaagag aaggcattgg ctgaattctt    11460

gctcaatcaa gaaatgattc atccacgtgt cgcgcatgct atcatggaag caagctctgt    11520

aggtaggaga aagcaaattc aggggcttgt tgacacaaca aacaccgtga ttaagattgc    11580

actgactagg aggccactcg gcatcaagag gctgatgcgg atagtcaatt actcgagcat    11640

gcatgcaatg ctatttagag atgatgtttt ctcgtctaat agatccaacc atcccttagt    11700

ctcttctgat atgtgttctc agacactggc agactatgca cggaacagaa gctggtcacc    11760

tttgacaggg ggtagaaaaa tactgggtgt atctaatcct gataccatag aacttgtaga    11820

gggtgagatc cttagtgtca gtggagggtg cactagatgt gacagtgggg atgaacagtt    11880

tacttggttc catcttccaa gcaatataga gctaaacgat gacaccagca agaatcctcc    11940

aatgagagtg ccatatctcg ggtcaaagac tcaagagagg agagccgcct cgcttgcgaa    12000

aatagctcat atgtcaccac acgtgaaggc ggctctaagg gcgtcatctg tgttaatctg    12060

ggcttatggg gacaacgaaa taaactggac tgctgccctt aagattgcaa ggtctcggtg    12120

caacataagc tcagagtatc ttcgactatt gtcacccttg cctacagctg ggaatctcca    12180

acatagattg gacgacggca taactcagat gacattcacc cctgcatctc tatacagggt    12240

gtcaccttac attcatatat ctaatgattc tcaaaggcta tttactgaag aaggagtcaa    12300

agaggggaat gtggtttatc agcaaatcat gctcttgggt ttgtccttaa ttgagtcact    12360

cttcccaatg acaacaacca agacatatga tgaaatcaca ttgcacctcc acagtaaatt    12420

tagctgctgt atcagggaag cacctgttgc agttcctttc gagctactcg gggtggcacc    12480

ggaactaagg gcagtaacct caaataagtt tatgtatgat cctagccctg tatcagaggg    12540

agactttgcg agacttgact tagctatctt taagagttat gaacttaatt tagagtcata    12600

ttccacaata gagctaatga acgttctttc aatatctagt gggaagttga ttggccagtc    12660

tgtggtttct tatgatgaag atacctccat aaagaatgac gctataatag tgtatgacaa    12720

cacacggaat tggatcagcg aagctcagaa ttcagatgtg gtccgcctat tcgagtatgc    12780

ggcactcgaa gtgctcctcg actgttctta tcaactctac tatctgagag taagaggcct    12840

aaacaatatc gtcctgtaca tgagtgattt atacaagaat atgccaggaa ttctactctc    12900

taatattgca gccacaatat ctcaccctgt catccattca aggttgaatg cagtaggtct    12960

ggtcaaccat gacgggtcac accaacttgc agacacagat ttcattgaaa tgtctgcaaa    13020

gctgctagtc tcttgcactc gacgcgtggt ctcaggttta catgcaggga ataagtatga    13080

cctgctgttt ccatctgtct tggatgataa cctaagtgag aagatgcttc agttgatatc    13140

ccaattatgc tgtctgtata cggtgctctt tgctacaaca agagaaatcc cgaaaataag    13200

aggcttatct gcagaagaga aatgttcagt acttactgag tacctactgt cagatgctgt    13260

gaaaccgtta cttgggtccg agcaagtgag ctctatcatg tctcccaaca tagttacgtt    13320

cccagccaat ctgtattaca tgtctaggaa gagccttaat ttgatcaggg agagagagga    13380

cagggatact atcttggcat tgttgttccc tcaagaaccg ctgctcgagt ttcctctggt    13440

acgagatatt ggtgctcgtg taaaagatcc atttacccta caacctgcgg cgtttttaca    13500

agagttagat ttgagtgctc cggcaaggta tgacgcattc acaatcagtc aggcgcattc    13560

tgaacacata ttgccaaacc cagaggaaga tcacttagta cgatacttgt tcagaggaat    13620

agggactgcg tcctcctctt ggtataaggc atcccatctt ctttctgtac ccgaggtcag    13680

atgtgcaagg catgggaact ccttatattt agcagaagga agtggagcca tcatgagtct    13740

tctcgaattg catataccac acgaaactat ctattacaat acacttttct cgaacgagat    13800

gaacccccca cagcgacatt tcggaccaac tccaacacag tttctgaatt cggttgtttt    13860

taggaattta caggcggaag taccatgcaa ggatggattt gtccaggagt tccgtccgtt    13920

atggagagag aatacagaag aaagcgatct gacctcagat aaagcagtgg gatatatcac    13980

atctgtagtg ccgtacaggt ctgtatcatt gctgcattgt gacattgaaa tccctccagg    14040

atctaatcaa agcttactag atcagctggc taccaatctg tctctgattg ccatgcattc    14100

tgtgaaggag ggcggggtcg tgattatcaa agtactgtat gcaatgggat attacttcca    14160

tctactcatg aacttgttta ctccatgttc cacgaaagga tatattctct ctaatggcta    14220

tgcctgtaga ggggatatgg agtgttacct gatatttgtc atgggctacc taggcgggcc    14280

tacatttgta catgaggtgg tgaggatggc aaaaacgcta gtacagcggc atggcacact    14340

tttgtctaag tcagatgaga ttacactgac taggttattt acttcacagc aacagcgtgt    14400

aacagacatc ctatccagcc ctttaccgag actaatgaag tacttgagag agaatattga    14460

tactgcactg attgaagccg ggggacagcc tgtccgtcca ttctgtgcag agagtttagt    14520

gagcacacta acagacatga ctcagacaac ccagatcatc gccagccaca ttgatacagt    14580

cattcgatct gtgatctata tggaagcaga gggtgatctt gctgacacag tattcttatt    14640

taccccttac aacctctcta tggacgggaa aaagagaaca tcacttaaac agtgcacaag    14700

acagatctta gaggtcacaa tactgggtct cagagtcaaa aatctcaata aagtaggtga    14760

tgtaatcagc ctagtactca gaggtatgat ttctctggag gaccttctcc cactgagaac    14820

ctacttgaag tgtagtacct gccctaagta tttgaaggct gtcctaggta ttaccaaact    14880

caaagaaatg ttcacagacg cctctttatt atacttgact cgtgctcaac aaaaattcta    14940

catgaaaact ataggcaatg cagtcaaggg atactatagt aactgtgact cttaaaggca    15000

accacatatc aataggccct ctttctagcc gatcgtattc ttgttgactt cattatacca    15060

tattagaaaa aaattgaatt ccgacccttt aagactcgta ttcggattca aataattatc    15120

tcagaaaaaa agtgcacgta gttgttcttg attatagtcc cgtcattcac caagtctttg    15180

tttggt                                                               15186




<210> 7
<211> 15198
<212> DNA
<213> Newcastle disease virus


<220> 
<223> Mut HN(F277L)/M(G165W)/F(F117S)/F(F190L)/F(L289A)/L(V757I)/L(F1551S)/L(R1700L)+AfeI

<400> 7
accaaacaga gaatccgtga gatacgataa aaggcgaagg agcaatcgaa gtcgtacggg       60

tagaaggtgt gaatctcgag tgcgagaccg aagcttaaac tcgagagagc cttctgccaa      120

catgtcttcc gtatttgacg agtatgaaca gctcctcgcg gctcagactc gccctaatgg      180

agctcacgga ggaggagaga aggggagcac cttaaaagtt gaagtcccgg tattcactct      240

taacagtgac gacccagaag atagatggaa ctttgcagta ttctgtctta ggattgctgt      300

tagcgaagat gccaacaaac cactcagaca aggtgctctc atatctctct tatgctccca      360

ttctcaagtg atgaggaacc atgtcgccct tgcagggaaa cagaatgagg ccacactggc      420

tgttcttgag atcgatggtt tcaccaacag cgtgcctcaa tttaacaaca ggagtggagt      480

gtctgaggag agagcacaga gattcttgat gatagcaggg tccctccctc gggcatgcag      540

caacggtacc ccgttcatca cagctggggt tgaagatgat gcaccagaag acatcactga      600

tactctggaa agaatcatct ctatccaggc tcaagtatgg gtcacggtag caaaggccat      660

gactgcatat gagacagcgg atgagtcgga aacaagaaga atcaataagt atatgcagca      720

aggcagagtc caaaagaagt acatcctcca ccccgtatgt aggagcgcaa ttcaactcac      780

gattagacaa tctctggcag tccgcatttt cttggttagc gagcttaaga gaggccgcaa      840

cacggcaggt ggaagttcca cttattatag cttggtaggg gacatagact catacatcag      900

gaacaccggg cttactgcat tcttcctgac actcaggtat ggaattaaca ccaagacatc      960

agcccttgca ctcagcagcc tcgcaggcga tatccaaaaa atgaagcagc tcatgcgtct     1020

atatcggatg aaaggagata atgcgccgta catgacactg ctcggtgaca gtgaccagat     1080

gagctttgca ccggctgagt atgcacaact ctactctttt gcaatgggta tggcatccgt     1140

cctagacaaa ggaactggca agtaccagtt cgccagagac tttatgagca catcattctg     1200

gagacttgga gtagagtatg ctcgggctca gggaagcagc atcaatgagg atatggctgc     1260

cgagctaaag ctgaccccag cggcaaggag gggcctggca gctgctgccc aacgagcgtc     1320

cgaggagacc ggcagcatgg acattcccac tcaacaagct ggggtcctca cagggctcag     1380

cgacggaggc cctcaagccc cacaaggtgg actgaacagg tcgcaagggc aaccggacgc     1440

cggagatggg gagacccaat ttttagattt gatgagagca gtggcaaata gtatgagaga     1500

agcgccaaac tctgtgcaga acaccactca gcaggagcct ccatctactc ctgggccatc     1560

tcaagacaac gacaccgact ggggatactg accgacaaca ctcagcctgc ctccatcgaa     1620

ttatctcgat tcttctgcct gtaacctaac ccctggtcca cagtctcaca cggccaaacc     1680

cgcaaacgag cccccccctc tctccccccc cctccagcca cacggctcca accgcccaaa     1740

acaacacggg cacaactcga ctcactcata atctacacag agccgaagat cttagaaaaa     1800

aatacgggta gaagagagac attcagagat caggacaaat catcagggtc tccgctctcc     1860

cctctaccca gcagaccaga gtgaagatgg ccaccttcac ggatgcagag atcgacgatc     1920

tatttgaaac cagtggaact gtcattgaca gcataattac ggcccaaggc aacccagtag     1980

agactgttgg aaggagcgca atcccacaag gcaaaactaa agcattgagt gcagcatggg     2040

agaaacatgg aagcacccaa ccgccggccg gccaagacac ccctgatcga atggacagat     2100

cagacaaaca accatcccca cccgaacagg caaccacaca caacagcccg ccagccacat     2160

ccaccgacca gccccccacc caggccgcag gcgaagccgg tgacacacag ctcaagactg     2220

gagcaagcaa ctccctcctg tcgatgctcg acaagcttag caataaatcg tccaatgcta     2280

aaaagggccc acggtcgagt ccccaggaag ggcaccacca acctccgacc cagcagcaag     2340

ggagtcaaca gagccgcgga aacagtcagg agagatcgca aaaccaggtc aaggccgcct     2400

ctggagacca gggcacagac gcgaacacag catatcatgg acaatggaag gagtcacaac     2460

catcagctgg tgcaatccct catgctctcc ggtcagggca gagccaagcc aatactcctg     2520

catctgtgga tcatgtccag ctacctgtcg actttgtgca ggcgatgatg tctatgatgg     2580

aggcgatatc acagaaggta aataaagtcg actatcagct agaccttgtc tcaaagcaga     2640

catcctccat ccccatgatg cgatctgaaa tccaacagct gaaaacatcc gttgcggtca     2700

tggaagccaa cctgggcatg atgaagattc tggaccctgg ttgtgctaac gtttcatctt     2760

taagtgacct acgggcggtc gcccgctctc acccagtttt agtttcaggc cccggagacc     2820

catctcctta tgtgacacaa gggggtgaat tgatactcaa taaactctcg caaccagtgc     2880

aacatccttc tgagttgatt aaacctgcca cgataagcgg gcctgatata ggagtggaga     2940

aggacactgt ccgtgcattg atcacctcac gcccaatgca tccgagctct tcagctaagc     3000

tcctgagtaa gctggatgca gccgggtcga tagaagaaat taggaaaatc aaacgccttg     3060

cgctgaatgg ctgatcacta ctacaacccg caacgggttc ccgtttatct attgtcacaa     3120

ggaacccgcc ccgaagcgct gaccgagccc tcctctataa acccaagatt caaggctcca     3180

agcgataacc ttctcccgcc tcttccatcc cactgaatga tcgcgcagct gcaattaatc     3240

tagcaacatt aaagattaag aaaaaatacg ggtagaatcg gagtgcaccg attgtgccaa     3300

gatggactca tctaggacaa ttgggttata ctttgattct gcccttcctt ctagcaacct     3360

gttagcattc ccgattgtct tacgagatgt aggagatgga aagaagcaaa ttactccgca     3420

atataggatc cggcgtcttg actcgtggac agacagtaaa gaagactcgg tattcatcac     3480

tacctacgga ttcatcttcc aggttgggaa tgaagaagtc actgtcggca tgatcaatga     3540

taatcccaag cgagagttac tctccgctgc gatgctctgc ctaggaagcg tcccgaatgt     3600

tggagatcct gttgagctgg caagggcctg cctcactatg gtggtaacat gcaagaagag     3660

tgcaactaat actgagagaa tggtcttctc agtagtgcag gcaccccggg tgctgcaaag     3720

ctgtagggtc gtggcagaca aatactcgtc agtgaatgca gttaagcacg tgaaagcacc     3780

agagaagatc ccttggagtg aaaccctaga gtacaaggtg aattttgtct ctttgactgt     3840

ggtgccgaag aaggatgtct acaagatccc aaccgcagta ttgaaggtat ccggctcgag     3900

cctgtataat cttgcgctca atgtcactat tgatgtggag gtagacccaa agagcccgtt     3960

agtcaagtcc ctttctaggt ccgacagtgg atactatgct aatctcttct tacatatcgg     4020

acttatgtcc actgtagata agaggggaaa gaaagtgaca tttgaccagc tggagaggaa     4080

gataaggaga cttgatctat ctgtcgggct cagtgatgtg ctcggacctt ctgtgcttgt     4140

gaaggcgaga ggtgcacgga ctaggctgct ggcacctttc ttctctaaca gcgggacagc     4200

ctgctaccct atagcaaatg cctctcctca ggtagctaag atactctgga gtcagaccgc     4260

gtgcctgcgg agtgtaaaaa tcattattca agcgggcacc caacgcgctg tcgcagtgac     4320

tgctgaccat gaggttacct ctactaagat agagaagagg cataccatcg ctaaatacaa     4380

tcccttcaag aaataggccg tatccctgag actgcaattc acccgccttc ccaaaacacc     4440

atgacaccag ataatgatct gtcttgatta cttacagtta gtttccctgt ctatcaaatt     4500

agaaaaaaca cgggtagaag agttcggatc ccggccggcg caccaaaagc gcaagatggg     4560

ccccagatct tctaccagga tcccagtacc tctaatgctg accatacgga tcacgctggc     4620

actgagttat gtccgtctga caagttctct tgatggcagg cctcttgcag ccgcagggat     4680

cgtggtaaca ggggataaag cagttaacat atacacctca tcccagacag ggtcaatcat     4740

agtcaagtta ctcccaaata tgcccaagga caaagaggca tgtgcaaaag ccccattgga     4800

ggcttacaac aggacactga ctactttgct tacccccctt ggtgattcta tccgcaggat     4860

acaagagtct gtgactacat ccggaggaag gagacagaga cgctctatag gtgccattat     4920

tggcagtgta gctctagggg ttgcaacagc tgcacagata acggcagcct cggctctgat     4980

acaagccaac cagaatgctg ctaacatcct ccggcttaag gagagcattg ctgcaaccaa     5040

tgaagctgta cacgaggtca ctggcggatt gtcacagtta gcagtggcag ttggaaagat     5100

gcagcaattt gttaatgacc agcttaataa cacagctcaa gagttggact gtataaaaat     5160

tacacagcag gttggtgtag aactcaactt atacttaact gaattgacta cagtgttcgg     5220

gccacaaatc acttcccctg ccttaactca gttgactgtt caggctcttt acaatctggc     5280

tggtggtaat gtagattact tgttgactaa gttaggtgta gggaacaacc agctcagctc     5340

attgattggt agcggcttga tcaccggtaa ccctattttt tacgactcac agactcaact     5400

cttgggcata caggtgactg caccctcagt cgggaaccta aataatatgc gtgccaccta     5460

cttggagacc ttgtctgtaa gcacaacaaa gggatttgcc tcagcacttg tcccaaaagt     5520

agtgacacag gtcggttctg tgatagaaga gcttgacacc tcatactgta tagaagctga     5580

tttggattta tattgtacaa gaatagtgac attccctatg tcccctggta tttattcctg     5640

tttgagcggc aatacatcgg cttgcatgta ttcaaggact gaaggcgcac ttactacacc     5700

atacatgact ctcaaaggct cagttgttgc caattgccag atgacaacat gtagatgtgc     5760

agaccccccg ggtatcatat cacaaaatta tggagaggct gtgtctctaa tagataagca     5820

ctcatgcaat gtcgtatcct tagacgggat aactttgagg ctcagtgggg aatttgatgc     5880

aacttatcaa aagaatatct caatattaga ttctcaagta ctagtgacag gcaatctcga     5940

tatctcaact gagcttggga atgtcaacca ctcaataagt aatgctttgg ataagttaga     6000

ggaaagcaac agcaaactag acaaagtcaa tgtcaaactg accagcacat ctgctctcat     6060

tacctatatt gttttaactg tcatatctct tgttcttggt atgcttagcc tggttctagc     6120

atgctatctg atgtacaagc aaaaagcgca acgaaagacc ttgttgtggc ttggaaataa     6180

taccctagat cagatgagag ctactacaaa aatgtgaatg cagatgagag gcagaggtat     6240

ccccaatagc aatctgtgtg tcaattctgg cagcctgtta atcagaagaa ttaagaaaaa     6300

actaccggat gtaggtgaac aaaagggaat atacgggtag aacggcctga gaggccaccc     6360

ctcaatcggg agccaggccc cactacgtcc gctctaccgc atcaccaaca gcagtcttca     6420

gtcatggaca gcgcagttag ccaagttgcg ctagagaatg atagaagaga agcgaataat     6480

acatggcgct tggttttccg gatcgcagcc ttacttttac tggtaataac cttagccgtc     6540

tctgcagtcg ccctggcata tagtatggag gctagcacac ctggcgacct tgtaagcata     6600

ccgactgcga tctctagggc agaggaaagg attacatctg cactcggttc caatcaagat     6660

gtagtagata ggatatacaa gcaagtggcc cttgagtctc cattggcact gctaaatacc     6720

gaatctataa ttatgaatgc aataacgtct ctctcttatc aaatcaatgg agccacaaat     6780

aatagcgggt gtggggcacc tgttcatgac ccagattaca tcggggggat aggtcaagaa     6840

cttattgtag atgatacgag tgacgtcaca tcattttatc cctctgcatt ccaagaacac     6900

ctgaatttta tcccggcgcc cactacagga tcaggctgca ctcggatacc ctcattcgac     6960

atgagtgcta cccattactg ttacactcac aatgtgatat tgtctggctg cagagatcac     7020

tcacactcac atcagtattt agcacttggt gtgcttcgga catctgcaac agggagggta     7080

ttcttttcta ctctgcgttc catcaacttg gatgacgccc aaaatcggaa gtcttgcagt     7140

gtgagtgcaa ctcctttagg ttgtgatatg ctgtgctcta aaatcacaga gactgaggaa     7200

gaggattata aatcagttat ccccacatcg atggtacatg gaaggttagg gcttgacggc     7260

caataccatg agaaggacct agacgtcaca acactattta gggactgggt ggcaaattac     7320

ccaggagtag gaggtgggtc ttttattaac aatcgcgtat ggttcccggt ctacggaggg     7380

ctaaaaccca gctcgcctag tgacactgca caagaaggga gatacgtaat atacaagcga     7440

tacaatgaca catgcccgga tgagcaagat taccagattc ggatggctaa gtcatcgtat     7500

aagcctaggc ggtttggtgg aaaacgcgta cagcaggcca tcctatccat caaggtgtca     7560

acatccttgg gtgaggaccc ggtgttgact gtaccgccta atacggtcgc actcatgggg     7620

gccgaaggca gagttctcac agtggggaca tctcatttct tatatcagcg agggtcatca     7680

tacttctctc ccgctttgtt ataccctatg acagtcaaca acaaaacagc cactcttcat     7740

aatccttata cattcaatgc tttcactcgg ccaggtagtg tcccttgcca ggcttcagca     7800

agatgcccca actcatgtgt taccggagtc tatactgatc catatccctt agtcttccat     7860

aggaaccaca ccttgcgagg ggtattcgga acaatgcttg atgacgaaca agcaagactc     7920

aaccctgtat ctgcagtatt tgataacata tcccgcagtc gcataactcg ggtaagttca     7980

agcagtacca gggcagcata cacgacatca acgtgtttta aagttgtcaa gaccaataaa     8040

acctattgcc tcagcattgc agaaatatcc aataccctct tcggggaatt cagaattgtc     8100

cccttactag ttgagattct caaggatggt ggggtttaag aagctaggaa tggtcggttg     8160

agtcaaccgt gagaaggcgg ggaagatgat attgcatcat ctatcttctg taacaccaag     8220

aatcaaatcg aataccagtg cgagctcgaa tcctacgctg ccagtcagcc ataatcggct     8280

ggtgctaatg tggttagcct gaatcttgtc gatagtcact tgattaagaa aaaatgtgga     8340

cggtagtgaa atataaggca aagcagctca cagaggacag cacgggtagg acatggcggg     8400

ctccggaccc gaaagggcag agcatcagat tatcctacca gagtcacatc tgtcctcacc     8460

attggtcaag cataaattgc tttattactg gaaattaact gggctaccgc ttcctgacga     8520

atgtgacttc gaccatctta ttatcagccg acaatggaag aaggtacttg aatcggccac     8580

ccctgacatt gagagaatga taaaactagg gcgggcagta caccagactc tcaaccacaa     8640

ttccaggata accggagtac tccatccccg gtgtttagag gaactggcta gtattgaggt     8700

tcctgattca accaacaaat ttcggaagat cgaaaaaaag atccagattc acaacacaag     8760

gtatggagaa ctgttcacaa gattatgcac gcatgtagaa aagaaactat tggggtcatc     8820

ttggtctaac aatgtcccac ggtcagagga attcaacagc atccgtacag atccggcatt     8880

ttggtttcac tcaaaatggt ccacagccaa atttgcatgg ctccatataa aacaggtcca     8940

gaggcatctg attgtagcag caagaacaag gtccgcagtc aacaaattag tgacgctgac     9000

ccataaggta ggccaaatct ttgttactcc tgagcttgtc attgtgacac atacagatga     9060

gaacaagttc acgtgtctta cccaggaact tgtgttgatg tatgcagata tgatggaggg     9120

cagagatatg gtcagcataa tatcatccac ggcggcacat cttaggagct tatcagagaa     9180

aattgatgat attctgcggt tagtagatgc tctggcaaga gatttgggca atcaagtcta     9240

cgatgttgta gcactaatgg agggattcgc atacggcgct gttcagctgc ttgaaccgtc     9300

aggtacattt gcgggggatt tcttcgcatt caacctgcag gagctcaaag atactctaac     9360

cggactcctc cccaaggata tcgcagaatc tgtgactcac gcaatcgcaa ccatattctc     9420

tggcttagaa caaaatcaag cagctgagat gttgtgcctg ttgcgtctgt ggggtcaccc     9480

actactcgag tcccgtattg cagcaaaagc agttaggagt caaatgtgcg caccaaaaat     9540

ggtagacttt gatatgatcc tccaggtatt atctttcttt aaaggaacaa tcatcaatgg     9600

atatagaaag aagaatgcag gcgtgtggcc acgtgtcaag atagatacga tatacgggaa     9660

ggtcataggg cagctacacg cagattctgc agagatttca catgatgtca tgttgaggga     9720

atacaagagt ttatctgcac ttgaattcga gccatgtata gagtatgacc ctgtcaccaa     9780

tctgagcatg tttttaaaag acaaggcaat cgcacacccg aaagacaact ggctcgcttc     9840

gtttaggcga aaccttctct ctgaggacca gaagaaacat gtaagagagg caacctcaac     9900

taaccgcctc ttgatagagt tcttagagtc aaatgatttt gatccatata aagagatgga     9960

atatctgacg acccttgagt acctaagaga tgataatgtg gcagtatcat actcactcaa    10020

agaaaaagag gtgaaagtta atgggcggat tttcgcaaag ctaacaaata gattaaggaa    10080

ttgtcaggta atggcagaag ggatcctagc tgaccagatt gcacctttct tccagggaaa    10140

tggggtcatt caggatagca tatctttgac taaaagtatg ctagcgatga gtcaactgtc    10200

tttcaacagc aacaagaaac gtattactga ctgcaaagaa agagtatcct caaaccgcaa    10260

tcatgatccg aagagcaaga atcgtcggag agttgccact tttgtaacta ccgacctgca    10320

aaagtattgt ctcaattgga gatatcagac agtcaagctg ttcgctcatg ccatcaatca    10380

gctgatgggc ttacctcact tcttcgagtg gattcatctt agactaatgg atactacgat    10440

gtttgtaggg gaccctttca atcctccaag tgaccctacg gactgtgatc tatcaagagt    10500

cccaaatgat gacatatata ttgtcagtgc taggggaggc attgagggat tatgccagaa    10560

gctatggaca atgatctcaa ttgctgcaat ccagcttgct gcagcaagat cacattgtcg    10620

cgttgcctgt atggtacaag gcgacaatca agtaatagct ataacgagag aggtaagatc    10680

agatgactcc ccagagatgg tgttaacaca attgcatcaa gccagtgata atttcttcaa    10740

ggaattgatt catgtcaatc atttgatcgg ccataatttg aaggatcgtg aaaccatcag    10800

gtcagacacg ttcttcatat acagcaaacg aatattcaaa gatggagcaa tactcagtca    10860

ggtcctcaaa aactcatcta aattagtgct aatatcaggc gaccttagtg aaaacactgt    10920

aatgtcttgt gccaacattg catctactgt agcacggtta tgcgagaacg ggcttcctaa    10980

ggatttctgt tattacttaa actacttaat gagttgcgtg cagacatact tcgattccga    11040

attttccatc accaacaact cgcaactcga ttctaaccag tcgtggatag aggacatttc    11100

ttttgtgcac tcatatgtcc tgacccctgc tcaactgggg ggactgagta accttcaata    11160

ctcaaggctc tacacaagga acatcggcga cccgggaacc actgctttcg cagagatcaa    11220

gagattagag gcagtggggt tactgagtcc tagcattatg actaacatct taactaggcc    11280

gcctggaaat ggagattggg ccagtctgtg caacgatcca tactccttta attttgagac    11340

tgtcgcaagc ccaaatattg tccttaagaa acatacacaa agagtcctat ttgaaacttg    11400

ctcgaatccc ttattatctg gagtgcacac agaggataat gaggcagaag agaaggcatt    11460

ggctgaattc ttgctcaatc aagaaatgat tcatccacgt gtcgcgcatg ctatcatgga    11520

agcaagctct gtaggtagga gaaagcaaat tcaggggctt gttgacacaa caaacaccgt    11580

gattaagatt gcactgacta ggaggccact cggcatcaag aggctgatgc ggatagtcaa    11640

ttactcgagc atgcatgcaa tgctatttag agatgatgtt ttctcgtcta atagatccaa    11700

ccatccctta gtctcttctg atatgtgttc tcagacactg gcagactatg cacggaacag    11760

aagctggtca cctttgacag ggggtagaaa aatactgggt gtatctaatc ctgataccat    11820

agaacttgta gagggtgaga tccttagtgt cagtggaggg tgcactagat gtgacagtgg    11880

ggatgaacag tttacttggt tccatcttcc aagcaatata gagctaaacg atgacaccag    11940

caagaatcct ccaatgagag tgccatatct cgggtcaaag actcaagaga ggagagccgc    12000

ctcgcttgcg aaaatagctc atatgtcacc acacgtgaag gcggctctaa gggcgtcatc    12060

tgtgttaatc tgggcttatg gggacaacga aataaactgg actgctgccc ttaagattgc    12120

aaggtctcgg tgcaacataa gctcagagta tcttcgacta ttgtcaccct tgcctacagc    12180

tgggaatctc caacatagat tggacgacgg cataactcag atgacattca cccctgcatc    12240

tctatacagg gtgtcacctt acattcatat atctaatgat tctcaaaggc tatttactga    12300

agaaggagtc aaagagggga atgtggttta tcagcaaatc atgctcttgg gtttgtcctt    12360

aattgagtca ctcttcccaa tgacaacaac caagacatat gatgaaatca cattgcacct    12420

ccacagtaaa tttagctgct gtatcaggga agcacctgtt gcagttcctt tcgagctact    12480

cggggtggca ccggaactaa gggcagtaac ctcaaataag tttatgtatg atcctagccc    12540

tgtatcagag ggagactttg cgagacttga cttagctatc tttaagagtt atgaacttaa    12600

tttagagtca tattccacaa tagagctaat gaacgttctt tcaatatcta gtgggaagtt    12660

gattggccag tctgtggttt cttatgatga agatacctcc ataaagaatg acgctataat    12720

agtgtatgac aacacacgga attggatcag cgaagctcag aattcagatg tggtccgcct    12780

attcgagtat gcggcactcg aagtgctcct cgactgttct tatcaactct actatctgag    12840

agtaagaggc ctaaacaata tcgtcctgta catgagtgat ttatacaaga atatgccagg    12900

aattctactc tctaatattg cagccacaat atctcaccct gtcatccatt caaggttgaa    12960

tgcagtaggt ctggtcaacc atgacgggtc acaccaactt gcagacacag atttcattga    13020

aatgtctgca aagctgctag tctcttgcac tcgacgcgtg gtctcaggtt tacatgcagg    13080

gaataagtat gacctgctgt ttccatctgt cttggatgat aacctaagtg agaagatgct    13140

tcagttgata tcccaattat gctgtctgta tacggtgctc tttgctacaa caagagaaat    13200

cccgaaaata agaggcttat ctgcagaaga gaaatgttca gtacttactg agtacctact    13260

gtcagatgct gtgaaaccgt tacttgggtc cgagcaagtg agctctatca tgtctcccaa    13320

catagttacg ttcccagcca atctgtatta catgtctagg aagagcctta atttgatcag    13380

ggagagagag gacagggata ctatcttggc attgttgttc cctcaagaac cgctgctcga    13440

gtttcctctg gtacgagata ttggtgctcg tgtaaaagat ccatttaccc tacaacctgc    13500

ggcgttttta caagagttag atttgagtgc tccggcaagg tatgacgcat tcacaatcag    13560

tcaggcgcat tctgaacaca tattgccaaa cccagaggaa gatcacttag tacgatactt    13620

gttcagagga atagggactg cgtcctcctc ttggtataag gcatcccatc ttctttctgt    13680

acccgaggtc agatgtgcaa ggcatgggaa ctccttatat ttagcagaag gaagtggagc    13740

catcatgagt cttctcgaat tgcatatacc acacgaaact atctattaca atacactttt    13800

ctcgaacgag atgaaccccc cacagcgaca tttcggacca actccaacac agtttctgaa    13860

ttcggttgtt tttaggaatt tacaggcgga agtaccatgc aaggatggat ttgtccagga    13920

gttccgtccg ttatggagag agaatacaga agaaagcgat ctgacctcag ataaagcagt    13980

gggatatatc acatctgtag tgccgtacag gtctgtatca ttgctgcatt gtgacattga    14040

aatccctcca ggatctaatc aaagcttact agatcagctg gctaccaatc tgtctctgat    14100

tgccatgcat tctgtgaagg agggcggggt cgtgattatc aaagtactgt atgcaatggg    14160

atattacttc catctactca tgaacttgtt tactccatgt tccacgaaag gatatattct    14220

ctctaatggc tatgcctgta gaggggatat ggagtgttac ctgatatttg tcatgggcta    14280

cctaggcggg cctacatttg tacatgaggt ggtgaggatg gcaaaaacgc tagtacagcg    14340

gcatggcaca cttttgtcta agtcagatga gattacactg actaggttat ttacttcaca    14400

gcaacagcgt gtaacagaca tcctatccag ccctttaccg agactaatga agtacttgag    14460

agagaatatt gatactgcac tgattgaagc cgggggacag cctgtccgtc cattctgtgc    14520

agagagttta gtgagcacac taacagacat gactcagaca acccagatca tcgccagcca    14580

cattgataca gtcattcgat ctgtgatcta tatggaagca gagggtgatc ttgctgacac    14640

agtattctta tttacccctt acaacctctc tatggacggg aaaaagagaa catcacttaa    14700

acagtgcaca agacagatct tagaggtcac aatactgggt ctcagagtca aaaatctcaa    14760

taaagtaggt gatgtaatca gcctagtact cagaggtatg atttctctgg aggaccttct    14820

cccactgaga acctacttga agtgtagtac ctgccctaag tatttgaagg ctgtcctagg    14880

tattaccaaa ctcaaagaaa tgttcacaga cgcctcttta ttatacttga ctcgtgctca    14940

acaaaaattc tacatgaaaa ctataggcaa tgcagtcaag ggatactata gtaactgtga    15000

ctcttaaagg caaccacata tcaataggcc ctctttctag ccgatcgtat tcttgttgac    15060

ttcattatac catattagaa aaaaattgaa ttccgaccct ttaagactcg tattcggatt    15120

caaataatta tctcagaaaa aaagtgcacg tagttgttct tgattatagt cccgtcattc    15180

accaagtctt tgtttggt                                                  15198




<210> 8
<211> 12
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12bp insert containing a AfeI restriction site


<400> 8
agcgctgacc ga                                                        12




<210> 9
<211> 2238
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-CTLA-4

<400> 9
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagtttggg      60

ctgtcatggg tctttctggt cgctctgttt aggggggtgc agtgtcaggt gcagctggtc     120

gagtcagggg ggggcgtggt gcagccaggc aggtccctga ggctgtcttg cgcagccagc     180

ggcttcacct ttagctccta cacaatgcac tgggtgcggc aggcacctgg caagggcctg     240

gagtgggtga ccttcatctc ctatgacggc aacaataagt actatgccga ttctgtgaag     300

ggccggttta ccatctccag agacaactct aagaatacac tgtacctgca gatgaacagc     360

ctgagggccg aggacaccgc catctactat tgcgcaagga caggatggct gggacctttc     420

gattattggg gccagggcac cctggtgaca gtgtctagcg cctctaccaa gggcccaagc     480

gtgtttcccc tggccccttc ctctaagtcc acctctggag gcacagccgc cctgggctgt     540

ctggtgaagg attacttccc tgagccagtg accgtgagct ggaactccgg cgccctgacc     600

agcggagtgc acacatttcc agccgtgctg cagagcagcg gcctgtactc cctgtctagc     660

gtggtgaccg tgccctcctc tagcctgggc acccagacat atatctgcaa cgtgaatcac     720

aagcctagca atacaaaggt ggacaagcgg gtggagccaa agtcctgtga taagacccac     780

acatgcccac cttgtccagc acctgagctg ctgggaggac catccgtgtt cctgtttcca     840

cccaagccca aggacaccct gatgatcagc cggacccctg aggtgacatg cgtggtggtg     900

gacgtgagcc acgaggaccc cgaggtgaag ttcaactggt acgtggatgg cgtggaggtg     960

cacaatgcca agaccaagcc ccgggaggag cagtacaact ccacctatag agtggtgtct    1020

gtgctgacag tgctgcacca ggactggctg aacggcaagg agtataagtg caaggtgtcc    1080

aataaggccc tgccagcccc catcgagaag accatctcta aggcaaaggg acagccacgg    1140

gagccacagg tgtacacact gcctcccagc cgggacgagc tgaccaagaa ccaggtgagc    1200

ctgacatgtc tggtgaaggg cttctatccc agcgacatcg ccgtggagtg ggagtccaat    1260

ggccagcctg agaacaatta caagaccaca ccccctgtgc tggactctga tggcagcttc    1320

tttctgtatt ctaagctgac cgtggacaag agcagatggc agcagggcaa cgtgtttagc    1380

tgctccgtga tgcacgaggc cctgcacaat cactacacac agaagtctct gagcctgtcc    1440

cctggcaagc ggagaaagag gggcagcgga gagggaaggg gctccctgct gacctgtggc    1500

gatgtggagg agaatcctgg cccaatgaag tatctgctgc caacagctgc cgccggcctg    1560

ctgctgctgg ccgcacagcc cgctatggcc gagatcgtgc tgacccagag cccaggcaca    1620

ctgtctctga gccctggaga gagggccacc ctgtcctgca gagcctccca gtctgtgggc    1680

tcctcttacc tggcctggta tcagcagaag cctggccagg ccccaaggct gctgatctac    1740

ggagccttca gcagggccac cggcatcccc gaccgcttca gcggctccgg ctctggcaca    1800

gacttcaccc tgacaatctc caggctggag cccgaggact tcgccgtgta ctattgccag    1860

cagtacggca gctccccttg gacctttggc cagggcacaa aggtggagat caagaggacc    1920

gtggcagcac catccgtgtt catctttcca ccctctgacg agcagctgaa gagcggcaca    1980

gcctccgtgg tgtgcctgct gaacaacttc tacccccgcg aggccaaggt gcagtggaag    2040

gtggataacg ccctgcagtc cggcaattct caggagagcg tgaccgagca ggactccaag    2100

gattctacat atagcctgtc tagcaccctg acactgagca aggccgatta cgagaagcac    2160

aaggtgtatg cctgtgaggt cacccaccag ggactgtcat cacccgtcac caaaagtttc    2220

aatagaggag agtgctga                                                  2238




<210> 10
<211> 2214
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/Nivolumab

<400> 10
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcctggg tgttcctggt ggccctgttt agaggcgtgc agtgccaggt gcagctggtg     120

gagagcggag gaggagtggt gcagccaggc cggagcctgc gcctggactg taaggccagc     180

ggcatcacct ttagcaactc cggaatgcac tgggtgaggc aggcaccagg caagggcctg     240

gagtgggtgg ccgtgatctg gtacgacggc tctaagcggt actatgccga tagcgtgaag     300

ggccggttca caatctccag agacaactct aagaataccc tgttcctcca gatgaacagc     360

ctgagggccg aggatacagc cgtgtactat tgcgccacca atgacgatta ctggggccag     420

ggcacactgg tgaccgtgag cagcgccagc accaagggac caagcgtgtt cccactggca     480

ccttgctctc gcagcacatc cgagtctacc gccgccctgg gatgtctggt gaaggattat     540

ttccccgagc ctgtgaccgt gagctggaac agcggcgccc tgacatccgg agtgcacacc     600

tttcccgccg tgctccagag cagcggcctg tacagcctgt cctctgtggt gacagtgccc     660

agctcctctc tgggcaccaa gacatatacc tgcaacgtgg accacaagcc tagcaatacc     720

aaggtggata agcgggtgga gtccaagtac ggaccacctt gcccaccatg tccagcacca     780

gagttcctgg gaggaccaag cgtgttcctg tttcctccaa agcccaagga caccctgatg     840

atctccagaa caccagaggt gacctgcgtg gtggtggacg tgtctcagga ggaccccgag     900

gtgcagttca actggtatgt ggatggcgtg gaggtgcaca atgccaagac caagcccagg     960

gaggagcagt ttaactccac ataccgcgtg gtgtctgtgc tgaccgtgct gcaccaggac    1020

tggctgaacg gcaaggagta taagtgcaag gtgtccaata agggcctgcc tagctccatc    1080

gagaagacaa tcagcaaggc aaagggacag ccaagggagc cacaggtgta caccctgccc    1140

ccttctcagg aggagatgac aaagaaccag gtgagcctga cctgtctggt gaagggcttc    1200

tatccttccg acatcgccgt ggagtgggag tctaatggcc agccagagaa caattacaag    1260

accacaccac ccgtgctgga ctctgatggc agcttctttc tgtattccag gctgacagtg    1320

gataagtctc gctggcagga gggcaacgtg tttagctgct ccgtgatgca cgaggccctg    1380

cacaatcact acacccagaa gtctctgagc ctgtccctgg gcaagcggag aaagaggggc    1440

agcggagagg gaaggggctc cctgctgaca tgtggcgacg tggaggagaa tcctggccca    1500

atgaagtatc tgctgcccac cgccgccgcc ggcctgctgc tgctggcagc acagcctgct    1560

atggccgaga tcgtgctgac acagtcccca gccaccctgt ctctgagccc tggagagagg    1620

gccaccctga gctgtagagc atcccagagc gtgagcagct acctggcctg gtatcagcag    1680

aagcctggac aggcaccaag gctgctgatc tacgatgcaa gcaacagggc aacaggcatc    1740

cccgcaagat tcagcggctc cggctctggc accgacttta cactgaccat ctcctctctg    1800

gagcctgagg atttcgccgt gtactattgc cagcagagca gcaattggcc acggacattt    1860

ggccagggca ccaaggtgga gatcaagaga acagtggccg cccctagcgt gttcatcttt    1920

cctccatccg acgagcagct gaagagcggc accgcatccg tggtgtgcct gctgaacaat    1980

ttctacccac gggaggccaa ggtgcagtgg aaggtggata acgccctcca gtccggcaat    2040

tctcaggaga gcgtgacaga gcaggactcc aaggattcta cctatagcct gtctagcaca    2100

ctgaccctgt ccaaggccga ctacgagaag cacaaggtgt atgcctgcga ggtgacacac    2160

cagggcctgt cctctcccgt gaccaagagc tttaacagag gcgagtgttg atga          2214




<210> 11
<211> 2238
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/Atezolizumab

<400> 11
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcctggg tgttcctggt cgccctgttc cggggagtgc agtgtgaggt gcagctggtc     120

gagtctgggg ggggcctggt gcagccagga ggctccctga ggctgtcttg cgcagcaagc     180

ggcttcacct tttctgacag ctggatccac tgggtgagac aggcaccagg caagggcctg     240

gagtgggtgg catggatcag cccttacggc ggctccacct actatgccga cagcgtgaag     300

ggcaggttta caatctccgc cgatacctct aagaacacag cctatctgca gatgaattcc     360

ctgcgcgccg aggataccgc cgtgtactat tgcgcacgga gacactggcc tggaggattt     420

gattactggg gccaggggac cctggtgaca gtgagctccg cctctaccaa gggaccaagc     480

gtgttcccac tggcaccttc tagcaagtcc acctctggag gaacagccgc cctgggctgt     540

ctggtgaagg attactttcc tgagccagtg accgtgagct ggaactccgg cgccctgacc     600

agcggagtgc acacattccc agccgtgctg cagtcctctg gcctgtactc cctgagctcc     660

gtggtgaccg tgccctctag ctccctgggc acccagacat atatctgcaa cgtgaatcac     720

aagccatcca atacaaaggt ggacaagaag gtggagccca agtcttgtga taagacccac     780

acatgcccac cttgtccagc acctgagctg ctgggaggac caagcgtgtt cctgtttcca     840

cccaagccta aggacaccct gatgatcagc aggacccctg aggtgacctg cgtggtggtg     900

gacgtgtccc acgaggatcc agaggtgaag ttcaactggt acgtggatgg cgtggaggtg     960

cacaatgcca agaccaagcc tcgggaggag cagtacgcct ccacctatag agtggtgtct    1020

gtgctgacag tgctgcacca ggactggctg aacggcaagg agtataagtg caaggtgagc    1080

aataaggccc tgccagcccc catcgagaag accatctcca aggcaaaggg acagccaagg    1140

gagccacagg tgtacacact gcctccatct cgcgaggaga tgaccaagaa ccaggtgagc    1200

ctgacatgtc tggtgaaggg cttttatcca agcgacatcg ccgtggagtg ggagtccaat    1260

ggccagcccg agaacaatta caagaccaca ccccctgtgc tggactctga tggcagcttc    1320

tttctgtatt ctaagctgac cgtggataag agcaggtggc agcagggcaa cgtgttcagc    1380

tgctccgtga tgcacgaggc cctgcacaat cactacacac agaagtctct gagcctgtcc    1440

ccaggcaaga ggaggaagag gggaagcgga gagggaagag gctccctgct gacctgtggc    1500

gacgtggagg agaaccctgg cccaatgaag tatctgctgc ccacagcagc cgccggcctg    1560

ctgctgctgg cagcacagcc tgccatggcc gatatccaga tgacccagag cccatctagc    1620

ctgtctgcca gcgtgggcga cagggtgacc atcacatgca gggcaagcca ggacgtgtct    1680

accgccgtgg cctggtacca gcagaagcct ggcaaggccc caaagctgct gatctactcc    1740

gcctctttcc tgtattctgg agtgccaagc cgctttagcg gatccggatc tggaaccgac    1800

ttcaccctga caatctcctc tctgcagccc gaggattttg ccacatacta ttgccagcag    1860

tacctgtatc accctgccac cttcggccag gggaccaagg tggagatcaa gaggaccgtg    1920

gcagcaccat ccgtgttcat ctttccaccc tctgacgagc agctgaagtc cggcacagcc    1980

tctgtggtgt gcctgctgaa caatttctac cctagagagg ccaaggtgca gtggaaggtg    2040

gataacgccc tgcagtccgg caattctcag gagagcgtga ccgagcagga ctccaaggat    2100

tctacatata gcctgagctc caccctgaca ctgtccaagg ccgactacga gaagcacaag    2160

gtgtatgcct gtgaggtcac ccatcagggg ctgtcctcac cagtcacaaa atccttcaat    2220

cggggggaat gctaataa                                                  2238




<210> 12
<211> 2244
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-KIR

<400> 12
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcctggg tgttcctggt ggccctgttc cgcggcgtgc agtgccaagt gcaactggtg     120

cagagcggtg cagaggtgaa gaagccagga tcctctgtga aagtctcatg caaagccagt     180

ggaggtacgt tcagctttta cgcaatcagc tgggtgagac aggctccggg ccaaggtctg     240

gaatggatgg gcggattcat tccaattttc ggcgcagcaa actacgcaca gaagttccag     300

gggcgggtca cgattactgc tgatgagtcg acaagcacag catacatgga gctcagttct     360

ttgagaagcg atgatacagc agtttattac tgtgctagaa ttccaagcgg ttcttattac     420

tatgactacg atatggatgt ctggggacag ggaacaacag tcaccgtatc ttccgcgagc     480

accaagggac cttccgtgtt tcccctggcc ccttgctcca gatcaacctc agagtcgact     540

gctgctctcg gttgcttggt gaaagattat tttccagaac ccgttaccgt gtcttggaac     600

tccggtgccc ttacttcagg ggttcatacc ttccccgcag tcctacagtc atctggtctg     660

tattctctca gctccgtggt caccgtccca agcagctcac tgggcaccaa gacctatacc     720

tgcaacgtcg accataagcc tagtaataca aaggtcgaca agcgagtcga atccaaatac     780

ggacctcctt gtccaccttg ccccgctcct gaattcctgg gtggaccaag cgtctttctg     840

tttccaccaa aacctaaaga cacacttatg atttcccgca cacccgaagt cacctgcgtg     900

gtggtggatg tcagccagga agaccctgag gtgcaattca actggtacgt tgatggcgta     960

gaagtccaca acgccaagac aaaacccaga gaggagcagt ttaatagtac ctatagggtg    1020

gtgtccgtcc tgaccgttct ccaccaggat tggttgaatg gcaaggaata caagtgtaaa    1080

gtgagcaaca aaggcctacc ttcgagcata gaaaagacta tctccaaggc aaagggacag    1140

ccaagggagc cccaggtgta cacgctgcca ccctctcagg aggagatgac taagaaccag    1200

gtgtccttga cctgcctcgt aaaggggttt tacccctccg acatagccgt cgaatgggag    1260

agtaacggac aacccgagaa caattataaa actacacctc ccgtgctcga ctctgacgga    1320

tccttcttcc tgtactctag gctgacagtg gataaatccc gttggcagga aggaaatgta    1380

ttttcctgta gtgtgatgca cgaggctctg cacaatcatt atacacagaa atcactgtcc    1440

ttaagcctcg gcaaacgccg caagcgcggc tccggcgagg gccgcggctc cctgctgacc    1500

tgcggcgacg tggaggagaa ccccggcccc atgaagtacc tgctgcccac cgccgccgcc    1560

ggcctgctgc tgctggccgc ccagcccgcc atggccgaaa tcgtcctcac acagagcccg    1620

gttacgcttt cattgtctcc aggcgagcgc gctaccctca gctgtagggc gtctcagtcc    1680

gtttccagct atttagcttg gtaccagcaa aaacctggcc aggcccctag actgcttatt    1740

tacgacgcct ctaaccgagc gactggtata cccgcaaggt tcagcggctc gggctcaggc    1800

accgacttta ctctcaccat ttcatcactg gagcctgagg acttcgccgt gtattactgt    1860

cagcagagga gtaactggat gtacaccttc ggccaaggga ccaaattgga aatcaaaagg    1920

acagtggccg cgccaagcgt gtttatattt cccccctccg acgaacagtt aaagagtgga    1980

accgcatctg tggtatgtct gcttaacaat ttttaccctc gcgaggcaaa ggttcaatgg    2040

aaagtcgaca acgccttaca gtctggtaac agtcaagagt ctgttacgga gcaagacagc    2100

aaggactcca cctattcgct gtcttcaaca ctaaccctca gcaaggctga ttacgagaag    2160

cacaaagttt acgcctgtga ggtcacccat caggggcttt ctagccctgt cacaaagtcg    2220

ttcaacaggg gagagtgcta atga                                           2244




<210> 13
<211> 2232
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-LAG-3

<400> 13
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcctggg tgttcctggt ggccctgttc cgcggcgtgc agtgccaggt gcaactgcag     120

cagtgggggg ccggactcct gaaaccatcc gaaactctct cattgacttg cgccgtatac     180

ggcgggtcat tttccgatta ctactggaat tggatccgtc agcctccagg taaaggactt     240

gaatggatag gtgaaataaa tcatcgtgga agtactaaca gcaatcctag tctgaaatca     300

agagtaacgc tgagtttgga cacatctaag aaccagtttt cccttaaact tagaagtgtt     360

accgctgctg acacagctgt atactactgt gctttcggtt actccgatta tgagtacaat     420

tggttcgacc cttggggaca gggcacacta gtgacagtgt ccagtgcttc aaccaagggg     480

ccaagcgtgt ttcccttggc cccctgttca cgctccacta gcgaaagcac agccgcgtta     540

ggctgtctgg tgaaagacta ttttccagag ccagtcacgg tgtcttggaa ctcgggtgcc     600

ctgacatcag gtgttcatac tttccccgct gtcctccagt ccagtgggct gtactcatta     660

tcttcggtgg tgactgtccc ctcctcatcg ctggggacga agacctatac ctgtaacgtg     720

gaccacaaac caagcaacac taaggtggac aagcgcgtgg aatccaaata cgggccccca     780

tgcccaccgt gccccgcacc tgagttcctg ggcggtccta gcgtcttttt gttcccaccg     840

aaaccaaagg ataccctcat gatttccagg acgccggagg tcacctgcgt ggtcgtggac     900

gtgagtcagg aggaccccga agtgcaattt aactggtatg tggacggtgt ggaagtccat     960

aatgcaaaga ccaagcctag agaggaacaa tttaatagca cgtaccgggt ggttagtgtc    1020

cttaccgtct tgcaccagga ttggctgaac gggaaggagt ataagtgcaa ggtgtcaaac    1080

aagggactgc cctcatcaat cgagaagaca ataagtaagg cgaagggcca gccacgggag    1140

cctcaggtct acacattgcc gccaagtcaa gaggagatga ccaaaaacca ggtgtctttg    1200

acttgcctcg tgaagggttt ttacccaagt gacatcgccg tagagtggga gtctaacggc    1260

cagccagaga ataactataa aacgacacct ccagtgcttg attctgatgg atcttttttc    1320

ttgtactcaa ggttgaccgt ggataagagc aggtggcaag aaggcaacgt ttttagttgt    1380

tccgttatgc acgaggcctt gcataatcac tatactcaga agtccctatc cctgtctctc    1440

gggcgccgca agcgcggctc cggcgagggc cgcggctccc tgctgacctg cggcgacgtg    1500

gaggagaacc ccggccccat gaagtacctg ctgcccaccg ccgccgccgg cctgctgctg    1560

ctggccgccc agcccgccat ggccgaaatt gtgctgacac aatcgccagc cactctgtct    1620

ctgagccctg gtgagcgggc cactctgtcc tgcagggcca gtcagtctat ttccagctac    1680

ttggcttggt atcagcaaaa acccggccaa gctcctagat tgcttattta cgacgcgagc    1740

aatagggcca ccggtattcc agctcgcttt agcggctccg gaagtggtac tgatttcacg    1800

ctgacaattt caagcttgga acccgaggat tttgcagtgt attactgcca gcagagaagc    1860

aattggccgc tgaccttcgg ccaggggact aatcttgaaa taaaacgcac ggtggctgcc    1920

ccctccgtct tcatctttcc accttctgac gagcaattga agagcggtac cgctagcgta    1980

gtgtgtcttc tgaacaattt ctacccacgc gaggccaaag tgcaatggaa agtcgacaat    2040

gctctgcagt caggaaactc ccaggagagc gtcacagagc aagattctaa agattccact    2100

tacagtctgt catcgacatt gacactgagc aaggccgatt acgaaaagca taaagtgtac    2160

gcttgtgagg tcactcacca aggactgagc tcaccagtta ccaaatcgtt taatagaggt    2220

gagtgttaat ga                                                        2232




<210> 14
<211> 2250
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-NKG2A

<400> 14
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcctggg tgttcctggt ggccctgttc cgcggcgtgc agtgccaggt tcagttggta     120

cagtctggcg cggaggtgaa aaaacctgga gcatctgtca aggtaagttg taaagcttcg     180

ggctatacct ttacctcata ttggatgaac tgggtgcggc aggcccccgg tcaagggctt     240

gaatggatgg gcagaattga tccttatgat tccgaaacac attacgctca gaagctgcag     300

ggcagggtta ccatgacgac agacaccagc acttccactg cttacatgga gctgcgatct     360

ctgcggtcag atgacacggc tgtgtactat tgcgccagag gcggatacga ttttgacgtg     420

gggactctgt attggttctt tgacgtctgg gggcagggaa ccactgtgac agtctcatcg     480

gcgtcaacta aagggccaag cgtgttcccc ttggcaccat gtagtcggtc caccagtgaa     540

agtaccgctg cactcggttg tctggtaaaa gattattttc cagagcccgt tactgtaagc     600

tggaacagtg gggccttgac gtctggagtc catacctttc cggcggtcct tcagtcatct     660

gggctgtaca gcctttccag cgttgtcact gttccaagct cctccctggg cacgaagacc     720

tatacatgta atgtcgacca taagccttca aatacaaaag tagacaaacg tgtggaatca     780

aaatacggac ccccatgccc gccctgtcca gcgcctgaat tcttgggagg cccgtctgtc     840

tttttattcc ccccgaaacc gaaggacacc ctcatgatct caaggacacc agaggtgacc     900

tgcgtggtgg tggatgttag tcaagaggat ccagaggtgc agtttaactg gtatgtcgat     960

ggcgtcgaag tccacaacgc taaaaccaag ccacgggagg agcagtttaa ctctacctat    1020

cgagtggtgt ccgtactgac tgtgttgcac caggactggc ttaatgggaa agaatacaag    1080

tgtaaagttt caaacaaagg cctgccttca agtatcgaaa agactattag caaagctaaa    1140

gggcagccaa gagaaccaca ggtgtacact ttgccccctt cccaagagga gatgactaag    1200

aatcaagttt ctctgacatg tctggtaaaa ggcttctacc cttctgatat agcagtggag    1260

tgggagtcta acggacagcc cgaaaacaat tacaagacga caccccctgt gctagattca    1320

gacggctctt tttttcttta cagtcggctc acagtggata aatcacgctg gcaggaaggg    1380

aatgtcttta gctgcagcgt catgcatgag gctttgcaca accattacac tcagaaatct    1440

ctgagcctct cacttggtaa acgccgcaag cgcggctccg gcgagggccg cggctccctg    1500

ctgacctgcg gcgacgtgga ggagaacccc ggccccatga agtacctgct gcccaccgcc    1560

gccgccggcc tgctgctgct ggccgcccag cccgccatgg ccgatatcca gatgacccag    1620

agcccctcca gccttagcgc ttcagtcggg gatagagtga caattacctg cagagcgtct    1680

gaaaatatct acagctactt ggcctggtac caacagaaac caggcaaagc tcctaagctc    1740

ctgatttata acgcaaaaac cttggctgag ggggtgccca gtcgcttctc gggctctggc    1800

tcaggaaccg actttacact caccatttct tcactgcagc ctgaggactt cgctacgtac    1860

tactgccagc atcactatgg taccccacgc acttttggag gggggactaa ggtggaaatc    1920

aagaggaccg tggccgcccc atccgtattt atcttccccc catccgatga gcagttaaaa    1980

tcagggaccg cctcggttgt gtgtctgctt aacaactttt acccccgcga agctaaggtg    2040

cagtggaagg ttgataacgc cttgcagtct ggaaacagcc aggagagcgt cacagaacaa    2100

gattcaaaag acagtactta ttccctgagt agtacgctga ccctgtccaa agccgattac    2160

gaaaagcaca aagtatacgc gtgtgaggtc actcaccagg gactatcaag cccggtcact    2220

aaatcattca acagggggga gtgctaatga                                     2250




<210> 15
<211> 2238
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-GITR

<400> 15
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcctggg tgttcctggt ggccctgttc cgcggcgtgc agtgccaagt gaccttacgg     120

gaatcaggtc cagcgctggt aaagcccacc caaactctaa cattgacctg tactttcagc     180

ggcttttccc tttcgacaag tggcatgggg gtgggatgga tccggcaacc tcctgggaag     240

gccctcgaat ggctggccca catttggtgg gacgatgaca agtactacaa cccctcactg     300

aagtcacggc tgacgatttc aaaggacacc agcaaaaatc aagtggtact gacgatgacc     360

aatatggatc ccgtcgacac tgctacatac tactgcgctc gcacaaggcg atactttccc     420

ttcgcctatt ggggacaggg aactctggtt accgtgagtt ccgcatccac taagggccca     480

agcgtcttcc cgctggcccc ttccagtaag agcacctccg gagggaccgc tgcacttgga     540

tgcctggtta aagactattt tcctgaacct gttacagtca gttggaactc gggggcacta     600

acctctggag tgcatacctt cccagctgta ctccaatcat ctggactata ctcactttcg     660

tctgtcgtga ctgtgccctc ttcttcactt gggacccaga catatatttg caacgtcaat     720

cataagccat cgaacaccaa ggtggataag aaggtggagc cgaaatcttg tgataagacc     780

cacacatgtc ctccatgccc agcccctgag ctgttgggag gtccctctgt gttcctgttc     840

cccccaaaac caaaagacac cctcatgatc tccagaacgc ctgaggtcac ctgtgtcgtt     900

gtggacgttt ctcacgaaga cccagaggtc aaattcaatt ggtatgtcga cggggtagag     960

gtccacaatg ctaagaccaa gcctcgagaa gagcaatatg cttccactta cagagtggtg    1020

tctgttctga ccgtcctgca ccaagactgg ctaaatggaa aagagtataa atgcaaggtc    1080

agcaacaaag ctctgcccgc cccaattgaa aagactatca gcaaagcgaa aggccagcca    1140

cgggaacctc aggtctatac gctgccccca agccgtgatg agctcacaaa gaaccaggtg    1200

agtctgactt gtctagtgaa aggcttttac cccagtgaca ttgcagtgga gtgggagtcc    1260

aacggacaac ccgaaaacaa ctataaaact accccccccg ttctcgattc tgatggcagc    1320

ttcttcttat acagcaaact tacggtggat aaatcgcggt ggcagcaggg aaatgtgttt    1380

tcctgctctg tcatgcatga ggccctacat aatcactata cacaaaagtc tctctctttg    1440

tcccccggaa aacgccgcaa gcgcggctcc ggcgagggcc gcggctccct gctgacctgc    1500

ggcgacgtgg aggagaaccc cggccccatg aagtacctgc tgcccaccgc cgccgccggc    1560

ctgctgctgc tggccgccca gcccgccatg gccgagatag tgatgactca gtcccccgcc    1620

actctctcag taagcccagg agagagagct acgctgagct gcaaggcctc ccagaacgtg    1680

gggaccaacg tagcctggta ccaacaaaag cccggtcagg ccccccggct gctcatttat    1740

tccgcaagtt atagatattc aggcattccg gccagattta gtggatccgg ctcaggcacg    1800

gagtttacct tgaccattag ctctctccaa tctgaggatt tcgcggtgta ttattgtcag    1860

cagtataaca cagacccctt gaccttcggc ggtggcacaa aagtcgaaat taagaggaca    1920

gtcgccgccc cttccgtgtt cattttcccc ccctcagacg aacagctgaa atctggcaca    1980

gcttcgtggt gtttactgaa caacttctat cccagagaag caaaggtcca gtggaaggtc    2040

gataatgccc tgcagtctgg taatagtcag gagtccgtaa ctgagcagga cagcaaggac    2100

tccacctaca gcctgtcctc taccctgaca ctgagcaaag cagactacga aaaacacaaa    2160

gtgtacgcct gtgaggtcac tcaccagggg ctgagctctc cagtgactaa gtcttttaat    2220

cgcggcgagt gctaatga                                                  2238




<210> 16
<211> 2232
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-OX40

<400> 16
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcctggg tgttcctggt ggccctgttc cgcggcgtgc agtgcgaagt gcagctagtg     120

cagagtgggg gcgggctagt gcagccaggg gggtctcttc gcttgtcttg cgccggtagc     180

ggttttacct tttcatcgta tgcaatgtac tgggtgaggc aagcccctgg caagggattg     240

gagtgggtga gcgcgataga cactgacgcc ggtaccttct atgcggatag tgtaaggggg     300

cgcttcacca ttagtcgcga caacgccaag aactctcttt atctccagat gaattcactc     360

cgagctgagg acaccgcagt ctacttttgt gctaggctgg gggaaggcta cttctttgat     420

tactggggac agggaacctt ggtgactgtg agctctgcct ccacgaaagg tccttctgtt     480

ttcccccttg ccccctcctc aaaatctacc tctggaggta ccgccgctct aggctgccta     540

gtaaaggatt acttccctga acccgtgacg gtgtcttgga acagtggtgc tcttacaagt     600

ggcgtgcaca cctttcctgc cgtgctccaa agttctgggc tttattctct gtcctccgtg     660

gtgaccgtgc ccagcagctc tcttggtacc cagacttaca tctgtaatgt taaccacaaa     720

ccctcaaata caaaggtgga caagagagtg gagccaaaga gctgcgataa aacccacacc     780

tgtcccccct gtcccgcacc tgagcttctt gggggcccta gtgtgtttct gttcccacct     840

aagcccaaag acaccctgat gatctctagg accccggagg ttacctgcgt agttgtggac     900

gtctcccacg aggatcccga ggtgaaattc aattggtacg tcgacggcgt tgaagtccat     960

aacgccaaga ccaagcctcg cgaagaacag tataactcta cctatcgcgt ggtgtcggtc    1020

ctgactgtgc ttcaccagga ctggcttaac gggaaggaat ataaatgcaa ggtcagcaat    1080

aaggccctcc ccgctccaat tgagaagacc atttccaaag ctaaaggcca gccacgggag    1140

ccccaggtct acactctacc accctcccgc gaggagatga ccaaaaacca ggtgtccctg    1200

acctgtttgg tgaagggatt ttacccgtcc gatatcgctg tggagtggga aagtaatggc    1260

caacctgaaa acaactataa gacaaccccg ccagtcctag atagcgatgg atccttcttc    1320

ctgtatagta aacttacagt ggataaaagt aggtggcagc agggtaacgt tttttcgtgt    1380

agtgtgatgc atgaagcact ccacaatcac tatacccaaa aaagcctttc gctgtcccct    1440

ggccgccgca agcgcggctc cggcgagggc cgcggctccc tgctgacctg cggcgacgtg    1500

gaggagaacc ccggccccat gaagtacctg ctgcccaccg ccgccgccgg cctgctgctg    1560

ctggccgccc agcccgccat ggccgagatt gtgctgacgc agagcccagc aactttgagt    1620

ctctcgcccg gcgagcgcgc cacactttcc tgtcgagcct cccaatccgt gagcagttac    1680

ctggcatggt accaacagaa gcctgggcaa gcccccagat tgctgattta tgatgcctcc    1740

aatcgagcaa caggaatacc agctcggttc agtgggagcg gaagcggtac agatttcact    1800

ctgacaatca gctcgctgga gccagaggac ttcgctgttt attactgcca gcagcgttcg    1860

aactggcccc caacgtttgg aggaggcacc aaagtggaaa taaaacgaac agtagcagcc    1920

ccatctgtct tcatcttccc ccccagcgat gaacagctga agtcaggcac tgcttccgtc    1980

gtctgcctac tgaacaattt ttatcctaga gaggccaagg tccaatggaa ggtagacaac    2040

gcactccaat cagggaactc acaagagtct gtcaccgagc aggactctaa ggactcgaca    2100

tactcattat ctagtaccct gacactgagc aaggccgact acgaaaaaca taaagtctac    2160

gcctgtgaag tgacgcacca gggactcagc tctcccgtca ctaagagctt caatcggggg    2220

gagtgttaat ga                                                        2232




<210> 17
<211> 2250
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-VEGF-A

<400> 17
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcctggg tgttcctggt ggccctgttc cgcggcgtgc agtgcgaggt gcagctggtg     120

gagagcggcg gcggcctggt gcagcccggc ggcagcctga ggctgagctg cgccgccagc     180

ggctacacct tcaccaacta cggcatgaac tgggtgaggc aggcccccgg caagggcctg     240

gagtgggtgg gctggatcaa cacctacacc ggcgagccca cctacgccgc cgacttcaag     300

aggaggttca ccttcagcct ggacaccagc aagagcaccg cctacctgca gatgaacagc     360

ctgagggccg aggacaccgc cgtgtactac tgcgccaagt acccccacta ctacggcagc     420

agccactggt acttcgacgt gtggggccag ggcaccctgg tgaccgtgag cagcgccagc     480

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agagcaccag cggcggcacc     540

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac     600

agcggcgccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg     660

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc     720

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc     780

tgcgacaaga cccacacctg ccccccctgc cccgcccccg agctgctggg cggccccagc     840

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg     900

acctgcgtgg tggtggacgt gagccacgag gaccccgagg tgaagttcaa ctggtacgtg     960

gacggcgtgg aggtgcacaa cgccaagacc aagcccaggg aggagcagta caacagcacc    1020

tacagggtgg tgagcgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac    1080

aagtgcaagg tgagcaacaa ggccctgccc gcccccatcg agaagaccat cagcaaggcc    1140

aagggccagc ccagggagcc ccaggtgtac accctgcccc ccagcaggga ggagatgacc    1200

aagaaccagg tgagcctgac ctgcctggtg aagggcttct accccagcga catcgccgtg    1260

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc cgtgctggac    1320

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag gtggcagcag    1380

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag    1440

agcctgagcc tgagccccgg caagcgccgc aagcgcggct ccggcgaggg ccgcggctcc    1500

ctgctgacct gcggcgacgt ggaggagaac cccggcccca tgaagtacct gctgcccacc    1560

gccgccgccg gcctgctgct gctggccgcc cagcccgcca tggccgacat ccagatgacc    1620

cagagcccca gcagcctgag cgccagcgtg ggcgacaggg tgaccatcac ctgcagcgcc    1680

agccaggaca tcagcaacta cctgaactgg taccagcaga agcccggcaa ggcccccaag    1740

gtgctgatct acttcaccag cagcctgcac agcggcgtgc ccagcaggtt cagcggcagc    1800

ggcagcggca ccgacttcac cctgaccatc agcagcctgc agcccgagga cttcgccacc    1860

tactactgcc agcagtacag caccgtgccc tggaccttcg gccagggcac caaggtggag    1920

atcaagagga ccgtggccgc ccccagcgtg ttcatcttcc cccccagcga cgagcagctg    1980

aagagcggca ccgccagcgt ggtgtgcctg ctgaacaact tctaccccag ggaggccaag    2040

gtgcagtgga aggtggacaa cgccctgcag agcggcaaca gccaggagag cgtgaccgag    2100

caggacagca aggacagcac ctacagcctg agcagcaccc tgaccctgag caaggccgac    2160

tacgagaagc acaaggtgta cgcctgcgag gtgacccacc agggcctgag cagccccgtg    2220

accaagagct tcaacagggg cgagtgctga                                     2250




<210> 18
<211> 2232
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-VEGFR

<400> 18
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgtcttggg tgttcctggt cgccctgttt aggggagtgc agtgtgaagt gcagctggtg     120

cagtctgggg ggggcctggt gaagccagga ggcagcctga ggctgtcctg cgcagcatct     180

ggcttcacct ttagctccta cagcatgaac tgggtgcgcc aggcaccagg caagggcctg     240

gagtgggtgt ctagcatctc ctctagctcc tcttacatct actatgccga ctccgtgaag     300

ggcaggttca ccatctctcg cgataacgcc aagaatagcc tgtatctgca gatgaattcc     360

ctgagggccg aggacaccgc cgtgtactat tgcgcccgcg tgacagacgc cttcgacatc     420

tggggccagg gcaccatggt gacagtgagc tccgcctcta ccaagggacc aagcgtgctg     480

ccactggcac catctagcaa gtctaccagc ggaggaacag ccgccctggg atgtctggtg     540

aaggattact tccccgagcc tgtgacagtg tcttggaaca gcggcgccct gaccagcgga     600

gtgcacacat ttcccgccgt gctgcagtcc tctggcctgt actccctgag ctccgtggtg     660

accgtgcctt ctagctccct gggcacccag acatatatct gcaacgtgaa tcacaagcct     720

agcaatacaa aggtggacaa gagggtggag ccaaagtcct gtgataagac ccacacatgc     780

ccaccttgtc cagcaccaga gctgctggga ggaccaagcg tgttcctgtt tccacccaag     840

cccaaggaca ccctgatgat ctctcgcacc cctgaggtga catgcgtggt ggtggacgtg     900

tcccacgagg atccagaggt gaagttcaac tggtacgtgg atggcgtgga ggtgcacaat     960

gccaagacca agcctcggga ggagcagtac aactccacct atagagtggt gtctgtgctg    1020

acagtgctgc accaggactg gctgaacggc aaggagtata agtgcaaggt gagcaataag    1080

gccctgcctg ccccaatcga gaagaccatc tccaaggcaa agggacagcc tagggagcca    1140

caggtgtaca cactgcctcc atccagagag gagatgacca agaaccaggt gtctctgaca    1200

tgtctggtga agggcttcta tccaagcgac atcgccgtgg agtgggagtc caatggccag    1260

cccgagaaca attacaagac cacaccccct gtgctggact ccgatggctc tttctttctg    1320

tattctaagc tgaccgtgga taagagccgg tggcagcagg gcaacgtgtt ttcctgctct    1380

gtgatgcacg aggccctgca caatcactac acacagaaga gcctgtccct gtctcccggc    1440

aagcggagaa agaggggaag cggagaggga agaggctccc tgctgacctg tggcgacgtg    1500

gaggagaacc caggacctat gaagtatctg ctgcctacag cagccgccgg cctgctgctg    1560

ctggcagcac agcccgccat ggccgacatc cagatgaccc agagcccttc tagcgtgagc    1620

gcctccatcg gcgacagggt gaccatcaca tgccgcgcct cccagggcat cgataactgg    1680

ctgggctggt accagcagaa gcccggcaag gcccctaagc tgctgatcta tgacgcctct    1740

aatctggata ccggagtgcc aagccggttc tctggaagcg gctccggcac atactttacc    1800

ctgacaatct cctctctgca ggccgaggac ttcgccgtgt atttttgcca gcaggccaag    1860

gcattcccac ccacctttgg cggaggaaca aaggtggaca tcaagaggac cgtggcagca    1920

ccttccgtgt tcatctttcc tccatctgat gagcagctga agagcggcac agcctccgtg    1980

gtgtgcctgc tgaacaattt ctacccaaga gaggccaagg tgcagtggaa ggtggacaac    2040

gccctgcaga gcggcaattc ccaggagtct gtgaccgagc aggacagcaa ggattccaca    2100

tattctctga gctccaccct gacactgagc aaggccgatt acgagaagca caaggtgtat    2160

gcctgtgagg tcactcacca ggggctgtca agtccagtca ccaagtcctt caatcggggg    2220

gaatgttgat aa                                                        2232




<210> 19
<211> 708
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/NS1

<400> 19
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggatagcaat      60

accatgtcct cctttcaggt tgactgtttc ctgtggcata ttcgcaagcg tttcgccgat     120

aatggtctgg gtgacgcccc gttcctggac cgtctgcgtc gcgatcagaa gagcctgaaa     180

ggccgcggta acaccctggg cctggacatc gaaaccgcga ccctggtggg caagcagatc     240

gtggagtgga ttctgaaaga ggaaagcagc gaaaccctgc gtatgaccat tgccagcgtg     300

ccgaccagcc gttacctgag cgacatgacc ctggaggaaa tgagccgtga ttggttcatg     360

ctgatgccgc gccagaagat cattggtcca ctgtgcgtgc gtctggacca ggctatcatg     420

gagaagaaca ttgtgctgaa agccaacttc agcgtgatct ttaaccgtct ggaaaccctg     480

attctgctgc gcgcctttac cgaggaaggc gcgatcgtgg gcgagattag cccgctgccg     540

agcctgccag gtcacaccta tgaagatgtg aaaaatgccg tgggcgtgct gattggcggt     600

ctggagtgga acggtaacac cgtgcgtgtg agcgaaaaca ttcagcgctt cgcatggcgt     660

aactgtgatg agaatggtcg tccaagcctg ccaccggaac aaaaataa                  708



<210> 20
<211> 1104
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/B18R

<400> 20
ttaagaaaaa atacgggtag aatacaatta acgatcttta tagccaccat gacgatgaaa      60

atgatggtac atatatattt cgtatcatta ttgttattgc tattccacag ttacgccata     120

gacatcgaaa atgaaatcac agaattcttc aataaaatga gagatactct accagctaaa     180

gactctaaat ggttgaatcc agcatgtatg ttcggaggca caatgaatga tatagccgct     240

ctaggagagc cattcagcgc aaagtgtcct cctattgaag acagtctttt atcgcacaga     300

tataaagact atgtggttaa atgggaaagg ctagaaaaaa atagacggcg acaggtttct     360

aataaacgtg ttaaacatgg tgatttatgg atagccaact atacatctaa attcagtaac     420

cgtaggtatt tgtgcaccgt aactacaaag aatggtgact gtgttcaggg tatagttaga     480

tctcatatta gaaaacctcc ttcatgcatt ccaaaaacat atgaactagg tactcatgat     540

aagtatggca tagacttata ctgtggaatt ctttacgcaa aacattataa taatataact     600

tggtataaag ataataagga aattaatatc gacgacatta agtattcaca aacgggaaag     660

gaattaatta ttcataatcc agagttagaa gatagcggaa gatacgactg ttacgttcat     720

tacgacgacg ttagaatcaa gaatgatatc gtagtatcaa gatgtaaaat acttacggtt     780

ataccgtcac aagaccacag gtttaaacta atactagatc caaaaatcaa cgtaacgata     840

ggagaacctg ccaatataac atgcactgct gtgtcaacgt cattattgat tgacgatgta     900

ctgattgaat gggaaaatcc atccggatgg cttataggat tcgattttga tgtatactct     960

gttttaacta gtagaggcgg tattaccgag gcgaccttgt actttgaaaa tgttactgaa    1020

gaatatatag gtaatacata taaatgtcgt ggacacaact attattttga aaaaaccctt    1080

acaactacag tagtattgga gtaa                                           1104




<210> 21
<211> 1662
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/IL-12

<400> 21
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat gggtcaccag      60

cagttggtca tctcttggtt ttccctggtt tttctggcat ctcccctcgt ggccatatgg     120

gaactgaaga aagatgttta tgtcgtagaa ttggattggt atccggatgc ccctggagaa     180

atggtggtcc tcacctgtga cacccctgaa gaagatggta tcacctggac cttggaccag     240

agcagtgagg tcttaggctc tggcaaaacc ctgaccatcc aagtcaaaga gtttggagat     300

gctggccagt acacctgtca caaaggaggc gaggttctaa gccattcgct cctgctgctt     360

cacaaaaagg aagatggaat ttggtccact gatattttaa aggaccagaa agaacccaaa     420

aataagacct ttctaagatg cgaggccaag aattattctg gacgtttcac ctgctggtgg     480

ctgacgacaa tcagtactga tttgacattc agtgtcaaaa gcagcagagg ctcttctgac     540

ccccaagggg tgacgtgcgg agctgctaca ctctctgcag agagagtcag aggggacaac     600

aaggagtatg agtactcagt ggagtgccag gaggacagtg cctgcccagc tgctgaggag     660

agtctgccca ttgaggtcat ggtggatgcc gttcacaagc tcaagtatga aaactacacc     720

agcagcttct tcatcaggga catcatcaaa cctgacccac ccaagaactt gcagctgaag     780

ccattaaaga attctcggca ggtggaggtc agctgggagt accctgacac ctggagtact     840

ccacattcct acttctccct gacattctgc gttcaggtcc agggcaagag caagagagaa     900

aagaaagata gagtcttcac ggacaagacc tcagccacgg tcatctgccg caaaaatgcc     960

agcattagcg tgcgggccca ggaccgctac tatagctcat cttggagcga atgggcatct    1020

gtgccctgca gtgttcctgg agtaggggta cctggggtgg gcgccagaaa cctccccgtg    1080

gccactccag acccaggaat gttcccatgc cttcaccact cccaaaacct gctgagggcc    1140

gtcagcaaca tgctccagaa ggccagacaa actctagaat tttacccttg cacttctgaa    1200

gagattgatc atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca    1260

ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt cataactaat    1320

gggagttgcc tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt    1380

tatgaagact tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gctgctgatg    1440

gatcctaaga ggcagatctt tctagatcaa aacatgctgg cagttattga tgagctgatg    1500

caggccctga atttcaacag tgagactgtg ccacaaaaat cctcccttga agaaccggat    1560

ttttataaaa ctaaaatcaa gctctgcata cttcttcatg ctttcagaat tcgggcagtg    1620

actattgata gagtgatgag ctatctgaat gcttcctaat ga                       1662




<210> 22
<211> 1626
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/(ns)hIL-12

<400> 22
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat gagaaacctc      60

cccgtggcca ctccagaccc aggaatgttc ccatgccttc accactccca aaacctgctg     120

agggccgtca gcaacatgct ccagaaggcc agacaaactc tagaatttta cccttgcact     180

tctgaagaga ttgatcatga agatatcaca aaagataaaa ccagcacagt ggaggcctgt     240

ttaccattgg aattaaccaa gaatgagagt tgcctaaatt ccagagagac ctctttcata     300

actaatggga gttgcctggc ctccagaaag acctctttta tgatggccct gtgccttagt     360

agtatttatg aagacttgaa gatgtaccag gtggagttca agaccatgaa tgcaaagctg     420

ctgatggatc ctaagaggca gatctttcta gatcaaaaca tgctggcagt tattgatgag     480

ctgatgcagg ccctgaattt caacagtgag actgtgccac aaaaatcctc ccttgaagaa     540

ccggattttt ataaaactaa aatcaagctc tgcatacttc ttcatgcttt cagaattcgg     600

gcagtgacta ttgatagagt gatgagctat ctgaatgctt ccggctccgg cgagggccgc     660

ggctccctgc tgacctgcgg cgacgtggag gagaaccccg gccccatatg ggaactgaag     720

aaagatgttt atgtcgtaga attggattgg tatccggatg cccctggaga aatggtggtc     780

ctcacctgtg acacccctga agaagatggt atcacctgga ccttggacca gagcagtgag     840

gtcttaggct ctggcaaaac cctgaccatc caagtcaaag agtttggaga tgctggccag     900

tacacctgtc acaaaggagg cgaggttcta agccattcgc tcctgctgct tcacaaaaag     960

gaagatggaa tttggtccac tgatatttta aaggaccaga aagaacccaa aaataagacc    1020

tttctaagat gcgaggccaa gaattattct ggacgtttca cctgctggtg gctgacgaca    1080

atcagtactg atttgacatt cagtgtcaaa agcagcagag gctcttctga cccccaaggg    1140

gtgacgtgcg gagctgctac actctctgca gagagagtca gaggggacaa caaggagtat    1200

gagtactcag tggagtgcca ggaggacagt gcctgcccag ctgctgagga gagtctgccc    1260

attgaggtca tggtggatgc cgttcacaag ctcaagtatg aaaactacac cagcagcttc    1320

ttcatcaggg acatcatcaa acctgaccca cccaagaact tgcagctgaa gccattaaag    1380

aattctcggc aggtggaggt cagctgggag taccctgaca cctggagtac tccacattcc    1440

tacttctccc tgacattctg cgttcaggtc cagggcaaga gcaagagaga aaagaaagat    1500

agagtcttca cggacaagac ctcagccacg gtcatctgcc gcaaaaatgc cagcattagc    1560

gtgcgggccc aggaccgcta ctatagctca tcttggagcg aatgggcatc tgtgccctgc    1620

agttaa                                                               1626




<210> 23
<211> 924
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/CD80

<400> 23
ttaagaaaaa atacgggtag aagtggcttt cacttttgac cctaagcatc tgccaccatg      60

ggccacacac ggaggcaggg aacatcacca tccaagtgtc catacctcaa tttctttcag     120

ctcttggtgc tggctggtct ttctcacttc tgttcaggtg ttatccacgt gaccaaggaa     180

gtgaaagaag tggcaacgct gtcctgtggt cacaatgttt ctgttgaaga gctggcacaa     240

actcgcatct actggcaaaa ggagaagaaa atggtgctga ctatgatgtc tggggacatg     300

aatatatggc ccgagtacaa gaaccggacc atctttgata tcactaataa cctctccatt     360

gtgatcctgg ctctgcgccc atctgacgag ggcacatacg agtgtgttgt tctgaagtat     420

gaaaaagacg ctttcaagcg ggaacacctg gctgaagtga cgttatcagt caaagctgac     480

ttccctacac ctagtatatc tgactttgaa attccaactt ctaatattag aaggataatt     540

tgctcaacct ctggaggttt tccagagcct cacctctcct ggttggaaaa tggagaagaa     600

ttaaatgcca tcaacacaac agtttcccaa gatcctgaaa ctgagctcta tgctgttagc     660

agcaaactgg atttcaatat gacaaccaac cacagcttca tgtgtctcat caagtatgga     720

catttaagag tgaatcagac cttcaactgg aatacaacca agcaagagca ttttcctgat     780

aacctgctcc catcctgggc cattacctta atctcagtaa atggaatttt tgtgatatgc     840

tgcctgacct actgctttgc cccaagatgc agagagagaa ggaggaatga gagattgaga     900

agggaaagtg tacgccctgt ataa                                            924




<210> 24
<211> 414
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/Apoptin

<400> 24
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat gaacgctctc      60

caagaagata ctccacccgg accatcaacg gtgttcaggc caccaacaag ttcacggccg     120

ttggaaaccc ctcactgcag agagatccgg attggtatcg ctggaattac aatcactcta     180

tcgctgtgtg gctgcgcgaa tgctcgcgct cccacgctaa gatctgcaac tgcggacaat     240

tcagaaagca ctggtttcaa gaatgtgccg gacttgagga ccgatcaacc caagcctccc     300

tcgaagaagc gatcctgcga cccctccgag tacagggtaa gcgagctaaa agaaagcttg     360

attaccacta ctcccagccg accccgaacc gcaaaaaggc gtataagact gtaa           414




<210> 25
<211> 2232
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-CD28

<400> 25
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagtttggg      60

ctgagttggg tctttctggt cgctctgttc cggggggtgc agtgtcaggt gcagctggtg     120

cagtctgggg ccgaggtcaa gaagcccggc gcctccgtga aggtgtcttg caaggccagc     180

ggctacacct tcacaagcta ctatatccac tgggtgaggc aggcaccagg acagggcctg     240

gagtggatcg gctgttaccc tggcaacgtg aataccaact ataatgagaa gtttaaggac     300

cgcgccacaa tcctgacctg ggatacaagc tccaccgcct atatggagct gtccaggctg     360

cgctctgacg atacagccgt gtacttctgc accaggtccc actatggcct gcagtggaac     420

tttgacgtgt ggggccaggg caccacagtg acagtgtcta gcgcctctac caagggccct     480

agcgtgttcc ctctggcccc atgctcccgc tctacaagcg agtccaccgc cgccctggga     540

tgtctggtga aggattactt ccctgagcca gtgaccgtga gctggaattc cggcgccctg     600

acaagcggag tgcacacctt tccagccgtg ctgcagtcct ctggcctgta ctccctgagc     660

tccgtggtga cagtgccttc tagctccctg ggcaccaaga catatacctg caacgtggac     720

cacaagccaa gcaataccaa ggtggataag cgggtggaga gcaagtacgg accaccttgc     780

ccatcctgtc cagcacctga gtttctggga ggaccttccg tgttcctgtt tccacccaag     840

ccaaaggaca cactgatgat ctctagaaca cccgaggtga cctgcgtggt ggtggacgtg     900

agccaggagg atcctgaggt gcagttcaac tggtacgtgg atggcgtgga ggtgcacaat     960

gccaagacca agccacggga ggagcagttt aactccacat acagagtggt gtctgtgctg    1020

accgtgctgc accaggactg gctgaacggc aaggagtata agtgcaaggt gtccaataag    1080

ggcctgccct ctagcatcga gaagacaatc tctaaggcaa agggacagcc aagggagcct    1140

caggtgtaca ccctgcctcc aagccaggag gagatgacaa agaaccagtg gtccctgacc    1200

tgtctggtga agggcttcta tccttctgac atcgccgtgg agtgggagag caatggccag    1260

ccagagaaca attacaagac cacaccccct gtgctggact ctgatggcag cttctttctg    1320

tattctaggc tgacagtgga taagagccgc tggcaggagg gcaacgtgtt ttcttgcagc    1380

gtgatgcacg aggccctgca caatcactac acccagaagt ccctgtctct gagcctgggc    1440

aagcggagaa agaggggaag cggagaggga agaggctccc tgctgacatg tggcgatgtg    1500

gaggagaacc caggccccat gaagtatctg ctgcccaccg cagccgccgg cctgctgctg    1560

ctggcagccc agccagccat ggccgacatc cagatgaccc agagcccatc ctctctgtcc    1620

gcctctgtgg gcgatagggt gacaatcacc tgccacgcct cccagaacat ctacgtgtgg    1680

ctgaattggt atcagcagaa gccaggcaag gcccccaagc tgctgatcta caaggcctcc    1740

aatctgcaca caggagtgcc ttctcgcttc agcggatccg gatctggaac cgactttaca    1800

ctgaccatca gctccctgca gccagaggat ttcgccacct actattgcca gcagggccag    1860

acatacccct atacctttgg cggcggcaca aaggtggaga tcaagaggac cgtggcagca    1920

ccatccgtgt tcatctttcc accctctgac gagcagctga agagcggaac cgcatccgtg    1980

gtgtgcctgc tgaacaattt ctaccctaga gaggccaagg tgcagtggaa ggtggataac    2040

gccctgcagt ccggcaattc tcaggagagc gtgacagagc aggactccaa ggattctacc    2100

tatagcctgt ctagcacact gaccctgagc aaggccgact acgagaagca caaggtgtat    2160

gcctgtgaag tcacccacca ggggctgagt tcaccttgga caaagagttt caatcgggga    2220

gagtgttgat aa                                                        2232




<210> 26
<211> 2232
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-CD33 (Gemtuzumab)

<400> 26
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgagttggg tgttcctggt cgccctgttt cggggggtcc agtgtgaagt gcagctggtc     120

cagtccgggg cagaagtcaa gaagccaggc agctccgtga aggtgtcttg caaggccagc     180

ggctacacca tcacagactc caacatccac tgggtgaggc aggcacctgg acagtctctg     240

gagtggatcg gctacatcta tccatacaat ggcggcaccg actataacca gaagttcaag     300

aatagggcca ccctgacagt ggataacccc accaatacag cctacatgga gctgtctagc     360

ctgcgcagcg aggacacagc cttttactat tgcgtgaacg gcaatccatg gctggcctat     420

tggggccagg gcacactggt gaccgtgtcc tctgccagca ccaagggacc atccgtgttc     480

ccactggcac cttgctcccg ctctacaagc gagtccaccg ccgccctggg atgtctggtg     540

aaggattact tccccgagcc tgtgaccgtg tcctggaact ctggcgccct gacaagcgga     600

gtgcacacct ttccagccgt gctgcagagc tccggcctgt attccctgtc tagcgtggtg     660

acagtgccct cctctagcct gggcaccaag acatacacct gcaacgtgga ccacaagcct     720

agcaatacca aggtggataa gcgggtggag tccaagtatg gaccaccttg cccaccatgt     780

ccagcaccag agtttctggg aggaccaagc gtgttcctgt ttcctccaaa gcctaaggac     840

accctgatga tcagcagaac accagaggtg acctgcgtgg tggtggacgt gtcccaggag     900

gatcccgagg tgcagttcaa ctggtacgtg gatggcgtgg aggtgcacaa tgccaagacc     960

aagccccggg aggagcagtt taattctaca tatagagtgg tgagcgtgct gaccgtgctg    1020

caccaggatt ggctgaacgg caaggagtac aagtgcaagg tgagcaataa gggcctgcct    1080

tcctctatcg agaagacaat ctccaaggca aagggacagc caagggagcc acaggtgtat    1140

accctgcccc cttctcagga ggagatgaca aagaaccagg tgagcctgac ctgtctggtg    1200

aagggcttct acccctccga catcgccgtg gagtgggagt ctaatggcca gcctgagaac    1260

aattataaga ccacaccacc cgtgctggac agcgatggct ccttctttct gtacagcagg    1320

ctgacagtgg ataagtcccg ctggcaggag ggcaacgtgt tttcttgcag cgtgatgcac    1380

gaggccctgc acaatcacta tacccagaag tccctgtctc tgagcctggg caagcggaga    1440

aagaggggat ccggagaggg aaggggctct ctgctgacat gtggcgacgt ggaggagaac    1500

cctggcccaa tgaagtacct gctgcctacc gcagccgccg gcctgctgct gctggcagcc    1560

cagccagcca tggccgatat ccagctgaca cagtccccat ctaccctgag cgcctccgtg    1620

ggcgaccggg tgacaatcac ctgcagagcc tctgagagcc tggataacta tggcatccgg    1680

ttcctgacat ggtttcagca gaagcctggc aaggccccaa agctgctgat gtacgcagca    1740

tccaatcagg gatctggagt gcccagcaga ttctccggct ctggcagcgg caccgagttt    1800

acactgacca tcagctccct gcagcctgac gatttcgcca catactattg ccagcagacc    1860

aaggaggtgc catggagctt tggccagggc acaaaggtgg aggtgaagag gaccgtggca    1920

gcacctagcg tgttcatctt tcctccaagc gacgagcagc tgaagtccgg caccgcctct    1980

gtggtgtgcc tgctgaacaa tttctatcca cgcgaggcca aggtgcagtg gaaggtggat    2040

aacgccctgc agtctggcaa tagccaggag tccgtgacag agcaggactc taaggatagc    2100

acctactccc tgtctagcac actgaccctg tccaaggccg actatgagaa gcacaaggtg    2160

tacgcctgtg aggtcaccca tcaggggctg tcatcaccag tcacaaagag tttcaatcgg    2220

ggggagtgct ga                                                        2232




<210> 27
<211> 2250
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-CD39

<400> 27
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgagttggg tgttcctggt cgccctgttt cggggggtcc agtgccagat ccagctggtg     120

cagtccggcc ctgagctgaa gaagccaggc gagacagtga agatctcttg caaggccagc     180

ggctacacat tccggaacta tggcatgaat tgggtgaagc aggcaccagg caagggcctg     240

aagtggatgg gctggatcaa cacctacaca ggcgagccta cctatgccga cgacttcaag     300

ggcaggttcg cctttagcct ggccacctcc gcctctacag cctacctgca gatctccaac     360

ctgaagaatg aggacaccgc cacatatttc tgcgcccgca aggcctacta tggcagcaat     420

tactattttg attactgggg ccagggcacc acactgaccg tgagctccgc ctctacaaag     480

ggacctagcg tgttcccact ggcaccatct agcaagagca cctccggagg aacagccgcc     540

ctgggctgtc tggtgaagga ctacttcccc gagcctgtga ccgtgtcctg gaactctggc     600

gccctgacca gcggagtgca cacatttcca gccgtgctgc agtcctctgg cctgtactcc     660

ctgagctccg tggtgaccgt gccctctagc tccctgggca cccagacata tatctgcaac     720

gtgaatcaca agccttccaa tacaaaggtg gacaagaggg tggagccaaa gtcttgtgat     780

aagacccaca catgcccacc ttgtccagca ccagagctgc tgggaggacc atccgtgttc     840

ctgtttccac ccaagcccaa ggacaccctg atgatctctc gcacccctga ggtgacatgc     900

gtggtggtgg acgtgagcca cgaggatcca gaggtgaagt tcaactggta cgtggatggc     960

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtaccagtc cacctatcgc    1020

gtggtgtctg tgctgacagt gctgcaccag gactggctga acggcaagga gtacaagtgc    1080

aaggtgtcca ataaggccct gcctgcccca atcgagaaga ccatctctaa ggcaaaggga    1140

cagcctaggg agccacaggt gtacacactg cctccatcta gagaggagat gaccaagaac    1200

caggtgagcc tgacatgtct ggtgaagggc ttctatccca gcgacatcgc cgtggagtgg    1260

gagtccaatg gccagcctga gaacaattac aagaccacac cccctgtgct ggacagcgat    1320

ggctccttct ttctgtattc taagctgacc gtggataaga gccggtggca gcagggcaac    1380

gtgttttctt gcagcgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg    1440

tctctgagcc caggcaagag gagaaagagg ggaagcggag agggaagggg ctccctgctg    1500

acctgtggcg acgtggagga gaacccagga cctatgaagt atctgctgcc aacagcagcc    1560

gccggcctgc tgctgctggc agcacagccc gccatggccg atatcgtgat gacccagagc    1620

cacaagttca tgtccacatc tgtgggcgac agggtgtcca tcacctgcaa ggcatcccag    1680

gacgtgagca cagcagtggc atggtaccag cagaagccag gacagagccc taagctgctg    1740

atctatagcg cctcctaccg gtataccggc gtgcctgaca gattcaccgg ctctggcagc    1800

ggcacagatt tcacctttac aatctccaca gtgcaggccg aggacctggc cgtgtactat    1860

tgccagcagc actacaccac accaccctat acctttggcg gcggcacaaa gctggagatc    1920

aagaggaccg tggcagcacc ttccgtgttc atctttcctc catctgacga gcagctgaag    1980

agcggcacag cctccgtggt gtgcctgctg aacaacttct acccaagaga ggccaaggtg    2040

cagtggaagg tggataacgc cctgcagtct ggcaatagcc aggagtccgt gaccgagcag    2100

gactctaagg atagcacata ttccctgtct agcaccctga cactgagcaa ggccgattac    2160

gagaagcaca aggtgtatgc ctgtgaagtg acccaccagg ggctgtcctc tccagtgacc    2220

aaatctttca ataggggcga atgctgataa                                     2250




<210> 28
<211> 2256
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-CA 15-3

<400> 28
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggc      60

ctgagttggg tcttcctggt cgccctgttt cggggggtcc agtgtgaggt ccagctgcag     120

cagtccgggg gagagagagc cacccccggc gcctccgtga agatgtcttg caagacaagc     180

ggctacacct tcacaaacta ttggatgcac tgggtgaagc agcggcccgg acagggcctg     240

gagtggatca tcggctacat caaccctagc tccggctaca cccagtataa tcagaagttt     300

aaggacaagg ccaccctgac agccgataag tctagctcca ccgcctatat ccagctgtct     360

agcctgacat ctgaggacag cgccgtgtac tattgctcca cctactatgg cgattacctg     420

ttcccatatt ggggacaggg caccctggtg acagtgtccg ccgcatctac aaagggacca     480

agcgtgtttc cactggcacc ttcctctaag tctaccagcg gaggaacagc cgccctggga     540

tgtctggtga aggactactt ccctgagcca gtgaccgtga gctggaactc cggcgccctg     600

acctccggag tgcacacatt tcctgccgtg ctgcagagct ccggcctgta cagcctgtct     660

agcgtggtga ccgtgccatc ctctagcctg ggcacccaga catatatctg caacgtgaat     720

cacaagcctt ccaatacaaa ggtggacaag cgggtggagc caaagtcttg tgataagacc     780

cacacatgcc caccttgtcc agcacctgag ctgctgggag gaccaagcgt gttcctgttt     840

ccacccaagc ccaaggacac cctgatgatc agcagaaccc ccgaggtgac atgcgtggtg     900

gtggacgtgt cccacgagga tcctgaggtg aagttcaact ggtacgtgga tggcgtggag     960

gtgcacaatg ccaagaccaa gcctcgggag gagcagtaca actccaccta tagagtggtg    1020

tctgtgctga cagtgctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtg    1080

tctaataagg ccctgccagc ccccatcgag aagaccatca gcaaggcaaa gggacagcca    1140

agggagccac aggtgtacac actgcctcca tctcgcgacg agctgaccaa gaaccaggtg    1200

agcctgacat gtctggtgaa gggcttctat ccaagcgaca tcgccgtgga gtgggagtcc    1260

aatggccagc ccgagaacaa ttacaagacc acaccccctg tgctggactc tgatggcagc    1320

ttctttctgt attctaagct gaccgtggat aagagccggt ggcagcaggg caacgtgttt    1380

tcctgctctg tgatgcacga ggccctgcac aatcactaca cacagaagag cctgtccctg    1440

tctcccggca agcggagaaa gaggggaagc ggagagggaa gaggctccct gctgacctgt    1500

ggcgacgtgg aggagaaccc tggcccaatg aagtatctgc tgcctacagc agccgccggc    1560

ctgctgctgc tggcagcaca gccagccatg gccgatgtgc tgatgaccca gacaccactg    1620

tccctgccag tgtctctggg cgaccaggcc agcatctcct gcaggtcctc tcaggacatc    1680

gtgtacggca acggcaatac ctacctggag tggtatctgc agaagcccgg ccagtcccct    1740

aagctgctga tctataaggt gagcaatagg ttctccggcg tgccagaccg cttttctggc    1800

agcggctccg gcaccgattt cacactgaag atctccaggg tggaggcaga ggacctgggc    1860

gtgtactatt gcttccaggg cagccacgtg ccctacacct ttggcggcgg cacaaagctg    1920

gagatcaaga ggaggaccgt ggcagcacct tccgtgttca tctttccacc ctctgacgag    1980

cagctgaagt ctggcacagc cagcgtggtg tgcctgctga acaacttcta ccccagggag    2040

gccaaggtgc agtggaaggt ggataacgcc ctgcagtccg gcaattctca ggagagcgtg    2100

accgagcagg actccaagga ttctacatat agcctgagct ccaccctgac actgagcaag    2160

gccgattacg agaagcacaa ggtgtatgcc tgtgaggtca cccaccaggg actgagtagc    2220

cccgtcacca aatccttcaa tagaggcgag tgttga                              2256




<210> 29
<211> 2262
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/ anti-CA 19-9

<400> 29
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagtttggg      60

ctgtcatggg tctttctggt cgctctgttt cggggggtgc agtgtcaggt gcagctggtc     120

gagtcagggg ggggaagtgt gcagcctggc cggagcctga gactgagctg cgaggcatcc     180

ggcttcacct ttgaggcata cgcaatgcac tgggtgcggc agccacctgg caagggcctg     240

gagtgggtga gctccatcaa ctggaattcc ggccggatcg cctacgccga ctctgtgaag     300

ggcagattca ccatcagcag ggataacgcc cgcaattccc tgtatctgca gatgaactct     360

ctgagactgg aggacaccgc cttttactat tgcgccaagg acatccggag attcagcaca     420

ggcggcgccg agtttgagta ctggggccag ggcaccctgg tgacagtgtc tagcgccagc     480

accaagggac catccgtgtt ccctctggca ccatcctcta agagcacctc cggaggaaca     540

gccgccctgg gctgtctggt gaaggactat ttcccagagc ccgtgacagt gtcctggaac     600

tctggcgccc tgaccagcgg agtgcacaca tttcctgccg tgctgcagag ctccggcctg     660

tactccctgt ctagcgtggt gaccgtgcca tcctctagcc tgggcaccca gacatatatc     720

tgcaacgtga atcacaagcc atccaataca aaggtggaca agagggtgga gcccaagtct     780

tgtgataaga cccacacatg cccaccctgt cctgcaccag agctgctggg aggaccaagc     840

gtgttcctgt ttcctccaaa gcctaaggac accctgatga tcagccgcac cccagaggtg     900

acatgcgtgg tggtggacgt gtcccacgag gatcccgagg tgaagttcaa ctggtacgtg     960

gatggcgtgg aggtgcacaa tgccaagacc aagcccaggg aggagcagta caactctacc    1020

tatcgcgtgg tgagcgtgct gacagtgctg caccaggact ggctgaacgg caaggagtat    1080

aagtgcaagg tgtctaataa ggccctgccc gcccctatcg agaagaccat ctccaaggca    1140

aagggacagc caagggagcc tcaggtgtac acactgcccc cttctcgcga cgagctgacc    1200

aagaaccagg tgagcctgac atgtctggtg aagggcttct atcctagcga catcgccgtg    1260

gagtgggagt ccaatggcca gccagagaac aattacaaga ccacaccacc cgtgctggac    1320

agcgatggct ccttctttct gtatagcaag ctgaccgtgg acaagtccag gtggcagcag    1380

ggcaacgtgt tttcttgcag cgtgatgcac gaggccctgc acaatcacta cacacagaag    1440

tccctgtctc tgagcccagg caagaggagg aagaggggat ccggagaggg aagaggctct    1500

ctgctgacct gtggcgatgt ggaggagaat ccaggcccca tgaagtatct gctgcccaca    1560

gcagccgccg gcctgctgct gctggcagca cagcctgcca tggcccagag cgtgctgacc    1620

cagcctccat ccgcctctgg aaccccagga cagagggtga caatcagctg ctccggctcc    1680

tctagcaaca tcggcagcaa tttcgtgtac tggtatcagc agctgccagg aaccgcacca    1740

aagctgctga tctacaggaa caatcagcgg ccctccggag tgccagacag gttttctggc    1800

agccgctccg gcacatctgc cagcctggcc atctctggcc tgcggagcga ggacgaggca    1860

gattactatt gcgcagcatg ggacgatagc ctgggaggac actacgtgtt cggaaccgga    1920

acaaaggtga ccgtgctgag aacagtggca gcaccaagcg tgttcatctt tccccctagc    1980

gacgagcagc tgaagtccgg caccgcctct gtggtgtgcc tgctgaacaa cttctaccct    2040

agagaggcca aggtgcagtg gaaggtggat aacgccctgc agtctggcaa tagccaggag    2100

tccgtgaccg agcaggactc taaggatagc acatattccc tgtcctctac cctgacactg    2160

tccaaggccg attacgagaa gcacaaggtg tatgcctgtg aagtgaccca ccagggactg    2220

agcagccccg tgaccaaatc tttcaaccga ggcgaatgtt ga                       2262




<210> 30
<211> 2232
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-CA 125

<400> 30
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagtttggg      60

ctgtcctggg tgttcctggt cgctctgttt aggggggtgc agtgtgaagt gcagctggtc     120

gtcgagtccg gggggggcct ggtgcagcca ggaggcagcc tgaggctgtc ctgcgcagca     180

tccggctact ctatcaccaa cgactatgcc tggaattggg tgagacaggc accaggcaag     240

ggcctggagt gggtgggcta catctcttat agcggctaca ccacatataa ccccagcctg     300

aagtccaggt tcaccatctc tcgcgatacc agcaagaaca cactgtacct gcagatgaat     360

tccctgaggg cagaggacac cgccgtgtac tattgcgcca gatggacaag cggcctggat     420

tattggggcc agggcaccct ggtgacagtg agctccgcca gcaccaaggg cccttccgtg     480

tttcccctgg ccccttctag caagtccacc tctggaggaa cagccgccct gggctgtctg     540

gtgaaggact acttccctga gccagtgacc gtgtcttgga acagcggcgc cctgacctcc     600

ggagtgcaca catttcccgc cgtgctgcag tcctctggcc tgtacagcct gagctccgtg     660

gtgaccgtgc cttctagctc cctgggcacc cagacatata tctgcaacgt gaatcacaag     720

ccatccaata caaaggtgga caagcgggtg gagcccaagt cttgtgataa gacccacaca     780

tgcccacctt gtccagcacc tgagctgctg ggaggaccat ccgtgttcct gtttccaccc     840

aagcctaagg acaccctgat gatcagcaga accccagagg tgacatgcgt ggtggtggac     900

gtgtcccacg aggatcccga ggtgaagttc aactggtacg tggatggcgt ggaggtgcac     960

aatgccaaga ccaagcccag ggaggagcag tacaactcta cctatcgcgt ggtgagcgtg    1020

ctgacagtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtctaat    1080

aaggccctgc cagcccccat cgagaagacc atcagcaagg caaagggaca gccaagggag    1140

ccacaggtgt acacactgcc tccatctcgc gacgagctga ccaagaacca ggtgagcctg    1200

acatgtctgg tgaagggctt ctatcccagc gacatcgccg tggagtggga gtccaatggc    1260

cagcctgaga acaattacaa gaccacaccc cctgtgctgg actccgatgg ctctttcttt    1320

ctgtatagca agctgaccgt ggataagtcc cggtggcagc agggcaacgt gtttagctgc    1380

tccgtgatgc acgaggccct gcacaatcac tacacacaga agtctctgag cctgtcccca    1440

ggcaagagga gaaagagggg atccggcgag ggcagaggct ctctgctgac ctgtggcgac    1500

gtggaggaga accctggccc aatgaagtat ctgctgccta cagcagccgc cggcctgctg    1560

ctgctggcag cacagcctgc catggccgac atccagatga cccagtcccc atctagcctg    1620

tctgccagcg tgggcgacag ggtgaccatc acatgcaagg ccagcgatct gatccacaat    1680

tggctggcct ggtaccagca gaagcctggc aaggccccaa agctgctgat ctatggagcc    1740

acctctctgg agacaggagt gccaagccgc ttctccggat ctggaagcgg caccgacttt    1800

accctgacaa tctcctctct gcagcctgag gatttcgcca catactattg ccagcagtac    1860

tggaccacac cattcacctt tggccagggc acaaaggtgg agatcaagag gaccgtggcc    1920

gccccttccg tgttcatctt tccaccctct gacgagcagc tgaagtccgg cacagcctct    1980

gtggtgtgcc tgctgaacaa cttctaccca cgcgaggcca aggtgcagtg gaaggtggat    2040

aacgccctgc agagcggcaa ttcccaggag tctgtgaccg agcaggacag caaggattcc    2100

acatattctc tgagctccac cctgacactg agcaaggccg actacgagaa gcacaaggtg    2160

tatgcctgtg aagtcaccca ccaggggctg tcatcaccag tcactaagag tttcaatcgg    2220

ggggaatgct ga                                                        2232




<210> 31
<211> 2238
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-EGFR

<400> 31
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggg      60

ctgagttggg tgttcctggt cgctctgttt cggggggtgc agtgtcaggt gcagctgaag     120

cagtctgggc ctgggctggt ccagccctct cagagcctgt ccatcacctg cacagtgtct     180

ggcttcagcc tgaccaatta cggagtgcac tgggtgcggc agagccctgg caagggcctg     240

gagtggctgg gcgtgatctg gtccggaggc aatacagact ataacacccc cttcacctcc     300

agactgtcta tcaataagga taactctaag agccaggtgt tctttaagat gaatagcctg     360

cagtccaacg acaccgccat ctactattgc gccagggccc tgacatacta tgattacgag     420

ttcgcctatt ggggccaggg caccctggtg acagtgtctg ccgccagcac caagggccct     480

agcgtgtttc ccctggcccc tagctccaag tccacctctg gaggaacagc cgccctgggc     540

tgtctggtga aggactactt ccctgagcca gtgaccgtgt cctggaattc tggcgccctg     600

accagcggcg tgcacacatt tcccgccgtg ctgcagtcta gcggcctgta ctccctgtcc     660

tctgtggtga ccgtgcctag ctcctctctg ggcacccaga catatatctg caatgtgaac     720

cacaagccat ccaacacaaa ggtggacaag aaggtggagc ccaagtcttg tgataagacc     780

cacacatgcc caccttgtcc agcacctgag ctgctgggag gaccatccgt gttcctgttt     840

ccacccaagc ctaaggacac cctgatgatc tctagaaccc cagaggtgac atgcgtggtg     900

gtggacgtgt cccacgagga tcccgaggtg aagttcaatt ggtacgtgga tggcgtggag     960

gtgcacaacg ccaagaccaa gccacgggag gagcagtaca actccaccta tagagtggtg    1020

tctgtgctga cagtgctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtg    1080

agcaacaagg ccctgccagc ccccatcgag aagaccatct ccaaggcaaa gggacagcca    1140

agggagccac aggtgtacac actgcctcca tctcgcgacg agctgaccaa gaatcaggtg    1200

agcctgacat gtctggtgaa gggcttctat cctagcgaca tcgcagtgga gtgggagtcc    1260

aacggacagc cagagaacaa ttacaagacc acaccccctg tgctggacag cgatggctcc    1320

ttctttctgt attctaagct gaccgtggat aagagccggt ggcagcaggg caacgtgttc    1380

agctgctccg tgatgcacga ggccctgcac aaccactaca cacagaagtc tctgagcctg    1440

tcccctggca agcggagaaa gaggggaagc ggagagggaa ggggctccct gctgacctgt    1500

ggcgacgtgg aggagaatcc tggcccaatg aagtatctgc tgcccacagc agccgccggc    1560

ctgctgctgc tggcagcaca gcctgccatg gccgacatcc tgctgaccca gagccctgtg    1620

atcctgtctg tgagcccagg cgagcgggtg tccttctctt gcagagccag ccagtccatc    1680

ggcaccaata tccactggta ccagcagagg acaaacggca gccctcgcct gctgatcaag    1740

tatgcctctg agagcatctc cggcatccca tccagattct ctggcagcgg ctccggcacc    1800

gactttacac tgtctatcaa cagcgtggag tccgaggaca tcgccgatta ctattgccag    1860

cagaacaata actggccaac cacattcggc gccggcacca agctggagct gaagaggaca    1920

gtggccgccc cctccgtgtt catctttcca ccctctgacg agcagctgaa gtctggcacc    1980

gccagcgtgg tgtgcctgct gaataacttt tacccccgcg aggccaaggt gcagtggaag    2040

gtggataatg ccctgcagtc tggcaacagc caggagtccg tgaccgagca ggactctaag    2100

gatagcacat attccctgag ctccaccctg acactgagca aggccgatta cgagaagcac    2160

aaggtgtatg cctgtgaagt cacccaccag gggctgtcct cacccgtcac aaaatctttc    2220

aatagggggg agtgttga                                                  2238




<210> 32
<211> 1458
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-nfP2X7

<400> 32
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagttcggg      60

ctgagttggg tgttcctggt cgctctgttt aggggggtgc agtgtgaagt gcagctgctg     120

gagtccgggg ggggcctggt ccagccagga ggcagcctga ggctgtcctg cgcagcatct     180

ggcttcacct ttaggaacca cgacatggga tgggtgcgcc aggcacctgg caagggcctg     240

gagtgggtga gcgccatctc tggaagcgga ggatccacat actatgccaa ctctgtgaag     300

ggccggttca ccatcagcag agacaactcc aagaatacac tgtacctgca gatgaatagc     360

ctgcgggccg aggataccgc cgtgtactat tgcgccgagc caaagcccat ggacacagag     420

ttcgattata gatccccagg caccctggtg acagtgagct ccgcctctac caagggcccc     480

agcgtgtttc ctctggcccc atctagcaag tccacctctg gaggaacagc cgccctgggc     540

tgtctggtga aggattactt ccctgagcca gtgacagtgt cttggaacag cggcgccctg     600

acctctggag tgcacacatt tcccgccgtg ctgcagtcct ctggcctgta ctccctgagc     660

tccgtggtga ccgtgccttc tagctccctg ggcacccaga catatatctg caacgtgaat     720

cacaagcctt ctaatacaaa ggtggacaag agggtggagc caaagagctg tgataagacc     780

cacacatgcc caccttgtcc agcacctgag ctgctgggag gaccaagcgt gttcctgttt     840

ccacccaagc ccaaggacac cctgatgatc tcccgcaccc ctgaggtgac atgcgtggtg     900

gtggacgtgt ctcacgagga tccagaggtg aagtttaact ggtacgtgga tggcgtggag     960

gtgcacaatg ccaagaccaa gccccgggag gagcagtaca acagcaccta tagagtggtg    1020

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aggagtataa gtgcaaggtg    1080

agcaataagg ccctgccagc ccccatcgag aagaccatct ccaaggcaaa gggacagcca    1140

agggagcctc aggtgtacac actgcctcca agccgcgacg agctgaccaa gaaccaggtg    1200

tccctgacat gtctggtgaa gggcttctat ccctccgaca tcgccgtgga gtgggagtct    1260

aatggccagc ctgagaacaa ttacaagacc acaccccctg tgctggactc cgatggctct    1320

ttctttctgt attctaagct gaccgtggat aagagcagat ggcagcaggg caacgtgttc    1380

agctgttccg tgatgcacga agcactgcac aaccactaca ctcagaaatc cctgtcactg    1440

tcacctggca agtgataa                                                  1458




<210> 33
<211> 2232
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/anti-PSMA

<400> 33
ttaagaaaaa atacgggtag aagcagtttg agagctccgt tcgccaccat ggagtttgga      60

ctgagttggg tgttcctggt cgccctgttt agaggcgtgc agtgtgaagt gcagctggtg     120

cagagcggcc ctgaagtgaa aaagccaggc gccaccgtga agatctcttg caagacaagc     180

ggctacacct tcacagagta taccatccac tgggtgaagc aggcaccagg caagggcctg     240

gagtggatcg gcaacatcaa tcctaacaat ggcggcacca catacaacca gaagtttgag     300

gacaaggcca ccctgacagt ggacaagagc accgatacag cctatatgga gctgagctcc     360

ctgcggtccg aggacaccgc cgtgtactat tgcgccgccg gctggaattt cgattactgg     420

ggccagggca ccctgctgac agtgtctagc gccagcacaa agggaccatc cgtgtttcca     480

ctggcacctt cctctaagtc cacctctgga ggaacagccg ccctgggctg tctggtgaag     540

gattacttcc ctgagccagt gaccgtgtcc tggaactctg gcgccctgac ctccggagtg     600

cacacatttc cagccgtgct gcagagctcc ggcctgtaca gcctgtctag cgtggtgacc     660

gtgccttcct ctagcctggg cacccagaca tatatctgca acgtgaatca caagccatcc     720

aatacaaagg tggacaagcg ggtggagccc aagtcttgtg ataagaccca cacatgccca     780

ccttgtccag cacctgagct gctgggagga ccatccgtgt tcctgtttcc acccaagcct     840

aaggacaccc tgatgatctc tagaacccct gaggtgacat gcgtggtggt ggacgtgagc     900

cacgaggatc cagaggtgaa gttcaactgg tacgtggatg gcgtggaggt gcacaatgcc     960

aagaccaagc ctagggagga gcagtacaac tctacctatc gcgtggtgag cgtgctgaca    1020

gtgctgcacc aggactggct gaacggcaag gagtataagt gcaaggtgtc caataaggcc    1080

ctgccagccc ccatcgagaa gaccatcagc aaggcaaagg gacagccaag ggagccacag    1140

gtgtacacac tgcctccatc tagagacgag ctgaccaaga accaggtgag cctgacatgt    1200

ctggtgaagg gcttctatcc atccgacatc gccgtggagt gggagtctaa tggccagccc    1260

gagaacaatt acaagaccac accccctgtg ctggacagcg atggctcctt ctttctgtat    1320

agcaagctga ccgtggacaa gtccaggtgg cagcagggca acgtgtttag ctgctccgtg    1380

atgcacgagg ccctgcacaa tcactacaca cagaagtctc tgagcctgtc cccaggcaag    1440

aggagaaaga ggggatccgg agagggaagg ggctctctgc tgacctgtgg cgatgtggag    1500

gagaaccctg gcccaatgaa gtatctgctg cctacagcag ccgccggcct gctgctgctg    1560

gcagcacagc ctgccatggc cgacatccag atgacccagt ccccatcctc tctgtctaca    1620

agcgtgggcg atcgcgtgac cctgacatgc aaggcatccc aggacgtggg aaccgcagtg    1680

gattggtacc agcagaagcc cggccctagc ccaaagctgc tgatctattg tgccagcacc    1740

cggcacacag gcatcccatc cagattctcc ggctctggca gcggcaccga ctttaccctg    1800

acaatcatca gctccctgca gccagaggac ttcgcagcag attactattg ccagcagtac    1860

aatagctatc ctctgacctt tggcccaggc acaaaggtgg acatcaagag gaccgtggcc    1920

gcccctagcg tgttcatctt tccacccagc gatgagcagc tgaagtccgg cacagcctct    1980

gtggtgtgcc tgctgaacaa cttctaccca cgcgaggcca aggtgcagtg gaaggtggac    2040

aacgccctgc agtctggcaa tagccaggag tccgtgaccg agcaggactc taaggatagc    2100

acatattccc tgtctagcac cctgacactg agcaaggccg attacgagaa gcacaaggtg    2160

tatgcctgcg aggtcactca tcaggggctg tcatcaccag tcaccaaaag tttcaatagg    2220

ggggaatgtt ga                                                        2232




<210> 34
<211> 768
<212> DNA
<213> Artificial Sequence


<220> 
<223> transgenic construct/eGFP

<400> 34
ttaagaaaaa atacgggtag aattggagcg gccgcattgt gccaagatgg tgagcaaggg      60

cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg     120

ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct     180

gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct     240

gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt     300

caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg     360

caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga     420

gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa     480

ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa     540

cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca     600

gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca     660

gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt     720

gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaga                  768




<210> 35
<211> 17430
<212> DNA
<213> Newcastle disease virus


<220> 
<223> Mut HN(F277L)/M(G165W)/F(F117S)/F(F190L)/F(L289A)/L(V757I)/L(F1551S)/L(R1700L)-Sofituzumab

<400> 35
accaaacaga gaatccgtga gatacgataa aaggcgaagg agcaatcgaa gtcgtacggg       60

tagaaggtgt gaatctcgag tgcgagaccg aagcttaaac tcgagagagc cttctgccaa      120

catgtcttcc gtatttgacg agtatgaaca gctcctcgcg gctcagactc gccctaatgg      180

agctcacgga ggaggagaga aggggagcac cttaaaagtt gaagtcccgg tattcactct      240

taacagtgac gacccagaag atagatggaa ctttgcagta ttctgtctta ggattgctgt      300

tagcgaagat gccaacaaac cactcagaca aggtgctctc atatctctct tatgctccca      360

ttctcaagtg atgaggaacc atgtcgccct tgcagggaaa cagaatgagg ccacactggc      420

tgttcttgag atcgatggtt tcaccaacag cgtgcctcaa tttaacaaca ggagtggagt      480

gtctgaggag agagcacaga gattcttgat gatagcaggg tccctccctc gggcatgcag      540

caacggtacc ccgttcatca cagctggggt tgaagatgat gcaccagaag acatcactga      600

tactctggaa agaatcatct ctatccaggc tcaagtatgg gtcacggtag caaaggccat      660

gactgcatat gagacagcgg atgagtcgga aacaagaaga atcaataagt atatgcagca      720

aggcagagtc caaaagaagt acatcctcca ccccgtatgt aggagcgcaa ttcaactcac      780

gattagacaa tctctggcag tccgcatttt cttggttagc gagcttaaga gaggccgcaa      840

cacggcaggt ggaagttcca cttattatag cttggtaggg gacatagact catacatcag      900

gaacaccggg cttactgcat tcttcctgac actcaggtat ggaattaaca ccaagacatc      960

agcccttgca ctcagcagcc tcgcaggcga tatccaaaaa atgaagcagc tcatgcgtct     1020

atatcggatg aaaggagata atgcgccgta catgacactg ctcggtgaca gtgaccagat     1080

gagctttgca ccggctgagt atgcacaact ctactctttt gcaatgggta tggcatccgt     1140

cctagacaaa ggaactggca agtaccagtt cgccagagac tttatgagca catcattctg     1200

gagacttgga gtagagtatg ctcgggctca gggaagcagc atcaatgagg atatggctgc     1260

cgagctaaag ctgaccccag cggcaaggag gggcctggca gctgctgccc aacgagcgtc     1320

cgaggagacc ggcagcatgg acattcccac tcaacaagct ggggtcctca cagggctcag     1380

cgacggaggc cctcaagccc cacaaggtgg actgaacagg tcgcaagggc aaccggacgc     1440

cggagatggg gagacccaat ttttagattt gatgagagca gtggcaaata gtatgagaga     1500

agcgccaaac tctgtgcaga acaccactca gcaggagcct ccatctactc ctgggccatc     1560

tcaagacaac gacaccgact ggggatactg accgacaaca ctcagcctgc ctccatcgaa     1620

ttatctcgat tcttctgcct gtaacctaac ccctggtcca cagtctcaca cggccaaacc     1680

cgcaaacgag cccccccctc tctccccccc cctccagcca cacggctcca accgcccaaa     1740

acaacacggg cacaactcga ctcactcata atctacacag agccgaagat cttagaaaaa     1800

aatacgggta gaagagagac attcagagat caggacaaat catcagggtc tccgctctcc     1860

cctctaccca gcagaccaga gtgaagatgg ccaccttcac ggatgcagag atcgacgatc     1920

tatttgaaac cagtggaact gtcattgaca gcataattac ggcccaaggc aacccagtag     1980

agactgttgg aaggagcgca atcccacaag gcaaaactaa agcattgagt gcagcatggg     2040

agaaacatgg aagcacccaa ccgccggccg gccaagacac ccctgatcga atggacagat     2100

cagacaaaca accatcccca cccgaacagg caaccacaca caacagcccg ccagccacat     2160

ccaccgacca gccccccacc caggccgcag gcgaagccgg tgacacacag ctcaagactg     2220

gagcaagcaa ctccctcctg tcgatgctcg acaagcttag caataaatcg tccaatgcta     2280

aaaagggccc acggtcgagt ccccaggaag ggcaccacca acctccgacc cagcagcaag     2340

ggagtcaaca gagccgcgga aacagtcagg agagatcgca aaaccaggtc aaggccgcct     2400

ctggagacca gggcacagac gcgaacacag catatcatgg acaatggaag gagtcacaac     2460

catcagctgg tgcaatccct catgctctcc ggtcagggca gagccaagcc aatactcctg     2520

catctgtgga tcatgtccag ctacctgtcg actttgtgca ggcgatgatg tctatgatgg     2580

aggcgatatc acagaaggta aataaagtcg actatcagct agaccttgtc tcaaagcaga     2640

catcctccat ccccatgatg cgatctgaaa tccaacagct gaaaacatcc gttgcggtca     2700

tggaagccaa cctgggcatg atgaagattc tggaccctgg ttgtgctaac gtttcatctt     2760

taagtgacct acgggcggtc gcccgctctc acccagtttt agtttcaggc cccggagacc     2820

catctcctta tgtgacacaa gggggtgaat tgatactcaa taaactctcg caaccagtgc     2880

aacatccttc tgagttgatt aaacctgcca cgataagcgg gcctgatata ggagtggaga     2940

aggacactgt ccgtgcattg atcacctcac gcccaatgca tccgagctct tcagctaagc     3000

tcctgagtaa gctggatgca gccgggtcga tagaagaaat taggaaaatc aaacgccttg     3060

cgctgaatgg ctgatcacta ctacaacccg caacgggttc ccgtttatct attgtcacaa     3120

ggaacccgcc ccgaagctta agaaaaaata cgggtagaag cagtttgaga gctccgttcg     3180

ccaccatgga gtttgggctg tcctgggtgt tcctggtcgc tctgtttagg ggggtgcagt     3240

gtgaagtgca gctggtcgtc gagtccgggg ggggcctggt gcagccagga ggcagcctga     3300

ggctgtcctg cgcagcatcc ggctactcta tcaccaacga ctatgcctgg aattgggtga     3360

gacaggcacc aggcaagggc ctggagtggg tgggctacat ctcttatagc ggctacacca     3420

catataaccc cagcctgaag tccaggttca ccatctctcg cgataccagc aagaacacac     3480

tgtacctgca gatgaattcc ctgagggcag aggacaccgc cgtgtactat tgcgccagat     3540

ggacaagcgg cctggattat tggggccagg gcaccctggt gacagtgagc tccgccagca     3600

ccaagggccc ttccgtgttt cccctggccc cttctagcaa gtccacctct ggaggaacag     3660

ccgccctggg ctgtctggtg aaggactact tccctgagcc agtgaccgtg tcttggaaca     3720

gcggcgccct gacctccgga gtgcacacat ttcccgccgt gctgcagtcc tctggcctgt     3780

acagcctgag ctccgtggtg accgtgcctt ctagctccct gggcacccag acatatatct     3840

gcaacgtgaa tcacaagcca tccaatacaa aggtggacaa gcgggtggag cccaagtctt     3900

gtgataagac ccacacatgc ccaccttgtc cagcacctga gctgctggga ggaccatccg     3960

tgttcctgtt tccacccaag cctaaggaca ccctgatgat cagcagaacc ccagaggtga     4020

catgcgtggt ggtggacgtg tcccacgagg atcccgaggt gaagttcaac tggtacgtgg     4080

atggcgtgga ggtgcacaat gccaagacca agcccaggga ggagcagtac aactctacct     4140

atcgcgtggt gagcgtgctg acagtgctgc accaggactg gctgaacggc aaggagtaca     4200

agtgcaaggt gtctaataag gccctgccag cccccatcga gaagaccatc agcaaggcaa     4260

agggacagcc aagggagcca caggtgtaca cactgcctcc atctcgcgac gagctgacca     4320

agaaccaggt gagcctgaca tgtctggtga agggcttcta tcccagcgac atcgccgtgg     4380

agtgggagtc caatggccag cctgagaaca attacaagac cacaccccct gtgctggact     4440

ccgatggctc tttctttctg tatagcaagc tgaccgtgga taagtcccgg tggcagcagg     4500

gcaacgtgtt tagctgctcc gtgatgcacg aggccctgca caatcactac acacagaagt     4560

ctctgagcct gtccccaggc aagaggagaa agaggggatc cggcgagggc agaggctctc     4620

tgctgacctg tggcgacgtg gaggagaacc ctggcccaat gaagtatctg ctgcctacag     4680

cagccgccgg cctgctgctg ctggcagcac agcctgccat ggccgacatc cagatgaccc     4740

agtccccatc tagcctgtct gccagcgtgg gcgacagggt gaccatcaca tgcaaggcca     4800

gcgatctgat ccacaattgg ctggcctggt accagcagaa gcctggcaag gccccaaagc     4860

tgctgatcta tggagccacc tctctggaga caggagtgcc aagccgcttc tccggatctg     4920

gaagcggcac cgactttacc ctgacaatct cctctctgca gcctgaggat ttcgccacat     4980

actattgcca gcagtactgg accacaccat tcacctttgg ccagggcaca aaggtggaga     5040

tcaagaggac cgtggccgcc ccttccgtgt tcatctttcc accctctgac gagcagctga     5100

agtccggcac agcctctgtg gtgtgcctgc tgaacaactt ctacccacgc gaggccaagg     5160

tgcagtggaa ggtggataac gccctgcaga gcggcaattc ccaggagtct gtgaccgagc     5220

aggacagcaa ggattccaca tattctctga gctccaccct gacactgagc aaggccgact     5280

acgagaagca caaggtgtat gcctgtgaag tcacccacca ggggctgtca tcaccagtca     5340

ctaagagttt caatcggggg gaatgctgag ctgaccgagc cctcctctat aaacccaaga     5400

ttcaaggctc caagcgataa ccttctcccg cctcttccat cccactgaat gatcgcgcag     5460

ctgcaattaa tctagcaaca ttaaagatta agaaaaaata cgggtagaat cggagtgcac     5520

cgattgtgcc aagatggact catctaggac aattgggtta tactttgatt ctgcccttcc     5580

ttctagcaac ctgttagcat tcccgattgt cttacgagat gtaggagatg gaaagaagca     5640

aattactccg caatatagga tccggcgtct tgactcgtgg acagacagta aagaagactc     5700

ggtattcatc actacctacg gattcatctt ccaggttggg aatgaagaag tcactgtcgg     5760

catgatcaat gataatccca agcgagagtt actctccgct gcgatgctct gcctaggaag     5820

cgtcccgaat gttggagatc ctgttgagct ggcaagggcc tgcctcacta tggtggtaac     5880

atgcaagaag agtgcaacta atactgagag aatggtcttc tcagtagtgc aggcaccccg     5940

ggtgctgcaa agctgtaggg tcgtggcaga caaatactcg tcagtgaatg cagttaagca     6000

cgtgaaagca ccagagaaga tcccttggag tgaaacccta gagtacaagg tgaattttgt     6060

ctctttgact gtggtgccga agaaggatgt ctacaagatc ccaaccgcag tattgaaggt     6120

atccggctcg agcctgtata atcttgcgct caatgtcact attgatgtgg aggtagaccc     6180

aaagagcccg ttagtcaagt ccctttctag gtccgacagt ggatactatg ctaatctctt     6240

cttacatatc ggacttatgt ccactgtaga taagagggga aagaaagtga catttgacca     6300

gctggagagg aagataagga gacttgatct atctgtcggg ctcagtgatg tgctcggacc     6360

ttctgtgctt gtgaaggcga gaggtgcacg gactaggctg ctggcacctt tcttctctaa     6420

cagcgggaca gcctgctacc ctatagcaaa tgcctctcct caggtagcta agatactctg     6480

gagtcagacc gcgtgcctgc ggagtgtaaa aatcattatt caagcgggca cccaacgcgc     6540

tgtcgcagtg actgctgacc atgaggttac ctctactaag atagagaaga ggcataccat     6600

cgctaaatac aatcccttca agaaataggc cgtatccctg agactgcaat tcacccgcct     6660

tcccaaaaca ccatgacacc agataatgat ctgtcttgat tacttacagt tagtttccct     6720

gtctatcaaa ttagaaaaaa cacgggtaga agagttcgga tcccggccgg cgcaccaaaa     6780

gcgcaagatg ggccccagat cttctaccag gatcccagta cctctaatgc tgaccatacg     6840

gatcacgctg gcactgagtt atgtccgtct gacaagttct cttgatggca ggcctcttgc     6900

agccgcaggg atcgtggtaa caggggataa agcagttaac atatacacct catcccagac     6960

agggtcaatc atagtcaagt tactcccaaa tatgcccaag gacaaagagg catgtgcaaa     7020

agccccattg gaggcttaca acaggacact gactactttg cttacccccc ttggtgattc     7080

tatccgcagg atacaagagt ctgtgactac atccggagga aggagacaga gacgctctat     7140

aggtgccatt attggcagtg tagctctagg ggttgcaaca gctgcacaga taacggcagc     7200

ctcggctctg atacaagcca accagaatgc tgctaacatc ctccggctta aggagagcat     7260

tgctgcaacc aatgaagctg tacacgaggt cactggcgga ttgtcacagt tagcagtggc     7320

agttggaaag atgcagcaat ttgttaatga ccagcttaat aacacagctc aagagttgga     7380

ctgtataaaa attacacagc aggttggtgt agaactcaac ttatacttaa ctgaattgac     7440

tacagtgttc gggccacaaa tcacttcccc tgccttaact cagttgactg ttcaggctct     7500

ttacaatctg gctggtggta atgtagatta cttgttgact aagttaggtg tagggaacaa     7560

ccagctcagc tcattgattg gtagcggctt gatcaccggt aaccctattt tttacgactc     7620

acagactcaa ctcttgggca tacaggtgac tgcaccctca gtcgggaacc taaataatat     7680

gcgtgccacc tacttggaga ccttgtctgt aagcacaaca aagggatttg cctcagcact     7740

tgtcccaaaa gtagtgacac aggtcggttc tgtgatagaa gagcttgaca cctcatactg     7800

tatagaagct gatttggatt tatattgtac aagaatagtg acattcccta tgtcccctgg     7860

tatttattcc tgtttgagcg gcaatacatc ggcttgcatg tattcaagga ctgaaggcgc     7920

acttactaca ccatacatga ctctcaaagg ctcagttgtt gccaattgcc agatgacaac     7980

atgtagatgt gcagaccccc cgggtatcat atcacaaaat tatggagagg ctgtgtctct     8040

aatagataag cactcatgca atgtcgtatc cttagacggg ataactttga ggctcagtgg     8100

ggaatttgat gcaacttatc aaaagaatat ctcaatatta gattctcaag tactagtgac     8160

aggcaatctc gatatctcaa ctgagcttgg gaatgtcaac cactcaataa gtaatgcttt     8220

ggataagtta gaggaaagca acagcaaact agacaaagtc aatgtcaaac tgaccagcac     8280

atctgctctc attacctata ttgttttaac tgtcatatct cttgttcttg gtatgcttag     8340

cctggttcta gcatgctatc tgatgtacaa gcaaaaagcg caacgaaaga ccttgttgtg     8400

gcttggaaat aataccctag atcagatgag agctactaca aaaatgtgaa tgcagatgag     8460

aggcagaggt atccccaata gcaatctgtg tgtcaattct ggcagcctgt taatcagaag     8520

aattaagaaa aaactaccgg atgtaggtga acaaaaggga atatacgggt agaacggcct     8580

gagaggccac ccctcaatcg ggagccaggc cccactacgt ccgctctacc gcatcaccaa     8640

cagcagtctt cagtcatgga cagcgcagtt agccaagttg cgctagagaa tgatagaaga     8700

gaagcgaata atacatggcg cttggttttc cggatcgcag ccttactttt actggtaata     8760

accttagccg tctctgcagt cgccctggca tatagtatgg aggctagcac acctggcgac     8820

cttgtaagca taccgactgc gatctctagg gcagaggaaa ggattacatc tgcactcggt     8880

tccaatcaag atgtagtaga taggatatac aagcaagtgg cccttgagtc tccattggca     8940

ctgctaaata ccgaatctat aattatgaat gcaataacgt ctctctctta tcaaatcaat     9000

ggagccacaa ataatagcgg gtgtggggca cctgttcatg acccagatta catcgggggg     9060

ataggtcaag aacttattgt agatgatacg agtgacgtca catcatttta tccctctgca     9120

ttccaagaac acctgaattt tatcccggcg cccactacag gatcaggctg cactcggata     9180

ccctcattcg acatgagtgc tacccattac tgttacactc acaatgtgat attgtctggc     9240

tgcagagatc actcacactc acatcagtat ttagcacttg gtgtgcttcg gacatctgca     9300

acagggaggg tattcttttc tactctgcgt tccatcaact tggatgacgc ccaaaatcgg     9360

aagtcttgca gtgtgagtgc aactccttta ggttgtgata tgctgtgctc taaaatcaca     9420

gagactgagg aagaggatta taaatcagtt atccccacat cgatggtaca tggaaggtta     9480

gggcttgacg gccaatacca tgagaaggac ctagacgtca caacactatt tagggactgg     9540

gtggcaaatt acccaggagt aggaggtggg tcttttatta acaatcgcgt atggttcccg     9600

gtctacggag ggctaaaacc cagctcgcct agtgacactg cacaagaagg gagatacgta     9660

atatacaagc gatacaatga cacatgcccg gatgagcaag attaccagat tcggatggct     9720

aagtcatcgt ataagcctag gcggtttggt ggaaaacgcg tacagcaggc catcctatcc     9780

atcaaggtgt caacatcctt gggtgaggac ccggtgttga ctgtaccgcc taatacggtc     9840

gcactcatgg gggccgaagg cagagttctc acagtgggga catctcattt cttatatcag     9900

cgagggtcat catacttctc tcccgctttg ttatacccta tgacagtcaa caacaaaaca     9960

gccactcttc ataatcctta tacattcaat gctttcactc ggccaggtag tgtcccttgc    10020

caggcttcag caagatgccc caactcatgt gttaccggag tctatactga tccatatccc    10080

ttagtcttcc ataggaacca caccttgcga ggggtattcg gaacaatgct tgatgacgaa    10140

caagcaagac tcaaccctgt atctgcagta tttgataaca tatcccgcag tcgcataact    10200

cgggtaagtt caagcagtac cagggcagca tacacgacat caacgtgttt taaagttgtc    10260

aagaccaata aaacctattg cctcagcatt gcagaaatat ccaataccct cttcggggaa    10320

ttcagaattg tccccttact agttgagatt ctcaaggatg gtggggttta agaagctagg    10380

aatggtcggt tgagtcaacc gtgagaaggc ggggaagatg atattgcatc atctatcttc    10440

tgtaacacca agaatcaaat cgaataccag tgcgagctcg aatcctacgc tgccagtcag    10500

ccataatcgg ctggtgctaa tgtggttagc ctgaatcttg tcgatagtca cttgattaag    10560

aaaaaatgtg gacggtagtg aaatataagg caaagcagct cacagaggac agcacgggta    10620

ggacatggcg ggctccggac ccgaaagggc agagcatcag attatcctac cagagtcaca    10680

tctgtcctca ccattggtca agcataaatt gctttattac tggaaattaa ctgggctacc    10740

gcttcctgac gaatgtgact tcgaccatct tattatcagc cgacaatgga agaaggtact    10800

tgaatcggcc acccctgaca ttgagagaat gataaaacta gggcgggcag tacaccagac    10860

tctcaaccac aattccagga taaccggagt actccatccc cggtgtttag aggaactggc    10920

tagtattgag gttcctgatt caaccaacaa atttcggaag atcgaaaaaa agatccagat    10980

tcacaacaca aggtatggag aactgttcac aagattatgc acgcatgtag aaaagaaact    11040

attggggtca tcttggtcta acaatgtccc acggtcagag gaattcaaca gcatccgtac    11100

agatccggca ttttggtttc actcaaaatg gtccacagcc aaatttgcat ggctccatat    11160

aaaacaggtc cagaggcatc tgattgtagc agcaagaaca aggtccgcag tcaacaaatt    11220

agtgacgctg acccataagg taggccaaat ctttgttact cctgagcttg tcattgtgac    11280

acatacagat gagaacaagt tcacgtgtct tacccaggaa cttgtgttga tgtatgcaga    11340

tatgatggag ggcagagata tggtcagcat aatatcatcc acggcggcac atcttaggag    11400

cttatcagag aaaattgatg atattctgcg gttagtagat gctctggcaa gagatttggg    11460

caatcaagtc tacgatgttg tagcactaat ggagggattc gcatacggcg ctgttcagct    11520

gcttgaaccg tcaggtacat ttgcggggga tttcttcgca ttcaacctgc aggagctcaa    11580

agatactcta accggactcc tccccaagga tatcgcagaa tctgtgactc acgcaatcgc    11640

aaccatattc tctggcttag aacaaaatca agcagctgag atgttgtgcc tgttgcgtct    11700

gtggggtcac ccactactcg agtcccgtat tgcagcaaaa gcagttagga gtcaaatgtg    11760

cgcaccaaaa atggtagact ttgatatgat cctccaggta ttatctttct ttaaaggaac    11820

aatcatcaat ggatatagaa agaagaatgc aggcgtgtgg ccacgtgtca agatagatac    11880

gatatacggg aaggtcatag ggcagctaca cgcagattct gcagagattt cacatgatgt    11940

catgttgagg gaatacaaga gtttatctgc acttgaattc gagccatgta tagagtatga    12000

ccctgtcacc aatctgagca tgtttttaaa agacaaggca atcgcacacc cgaaagacaa    12060

ctggctcgct tcgtttaggc gaaaccttct ctctgaggac cagaagaaac atgtaagaga    12120

ggcaacctca actaaccgcc tcttgataga gttcttagag tcaaatgatt ttgatccata    12180

taaagagatg gaatatctga cgacccttga gtacctaaga gatgataatg tggcagtatc    12240

atactcactc aaagaaaaag aggtgaaagt taatgggcgg attttcgcaa agctaacaaa    12300

tagattaagg aattgtcagg taatggcaga agggatccta gctgaccaga ttgcaccttt    12360

cttccaggga aatggggtca ttcaggatag catatctttg actaaaagta tgctagcgat    12420

gagtcaactg tctttcaaca gcaacaagaa acgtattact gactgcaaag aaagagtatc    12480

ctcaaaccgc aatcatgatc cgaagagcaa gaatcgtcgg agagttgcca cttttgtaac    12540

taccgacctg caaaagtatt gtctcaattg gagatatcag acagtcaagc tgttcgctca    12600

tgccatcaat cagctgatgg gcttacctca cttcttcgag tggattcatc ttagactaat    12660

ggatactacg atgtttgtag gggacccttt caatcctcca agtgacccta cggactgtga    12720

tctatcaaga gtcccaaatg atgacatata tattgtcagt gctaggggag gcattgaggg    12780

attatgccag aagctatgga caatgatctc aattgctgca atccagcttg ctgcagcaag    12840

atcacattgt cgcgttgcct gtatggtaca aggcgacaat caagtaatag ctataacgag    12900

agaggtaaga tcagatgact ccccagagat ggtgttaaca caattgcatc aagccagtga    12960

taatttcttc aaggaattga ttcatgtcaa tcatttgatc ggccataatt tgaaggatcg    13020

tgaaaccatc aggtcagaca cgttcttcat atacagcaaa cgaatattca aagatggagc    13080

aatactcagt caggtcctca aaaactcatc taaattagtg ctaatatcag gcgaccttag    13140

tgaaaacact gtaatgtctt gtgccaacat tgcatctact gtagcacggt tatgcgagaa    13200

cgggcttcct aaggatttct gttattactt aaactactta atgagttgcg tgcagacata    13260

cttcgattcc gaattttcca tcaccaacaa ctcgcaactc gattctaacc agtcgtggat    13320

agaggacatt tcttttgtgc actcatatgt cctgacccct gctcaactgg ggggactgag    13380

taaccttcaa tactcaaggc tctacacaag gaacatcggc gacccgggaa ccactgcttt    13440

cgcagagatc aagagattag aggcagtggg gttactgagt cctagcatta tgactaacat    13500

cttaactagg ccgcctggaa atggagattg ggccagtctg tgcaacgatc catactcctt    13560

taattttgag actgtcgcaa gcccaaatat tgtccttaag aaacatacac aaagagtcct    13620

atttgaaact tgctcgaatc ccttattatc tggagtgcac acagaggata atgaggcaga    13680

agagaaggca ttggctgaat tcttgctcaa tcaagaaatg attcatccac gtgtcgcgca    13740

tgctatcatg gaagcaagct ctgtaggtag gagaaagcaa attcaggggc ttgttgacac    13800

aacaaacacc gtgattaaga ttgcactgac taggaggcca ctcggcatca agaggctgat    13860

gcggatagtc aattactcga gcatgcatgc aatgctattt agagatgatg ttttctcgtc    13920

taatagatcc aaccatccct tagtctcttc tgatatgtgt tctcagacac tggcagacta    13980

tgcacggaac agaagctggt cacctttgac agggggtaga aaaatactgg gtgtatctaa    14040

tcctgatacc atagaacttg tagagggtga gatccttagt gtcagtggag ggtgcactag    14100

atgtgacagt ggggatgaac agtttacttg gttccatctt ccaagcaata tagagctaaa    14160

cgatgacacc agcaagaatc ctccaatgag agtgccatat ctcgggtcaa agactcaaga    14220

gaggagagcc gcctcgcttg cgaaaatagc tcatatgtca ccacacgtga aggcggctct    14280

aagggcgtca tctgtgttaa tctgggctta tggggacaac gaaataaact ggactgctgc    14340

ccttaagatt gcaaggtctc ggtgcaacat aagctcagag tatcttcgac tattgtcacc    14400

cttgcctaca gctgggaatc tccaacatag attggacgac ggcataactc agatgacatt    14460

cacccctgca tctctataca gggtgtcacc ttacattcat atatctaatg attctcaaag    14520

gctatttact gaagaaggag tcaaagaggg gaatgtggtt tatcagcaaa tcatgctctt    14580

gggtttgtcc ttaattgagt cactcttccc aatgacaaca accaagacat atgatgaaat    14640

cacattgcac ctccacagta aatttagctg ctgtatcagg gaagcacctg ttgcagttcc    14700

tttcgagcta ctcggggtgg caccggaact aagggcagta acctcaaata agtttatgta    14760

tgatcctagc cctgtatcag agggagactt tgcgagactt gacttagcta tctttaagag    14820

ttatgaactt aatttagagt catattccac aatagagcta atgaacgttc tttcaatatc    14880

tagtgggaag ttgattggcc agtctgtggt ttcttatgat gaagatacct ccataaagaa    14940

tgacgctata atagtgtatg acaacacacg gaattggatc agcgaagctc agaattcaga    15000

tgtggtccgc ctattcgagt atgcggcact cgaagtgctc ctcgactgtt cttatcaact    15060

ctactatctg agagtaagag gcctaaacaa tatcgtcctg tacatgagtg atttatacaa    15120

gaatatgcca ggaattctac tctctaatat tgcagccaca atatctcacc ctgtcatcca    15180

ttcaaggttg aatgcagtag gtctggtcaa ccatgacggg tcacaccaac ttgcagacac    15240

agatttcatt gaaatgtctg caaagctgct agtctcttgc actcgacgcg tggtctcagg    15300

tttacatgca gggaataagt atgacctgct gtttccatct gtcttggatg ataacctaag    15360

tgagaagatg cttcagttga tatcccaatt atgctgtctg tatacggtgc tctttgctac    15420

aacaagagaa atcccgaaaa taagaggctt atctgcagaa gagaaatgtt cagtacttac    15480

tgagtaccta ctgtcagatg ctgtgaaacc gttacttggg tccgagcaag tgagctctat    15540

catgtctccc aacatagtta cgttcccagc caatctgtat tacatgtcta ggaagagcct    15600

taatttgatc agggagagag aggacaggga tactatcttg gcattgttgt tccctcaaga    15660

accgctgctc gagtttcctc tggtacgaga tattggtgct cgtgtaaaag atccatttac    15720

cctacaacct gcggcgtttt tacaagagtt agatttgagt gctccggcaa ggtatgacgc    15780

attcacaatc agtcaggcgc attctgaaca catattgcca aacccagagg aagatcactt    15840

agtacgatac ttgttcagag gaatagggac tgcgtcctcc tcttggtata aggcatccca    15900

tcttctttct gtacccgagg tcagatgtgc aaggcatggg aactccttat atttagcaga    15960

aggaagtgga gccatcatga gtcttctcga attgcatata ccacacgaaa ctatctatta    16020

caatacactt ttctcgaacg agatgaaccc cccacagcga catttcggac caactccaac    16080

acagtttctg aattcggttg tttttaggaa tttacaggcg gaagtaccat gcaaggatgg    16140

atttgtccag gagttccgtc cgttatggag agagaataca gaagaaagcg atctgacctc    16200

agataaagca gtgggatata tcacatctgt agtgccgtac aggtctgtat cattgctgca    16260

ttgtgacatt gaaatccctc caggatctaa tcaaagctta ctagatcagc tggctaccaa    16320

tctgtctctg attgccatgc attctgtgaa ggagggcggg gtcgtgatta tcaaagtact    16380

gtatgcaatg ggatattact tccatctact catgaacttg tttactccat gttccacgaa    16440

aggatatatt ctctctaatg gctatgcctg tagaggggat atggagtgtt acctgatatt    16500

tgtcatgggc tacctaggcg ggcctacatt tgtacatgag gtggtgagga tggcaaaaac    16560

gctagtacag cggcatggca cacttttgtc taagtcagat gagattacac tgactaggtt    16620

atttacttca cagcaacagc gtgtaacaga catcctatcc agccctttac cgagactaat    16680

gaagtacttg agagagaata ttgatactgc actgattgaa gccgggggac agcctgtccg    16740

tccattctgt gcagagagtt tagtgagcac actaacagac atgactcaga caacccagat    16800

catcgccagc cacattgata cagtcattcg atctgtgatc tatatggaag cagagggtga    16860

tcttgctgac acagtattct tatttacccc ttacaacctc tctatggacg ggaaaaagag    16920

aacatcactt aaacagtgca caagacagat cttagaggtc acaatactgg gtctcagagt    16980

caaaaatctc aataaagtag gtgatgtaat cagcctagta ctcagaggta tgatttctct    17040

ggaggacctt ctcccactga gaacctactt gaagtgtagt acctgcccta agtatttgaa    17100

ggctgtccta ggtattacca aactcaaaga aatgttcaca gacgcctctt tattatactt    17160

gactcgtgct caacaaaaat tctacatgaa aactataggc aatgcagtca agggatacta    17220

tagtaactgt gactcttaaa ggcaaccaca tatcaatagg ccctctttct agccgatcgt    17280

attcttgttg acttcattat accatattag aaaaaaattg aattccgacc ctttaagact    17340

cgtattcgga ttcaaataat tatctcagaa aaaaagtgca cgtagttgtt cttgattata    17400

gtcccgtcat tcaccaagtc tttgtttggt                                     17430




<210> 36
<211> 571
<212> PRT
<213> Newcastle disease virus


<220> 
<223> HN protein

<400> 36
Met Asp Ser Ala Val Ser Gln Val Ala Leu Glu Asn Asp Arg Arg Glu 
1               5                   10                  15      
Ala Asn Asn Thr Trp Arg Leu Val Phe Arg Ile Ala Ala Leu Leu Leu 
            20                  25                  30          
Leu Val Ile Thr Leu Ala Val Ser Ala Val Ala Leu Ala Tyr Ser Met 
        35                  40                  45              
Glu Ala Ser Thr Pro Gly Asp Leu Val Ser Ile Pro Thr Ala Ile Ser 
    50                  55                  60                  
Arg Ala Glu Glu Arg Ile Thr Ser Ala Leu Gly Ser Asn Gln Asp Val 
65                  70                  75                  80  
Val Asp Arg Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Ala Leu 
                85                  90                  95      
Leu Asn Thr Glu Ser Ile Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         
Gln Ile Asn Gly Ala Thr Asn Asn Ser Gly Cys Gly Ala Pro Val His 
        115                 120                 125             
Asp Pro Asp Tyr Ile Gly Gly Ile Gly Gln Glu Leu Ile Val Asp Asp 
    130                 135                 140                 
Thr Ser Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Gln Glu His Leu 
145                 150                 155                 160 
Asn Phe Ile Pro Ala Pro Thr Thr Gly Ser Gly Cys Thr Arg Ile Pro 
                165                 170                 175     
Ser Phe Asp Met Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         
Leu Ser Gly Cys Arg Asp His Ser His Ser His Gln Tyr Leu Ala Leu 
        195                 200                 205             
Gly Val Leu Arg Thr Ser Ala Thr Gly Arg Val Phe Phe Ser Thr Leu 
    210                 215                 220                 
Arg Ser Ile Asn Leu Asp Asp Ala Gln Asn Arg Lys Ser Cys Ser Val 
225                 230                 235                 240 
Ser Ala Thr Pro Leu Gly Cys Asp Met Leu Cys Ser Lys Ile Thr Glu 
                245                 250                 255     
Thr Glu Glu Glu Asp Tyr Lys Ser Val Ile Pro Thr Ser Met Val His 
            260                 265                 270         
Gly Arg Leu Gly Leu Asp Gly Gln Tyr His Glu Lys Asp Leu Asp Val 
        275                 280                 285             
Thr Thr Leu Phe Arg Asp Trp Val Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 
Gly Ser Phe Ile Asn Asn Arg Val Trp Phe Pro Val Tyr Gly Gly Leu 
305                 310                 315                 320 
Lys Pro Ser Ser Pro Ser Asp Thr Ala Gln Glu Gly Arg Tyr Val Ile 
                325                 330                 335     
Tyr Lys Arg Tyr Asn Asp Thr Cys Pro Asp Glu Gln Asp Tyr Gln Ile 
            340                 345                 350         
Arg Met Ala Lys Ser Ser Tyr Lys Pro Arg Arg Phe Gly Gly Lys Arg 
        355                 360                 365             
Val Gln Gln Ala Ile Leu Ser Ile Lys Val Ser Thr Ser Leu Gly Glu 
    370                 375                 380                 
Asp Pro Val Leu Thr Val Pro Pro Asn Thr Val Ala Leu Met Gly Ala 
385                 390                 395                 400 
Glu Gly Arg Val Leu Thr Val Gly Thr Ser His Phe Leu Tyr Gln Arg 
                405                 410                 415     
Gly Ser Ser Tyr Phe Ser Pro Ala Leu Leu Tyr Pro Met Thr Val Asn 
            420                 425                 430         
Asn Lys Thr Ala Thr Leu His Asn Pro Tyr Thr Phe Asn Ala Phe Thr 
        435                 440                 445             
Arg Pro Gly Ser Val Pro Cys Gln Ala Ser Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 
Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Val Phe His Arg 
465                 470                 475                 480 
Asn His Thr Leu Arg Gly Val Phe Gly Thr Met Leu Asp Asp Glu Gln 
                485                 490                 495     
Ala Arg Leu Asn Pro Val Ser Ala Val Phe Asp Asn Ile Ser Arg Ser 
            500                 505                 510         
Arg Ile Thr Arg Val Ser Ser Ser Ser Thr Arg Ala Ala Tyr Thr Thr 
        515                 520                 525             
Ser Thr Cys Phe Lys Val Val Lys Thr Asn Lys Thr Tyr Cys Leu Ser 
    530                 535                 540                 
Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 
Leu Leu Val Glu Ile Leu Lys Asp Gly Gly Val 
                565                 570     




<210> 37
<211> 364
<212> PRT
<213> Newcastle disease virus


<220> 
<223> M protein

<400> 37
Met Asp Ser Ser Arg Thr Ile Gly Leu Tyr Phe Asp Ser Ala Leu Pro 
1               5                   10                  15      
Ser Ser Asn Leu Leu Ala Phe Pro Ile Val Leu Arg Asp Val Gly Asp 
            20                  25                  30          
Gly Lys Lys Gln Ile Thr Pro Gln Tyr Arg Ile Arg Arg Leu Asp Ser 
        35                  40                  45              
Trp Thr Asp Ser Lys Glu Asp Ser Val Phe Ile Thr Thr Tyr Gly Phe 
    50                  55                  60                  
Ile Phe Gln Val Gly Asn Glu Glu Val Thr Val Gly Met Ile Asn Asp 
65                  70                  75                  80  
Asn Pro Lys Arg Glu Leu Leu Ser Ala Ala Met Leu Cys Leu Gly Ser 
                85                  90                  95      
Val Pro Asn Val Gly Asp Pro Val Glu Leu Ala Arg Ala Cys Leu Thr 
            100                 105                 110         
Met Val Val Thr Cys Lys Lys Ser Ala Thr Asn Thr Glu Arg Met Val 
        115                 120                 125             
Phe Ser Val Val Gln Ala Pro Arg Val Leu Gln Ser Cys Arg Val Val 
    130                 135                 140                 
Ala Asp Lys Tyr Ser Ser Val Asn Ala Val Lys His Val Lys Ala Pro 
145                 150                 155                 160 
Glu Lys Ile Pro Trp Ser Glu Thr Leu Glu Tyr Lys Val Asn Phe Val 
                165                 170                 175     
Ser Leu Thr Val Val Pro Lys Lys Asp Val Tyr Lys Ile Pro Thr Ala 
            180                 185                 190         
Val Leu Lys Val Ser Gly Ser Ser Leu Tyr Asn Leu Ala Leu Asn Val 
        195                 200                 205             
Thr Ile Asp Val Glu Val Asp Pro Lys Ser Pro Leu Val Lys Ser Leu 
    210                 215                 220                 
Ser Arg Ser Asp Ser Gly Tyr Tyr Ala Asn Leu Phe Leu His Ile Gly 
225                 230                 235                 240 
Leu Met Ser Thr Val Asp Lys Arg Gly Lys Lys Val Thr Phe Asp Gln 
                245                 250                 255     
Leu Glu Arg Lys Ile Arg Arg Leu Asp Leu Ser Val Gly Leu Ser Asp 
            260                 265                 270         
Val Leu Gly Pro Ser Val Leu Val Lys Ala Arg Gly Ala Arg Thr Arg 
        275                 280                 285             
Leu Leu Ala Pro Phe Phe Ser Asn Ser Gly Thr Ala Cys Tyr Pro Ile 
    290                 295                 300                 
Ala Asn Ala Ser Pro Gln Val Ala Lys Ile Leu Trp Ser Gln Thr Ala 
305                 310                 315                 320 
Cys Leu Arg Ser Val Lys Ile Ile Ile Gln Ala Gly Thr Gln Arg Ala 
                325                 330                 335     
Val Ala Val Thr Ala Asp His Glu Val Thr Ser Thr Lys Ile Glu Lys 
            340                 345                 350         
Arg His Thr Ile Ala Lys Tyr Asn Pro Phe Lys Lys 
        355                 360                 




<210> 38
<211> 553
<212> PRT
<213> Newcastle disease virus

<220> 
<223> F protein 

<220> 
<221> misc_feature 
<222> (190)..(190)
<223> Xaa can be Phe or Leu

<220> 
<221> misc_feature 
<222> (289)..(289)
<223> Xaa can be Leu or Ala

<400> 38
Met Gly Pro Arg Ser Ser Thr Arg Ile Pro Val Pro Leu Met Leu Thr 
1               5                   10                  15      
Ile Arg Ile Thr Leu Ala Leu Ser Tyr Val Arg Leu Thr Ser Ser Leu 
            20                  25                  30          
Asp Gly Arg Pro Leu Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              
Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  
Leu Leu Pro Asn Met Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  
Leu Glu Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      
Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Arg 
            100                 105                 110         
Arg Gln Arg Arg Ser Ile Gly Ala Ile Ile Gly Ser Val Ala Leu Gly 
        115                 120                 125             
Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ser Ala Leu Ile Gln Ala 
    130                 135                 140                 
Asn Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 
Thr Asn Glu Ala Val His Glu Val Thr Gly Gly Leu Ser Gln Leu Ala 
                165                 170                 175     
Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Xaa Asn Asn 
            180                 185                 190         
Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Thr Gln Gln Val Gly Val 
        195                 200                 205             
Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 
Ile Thr Ser Pro Ala Leu Thr Gln Leu Thr Val Gln Ala Leu Tyr Asn 
225                 230                 235                 240 
Leu Ala Gly Gly Asn Val Asp Tyr Leu Leu Thr Lys Leu Gly Val Gly 
                245                 250                 255     
Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         
Pro Ile Phe Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             
Xaa Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 
Thr Leu Ser Val Ser Thr Thr Lys Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 
Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     
Tyr Cys Ile Glu Ala Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         
Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             
Ala Cys Met Tyr Ser Arg Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 
Thr Leu Lys Gly Ser Val Val Ala Asn Cys Gln Met Thr Thr Cys Arg 
385                 390                 395                 400 
Cys Ala Asp Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     
Ser Leu Ile Asp Lys His Ser Cys Asn Val Val Ser Leu Asp Gly Ile 
            420                 425                 430         
Thr Leu Arg Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             
Ser Ile Leu Asp Ser Gln Val Leu Val Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 
Thr Glu Leu Gly Asn Val Asn His Ser Ile Ser Asn Ala Leu Asp Lys 
465                 470                 475                 480 
Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     
Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Val Ile Ser Leu 
            500                 505                 510         
Val Leu Gly Met Leu Ser Leu Val Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             
Gln Lys Ala Gln Arg Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 
Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             




<210> 39
<211> 2204
<212> PRT
<213> Newcastle disease virus


<220> 
<223> L protein

<220> 
<221> misc_feature 
<222> (1717)..(1717)
<223> Xaa can be Tyr or His 

<220> 
<221> misc_feature 
<222> (1910)..(1910)
<223> Xaa can be Glu or Lys


<400> 39
Met Ala Gly Ser Gly Pro Glu Arg Ala Glu His Gln Ile Ile Leu Pro 
1               5                   10                  15      
Glu Ser His Leu Ser Ser Pro Leu Val Lys His Lys Leu Leu Tyr Tyr 
            20                  25                  30          
Trp Lys Leu Thr Gly Leu Pro Leu Pro Asp Glu Cys Asp Phe Asp His 
        35                  40                  45              
Leu Ile Ile Ser Arg Gln Trp Lys Lys Val Leu Glu Ser Ala Thr Pro 
    50                  55                  60                  
Asp Ile Glu Arg Met Ile Lys Leu Gly Arg Ala Val His Gln Thr Leu 
65                  70                  75                  80  
Asn His Asn Ser Arg Ile Thr Gly Val Leu His Pro Arg Cys Leu Glu 
                85                  90                  95      
Glu Leu Ala Ser Ile Glu Val Pro Asp Ser Thr Asn Lys Phe Arg Lys 
            100                 105                 110         
Ile Glu Lys Lys Ile Gln Ile His Asn Thr Arg Tyr Gly Glu Leu Phe 
        115                 120                 125             
Thr Arg Leu Cys Thr His Val Glu Lys Lys Leu Leu Gly Ser Ser Trp 
    130                 135                 140                 
Ser Asn Asn Val Pro Arg Ser Glu Glu Phe Asn Ser Ile Arg Thr Asp 
145                 150                 155                 160 
Pro Ala Phe Trp Phe His Ser Lys Trp Ser Thr Ala Lys Phe Ala Trp 
                165                 170                 175     
Leu His Ile Lys Gln Val Gln Arg His Leu Ile Val Ala Ala Arg Thr 
            180                 185                 190         
Arg Ser Ala Val Asn Lys Leu Val Thr Leu Thr His Lys Val Gly Gln 
        195                 200                 205             
Ile Phe Val Thr Pro Glu Leu Val Ile Val Thr His Thr Asp Glu Asn 
    210                 215                 220                 
Lys Phe Thr Cys Leu Thr Gln Glu Leu Val Leu Met Tyr Ala Asp Met 
225                 230                 235                 240 
Met Glu Gly Arg Asp Met Val Ser Ile Ile Ser Ser Thr Ala Ala His 
                245                 250                 255     
Leu Arg Ser Leu Ser Glu Lys Ile Asp Asp Ile Leu Arg Leu Val Asp 
            260                 265                 270         
Ala Leu Ala Arg Asp Leu Gly Asn Gln Val Tyr Asp Val Val Ala Leu 
        275                 280                 285             
Met Glu Gly Phe Ala Tyr Gly Ala Val Gln Leu Leu Glu Pro Ser Gly 
    290                 295                 300                 
Thr Phe Ala Gly Asp Phe Phe Ala Phe Asn Leu Gln Glu Leu Lys Asp 
305                 310                 315                 320 
Thr Leu Thr Gly Leu Leu Pro Lys Asp Ile Ala Glu Ser Val Thr His 
                325                 330                 335     
Ala Ile Ala Thr Ile Phe Ser Gly Leu Glu Gln Asn Gln Ala Ala Glu 
            340                 345                 350         
Met Leu Cys Leu Leu Arg Leu Trp Gly His Pro Leu Leu Glu Ser Arg 
        355                 360                 365             
Ile Ala Ala Lys Ala Val Arg Ser Gln Met Cys Ala Pro Lys Met Val 
    370                 375                 380                 
Asp Phe Asp Met Ile Leu Gln Val Leu Ser Phe Phe Lys Gly Thr Ile 
385                 390                 395                 400 
Ile Asn Gly Tyr Arg Lys Lys Asn Ala Gly Val Trp Pro Arg Val Lys 
                405                 410                 415     
Ile Asp Thr Ile Tyr Gly Lys Val Ile Gly Gln Leu His Ala Asp Ser 
            420                 425                 430         
Ala Glu Ile Ser His Asp Val Met Leu Arg Glu Tyr Lys Ser Leu Ser 
        435                 440                 445             
Ala Leu Glu Phe Glu Pro Cys Ile Glu Tyr Asp Pro Val Thr Asn Leu 
    450                 455                 460                 
Ser Met Phe Leu Lys Asp Lys Ala Ile Ala His Pro Lys Asp Asn Trp 
465                 470                 475                 480 
Leu Ala Ser Phe Arg Arg Asn Leu Leu Ser Glu Asp Gln Lys Lys His 
                485                 490                 495     
Val Arg Glu Ala Thr Ser Thr Asn Arg Leu Leu Ile Glu Phe Leu Glu 
            500                 505                 510         
Ser Asn Asp Phe Asp Pro Tyr Lys Glu Met Glu Tyr Leu Thr Thr Leu 
        515                 520                 525             
Glu Tyr Leu Arg Asp Asp Asn Val Ala Val Ser Tyr Ser Leu Lys Glu 
    530                 535                 540                 
Lys Glu Val Lys Val Asn Gly Arg Ile Phe Ala Lys Leu Thr Asn Arg 
545                 550                 555                 560 
Leu Arg Asn Cys Gln Val Met Ala Glu Gly Ile Leu Ala Asp Gln Ile 
                565                 570                 575     
Ala Pro Phe Phe Gln Gly Asn Gly Val Ile Gln Asp Ser Ile Ser Leu 
            580                 585                 590         
Thr Lys Ser Met Leu Ala Met Ser Gln Leu Ser Phe Asn Ser Asn Lys 
        595                 600                 605             
Lys Arg Ile Thr Asp Cys Lys Glu Arg Val Ser Ser Asn Arg Asn His 
    610                 615                 620                 
Asp Pro Lys Ser Lys Asn Arg Arg Arg Val Ala Thr Phe Val Thr Thr 
625                 630                 635                 640 
Asp Leu Gln Lys Tyr Cys Leu Asn Trp Arg Tyr Gln Thr Val Lys Leu 
                645                 650                 655     
Phe Ala His Ala Ile Asn Gln Leu Met Gly Leu Pro His Phe Phe Glu 
            660                 665                 670         
Trp Ile His Leu Arg Leu Met Asp Thr Thr Met Phe Val Gly Asp Pro 
        675                 680                 685             
Phe Asn Pro Pro Ser Asp Pro Thr Asp Cys Asp Leu Ser Arg Val Pro 
    690                 695                 700                 
Asn Asp Asp Ile Tyr Ile Val Ser Ala Arg Gly Gly Ile Glu Gly Leu 
705                 710                 715                 720 
Cys Gln Lys Leu Trp Thr Met Ile Ser Ile Ala Ala Ile Gln Leu Ala 
                725                 730                 735     
Ala Ala Arg Ser His Cys Arg Val Ala Cys Met Val Gln Gly Asp Asn 
            740                 745                 750         
Gln Val Ile Ala Ile Thr Arg Glu Val Arg Ser Asp Asp Ser Pro Glu 
        755                 760                 765             
Met Val Leu Thr Gln Leu His Gln Ala Ser Asp Asn Phe Phe Lys Glu 
    770                 775                 780                 
Leu Ile His Val Asn His Leu Ile Gly His Asn Leu Lys Asp Arg Glu 
785                 790                 795                 800 
Thr Ile Arg Ser Asp Thr Phe Phe Ile Tyr Ser Lys Arg Ile Phe Lys 
                805                 810                 815     
Asp Gly Ala Ile Leu Ser Gln Val Leu Lys Asn Ser Ser Lys Leu Val 
            820                 825                 830         
Leu Ile Ser Gly Asp Leu Ser Glu Asn Thr Val Met Ser Cys Ala Asn 
        835                 840                 845             
Ile Ala Ser Thr Val Ala Arg Leu Cys Glu Asn Gly Leu Pro Lys Asp 
    850                 855                 860                 
Phe Cys Tyr Tyr Leu Asn Tyr Leu Met Ser Cys Val Gln Thr Tyr Phe 
865                 870                 875                 880 
Asp Ser Glu Phe Ser Ile Thr Asn Asn Ser Gln Leu Asp Ser Asn Gln 
                885                 890                 895     
Ser Trp Ile Glu Asp Ile Ser Phe Val His Ser Tyr Val Leu Thr Pro 
            900                 905                 910         
Ala Gln Leu Gly Gly Leu Ser Asn Leu Gln Tyr Ser Arg Leu Tyr Thr 
        915                 920                 925             
Arg Asn Ile Gly Asp Pro Gly Thr Thr Ala Phe Ala Glu Ile Lys Arg 
    930                 935                 940                 
Leu Glu Ala Val Gly Leu Leu Ser Pro Ser Ile Met Thr Asn Ile Leu 
945                 950                 955                 960 
Thr Arg Pro Pro Gly Asn Gly Asp Trp Ala Ser Leu Cys Asn Asp Pro 
                965                 970                 975     
Tyr Ser Phe Asn Phe Glu Thr Val Ala Ser Pro Asn Ile Val Leu Lys 
            980                 985                 990         
Lys His Thr Gln Arg Val Leu Phe Glu Thr Cys Ser Asn Pro Leu Leu 
        995                 1000                1005            
Ser Gly Val His Thr Glu Asp Asn Glu Ala Glu Glu Lys Ala Leu Ala 
    1010                1015                1020                
Glu Phe Leu Leu Asn Gln Glu Met Ile His Pro Arg Val Ala His Ala 
1025                1030                1035                1040
Ile Met Glu Ala Ser Ser Val Gly Arg Arg Lys Gln Ile Gln Gly Leu 
                1045                1050                1055    
Val Asp Thr Thr Asn Thr Val Ile Lys Ile Ala Leu Thr Arg Arg Pro 
            1060                1065                1070        
Leu Gly Ile Lys Arg Leu Met Arg Ile Val Asn Tyr Ser Ser Met His 
        1075                1080                1085            
Ala Met Leu Phe Arg Asp Asp Val Phe Ser Ser Asn Arg Ser Asn His 
    1090                1095                1100                
Pro Leu Val Ser Ser Asp Met Cys Ser Gln Thr Leu Ala Asp Tyr Ala 
1105                1110                1115                1120
Arg Asn Arg Ser Trp Ser Pro Leu Thr Gly Gly Arg Lys Ile Leu Gly 
                1125                1130                1135    
Val Ser Asn Pro Asp Thr Ile Glu Leu Val Glu Gly Glu Ile Leu Ser 
            1140                1145                1150        
Val Ser Gly Gly Cys Thr Arg Cys Asp Ser Gly Asp Glu Gln Phe Thr 
        1155                1160                1165            
Trp Phe His Leu Pro Ser Asn Ile Glu Leu Asn Asp Asp Thr Ser Lys 
    1170                1175                1180                
Asn Pro Pro Met Arg Val Pro Tyr Leu Gly Ser Lys Thr Gln Glu Arg 
1185                1190                1195                1200
Arg Ala Ala Ser Leu Ala Lys Ile Ala His Met Ser Pro His Val Lys 
                1205                1210                1215    
Ala Ala Leu Arg Ala Ser Ser Val Leu Ile Trp Ala Tyr Gly Asp Asn 
            1220                1225                1230        
Glu Ile Asn Trp Thr Ala Ala Leu Lys Ile Ala Arg Ser Arg Cys Asn 
        1235                1240                1245            
Ile Ser Ser Glu Tyr Leu Arg Leu Leu Ser Pro Leu Pro Thr Ala Gly 
    1250                1255                1260                
Asn Leu Gln His Arg Leu Asp Asp Gly Ile Thr Gln Met Thr Phe Thr 
1265                1270                1275                1280
Pro Ala Ser Leu Tyr Arg Val Ser Pro Tyr Ile His Ile Ser Asn Asp 
                1285                1290                1295    
Ser Gln Arg Leu Phe Thr Glu Glu Gly Val Lys Glu Gly Asn Val Val 
            1300                1305                1310        
Tyr Gln Gln Ile Met Leu Leu Gly Leu Ser Leu Ile Glu Ser Leu Phe 
        1315                1320                1325            
Pro Met Thr Thr Thr Lys Thr Tyr Asp Glu Ile Thr Leu His Leu His 
    1330                1335                1340                
Ser Lys Phe Ser Cys Cys Ile Arg Glu Ala Pro Val Ala Val Pro Phe 
1345                1350                1355                1360
Glu Leu Leu Gly Val Ala Pro Glu Leu Arg Ala Val Thr Ser Asn Lys 
                1365                1370                1375    
Phe Met Tyr Asp Pro Ser Pro Val Ser Glu Gly Asp Phe Ala Arg Leu 
            1380                1385                1390        
Asp Leu Ala Ile Phe Lys Ser Tyr Glu Leu Asn Leu Glu Ser Tyr Ser 
        1395                1400                1405            
Thr Ile Glu Leu Met Asn Val Leu Ser Ile Ser Ser Gly Lys Leu Ile 
    1410                1415                1420                
Gly Gln Ser Val Val Ser Tyr Asp Glu Asp Thr Ser Ile Lys Asn Asp 
1425                1430                1435                1440
Ala Ile Ile Val Tyr Asp Asn Thr Arg Asn Trp Ile Ser Glu Ala Gln 
                1445                1450                1455    
Asn Ser Asp Val Val Arg Leu Phe Glu Tyr Ala Ala Leu Glu Val Leu 
            1460                1465                1470        
Leu Asp Cys Ser Tyr Gln Leu Tyr Tyr Leu Arg Val Arg Gly Leu Asn 
        1475                1480                1485            
Asn Ile Val Leu Tyr Met Ser Asp Leu Tyr Lys Asn Met Pro Gly Ile 
    1490                1495                1500                
Leu Leu Ser Asn Ile Ala Ala Thr Ile Ser His Pro Val Ile His Ser 
1505                1510                1515                1520
Arg Leu Asn Ala Val Gly Leu Val Asn His Asp Gly Ser His Gln Leu 
                1525                1530                1535    
Ala Asp Thr Asp Phe Ile Glu Met Ser Ala Lys Leu Leu Val Ser Cys 
            1540                1545                1550        
Thr Arg Arg Val Val Ser Gly Leu His Ala Gly Asn Lys Tyr Asp Leu 
        1555                1560                1565            
Leu Phe Pro Ser Val Leu Asp Asp Asn Leu Ser Glu Lys Met Leu Gln 
    1570                1575                1580                
Leu Ile Ser Gln Leu Cys Cys Leu Tyr Thr Val Leu Phe Ala Thr Thr 
1585                1590                1595                1600
Arg Glu Ile Pro Lys Ile Arg Gly Leu Ser Ala Glu Glu Lys Cys Ser 
                1605                1610                1615    
Val Leu Thr Glu Tyr Leu Leu Ser Asp Ala Val Lys Pro Leu Leu Gly 
            1620                1625                1630        
Ser Glu Gln Val Ser Ser Ile Met Ser Pro Asn Ile Val Thr Phe Pro 
        1635                1640                1645            
Ala Asn Leu Tyr Tyr Met Ser Arg Lys Ser Leu Asn Leu Ile Arg Glu 
    1650                1655                1660                
Arg Glu Asp Arg Asp Thr Ile Leu Ala Leu Leu Phe Pro Gln Glu Pro 
1665                1670                1675                1680
Leu Leu Glu Phe Pro Leu Val Arg Asp Ile Gly Ala Arg Val Lys Asp 
                1685                1690                1695    
Pro Phe Thr Leu Gln Pro Ala Ala Phe Leu Gln Glu Leu Asp Leu Ser 
            1700                1705                1710        
Ala Pro Ala Arg Xaa Asp Ala Phe Thr Ile Ser Gln Ala His Ser Glu 
        1715                1720                1725            
His Ile Leu Pro Asn Pro Glu Glu Asp His Leu Val Arg Tyr Leu Phe 
    1730                1735                1740                
Arg Gly Ile Gly Thr Ala Ser Ser Ser Trp Tyr Lys Ala Ser His Leu 
1745                1750                1755                1760
Leu Ser Val Pro Glu Val Arg Cys Ala Arg His Gly Asn Ser Leu Tyr 
                1765                1770                1775    
Leu Ala Glu Gly Ser Gly Ala Ile Met Ser Leu Leu Glu Leu His Ile 
            1780                1785                1790        
Pro His Glu Thr Ile Tyr Tyr Asn Thr Leu Phe Ser Asn Glu Met Asn 
        1795                1800                1805            
Pro Pro Gln Arg His Phe Gly Pro Thr Pro Thr Gln Phe Leu Asn Ser 
    1810                1815                1820                
Val Val Phe Arg Asn Leu Gln Ala Glu Val Pro Cys Lys Asp Gly Phe 
1825                1830                1835                1840
Val Gln Glu Phe Arg Pro Leu Trp Arg Glu Asn Thr Glu Glu Ser Asp 
                1845                1850                1855    
Leu Thr Ser Asp Lys Ala Val Gly Tyr Ile Thr Ser Val Val Pro Tyr 
            1860                1865                1870        
Arg Ser Val Ser Leu Leu His Cys Asp Ile Glu Ile Pro Pro Gly Ser 
        1875                1880                1885            
Asn Gln Ser Leu Leu Asp Gln Leu Ala Thr Asn Leu Ser Leu Ile Ala 
    1890                1895                1900                
Met His Ser Val Lys Xaa Gly Gly Val Val Ile Ile Lys Val Leu Tyr 
1905                1910                1915                1920
Ala Met Gly Tyr Tyr Phe His Leu Leu Met Asn Leu Phe Thr Pro Cys 
                1925                1930                1935    
Ser Thr Lys Gly Tyr Ile Leu Ser Asn Gly Tyr Ala Cys Arg Gly Asp 
            1940                1945                1950        
Met Glu Cys Tyr Leu Ile Phe Val Met Gly Tyr Leu Gly Gly Pro Thr 
        1955                1960                1965            
Phe Val His Glu Val Val Arg Met Ala Lys Thr Leu Val Gln Arg His 
    1970                1975                1980                
Gly Thr Leu Leu Ser Lys Ser Asp Glu Ile Thr Leu Thr Arg Leu Phe 
1985                1990                1995                2000
Thr Ser Gln Gln Gln Arg Val Thr Asp Ile Leu Ser Ser Pro Leu Pro 
                2005                2010                2015    
Arg Leu Met Lys Tyr Leu Arg Glu Asn Ile Asp Thr Ala Leu Ile Glu 
            2020                2025                2030        
Ala Gly Gly Gln Pro Val Arg Pro Phe Cys Ala Glu Ser Leu Val Ser 
        2035                2040                2045            
Thr Leu Thr Asp Met Thr Gln Thr Thr Gln Ile Ile Ala Ser His Ile 
    2050                2055                2060                
Asp Thr Val Ile Arg Ser Val Ile Tyr Met Glu Ala Glu Gly Asp Leu 
2065                2070                2075                2080
Ala Asp Thr Val Phe Leu Phe Thr Pro Tyr Asn Leu Ser Met Asp Gly 
                2085                2090                2095    
Lys Lys Arg Thr Ser Leu Lys Gln Cys Thr Arg Gln Ile Leu Glu Val 
            2100                2105                2110        
Thr Ile Leu Gly Leu Arg Val Lys Asn Leu Asn Lys Val Gly Asp Val 
        2115                2120                2125            
Ile Ser Leu Val Leu Arg Gly Met Ile Ser Leu Glu Asp Leu Leu Pro 
    2130                2135                2140                
Leu Arg Thr Tyr Leu Lys Cys Ser Thr Cys Pro Lys Tyr Leu Lys Ala 
2145                2150                2155                2160
Val Leu Gly Ile Thr Lys Leu Lys Glu Met Phe Thr Asp Ala Ser Leu 
                2165                2170                2175    
Leu Tyr Leu Thr Arg Ala Gln Gln Lys Phe Tyr Met Lys Thr Ile Gly 
            2180                2185                2190        
Asn Ala Val Lys Gly Tyr Tyr Ser Asn Cys Asp Ser 
        2195                2200                




<210> 40
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 40
acgactcact ataggaccaa acagagaatc cgtgag                               36




<210> 41
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 41
ccgggaagat ccagggcact cttcttgcat gttac                                35




<210> 42
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 42
gggcctgcct cactatggtg gtaacatgca agaag                                35




<210> 43
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 43
tgcatgttac caccaatgtg tcattgtatc gcttg                                35





<210> 44
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 44
caagaaggga gatacgtaat atacaagcga tacaatg                              37




<210> 45
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 45
tcgcttgtat attacttgtt gtagcaaaga gcacc                                35




<210> 46
<211> 38
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 46
ggcctggatc ttcccattat gctgtctgta tacggtgc                             38




<210> 47
<211> 38
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 47
atgccatgcc gacccaccaa acaaagactt ggtgaatg                             38




<210> 48
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 48
cctatagtga gtcgtattaa tttc                                           24




<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 49
cctggatctt cccgggtcgg                                                20




<210> 50
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 50
gggtcggcat ggcatctcca cc                                             22




<210> 51
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 51
gggaagatcc aggcctatag tg                                             22




<210> 52
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 52
ctctagagtc gacccttctg ccaacatgtc ttccg                                35




<210> 53
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 53
gggaagcggc cgcccgtcgg tcagtatccc cagtc                                35




<210> 54
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 54
ctctagagtc gaccccagag tgaagatggc caccttc                              37




<210> 55
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 55
gggaagcggc cgcccgtagt agtgatcagc cattc                                35




<210> 56
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 56
ctctagagtc gacccgggta ggacatggcg ggctc                                35




<210> 57
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 57
gggaagcggc cgccctgcct ttaagagtca cagttac                              37



<210> 58
<211> 3854
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 L1

<400> 58
gctacacgtt ccacgacaat gtcatccatg atactgactc agtttggacc gttcattgag       60

agcatttcag gtatcactga tcaatcgaat gacgtgtttg aagatgcagc aaaagcattc      120

tctatgttta ctcgcagcga tgtctacaag gcgctggatg aaataccttt ctctgatgat      180

gcgatgcttc caatccctcc aactatatat acgaaaccat ctcacgattc atattattac      240

attgatgctc taaaccgtgt gcgtcgcaaa acatatcagg gccctgatga cgtgtacgta      300

cctaattgtt ctattgttga attgctggag ccacatgaga ctctgacatc ttatgggcgg      360

ttgtccgagg ccatcgagaa tcgtgccaag gatggggaca gccaagccag aatcgccaca      420

acgtatggta gaatcgctga atctcaagct cgacagatta aggctccatt ggagaagttt      480

gtgttggcac tattagtggc cgaagcaggg gggtctttat atgatccagt tttgcagaag      540

tatgatgaga ttccagatct atcgcataat tgccctttat ggtgttttag agagatctgt      600

cgtcacatat ctggtccatt accagatcgg gcaccttatc tttacttatc tgcaggggtt      660

ttctggttaa tgtcaccacg aatgacgtct gcaatccctc cgctactatc cgatcttgtt      720

aatttagcta ttttgcaaca aactgcgggt ttagatccat cattagtgaa attgggagta      780

cagatatgcc ttcatgcagc agctagctca agttatgcat ggtttatctt aaagactaag      840

tctatttttc ctcaaaacac gttgcacagt atgtatgaat ctctagaagg gggatactgt      900

cctaatcttg aatggttaga gcctagatca gactataagt tcatgtacat gggagtcatg      960

ccattgtccg ctaagtatgc taggtcggcg ccgtccaatg ataagaaagc gcgggaactt     1020

ggcgagaaat atggactgag ctcagtcgtc ggtgagcttc gtaaacggac aaagacgtat     1080

gttaaacatg actttgcttc agtgaggtac attcgtgacg ctatggcatg tactagcggt     1140

attttcttgg taagaacacc caccgaaacg gtattgcaag aatatacgca gagtccggag     1200

attaaggttc ccattcccca gaaagactgg acaggcccaa taggtgaaat cagaattcta     1260

aaagatacaa caagttccat cgcgcgttac ttatatagaa catggtactt ggcagcggcg     1320

agaatggcgg ctcaaccacg tacgtgggat ccattgtttc aagcgattat gagatctcaa     1380

tacgtgacag ctaggggtgg atctggcgca gcactccgcg aatctttgta tgcaatcaat     1440

gtgtcgttac ctgatttcaa gggcttacca gtgaaggcag caactaagat attccaggcg     1500

gcacaattag cgaacttgcc gttctcccac acatcagtgg ctatactagc tgacacttca     1560

atgggattgc gaaatcaggt gcagaggcgg ccacgatcca ttatgccatt aaatgtgccc     1620

cagcagcagg tttcggcgcc ccatacattg acagcggatt acattaacta ccacatgaat     1680

ctatcaacca cgtctggtag tgcggtcatt gagaaggtga ttcctttagg tgtatacgct     1740

tcgagccctc ctaaccagtc gatcaacatt gacatatctg cgtgtgacgc tagtattact     1800

tgggatttct ttctgtcagt gattatggcg gctatacacg aaggtgtcgc tagtagctcc     1860

attggaaaac catttatggg ggttcctgca tccattgtaa atgatgagtc tgtcgttgga     1920

gtgagagctg ctaggccgat atcgggaatg cagaacatga ttcagcatct atcgaaacta     1980

tataaacgtg gattttcata tagagtaaac gattcttttt ctccaggtaa cgattttact     2040

catatgacta ccactttccc gtcaggttca acagccacct ctactgagca tactgctaat     2100

aatagtacga tgatggaaac tttcctgaca gtatggggac ccgaacatac tgacgaccct     2160

gacgtcttac gtttaatgaa gtctttaact attcaaagga attacgtatg tcaaggtgat     2220

gatggattaa tgattatcga tgggactact gctggtaagg tgaacagtga aactattcag     2280

aagatgctag aattaatctc aaaatatggt gaggaattcg gatggaaata tgacatagcg     2340

tacgatggga ctgccgaata cttaaagcta tacttcatat ttggctgtcg aattccaaat     2400

cttagtcgcc atccaatcgt ggggaaagaa cgggcgaatt cttcagcaga ggagccatgg     2460

ccagcaattc tagatcagat tatgggtgtc ttctttaatg gtgttcatga tgggttacag     2520

tggcagcggt ggatacgtta ttcatgggct ctatgctgtg ctttctcacg tcaaagaaca     2580

atgattggtg agagcgtggg ttaccttcaa tatcctatgt ggtcttttgt ctactgggga     2640

ttaccactgg ttaaagcgtt tgggtcagac ccatggatat tttcttggta catgcctact     2700

ggagatctgg gaatgtatag ttggattagc ttgatacgcc ctctgatgac aagatggatg     2760

gtggctaatg gttacgtaac tgacagatgc tcacccgtat tcgggaacgc agattatcgc     2820

aggtgtttca atgaacttaa actatatcaa ggttattata tggcacaatt gcccaggaat     2880

cctaagaagt ctggacgagc ggcccctcgg gaggtaagag aacaattcac tcaggcatta     2940

tccgactatc taatgcaaaa tccagagctg aagtcacgtg tgctacgtgg tcgtagtgag     3000

tgggagaaat atggagcggg gataattcac aatcctccgt cattattcga tgtgccccat     3060

aaatggtatc agggtgcgca agaggcagca atcgctacga gagaagagct ggcagaaatg     3120

gatgagacat taatgcgcgc tcgaaggcac agctattcga gcttttcaaa gttattagag     3180

gcgtatctgc tcgtgaaatg gcgaatgtgc gaggcccgcg aaccgtcggt tgatttgcga     3240

ttaccattat gtgcgggtat tgacccatta aactcagatc cttttctcaa gatggtaagc     3300

gttggaccaa tgctccagag tacgagaaag tactttgctc agacactatt catggcaaag     3360

acggtgtcgg gtcttgacgt taacgcgatt gatagcgcgt tattacgact gcgaacatta     3420

ggtgctgata agaaagcatt aacggcgcag ttattaatgg tggggcttca ggagtcagaa     3480

gcggacgcat tggccgggaa gataatgcta caggatgtga atactgtgca attagccaga     3540

gtggttaact tagctgtgcc agatacttgg atgtcgttag actttgactc tatgttcaaa     3600

caccacgtca agctgcttcc caaagatgga cgtcatctaa atactgatat tcctcctcga     3660

atgggatggt tacgggccat tttacgattc ttaggtgccg gaatggtaat gactgcgact     3720

ggagttgctg tcgacatcta tctggaggat atacatggcg gtggtcggtc acttggacag     3780

agattcatga cttggatgcg acaggaagga cggtcagcgt gagtctacca tgggtcgtgg     3840

tgcgtcaact catc                                                       3854


<210> 59
<211> 3916
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 L2

<400> 59
gctaaatggc gcgatggcga acgtttgggg ggtgagactt gcagactcgt tatcttcacc       60

cactattgag acacgaacgc gtcagtatac cttacacgat ctttgctcag acctagatgc      120

taatccgggg agggaaccgt ggaaacctct gcgtaatcag cgtactaata atattgtggc      180

tgtgcaatta ttcagaccat tgcagggttt agttttagat acccagcttt atggatttcc      240

aggagcattt gatgactggg agcgattcat gagagagaag ctgcgtgtgc taaagtatga      300

agtattgcgc atctatccaa tcagcaacta tagcaatgaa catgtcaacg tcttcgtggc      360

caatgctttg gtgggcgctt tcctgtcgaa tcaagctttc tatgacctgc taccgttgtt      420

gataattaat gacactatga ttggtgatct acttggcacg ggggcatcgc tatcacagtt      480

ctttcaatct catggagatg tgctggaagt cgcagctggt cgtaagtatc tgcagatgga      540

aaactactcc aacgatgacg atgatcctcc attatttgcg aaagacctgt cagattatgc      600

taaagcattc tacagtgaca catatgaagt gttggacagg ttcttttgga cgcatgactc      660

ttcagcgggg gtcttagtgc attatgataa gccaacgaat ggtcatcact atctgctggg      720

tactttgact cagatggtca gtgcacctcc ttatattatt aacgctactg acgcaatgtt      780

gcttgaatcc tgtctagaac agttctcagc taatgtgcgt gcgagacctg cgcaacccgt      840

tacacgctta gaccaatgct atcatttaag atggggagca caatatgtag gagaagattc      900

actgacatat cggttggggg tgttatcctt gctggctacc aatggatatc aattagctag      960

accgattcca agacagttga cgaatcgatg gttgtcgagc tttgtgagtc aaattatgtc     1020

tgacggcgtc aacgagactc cactgtggcc ccaagaaagg tatgtgcaga tcgcttatga     1080

ttcaccatcc gttgttgatg gggctacgca atatggctat gtcaggaaga atcaactcag     1140

actcggcatg agaatatcgg cgctgcaatc gctgagtgat acgccctcgc cggtacagtg     1200

gcttccacaa tacaccatcg accaggcagc gatggacgaa ggcgatctga tggttagtcg     1260

gcttacgcaa ctcccgttac gtcctgatta tggtaatatc tgggtcggcg atgcgctatc     1320

ctattatgtg gactacaatc ggagtcatcg agtcgtgctt tcatcggaac ttcctcagct     1380

tccggacaca tattttgatg gcgatgaaca gtatgggcgc agcctgttct cactagctcg     1440

taagattggt gaccgctcgt tagtgaaaga tacggctgtc ttgaagcacg cttaccaagc     1500

catcgatcca aatactggta aggagtatct gagatctggg caatctgtcg catattttgg     1560

tgcatcagcg ggtcattctg gtgccgacca gccgttagtc atagagccct ggattcaagg     1620

gaaaatcagt ggtgtgccgc caccctcctc agtgcgacag ttcggctatg atgttgcccg     1680

tggcgcgatc gtcgatctgg cgagaccatt tccttctgga gattatcaat ttgtctattc     1740

ggatgttgac caggtggtcg atggccatga cgatctgagt atatcatctg gactggtgga     1800

gagccttttg tcttcatgca tgcacgccac agcacccggg ggctcatttg ttgttaagat     1860

aaattttccg actagacccg tatggcacta catcgaacag aagatcttgc ccaatattac     1920

gtcatacatg ttgatcaagc ctttcgtcac caacaacgtc gaattgttct tcgtcgcttt     1980

cggtgtgcat caacactcat cacttacttg gacatctgga gtgtacttct tcttggtgga     2040

ccatttttat cgttatgaga ctttatctac gatctcacga caattgccgt cttttgggta     2100

tgttgatgat gggtcttccg tgactggtat cgagacaatt agtattgaga accctggctt     2160

ctcgaatatg acccaggccg ctcgcattgg tatctcagga ttgtgtgcta atgtaggtaa     2220

cgcgcgtaag tccattgcca tttacgaatc ccatggggcc agagtattaa ctatcacatc     2280

aaggagatct ccggcatcag ctagaagaaa gtctaggttg cgatatttgc cattaataga     2340

ccctaggtcg ttagaggtac aggcgcgcac tattctgcca gctgatccag tgttatttga     2400

aaacgtgagc ggagcgtcac cccatgtttg tctgacaatg atgtacaact tcgaagtgtc     2460

gtcagcggta tatgatggag acgttgtgct agatcttggg acgggaccag aggctaaaat     2520

ccttgaactg atacccgcaa cctctccagt cacatgcgtg gacatacggc ctacagcgca     2580

gcctagtgga tgttggaacg ttcgtaccac gttccttgag ttagattatt tgagcgatgg     2640

atggatcact ggggtgcgtg gggacatagt tacttgtatg ttatctttgg gggccgctgc     2700

cgctggaaaa tcaatgactt ttgacgctgc gtttcagcaa ttaatcaaag tattatccaa     2760

gagtacggct aatgttgtgc tggtgcaggt taactgccct acagacgtgg tgaggagcat     2820

taagggctac ctagagatag attcgactaa caagaggtat aggttcccca aatttggtcg     2880

agacgagccg tactctgaca tggatgcgct ggagaaaata tgtcgtaccg cctggccaaa     2940

ctgctcaatt acctgggttc cattgtcata cgacttgcgg tggactagac tggcattatt     3000

agagtccacg acattgagta gcgcgtcgat tagaattgct gagctgatgt ataaatacat     3060

gcctattatg aggattgata ttcatggact acccatggaa aagcgaggta acttcatagt     3120

ggggcagaac tgctcattag taatccctgg ttttaatgcg caggatgtct ttaactgtta     3180

tttcaattcc gccctcgctt tctcgactga agatgtcaat gctgcgatga ttccccaagt     3240

gtctgcgcag tttgatgcga ctaagggtga gtggacgttg gatatggtct tatccgacgc     3300

aggaatctat accatgcagg ctctagtggg atctaatgct aatccagtct ctttgggttc     3360

ctttgtagtt gattctccag atgtagatat aactgacgct tggccagctc agttagactt     3420

tacgatcgcg ggaactgatg tcgatataac agttaatcct tattaccgtc tgatgacctt     3480

tgtaaggatc gatggacagt ggcagattgc caatccagac aaatttcaat tcttttcgtc     3540

ggcgtctggg acgttagtga tgaacgtcaa attagatatc gcagataaat atctactata     3600

ctatatacga gatgtccagt ctcgagatgt tggcttttac attcagcatc cacttcaact     3660

tttgaatacg atcacattgc caaccaacga ggaccttttt ctgagcgcac ctgacatgcg     3720

agagtgggca gttaaggaaa gcggtaacac gatatgtata ctcaatagtc aagggtttgt     3780

gctacctcaa gattgggatg tgttaacaga taccataagt tggtccccat cgatacccac     3840

atacattgtg ccaccgggtg attatacctt gactcctctg taactcactg tccctcgtga     3900

gcgcgcctaa ttcatc                                                     3916


<210> 60
<211> 3901
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 L3

<400> 60
gctaatcgtc aggatgaagc ggattccaag gaagacaaag ggcaaatcca gcggaaaggg       60

caatgactca acagagagag cggacgatgg ctcgagccaa ttaagagaca agcaaaacaa      120

taaggctggc cccgccacta cggagcctgg cacatccaac cgagagcaat acaaagctcg      180

accaggtatt gcatctgtgc agagggccac tgaaagtgca gaaatgccca tgaagaataa      240

tgacgaaggg acgccagata agaaaggaaa tactaagggc gacctagtta atgagcatag      300

tgaggctaaa gacgaggcgg atgaagcgac gaagaagcag gcaaaggata cagacaaaag      360

taaagcgcaa gtcacatatt cagacactgg tatcaataat gctaatgaac tgtcaagatc      420

tgggaatgtg gataatgagg gtggaagtaa tcagaagccg atgtctacca gaatagctga      480

ggcaacgtct gctatagtgt cgaaacatcc tgcgcgtgtt gggctgccac ctaccgctag      540

cagtggtcat gggtatcagt gccatgtctg ttctgcagtc ctgtttagtc ctttagacct      600

agatgcccac gtcgcctcac atggtttgca tggtaacatg acattaacat cgagtgatat      660

ccagcgacat ataactgagt tcatcagctc atggcaaaat catcctattg ttcaagtttc      720

ggctgatgtc gaaaataaga aaactgctca attgcttcac gctgacactc ctcgactcgt      780

cacttgggat gctggtttgt gtacttcatt caaaatcgtc ccgattgtgc cagctcaggt      840

gccgcaggat gtactggcct atacgttttt cacctcttca tacgctatcc aatcgccgtt      900

tccagaggcg gcagtgtcta ggattgtggt gcatacgaga tgggcatcta atgttgactt      960

tgaccgagac tcgtctgtca tcatggcgcc acctacagaa aacaatatcc atttgtttaa     1020

acagttacta aatactgaaa ccctgtctgt aaggggggct aatccgctaa tgttcagggc     1080

gaatgtgttg catatgttgc tagagttcgt attagataac ttgtatctga acagacatac     1140

gggattctct caagaccaca cgccatttac tgagggtgct aatttgcgtt cacttcctgg     1200

ccccgatgct gagaaatggt actcgattat gtatccaacg cgcatgggaa cgccgaatgt     1260

atccaaaata tgtaatttcg tcgcctcttg tgtgcgaaat cgggttggac ggtttgatcg     1320

agcacagatg atgaacggag ctatgtcaga gtgggtggat gtcttcgaga cttcagacgc     1380

gctaaccgtc tccattcgag gtcgatggat ggctagacta gctcgcatga acataaatcc     1440

aacagagatc gaatgggcat tgactgaatg tgcacaagga tatgtgactg tcacaagtcc     1500

ttacgctcct agcgtaaata gattgatgcc ctatcgtatc tccaacgctg agcggcaaat     1560

atcacagata atcaggatca tgaacattgg caataacgcg acggtgatac aacctgttct     1620

gcaagatatt tcggtactcc ttcaacgcat atcaccactc caaatagatc caactattat     1680

ttccaacact atgtcaacag tctcggagtc tactactcag accctcagcc ccgcgtcctc     1740

aattttgggt aaactacgac caagcaactc agatttttct agttttagag tcgcgttggc     1800

tggatggctt tataatgggg ttgtgacgac ggtgattgat gatagttcat atccaaaaga     1860

cggcggcagc gtgacctcac ttgaaaatct gtgggatttc ttcatccttg cgcttgctct     1920

accactgaca actgacccct gtgcacctgt gaaagcattc atgaccctag ccaacatgat     1980

ggttggtttc gagacaatcc ctatggataa tcagatctat actcaatcga gacgcgcgag     2040

tgctttctca acgcctcaca cgtggccacg atgctttatg aacatccagt taatttctcc     2100

aatcgacgct cccatcttgc gacagtgggc tgaaattatt catagatact ggcctaaccc     2160

ttcacagatt cgttatggtg caccgaacgt tttcggctcg gcaaatttgt tcactccacc     2220

tgaggtgctg ttattgccaa tcgatcatca accagctaat gtaacaacgc caacgctgga     2280

cttcaccaat gagttaacta attggcgcgc tcgtgtctgt gagcttatga agaatctcgt     2340

tgataaccaa agatatcaac ctggatggac acaaagtcta gtctcgtcaa tgcgcggaac     2400

gctagacaaa ttgaagttga ttaaatcgat gacaccaatg tatctgcaac agctggctcc     2460

ggtagagtta gcagtgatag ctcccatgtt gccttttcca cctttccagg tgccatacgt     2520

ccgtctcgat cgtgacagag ttccaacaat ggttggagta acacgacagt cacgagatac     2580

tattactcag ccggcgctat cgctgtcgac aaccaatact actgttggcg tgccactagc     2640

tctagacgcg agggctatca ccgttgcgct gttgtcaggg aaatatccgc cggatttggt     2700

gacaaatgta tggtacgctg atgccattta cccaatgtat gcagacacgg aggtgttctc     2760

taatcttcag agagacatga ttacctgcga ggccgtgcag acattagtga ctctggtggc     2820

gcaaatatca gagacccagt atcctgtaga taggtatctt gattggatcc catcactgag     2880

agcatcggcg gcgacggcgg cgacatttgc tgagtgggtt aatacttcaa tgaagacggc     2940

gtttgatttg tctgatatgc tgttagagcc tctcctaagc ggtgatccga ggatgactca     3000

actagcgatt cagtatcagc agtacaatgg cagaacgttt aatatcatac ctgaaatgcc     3060

aggttcagta attgctgact gcgttcaatt aacagcagaa gtctttaatc acgaatataa     3120

cctgtttggg attgcgcggg gtgatatcat cattggccgt gttcagtcga cacatttgtg     3180

gtcaccgctg gctcctccac ctgacctggt gtttgatcgt gatacccctg gtgttcacat     3240

cttcggacga gattgccgta tatcgtttgg aatgaatggc gccgcgccaa tgattagaga     3300

tgagactgga ctgatggtgc cttttgaagg aaattggatt ttcccactgg cgctttggca     3360

aatgaataca cgatatttta atcaacagtt cgacgcgtgg attaagacag gagagttgcg     3420

aatccgcatt gagatgggcg cgtatccata tatgttgcat tactatgatc cacgtcagta     3480

cgctaatgca tggaatttaa catccgcctg gcttgaagaa attacgccga cgagcatccc     3540

atccgtgcct ttcatggtgc ccatttcaag tgatcatgac atttcctctg ccccagctgt     3600

ccaatatatc atttcaactg aatataatga tcggtctctg ttctgcacta actcatcatc     3660

tccccaaacc atcgctggac cagacaaaca cattccagtt gagagatata acattctgac     3720

caaccccgac gctccaccca cgcagataca actgcctgaa gtcgttgact tgtacaacgt     3780

cgtcacacgc tatgcgtatg agactccgcc tattaccgct gttgttatgg gtgttccttg     3840

atcctcatcc tcccaacagg tgctagagca ttgcgctcaa tgctagttgg gccgattcat     3900

c                                                                     3901


<210> 61
<211> 2304
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 M1

<400> 61
gctattcgcg gtcatggctt acatcgcagt tcctgcggtg gtggattcac gttcgagtga      60

ggctattgga ctgctagaat cgtttggagt agacgctggg gctgacgcga atgacgtttc     120

atatcaagat catgactatg tgttggatca gttacagtac atgttagatg gatatgaggc     180

tggtgacgtt atcgatgcac tcgtccacaa gaattggtta catcactctg tctattgctt     240

gttgccaccc aaaagtcaac tattagagta ttggaaaagt aatccttcag cgataccgga     300

caacgttgat cgtcggcttc gtaaacgact aatgctaaag aaagatctca ggaaagatga     360

tgaatacaat cagctagcgc gtgctttcaa gatatcggat gtctacgcac ctctcatctc     420

atccacgacg tcaccgatga caatgataca gaacttgaat caaggcgaga tcgtgtacac     480

cacgacggac agggtaatag gggctagaat cttgttatat gctcctagaa agtactatgc     540

gtcaactctg tcatttacta tgactaagtg catcattccg tttggtaaag aggtgggtcg     600

tgttcctcac tctcgattta atgttggcac atttccgtca attgctaccc cgaaatgttt     660

tgtcatgagt ggggttgata ttgagtccat cccaaatgaa tttatcaagt tgttttacca     720

gcgcgtcaag agtgttcacg ctaacatact aaatgacata tctcctcaga tcgtctctga     780

catgataaac agaaagcgtc tgcgcgttca tactccatca gatcgtcgag ccgcgcagtt     840

gatgcatttg ccttaccatg ttaaacgagg agcgtctcac gtcgacgttt acaaggtgga     900

tgttgtagac atgttgttcg aggtagtgga tgtggccgat gggttgcgca acgtatctag     960

gaaactaact atgcataccg ttccggtatg tattcttgaa atgttgggta ttgagattgc    1020

ggactattgc attcgtcaag aggatggaat gctcacagat tggttcctac ttttaaccat    1080

gctatctgat ggcttgactg atagaaggac gcattgtcaa tacttgatta atccgtcaag    1140

tgtgcctcct gatgtgatac ttaacatctc aattactgga tttataaata gacatacaat    1200

cgatgtcatg cctgacatat atgacttcgt taaacccatt ggcgctgtgc tgcctaaggg    1260

atcatttaaa tcaacaatta tgagagttct tgattcaata tcaatattag gaatccaaat    1320

catgccgcgc gcgcatgtag ttgactcaga tgaggtgggc gagcaaatgg agcctacgtt    1380

tgagcaggcg gttatggaga tatacaaagg gattgctggc gttgactcgc tggatgatct    1440

catcaagtgg gtgctgaact cggatctcat tccgcatgat gacaggcttg gtcaattatt    1500

tcaagcgttt ttgcctctcg caaaggactt attagctcca atggccagaa agttttatga    1560

taactcaatg agtgagggta gattgctaac attcgctcat gccgacagtg agttgctgaa    1620

cgcaaattat tttggtcatt tattgcgact aaaaatacca tatattacag aggttaatct    1680

gatgattcgc aagaatcgtg agggtggaga gctatttcag cttgtgttat cttatctata    1740

taaaatgtat gctactagcg cgcagcctaa atggtttgga tcattattgc gattgttaat    1800

atgtccctgg ttacatatgg agaaattaat aggagaagca gacccggcat ctacgtcggc    1860

tgaaattggg tggcatatcc ctcgtgaaca gctgatgcaa gatggatggt gtggatgtga    1920

agacggattc attccctatg ttagcatacg tgcgccaaga ctggttatag aggagttgat    1980

ggagaagaac tggggccaat atcatgccca agttattgtc actgatcagc ttgtcgtagg    2040

cgaaccgcgg agggtatctg ctaaggctgt gatcaagggt aaccacttac cagttaagtt    2100

agtttcacga tttgcatgtt tcacattgac ggcgaagtat gagatgaggc tttcgtgcgg    2160

ccatagcact ggacgtggag ctgcatacag tgcgagacta gctttccgat ctgacttggc    2220

gtgatccgtg acatgcgtag tgtgacacct gctcctaggt caatgggggt agggggcggg    2280

ctaagactac gtacgcgctt catc                                           2304


<210> 62
<211> 2203
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 M2

<400> 62
gctaatctgc tgaccgttac tctgcaaaga tggggaacgc ttcctctatc gttcagacga      60

tcaacgtcac tggagatggc aatgtattta aaccatcagc tgaaacttca tctaccgctg     120

taccatcgtt aagcttatca cctggaatgc tgaatcccgg aggggtacca tggattgctg     180

ttggagatga gacatctgtg acttcaccag gcgcattacg tcgaatgacg tcaaaggaca     240

tcccggaaac ggcaataatc aacacagaca attcatcagg cgccgtgcca agcgaatcag     300

ccttggtgcc ctacatcgat gagccgctgg tagtggttac agagcatgct attaccaact     360

tcaccaaagc tgagatggca cttgaattca atcgtgagtt ccttgacaag atgcgtgtgc     420

tgtcagtgtc accaaaatat tcggatcttc tgacctatgt tgactgctac gtcggtgtgt     480

ctgctcgtca ggctttaaac aattttcaga aacaagtgcc tgtgattaca cctactaggc     540

agacgatgta tgtcgactcg atacaagcgg ccttgaaagc tttagaaaag tgggagattg     600

atctgagagt ggctcaaacg ttgctgccta cgaacgttcc gattggagaa gtctcttgtc     660

caatgcagtc ggtagtgaaa ctgctggatg atcagctgcc agatgacagc ctgatacgga     720

ggtatcccaa ggaagccgcc gtcgctttgg ctaaacgaaa cgggggaata caatggatgg     780

acgtatcaga aggcaccgtg atgaacgagg ctgtcaacgc tgttgcagct agtgcactgg     840

caccttcagc atcagcccca cccttagaag agaagtcaaa gttaaccgaa caagcgatgg     900

atctcgtgac cgcggctgag cctgagataa ttgcctcact cgtgccagtt cccgcacccg     960

tgtttgccat accacctaaa ccagcagatt ataatgtgcg tactctgagg atcgacgagg    1020

ccacttggct gcgaatgatt ccaaaatcaa tgaacacacc ttttcaaatc caggtgactg    1080

ataacacagg aactaattgg catctcaatt tgaggggggg gactcgtgta gtgaatctgg    1140

accaaatcgc tccgatgcgg tttgtattag atctaggggg aaagagttat aaagagacga    1200

gctgggatcc aaacggcaag aaggtcggat tcatcgtttt tcaatcgaag ataccattcg    1260

aactttggac tgctgcttca cagatcggtc aagccacggt ggttaactat gtccaactat    1320

acgctgaaga cagctcattt accgcgcagt ctatcattgc tactacctct ttggcttata    1380

actatgagcc tgagcagttg aataagactg accctgagat gaattattat cttttggcga    1440

cctttataga ctcagccgct ataacgccaa cgaatatgac acagcctgat gtttgggatg    1500

ccttgctgac gatgtcccca ctatcagctg gcgaggtgac agtgaagggt gcggtagtga    1560

gtgaagtagt ccctgcagac ttgataggta gctacactcc agaatcccta aacgcctcac    1620

ttccgaatga tgctgctaga tgcatgatcg atagagcttc gaagatagcc gaagcaatca    1680

agattgatga tgatgctgga ccagatgaat attccccaaa ctctgtacca attcaaggtc    1740

agcttgctat ctcgcaactc gaaactggat atggtgtgcg aatattcaac cctaaaggga    1800

tcctttctaa aattgcatct agggcaatgc aggctttcat tggtgacccg agcacaatca    1860

tcacgcaggc ggcgccagtg ttatcagaca agaataattg gattgcattg gcacagggag    1920

tgaaaactag tctgcgtact aaaagtctat cagcgggagt gaagactgca gtgagtaagc    1980

tgagctcatc tgagtctatc cagaattgga ctcaaggatt cttggataaa gtgtcagcgc    2040

attttccagc accaaagccc gattgtccga ctagcggaga tagtggtgaa tcgtctaatc    2100

gccgagtgaa gcgcgactca tacgcaggag tggtcaaacg tgggtacaca cgttaggccg    2160

ctcgccctgg tgacgcgggg ttaagggatg caggcaaatc atc                      2203



<210> 63
<211> 2241
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 M3

<400> 63
gctaaagtga ccgtggtcat ggcttcattc aagggattct ccgccaacac tgttccagtt      60

tctaaggcca agcgtgacat atcatctctt gccgctactc ctggacttcg ttcacaatcc     120

ttcactccgt ctgtggatat gtctcaatcg cgtgaattcc tcacaaaggc aattgagcaa     180

gggtccatgt ctatacctta tcagcatgtg aatgtaccga aagttgatcg taaagttgtt     240

agcctggtag tgcgaccttt ctcttcaggt gctttctcta tctctggagt gatttcgcca     300

gcccatgcct atctactaga gtgtctaccc cagcttgagc aggcgatggc ttttgttgct     360

tcacctgagt ctttccaggc ttccgacgtc gcgaagcgct ttgccataaa gccaggtatg     420

agcctccagg atgccatcac tgcctttatt aactttgtgt ccgcgatgct gaaaatgacg     480

gtgactcgtc aaaactttga cgttattgtg gctgagatcg agaggcttgc ttcaaccagc     540

gtgtccgtca ggactgaaga agcgaaggtt gctgatgagg agctaatgct attcgggtta     600

gatcatagag ggccacagca gctggatgtt tctgacgcta aagggataat gaaggctgct     660

gatattcaga caactcatga tgtccatttg gcaccaggcg ttggtaatat tgatcctgaa     720

atctataacg aggggcggtt catgttcatg cagcacaagc cacttgcggc ggatcaatcg     780

tatttcacct tggagactgc ggattatttc aagatttatc caacatacga tgaacatgat     840

ggcaggatgg ctgaccaaaa gcagtcggga ttgatactgt gtactaagga cgaggtattg     900

gctgagcaaa ctatatttaa actggacgcc cctgatgaca agactgttca tctgttggat     960

cgcgatgacg accacgttgt tgccagattt actaaggtat ttatagagga cgtggctccc    1020

gggcatcatg ctgctcaaag atcgggacaa cgctctgtgc ttgatgacct atatgcgaat    1080

acgcaagtga tttccattac ttctgctgct ttaaagtggg tggtcaagca cggcgtatct    1140

gatggaatcg tgaacaggaa gaatgtcaaa gtgtgtgttg gttttgaccc cctgtacacc    1200

ttgtctacac ataacggggt gtccttatgt gccctgctga tggacgaaaa actctctgtg    1260

ctgaacagtg cgtgtcgtat gacgttacgc tcactcatga agaccggacg cgacgttgat    1320

gcacacagag cttttcagcg agtcctctct caaggataca catcgctaat gtgctactat    1380

catccttcac ggaagttggc atatggtgag gtgctctttc tagaacgatc caatgacgtg    1440

acagatggga tcaagcttca gttggacgca tctagacagt gtcatgaatg tcctgtgttg    1500

cagcagaaag tggttgagtt agagaaacag attattatgc agaagtcaat ccagtcagac    1560

cctaccccag tggcgctgca accattgttg tctcagttgc gtgagttgtc tagtgaagtt    1620

actaggctac agatggagtt gagtcgagct cagtccctga atgctcagtt ggaggcggat    1680

gtcaagtcag ctcaatcatg tagcttggat atgtatctga gacaccacac ttgcattaat    1740

ggtcatgcta aagaagatga attgcttgac gctgtgcgtg tcgcgccgga tgtgaggaga    1800

gaaatcatgg aaaagaggag tgaagtgaga caaggttggt gcgaacgtat ttctaaggaa    1860

gcagctgcca aatgtcaaac tgttattgat gacctgactt tgatgaatgg aaagcaagca    1920

caagagataa cagaattacg tgattcggct gaaaaatatg agaaacagat tgcagagctg    1980

gtgagtacca tcacccaaaa ccagataacg tatcagcaag agctacaagc cttggtagcg    2040

aaaaatgtgg aattggacgc gttgaatcag cgtcaggcta agtctttgcg tattactccc    2100

tctcttctat cagccactcc taccgattca gttgatggtg ttgctgactt aattgatttc    2160

tctgttccaa ctgatgagtt gtaaataatc cgtgatgcag tgttgcccta atcccttaag    2220

ccttcccgac ccccattcat c                                              2241


<210> 64
<211> 1416
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 S1

<400> 64
gctattggtc ggatggatcc tcgcctacgt gaagaagtag tacggctgat aatcgcatta      60

acgagtgata atggagtatc actgtcaaaa gggcttgaat caagggtctc ggcgctcgag     120

aagacgtctc aaatacactc tgatactatc ctccggatca cccagggact cgatgatgca     180

aacaaacgaa tcatcgctct tgagcaaagt cgggatgact tggttgcatc agtcagtgat     240

gctcaacttg caatctccag attggaaagc tctatcggag ccctccaaac agttgtcaat     300

ggacttgatt cgagtgttac ccagttgggt gctcgagtgg gacaacttga gacaggactt     360

gcagagctac gcgttgatca cgacaatctc gttgcgagag tggatactgc agaacgtaac     420

attggatcat tgaccactga gctatcaact ctgacgttac gagtaacatc catacaagcg     480

gatttcgaat ctaggatatc cacattagag cgcacggcgg tcactagcgc gggagctccc     540

ctctcaatcc gtaataaccg tatgaccatg ggattaaatg atggactcac gttgtcaggg     600

aataatctcg ccatccgatt gccaggaaat acgggtctga atattcaaaa tggtggactt     660

cagtttcgat ttaatactga tcaattccag atagttaata ataacttgac tctcaagacg     720

actgtgtttg attctatcaa ctcaaggata ggcgcaactg agcaaagtta cgtggcgtcg     780

gcagtgactc ccttgagatt aaacagtagc acgaaggtgc tggatatgct aatagacagt     840

tcaacacttg aaattaattc tagtggacag ctaactgtta gatcgacatc cccgaatttg     900

aggtatccga tagctgatgt tagcggcggt atcggaatga gtccaaatta taggtttagg     960

cagagcatgt ggataggaat tgtctcctat tctggtagtg ggctgaattg gagggtacag    1020

gtgaactccg acatttttat tgtagatgat tacatacata tatgtcttcc agcttttgac    1080

ggtttctcta tagctgacgg tggagatcta tcgttgaact ttgttaccgg attgttacca    1140

ccgttactta caggagacac tgagcccgct tttcataatg acgtggtcac atatggagca    1200

cagactgtag ctatagggtt gtcgtcgggt ggtgcgcctc agtatatgag taagaatctg    1260

tgggtggagc agtggcagga tggagtactt cggttacgtg ttgagggggg tggctcaatt    1320

acgcactcaa acagtaagtg gcctgccatg accgtttcgt acccgcgtag tttcacgtga    1380

ggatcagacc accccgcggc actggggcat ttcatc                              1416


<210> 65
<211> 1331
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 S2

<400> 65
gctattcgct ggtcagttat ggctcgcgct gcgttcctat tcaagactgt tgggtttggt      60

ggtctgcaaa atgtgccaat taacgacgaa ctatcttcac atctactccg agctggtaat     120

tcaccatggc agttaacaca gtttttagac tggataagcc ttgggagggg tttagctaca     180

tcggctctcg ttccgacggc tgggtcaaga tactatcaaa tgagttgcct tctaagtggc     240

actctccaga ttccgttccg tcctaaccac cgatggggag acattaggtt cttacgctta     300

gtgtggtcag ctcctactct cgatggatta gtcgtagctc caccacaagt tttggctcag     360

cccgctttgc aagcacaggc agatcgagtg tacgactgcg atgattatcc atttctagcg     420

cgtgatccaa gattcaaaca tcgggtgtat cagcaattga gtgctgtaac tctacttaac     480

ttgacaggtt ttggcccgat ttcctacgtt cgagtggatg aagatatgtg gagtggagat     540

gtgaaccagc ttctcatgaa ctatttcggg cacacgtttg cagagattgc atacacattg     600

tgtcaagcct cggctaatag gccttgggaa tatgacggta catatgctag gatgactcag     660

attgtgttat ccttgttctg gctatcgtat gtcggtgtaa ttcatcagca gaatacgtat     720

cggacattct attttcagtg taatcggcga ggtgacgccg ctgaggtgtg gattctttct     780

tgttcgttga accattccgc acaaattaga ccgggtaatc gtagcttatt cgttatgcca     840

actagcccag attggaacat ggacgtcaat ttgatcctga gttcaacgtt gacggggtgt     900

ttgtgttcgg gttcacagct gccactgatt gacaataatt cagtacctgc agtgtcgcgt     960

aacatccatg gctggactgg tagagctggt aaccaattgc atgggttcca ggtgagacga    1020

atggtgactg aattttgtga caggttgaga cgcgatggtg tcatgaccca agctcagcag    1080

aatcaagttg aagcgttggc agatcagact caacagttta agagggacaa gctcgaaacg    1140

tgggcgagag aagacgatca atataatcag gctcatccca actccacaat gttccgtacg    1200

aaaccattta cgaatgcgca atggggacga ggtaatacgg gggcgactag tgccgcgatt    1260

gcagccctta tctgatcgtc ttggagtgag ggggtccccc cacacacctc acgactgacc    1320

acacattcat c                                                         1331


<210> 66
<211> 1198
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 S3

<400> 66
gctaaagtca cgcctgtcgt cgtcactatg gcttcctcac tcagagctgc gatctccaag      60

atcaagaggg atgacgtcgg tcagcaagtt tgtcctaatt atgtcatgct gcggtcctct     120

gtcacaacaa aggtggtacg aaatgtggtt gagtatcaaa ttcgtacggg cggattcttt     180

tcgtgcttag ctatgctaag gccactccag tacgctaagc gtgagcgttt gcttggtcag     240

aggaatctgg aacgtatatc gactagggat atccttcaga ctcgtgattt acactcacta     300

tgtatgccaa ctcctgatgc gccaatgtct aatcatcaag catccaccat gagagagctg     360

atttgcagtt acttcaaggt cgatcatgcg gatgggttga aatatatacc catggatgag     420

agatactctc cgtcatcact tgccagattg tttaccatgg gcatggctgg gctgcacatt     480

accactgagc catcttataa gcgtgttccg attatgcact tagctgcgga cttggactgt     540

atgacgctgg ctctacctta catgattacg cttgatggtg atactgtggt tcctgtcgct     600

ccaacactgt cagcggaaca gcttctggac gacggactca aaggattagc atgcatggat     660

atctcctatg gatgtgaggt ggacgcgaat agccggccgg ctggtgatca gagtatggac     720

tcttcacgct gcatcaacga gttgtattgc gaggagacag cagaagccat ctgtgtgctt     780

aagacatgcc ttgtgttaaa ttgcatgcag tttaaacttg agatggatga cctagcacat     840

aacgctgctg agctggacaa gatacagatg atgataccct tcagtgagcg tgtttttagg     900

atggcctcgt cctttgcgac tattgatgcc cagtgtttta ggttttgcgt gatgatgaag     960

gataaaaatc tgaaaataga tatgcgtgaa acgacgagac tgtggactcg ttcagcatca    1020

gatgattctg tggccacgtc atctttaagt atttccctgg accggggtcg atgggtggcg    1080

gctgacgcca gtgatgctag actgctggtt tttccgattc gcgtgtaatg ggtgagtgag    1140

ctgatgtggt cgccaagaca tgtgccggtg tcttggtggt gggtgacgcc taatcatc      1198


<210> 67
<211> 1196
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reovirus type 3 S4

<400> 67
gctatttttg cctcttccca gacgttgtcg caatggaggt gtgcttgccc aacggtcatc      60

aggtcgtgga cttgattaac aacgcttttg aaggtcgtgt atcaatctac agcgcgcaag     120

agggatggga caaaacaatc tcagcacagc cagatatgat ggtatgtggt ggcgccgtcg     180

tttgcatgca ttgtctaggt gttgttggat ctctacaacg caagctgaag catttgcctc     240

accatagatg taatcaacag atccgtcatc aggattacgt cgatgtacag ttcgcagacc     300

gtgttactgc tcactggaag cggggtatgc tgtccttcgt tgcgcagatg cacgagatga     360

tgaatgacgt gtcgccagat gacctggatc gtgtgcgtac tgagggaggt tcactagtgg     420

agctgaactg gcttcaggtt gacccaaatt caatgtttag atcaatacac tcaagttgga     480

cagatccttt gcaggtggtg gacgaccttg acactaagct ggatcagtac tggacagcct     540

taaacctgat gatcgactca tccgacttga tacccaactt tatgatgaga gacccatcac     600

acgcgttcaa tggtgtgaaa ctggagggag atgctcgtca aacccaattc tccaggactt     660

ttgattcgag atcgagtttg gaatggggtg tgatggttta tgattactct gagctggagc     720

atgatccatc gaatggccgt gcttacagaa aggaattggt gacgccagct cgagatttcg     780

gtcactttgg attatcccat tattctaggg cgactacccc aatccttgga aagatgccgg     840

ccgtattctc aggaatgttg actgggaact gtaaaatgta tccattcatt aaaggaacgg     900

ctaagctgaa gacagtgcgc aagctagtgg aggcagtcaa tcatgcttgg ggtgtcgaga     960

agattagata tgctcttggg ccaggtggca tgacgggatg gtacaatagg actatgcaac    1020

aggcccccat tgtgctaact cctgctgctc tcacaatgtt cccagatacc atcaagtttg    1080

gggatttgaa ttatccagtg atgattggcg atccgatgat tcttggctaa acacccccat    1140

cttcacagcg ccgggcttga ccaacctggt gtgacgtggg acaggcttca ttcatc        1196


