﻿                         序列表

<110>  北京市神经外科研究所

<120>  抗CD133的单链抗体及其在制备治疗肿瘤的药物中的用途

<130>  17160BJNI-LGZ

<160>  10

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  244
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Asp Ile Asp Pro Gly Thr Gly Asp Thr Ala Tyr Asn Leu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Leu Gly Ala Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 
Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 
Leu Ala Asn Ser Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys 
                165                 170                 175     
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe 
            180                 185                 190         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 
Cys Leu Gln Gly Thr His Gln Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 
Leu Glu Ile Lys 
                

<210>  2
<211>  732
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  2
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc        60
tcctgcaagg cttctggtta cacctttacc gactttgaaa tgcactgggt gcgacaggcc       120
cctggacaag ggcttgagtg gatgggagat attgatcctg gaactggtga tactgcctac       180
aatctgaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac       240
atggagctga ggagcctgag gtctgacgac acggccgtgt attactgtgc gttgggggcc       300
tttgtttact ggggccaggg aaccctggtc accgtctcct caggcagtac tagcggtggt       360
ggctccgggg gcggttccgg tgggggcggc agcagcgatg ttgtgatgac tcagtctcca       420
ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtcagagt       480
cttgcaaaca gttatgggaa cacctatttg tcttggtacc tgcagaagcc agggcagtct       540
ccacagctcc tgatctatgg gatttccaac agattttctg gggtccctga caggttcagt       600
ggcagtggat caggcacaga ttttacactg aaaatcagca gagtggaggc tgaggacgtt       660
ggggtttatt actgcttaca aggtacacat cagccgtaca cgtttggcca ggggaccaag       720
ctggagatca aa                                                           732

<210>  3
<211>  466
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Asp Ile Asp Pro Gly Thr Gly Asp Thr Ala Tyr Asn Leu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Leu Gly Ala Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 
Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 
Leu Ala Asn Ser Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys 
                165                 170                 175     
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe 
            180                 185                 190         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 
Cys Leu Gln Gly Thr His Gln Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 
Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     
Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         
Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             
Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 
Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 
Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     
Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         
Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        355                 360                 365             
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                405                 410                 415     
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            420                 425                 430         
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        435                 440                 445             
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    450                 455                 460                 
Pro Arg 
465     

<210>  4
<211>  561
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Asp Ile Asp Pro Gly Thr Gly Asp Thr Ala Tyr Asn Leu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Leu Gly Ala Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 
Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 
Leu Ala Asn Ser Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys 
                165                 170                 175     
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe 
            180                 185                 190         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 
Cys Leu Gln Gly Thr His Gln Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 
Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     
Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         
Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             
Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 
Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 
Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     
Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         
Arg Ser Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp 
        355                 360                 365             
His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu 
    370                 375                 380                 
Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg 
385                 390                 395                 400 
Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
                405                 410                 415     
Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Leu Gly 
            420                 425                 430         
Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
        435                 440                 445             
Gln Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    450                 455                 460                 
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
465                 470                 475                 480 
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                485                 490                 495     
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            500                 505                 510         
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        515                 520                 525             
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    530                 535                 540                 
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
545                 550                 555                 560 
Arg 
    

<210>  5
<211>  737
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Asp Ile Asp Pro Gly Thr Gly Asp Thr Ala Tyr Asn Leu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Leu Gly Ala Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 
Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 
Leu Ala Asn Ser Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys 
                165                 170                 175     
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe 
            180                 185                 190         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 
Cys Leu Gln Gly Thr His Gln Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 
Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     
Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         
Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             
Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 
Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 
Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     
Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         
Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        355                 360                 365             
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                405                 410                 415     
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            420                 425                 430         
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        435                 440                 445             
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    450                 455                 460                 
Pro Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
465                 470                 475                 480 
Asn Pro Gly Pro Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu 
                485                 490                 495     
Leu Cys Phe Ser Thr Thr Ala Leu Ser Gln Val Gln Leu Gln Gln Ser 
            500                 505                 510         
Gly Pro Gly Leu Val Lys Pro Ser His Thr Leu Ser Leu Thr Cys Thr 
        515                 520                 525             
Val Ser Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Thr 
    530                 535                 540                 
Arg Gln His Pro Gly Met Gly Leu Glu Trp Ile Gly Tyr Ile Ser Tyr 
545                 550                 555                 560 
Ser Gly Ser Ile Tyr Tyr Thr Pro Ser Leu Lys Ser Arg Leu Thr Ile 
                565                 570                 575     
Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
            580                 585                 590         
Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Asp Ser Trp 
        595                 600                 605             
Gly Ser Asn Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    610                 615                 620                 
Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
625                 630                 635                 640 
Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
                645                 650                 655     
Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            660                 665                 670         
Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile 
        675                 680                 685             
Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    690                 695                 700                 
Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
705                 710                 715                 720 
Arg Ser Asn Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
                725                 730                 735     
Lys 
    

<210>  6
<211>  832
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Asp Ile Asp Pro Gly Thr Gly Asp Thr Ala Tyr Asn Leu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Leu Gly Ala Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 
Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 
Leu Ala Asn Ser Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys 
                165                 170                 175     
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe 
            180                 185                 190         
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 
Cys Leu Gln Gly Thr His Gln Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 
Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     
Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         
Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             
Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 
Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 
Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     
Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         
Arg Ser Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp 
        355                 360                 365             
His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu 
    370                 375                 380                 
Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg 
385                 390                 395                 400 
Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp 
                405                 410                 415     
Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Leu Gly 
            420                 425                 430         
Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
        435                 440                 445             
Gln Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    450                 455                 460                 
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
465                 470                 475                 480 
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                485                 490                 495     
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            500                 505                 510         
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        515                 520                 525             
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    530                 535                 540                 
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
545                 550                 555                 560 
Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
                565                 570                 575     
Pro Gly Pro Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu 
            580                 585                 590         
Cys Phe Ser Thr Thr Ala Leu Ser Gln Val Gln Leu Gln Gln Ser Gly 
        595                 600                 605             
Pro Gly Leu Val Lys Pro Ser His Thr Leu Ser Leu Thr Cys Thr Val 
    610                 615                 620                 
Ser Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Thr Arg 
625                 630                 635                 640 
Gln His Pro Gly Met Gly Leu Glu Trp Ile Gly Tyr Ile Ser Tyr Ser 
                645                 650                 655     
Gly Ser Ile Tyr Tyr Thr Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser 
            660                 665                 670         
Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 
        675                 680                 685             
Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Asp Ser Trp Gly 
    690                 695                 700                 
Ser Asn Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
705                 710                 715                 720 
Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
                725                 730                 735     
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
            740                 745                 750         
Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        755                 760                 765             
Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
    770                 775                 780                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
785                 790                 795                 800 
Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg 
                805                 810                 815     
Ser Asn Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            820                 825                 830         

<210>  7
<211>  1398
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  7
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc        60
tcctgcaagg cttctggtta cacctttacc gactttgaaa tgcactgggt gcgacaggcc       120
cctggacaag ggcttgagtg gatgggagat attgatcctg gaactggtga tactgcctac       180
aatctgaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac       240
atggagctga ggagcctgag gtctgacgac acggccgtgt attactgtgc gttgggggcc       300
tttgtttact ggggccaggg aaccctggtc accgtctcct caggcagtac tagcggtggt       360
ggctccgggg gcggttccgg tgggggcggc agcagcgatg ttgtgatgac tcagtctcca       420
ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtcagagt       480
cttgcaaaca gttatgggaa cacctatttg tcttggtacc tgcagaagcc agggcagtct       540
ccacagctcc tgatctatgg gatttccaac agattttctg gggtccctga caggttcagt       600
ggcagtggat caggcacaga ttttacactg aaaatcagca gagtggaggc tgaggacgtt       660
ggggtttatt actgcttaca aggtacacat cagccgtaca cgtttggcca ggggaccaag       720
ctggagatca aaaccactac cccagcaccg aggccaccca ccccggctcc taccatcgcc       780
tcccagcctc tgtccctgcg tccggaggca tgtagacccg cagctggtgg ggccgtgcat       840
acccggggtc ttgacttcgc ctgcgatatc tacatttggg cccctctggc tggtacttgc       900
ggggtcctgc tgctttcact cgtgatcact ctttactgta ggagtaagag gagcaggctc       960
ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac      1020
cagccctatg ccccaccacg cgacttcgca gcctatcgct cccgcgtgaa attcagccgc      1080
agcgcagatg ctccagccta caagcagggg cagaaccagc tctacaacga actcaatctt      1140
ggtcggagag aggagtacga cgtgctggac aagcggagag gacgggaccc agaaatgggc      1200
gggaagccgc gcagaaagaa tccccaagag ggcctgtaca acgagctcca aaaggataag      1260
atggcagaag cctatagcga gattggtatg aaaggggaac gcagaagagg caaaggccac      1320
gacggactgt accagggact cagcaccgcc accaaggaca cctatgacgc tcttcacatg      1380
caggccctgc cgcctcgg                                                    1398

<210>  8
<211>  1683
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  8
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc        60
tcctgcaagg cttctggtta cacctttacc gactttgaaa tgcactgggt gcgacaggcc       120
cctggacaag ggcttgagtg gatgggagat attgatcctg gaactggtga tactgcctac       180
aatctgaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac       240
atggagctga ggagcctgag gtctgacgac acggccgtgt attactgtgc gttgggggcc       300
tttgtttact ggggccaggg aaccctggtc accgtctcct caggcagtac tagcggtggt       360
ggctccgggg gcggttccgg tgggggcggc agcagcgatg ttgtgatgac tcagtctcca       420
ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtcagagt       480
cttgcaaaca gttatgggaa cacctatttg tcttggtacc tgcagaagcc agggcagtct       540
ccacagctcc tgatctatgg gatttccaac agattttctg gggtccctga caggttcagt       600
ggcagtggat caggcacaga ttttacactg aaaatcagca gagtggaggc tgaggacgtt       660
ggggtttatt actgcttaca aggtacacat cagccgtaca cgtttggcca ggggaccaag       720
ctggagatca aaaccactac cccagcaccg aggccaccca ccccggctcc taccatcgcc       780
tcccagcctc tgtccctgcg tccggaggca tgtagacccg cagctggtgg ggccgtgcat       840
acccggggtc ttgacttcgc ctgcgatatc tacatttggg cccctctggc tggtacttgc       900
ggggtcctgc tgctttcact cgtgatcact ctttactgta ggagtaagag gagcaggctc       960
ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac      1020
cagccctatg ccccaccacg cgacttcgca gcctatcgct ccaaaaaaag gattaagcct      1080
atcgtatggc ccagtctccc cgatcacaag aagactctgg aacacctttg taagaaacca      1140
agaaaaaatt taaatgtgag tttcaatcct gaaagtttcc tggactgcca gattcatagg      1200
gtggatgaca ttcaagctag agatgaagtg gaaggttttc tgcaagatac gtttcctcag      1260
caactagaag aatctgagaa gcagaggctt ctgggatcaa atcaagaaga agcatatgtc      1320
accatgtcca gcttctacca aaaccagcgc gtgaaattca gccgcagcgc agatgctcca      1380
gcctacaagc aggggcagaa ccagctctac aacgaactca atcttggtcg gagagaggag      1440
tacgacgtgc tggacaagcg gagaggacgg gacccagaaa tgggcgggaa gccgcgcaga      1500
aagaatcccc aagagggcct gtacaacgag ctccaaaagg ataagatggc agaagcctat      1560
agcgagattg gtatgaaagg ggaacgcaga agaggcaaag gccacgacgg actgtaccag      1620
ggactcagca ccgccaccaa ggacacctat gacgctcttc acatgcaggc cctgccgcct      1680
cgg                                                                    1683

<210>  9
<211>  2211
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc        60
tcctgcaagg cttctggtta cacctttacc gactttgaaa tgcactgggt gcgacaggcc       120
cctggacaag ggcttgagtg gatgggagat attgatcctg gaactggtga tactgcctac       180
aatctgaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac       240
atggagctga ggagcctgag gtctgacgac acggccgtgt attactgtgc gttgggggcc       300
tttgtttact ggggccaggg aaccctggtc accgtctcct caggcagtac tagcggtggt       360
ggctccgggg gcggttccgg tgggggcggc agcagcgatg ttgtgatgac tcagtctcca       420
ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtcagagt       480
cttgcaaaca gttatgggaa cacctatttg tcttggtacc tgcagaagcc agggcagtct       540
ccacagctcc tgatctatgg gatttccaac agattttctg gggtccctga caggttcagt       600
ggcagtggat caggcacaga ttttacactg aaaatcagca gagtggaggc tgaggacgtt       660
ggggtttatt actgcttaca aggtacacat cagccgtaca cgtttggcca ggggaccaag       720
ctggagatca aaaccactac cccagcaccg aggccaccca ccccggctcc taccatcgcc       780
tcccagcctc tgtccctgcg tccggaggca tgtagacccg cagctggtgg ggccgtgcat       840
acccggggtc ttgacttcgc ctgcgatatc tacatttggg cccctctggc tggtacttgc       900
ggggtcctgc tgctttcact cgtgatcact ctttactgta ggagtaagag gagcaggctc       960
ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac      1020
cagccctatg ccccaccacg cgacttcgca gcctatcgct cccgcgtgaa attcagccgc      1080
agcgcagatg ctccagccta caagcagggg cagaaccagc tctacaacga actcaatctt      1140
ggtcggagag aggagtacga cgtgctggac aagcggagag gacgggaccc agaaatgggc      1200
gggaagccgc gcagaaagaa tccccaagag ggcctgtaca acgagctcca aaaggataag      1260
atggcagaag cctatagcga gattggtatg aaaggggaac gcagaagagg caaaggccac      1320
gacggactgt accagggact cagcaccgcc accaaggaca cctatgacgc tcttcacatg      1380
caggccctgc cgcctcggga gggaaggggt tctctcctga cctgcggcga tgtggaggag      1440
aaccccggac ccatgaccaa caagtgtctc ctccaaattg ctctcctgtt gtgcttctcc      1500
actacagctc tttcccaggt gcagctacag cagtcgggcc caggactggt gaagccttca      1560
cacaccctgt ccctcacctg cactgtctct ggtggctcca tcagcagtgg tggttactac      1620
tggagttgga cccgtcagca cccagggatg ggcctggagt ggattggata catctcttac      1680
agtgggagta tctattacac tccgtccctc aagagtcgac ttaccatatc agtggacacg      1740
tctaagaacc agttctccct gaagctgagc tctgtgactg ccgcggacac ggccgtatat      1800
tactgtgcga gtttggattc ctggggatct aaccgtgact actggggcca gggaaccctg      1860
gtcaccgtct cgagtggagg tggtggatcc gaaattgtgt tgacgcagtc tccagccacc      1920
ctgtctttgt ctccagggga aagagccacc ctctcctgca gggccagtca gagtgttagc      1980
agctacttag cctggtacca acagaaacct ggccaggctc ccaggctcct catctatgat      2040
gcatccaaca gggccactgg catcccagcc aggttcagtg gcagtgggtc tgggacagac      2100
ttcactctca ccatcagcag cctagagcct gaagattttg cagtttatta ctgtcagcag      2160
cgtagcaact ggccgctcac tttcggcgga gggaccaagg tggagattaa g               2211

<210>  10
<211>  2534
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc        60
tcctgcaagg cttctggtta cacctttacc gactttgaaa tgcactgggt gcgacaggcc       120
cctggacaag ggcttgagtg gatgggagat attgatcctg gaactggtga tactgcctac       180
aatctgaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac       240
atggagctga ggagcctgag gtctgacgac acggccgtgt attactgtgc gttgggggcc       300
tttgtttact ggggccaggg aaccctggtc accgtctcct caggcagtac tagcggtggt       360
ggctccgggg gcggttccgg tgggggcggc agcagcgatg ttgtgatgac tcagtctcca       420
ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtcagagt       480
cttgcaaaca gttatgggaa cacctatttg tcttggtacc tgcagaagcc agggcagtct       540
ccacagctcc tgatctatgg gatttccaac agattttctg gggtccctga caggttcagt       600
ggcagtggat caggcacaga ttttacactg aaaatcagca gagtggaggc tgaggacgtt       660
ggggtttatt actgcttaca aggtacacat cagccgtaca cgtttggcca ggggaccaag       720
ctggagatca aaaccactac cccagcaccg aggccaccca ccccggctcc taccatcgcc       780
tcccagcctc tgtccctgcg tccggaggca tgtagacccg cagctggtgg ggccgtgcat       840
acccggggtc ttgacttcgc ctgcgatatc tacatttggg cccctctggc tggtacttgc       900
ggggtcctgc tgctttcact cgtgatcact ctttactgta ggagtaagag gagcaggctc       960
ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac      1020
cagccctatg ccccaccacg cgacttcgca gcctatcgct ccaaaaaaag gattaagcct      1080
atcgtatggc ccagtctccc cgatcacaag aagactctgg aacacctttg taagaaacca      1140
agaaaaaatt taaatgtgag tttcaatcct gaaagtttcc tggactgcca gattcatagg      1200
gtggatgaca ttcaagctag agatgaagtg gaaggttttc tgcaagatac gtttcctcag      1260
caactagaag aatctgagaa gcagaggctt ctgggatcaa atcaagaaga agcatatgtc      1320
accatgtcca gcttctacca aaaccagcgc gtgaaattca gccgcagcgc agatgctcca      1380
gcctacaagc aggggcagaa ccagctctac aacgaactca atcttggtcg gagagaggag      1440
tacgacgtgc tggacaagcg gagaggacgg gacccagaaa tgggcgggaa gccgcgcaga      1500
aagaatcccc aagagggcct gtacaacgag ctccaaaagg ataagatggc agaagcctat      1560
agcgagattg gtatgaaagg ggaacgcaga agaggcaaag gccacgacgg actgtaccag      1620
ggactcagca ccgccaccaa ggacacctat gacgctcttc acatgcaggc cctgccgcct      1680
cgggagggaa ggggttctct cctgacctgc ggcgatgtgg aggagaaccc cggacccatg      1740
accaacaagt gtctcctcca aattgctctc ctgttgtgct tctccactac agctctttcc      1800
caggtgcagc tacagcagtc gggcccagga ctggtgaagc cttcacacac cctgtccctc      1860
acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ttggacccgt      1920
cagcacccag ggatgggcct ggagtggatt ggatacatct cttacagtgg gagtatctat      1980
tacactccgt ccctcaagag tcgacttacc atatcagtgg acacgtctaa gaaccagttc      2040
tccctgaagc tgagctctgt gactgccgcg gacacggccg tatattactg tgcgagtttg      2100
gattcctggg gatctaaccg tgactactgg ggccagggaa ccctggtcac cgtctcgagt      2160
ggaggtggtg gatccgaaat tgtgttgacg cagtctccag ccaccctgtc tttgtctcca      2220
ggggaaagag ccaccctctc ctgcagggcc agtcagagtg ttagcagcta cttagcctgg      2280
taccaacaga aacctggcca ggctcccagg ctcctcatct atgatgcatc caacagggcc      2340
actggcatcc cagccaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc      2400
agcagcctag agcctgaaga ttttgcagtt tattactgtc agcagcgtag caactggccg      2460
ctcactttcg gcggagggac caaggtggag attaagcgct cactttcggc ggagggacca      2520
aggtggagat taag                                                        2534

