﻿                         序列表

<110>  中国科学院微生物研究所

<120>  一种抗新型冠状病毒的双特异性抗体及其应用

<130>  DSP1P211341J

<150>  202010763140.X
<151>  2020-08-01

<160>  35

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1743
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  1
caggttcagt tagttcagag tggagcagaa gtgaagaagc ccggtgcctc tgtgaaagtg        60
tcatgcaaag catcaggata cacatttaca ggatactaca tgcactgggt taggcaggcg       120
cccggtcaag gcctggagtg gatgggcaga atcaacccta actctggcgg gacgaattat       180
gcacagaagt tccagggaag agtgacaatg acaagagata catcaatctc aacagcatac       240
atggaacttt caagacttag atcagatgac actgctgtct actactgcgc acgagtcccg       300
tactgctcat caacatcatg ccacagagat tggtactttg atctttgggg gagaggtaca       360
cttgtgacag tctcatcggg tggaggcgga tcagggggtg gtggctccga agtccagctc       420
gtcgagagtg gtggaggact ggttcaacct ggaggatcac ttagactttc atgcgcagca       480
tcaggattta tcgtgtcatc aaactacatg tcatgggtac gccaggctcc cgggaagggt       540
ctggagtggg tctcggtgat ctactcagga ggatcaacat actacgcaga ttcagtgaaa       600
ggaagattta caatctcaag acacaactca aagaatactc tttaccttca aatgaactca       660
cttagagcag aagacactgc ggtttactac tgcgcaagag aagcgtacgg aatggatgtg       720
tggggccagg gtacaacagt tactgtttcg tctgcgtcca ctaaaggccc ttccgtcttc       780
ccgctggcac cttcatcaaa gtctacttct ggtggaacgg cggctcttgg atgtctggtt       840
aaggactatt tcccggagcc tgtaactgta tcgtggaact caggagcact tacatcagga       900
gtgcacacat ttcctgcagt gcttcaatca tcaggacttt actcactttc atcagtggtg       960
acagtgcctt catcatcact tggaacacaa acatacatct gcaacgtgaa ccacaaacct      1020
tcaaacacaa aggttgacaa gaaggtcgag cctaaatcat gcgataagac tcatacatgc      1080
cctccttgcc ctgcacctga acttcttgga ggcccgtcgg tgtttttatt cccgccaaaa      1140
ccgaaggata cacttatgat ctcaagaaca cctgaagtga catgcgtggt ggtggatgtg      1200
tcacacgaag atcctgaagt gaaatttaac tggtacgtgg atggagtgga agtgcacaac      1260
gcaaagacta agcctagaga agaacaatac aactcaacat acagagtggt gtcagtgctt      1320
acagtgcttc accaagattg gcttaacgga aaggagtata aatgcaaagt gtcaaacaaa      1380
gcacttcctg cacctatcga gaagactata tcaaaagcaa aaggacaacc tagagaacct      1440
caagtgtaca cacttcctcc ttcaagagat gaacttacaa agaatcaggt gtcacttaca      1500
tgtttagtaa agggcttcta cccatctgac atcgcagtgg aatgggaatc aaacggacaa      1560
cctgagaata attataagac cactcctcct gtacttgatt cagatggatc attcttcctc      1620
tattcaaagt taaccgtgga taaatcaaga tggcaacaag gaaacgtgtt ctcctgttca      1680
gtgatgcacg aagcacttca caaccactac acacagaaga gtctatcact ttcacctgga      1740
tga                                                                    1743

<210>  2
<211>  580
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr 
            100                 105                 110         
Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 
Ser Gly Phe Ile Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala 
                165                 170                 175     
Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser 
            180                 185                 190         
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His 
        195                 200                 205             
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    210                 215                 220                 
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ala Tyr Gly Met Asp Val 
225                 230                 235                 240 
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                245                 250                 255     
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            260                 265                 270         
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        275                 280                 285             
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    290                 295                 300                 
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
305                 310                 315                 320 
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
                325                 330                 335     
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            340                 345                 350         
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        355                 360                 365             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    370                 375                 380                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
385                 390                 395                 400 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                405                 410                 415     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            420                 425                 430         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        435                 440                 445             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    450                 455                 460                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
465                 470                 475                 480 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                485                 490                 495     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            500                 505                 510         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        515                 520                 525             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    530                 535                 540                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
545                 550                 555                 560 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                565                 570                 575     
Leu Ser Pro Gly 
            580 

<210>  3
<211>  1017
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  3
gatatccaaa tgacccagag cccattgagc cttcctgtga cacctggaga acctgcatca        60
atctcatgca gatcatcaca atcacttctt gattcagatg atggaaacac ataccttgat       120
tggtaccttc agaagcccgg tcagtctcct cagctactaa tttatactct atcatacaga       180
gcatcgggcg taccggaccg cttctccgga tcagggtcag ggactgattt caccctaaag       240
atatccagag tggaagcaga agatgtggga gtgtactact gcatgcaaag aatcgaattt       300
cctcttacat ttggaggagg aacaaaggta gagatcaaag gtggaggagg atccggagga       360
ggtggatccg atatcgtgat gacgcagagc cctagctttc tttctgctag tgtaggcgac       420
agagtgacaa tcacatgcag agcatcacaa ggaatctcat cataccttgc atggtaccaa       480
cagaagccgg gaaaggcgcc caagctgctc atatatgctg cctcaactct gcagagtggc       540
gtgccgtctc gcttcagcgg tagcggatcg ggaacagagt ttacacttac aatctcatca       600
cttcaacctg aagatttcgc cacgtactac tgccaacaac ttaactcata ccctccttac       660
acatttggac aaggaacaaa gttagagatc aagcgaaccg tggcagcacc ttcagtgttt       720
atctttcctc cttcagatga acaacttaaa tcaggaactg cgtctgtagt ttgtcttctt       780
aacaacttct atccaagaga agcaaaggta cagtggaaag tggataacgc cctgcagtct       840
ggtaatagcc aagaatcagt gacagaacaa gattcaaagg acagtacata ctcactttca       900
tcaacactta cactttcaaa ggcggactac gagaagcata aggtgtacgc atgcgaagtg       960
acacaccaag gactttcatc acctgtgaca aagtccttca acagaggaga atgctga         1017

<210>  4
<211>  338
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      
Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
        115                 120                 125             
Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
    130                 135                 140                 
Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln 
145                 150                 155                 160 
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr 
                165                 170                 175     
Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         
Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
        195                 200                 205             
Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro Tyr Thr Phe Gly Gln 
    210                 215                 220                 
Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
225                 230                 235                 240 
Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
                245                 250                 255     
Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
            260                 265                 270         
Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
        275                 280                 285             
Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
    290                 295                 300                 
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
305                 310                 315                 320 
Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
                325                 330                 335     
Glu Cys 
        

<210>  5
<211>  2121
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  5
gaggtccagc tcgttgagtc cggtggggga ttggtgcaac ctggaggatc acttagactt        60
tcatgcgcag catcaggatt tatcgtgtca tcaaactaca tgtcatgggt acggcaggcg       120
ccagggaaag gcctagagtg ggtttcggtg atctactcag gaggatcaac atactacgca       180
gattcagtga aaggaagatt tacaatctca agacacaact caaagaatac tctttacctt       240
caaatgaact cacttagagc agaagacact gcggtgtact actgcgcacg ggaggcgtac       300
ggaatggatg tgtgggggca gggaacaaca gtcacggtct ctagcgccag caccaaaggc       360
ccgtctgtct ttccactcgc accttcatca aagagcacgt cgggagggac ggctgcgctt       420
ggatgtttag ttaaggacta tttcccagag ccggtcacag ttagctggaa ctcaggagca       480
cttacctcgg gcgttcacac ctttcctgca gtgcttcaat catcaggact ttactcactt       540
tcatcagtgg tgacagtgcc ttcatcatca cttggaacac aaacatacat ctgcaacgtg       600
aaccacaaac cttcaaacac aaaggtagac aagcgagtag aacctaaatc atgcgataag       660
acccatacat gccctccttg ccctgcacct gaacttcttg gaggtccatc ggtattctta       720
tttccgccaa agccgaagga tacacttatg atctcaagaa cacctgaagt gacatgcgtg       780
gtggtggatg tgtcacacga agatcctgaa gtgaaattta actggtacgt ggatggagtg       840
gaagtgcaca acgcaaagac gaagcctaga gaagaacaat acaactcaac atacagagtg       900
gtgtcagtgc ttacagtgct tcaccaagat tggcttaacg gaaaggagta taaatgcaaa       960
gtgtcaaaca aagcacttcc tgcacctatc gagaagacga tatcaaaagc aaaaggacaa      1020
cctagagaac ctcaagtgta cacacttcct ccttcaagag atgaacttac aaagaatcag      1080
gtgtcactta catgtttagt caagggcttc tacccttcag atatcgcagt ggaatgggaa      1140
tcaaacggac aacctgagaa taattataag actacaccac cggtgttgga cagtgacggg      1200
agcttcttcc tgtattcaaa gctcactgtg gataaatcaa gatggcaaca aggaaacgtg      1260
ttctcgtgtt cagtgatgca cgaagcactt cacaaccact acacacagaa gtcgctgtca      1320
ctttcacctg gtggtggaag tcaagttcag ttggtacaga gcggagcaga agtgaagaag      1380
cccggtgcga gtgtgaaagt gtcatgcaaa gcatcaggat acacatttac aggatactac      1440
atgcactggg tacgacaggc tccgggtcaa ggtttagagt ggatgggcag aatcaaccct      1500
aactctggag gcaccaacta cgcacagaag ttccagggaa gagtgacaat gacaagagat      1560
acatcaatct caacagcata catggaactt tcaagactta gatcagatga cactgcggtc      1620
tattattgtg cacgggtacc ttactgctca tcaacatcat gccacagaga ttggtacttt      1680
gatctttggg gaagaggaac acttgtcact gtgtcgtcag gaggcggagg atcagggggt      1740
gggggcagcg gcggtggcgg ttctggtgga ggtggcagcg acatccaaat gacacaatca      1800
cctctttcac ttcctgtgac acctggagaa cctgcatcaa tctcatgcag atcatcacaa      1860
tcacttctgg actcggacga cggcaacaca taccttgatt ggtaccttca gaagccgggt      1920
caatcacctc aacttcttat ctacacactt tcatacagag cgtccggagt cccggacaga      1980
ttcagcggtt caggatcagg aacagatttc acgttgaaga tttctagagt ggaagcagaa      2040
gatgtgggag tgtactactg catgcaaaga atcgaatttc ctcttacatt tggaggtggc      2100
acgaaagtgg agatcaaatg a                                                2121

<210>  6
<211>  706
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Glu Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gln 
        435                 440                 445             
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    450                 455                 460                 
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr 
465                 470                 475                 480 
Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                485                 490                 495     
Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
            500                 505                 510         
Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met 
        515                 520                 525             
Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
    530                 535                 540                 
Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr Phe 
545                 550                 555                 560 
Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                565                 570                 575     
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            580                 585                 590         
Ser Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
        595                 600                 605             
Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp 
    610                 615                 620                 
Ser Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly 
625                 630                 635                 640 
Gln Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly 
                645                 650                 655     
Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            660                 665                 670         
Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
        675                 680                 685             
Gln Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
    690                 695                 700                 
Ile Lys 
705     

<210>  7
<211>  648
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  7
gacatcgtga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc        60
atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca       120
gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca       180
aggttcagcg gcagtggatc tgggacagag ttcactctca caatcagcag cctgcagcct       240
gaagattttg caacttatta ctgtcaacag cttaatagtt accctccgta cacttttggc       300
caggggacca agctggagat caaacgaact gtggctgcac caagcgtgtt tatcttccct       360
cccagcgacg agcagctgaa gagcggcacc gccagcgtgg tctgtctcct gaacaacttc       420
tatcccaggg aggccaaggt ccagtggaaa gtggacaacg ccctgcaaag cggcaatagc       480
caggagtccg tcacagagca ggacagcaag gacagcacct acagcctgtc cagcaccctg       540
accctcagca aggccgacta cgagaagcac aaggtgtacg cttgcgaggt gacccatcag       600
ggcctgtcca gccccgtgac caagtccttc aacaggggcg aatgcagc                    648

<210>  8
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Ser 
    210                 215     

<210>  9
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Gly Phe Ile Val Ser Ser Asn Tyr 
1               5               

<210>  10
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Ile Tyr Ser Gly Gly Ser Thr 
1               5           

<210>  11
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Ala Arg Glu Ala Tyr Gly Met Asp Val 
1               5                   

<210>  12
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Gln Gly Ile Ser Ser Tyr 
1               5       

<210>  13
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Ala Ala Ser 
1           

<210>  14
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  14
Gln Gln Leu Asn Ser Tyr Pro Pro Tyr Thr 
1               5                   10  

<210>  15
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               

<210>  16
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  16
Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               

<210>  17
<211>  19
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr 
1               5                   10                  15      
Phe Asp Leu 
            

<210>  18
<211>  12
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  18
Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr 
1               5                   10          

<210>  19
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  19
Thr Leu Ser 
1           

<210>  20
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  20
Met Gln Arg Ile Glu Phe Pro Leu Thr 
1               5                   

<210>  21
<211>  259
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr 
            100                 105                 110         
Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
145                 150                 155                 160 
Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
                165                 170                 175     
Asp Ser Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
            180                 185                 190         
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser 
        195                 200                 205             
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    210                 215                 220                 
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
225                 230                 235                 240 
Met Gln Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
                245                 250                 255     
Glu Ile Lys 
            

<210>  22
<211>  57
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  22
atgggatggt catgcatcat cctattccta gtagcaacag caacaggagt gcactca           57

<210>  23
<211>  66
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  23
atggatatga gagtgcctgc acaacttctt ggacttcttc ttctttggct tcctggagca        60
agatgc                                                                   66

<210>  24
<211>  57
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  24
atgggatggt catgcatcat cctcttccta gtagcaacag caacaggagt gcactca           57

<210>  25
<211>  63
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  25
atggagacgg atacgctgct cctgtgggtt ttgctgctgt gggttccagg ttccactggt        60
gac                                                                      63

<210>  26
<211>  362
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  26
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Ser Phe 
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              
Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         
Leu Asn Ser Tyr Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             
Ile Lys Gly Gln Pro Lys Ala Ala Pro Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 
Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 
Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
                165                 170                 175     
Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
            180                 185                 190         
Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             
Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
    210                 215                 220                 
Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Ile Glu Phe Pro Leu Thr 
225                 230                 235                 240 
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Lys Gln Pro Ser Arg 
                245                 250                 255     
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
            260                 265                 270         
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
        275                 280                 285             
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
    290                 295                 300                 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
305                 310                 315                 320 
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
                325                 330                 335     
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
            340                 345                 350         
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360         

<210>  27
<211>  592
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  27
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg 
        115                 120                 125             
Asp Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 
Ser Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser 
                165                 170                 175     
Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         
Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
        195                 200                 205             
Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu 
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 
Cys Ala Arg Glu Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
                245                 250                 255     
Val Thr Val Ser Ser Arg Thr Ala Ser Thr Lys Gly Pro Ser Val Phe 
            260                 265                 270         
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
        275                 280                 285             
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
    290                 295                 300                 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
305                 310                 315                 320 
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
                325                 330                 335     
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
            340                 345                 350         
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
        355                 360                 365             
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    370                 375                 380                 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
385                 390                 395                 400 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                405                 410                 415     
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            420                 425                 430         
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        435                 440                 445             
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    450                 455                 460                 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
465                 470                 475                 480 
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                485                 490                 495     
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            500                 505                 510         
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        515                 520                 525             
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    530                 535                 540                 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
545                 550                 555                 560 
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                565                 570                 575     
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            580                 585                 590         

<210>  28
<211>  360
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  28
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Ser Phe 
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              
Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         
Leu Asn Ser Tyr Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             
Ile Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asp Ile Gln Met 
    130                 135                 140                 
Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
145                 150                 155                 160 
Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn 
                165                 170                 175     
Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu 
            180                 185                 190         
Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp Arg Phe 
        195                 200                 205             
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
    210                 215                 220                 
Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Ile Glu Phe 
225                 230                 235                 240 
Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
                245                 250                 255     
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         
Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 

<210>  29
<211>  598
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  29
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Met Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg 
        115                 120                 125             
Asp Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 
Ser Gly Gly Gly Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     
Ser Gly Phe Ile Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala 
            180                 185                 190         
Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser 
        195                 200                 205             
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His 
    210                 215                 220                 
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
225                 230                 235                 240 
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ala Tyr Gly Met Asp Val 
                245                 250                 255     
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Leu Ala Ser Thr 
            260                 265                 270         
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        275                 280                 285             
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    290                 295                 300                 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
305                 310                 315                 320 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                325                 330                 335     
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            340                 345                 350         
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        355                 360                 365             
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    370                 375                 380                 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
385                 390                 395                 400 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                405                 410                 415     
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            420                 425                 430         
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        435                 440                 445             
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    450                 455                 460                 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
465                 470                 475                 480 
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                485                 490                 495     
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            500                 505                 510         
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        515                 520                 525             
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    530                 535                 540                 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
545                 550                 555                 560 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                565                 570                 575     
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            580                 585                 590         
Leu Ser Leu Ser Pro Gly 
        595             

<210>  30
<211>  360
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  30
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Leu Ser 
            20                  25                  30          
Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              
Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr 
    50                  55                  60                  
Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser 
65                  70                  75                  80  
Tyr Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      
Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         
Val Tyr Tyr Cys Met Gln Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly 
        115                 120                 125             
Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    130                 135                 140                 
Gly Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val 
145                 150                 155                 160 
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
                165                 170                 175     
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
            180                 185                 190         
Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro 
225                 230                 235                 240 
Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
                245                 250                 255     
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         
Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 

<210>  31
<211>  596
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  31
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val 
        35                  40                  45              
Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr 
                85                  90                  95      
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Glu Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
        115                 120                 125             
Thr Val Thr Val Ser Ser Gly Gly Gly Gly Gly Gly Gly Gln Val Gln 
    130                 135                 140                 
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
145                 150                 155                 160 
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
                165                 170                 175     
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile 
            180                 185                 190         
Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg 
        195                 200                 205             
Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu 
    210                 215                 220                 
Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val 
225                 230                 235                 240 
Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr Phe Asp Leu 
                245                 250                 255     
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
            260                 265                 270         
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
        275                 280                 285             
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
    290                 295                 300                 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
305                 310                 315                 320 
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
                325                 330                 335     
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
            340                 345                 350         
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
        355                 360                 365             
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    370                 375                 380                 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
385                 390                 395                 400 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                405                 410                 415     
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            420                 425                 430         
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        435                 440                 445             
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    450                 455                 460                 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
465                 470                 475                 480 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                485                 490                 495     
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            500                 505                 510         
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        515                 520                 525             
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    530                 535                 540                 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
545                 550                 555                 560 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                565                 570                 575     
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            580                 585                 590         
Leu Ser Pro Gly 
        595     

<210>  32
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Glu Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  33
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  33
Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210>  34
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  34
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr 
            100                 105                 110         
Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210>  35
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  35
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      
Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys 
    

