﻿                         序列表

<110>  百奥泰生物制药股份有限公司

<120>  抗HER2抗体及其应用

<150>  CN202010739418.X
<151>  2020-07-28

<160>  13

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gly Phe Thr Phe Thr Asp Tyr Thr 
1               5               

<210>  2
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15  

<210>  3
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   

<210>  4
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala 
1               5                   10      

<210>  5
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Ala Ser Tyr Arg Tyr Thr Gly 
1               5           

<210>  6
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe 
1               5                   10  

<210>  7
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  8
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             

<210>  9
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  10
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  11
<211>  636
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      
Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          
Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              
Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  
Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  
Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      
Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         
Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             
Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 
Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 
Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     
Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         
Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             
Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 
Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 
Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     
Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         
Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             
Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 
Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 
Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     
Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         
Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             
Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 
Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 
Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
                405                 410                 415     
Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         
Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             
Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 
Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 
Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     
His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         
Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             
Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 
Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 
Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     
Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         
Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             
Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 
Arg Ala Ser Pro Leu Thr His His His His His His 
625                 630                 635     

<210>  12
<211>  642
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  12
gatatccaga tgacccagag cccttcctcc ctgagcgcta gcgtgggcga ccgggtgacc        60
atcacctgca aggctagcca ggacgtgtcc atcggcgtgg cctggtacca gcagaagccc       120
ggcaaggccc ccaagctgct gatctactcc gcttcctatc ggtataccgg cgtgccttcc       180
aggttctccg gcagcggctc cggcaccgac ttcaccctga ccatctcctc cctgcagcct       240
gaggacttcg ccacctacta ctgtcagcag tactacatct acccttacac cttcggccag       300
ggcaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca       360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat       420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag       480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg       540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc       600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                          642

<210>  13
<211>  1347
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  13
gaggtgcagc tggtggagtc cggcggcgga ctggtgcagc caggaggaag cctgaggctg        60
tcctgcgccg ctagcggctt caccttcacc gattacacca tggactgggt gaggcaggcc       120
cctggcaagg gcctggagtg ggtggctgac gtgaatccca atagcggcgg ctccatctac       180
aatcagaggt tcaagggcag gtttaccctg tccgtggata ggagcaagaa taccctgtac       240
ctgcagatga actccctgag ggccgaggac accgccgtgt attattgtgc tcggaatctg       300
ggccctagct tttatttcga ttattggggc cagggtaccc tggtcaccgt gtctagtgct       360
agtactaagg ggccttcagt gtttccactg gcaccctcat ccaaatccac cagcggcgga       420
acagcagccc tgggttgtct ggtgaaggac tacttcccag aacccgtcac cgtgtcatgg       480
aactccggcg cactgacatc tggagtccac acttttcctg ccgtgctgca gagctctggg       540
ctgtactccc tgagttcagt ggtcactgtc ccatccagct ctctgggtac acagacttat       600
atctgcaacg tgaatcacaa gccaagtaat accaaagtcg acaagaaagt ggagcccaag       660
tcatgtgata aaacccatac atgcccccct tgtcctgcac cagaactgct gggaggtcca       720
agcgtgttcc tgtttccacc caagcctaaa gacacactga tgattagtag gactcccgag       780
gtcacctgcg tggtcgtgga cgtgtcccac gaggatcctg aagtcaagtt taactggtac       840
gtggatggcg tcgaagtgca taatgctaag accaaaccaa gagaggaaca gtacaactcc       900
acttatcgcg tcgtgagcgt cctgaccgtg ctgcatcagg attggctgaa cggcaaggag       960
tataagtgca aagtgagcaa taaggctctg cccgcaccta tcgagaaaac catttctaag      1020
gcaaaaggac agcctcgaga accacaggtg tacacactgc ctccaagccg tgaggaaatg      1080
accaagaacc aggtctctct gacatgtctg gtgaaaggct tctatccttc agacattgct      1140
gtggagtggg aatccaatgg acagccagag aacaattaca agaccacacc ccctgtgctg      1200
gacagcgatg gctctttctt tctgtattct aagctgaccg tggataaaag tcggtggcag      1260
cagggaaatg tcttttcttg tagtgtgatg cacgaagcac tgcacaacca ctacacccag      1320
aaatcactgt cactgtctcc agggaag                                          1347

