                         SEQUENCE LISTING

<110>  Stream Biomedical, Inc.
 
<120>  USE OF PERLECAN AND FRAGMENTS THEREOF TO REDUCE THE RISK OF DEATH
        IN STROKE PATIENTS

<130>  STRM.P0003WO

<140>  Filed Concurrently Herewith
<141>  2021-07-26

<150>  US 63/056,059
<151>  2020-07-24

<150>  US 63/061,308
<151>  2020-08-05

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  4391
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 
            500                 505                 510         


Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser 
        515                 520                 525             


Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe 
    530                 535                 540                 


Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln 
545                 550                 555                 560 


Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser 
                565                 570                 575     


Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val His 
            580                 585                 590         


Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val Asp 
        595                 600                 605             


Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala Arg 
    610                 615                 620                 


Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Met Gly Ala 
625                 630                 635                 640 


Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala 
                645                 650                 655     


Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu 
            660                 665                 670         


Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser 
        675                 680                 685             


Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala Ser 
    690                 695                 700                 


Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala Thr 
705                 710                 715                 720 


Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly 
                725                 730                 735     


Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val 
            740                 745                 750         


Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn Gly 
        755                 760                 765             


His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 
    770                 775                 780                 


His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe 
785                 790                 795                 800 


Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro Cys 
                805                 810                 815     


Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp 
            820                 825                 830         


Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly 
        835                 840                 845             


Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln 
    850                 855                 860                 


Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys Asp 
865                 870                 875                 880 


Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn 
                885                 890                 895     


Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His 
            900                 905                 910         


Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly 
        915                 920                 925             


Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu His 
    930                 935                 940                 


Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala Ser 
945                 950                 955                 960 


Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu 
                965                 970                 975     


Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser 
            980                 985                 990         


Leu Pro Ser Arg Phe Leu Gly Asp  Lys Val Thr Ser Tyr  Gly Gly Glu 
        995                 1000                 1005             


Leu Arg  Phe Thr Val Thr Gln  Arg Ser Gln Pro Gly  Ser Thr Pro 
    1010                 1015                 1020             


Leu His  Gly Gln Pro Leu Val  Val Leu Gln Gly Asn  Asn Ile Ile 
    1025                 1030                 1035             


Leu Glu  His His Val Ala Gln  Glu Pro Ser Pro Gly  Gln Pro Ser 
    1040                 1045                 1050             


Thr Phe  Ile Val Pro Phe Arg  Glu Gln Ala Trp Gln  Arg Pro Asp 
    1055                 1060                 1065             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Gly 
    1070                 1075                 1080             


Ile Asp  Thr Leu Leu Ile Arg  Ala Ser Tyr Ala Gln  Gln Pro Ala 
    1085                 1090                 1095             


Glu Ser  Arg Val Ser Gly Ile  Ser Met Asp Val Ala  Val Pro Glu 
    1100                 1105                 1110             


Glu Thr  Gly Gln Asp Pro Ala  Leu Glu Val Glu Gln  Cys Ser Cys 
    1115                 1120                 1125             


Pro Pro  Gly Tyr Arg Gly Pro  Ser Cys Gln Asp Cys  Asp Thr Gly 
    1130                 1135                 1140             


Tyr Thr  Arg Thr Pro Ser Gly  Leu Tyr Leu Gly Thr  Cys Glu Arg 
    1145                 1150                 1155             


Cys Ser  Cys His Gly His Ser  Glu Ala Cys Glu Pro  Glu Thr Gly 
    1160                 1165                 1170             


Ala Cys  Gln Gly Cys Gln His  His Thr Glu Gly Pro  Arg Cys Glu 
    1175                 1180                 1185             


Gln Cys  Gln Pro Gly Tyr Tyr  Gly Asp Ala Gln Arg  Gly Thr Pro 
    1190                 1195                 1200             


Gln Asp  Cys Gln Leu Cys Pro  Cys Tyr Gly Asp Pro  Ala Ala Gly 
    1205                 1210                 1215             


Gln Ala  Ala His Thr Cys Phe  Leu Asp Thr Asp Gly  His Pro Thr 
    1220                 1225                 1230             


Cys Asp  Ala Cys Ser Pro Gly  His Ser Gly Arg His  Cys Glu Arg 
    1235                 1240                 1245             


Cys Ala  Pro Gly Tyr Tyr Gly  Asn Pro Ser Gln Gly  Gln Pro Cys 
    1250                 1255                 1260             


Gln Arg  Asp Ser Gln Val Pro  Gly Pro Ile Gly Cys  Asn Cys Asp 
    1265                 1270                 1275             


Pro Gln  Gly Ser Val Ser Ser  Gln Cys Asp Ala Ala  Gly Gln Cys 
    1280                 1285                 1290             


Gln Cys  Lys Ala Gln Val Glu  Gly Leu Thr Cys Ser  His Cys Arg 
    1295                 1300                 1305             


Pro His  His Phe His Leu Ser  Ala Ser Asn Pro Asp  Gly Cys Leu 
    1310                 1315                 1320             


Pro Cys  Phe Cys Met Gly Ile  Thr Gln Gln Cys Ala  Ser Ser Ala 
    1325                 1330                 1335             


Tyr Thr  Arg His Leu Ile Ser  Thr His Phe Ala Pro  Gly Asp Phe 
    1340                 1345                 1350             


Gln Gly  Phe Ala Leu Val Asn  Pro Gln Arg Asn Ser  Arg Leu Thr 
    1355                 1360                 1365             


Gly Glu  Phe Thr Val Glu Pro  Val Pro Glu Gly Ala  Gln Leu Ser 
    1370                 1375                 1380             


Phe Gly  Asn Phe Ala Gln Leu  Gly His Glu Ser Phe  Tyr Trp Gln 
    1385                 1390                 1395             


Leu Pro  Glu Thr Tyr Gln Gly  Asp Lys Val Ala Ala  Tyr Gly Gly 
    1400                 1405                 1410             


Lys Leu  Arg Tyr Thr Leu Ser  Tyr Thr Ala Gly Pro  Gln Gly Ser 
    1415                 1420                 1425             


Pro Leu  Ser Asp Pro Asp Val  Gln Ile Thr Gly Asn  Asn Ile Met 
    1430                 1435                 1440             


Leu Val  Ala Ser Gln Pro Ala  Leu Gln Gly Pro Glu  Arg Arg Ser 
    1445                 1450                 1455             


Tyr Glu  Ile Met Phe Arg Glu  Glu Phe Trp Arg Arg  Pro Asp Gly 
    1460                 1465                 1470             


Gln Pro  Ala Thr Arg Glu His  Leu Leu Met Ala Leu  Ala Asp Leu 
    1475                 1480                 1485             


Asp Glu  Leu Leu Ile Arg Ala  Thr Phe Ser Ser Val  Pro Leu Ala 
    1490                 1495                 1500             


Ala Ser  Ile Ser Ala Val Ser  Leu Glu Val Ala Gln  Pro Gly Pro 
    1505                 1510                 1515             


Ser Asn  Arg Pro Arg Ala Leu  Glu Val Glu Glu Cys  Arg Cys Pro 
    1520                 1525                 1530             


Pro Gly  Tyr Ile Gly Leu Ser  Cys Gln Asp Cys Ala  Pro Gly Tyr 
    1535                 1540                 1545             


Thr Arg  Thr Gly Ser Gly Leu  Tyr Leu Gly His Cys  Glu Leu Cys 
    1550                 1555                 1560             


Glu Cys  Asn Gly His Ser Asp  Leu Cys His Pro Glu  Thr Gly Ala 
    1565                 1570                 1575             


Cys Ser  Gln Cys Gln His Asn  Ala Ala Gly Glu Phe  Cys Glu Leu 
    1580                 1585                 1590             


Cys Ala  Pro Gly Tyr Tyr Gly  Asp Ala Thr Ala Gly  Thr Pro Glu 
    1595                 1600                 1605             


Asp Cys  Gln Pro Cys Ala Cys  Pro Leu Thr Asn Pro  Glu Asn Met 
    1610                 1615                 1620             


Phe Ser  Arg Thr Cys Glu Ser  Leu Gly Ala Gly Gly  Tyr Arg Cys 
    1625                 1630                 1635             


Thr Ala  Cys Glu Pro Gly Tyr  Thr Gly Gln Tyr Cys  Glu Gln Cys 
    1640                 1645                 1650             


Gly Pro  Gly Tyr Val Gly Asn  Pro Ser Val Gln Gly  Gly Gln Cys 
    1655                 1660                 1665             


Leu Pro  Glu Thr Asn Gln Ala  Pro Leu Val Val Glu  Val His Pro 
    1670                 1675                 1680             


Ala Arg  Ser Ile Val Pro Gln  Gly Gly Ser His Ser  Leu Arg Cys 
    1685                 1690                 1695             


Gln Val  Ser Gly Ser Pro Pro  His Tyr Phe Tyr Trp  Ser Arg Glu 
    1700                 1705                 1710             


Asp Gly  Arg Pro Val Pro Ser  Gly Thr Gln Gln Arg  His Gln Gly 
    1715                 1720                 1725             


Ser Glu  Leu His Phe Pro Ser  Val Gln Pro Ser Asp  Ala Gly Val 
    1730                 1735                 1740             


Tyr Ile  Cys Thr Cys Arg Asn  Leu His Gln Ser Asn  Thr Ser Arg 
    1745                 1750                 1755             


Ala Glu  Leu Leu Val Thr Glu  Ala Pro Ser Lys Pro  Ile Thr Val 
    1760                 1765                 1770             


Thr Val  Glu Glu Gln Arg Ser  Gln Ser Val Arg Pro  Gly Ala Asp 
    1775                 1780                 1785             


Val Thr  Phe Ile Cys Thr Ala  Lys Ser Lys Ser Pro  Ala Tyr Thr 
    1790                 1795                 1800             


Leu Val  Trp Thr Arg Leu His  Asn Gly Lys Leu Pro  Thr Arg Ala 
    1805                 1810                 1815             


Met Asp  Phe Asn Gly Ile Leu  Thr Ile Arg Asn Val  Gln Leu Ser 
    1820                 1825                 1830             


Asp Ala  Gly Thr Tyr Val Cys  Thr Gly Ser Asn Met  Phe Ala Met 
    1835                 1840                 1845             


Asp Gln  Gly Thr Ala Thr Leu  His Val Gln Ala Ser  Gly Thr Leu 
    1850                 1855                 1860             


Ser Ala  Pro Val Val Ser Ile  His Pro Pro Gln Leu  Thr Val Gln 
    1865                 1870                 1875             


Pro Gly  Gln Leu Ala Glu Phe  Arg Cys Ser Ala Thr  Gly Ser Pro 
    1880                 1885                 1890             


Thr Pro  Thr Leu Glu Trp Thr  Gly Gly Pro Gly Gly  Gln Leu Pro 
    1895                 1900                 1905             


Ala Lys  Ala Gln Ile His Gly  Gly Ile Leu Arg Leu  Pro Ala Val 
    1910                 1915                 1920             


Glu Pro  Thr Asp Gln Ala Gln  Tyr Leu Cys Arg Ala  His Ser Ser 
    1925                 1930                 1935             


Ala Gly  Gln Gln Val Ala Arg  Ala Val Leu His Val  His Gly Gly 
    1940                 1945                 1950             


Gly Gly  Pro Arg Val Gln Val  Ser Pro Glu Arg Thr  Gln Val His 
    1955                 1960                 1965             


Ala Gly  Arg Thr Val Arg Leu  Tyr Cys Arg Ala Ala  Gly Val Pro 
    1970                 1975                 1980             


Ser Ala  Thr Ile Thr Trp Arg  Lys Glu Gly Gly Ser  Leu Pro Pro 
    1985                 1990                 1995             


Gln Ala  Arg Ser Glu Arg Thr  Asp Ile Ala Thr Leu  Leu Ile Pro 
    2000                 2005                 2010             


Ala Ile  Thr Thr Ala Asp Ala  Gly Phe Tyr Leu Cys  Val Ala Thr 
    2015                 2020                 2025             


Ser Pro  Ala Gly Thr Ala Gln  Ala Arg Ile Gln Val  Val Val Leu 
    2030                 2035                 2040             


Ser Ala  Ser Asp Ala Ser Pro  Pro Pro Val Lys Ile  Glu Ser Ser 
    2045                 2050                 2055             


Ser Pro  Ser Val Thr Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val 
    2060                 2065                 2070             


Val Ala  Gly Ser Ala His Ala  Gln Val Thr Trp Tyr  Arg Arg Gly 
    2075                 2080                 2085             


Gly Ser  Leu Pro Pro His Thr  Gln Val His Gly Ser  Arg Leu Arg 
    2090                 2095                 2100             


Leu Pro  Gln Val Ser Pro Ala  Asp Ser Gly Glu Tyr  Val Cys Arg 
    2105                 2110                 2115             


Val Glu  Asn Gly Ser Gly Pro  Lys Glu Ala Ser Ile  Thr Val Ser 
    2120                 2125                 2130             


Val Leu  His Gly Thr His Ser  Gly Pro Ser Tyr Thr  Pro Val Pro 
    2135                 2140                 2145             


Gly Ser  Thr Arg Pro Ile Arg  Ile Glu Pro Ser Ser  Ser His Val 
    2150                 2155                 2160             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln 
    2165                 2170                 2175             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2180                 2185                 2190             


Ala Arg  His Gln Thr His Gly  Ser Leu Leu Arg Leu  His Gln Val 
    2195                 2200                 2205             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys His Val  Val Gly Thr 
    2210                 2215                 2220             


Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Ala Ser 
    2225                 2230                 2235             


Val Ile  Pro Gly Pro Ile Pro  Pro Val Arg Ile Glu  Ser Ser Ser 
    2240                 2245                 2250             


Ser Thr  Val Ala Glu Gly Gln  Thr Leu Asp Leu Ser  Cys Val Val 
    2255                 2260                 2265             


Ala Gly  Gln Ala His Ala Gln  Val Thr Trp Tyr Lys  Arg Gly Gly 
    2270                 2275                 2280             


Ser Leu  Pro Ala Arg His Gln  Val Arg Gly Ser Arg  Leu Tyr Ile 
    2285                 2290                 2295             


Phe Gln  Ala Ser Pro Ala Asp  Ala Gly Gln Tyr Val  Cys Arg Ala 
    2300                 2305                 2310             


Ser Asn  Gly Met Glu Ala Ser  Ile Thr Val Thr Val  Thr Gly Thr 
    2315                 2320                 2325             


Gln Gly  Ala Asn Leu Ala Tyr  Pro Ala Gly Ser Thr  Gln Pro Ile 
    2330                 2335                 2340             


Arg Ile  Glu Pro Ser Ser Ser  Gln Val Ala Glu Gly  Gln Thr Leu 
    2345                 2350                 2355             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ser His Ala  Gln Val Thr 
    2360                 2365                 2370             


Trp His  Lys Arg Gly Gly Ser  Leu Pro Val Arg His  Gln Thr His 
    2375                 2380                 2385             


Gly Ser  Leu Leu Arg Leu Tyr  Gln Ala Ser Pro Ala  Asp Ser Gly 
    2390                 2395                 2400             


Glu Tyr  Val Cys Arg Val Leu  Gly Ser Ser Val Pro  Leu Glu Ala 
    2405                 2410                 2415             


Ser Val  Leu Val Thr Ile Glu  Pro Ala Gly Ser Val  Pro Ala Leu 
    2420                 2425                 2430             


Gly Val  Thr Pro Thr Val Arg  Ile Glu Ser Ser Ser  Ser Gln Val 
    2435                 2440                 2445             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Leu Val  Ala Gly Gln 
    2450                 2455                 2460             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2465                 2470                 2475             


Ala Arg  His Gln Val His Gly  Ser Arg Leu Arg Leu  Leu Gln Val 
    2480                 2485                 2490             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys Arg Val  Val Gly Ser 
    2495                 2500                 2505             


Ser Gly  Thr Gln Glu Ala Ser  Val Leu Val Thr Ile  Gln Gln Arg 
    2510                 2515                 2520             


Leu Ser  Gly Ser His Ser Gln  Gly Val Ala Tyr Pro  Val Arg Ile 
    2525                 2530                 2535             


Glu Ser  Ser Ser Ala Ser Leu  Ala Asn Gly His Thr  Leu Asp Leu 
    2540                 2545                 2550             


Asn Cys  Leu Val Ala Ser Gln  Ala Pro His Thr Ile  Thr Trp Tyr 
    2555                 2560                 2565             


Lys Arg  Gly Gly Ser Leu Pro  Ser Arg His Gln Ile  Val Gly Ser 
    2570                 2575                 2580             


Arg Leu  Arg Ile Pro Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr 
    2585                 2590                 2595             


Val Cys  His Val Ser Asn Gly  Ala Gly Ser Arg Glu  Thr Ser Leu 
    2600                 2605                 2610             


Ile Val  Thr Ile Gln Gly Ser  Gly Ser Ser His Val  Pro Ser Val 
    2615                 2620                 2625             


Ser Pro  Pro Ile Arg Ile Glu  Ser Ser Ser Pro Thr  Val Val Glu 
    2630                 2635                 2640             


Gly Gln  Thr Leu Asp Leu Asn  Cys Val Val Ala Arg  Gln Pro Gln 
    2645                 2650                 2655             


Ala Ile  Ile Thr Trp Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg 
    2660                 2665                 2670             


His Gln  Thr His Gly Ser His  Leu Arg Leu His Gln  Met Ser Val 
    2675                 2680                 2685             


Ala Asp  Ser Gly Glu Tyr Val  Cys Arg Ala Asn Asn  Asn Ile Asp 
    2690                 2695                 2700             


Ala Leu  Glu Ala Ser Ile Val  Ile Ser Val Ser Pro  Ser Ala Gly 
    2705                 2710                 2715             


Ser Pro  Ser Ala Pro Gly Ser  Ser Met Pro Ile Arg  Ile Glu Ser 
    2720                 2725                 2730             


Ser Ser  Ser His Val Ala Glu  Gly Glu Thr Leu Asp  Leu Asn Cys 
    2735                 2740                 2745             


Val Val  Pro Gly Gln Ala His  Ala Gln Val Thr Trp  His Lys Arg 
    2750                 2755                 2760             


Gly Gly  Ser Leu Pro Ser His  His Gln Thr Arg Gly  Ser Arg Leu 
    2765                 2770                 2775             


Arg Leu  His His Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2780                 2785                 2790             


Arg Val  Met Gly Ser Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val 
    2795                 2800                 2805             


Thr Ile  Glu Ala Ser Gly Ser  Ser Ala Val His Val  Pro Ala Pro 
    2810                 2815                 2820             


Gly Gly  Ala Pro Pro Ile Arg  Ile Glu Pro Ser Ser  Ser Arg Val 
    2825                 2830                 2835             


Ala Glu  Gly Gln Thr Leu Asp  Leu Lys Cys Val Val  Pro Gly Gln 
    2840                 2845                 2850             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Asn Leu Pro 
    2855                 2860                 2865             


Ala Arg  His Gln Val His Gly  Pro Leu Leu Arg Leu  Asn Gln Val 
    2870                 2875                 2880             


Ser Pro  Ala Asp Ser Gly Glu  Tyr Ser Cys Gln Val  Thr Gly Ser 
    2885                 2890                 2895             


Ser Gly  Thr Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Pro Ser 
    2900                 2905                 2910             


Ser Pro  Gly Pro Ile Pro Ala  Pro Gly Leu Ala Gln  Pro Ile Tyr 
    2915                 2920                 2925             


Ile Glu  Ala Ser Ser Ser His  Val Thr Glu Gly Gln  Thr Leu Asp 
    2930                 2935                 2940             


Leu Asn  Cys Val Val Pro Gly  Gln Ala His Ala Gln  Val Thr Trp 
    2945                 2950                 2955             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ala Arg His Gln  Thr His Gly 
    2960                 2965                 2970             


Ser Gln  Leu Arg Leu His Leu  Val Ser Pro Ala Asp  Ser Gly Glu 
    2975                 2980                 2985             


Tyr Val  Cys Arg Ala Ala Ser  Gly Pro Gly Pro Glu  Gln Glu Ala 
    2990                 2995                 3000             


Ser Phe  Thr Val Thr Val Pro  Pro Ser Glu Gly Ser  Ser Tyr Arg 
    3005                 3010                 3015             


Leu Arg  Ser Pro Val Ile Ser  Ile Asp Pro Pro Ser  Ser Thr Val 
    3020                 3025                 3030             


Gln Gln  Gly Gln Asp Ala Ser  Phe Lys Cys Leu Ile  His Asp Gly 
    3035                 3040                 3045             


Ala Ala  Pro Ile Ser Leu Glu  Trp Lys Thr Arg Asn  Gln Glu Leu 
    3050                 3055                 3060             


Glu Asp  Asn Val His Ile Ser  Pro Asn Gly Ser Ile  Ile Thr Ile 
    3065                 3070                 3075             


Val Gly  Thr Arg Pro Ser Asn  His Gly Thr Tyr Arg  Cys Val Ala 
    3080                 3085                 3090             


Ser Asn  Ala Tyr Gly Val Ala  Gln Ser Val Val Asn  Leu Ser Val 
    3095                 3100                 3105             


His Gly  Pro Pro Thr Val Ser  Val Leu Pro Glu Gly  Pro Val Trp 
    3110                 3115                 3120             


Val Lys  Val Gly Lys Ala Val  Thr Leu Glu Cys Val  Ser Ala Gly 
    3125                 3130                 3135             


Glu Pro  Arg Ser Ser Ala Arg  Trp Thr Arg Ile Ser  Ser Thr Pro 
    3140                 3145                 3150             


Ala Lys  Leu Glu Gln Arg Thr  Tyr Gly Leu Met Asp  Ser His Ala 
    3155                 3160                 3165             


Val Leu  Gln Ile Ser Ser Ala  Lys Pro Ser Asp Ala  Gly Thr Tyr 
    3170                 3175                 3180             


Val Cys  Leu Ala Gln Asn Ala  Leu Gly Thr Ala Gln  Lys Gln Val 
    3185                 3190                 3195             


Glu Val  Ile Val Asp Thr Gly  Ala Met Ala Pro Gly  Ala Pro Gln 
    3200                 3205                 3210             


Val Gln  Ala Glu Glu Ala Glu  Leu Thr Val Glu Ala  Gly His Thr 
    3215                 3220                 3225             


Ala Thr  Leu Arg Cys Ser Ala  Thr Gly Ser Pro Ala  Pro Thr Ile 
    3230                 3235                 3240             


His Trp  Ser Lys Leu Arg Ser  Pro Leu Pro Trp Gln  His Arg Leu 
    3245                 3250                 3255             


Glu Gly  Asp Thr Leu Ile Ile  Pro Arg Val Ala Gln  Gln Asp Ser 
    3260                 3265                 3270             


Gly Gln  Tyr Ile Cys Asn Ala  Thr Ser Pro Ala Gly  His Ala Glu 
    3275                 3280                 3285             


Ala Thr  Ile Ile Leu His Val  Glu Ser Pro Pro Tyr  Ala Thr Thr 
    3290                 3295                 3300             


Val Pro  Glu His Ala Ser Val  Gln Ala Gly Glu Thr  Val Gln Leu 
    3305                 3310                 3315             


Gln Cys  Leu Ala His Gly Thr  Pro Pro Leu Thr Phe  Gln Trp Ser 
    3320                 3325                 3330             


Arg Val  Gly Ser Ser Leu Pro  Gly Arg Ala Thr Ala  Arg Asn Glu 
    3335                 3340                 3345             


Leu Leu  His Phe Glu Arg Ala  Ala Pro Glu Asp Ser  Gly Arg Tyr 
    3350                 3355                 3360             


Arg Cys  Arg Val Thr Asn Lys  Val Gly Ser Ala Glu  Ala Phe Ala 
    3365                 3370                 3375             


Gln Leu  Leu Val Gln Gly Pro  Pro Gly Ser Leu Pro  Ala Thr Ser 
    3380                 3385                 3390             


Ile Pro  Ala Gly Ser Thr Pro  Thr Val Gln Val Thr  Pro Gln Leu 
    3395                 3400                 3405             


Glu Thr  Lys Ser Ile Gly Ala  Ser Val Glu Phe His  Cys Ala Val 
    3410                 3415                 3420             


Pro Ser  Asp Arg Gly Thr Gln  Leu Arg Trp Phe Lys  Glu Gly Gly 
    3425                 3430                 3435             


Gln Leu  Pro Pro Gly His Ser  Val Gln Asp Gly Val  Leu Arg Ile 
    3440                 3445                 3450             


Gln Asn  Leu Asp Gln Ser Cys  Gln Gly Thr Tyr Ile  Cys Gln Ala 
    3455                 3460                 3465             


His Gly  Pro Trp Gly Lys Ala  Gln Ala Ser Ala Gln  Leu Val Ile 
    3470                 3475                 3480             


Gln Ala  Leu Pro Ser Val Leu  Ile Asn Ile Arg Thr  Ser Val Gln 
    3485                 3490                 3495             


Thr Val  Val Val Gly His Ala  Val Glu Phe Glu Cys  Leu Ala Leu 
    3500                 3505                 3510             


Gly Asp  Pro Lys Pro Gln Val  Thr Trp Ser Lys Val  Gly Gly His 
    3515                 3520                 3525             


Leu Arg  Pro Gly Ile Val Gln  Ser Gly Gly Val Val  Arg Ile Ala 
    3530                 3535                 3540             


His Val  Glu Leu Ala Asp Ala  Gly Gln Tyr Arg Cys  Thr Ala Thr 
    3545                 3550                 3555             


Asn Ala  Ala Gly Thr Thr Gln  Ser His Val Leu Leu  Leu Val Gln 
    3560                 3565                 3570             


Ala Leu  Pro Gln Ile Ser Met  Pro Gln Glu Val Arg  Val Pro Ala 
    3575                 3580                 3585             


Gly Ser  Ala Ala Val Phe Pro  Cys Ile Ala Ser Gly  Tyr Pro Thr 
    3590                 3595                 3600             


Pro Asp  Ile Ser Trp Ser Lys  Leu Asp Gly Ser Leu  Pro Pro Asp 
    3605                 3610                 3615             


Ser Arg  Leu Glu Asn Asn Met  Leu Met Leu Pro Ser  Val Arg Pro 
    3620                 3625                 3630             


Gln Asp  Ala Gly Thr Tyr Val  Cys Thr Ala Thr Asn  Arg Gln Gly 
    3635                 3640                 3645             


Lys Val  Lys Ala Phe Ala His  Leu Gln Val Pro Glu  Arg Val Val 
    3650                 3655                 3660             


Pro Tyr  Phe Thr Gln Thr Pro  Tyr Ser Phe Leu Pro  Leu Pro Thr 
    3665                 3670                 3675             


Ile Lys  Asp Ala Tyr Arg Lys  Phe Glu Ile Lys Ile  Thr Phe Arg 
    3680                 3685                 3690             


Pro Asp  Ser Ala Asp Gly Met  Leu Leu Tyr Asn Gly  Gln Lys Arg 
    3695                 3700                 3705             


Val Pro  Gly Ser Pro Thr Asn  Leu Ala Asn Arg Gln  Pro Asp Phe 
    3710                 3715                 3720             


Ile Ser  Phe Gly Leu Val Gly  Gly Arg Pro Glu Phe  Arg Phe Asp 
    3725                 3730                 3735             


Ala Gly  Ser Gly Met Ala Thr  Ile Arg His Pro Thr  Pro Leu Ala 
    3740                 3745                 3750             


Leu Gly  His Phe His Thr Val  Thr Leu Leu Arg Ser  Leu Thr Gln 
    3755                 3760                 3765             


Gly Ser  Leu Ile Val Gly Asp  Leu Ala Pro Val Asn  Gly Thr Ser 
    3770                 3775                 3780             


Gln Gly  Lys Phe Gln Gly Leu  Asp Leu Asn Glu Glu  Leu Tyr Leu 
    3785                 3790                 3795             


Gly Gly  Tyr Pro Asp Tyr Gly  Ala Ile Pro Lys Ala  Gly Leu Ser 
    3800                 3805                 3810             


Ser Gly  Phe Ile Gly Cys Val  Arg Glu Leu Arg Ile  Gln Gly Glu 
    3815                 3820                 3825             


Glu Ile  Val Phe His Asp Leu  Asn Leu Thr Ala His  Gly Ile Ser 
    3830                 3835                 3840             


His Cys  Pro Thr Cys Arg Asp  Arg Pro Cys Gln Asn  Gly Gly Gln 
    3845                 3850                 3855             


Cys His  Asp Ser Glu Ser Ser  Ser Tyr Val Cys Val  Cys Pro Ala 
    3860                 3865                 3870             


Gly Phe  Thr Gly Ser Arg Cys  Glu His Ser Gln Ala  Leu His Cys 
    3875                 3880                 3885             


His Pro  Glu Ala Cys Gly Pro  Asp Ala Thr Cys Val  Asn Arg Pro 
    3890                 3895                 3900             


Asp Gly  Arg Gly Tyr Thr Cys  Arg Cys His Leu Gly  Arg Ser Gly 
    3905                 3910                 3915             


Leu Arg  Cys Glu Glu Gly Val  Thr Val Thr Thr Pro  Ser Leu Ser 
    3920                 3925                 3930             


Gly Ala  Gly Ser Tyr Leu Ala  Leu Pro Ala Leu Thr  Asn Thr His 
    3935                 3940                 3945             


His Glu  Leu Arg Leu Asp Val  Glu Phe Lys Pro Leu  Ala Pro Asp 
    3950                 3955                 3960             


Gly Val  Leu Leu Phe Ser Gly  Gly Lys Ser Gly Pro  Val Glu Asp 
    3965                 3970                 3975             


Phe Val  Ser Leu Ala Met Val  Gly Gly His Leu Glu  Phe Arg Tyr 
    3980                 3985                 3990             


Glu Leu  Gly Ser Gly Leu Ala  Val Leu Arg Ser Ala  Glu Pro Leu 
    3995                 4000                 4005             


Ala Leu  Gly Arg Trp His Arg  Val Ser Ala Glu Arg  Leu Asn Lys 
    4010                 4015                 4020             


Asp Gly  Ser Leu Arg Val Asn  Gly Gly Arg Pro Val  Leu Arg Ser 
    4025                 4030                 4035             


Ser Pro  Gly Lys Ser Gln Gly  Leu Asn Leu His Thr  Leu Leu Tyr 
    4040                 4045                 4050             


Leu Gly  Gly Val Glu Pro Ser  Val Pro Leu Ser Pro  Ala Thr Asn 
    4055                 4060                 4065             


Met Ser  Ala His Phe Arg Gly  Cys Val Gly Glu Val  Ser Val Asn 
    4070                 4075                 4080             


Gly Lys  Arg Leu Asp Leu Thr  Tyr Ser Phe Leu Gly  Ser Gln Gly 
    4085                 4090                 4095             


Ile Gly  Gln Cys Tyr Asp Ser  Ser Pro Cys Glu Arg  Gln Pro Cys 
    4100                 4105                 4110             


Gln His  Gly Ala Thr Cys Met  Pro Ala Gly Glu Tyr  Glu Phe Gln 
    4115                 4120                 4125             


Cys Leu  Cys Arg Asp Gly Phe  Lys Gly Asp Leu Cys  Glu His Glu 
    4130                 4135                 4140             


Glu Asn  Pro Cys Gln Leu Arg  Glu Pro Cys Leu His  Gly Gly Thr 
    4145                 4150                 4155             


Cys Gln  Gly Thr Arg Cys Leu  Cys Leu Pro Gly Phe  Ser Gly Pro 
    4160                 4165                 4170             


Arg Cys  Gln Gln Gly Ser Gly  His Gly Ile Ala Glu  Ser Asp Trp 
    4175                 4180                 4185             


His Leu  Glu Gly Ser Gly Gly  Asn Asp Ala Pro Gly  Gln Tyr Gly 
    4190                 4195                 4200             


Ala Tyr  Phe His Asp Asp Gly  Phe Leu Ala Phe Pro  Gly His Val 
    4205                 4210                 4215             


Phe Ser  Arg Ser Leu Pro Glu  Val Pro Glu Thr Ile  Glu Leu Glu 
    4220                 4225                 4230             


Val Arg  Thr Ser Thr Ala Ser  Gly Leu Leu Leu Trp  Gln Gly Val 
    4235                 4240                 4245             


Glu Val  Gly Glu Ala Gly Gln  Gly Lys Asp Phe Ile  Ser Leu Gly 
    4250                 4255                 4260             


Leu Gln  Asp Gly His Leu Val  Phe Arg Tyr Gln Leu  Gly Ser Gly 
    4265                 4270                 4275             


Glu Ala  Arg Leu Val Ser Glu  Asp Pro Ile Asn Asp  Gly Glu Trp 
    4280                 4285                 4290             


His Arg  Val Thr Ala Leu Arg  Glu Gly Arg Arg Gly  Ser Ile Gln 
    4295                 4300                 4305             


Val Asp  Gly Glu Glu Leu Val  Ser Gly Arg Ser Pro  Gly Pro Asn 
    4310                 4315                 4320             


Val Ala  Val Asn Ala Lys Gly  Ser Val Tyr Ile Gly  Gly Ala Pro 
    4325                 4330                 4335             


Asp Val  Ala Thr Leu Thr Gly  Gly Arg Phe Ser Ser  Gly Ile Thr 
    4340                 4345                 4350             


Gly Cys  Val Lys Asn Leu Val  Leu His Ser Ala Arg  Pro Gly Ala 
    4355                 4360                 4365             


Pro Pro  Pro Gln Pro Leu Asp  Leu Gln His Arg Ala  Gln Ala Gly 
    4370                 4375                 4380             


Ala Asn  Thr Arg Pro Cys Pro  Ser 
    4385                 4390     


<210>  2
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  2

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


