                         SEQUENCE LISTING

<110>  Emory University
       Children's Healthcare of Atlanta, Inc.
 
<120>  Galectin-9 Specific Binding Agents for Use in Treating Cancer

<130>  18091 PCT

<150>  US 63/055,662
<151>  2020-07-23

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  181
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  1

Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg Ile Gly 
            180     


<210>  2
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  2

Gly Tyr Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  3

Phe Tyr Pro Gly Ser His Ser Ile 
1               5               


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  4

His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   


<210>  5
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  5

Gln Ser Leu Phe Tyr Ser Thr Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  6
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  6

Trp Ala Ser Thr 
1               


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  7

Gln Gln Tyr Tyr Tyr Phe Pro Tyr Thr 
1               5                   


<210>  8
<211>  148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  8

Met Lys Cys Ser Trp Gly Ile Phe Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Asn 
65                  70                  75                  80  


Glu Gln Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu 
145             


<210>  9
<211>  153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  9

Leu Asp Gly Gly Lys Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Trp Val Ser Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser 
            20                  25                  30          


Pro Ser Ser Leu Ala Val Ser Val Gly Glu Lys Ile Thr Met Ser Cys 
        35                  40                  45              


Lys Ser Ser Gln Ser Leu Phe Tyr Ser Thr Asn Gln Lys Asn Tyr Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu 
            100                 105                 110         


Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Phe Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    130                 135                 140                 


Thr Val Ser Ile Phe Pro Pro Ser Ser 
145                 150             


<210>  10
<211>  316
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  10

Met Lys Cys Ser Trp Gly Ile Phe Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Asn 
65                  70                  75                  80  


Glu Gln Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Leu Asp Gly Gly Lys Met Asp Ser Gln Ala Gln Val Leu 
                165                 170                 175     


Met Leu Leu Leu Leu Trp Val Ser Gly Thr Cys Gly Asp Ile Val Met 
            180                 185                 190         


Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly Glu Lys Ile Thr 
        195                 200                 205             


Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser Thr Asn Gln Lys 
    210                 215                 220                 


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
225                 230                 235                 240 


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
                245                 250                 255     


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
            260                 265                 270         


Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Phe 
        275                 280                 285             


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
    290                 295                 300                 


Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
305                 310                 315     


<210>  11
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  11

Gly Tyr Thr Phe Thr Glu Tyr Thr 
1               5               


<210>  12
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  12

Phe Tyr Pro Gly Ser Gly Ser 
1               5           


<210>  13
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  13

Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  14

Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  15
<211>  175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  15

Met Gly Trp Ser Phe Ile Ile Leu Leu Ser Val Thr Ala Gly Val His 
1               5                   10                  15      


Ser Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly 
            20                  25                  30          


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu 
        35                  40                  45              


Tyr Thr Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Ile Gly Trp Phe Tyr Pro Gly Ser Gly Ser Met Glu Tyr Asn Glu Lys 
65                  70                  75                  80  


Phe Asp Lys Ala Thr Leu Thr Ala Asp Asn Ser Ser Ser Thr Val Tyr 
                85                  90                  95      


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Glu Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ile Phe Leu Glu Asp Leu Leu Gln Tyr Ser Gln Leu Pro Trp Lys 
145                 150                 155                 160 


Ile Asp Val Leu Leu Leu Phe Ser Gln Asp Phe Gln Ala Val Tyr 
                165                 170                 175 


<210>  16
<211>  153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  16

Leu Asp Gly Gly Lys Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Trp Val Ser Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser 
            20                  25                  30          


Pro Ser Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys 
        35                  40                  45              


Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Trp Ala Ser Thr Arg Gly Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu 
            100                 105                 110         


Asp Leu Ala Ile Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
    130                 135                 140                 


Thr Val Ser Ile Phe Pro Pro Ser Ser 
145                 150             


<210>  17
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  17

Met Gly Trp Ser Phe Ile Ile Leu Leu Ser Val Thr Ala Gly Val His 
1               5                   10                  15      


Ser Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly 
            20                  25                  30          


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu 
        35                  40                  45              


Tyr Thr Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Ile Gly Trp Phe Tyr Pro Gly Ser Gly Ser Met Glu Tyr Asn Glu Lys 
65                  70                  75                  80  


Phe Asp Lys Ala Thr Leu Thr Ala Asp Asn Ser Ser Ser Thr Val Tyr 
                85                  90                  95      


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Glu Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ile Phe Leu Glu Asp Leu Leu Gln Tyr Ser Gln Leu Pro Trp Lys 
145                 150                 155                 160 


Ile Asp Val Leu Leu Leu Phe Ser Gln Asp Phe Gln Ala Val Tyr Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Asp 
            180                 185                 190         


Gly Gly Lys Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu 
        195                 200                 205             


Trp Val Ser Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser 
    210                 215                 220                 


Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
225                 230                 235                 240 


Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu Ala Trp 
                245                 250                 255     


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
            260                 265                 270         


Ser Thr Arg Gly Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        275                 280                 285             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu 
    290                 295                 300                 


Ala Ile Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly 
305                 310                 315                 320 


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val 
                325                 330                 335     


Ser Ile Phe Pro Pro Ser Ser 
            340             


<210>  18
<211>  543
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  18
tccgaagtag aataccgggc tgaggtaggt caaaatgcgt acttgccatg cttctatacc       60

ccggcagcac cgggaaacct tgtgccagtg tgctggggta aaggagcttg ccccgttttt      120

gagtgtggca atgtagtgtt gcgcaccgat gaacgagatg ttaattattg gaccagccgg      180

tattggctta atggtgactt taggaaaggc gatgtctccc tcactatcga gaatgtgaca      240

ttggccgaca gcggaatcta ttgctgtcga attcaaatac ccggtatcat gaatgacgag      300

aagttcaatc ttaaattggt tatcaaacca gccaaggtga ctccggcacc cactaggcaa      360

cgagacttta cggcagcatt cccccggatg ctcacgactc gcggtcacgg acctgccgaa      420

acacagactc ttggttctct tcctgacatt aacctgaccc agatttccac acttgccaac      480

gagctccgcg actccagact cgctaatgac ctgcgcgatt caggagctac tataagaatc      540

ggt                                                                    543


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  948
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  20
atgaagtgta gctgggggat cttttttctt ctcagtgtca ctgcaggagt gcattcaaaa       60

gtccaacttc agcaatcagg agcagaactg gtaaaaccgg gcgcctcagt taaactcagt      120

tgcaaagcta gtgggtacac cttcacagat tatacgattc actgggtaaa gcagaggagt      180

ggacaaggtt tggagtggat cggctggttt tatcccggaa gtcactcaat taaatacaac      240

gaacagttca aggatagagc tacgttgacc gctgacaaat cctcttcaac ggtatatatg      300

gagctttcaa ggcttacatc cgaagattca gcagtctatt tttgcaccag gcacggtggt      360

tacgacggat tcgattattg gggccaggga actactctga cagtgtcatc tgcgaaaaca      420

actccaccga gtgtttatcc tcttggcggc ggagggagtg gtggtggcgg atctggggga      480

ggtggatccc tcgacggcgg aaaaatggat tcacaggcgc aagtcttgat gttgttgttg      540

ctgtgggtat ccggcacctg tggcgacatc gtcatgtccc agtctccttc ctctcttgca      600

gtttcagtag gggaaaaaat aacaatgtcc tgtaaaagta gtcagtccct cttctacagt      660

acaaaccaga aaaactatct ggcatggtat cagcaaaaac cgggccagtc acccaaactg      720

ttgatctatt gggcttctac aagggagagc ggtgtgcccg acaggttcac tggctctggt      780

agtggcacag attttacgct gacgatatca tctgtcaagg ctgaggacct cgcggtctat      840

tactgtcagc aatactacta ttttccatat acttttggtg gtggaacaaa actggagatt      900

aagcgggctg atgcagcacc aacggttagt atatttccac cgtctagt                   948


<210>  21
<211>  1029
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  21
atgggttggt catttattat tcttctctca gtaacagcgg gagtccactc caaggtacag       60

ctgcaacagt ctggcgcgga gctcgtaaaa ccaggggctt ctgtgaagtt gtcttgtaaa      120

gcgtcagggt atactttcac cgaatacacg atccactggg tgaagcagag gagcgggcaa      180

ggcctggagt ggatcggctg gttctacccc gggtcagggt ccatggagta caatgaaaaa      240

tttgataaag cgactctcac agccgacaat agttccagca cggtctatat ggaactttct      300

cggttgacat ccgaggactc agccgtatat ttttgtgagc gccacggagg atacgatggg      360

tttgattatt ggggacaggg gactacgctc acggtgagtt ccgctaagac tactccacct      420

agtgtgtacc cactgatctt cctcgaagac ctcttgcagt actcacaact tccgtggaaa      480

attgacgtgt tgcttttgtt tagccaggac tttcaagctg tctatggggg aggcggaagc      540

ggaggaggtg gtagtggagg cggggggtca ctggatgggg gtaaaatgga ttcacaagct      600

caggtactta tgctccttct gttgtgggtg tccgggactt gtggggacat cgtcatgtca      660

caaagcccat ctagtctggc cgtttcagta ggggaaaagg tgactatgtc ttgcaaaagc      720

agccaaagct tgctctatag taataaccaa aagaattacc tcgcatggta ccagcaaaag      780

ccagggcaat ctcctaaact gttgatctac tgggcttcaa ctcggggtag tggtgtgccc      840

gaccggttca cgggaagcgg gagcggaaca gatttcaccc tcacaatttc atctgtgaaa      900

gctgaggacc ttgccatcta ttactgtcaa cagtactact catatccctt cacgttcggc      960

ggtggcacaa agctcgaaat caagagagcg gacgctgcac ctactgtaag catttttcct     1020

ccctcttcc                                                             1029


<210>  22
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  22
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

ggcgcgcct                                                               69


<210>  23
<211>  759
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  23
gctagcacca ctaccccggc ccctaggccc cctactccag cgccaactat agcatcacag       60

cctttgagct tgaggcccga agcttgcaga ccggcggcag ggggggctgt gcatacaagg      120

ggcctcgact ttgcctgcga catcgataat gagaagagca atggaaccat tatccatgtg      180

aaagggaaac acctttgtcc aagtccccta tttcccggac cttctaagcc cttttgggtg      240

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt      300

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact      360

cccaggaggc ctgggccaac ccgcaagcat taccagccct atgccccacc acgcgacttc      420

gcagcctatc gctccagcag gagcgcagac gctcccgcgt accagcaggg ccagaaccag      480

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      540

ggccgggacc ctgagatggg aggcaagccg agaaggaaga accctcagga aggcctgtac      600

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      660

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      720

acctacgacg cccttcacat gcaggccctg cctcctcgc                             759


<210>  24
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  24

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ala Pro 
            20              


<210>  25
<211>  253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  25

Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
    50                  55                  60                  


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
65                  70                  75                  80  


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                85                  90                  95      


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            100                 105                 110         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        115                 120                 125             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    130                 135                 140                 


Ser Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
145                 150                 155                 160 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                165                 170                 175     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            180                 185                 190         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        195                 200                 205             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    210                 215                 220                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
225                 230                 235                 240 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                245                 250             


<210>  26
<211>  144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  26

Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn Gly Arg Tyr 
1               5                   10                  15      


Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser 
            20                  25                  30          


Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly Phe 
        35                  40                  45              


Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg 
    50                  55                  60                  


Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile 
65                  70                  75                  80  


Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser 
                85                  90                  95      


Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala 
            100                 105                 110         


Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg 
        115                 120                 125             


Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro 
    130                 135                 140                 


<210>  27
<211>  173
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  27

Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu Ile Asn Ser Gln 
1               5                   10                  15      


Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val Ser Asp Cys Thr 
            20                  25                  30          


Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu Ser Glu Phe Leu 
        35                  40                  45              


Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His Lys Tyr Cys Asp 
    50                  55                  60                  


Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr Ser Glu Thr Asp 
65                  70                  75                  80  


Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr Ser Glu Ala Cys 
                85                  90                  95      


Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly Phe Gly Val Lys 
            100                 105                 110         


Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu Pro Cys Pro Val 
        115                 120                 125             


Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys Cys His Pro Trp 
    130                 135                 140                 


Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln Ala Gly Thr Asn 
145                 150                 155                 160 


Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu Arg 
                165                 170             


<210>  28
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  28

Thr Met Ala Ile Trp Arg Ser Asn Ser Gly Ser Asn Thr Leu Glu Asn 
1               5                   10                  15      


Gly Tyr Phe Leu Ser Arg Asn Lys Glu Asn His Ser Gln Pro Thr Gln 
            20                  25                  30          


Ser Ser Leu Glu Asp Ser Val Thr Pro Thr Lys Ala Val Lys Thr Thr 
        35                  40                  45              


Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr Glu Lys 
    50                  55                  60                  


Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly Ser Lys 
65                  70                  75                  80  


Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp Ser Ser 
                85                  90                  95      


Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln Pro Asp Asn 
            100                 105                 110         


Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Thr Glu Val Pro Trp Leu 
        115                 120                 125             


Trp Glu Asp Gly Ser Thr Phe Ser Ser Asn Leu Phe Gln Ile Arg Thr 
    130                 135                 140                 


Thr Ala Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp Ile His Val 
145                 150                 155                 160 


Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr Ser Ile Cys 
                165                 170                 175     


Glu Lys Lys Phe Ser Met 
            180         


<210>  29
<211>  163
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  29

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  30
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct


<220>
<221>  X
<222>  (1)..(16)
<223>  x is any amino acid

<400>  30

Tyr Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Leu 
1               5                   10                  15      


