                         SEQUENCE LISTING

<110>  Molecular Templates, Inc.
       Poma, Eric
       Waltzman, Roger
       Higgins, Jack
       Williams, Eric
 
<120>  CLINICAL METHODS FOR USE OF HER2 BINDING MOLECULES

<130>  MTEM-015/01WO

<150>  US 63/055,074
<151>  2020-07-22

<160>  224   

<170>  PatentIn version 3.5

<210>  1
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga -like toxin 1 Subunit A (SLT- 1A)

<400>  1

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  2
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin Subunit A (StxA)

<400>  2

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  3
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga-like toxin 2 Subunit A (SLT-2A)

<400>  3

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Leu Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg Ser Val Ser Gln Lys Gln 
                245                 250                 255     


Lys Thr Glu Cys Gln Ile Val Gly Asp Arg Ala Ala Ile Lys Val Asn 
            260                 265                 270         


Asn Val Leu Trp Glu Ala Asn Thr Ile Ala Ala Leu Leu Asn Arg Lys 
        275                 280                 285             


Pro Gln Asp Leu Thr Glu Pro Asn Gln 
    290                 295         


<210>  4
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype c Subunit A (Stx1cA)

<400>  4

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Val Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210>  5
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype d Subunit A (Stx1dA)

<400>  5

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Met Gly Leu Glu Pro Glu Glu Glu Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Arg Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


Tyr Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Ile Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210>  6
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype e Subunit A (Stx1eA)

<400>  6

Gln Asp Phe Thr Val Asp Phe Ser Thr Ala Lys Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ala Ile Arg Ser Ala Ile Gly Thr Pro Leu His Ser Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Arg Gly Leu Asp Pro Glu Glu Glu Arg Phe 
    50                  55                  60                  


Asp Asn Leu Arg Leu Ile Ile Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Ser Asn Ile Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Arg Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Gly Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


Tyr Ser Gly Ser Ser Leu Thr Gln Pro Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Val Ser Gly His Ser Tyr Thr Met 
            180                 185                 190         


Thr Val Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Gly Val Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Thr Ser Arg Val Ser Arg 
                245                 250     


<210>  7
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 1

<400>  7

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  8
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 2

<400>  8

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ala 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  9
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 3

<400>  9

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Ile Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  10
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 4

<400>  10

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Ser Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  11
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 5

<400>  11

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Met Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Ser Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  12
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 6

<400>  12

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Val Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Ser Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  13
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2d Subunit A (Stx2dA) variant 1

<400>  13

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ala 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Ile Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  14
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2d Subunit A (Stx2dA) variant 2

<400>  14

Arg Glu Phe Met Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Glu Glu Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Phe Arg Gly Glu Gly Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  15
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2d Subunit A (Stx2dA) variant 3

<400>  15

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Ile Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Ser Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  16
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2e Subunit A (Stx2eA) variant 1

<400>  16

Gln Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Ala Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Ala Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Ile Ser Val Gly Ile Arg Gly Leu Asp Val Tyr Gln Glu Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Thr Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ala 
                85                  90                  95      


His Ile Ser Leu Pro Gly Val Thr Thr Ile Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Leu Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Ala Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  17
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2e Subunit A (Stx2eA) variant 2

<400>  17

Gln Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Ala Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Ala Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Ile Ser Val Gly Ile Arg Gly Leu Asp Val Tyr Gln Ala His Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ala 
                85                  90                  95      


His Ile Ser Leu Pro Gly Val Thr Thr Ile Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Glu Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  18
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Shiga toxin subtype 2f Subunit A (Stx2fA)

<400>  18

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Pro Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg 
                245                 250 


<210>  19
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLTA-DI-1

<400>  19

Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  20
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLTA-DI-2

<400>  20

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  21
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLTA-DI-3

<400>  21

Arg Glu Phe Thr Leu Asp Phe Ser Thr Ala Arg Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  22
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 114773

<400>  22

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
305                 310                 315                 320 


Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu 
    370                 375                 380                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
385                 390                 395                 400 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
            420                 425                 430         


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
    450                 455                 460                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
465                 470                 475                 480 


Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                485                 490                 495     


Thr Val Ser Ser Ala 
            500     


<210>  23
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 115172

<400>  23

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp 
    290                 295                 300                 


Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn 
305                 310                 315                 320 


Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe 
                325                 330                 335     


Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn 
            340                 345                 350         


Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu 
        355                 360                 365             


Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
                405                 410                 415     


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
            420                 425                 430         


Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
    450                 455                 460                 


Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Pro Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
                485                 490                 495     


Val Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser 
            500                 505                 510         


Gly Thr Lys Leu Glu Ile Lys 
        515                 


<210>  24
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 114778

<400>  24

Met Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
305                 310                 315                 320 


Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu 
    370                 375                 380                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
385                 390                 395                 400 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
            420                 425                 430         


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
    450                 455                 460                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
465                 470                 475                 480 


Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                485                 490                 495     


Thr Val Ser Ser Ala 
            500     


<210>  25
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 114795

<400>  25

Met Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Leu Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Glu Ser Leu Lys Ile 
        275                 280                 285             


Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp 
    290                 295                 300                 


Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr 
305                 310                 315                 320 


Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val 
                325                 330                 335     


Thr Ile Ser Val Asp Lys Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser 
            340                 345                 350         


Ser Leu Lys Pro Ser Asp Ser Ala Val Tyr Phe Cys Ala Arg His Asp 
        355                 360                 365             


Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe 
    370                 375                 380                 


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro 
                405                 410                 415     


Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly 
            420                 425                 430         


Asn Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
        435                 440                 445             


Leu Leu Ile Tyr Gly His Thr Asn Arg Pro Ala Gly Val Pro Asp Arg 
    450                 455                 460                 


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
465                 470                 475                 480 


Phe Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
                485                 490                 495     


Ser Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505                 510         


Ala 
    


<210>  26
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 114791

<400>  26

Met Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp 
    290                 295                 300                 


Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn 
305                 310                 315                 320 


Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe 
                325                 330                 335     


Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn 
            340                 345                 350         


Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu 
        355                 360                 365             


Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser His 
385                 390                 395                 400 


Lys Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys 
                405                 410                 415     


Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr 
    450                 455                 460                 


Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
465                 470                 475                 480 


Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
                485                 490                 495     


Glu Ile Lys 
            


<210>  27
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule SLTA-DI-1::scFv4

<400>  27

Met Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
305                 310                 315                 320 


Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu 
    370                 375                 380                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
385                 390                 395                 400 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn 
            420                 425                 430         


Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe 
        435                 440                 445             


Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
    450                 455                 460                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu 
465                 470                 475                 480 


Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala 
            500 


<210>  28
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 114912

<400>  28

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
305                 310                 315                 320 


Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                405                 410                 415     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            420                 425                 430         


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        435                 440                 445             


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    450                 455                 460                 


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
465                 470                 475                 480 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Leu Val Thr Val Ser Ser 
        515                 520 


<210>  29
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 115111

<400>  29

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp 
    290                 295                 300                 


Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn 
305                 310                 315                 320 


Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe 
                325                 330                 335     


Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn 
            340                 345                 350         


Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu 
        355                 360                 365             


Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
                405                 410                 415     


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
            420                 425                 430         


Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
    450                 455                 460                 


Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Pro Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
                485                 490                 495     


Val Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser 
            500                 505                 510         


Gly Thr Lys Leu Glu Ile Lys 
        515                 


<210>  30
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 115411

<400>  30

Met Arg Glu Phe Thr Leu Asp Phe Ser Thr Ala Arg Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu 
            260                 265                 270         


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn 
305                 310                 315                 320 


Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Val 
                325                 330                 335     


Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Thr Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Trp Glu 
        355                 360                 365             


Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
                405                 410                 415     


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly Asp Arg Val Thr 
            420                 425                 430         


Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Val Tyr Ser Ala Ser 
    450                 455                 460                 


Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
                485                 490                 495     


Thr Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Ala Pro 
            500                 505                 510         


Gly Thr Lys Leu Glu Ile Lys 
        515                 


<210>  31
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 114898

<400>  31

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ala His His Ser 
                245                 250                 255     


Glu Asp Pro Ser Ser Lys Ala Pro Lys Ala Pro Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile Asn Thr Met Gly Trp Tyr 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Leu Ile Ser Ser 
305                 310                 315                 320 


Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
            340                 345                 350         


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys Arg Phe Arg Thr Ala 
        355                 360                 365             


Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser Ala 
385     


<210>  32
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 115195

<400>  32

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp 
    290                 295                 300                 


Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn 
305                 310                 315                 320 


Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe 
                325                 330                 335     


Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn 
            340                 345                 350         


Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu 
        355                 360                 365             


Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
385                 390                 395                 400 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
                405                 410                 415     


Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr 
    450                 455                 460                 


Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
465                 470                 475                 480 


Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
                485                 490                 495     


Glu Ile Lys 
            


<210>  33
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 115194

<400>  33

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp 
    290                 295                 300                 


Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn 
305                 310                 315                 320 


Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe 
                325                 330                 335     


Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn 
            340                 345                 350         


Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu 
        355                 360                 365             


Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
385                 390                 395                 400 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
                405                 410                 415     


Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr 
    450                 455                 460                 


Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
465                 470                 475                 480 


Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
                485                 490                 495     


Glu Ile Lys 
            


<210>  34
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 115645

<400>  34

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Val Gln Leu 
                245                 250                 255     


Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
            260                 265                 270         


Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile Asn Thr Met Gly Trp 
        275                 280                 285             


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Leu Ile Ser 
    290                 295                 300                 


Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
                325                 330                 335     


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys Arg Phe Arg Thr 
            340                 345                 350         


Ala Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        355                 360                 365             


Ser Ser Ala 
    370     


<210>  35
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding molecule 115845

<400>  35

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Gln Val Gln Leu 
                245                 250                 255     


Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Lys Leu 
            260                 265                 270         


Thr Cys Ala Ala Ser Gly Tyr Ile Phe Asn Ser Cys Gly Met Gly Trp 
        275                 280                 285             


Tyr Arg Gln Ser Pro Gly Arg Glu Arg Glu Leu Val Ser Arg Ile Ser 
    290                 295                 300                 


Gly Asp Gly Asp Thr Trp His Lys Glu Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Gln Asp Asn Val Lys Lys Thr Leu Tyr Leu Gln Met Asn Ser 
                325                 330                 335     


Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala Val Cys Tyr Asn 
            340                 345                 350         


Leu Glu Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His 
        355                 360                 365             


His His His His His 
    370             


<210>  36
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLTA-DI-2::scFv8

<400>  36

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp 
    290                 295                 300                 


Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn 
305                 310                 315                 320 


Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe 
                325                 330                 335     


Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn 
            340                 345                 350         


Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu 
        355                 360                 365             


Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
                405                 410                 415     


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
            420                 425                 430         


Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly 
    450                 455                 460                 


Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe 
465                 470                 475                 480 


Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln 
                485                 490                 495     


Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
            500                 505                 510         


Ile Lys 
        


<210>  37
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  STLA-FR

<400>  37

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR1

<400>  45

Asp Thr Tyr Ile His 
1               5   


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR2

<400>  46

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR3

<400>  47

Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR1

<400>  48

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR2

<400>  49

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR3

<400>  50

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR1

<400>  51

Ser Tyr Trp Ile Ala 
1               5   


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR2

<400>  52

Leu Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR3

<400>  53

His Asp Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp Pro Glu 
1               5                   10                  15      


Tyr Phe Gln His 
            20  


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR1

<400>  54

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR2

<400>  55

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR3

<400>  56

Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR1

<400>  57

Asn Tyr Gly Met Asn 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR2

<400>  58

Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR3

<400>  59

Trp Glu Val Tyr His Gly Tyr Val Pro Tyr 
1               5                   10  


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR1

<400>  60

Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala 
1               5                   10      


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR2

<400>  61

Ser Ala Ser Ser Arg Tyr Thr 
1               5           


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR3

<400>  62

Gln Gln His Phe Arg Thr Pro Phe Thr 
1               5                   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR1

<400>  63

Asp Tyr Thr Met Asp 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR2

<400>  64

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR3

<400>  65

Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR1

<400>  66

Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala 
1               5                   10      


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR2

<400>  67

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR3

<400>  68

Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR1

<400>  69

Ile Asn Thr Met Gly 
1               5   


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR2

<400>  70

Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vhCDR3

<400>  71

Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr 
1               5                   10  


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR1

<400>  72

Ser Cys Gly Met Gly 
1               5   


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR2

<400>  73

Arg Leu Ser Gly Asp Gly Asp Thr Trp His Lys Glu Ser Val Lys Gly 
1               5                   10                  15      


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  vlCDR3

<400>  74

Cys Tyr Asn Leu Glu Thr Tyr 
1               5           


<210>  75
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 1

<400>  75

Lys Glu Phe Ile Leu Arg Phe Ser Val Ala His Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  76
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 2

<400>  76

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  77
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 3

<400>  77

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Asn Leu Val Pro Met 
        35                  40                  45              


Val Ala Thr Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  78
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 4

<400>  78

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Leu Gly Phe 
        35                  40                  45              


Val Phe Thr Leu Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  79
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 5

<400>  79

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  80
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 6

<400>  80

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  81
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 7

<400>  81

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  82
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 8

<400>  82

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  83
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 9

<400>  83

Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Ile Glu Ala Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Ala Ala Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  84
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 10

<400>  84

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250         


<210>  85
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 11

<400>  85

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  86
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 12

<400>  86

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr Val 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  87
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 13

<400>  87

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Leu Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  88
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 14

<400>  88

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ile Leu Arg Phe Ser Val Ala His Lys Ala Ser 
                245                 250                 255     


Ala Val Ala Ala 
            260 


<210>  89
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SLT-1A-combo variant 15

<400>  89

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Ala Val Ala Ala 
            260         


<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 1

<400>  97

Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
            420                 425                 430         


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        435                 440                 445             


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
    450                 455                 460                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
465                 470                 475                 480 


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala 
            500 


<210>  98
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 2

<400>  98

Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Leu 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser 
        275                 280                 285             


Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val 
    290                 295                 300                 


Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro 
305                 310                 315                 320 


Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr 
                325                 330                 335     


Ile Ser Val Asp Lys Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser 
            340                 345                 350         


Leu Lys Pro Ser Asp Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val 
        355                 360                 365             


Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln 
    370                 375                 380                 


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly 
                405                 410                 415     


Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn 
            420                 425                 430         


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        435                 440                 445             


Leu Ile Tyr Gly His Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe 
    450                 455                 460                 


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe 
465                 470                 475                 480 


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                485                 490                 495     


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala 
            500                 505                 510         


<210>  99
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 3

<400>  99

Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp Val 
    290                 295                 300                 


Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr 
305                 310                 315                 320 


Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe Asp 
                325                 330                 335     


Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn Asn 
            340                 345                 350         


Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu Val 
        355                 360                 365             


Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser His Lys 
385                 390                 395                 400 


Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
                405                 410                 415     


Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe 
    450                 455                 460                 


Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln 
465                 470                 475                 480 


Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
                485                 490                 495     


Ile Lys 
        


<210>  100
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 4

<400>  100

Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr 
305                 310                 315                 320 


Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro 
            420                 425                 430         


Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr 
        435                 440                 445             


Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    450                 455                 460                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly 
465                 470                 475                 480 


Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser Ala 
            


<210>  101
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 5

<400>  101

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            420                 425                 430         


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        435                 440                 445             


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                485                 490                 495     


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Leu Val Thr Val Ser Ser 
        515                 


<210>  102
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 6

<400>  102

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp Val 
    290                 295                 300                 


Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr 
305                 310                 315                 320 


Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe Asp 
                325                 330                 335     


Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn Asn 
            340                 345                 350         


Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu Val 
        355                 360                 365             


Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                405                 410                 415     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
            420                 425                 430         


Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
    450                 455                 460                 


Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val 
                485                 490                 495     


Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly 
            500                 505                 510         


Thr Lys Leu Glu Ile Lys 
        515             


<210>  103
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 7

<400>  103

Arg Glu Phe Thr Leu Asp Phe Ser Thr Ala Arg Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr 
305                 310                 315                 320 


Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Met Thr Thr Asp Thr Ser Thr Ser Thr Thr Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Arg Pro Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Trp Glu Val 
        355                 360                 365             


Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                405                 410                 415     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile 
            420                 425                 430         


Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Val Tyr Ser Ala Ser Ser 
    450                 455                 460                 


Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
                485                 490                 495     


Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Ala Pro Gly 
            500                 505                 510         


Thr Lys Leu Glu Ile Lys 
        515             


<210>  104
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 8

<400>  104

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ala His His Ser Glu 
                245                 250                 255     


Asp Pro Ser Ser Lys Ala Pro Lys Ala Pro Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Ile Thr Phe Ser Ile Asn Thr Met Gly Trp Tyr Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Leu Ile Ser Ser Ile 
305                 310                 315                 320 


Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys Arg Phe Arg Thr Ala Ala 
        355                 360                 365             


Gln Gly Thr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    370                 375                 380                 


Ala 
385 


<210>  105
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 9

<400>  105

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp Val 
    290                 295                 300                 


Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr 
305                 310                 315                 320 


Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe Asp 
                325                 330                 335     


Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn Asn 
            340                 345                 350         


Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu Val 
        355                 360                 365             


Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
                405                 410                 415     


Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe 
    450                 455                 460                 


Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln 
465                 470                 475                 480 


Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
                485                 490                 495     


Ile Lys 
        


<210>  106
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 10

<400>  106

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Ile Thr Phe Ser Ile Asn Thr Met Gly Trp Tyr 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Leu Ile Ser Ser 
    290                 295                 300                 


Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
                325                 330                 335     


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys Arg Phe Arg Thr Ala 
            340                 345                 350         


Ala Gln Gly Thr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        355                 360                 365             


Ser Ala 
    370 


<210>  107
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 11

<400>  107

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Gln Val Gln Leu Gln 
                245                 250                 255     


Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Lys Leu Thr 
            260                 265                 270         


Cys Ala Ala Ser Gly Tyr Ile Phe Asn Ser Cys Gly Met Gly Trp Tyr 
        275                 280                 285             


Arg Gln Ser Pro Gly Arg Glu Arg Glu Leu Val Ser Arg Ile Ser Gly 
    290                 295                 300                 


Asp Gly Asp Thr Trp His Lys Glu Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Gln Asp Asn Val Lys Lys Thr Leu Tyr Leu Gln Met Asn Ser Leu 
                325                 330                 335     


Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala Val Cys Tyr Asn Leu 
            340                 345                 350         


Glu Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 365     


<210>  108
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2-targeting molecule 12

<400>  108

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp Val 
    290                 295                 300                 


Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr 
305                 310                 315                 320 


Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe Asp 
                325                 330                 335     


Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn Asn 
            340                 345                 350         


Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu Val 
        355                 360                 365             


Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                405                 410                 415     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            420                 425                 430         


Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val 
    450                 455                 460                 


Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr 
465                 470                 475                 480 


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
                485                 490                 495     


His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            500                 505                 510         


Lys 
    


<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
000

<210>  135

<400>  135
000

<210>  136

<400>  136
000

<210>  137

<400>  137
000

<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141

<400>  141
000

<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144

<400>  144
000

<210>  145

<400>  145
000

<210>  146

<400>  146
000

<210>  147

<400>  147
000

<210>  148

<400>  148
000

<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (3)..(4)
<223>  may be absent

<220>
<221>  SITE
<222>  (5)..(6)
<223>  may be absent

<220>
<221>  SITE
<222>  (7)..(8)
<223>  may be absent

<400>  187

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  188
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  SITE
<222>  (11)..(15)
<223>  may be absent

<220>
<221>  SITE
<222>  (16)..(20)
<223>  may be absent

<400>  188

Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser 
            20  


<210>  189
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  SITE
<222>  (11)..(15)
<223>  may be absent

<220>
<221>  SITE
<222>  (16)..(20)
<223>  may be absent

<400>  189

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  190
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (5)..(8)
<223>  may be absent

<220>
<221>  SITE
<222>  (9)..(12)
<223>  may be absent

<220>
<221>  SITE
<222>  (13)..(16)
<223>  may be absent

<400>  190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Motif


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<400>  195

Arg Xaa Xaa Arg 
1               


<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  199

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25          


<210>  200
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  200

Gly Ser Gly Ser Gly 
1               5   


<210>  201
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  201

Ala Ser Gly Gly Pro Glu 
1               5       


<210>  202
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (5)..(6)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (7)..(12)
<223>  May be absent

<220>
<221>  SITE
<222>  (10)..(11)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (13)..(17)
<223>  May be absent

<220>
<221>  SITE
<222>  (15)..(16)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (18)..(22)
<223>  May be absent

<220>
<221>  SITE
<222>  (20)..(21)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (23)..(27)
<223>  May be absent

<220>
<221>  SITE
<222>  (25)..(26)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (28)..(32)
<223>  May be absent

<220>
<221>  SITE
<222>  (30)..(31)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (33)..(37)
<223>  May be absent

<220>
<221>  SITE
<222>  (35)..(36)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (38)..(42)
<223>  May be absent

<220>
<221>  SITE
<222>  (40)..(41)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (43)..(47)
<223>  May be absent

<220>
<221>  SITE
<222>  (45)..(46)
<223>  Up to 2 residues may be absent

<220>
<221>  SITE
<222>  (48)..(52)
<223>  May be absent

<220>
<221>  SITE
<222>  (50)..(51)
<223>  Up to 2 residues may be absent

<400>  202

Ala Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Ala Met 
    50                  


<210>  203
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (2)..(6)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (8)..(14)
<223>  May be absent

<220>
<221>  SITE
<222>  (9)..(13)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (15)..(21)
<223>  May be absent

<220>
<221>  SITE
<222>  (16)..(20)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (22)..(28)
<223>  May be absent

<220>
<221>  SITE
<222>  (23)..(27)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (29)..(35)
<223>  May be absent

<220>
<221>  SITE
<222>  (30)..(34)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (36)..(42)
<223>  May be absent

<220>
<221>  SITE
<222>  (37)..(41)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (42)..(48)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (43)..(49)
<223>  May be absent

<220>
<221>  SITE
<222>  (50)..(56)
<223>  May be absent

<220>
<221>  SITE
<222>  (51)..(55)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (57)..(63)
<223>  May be absent

<220>
<221>  SITE
<222>  (58)..(61)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (64)..(70)
<223>  May be absent

<220>
<221>  SITE
<222>  (65)..(69)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (71)..(77)
<223>  May be absent

<220>
<221>  SITE
<222>  (72)..(76)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (78)..(84)
<223>  May be absent

<220>
<221>  SITE
<222>  (79)..(83)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (85)..(91)
<223>  May be absent

<220>
<221>  SITE
<222>  (86)..(90)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (92)..(98)
<223>  May be absent

<220>
<221>  SITE
<222>  (93)..(97)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (99)..(105)
<223>  May be absent

<220>
<221>  SITE
<222>  (100)..(104)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (106)..(112)
<223>  May be absent

<220>
<221>  SITE
<222>  (107)..(111)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (113)..(119)
<223>  May be absent

<220>
<221>  SITE
<222>  (114)..(118)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (120)..(126)
<223>  May be absent

<220>
<221>  SITE
<222>  (121)..(125)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (127)..(133)
<223>  May be absent

<220>
<221>  SITE
<222>  (128)..(132)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (134)..(140)
<223>  May be absent

<220>
<221>  SITE
<222>  (135)..(139)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (141)..(147)
<223>  May be absent

<220>
<221>  SITE
<222>  (142)..(146)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (148)..(154)
<223>  May be absent

<220>
<221>  SITE
<222>  (149)..(153)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (155)..(161)
<223>  May be absent

<220>
<221>  SITE
<222>  (156)..(160)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (162)..(168)
<223>  May be absent

<220>
<221>  SITE
<222>  (163)..(167)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (169)..(175)
<223>  May be absent

<220>
<221>  SITE
<222>  (170)..(174)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (176)..(182)
<223>  May be absent

<220>
<221>  SITE
<222>  (177)..(181)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (183)..(189)
<223>  May be absent

<220>
<221>  SITE
<222>  (184)..(188)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (190)..(196)
<223>  May be absent

<220>
<221>  SITE
<222>  (191)..(195)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (197)..(203)
<223>  May be absent

<220>
<221>  SITE
<222>  (198)..(202)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (204)..(210)
<223>  May be absent

<220>
<221>  SITE
<222>  (205)..(209)
<223>  Up to 5 residues may be absent

<400>  203

Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Ser 
    210 


<210>  204
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (2)..(6)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (8)..(14)
<223>  May be absent

<220>
<221>  SITE
<222>  (9)..(13)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (15)..(21)
<223>  May be absent

<220>
<221>  SITE
<222>  (16)..(20)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (22)..(28)
<223>  May be absent

<220>
<221>  SITE
<222>  (23)..(27)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (29)..(35)
<223>  May be absent

<220>
<221>  SITE
<222>  (30)..(34)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (36)..(42)
<223>  May be absent

<220>
<221>  SITE
<222>  (37)..(41)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (42)..(48)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (43)..(49)
<223>  May be absent

<220>
<221>  SITE
<222>  (50)..(56)
<223>  May be absent

<220>
<221>  SITE
<222>  (51)..(55)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (57)..(63)
<223>  May be absent

<220>
<221>  SITE
<222>  (58)..(61)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (64)..(70)
<223>  May be absent

<220>
<221>  SITE
<222>  (65)..(69)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (71)..(77)
<223>  May be absent

<220>
<221>  SITE
<222>  (72)..(76)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (78)..(84)
<223>  May be absent

<220>
<221>  SITE
<222>  (79)..(83)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (85)..(91)
<223>  May be absent

<220>
<221>  SITE
<222>  (86)..(90)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (92)..(98)
<223>  May be absent

<220>
<221>  SITE
<222>  (93)..(97)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (99)..(105)
<223>  May be absent

<220>
<221>  SITE
<222>  (100)..(104)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (106)..(112)
<223>  May be absent

<220>
<221>  SITE
<222>  (107)..(111)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (113)..(119)
<223>  May be absent

<220>
<221>  SITE
<222>  (114)..(118)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (120)..(126)
<223>  May be absent

<220>
<221>  SITE
<222>  (121)..(125)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (127)..(133)
<223>  May be absent

<220>
<221>  SITE
<222>  (128)..(132)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (134)..(140)
<223>  May be absent

<220>
<221>  SITE
<222>  (135)..(139)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (141)..(147)
<223>  May be absent

<220>
<221>  SITE
<222>  (142)..(146)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (148)..(154)
<223>  May be absent

<220>
<221>  SITE
<222>  (149)..(153)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (155)..(161)
<223>  May be absent

<220>
<221>  SITE
<222>  (156)..(160)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (162)..(168)
<223>  May be absent

<220>
<221>  SITE
<222>  (163)..(167)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (169)..(175)
<223>  May be absent

<220>
<221>  SITE
<222>  (170)..(174)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (176)..(182)
<223>  May be absent

<220>
<221>  SITE
<222>  (177)..(181)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (183)..(189)
<223>  May be absent

<220>
<221>  SITE
<222>  (184)..(188)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (190)..(196)
<223>  May be absent

<220>
<221>  SITE
<222>  (191)..(195)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (197)..(203)
<223>  May be absent

<220>
<221>  SITE
<222>  (198)..(202)
<223>  Up to 5 residues may be absent

<220>
<221>  SITE
<222>  (204)..(210)
<223>  May be absent

<220>
<221>  SITE
<222>  (205)..(209)
<223>  Up to 5 residues may be absent

<400>  204

Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
    50                  55                  60                  


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly 
            100                 105                 110         


Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser 
        115                 120                 125             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
                165                 170                 175     


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Gly 
    210 


<210>  205
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (6)..(10)
<223>  May be absent

<220>
<221>  SITE
<222>  (11)..(15)
<223>  May be absent

<220>
<221>  SITE
<222>  (16)..(20)
<223>  May be absent

<220>
<221>  SITE
<222>  (21)..(25)
<223>  May be absent

<220>
<221>  SITE
<222>  (26)..(30)
<223>  May be absent

<220>
<221>  SITE
<222>  (31)..(35)
<223>  May be absent

<220>
<221>  SITE
<222>  (36)..(40)
<223>  May be absent

<220>
<221>  SITE
<222>  (41)..(45)
<223>  May be absent

<220>
<221>  SITE
<222>  (46)..(50)
<223>  May be absent

<220>
<221>  SITE
<222>  (51)..(55)
<223>  May be absent

<220>
<221>  SITE
<222>  (56)..(60)
<223>  May be absent

<220>
<221>  SITE
<222>  (61)..(65)
<223>  May be absent

<220>
<221>  SITE
<222>  (66)..(70)
<223>  May be absent

<220>
<221>  SITE
<222>  (71)..(75)
<223>  May be absent

<220>
<221>  SITE
<222>  (76)..(80)
<223>  May be absent

<220>
<221>  SITE
<222>  (81)..(85)
<223>  May be absent

<220>
<221>  SITE
<222>  (86)..(90)
<223>  May be absent

<220>
<221>  SITE
<222>  (91)..(95)
<223>  May be absent

<220>
<221>  SITE
<222>  (96)..(100)
<223>  May be absent

<220>
<221>  SITE
<222>  (101)..(105)
<223>  May be absent

<220>
<221>  SITE
<222>  (106)..(110)
<223>  May be absent

<220>
<221>  SITE
<222>  (111)..(115)
<223>  May be absent

<220>
<221>  SITE
<222>  (116)..(120)
<223>  May be absent

<220>
<221>  SITE
<222>  (121)..(125)
<223>  May be absent

<220>
<221>  SITE
<222>  (126)..(130)
<223>  May be absent

<220>
<221>  SITE
<222>  (131)..(135)
<223>  May be absent

<220>
<221>  SITE
<222>  (136)..(140)
<223>  May be absent

<220>
<221>  SITE
<222>  (141)..(145)
<223>  May be absent

<220>
<221>  SITE
<222>  (146)..(150)
<223>  May be absent

<400>  205

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210>  206
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  SITE
<222>  (2)..(30)
<223>  Up to 29 may be absent

<400>  206

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30  


<210>  207
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  207

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  208
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  208

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210>  209
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  209

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  210
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  210

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  211
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  211

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  212
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  212

Ser Arg Ser Ser Gly 
1               5   


<210>  213
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  213

Ser Gly Ser Ser Cys 
1               5   


<210>  214
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 1

<400>  214

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  215
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 2

<400>  215

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  216
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 3

<400>  216

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  217
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 4

<400>  217

Gly Gly Gly Gly Ser 
1               5   


<210>  218
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 5

<400>  218

Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro 
1               5                   10                  15      


<210>  219
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 6

<400>  219

Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro 
1               5                   10                  15      


Gly Ile Leu Gly Phe Val Phe Thr Leu 
            20                  25  


<210>  220
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 7

<400>  220

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
1               5                   10                  15  


<210>  221
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 8

<400>  221

Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser 
1               5                   10                  15      


<210>  222
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker 9

<400>  222

Ala His His Ser Glu Asp Pro Ser Ser Lys Ala Pro Lys Ala Pro 
1               5                   10                  15  


<210>  223
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Protease

<400>  223

Ala Met Gly Arg Ser Gly Gly Gly Cys Ala Gly Asn Arg Val Gly Ser 
1               5                   10                  15      


Ser Leu Ser Cys Gly Gly Leu Asn Leu Gln Ala Met 
            20                  25              


<210>  224
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HER2 binding region

<400>  224

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala 
                165                 170                 175     


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr Gly 
        195                 200                 205             


Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
    210                 215                 220                 


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe 
225                 230                 235                 240 


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
                245                 250     


