                         SEQUENCE LISTING

<110>  Firmenich Incorporated
 
<120>  Savory Taste Enhancement via Transmembrane Region Binding

<130>  13780/SNMX/WO

<150>  63/056,389
<151>  2020-07-24

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  841
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Cys Thr Ala Arg Leu Val Gly Leu Gln Leu Leu Ile Ser 
1               5                   10                  15      


Cys Cys Trp Ala Phe Ala Cys His Ser Thr Glu Ser Ser Pro Asp Phe 
            20                  25                  30          


Thr Leu Pro Gly Asp Tyr Leu Leu Ala Gly Leu Phe Pro Leu His Ser 
        35                  40                  45              


Gly Cys Leu Gln Val Arg His Arg Pro Glu Val Thr Leu Cys Asp Arg 
    50                  55                  60                  


Ser Cys Ser Phe Asn Glu His Gly Tyr His Leu Phe Gln Ala Met Arg 
65                  70                  75                  80  


Leu Gly Val Glu Glu Ile Asn Asn Ser Thr Ala Leu Leu Pro Asn Ile 
                85                  90                  95      


Thr Leu Gly Tyr Gln Leu Tyr Asp Val Cys Ser Asp Ser Ala Asn Val 
            100                 105                 110         


Tyr Ala Thr Leu Arg Val Leu Ser Leu Pro Gly Gln His His Ile Glu 
        115                 120                 125             


Leu Gln Gly Asp Leu Leu His Tyr Ser Pro Thr Val Leu Ala Val Ile 
    130                 135                 140                 


Gly Pro Asp Ser Thr Asn Arg Ala Ala Thr Thr Ala Ala Leu Leu Ser 
145                 150                 155                 160 


Pro Phe Leu Val Pro Met Ile Ser Tyr Ala Ala Ser Ser Glu Thr Leu 
                165                 170                 175     


Ser Val Lys Arg Gln Tyr Pro Ser Phe Leu Arg Thr Ile Pro Asn Asp 
            180                 185                 190         


Lys Tyr Gln Val Glu Thr Met Val Leu Leu Leu Gln Lys Phe Gly Trp 
        195                 200                 205             


Thr Trp Ile Ser Leu Val Gly Ser Ser Asp Asp Tyr Gly Gln Leu Gly 
    210                 215                 220                 


Val Gln Ala Leu Glu Asn Gln Ala Thr Gly Gln Gly Ile Cys Ile Ala 
225                 230                 235                 240 


Phe Lys Asp Ile Met Pro Phe Ser Ala Gln Val Gly Asp Glu Arg Met 
                245                 250                 255     


Gln Cys Leu Met Arg His Leu Ala Gln Ala Gly Ala Thr Val Val Val 
            260                 265                 270         


Val Phe Ser Ser Arg Gln Leu Ala Arg Val Phe Phe Glu Ser Val Val 
        275                 280                 285             


Leu Thr Asn Leu Thr Gly Lys Val Trp Val Ala Ser Glu Ala Trp Ala 
    290                 295                 300                 


Leu Ser Arg His Ile Thr Gly Val Pro Gly Ile Gln Arg Ile Gly Met 
305                 310                 315                 320 


Val Leu Gly Val Ala Ile Gln Lys Arg Ala Val Pro Gly Leu Lys Ala 
                325                 330                 335     


Phe Glu Glu Ala Tyr Ala Arg Ala Asp Lys Lys Ala Pro Arg Pro Cys 
            340                 345                 350         


His Lys Gly Ser Trp Cys Ser Ser Asn Gln Leu Cys Arg Glu Cys Gln 
        355                 360                 365             


Ala Phe Met Ala His Thr Met Pro Lys Leu Lys Ala Phe Ser Met Ser 
    370                 375                 380                 


Ser Ala Tyr Asn Ala Tyr Arg Ala Val Tyr Ala Val Ala His Gly Leu 
385                 390                 395                 400 


His Gln Leu Leu Gly Cys Ala Ser Gly Ala Cys Ser Arg Gly Arg Val 
                405                 410                 415     


Tyr Pro Trp Gln Leu Leu Glu Gln Ile His Lys Val His Phe Leu Leu 
            420                 425                 430         


His Lys Asp Thr Val Ala Phe Asn Asp Asn Arg Asp Pro Leu Ser Ser 
        435                 440                 445             


Tyr Asn Ile Ile Ala Trp Asp Trp Asn Gly Pro Lys Trp Thr Phe Thr 
    450                 455                 460                 


Val Leu Gly Ser Ser Thr Trp Ser Pro Val Gln Leu Asn Ile Asn Glu 
465                 470                 475                 480 


Thr Lys Ile Gln Trp His Gly Lys Asp Asn Gln Val Pro Lys Ser Val 
                485                 490                 495     


Cys Ser Ser Asp Cys Leu Glu Gly His Gln Arg Val Val Thr Gly Phe 
            500                 505                 510         


His His Cys Cys Phe Glu Cys Val Pro Cys Gly Ala Gly Thr Phe Leu 
        515                 520                 525             


Asn Lys Ser Asp Leu Tyr Arg Cys Gln Pro Cys Gly Lys Glu Glu Trp 
    530                 535                 540                 


Ala Pro Glu Gly Ser Gln Thr Cys Phe Pro Arg Thr Val Val Phe Leu 
545                 550                 555                 560 


Ala Leu Arg Glu His Thr Ser Trp Val Leu Leu Ala Ala Asn Thr Leu 
                565                 570                 575     


Leu Leu Leu Leu Leu Leu Gly Thr Ala Gly Leu Phe Ala Trp His Leu 
            580                 585                 590         


Asp Thr Pro Val Val Arg Ser Ala Gly Gly Arg Leu Cys Phe Leu Met 
        595                 600                 605             


Leu Gly Ser Leu Ala Ala Gly Ser Gly Ser Leu Tyr Gly Phe Phe Gly 
    610                 615                 620                 


Glu Pro Thr Arg Pro Ala Cys Leu Leu Arg Gln Ala Leu Phe Ala Leu 
625                 630                 635                 640 


Gly Phe Thr Ile Phe Leu Ser Cys Leu Thr Val Arg Ser Phe Gln Leu 
                645                 650                 655     


Ile Ile Ile Phe Lys Phe Ser Thr Lys Val Pro Thr Phe Tyr His Ala 
            660                 665                 670         


Trp Val Gln Asn His Gly Ala Gly Leu Phe Val Met Ile Ser Ser Ala 
        675                 680                 685             


Ala Gln Leu Leu Ile Cys Leu Thr Trp Leu Val Val Trp Thr Pro Leu 
    690                 695                 700                 


Pro Ala Arg Glu Tyr Gln Arg Phe Pro His Leu Val Met Leu Glu Cys 
705                 710                 715                 720 


Thr Glu Thr Asn Ser Leu Gly Phe Ile Leu Ala Phe Leu Tyr Asn Gly 
                725                 730                 735     


Leu Leu Ser Ile Ser Ala Phe Ala Cys Ser Tyr Leu Gly Lys Asp Leu 
            740                 745                 750         


Pro Glu Asn Tyr Asn Glu Ala Lys Cys Val Thr Phe Ser Leu Leu Phe 
        755                 760                 765             


Asn Phe Val Ser Trp Ile Ala Phe Phe Thr Thr Ala Ser Val Tyr Asp 
    770                 775                 780                 


Gly Lys Tyr Leu Pro Ala Ala Asn Met Met Ala Gly Leu Ser Ser Leu 
785                 790                 795                 800 


Ser Ser Gly Phe Gly Gly Tyr Phe Leu Pro Lys Cys Tyr Val Ile Leu 
                805                 810                 815     


Cys Arg Pro Asp Leu Asn Ser Thr Glu His Phe Gln Ala Ser Ile Gln 
            820                 825                 830         


Asp Tyr Thr Arg Arg Cys Gly Ser Thr 
        835                 840     


<210>  2
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence containing transmembrane domain region of T1R1 taste 
       receptor

<400>  2

Met Leu Leu Cys Thr Ala Arg Leu Val Gly Leu Gln Leu Leu Ile Ser 
1               5                   10                  15      


Cys Cys Trp Ala Phe Ala Cys His Ser Thr Glu Ser Ser Pro Asp Phe 
            20                  25                  30          


Thr Leu Pro Gly Asp Tyr Leu Leu Ala Gly Leu Phe Pro Phe Pro Arg 
        35                  40                  45              


Thr Val Val Phe Leu Ala Leu Arg Glu His Thr Ser Trp Val Leu Leu 
    50                  55                  60                  


Ala Ala Asn Thr Leu Leu Leu Leu Leu Leu Leu Gly Thr Ala Gly Leu 
65                  70                  75                  80  


Phe Ala Trp His Leu Asp Thr Pro Val Val Arg Ser Ala Gly Gly Arg 
                85                  90                  95      


Leu Cys Phe Leu Met Leu Gly Ser Leu Ala Ala Gly Ser Gly Ser Leu 
            100                 105                 110         


Tyr Gly Phe Phe Gly Glu Pro Thr Arg Pro Ala Cys Leu Leu Arg Gln 
        115                 120                 125             


Ala Leu Phe Ala Leu Gly Phe Thr Ile Phe Leu Ser Cys Leu Thr Val 
    130                 135                 140                 


Arg Ser Phe Gln Leu Ile Ile Ile Phe Lys Phe Ser Thr Lys Val Pro 
145                 150                 155                 160 


Thr Phe Tyr His Ala Trp Val Gln Asn His Gly Ala Gly Leu Phe Val 
                165                 170                 175     


Met Ile Ser Ser Ala Ala Gln Leu Leu Ile Cys Leu Thr Trp Leu Val 
            180                 185                 190         


Val Trp Thr Pro Leu Pro Ala Arg Glu Tyr Gln Arg Phe Pro His Leu 
        195                 200                 205             


Val Met Leu Glu Cys Thr Glu Thr Asn Ser Leu Gly Phe Ile Leu Ala 
    210                 215                 220                 


Phe Leu Tyr Asn Gly Leu Leu Ser Ile Ser Ala Phe Ala Cys Ser Tyr 
225                 230                 235                 240 


Leu Gly Lys Asp Leu Pro Glu Asn Tyr Asn Glu Ala Lys Cys Val Thr 
                245                 250                 255     


Phe Ser Leu Leu Phe Asn Phe Val Ser Trp Ile Ala Phe Phe Thr Thr 
            260                 265                 270         


Ala Ser Val Tyr Asp Gly Lys Tyr Leu Pro Ala Ala Asn Met Met Ala 
        275                 280                 285             


Gly Leu Ser Ser Leu Ser Ser Gly Phe Gly Gly Tyr Phe Leu Pro Lys 
    290                 295                 300                 


Cys Tyr Val Ile Leu Cys Arg Pro Asp Leu Asn Ser Thr Glu His Phe 
305                 310                 315                 320 


Gln Ala Ser Ile Gln Asp Tyr Thr Arg Arg Cys Gly Ser Thr Glu Gln 
                325                 330                 335     


Lys Leu Ile Ser Glu Glu Asp Leu 
            340                 


<210>  3
<211>  856
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of chimeric T1R3 taste receptor containing Homo sapiens 
       transmembrane domain region and Rattus norvegicus venus flytrap 
       domain region

<400>  3

Met Pro Gly Leu Ala Ile Leu Gly Leu Ser Leu Ala Ala Phe Leu Glu 
1               5                   10                  15      


Leu Gly Met Gly Ser Ser Leu Cys Leu Ser Gln Gln Phe Lys Ala Gln 
            20                  25                  30          


Gly Asp Tyr Ile Leu Gly Gly Leu Phe Pro Leu Gly Thr Thr Glu Glu 
        35                  40                  45              


Ala Thr Leu Asn Gln Arg Thr Gln Pro Asn Gly Ile Leu Cys Thr Arg 
    50                  55                  60                  


Phe Ser Pro Leu Gly Leu Phe Leu Ala Met Ala Met Lys Met Ala Val 
65                  70                  75                  80  


Glu Glu Ile Asn Asn Gly Ser Ala Leu Leu Pro Gly Leu Arg Leu Gly 
                85                  90                  95      


Tyr Asp Leu Phe Asp Thr Cys Ser Glu Pro Val Val Thr Met Lys Pro 
            100                 105                 110         


Ser Leu Met Phe Met Ala Lys Val Gly Ser Gln Ser Ile Ala Ala Tyr 
        115                 120                 125             


Cys Asn Tyr Thr Gln Tyr Gln Pro Arg Val Leu Ala Val Ile Gly Pro 
    130                 135                 140                 


His Ser Ser Glu Leu Ala Leu Ile Thr Gly Lys Phe Phe Ser Phe Phe 
145                 150                 155                 160 


Leu Met Pro Gln Val Ser Tyr Ser Ala Ser Met Asp Arg Leu Ser Asp 
                165                 170                 175     


Arg Glu Thr Phe Pro Ser Phe Phe Arg Thr Val Pro Ser Asp Arg Val 
            180                 185                 190         


Gln Leu Gln Ala Val Val Thr Leu Leu Gln Asn Phe Ser Trp Asn Trp 
        195                 200                 205             


Val Ala Ala Leu Gly Ser Asp Asp Asp Tyr Gly Arg Glu Gly Leu Ser 
    210                 215                 220                 


Ile Phe Ser Gly Leu Ala Asn Ser Arg Gly Ile Cys Ile Ala His Glu 
225                 230                 235                 240 


Gly Leu Val Pro Gln His Asp Thr Ser Gly Gln Gln Leu Gly Lys Val 
                245                 250                 255     


Val Asp Val Leu Arg Gln Val Asn Gln Ser Lys Val Gln Val Val Val 
            260                 265                 270         


Leu Phe Ala Ser Ala Arg Ala Val Tyr Ser Leu Phe Ser Tyr Ser Ile 
        275                 280                 285             


Leu His Asp Leu Ser Pro Lys Val Trp Val Ala Ser Glu Ser Trp Leu 
    290                 295                 300                 


Thr Ser Asp Leu Val Met Thr Leu Pro Asn Ile Ala Arg Val Gly Thr 
305                 310                 315                 320 


Val Leu Gly Phe Leu Gln Arg Gly Ala Leu Leu Pro Glu Phe Ser His 
                325                 330                 335     


Tyr Val Glu Thr Arg Leu Ala Leu Ala Ala Asp Pro Thr Phe Cys Ala 
            340                 345                 350         


Ser Leu Lys Ala Glu Leu Asp Leu Glu Glu Arg Val Met Gly Pro Arg 
        355                 360                 365             


Cys Ser Gln Cys Asp Tyr Ile Met Leu Gln Asn Leu Ser Ser Gly Leu 
    370                 375                 380                 


Met Gln Asn Leu Ser Ala Gly Gln Leu His His Gln Ile Phe Ala Thr 
385                 390                 395                 400 


Tyr Ala Ala Val Tyr Ser Val Ala Gln Ala Leu His Asn Thr Leu Gln 
                405                 410                 415     


Cys Asn Val Ser His Cys His Thr Ser Glu Pro Val Gln Pro Trp Gln 
            420                 425                 430         


Leu Leu Glu Asn Met Tyr Asn Met Ser Phe Arg Ala Arg Asp Leu Thr 
        435                 440                 445             


Leu Gln Phe Asp Ala Lys Gly Ser Val Asp Met Glu Tyr Asp Leu Lys 
    450                 455                 460                 


Met Trp Val Trp Gln Ser Pro Thr Pro Val Leu His Thr Val Gly Thr 
465                 470                 475                 480 


Phe Asn Gly Thr Leu Gln Leu Gln His Ser Lys Met Tyr Trp Pro Gly 
                485                 490                 495     


Asn Gln Val Pro Val Ser Gln Cys Ser Arg Gln Cys Lys Asp Gly Gln 
            500                 505                 510         


Val Arg Arg Val Lys Gly Phe His Ser Cys Cys Tyr Asp Cys Val Asp 
        515                 520                 525             


Cys Lys Ala Gly Ser Tyr Arg Lys His Pro Asp Asp Phe Thr Cys Thr 
    530                 535                 540                 


Pro Cys Gly Lys Asp Gln Trp Ser Pro Glu Lys Ser Thr Thr Cys Leu 
545                 550                 555                 560 


Pro Arg Arg Pro Lys Phe Leu Glu Trp Gly Glu Pro Ala Val Leu Leu 
                565                 570                 575     


Leu Leu Leu Leu Leu Ser Leu Ala Leu Gly Leu Val Leu Ala Ala Leu 
            580                 585                 590         


Gly Leu Phe Val His His Arg Asp Ser Pro Leu Val Gln Ala Ser Gly 
        595                 600                 605             


Gly Pro Leu Ala Cys Phe Gly Leu Val Cys Leu Gly Leu Val Cys Leu 
    610                 615                 620                 


Ser Val Leu Leu Phe Pro Gly Gln Pro Ser Pro Ala Arg Cys Leu Ala 
625                 630                 635                 640 


Gln Gln Pro Leu Ser His Leu Pro Leu Thr Gly Cys Leu Ser Thr Leu 
                645                 650                 655     


Phe Leu Gln Ala Ala Glu Ile Phe Val Glu Ser Glu Leu Pro Leu Ser 
            660                 665                 670         


Trp Ala Asp Arg Leu Ser Gly Cys Leu Arg Gly Pro Trp Ala Trp Leu 
        675                 680                 685             


Val Val Leu Leu Ala Met Leu Val Glu Val Ala Leu Cys Thr Trp Tyr 
    690                 695                 700                 


Leu Val Ala Phe Pro Pro Glu Val Val Thr Asp Trp His Met Leu Pro 
705                 710                 715                 720 


Thr Glu Ala Leu Val His Cys Arg Thr Arg Ser Trp Val Ser Phe Gly 
                725                 730                 735     


Leu Ala His Ala Thr Asn Ala Thr Leu Ala Phe Leu Cys Phe Leu Gly 
            740                 745                 750         


Thr Phe Leu Val Arg Ser Gln Pro Gly Arg Tyr Asn Arg Ala Arg Gly 
        755                 760                 765             


Leu Thr Phe Ala Met Leu Ala Tyr Phe Ile Trp Val Ser Phe Val Pro 
    770                 775                 780                 


Leu Leu Ala Asn Val Gln Val Val Leu Arg Pro Ala Val Gln Met Gly 
785                 790                 795                 800 


Ala Leu Leu Leu Cys Val Leu Gly Ile Leu Ala Ala Phe His Leu Pro 
                805                 810                 815     


Arg Cys Tyr Leu Leu Met Arg Gln Pro Gly Leu Asn Thr Pro Glu Phe 
            820                 825                 830         


Phe Leu Gly Gly Gly Pro Gly Asp Ala Gln Gly Gln Asn Asp Gly Asn 
        835                 840                 845             


Thr Gly Asn Gln Gly Lys His Glu 
    850                 855     


<210>  4
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Gly Pro Ala Val Leu Gly Leu Ser Leu Trp Ala Leu Leu His 
1               5                   10                  15      


Pro Gly Thr Gly Ala Pro Leu Cys Leu Ser Gln Gln Leu Arg Met Lys 
            20                  25                  30          


Gly Asp Tyr Val Leu Gly Gly Leu Phe Pro Leu Gly Glu Ala Glu Glu 
        35                  40                  45              


Ala Gly Leu Arg Ser Arg Thr Arg Pro Ser Ser Pro Val Cys Thr Arg 
    50                  55                  60                  


Phe Ser Ser Asn Gly Leu Leu Trp Ala Leu Ala Met Lys Met Ala Val 
65                  70                  75                  80  


Glu Glu Ile Asn Asn Lys Ser Asp Leu Leu Pro Gly Leu Arg Leu Gly 
                85                  90                  95      


Tyr Asp Leu Phe Asp Thr Cys Ser Glu Pro Val Val Ala Met Lys Pro 
            100                 105                 110         


Ser Leu Met Phe Leu Ala Lys Ala Gly Ser Arg Asp Ile Ala Ala Tyr 
        115                 120                 125             


Cys Asn Tyr Thr Gln Tyr Gln Pro Arg Val Leu Ala Val Ile Gly Pro 
    130                 135                 140                 


His Ser Ser Glu Leu Ala Met Val Thr Gly Lys Phe Phe Ser Phe Phe 
145                 150                 155                 160 


Leu Met Pro Gln Val Ser Tyr Gly Ala Ser Met Glu Leu Leu Ser Ala 
                165                 170                 175     


Arg Glu Thr Phe Pro Ser Phe Phe Arg Thr Val Pro Ser Asp Arg Val 
            180                 185                 190         


Gln Leu Thr Ala Ala Ala Glu Leu Leu Gln Glu Phe Gly Trp Asn Trp 
        195                 200                 205             


Val Ala Ala Leu Gly Ser Asp Asp Glu Tyr Gly Arg Gln Gly Leu Ser 
    210                 215                 220                 


Ile Phe Ser Ala Leu Ala Ala Ala Arg Gly Ile Cys Ile Ala His Glu 
225                 230                 235                 240 


Gly Leu Val Pro Leu Pro Arg Ala Asp Asp Ser Arg Leu Gly Lys Val 
                245                 250                 255     


Gln Asp Val Leu His Gln Val Asn Gln Ser Ser Val Gln Val Val Leu 
            260                 265                 270         


Leu Phe Ala Ser Val His Ala Ala His Ala Leu Phe Asn Tyr Ser Ile 
        275                 280                 285             


Ser Ser Arg Leu Ser Pro Lys Val Trp Val Ala Ser Glu Ala Trp Leu 
    290                 295                 300                 


Thr Ser Asp Leu Val Met Gly Leu Pro Gly Met Ala Gln Met Gly Thr 
305                 310                 315                 320 


Val Leu Gly Phe Leu Gln Arg Gly Ala Gln Leu His Glu Phe Pro Gln 
                325                 330                 335     


Tyr Val Lys Thr His Leu Ala Leu Ala Thr Asp Pro Ala Phe Cys Ser 
            340                 345                 350         


Ala Leu Gly Glu Arg Glu Gln Gly Leu Glu Glu Asp Val Val Gly Gln 
        355                 360                 365             


Arg Cys Pro Gln Cys Asp Cys Ile Thr Leu Gln Asn Val Ser Ala Gly 
    370                 375                 380                 


Leu Asn His His Gln Thr Phe Ser Val Tyr Ala Ala Val Tyr Ser Val 
385                 390                 395                 400 


Ala Gln Ala Leu His Asn Thr Leu Gln Cys Asn Ala Ser Gly Cys Pro 
                405                 410                 415     


Ala Gln Asp Pro Val Lys Pro Trp Gln Leu Leu Glu Asn Met Tyr Asn 
            420                 425                 430         


Leu Thr Phe His Val Gly Gly Leu Pro Leu Arg Phe Asp Ser Ser Gly 
        435                 440                 445             


Asn Val Asp Met Glu Tyr Asp Leu Lys Leu Trp Val Trp Gln Gly Ser 
    450                 455                 460                 


Val Pro Arg Leu His Asp Val Gly Arg Phe Asn Gly Ser Leu Arg Thr 
465                 470                 475                 480 


Glu Arg Leu Lys Ile Arg Trp His Thr Ser Asp Asn Gln Lys Pro Val 
                485                 490                 495     


Ser Arg Cys Ser Arg Gln Cys Gln Glu Gly Gln Val Arg Arg Val Lys 
            500                 505                 510         


Gly Phe His Ser Cys Cys Tyr Asp Cys Val Asp Cys Glu Ala Gly Ser 
        515                 520                 525             


Tyr Arg Gln Asn Pro Asp Asp Ile Ala Cys Thr Phe Cys Gly Gln Asp 
    530                 535                 540                 


Glu Trp Ser Pro Glu Arg Ser Thr Arg Cys Phe Arg Arg Arg Ser Arg 
545                 550                 555                 560 


Phe Leu Ala Trp Gly Glu Pro Ala Val Leu Leu Leu Leu Leu Leu Leu 
                565                 570                 575     


Ser Leu Ala Leu Gly Leu Val Leu Ala Ala Leu Gly Leu Phe Val His 
            580                 585                 590         


His Arg Asp Ser Pro Leu Val Gln Ala Ser Gly Gly Pro Leu Ala Cys 
        595                 600                 605             


Phe Gly Leu Val Cys Leu Gly Leu Val Cys Leu Ser Val Leu Leu Phe 
    610                 615                 620                 


Pro Gly Gln Pro Ser Pro Ala Arg Cys Leu Ala Gln Gln Pro Leu Ser 
625                 630                 635                 640 


His Leu Pro Leu Thr Gly Cys Leu Ser Thr Leu Phe Leu Gln Ala Ala 
                645                 650                 655     


Glu Ile Phe Val Glu Ser Glu Leu Pro Leu Ser Trp Ala Asp Arg Leu 
            660                 665                 670         


Ser Gly Cys Leu Arg Gly Pro Trp Ala Trp Leu Val Val Leu Leu Ala 
        675                 680                 685             


Met Leu Val Glu Val Ala Leu Cys Thr Trp Tyr Leu Val Ala Phe Pro 
    690                 695                 700                 


Pro Glu Val Val Thr Asp Trp His Met Leu Pro Thr Glu Ala Leu Val 
705                 710                 715                 720 


His Cys Arg Thr Arg Ser Trp Val Ser Phe Gly Leu Ala His Ala Thr 
                725                 730                 735     


Asn Ala Thr Leu Ala Phe Leu Cys Phe Leu Gly Thr Phe Leu Val Arg 
            740                 745                 750         


Ser Gln Pro Gly Arg Tyr Asn Arg Ala Arg Gly Leu Thr Phe Ala Met 
        755                 760                 765             


Leu Ala Tyr Phe Ile Thr Trp Val Ser Phe Val Pro Leu Leu Ala Asn 
    770                 775                 780                 


Val Gln Val Val Leu Arg Pro Ala Val Gln Met Gly Ala Leu Leu Leu 
785                 790                 795                 800 


Cys Val Leu Gly Ile Leu Ala Ala Phe His Leu Pro Arg Cys Tyr Leu 
                805                 810                 815     


Leu Met Arg Gln Pro Gly Leu Asn Thr Pro Glu Phe Phe Leu Gly Gly 
            820                 825                 830         


Gly Pro Gly Asp Ala Gln Gly Gln Asn Asp Gly Asn Thr Gly Asn Gln 
        835                 840                 845             


Gly Lys His Glu 
    850         


