                               SEQUENCE LISTING

<110> TSCAN THERAPEUTICS, INC.
 
<120> COMPOSITIONS AND METHODS FOR IDENTIFYING EPITOPES

<130> TTC-00325

<140> PCT/US2021/042311
<141> 2021-07-20

<150> 63/055,766
<151> 2020-07-23

<160> 70    

<170> PatentIn version 3.5

<210> 1
<211> 1200
<212> DNA
<213> Homo sapiens

<400> 1
atgccctgga gtagtcgcgg ggctctcctg cgggaccttg tgctgggagt actcgggaca       60

gcggcgttcc tgttggacct cggaactgac ttgtgggccg ccgtccagta cgcacttggt      120

ggaaggtacc tttgggcggc gctggtcctg gccctcttgg ggctggcaag cgtcgctctc      180

cagctcttta gctggctgtg gcttcgcgca gatcccgctg ggctgcatgg gtcccagccg      240

ccaaggagat gcctggctct gctccatctt ctccagctcg ggtatcttta cagatgcgta      300

caagagttgc gccagggcct tcttgtttgg caacaagagg aaccaagtga gttcgacctc      360

gcctatgcgg atttccttgc gttggatatc tccatgcttc ggctcttcga aacattcctt      420

gagaccgcgc cacaattgac ccttgtactt gcaatcatgc tgcaatctgg acgagcagaa      480

tactaccaat gggtgggaat ctgcacatcc ttcctgggca tcagttgggc cctccttgat      540

tatcatcgcg ccttgagaac ttgtttgcca agcaaaccat tgttgggcct cggatcctct      600

gttatttatt ttctctggaa tctgctgctt ttgtggccgc gagtactcgc tgttgcgctt      660

ttttccgcgt tgttcccttc ctacgtcgcg ctccattttc tcggcctgtg gctggttctg      720

ctgttgtggg tttggctgca agggacggac tttatgccag acccgtccag tgagtggctt      780

taccgggtta cagttgcgac catactttat ttctcctggt ttaatgtcgc agagggacga      840

actcgcggga gagccataat ccacttcgca ttcctcctct cagattcaat actcctggtc      900

gccacctggg taacacactc atcatggctc ccaagtggga tacctttgca attgtggttg      960

ccggttggct gcgggtgttt cttcctgggt ctcgctctta gacttgtcta ttatcattgg     1020

ctgcacccga gttgctgctg gaagcctgac ccggtgggac ctgattttgg tagagaattc     1080

gcgcggtcct tgctctcccc agaaggctac cagttgcccc aaaatagacg catgactcac     1140

cttgcccaga agttctttcc caaagccaag gacgaggcag cttctcctgt caaggggtag     1200


<210> 2
<211> 399
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Trp Ser Ser Arg Gly Ala Leu Leu Arg Asp Leu Val Leu Gly 
1               5                   10                  15      


Val Leu Gly Thr Ala Ala Phe Leu Leu Asp Leu Gly Thr Asp Leu Trp 
            20                  25                  30          


Ala Ala Val Gln Tyr Ala Leu Gly Gly Arg Tyr Leu Trp Ala Ala Leu 
        35                  40                  45              


Val Leu Ala Leu Leu Gly Leu Ala Ser Val Ala Leu Gln Leu Phe Ser 
    50                  55                  60                  


Trp Leu Trp Leu Arg Ala Asp Pro Ala Gly Leu His Gly Ser Gln Pro 
65                  70                  75                  80  


Pro Arg Arg Cys Leu Ala Leu Leu His Leu Leu Gln Leu Gly Tyr Leu 
                85                  90                  95      


Tyr Arg Cys Val Gln Glu Leu Arg Gln Gly Leu Leu Val Trp Gln Gln 
            100                 105                 110         


Glu Glu Pro Ser Glu Phe Asp Leu Ala Tyr Ala Asp Phe Leu Ala Leu 
        115                 120                 125             


Asp Ile Ser Met Leu Arg Leu Phe Glu Thr Phe Leu Glu Thr Ala Pro 
    130                 135                 140                 


Gln Leu Thr Leu Val Leu Ala Ile Met Leu Gln Ser Gly Arg Ala Glu 
145                 150                 155                 160 


Tyr Tyr Gln Trp Val Gly Ile Cys Thr Ser Phe Leu Gly Ile Ser Trp 
                165                 170                 175     


Ala Leu Leu Asp Tyr His Arg Ala Leu Arg Thr Cys Leu Pro Ser Lys 
            180                 185                 190         


Pro Leu Leu Gly Leu Gly Ser Ser Val Ile Tyr Phe Leu Trp Asn Leu 
        195                 200                 205             


Leu Leu Leu Trp Pro Arg Val Leu Ala Val Ala Leu Phe Ser Ala Leu 
    210                 215                 220                 


Phe Pro Ser Tyr Val Ala Leu His Phe Leu Gly Leu Trp Leu Val Leu 
225                 230                 235                 240 


Leu Leu Trp Val Trp Leu Gln Gly Thr Asp Phe Met Pro Asp Pro Ser 
                245                 250                 255     


Ser Glu Trp Leu Tyr Arg Val Thr Val Ala Thr Ile Leu Tyr Phe Ser 
            260                 265                 270         


Trp Phe Asn Val Ala Glu Gly Arg Thr Arg Gly Arg Ala Ile Ile His 
        275                 280                 285             


Phe Ala Phe Leu Leu Ser Asp Ser Ile Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Thr His Ser Ser Trp Leu Pro Ser Gly Ile Pro Leu Gln Leu Trp Leu 
305                 310                 315                 320 


Pro Val Gly Cys Gly Cys Phe Phe Leu Gly Leu Ala Leu Arg Leu Val 
                325                 330                 335     


Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Val 
            340                 345                 350         


Gly Pro Asp Phe Gly Arg Glu Phe Ala Arg Ser Leu Leu Ser Pro Glu 
        355                 360                 365             


Gly Tyr Gln Leu Pro Gln Asn Arg Arg Met Thr His Leu Ala Gln Lys 
    370                 375                 380                 


Phe Phe Pro Lys Ala Lys Asp Glu Ala Ala Ser Pro Val Lys Gly 
385                 390                 395                 


<210> 3
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
gtgggacctg attttggtag agaattc                                           27


<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Val Gly Pro Asp Phe Gly Arg Glu Phe 
1               5                   


<210> 5
<211> 1212
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atgccctgga gtagtcgcgg ggctctcctg cgggaccttg tgctgggagt actcgggaca       60

gcggcgttcc tgttggacct cggaactgac ttgtgggccg ccgtccagta cgcacttggt      120

ggaaggtacc tttgggcggc gctggtcctg gccctcttgg ggctggcaag cgtcgctctc      180

cagctcttta gctggctgtg gcttcgcgca gatcccgctg ggctgcatgg gtcccagccg      240

ccaaggagat gcctggctct gctccatctt ctccagctcg ggtatcttta cagatgcgta      300

caagagttgc gccagggcct tcttgtttgg caacaagagg aaccaagtga gttcgacctc      360

gcctatgcgg atttccttgc gttggatatc tccatgcttc ggctcttcga aacattcctt      420

gagaccgcgc cacaattgac ccttgtactt gcaatcatgc tgcaatctgg acgagcagaa      480

tactaccaat gggtgggaat ctgcacatcc ttcctgggca tcagttgggc cctccttgat      540

tatcatcgcg ccttgagaac ttgtttgcca agcaaaccat tgttgggcct cggatcctct      600

gttatttatt ttctctggaa tctgctgctt ttgtggccgc gagtactcgc tgttgcgctt      660

ttttccgcgt tgttcccttc ctacgtcgcg ctccattttc tcggcctgtg gctggttctg      720

ctgttgtggg tttggctgca agggacggac tttatgccag acccgtccag tgagtggctt      780

taccgggtta cagttgcgac catactttat ttctcctggt ttaatgtcgc agagggacga      840

actcgcggga gagccataat ccacttcgca ttcctcctct cagattcaat actcctggtc      900

gccacctggg taacacactc atcatggctc ccaagtggga tacctttgca attgtggttg      960

ccggttggct gcgggtgttt cttcctgggt ctcgctctta gacttgtcta ttatcattgg     1020

ctgcacccga gttgctgctg gaagcctgac ccgggatcgg tgggacctga ttttggtaga     1080

gaattcggca gtgcgcggtc cttgctctcc ccagaaggct accagttgcc ccaaaataga     1140

cgcatgactc accttgccca gaagttcttt cccaaagcca aggacgaggc agcttctcct     1200

gtcaaggggt ag                                                         1212


<210> 6
<211> 403
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Pro Trp Ser Ser Arg Gly Ala Leu Leu Arg Asp Leu Val Leu Gly 
1               5                   10                  15      


Val Leu Gly Thr Ala Ala Phe Leu Leu Asp Leu Gly Thr Asp Leu Trp 
            20                  25                  30          


Ala Ala Val Gln Tyr Ala Leu Gly Gly Arg Tyr Leu Trp Ala Ala Leu 
        35                  40                  45              


Val Leu Ala Leu Leu Gly Leu Ala Ser Val Ala Leu Gln Leu Phe Ser 
    50                  55                  60                  


Trp Leu Trp Leu Arg Ala Asp Pro Ala Gly Leu His Gly Ser Gln Pro 
65                  70                  75                  80  


Pro Arg Arg Cys Leu Ala Leu Leu His Leu Leu Gln Leu Gly Tyr Leu 
                85                  90                  95      


Tyr Arg Cys Val Gln Glu Leu Arg Gln Gly Leu Leu Val Trp Gln Gln 
            100                 105                 110         


Glu Glu Pro Ser Glu Phe Asp Leu Ala Tyr Ala Asp Phe Leu Ala Leu 
        115                 120                 125             


Asp Ile Ser Met Leu Arg Leu Phe Glu Thr Phe Leu Glu Thr Ala Pro 
    130                 135                 140                 


Gln Leu Thr Leu Val Leu Ala Ile Met Leu Gln Ser Gly Arg Ala Glu 
145                 150                 155                 160 


Tyr Tyr Gln Trp Val Gly Ile Cys Thr Ser Phe Leu Gly Ile Ser Trp 
                165                 170                 175     


Ala Leu Leu Asp Tyr His Arg Ala Leu Arg Thr Cys Leu Pro Ser Lys 
            180                 185                 190         


Pro Leu Leu Gly Leu Gly Ser Ser Val Ile Tyr Phe Leu Trp Asn Leu 
        195                 200                 205             


Leu Leu Leu Trp Pro Arg Val Leu Ala Val Ala Leu Phe Ser Ala Leu 
    210                 215                 220                 


Phe Pro Ser Tyr Val Ala Leu His Phe Leu Gly Leu Trp Leu Val Leu 
225                 230                 235                 240 


Leu Leu Trp Val Trp Leu Gln Gly Thr Asp Phe Met Pro Asp Pro Ser 
                245                 250                 255     


Ser Glu Trp Leu Tyr Arg Val Thr Val Ala Thr Ile Leu Tyr Phe Ser 
            260                 265                 270         


Trp Phe Asn Val Ala Glu Gly Arg Thr Arg Gly Arg Ala Ile Ile His 
        275                 280                 285             


Phe Ala Phe Leu Leu Ser Asp Ser Ile Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Thr His Ser Ser Trp Leu Pro Ser Gly Ile Pro Leu Gln Leu Trp Leu 
305                 310                 315                 320 


Pro Val Gly Cys Gly Cys Phe Phe Leu Gly Leu Ala Leu Arg Leu Val 
                325                 330                 335     


Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Gly 
            340                 345                 350         


Ser Val Gly Pro Asp Phe Gly Arg Glu Phe Gly Ser Ala Arg Ser Leu 
        355                 360                 365             


Leu Ser Pro Glu Gly Tyr Gln Leu Pro Gln Asn Arg Arg Met Thr His 
    370                 375                 380                 


Leu Ala Gln Lys Phe Phe Pro Lys Ala Lys Asp Glu Ala Ala Ser Pro 
385                 390                 395                 400 


Val Lys Gly 
            


<210> 7
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ggatcggtgg gacctgattt tggtagagaa ttcggcagt                              39


<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Ser Val Gly Pro Asp Phe Gly Arg Glu Phe Gly Ser 
1               5                   10              


<210> 9
<211> 2178
<212> DNA
<213> Homo sapiens

<400> 9
gagggctgcg cccacctcct tcctgcctcg gcaaccccgg gccctgaggg caggccccaa       60

ccgcggagga gcaggagagg gcggaggccg gcgggccatg ccctggtcgt cccgcggcgc      120

cctccttcgg gacctggtcc tgggcgtgct gggcaccgcc gccttcctgc tcgacctggg      180

caccgacctg tgggccgccg tccagtatgc gctcggcggc cgctacctgt gggcggcgct      240

ggtgctggcg ctgctgggcc tggcctccgt ggcgctgcag ctcttcagct ggctctggct      300

gcgcgctgac cctgccggcc tgcacgggtc gcagcccccg cgccgctgcc tggcgctgct      360

gcatctcctg cagctgggtt acctgtacag gtgcgtgcag gagctgcggc aggggctgct      420

ggtgtggcag caggaggagc cctctgagtt tgacttggcc tacgccgact tcctcgccct      480

ggacatcagc atgctgcggc tcttcgagac cttcttggag acggcaccac agctcacgct      540

ggtgctggcc atcatgctgc agagtggccg ggctgagtac taccagtggg ttggcatctg      600

cacatccttc ctgggcatct cgtgggcact gctcgactac caccgggcct tgcgcacctg      660

cctcccctcc aagccgctcc tgggcctggg ctcctccgtg atctacttcc tgtggaacct      720

gctgctgctg tggccccgag tcctggctgt ggccctgttc tcagccctct tccccagcta      780

tgtggccctg cacttcctgg gcctgtggct ggtactgctg ctctgggtct ggcttcaggg      840

cacagacttc atgccggacc ccagctccga gtggctgtac cgggtgacgg tggccaccat      900

cctctatttc tcctggttca acgtggctga gggccgcacc cgaggccggg ccatcatcca      960

cttcgccttc ctcctgagtg acagcattct cctggtggcc acctgggtga ctcatagctc     1020

ctggctgccc agcgggattc cactgcagct gtggctgcct gtgggatgcg gctgcttctt     1080

tctgggcctg gctctgcggc ttgtgtacta ccactggctg caccctagct gctgctggaa     1140

gcccgaccct gaccaggtag acggggcccg gagtctgctt tctccagagg ggtatcagct     1200

gcctcagaac aggcgcatga cccatttagc acagaagttt ttccccaagg ctaaggatga     1260

ggctgcttcg ccagtgaagg gataggtgaa cggcgtcctt tgaagcagga tcagacccag     1320

ccagcagaga tggagagtga ctctgttggc agaaggcagg cgaggataag ctaacgatgc     1380

tgctgtggcc tctatgcact cagcaagagc gggacgcctg tgctgggccg ggcaccaggg     1440

atggtgctga gtcgggcaga ggcctccttt caaggagttc acagtgaaca agatgagaag     1500

ggctgggccc tggagggtca agagccccaa ttatgtacaa gacactttgg gaggaaagaa     1560

gactaccttt tccccctgcc attggtatag ctggtgcccc aaaacttcca cctccctccc     1620

tggctacctc taaaatgact ggtataggtg ctgccccacc ccttagctcc cctatcctgg     1680

gctaggaggc cacaggggct gtcctctaga attcttcctt ccctccccca caccattcat     1740

tcaattcatg aaacaaatct ttgccaagag cagtttatgt gccaggaaca tcattctgtc     1800

cttgcaacct ggaacaagac cagctaccag cctagcttca tccgctactt gcaccaacca     1860

gtcccgggtt agatcccaaa tgctagaagc cagggatgcc caactctggg tggccccagt     1920

cagaacctct gggatctcag tgaagctggc ctggcctctg ctcctgctct caaggggctg     1980

cttttcaacc aagagccttg tgagcctggt ctgagccttg cacagccact gagtattttt     2040

tttgccttag ccagtgtacc tcctacctca gtctatgtga gaggaagaga atgtgtgtgc     2100

ctgtgggtct ctacaagtga cagatgtgtt gttttcaaca gtattattag gttatgaata     2160

aagcctcatg aaatcctc                                                   2178


<210> 10
<211> 395
<212> PRT
<213> Homo sapiens

<400> 10
Met Pro Trp Ser Ser Arg Gly Ala Leu Leu Arg Asp Leu Val Leu Gly 
1               5                   10                  15      


Val Leu Gly Thr Ala Ala Phe Leu Leu Asp Leu Gly Thr Asp Leu Trp 
            20                  25                  30          


Ala Ala Val Gln Tyr Ala Leu Gly Gly Arg Tyr Leu Trp Ala Ala Leu 
        35                  40                  45              


Val Leu Ala Leu Leu Gly Leu Ala Ser Val Ala Leu Gln Leu Phe Ser 
    50                  55                  60                  


Trp Leu Trp Leu Arg Ala Asp Pro Ala Gly Leu His Gly Ser Gln Pro 
65                  70                  75                  80  


Pro Arg Arg Cys Leu Ala Leu Leu His Leu Leu Gln Leu Gly Tyr Leu 
                85                  90                  95      


Tyr Arg Cys Val Gln Glu Leu Arg Gln Gly Leu Leu Val Trp Gln Gln 
            100                 105                 110         


Glu Glu Pro Ser Glu Phe Asp Leu Ala Tyr Ala Asp Phe Leu Ala Leu 
        115                 120                 125             


Asp Ile Ser Met Leu Arg Leu Phe Glu Thr Phe Leu Glu Thr Ala Pro 
    130                 135                 140                 


Gln Leu Thr Leu Val Leu Ala Ile Met Leu Gln Ser Gly Arg Ala Glu 
145                 150                 155                 160 


Tyr Tyr Gln Trp Val Gly Ile Cys Thr Ser Phe Leu Gly Ile Ser Trp 
                165                 170                 175     


Ala Leu Leu Asp Tyr His Arg Ala Leu Arg Thr Cys Leu Pro Ser Lys 
            180                 185                 190         


Pro Leu Leu Gly Leu Gly Ser Ser Val Ile Tyr Phe Leu Trp Asn Leu 
        195                 200                 205             


Leu Leu Leu Trp Pro Arg Val Leu Ala Val Ala Leu Phe Ser Ala Leu 
    210                 215                 220                 


Phe Pro Ser Tyr Val Ala Leu His Phe Leu Gly Leu Trp Leu Val Leu 
225                 230                 235                 240 


Leu Leu Trp Val Trp Leu Gln Gly Thr Asp Phe Met Pro Asp Pro Ser 
                245                 250                 255     


Ser Glu Trp Leu Tyr Arg Val Thr Val Ala Thr Ile Leu Tyr Phe Ser 
            260                 265                 270         


Trp Phe Asn Val Ala Glu Gly Arg Thr Arg Gly Arg Ala Ile Ile His 
        275                 280                 285             


Phe Ala Phe Leu Leu Ser Asp Ser Ile Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Thr His Ser Ser Trp Leu Pro Ser Gly Ile Pro Leu Gln Leu Trp Leu 
305                 310                 315                 320 


Pro Val Gly Cys Gly Cys Phe Phe Leu Gly Leu Ala Leu Arg Leu Val 
                325                 330                 335     


Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Asp 
            340                 345                 350         


Gln Val Asp Gly Ala Arg Ser Leu Leu Ser Pro Glu Gly Tyr Gln Leu 
        355                 360                 365             


Pro Gln Asn Arg Arg Met Thr His Leu Ala Gln Lys Phe Phe Pro Lys 
    370                 375                 380                 


Ala Lys Asp Glu Ala Ala Ser Pro Val Lys Gly 
385                 390                 395 


<210> 11
<211> 4238
<212> DNA
<213> Mus musculus

<400> 11
gacgactgcc ccgccccctt cctgccggac tagcggggcg ggagggcagg tccgcggttg       60

tgtggttgct tggagaggat catgcctctg tccgtgcacc accatgtggc cttagacgtg      120

gtcgtaggcc tggtgagtat cttgtctttc ctgctggatc tggtcgctga cctgtgggcc      180

gttgtccagt acgtgctcct tggccgttat ctgtgggccg cgctggtact ggtcctgctg      240

ggccaagctt cggtgctgct gcagctcttc agctggctct ggctgacagc tgatcccacc      300

gagctgcacc attcgcagct ctcgcgtcct ttcctggctc tgctgcacct gctgcagctc      360

ggctacctgt ataggtgttt gcacggaatg catcaagggc tgtccatgtg ctaccaggag      420

atgccatccg agtgtgacct ggcctacgca gactttctct ccctggacat cagcatgctg      480

aagcttttcg agagcttcct ggaggcgacg ccacagctca cactggtgct ggcaattgta      540

ttgcagaatg gccaggcgga atactaccag tggtttggca tcagctcatc ctttcttggc      600

atctcgtggg cactgctgga ttaccatcgg tctctgcgta cctgtcttcc ctccaagcca      660

cgcctgggcc ggagttcctc tgctatctac ttcctgtgga acctgctgct gctggggccc      720

agaatctgtg ccatcgcctt gttctcagct gtcttcccct actatgtggc cctgcatttc      780

ttcagcctgt ggctggtact tttgttctgg atctggcttc aaggcacaaa ttttatgcct      840

gactccaaag gtgagtggct gtaccgggtg acaatggccc tcatcctcta tttctcctgg      900

ttcaacgtgt ctgggggccg cactcgaggc cgggccgtca tccacctgat cttcatcttc      960

agtgacagtg ttctgctggt caccacctcc tgggtgacac acggcacctg gctgcccagt     1020

gggatctcat tgctgatgtg ggtgacaata ggaggagcct gcttcttcct gggactggct     1080

ttgcgtgtga tctactacct ctggctgcac cctagctgca gctgggaccc tgacctcgtg     1140

gatgggaccc taggactcct ttctccccat cgtcctccta agctgattta taacaggcgt     1200

gccaccctgt tagcagagaa cttcttcgcc aaggccaaag ctcgggctgt cctgacagag     1260

gaggtgcagc tgaatggagt cctctgaggc agggtctgat tcagccagtg aggaagataa     1320

tgcgagtggg gccttgcaag ggacaaggcg ggccagtcat gtgcaagcca ttttttttct     1380

tctgaagccg atggaactgc tgtcagcaaa cactcggttg tttgttgttc tcacctctca     1440

ggtgattggt ggcgtcctgg ctcctggttc cctagcccgc tctagatgac acaagattct     1500

gggagaactc ttccctaccc catcccatcc attcacttca accaacaaat gctaaaggca     1560

ctttatgttc tgggaacacc atcctggctt ctgaactgcc tgccactcta gcttctttcc     1620

ctgcccacct ggacagatcc tgggtagact cctaaacagt gaggccaggt atgtccctcc     1680

agtgtcctga tgctcaggcc acctttatac caagtgcctt atggacctgt ggtctaggcc     1740

atgtgatgcc cagtaagtat tttcattctc ctacctcagt ctatgtggaa gaacatatat     1800

gcatgtgttt aacagtatta aagcctcatg agattctcca gaccagtatg taccactaag     1860

tgtagtctat caccctttac agacacgtag aaggcgcctg gaacccctta aaactgacac     1920

agacccctgg catacaaatg tgggcatagg tttgacttaa ttttgcttcc caagacgcag     1980

gggctagtga gcccgagccg gttgatcatt cggctagcag aactcatggg cagatgctag     2040

tgtattcttt tagcagctcc gtactgagcc taaagaggac ttgaggatgg ggatggcagg     2100

tttgaggggc tggatggaag gtaaaggatt gggggttctt tttgggtgag aggtgcagtg     2160

gcttctggga tgtggtcaat agctccgtgg aggtggcgtg ttctgctctc ggaggtttgt     2220

ggtcttgttg ggaaaaggga acaggagaga ggctccaggg gcagaagaaa aggttccagg     2280

tcccagtgct gggacccaga tagttctagc agtcattcat ttatttgtgt ggacgtgaaa     2340

taacctgtga cccaaacaag caccaagtac tgaaagaaaa ccagatggag aggtgagagg     2400

gaggatgtat gttgtgggtg gaagttgcag ctttataaaa aaccattggg gaggacccct     2460

ctgagaaact gaggcataga ctgtaagcta cttcagcagt gactgcagca tggagtctgc     2520

gtggtttgtt ggagaaggaa tctgcgaatg ctgttccctg tggcacagca accccactgt     2580

aagaggactg tggggtgcgg ttggctcaca gccaaggagg ctgcagagat gcaggtgggg     2640

gcctggaaga ggctctggga gaaggtactt cttatactaa aaggtacagg ctgactatgg     2700

acagaaagga cctaatttcc agacctgaat tttacagacc aggaaaagga gccaaagtgg     2760

ttgttgatgt taaaagggtc tgaaaaacag tcaccacctc cgtgttcact ctcatggaaa     2820

aacggatgta atcacaccag aaggtgtcat cctctaaaca gatgccccca caggtacaca     2880

cctgaaatca ctgttactct catttatgaa aatggtaaga tagggatgag ccagtgtgac     2940

acacctacca gtctgggcaa ggacatcagg agttcagact cctcagtgac aatgtcagag     3000

gccagcttgg gctacatgag accctgtctc caacaaaatg aaattatttt atttatttat     3060

ttatttggct ttttgagacg gggtttctct gtgtagccct ggctgtcctg gaactcactc     3120

tgtagaccag gctatcctca aactcagaaa tctgcctgcc tctgcctccc aagtgctggg     3180

attaaaggca tgcgccacca cgcctggcac attttttttt taaattaaaa aaagaaagac     3240

gttactaccc tgctcttgtt ttgtgacaca caatctggtc tgagaggacc ctgagcacat     3300

cttccttcct tcaacactac cgtgctaagt tcttaaaatc tgggacttaa aaccaggtta     3360

gtgacattac ccgtagttag gatgtttggt ttgttgggga ttggttctaa tgctctgtct     3420

taattcggct cccagaatca cacgggaatc tgctctgcta aaggaagcct gtcactagtt     3480

ggctgtgatt gggaaataaa gttgcccagg gctggctggg caggaaagag gcgggacttt     3540

taggttgtga gggcaaggaa ccccggggag ttggaagcag agggatttca ctgcgcagtt     3600

gggtctgggg cagcagagat gaaatgatga cttagcaagt cgactcaggg aggttagggg     3660

ggtagaatgt atgctagtcg cacggagggt tagacacgtc cagccactga gctagtcaga     3720

gcatatcaaa gttagatggt gtgtgtctct cattcacaaa tcccgggaac acttggccag     3780

ccgggagtca ggggtctaag cactacaggg tttggaaacc agccaacact agaatctgca     3840

cttgtgactg agcaggggta cggacaacag ctaacagtct acttgagctg cactgcggct     3900

cagaagatca cttcccggag aaaattcacc ttggagtccg acatatctca cctttggaag     3960

ctagaaacaa cttctaattt ccttcactgg aacaatgggt aaaaagccct cttgtaagct     4020

agtgggggcc aatcagacca aatgtggcag aatgtagaac acctggttgg tgggacggga     4080

agtcaggatt tattgggttg cggcttaatt aatgctcagc acagactgac tcctccttgg     4140

taacgttcag cacactcgac agctctgaaa tccattccat ttctatacct taaaaagcag     4200

tgtattttag aaacaattca aataaacatt tctctcgc                             4238


<210> 12
<211> 401
<212> PRT
<213> Mus musculus

<400> 12
Met Pro Leu Ser Val His His His Val Ala Leu Asp Val Val Val Gly 
1               5                   10                  15      


Leu Val Ser Ile Leu Ser Phe Leu Leu Asp Leu Val Ala Asp Leu Trp 
            20                  25                  30          


Ala Val Val Gln Tyr Val Leu Leu Gly Arg Tyr Leu Trp Ala Ala Leu 
        35                  40                  45              


Val Leu Val Leu Leu Gly Gln Ala Ser Val Leu Leu Gln Leu Phe Ser 
    50                  55                  60                  


Trp Leu Trp Leu Thr Ala Asp Pro Thr Glu Leu His His Ser Gln Leu 
65                  70                  75                  80  


Ser Arg Pro Phe Leu Ala Leu Leu His Leu Leu Gln Leu Gly Tyr Leu 
                85                  90                  95      


Tyr Arg Cys Leu His Gly Met His Gln Gly Leu Ser Met Cys Tyr Gln 
            100                 105                 110         


Glu Met Pro Ser Glu Cys Asp Leu Ala Tyr Ala Asp Phe Leu Ser Leu 
        115                 120                 125             


Asp Ile Ser Met Leu Lys Leu Phe Glu Ser Phe Leu Glu Ala Thr Pro 
    130                 135                 140                 


Gln Leu Thr Leu Val Leu Ala Ile Val Leu Gln Asn Gly Gln Ala Glu 
145                 150                 155                 160 


Tyr Tyr Gln Trp Phe Gly Ile Ser Ser Ser Phe Leu Gly Ile Ser Trp 
                165                 170                 175     


Ala Leu Leu Asp Tyr His Arg Ser Leu Arg Thr Cys Leu Pro Ser Lys 
            180                 185                 190         


Pro Arg Leu Gly Arg Ser Ser Ser Ala Ile Tyr Phe Leu Trp Asn Leu 
        195                 200                 205             


Leu Leu Leu Gly Pro Arg Ile Cys Ala Ile Ala Leu Phe Ser Ala Val 
    210                 215                 220                 


Phe Pro Tyr Tyr Val Ala Leu His Phe Phe Ser Leu Trp Leu Val Leu 
225                 230                 235                 240 


Leu Phe Trp Ile Trp Leu Gln Gly Thr Asn Phe Met Pro Asp Ser Lys 
                245                 250                 255     


Gly Glu Trp Leu Tyr Arg Val Thr Met Ala Leu Ile Leu Tyr Phe Ser 
            260                 265                 270         


Trp Phe Asn Val Ser Gly Gly Arg Thr Arg Gly Arg Ala Val Ile His 
        275                 280                 285             


Leu Ile Phe Ile Phe Ser Asp Ser Val Leu Leu Val Thr Thr Ser Trp 
    290                 295                 300                 


Val Thr His Gly Thr Trp Leu Pro Ser Gly Ile Ser Leu Leu Met Trp 
305                 310                 315                 320 


Val Thr Ile Gly Gly Ala Cys Phe Phe Leu Gly Leu Ala Leu Arg Val 
                325                 330                 335     


Ile Tyr Tyr Leu Trp Leu His Pro Ser Cys Ser Trp Asp Pro Asp Leu 
            340                 345                 350         


Val Asp Gly Thr Leu Gly Leu Leu Ser Pro His Arg Pro Pro Lys Leu 
        355                 360                 365             


Ile Tyr Asn Arg Arg Ala Thr Leu Leu Ala Glu Asn Phe Phe Ala Lys 
    370                 375                 380                 


Ala Lys Ala Arg Ala Val Leu Thr Glu Glu Val Gln Leu Asn Gly Val 
385                 390                 395                 400 


Leu 
    


<210> 13
<211> 2671
<212> DNA
<213> Rattus norvegicus

<400> 13
tgtgaggacg tctgccgaag ggagcatgtg tgcgccatac agcacgtgga gttcgacact       60

tacgccacct gcttgcatgg tcttggtgcc aacctggtac ctggtttcct gctcatactg      120

actctgctga cgagcctaca cgtattggag gtgctatgac tgtaggcact gccagcctac      180

cctcttactt ggttcgtctt tctccctggt aaaactgggc aacattaccc aatggagaga      240

gagggagatg aattttgcca tcagtctgtg gagagtaagg tgggatggga catttggatt      300

caccagagag ggcgctaaga agcacatttc ttctgagttt tatgttttat ccacagagct      360

tgtttgcggt acatgtcttg gtgcattatt ccctttaata caaacatcaa actatcatgc      420

acttgatcgc cacagtaaag tgaacccgca ggaagatggg ccctggagag tctgtgcttt      480

tgagtccctg ctcaaggtct aaaactggga acccacgtgg tctgcaaaat cccttggtac      540

ttttaaataa aagacttttc tgatttggtt tcgcaacagt gcaaccgtga gggatcacag      600

ctgcgaccca gacactagtc ttgtggccac tcttgttaac tagagcctca aaaggcagaa      660

tccaaaccag tagaggcagg gctcaagaca gggagggctg ggggcggggt ctgggcggtg      720

ggaccgccta gggggcggag tcgtggactc gctcctcccc ggacggggcg agatggggaa      780

gttccgccca gcagcccggc ctctgggagg actgccccac ccccttcctg ccggactagc      840

cgggctggag ggcagatccg cggttgtgag gttgcctgga gggccatgcc tctgtccgtg      900

cacccccaag tggccttaga cgtggtcata ggtctggtga gtaccttgtc tttcctgttg      960

gacctggtcg ccgacctgtg ggccgtcgtc cagtacgtgc tcgttggccg ttacctgtgg     1020

gccgcgctgg tagtggtgct gctgggccaa gcctcggtgc tgctgcagct cttcagctgg     1080

ctctggctga cagctgaccc caccgagctg caccagttgc agccctcgcg tcgtttcctg     1140

gctctgctgc acctgctgca gctcggctac ctgtataggt gcctgcacgg aatgcggcag     1200

ggactgtcca tgtgctgcca ggaggtaccg tctgaatgtg acctggccta tgctgacttc     1260

ctctccctgg acatcagcat gctgcggctt tttgagagct tcttggaggc gaccccacag     1320

ctcacgctgg tgctggccat cgtgttgcag agtggaaatg ccgaatacta ccagtggttt     1380

ggcatcagct catcctttct gggcatctcg tgggcattgc tggactacca tcggtccttg     1440

cgcacctgcc tcccctccaa gccgcgcctg ggctggtgct cctctgcggt ctacttcctg     1500

tggaacctgc tgctgttggg gccccggatc tgtgccatcg ccacgttctc ggtcgtcttt     1560

ccctactgct tggccctgca tttcctcagc ctgtggctgg tgctgttgta ctgggtctgg     1620

cttcaagaca cgaagtttat gccaaactct aatggcgagt ggctataccg ggtgacggtg     1680

gcgctcatcc tttatttctc ctggttcaat gtgtctgggg gtcgcactcg aggccgggcc     1740

actatccacc tgggcttcat cctcagtgac agtgttctgc ttgtcaccac ctcctgggtg     1800

acagatagta cctggttgcc cggtggggtc ttattgtggg cggctttagg cggcgcctgc     1860

ttctccctgg gactggtttt gcgtatgatc tactacctcc ggctgcaccc tagctgcagc     1920

tgggaacccg actttgtgga tgggacccta agactcctcc ctcccgagcg tcctccaaag     1980

ctgatttata acaggcgtgc cactcggtta gcacagaact tctttgccaa gctcaaaacc     2040

caggccgccc tgccacaggc ggtacagctg aacggagtcc tctgaggcag ggtctgattc     2100

agccagtgag gaagatgagg agagtggggc cttgcaaggg acaagggggc caatcatgtg     2160

caagccagtt tttttcctct ccaaccgata gagcttccat tgccaaatct tcagttgtta     2220

ccactttcac ctctcacgtg attggtggcg tcctggttcc tggttcccta gcctgctcta     2280

gatgacagac tctgggggat gttctcgaga actcttccct aacctatccc atccattcac     2340

ttcccccaac aaatgcactg atgttctggg agcatcatcc tgacttctga actggctgcc     2400

accctagctt ctttccctgc ccacctggac aaatcctccg tagactcttg aagagcggag     2460

ggaggccaga gatgcccctc cagtgtcctg acgttcaggc tcttaggcca ccttacacca     2520

agtgccttat ggacctgtgg cctaggccat gtgatgccca ccaagtattt ttcattctcc     2580

tacctcagtc tgtgtgaaag aagaacatgt gtgcatgtgt ttaacagtat taaaacctca     2640

cgagagtctc caaaaaaaaa aaaaaaaaaa a                                    2671


<210> 14
<211> 399
<212> PRT
<213> Rattus norvegicus

<400> 14
Met Pro Leu Ser Val His Pro Gln Val Ala Leu Asp Val Val Ile Gly 
1               5                   10                  15      


Leu Val Ser Thr Leu Ser Phe Leu Leu Asp Leu Val Ala Asp Leu Trp 
            20                  25                  30          


Ala Val Val Gln Tyr Val Leu Val Gly Arg Tyr Leu Trp Ala Ala Leu 
        35                  40                  45              


Val Val Val Leu Leu Gly Gln Ala Ser Val Leu Leu Gln Leu Phe Ser 
    50                  55                  60                  


Trp Leu Trp Leu Thr Ala Asp Pro Thr Glu Leu His Gln Leu Gln Pro 
65                  70                  75                  80  


Ser Arg Arg Phe Leu Ala Leu Leu His Leu Leu Gln Leu Gly Tyr Leu 
                85                  90                  95      


Tyr Arg Cys Leu His Gly Met Arg Gln Gly Leu Ser Met Cys Cys Gln 
            100                 105                 110         


Glu Val Pro Ser Glu Cys Asp Leu Ala Tyr Ala Asp Phe Leu Ser Leu 
        115                 120                 125             


Asp Ile Ser Met Leu Arg Leu Phe Glu Ser Phe Leu Glu Ala Thr Pro 
    130                 135                 140                 


Gln Leu Thr Leu Val Leu Ala Ile Val Leu Gln Ser Gly Asn Ala Glu 
145                 150                 155                 160 


Tyr Tyr Gln Trp Phe Gly Ile Ser Ser Ser Phe Leu Gly Ile Ser Trp 
                165                 170                 175     


Ala Leu Leu Asp Tyr His Arg Ser Leu Arg Thr Cys Leu Pro Ser Lys 
            180                 185                 190         


Pro Arg Leu Gly Trp Cys Ser Ser Ala Val Tyr Phe Leu Trp Asn Leu 
        195                 200                 205             


Leu Leu Leu Gly Pro Arg Ile Cys Ala Ile Ala Thr Phe Ser Val Val 
    210                 215                 220                 


Phe Pro Tyr Cys Leu Ala Leu His Phe Leu Ser Leu Trp Leu Val Leu 
225                 230                 235                 240 


Leu Tyr Trp Val Trp Leu Gln Asp Thr Lys Phe Met Pro Asn Ser Asn 
                245                 250                 255     


Gly Glu Trp Leu Tyr Arg Val Thr Val Ala Leu Ile Leu Tyr Phe Ser 
            260                 265                 270         


Trp Phe Asn Val Ser Gly Gly Arg Thr Arg Gly Arg Ala Thr Ile His 
        275                 280                 285             


Leu Gly Phe Ile Leu Ser Asp Ser Val Leu Leu Val Thr Thr Ser Trp 
    290                 295                 300                 


Val Thr Asp Ser Thr Trp Leu Pro Gly Gly Val Leu Leu Trp Ala Ala 
305                 310                 315                 320 


Leu Gly Gly Ala Cys Phe Ser Leu Gly Leu Val Leu Arg Met Ile Tyr 
                325                 330                 335     


Tyr Leu Arg Leu His Pro Ser Cys Ser Trp Glu Pro Asp Phe Val Asp 
            340                 345                 350         


Gly Thr Leu Arg Leu Leu Pro Pro Glu Arg Pro Pro Lys Leu Ile Tyr 
        355                 360                 365             


Asn Arg Arg Ala Thr Arg Leu Ala Gln Asn Phe Phe Ala Lys Leu Lys 
    370                 375                 380                 


Thr Gln Ala Ala Leu Pro Gln Ala Val Gln Leu Asn Gly Val Leu 
385                 390                 395                 


<210> 15
<211> 3200
<212> DNA
<213> Homo sapiens

<400> 15
agaggtcacg tgacgccgcg cgggctgcgc gggcagtggt gggaaggctg gcgcgaggcg       60

tgaggtggcg tgaggcgaag ctggaatctg cctctgtcac gggggctggt gcctcacggg      120

tttgtgtcct agacaggcga gtggatccaa gtgggcgaga gacattttaa tctggaagag      180

tcttgtgatt tgggagacag tgaagaagaa gtaaaatatt cacaagatga agatttttcc      240

agaagggact ttgagtcaaa gatggctttt tatatttgac aagtcttgtc atctgtaatg      300

aagatcattg tgaaacagaa gattgattaa agccttgtaa cattggacct agattagaga      360

tttagaaaag aaagtcaaaa ttagtcactt tagtgttagt gttcccattt cataatattt      420

attctttctt ctaaatagat ttagggagta gaaattaaaa ttcaatgcta taccaaaggg      480

tatactaata tttgtttggc tttttttccc tttttgtgag ggagaaaaaa gtagataacg      540

aaaagctata gtcattcgta atgaaatata ctaaacagaa ttttatgatg tcagttcttg      600

gcattataat ctacgtaact gatttaattg tggacatatg ggtatctgtc agatttttcc      660

atgaaggaca gtatgttttt agtgctttag cgttaagctt tatgcttttt ggaacacttg      720

tggctcagtg ttttagttat tcttggttca aggctgattt aaagaaagca ggccaagaaa      780

gtcagcattg ttttcttcta cttcattgct tgcaaggagg agtttttaca aggtattggt      840

ttgccttaaa aaggggttac catgcagctt ttaaatatga cagcaatact agtaacttcg      900

tggaagaaca aattgatcta cataaagaag ttatagatag agtgactgat ttgagcatgc      960

tcagactatt tgagacctac ctggaaggct gcccacaact tattcttcaa ctctacattc     1020

ttctggagca tggacaagcg aatttcagtc agtatgcggc catcatggtc tcttgctgtg     1080

ctatttcttg gtcaactgtt gattatcaag tagctttaag aaaatccttg cctgacaaaa     1140

agcttcttaa tggattatgt cccaaaatca catatctctt ttacaagttg tttacattat     1200

tatcgtggat gctgagtgtt gtacttctac tattcttaaa tgttaagatt gctttatttc     1260

tgttgttatt tctttggttg ttaggtataa tatgggcatt taaaaacaac acccagtttt     1320

gtacttgtat aagtatggaa ttcttatata ggattgttgt tggattcatt cttatcttta     1380

cattttttaa tattaaggga cagaatacca agtgtccaat gtcttgttat tatattgtta     1440

gggtactggg cactttgggg atattgactg tattctgggt ttgccccctc actattttta     1500

atccagacta ttttatacct atcagtataa ctatagttct tactcttctt cttggaattc     1560

tttttcttat tgtttattat gggagttttc acccaaacag aagtgcagaa acaaaatgtg     1620

atgaaattga tggaaaacca gttctaagag aatgtagaat gagatatttc ctaatggaat     1680

aagctattca tttatgatat atattttctt atattttgtt tcattggtta gtaaagaaaa     1740

tgtgtgttat gtgggtgtgt tgtctcttat ttttgccacc tttaatttga aattagttca     1800

gtgaaatagg agatacatag tagtatttta tttttaaaat taatttctca tttggttttg     1860

aagatcttga gtactcagat atctttctac tgcctggtag agctgccatc ttgagcctga     1920

aatataagaa atggtctggt tttcataatg agaaggctgg aattgagctt ccctcccatt     1980

ttccttgttc ctgaactaat actactgtac ctgttatgga ggactgcaaa gggaagagaa     2040

aagcagaaca ctgtattatt ttttccttta ttgtcttcag tgcatatatt tgcagttggg     2100

gacaggttga gtagaggaaa agggaaagaa gggaaagcag aaaacaaatt tttagcatct     2160

gctgtgcttt catccatgaa atctccaatt cagtaagtgc aaaagagaat tggtgtgcat     2220

ctgagaggtc tgacatttca ttatttactt atttcctagc ttttctgaat taatgcactc     2280

ttaacatata attatattaa tcctatttgt gctagaatag ttgtatctaa atcatatttt     2340

aaaattattt ttatttttaa aaaattatgg taaaaacata taaaatttac catcttaatc     2400

actttgagtg tacagttcat cagtgttaac tgtattcacc ttgtgcaaca gatctcaagg     2460

actttttcac cttgtaaaac taagattctc tatttattga acaaatcccc atttcctcct     2520

tccccaagtc tctctcaact gaaattataa ttttttgttt ctatgagttt gaatacttta     2580

gataccttgt tgccatggtt tgaatgtgcc ccccagattt catgtgtgtg aaacttaatc     2640

tccaaatttg tatgttgatg gcatttggaa gtggtgggga ctttgtttat ttatttattt     2700

ttaatttttt aattttatat tattattatt attattatac tttaaggttt agggtacatg     2760

tgcacaatgt gcaggttagt tacatatgta tacatgtgcc atgctggtgt gctgcaccca     2820

ttaactcgtc atttatcatt aggtatatct cctaaagcta tccctccccc ctccccccac     2880

cccacaacag tccccagagt gtgatgatcc ccttcctgtg tccatgtgtt ctcattgttc     2940

agttcccacc tatgagtgag aatatgcagt gtttggtttt ttgttcttgc gatagtttac     3000

tgagaatgat gatttccagc ttcatccatg tccctacaaa ggacatgaac tcatcatttt     3060

ttatggctgc atagtattcc atggtgtata tgtgccacat tttcttaatc cagtctattg     3120

ttgttggaca tttgggttgg ttccaagtct ttgctattgt gaatagtgct gcaataaaca     3180

tacgtgtgca tgtgtcttta                                                 3200


<210> 16
<211> 3318
<212> DNA
<213> Homo sapiens

<400> 16
agaggtcacg tgacgccgcg cgggctgcgc gggcagtggt gggaaggctg gcgcgaggcg       60

tgaggtggcg tgaggcgaag ctggaatctg cctctgtcac gggggctggt gcctcacggg      120

tttgtgtcct agacaggcga gtggatccaa gtgggcgaga gacattttaa tctggaagag      180

tcttgtgatt tgggagacag tgaagaagaa gtaaaatatt cacaagatga agatttttcc      240

agaagggact ttgagtcaaa gatggctttt tatatttgac aagtcttgtc atctgtaatg      300

aagatcattg tgaaacagaa gattgattaa agccttgtaa cattggacct agattagaga      360

tttagaaaag aaagtcaaaa ttagtcactt tagtgttagt gttcccattt cataatattt      420

attctttctt ctaaatagat ttagggagta gaaattaaaa ttcaatgcta taccaaaggg      480

tatactaata tttgtttggc tttttttccc tttttgtgag ggagaaaaaa gtagataacg      540

aaaagctata gtcattcgta atgaaatata ctaaacagaa ttttatgatg tcagttcttg      600

gcattataat ctacgtaact gatttaattg tggacatatg ggtatctgtc agatttttcc      660

atgaaggaca gtatgttttt agtgctttag cgttaagctt tatgcttttt ggaacacttg      720

tggctcagtg ttttagttat tcttggttca aggctgattt aaagaaagca ggccaagaaa      780

gtcagcattg ttttcttcta cttcattgct tgcaaggagg agtttttaca agggccttgc      840

tctgtcaccc aggctggcct gcagtggcgc cttcccagct cattgcagcc tccacctcct      900

tggttcaaga gattctcctg catcagcttc ctgagtagct gggattacag gtattggttt      960

gccttaaaaa ggggttacca tgcagctttt aaatatgaca gcaatactag taacttcgtg     1020

gaagaacaaa ttgatctaca taaagaagtt atagatagag tgactgattt gagcatgctc     1080

agactatttg agacctacct ggaaggctgc ccacaactta ttcttcaact ctacattctt     1140

ctggagcatg gacaagcgaa tttcagtcag tatgcggcca tcatggtctc ttgctgtgct     1200

atttcttggt caactgttga ttatcaagta gctttaagaa aatccttgcc tgacaaaaag     1260

cttcttaatg gattatgtcc caaaatcaca tatctctttt acaagttgtt tacattatta     1320

tcgtggatgc tgagtgttgt acttctacta ttcttaaatg ttaagattgc tttatttctg     1380

ttgttatttc tttggttgtt aggtataata tgggcattta aaaacaacac ccagttttgt     1440

acttgtataa gtatggaatt cttatatagg attgttgttg gattcattct tatctttaca     1500

ttttttaata ttaagggaca gaataccaag tgtccaatgt cttgttatta tattgttagg     1560

gtactgggca ctttggggat attgactgta ttctgggttt gccccctcac tatttttaat     1620

ccagactatt ttatacctat cagtataact atagttctta ctcttcttct tggaattctt     1680

tttcttattg tttattatgg gagttttcac ccaaacagaa gtgcagaaac aaaatgtgat     1740

gaaattgatg gaaaaccagt tctaagagaa tgtagaatga gatatttcct aatggaataa     1800

gctattcatt tatgatatat attttcttat attttgtttc attggttagt aaagaaaatg     1860

tgtgttatgt gggtgtgttg tctcttattt ttgccacctt taatttgaaa ttagttcagt     1920

gaaataggag atacatagta gtattttatt tttaaaatta atttctcatt tggttttgaa     1980

gatcttgagt actcagatat ctttctactg cctggtagag ctgccatctt gagcctgaaa     2040

tataagaaat ggtctggttt tcataatgag aaggctggaa ttgagcttcc ctcccatttt     2100

ccttgttcct gaactaatac tactgtacct gttatggagg actgcaaagg gaagagaaaa     2160

gcagaacact gtattatttt ttcctttatt gtcttcagtg catatatttg cagttgggga     2220

caggttgagt agaggaaaag ggaaagaagg gaaagcagaa aacaaatttt tagcatctgc     2280

tgtgctttca tccatgaaat ctccaattca gtaagtgcaa aagagaattg gtgtgcatct     2340

gagaggtctg acatttcatt atttacttat ttcctagctt ttctgaatta atgcactctt     2400

aacatataat tatattaatc ctatttgtgc tagaatagtt gtatctaaat catattttaa     2460

aattattttt atttttaaaa aattatggta aaaacatata aaatttacca tcttaatcac     2520

tttgagtgta cagttcatca gtgttaactg tattcacctt gtgcaacaga tctcaaggac     2580

tttttcacct tgtaaaacta agattctcta tttattgaac aaatccccat ttcctccttc     2640

cccaagtctc tctcaactga aattataatt ttttgtttct atgagtttga atactttaga     2700

taccttgttg ccatggtttg aatgtgcccc ccagatttca tgtgtgtgaa acttaatctc     2760

caaatttgta tgttgatggc atttggaagt ggtggggact ttgtttattt atttattttt     2820

aattttttaa ttttatatta ttattattat tattatactt taaggtttag ggtacatgtg     2880

cacaatgtgc aggttagtta catatgtata catgtgccat gctggtgtgc tgcacccatt     2940

aactcgtcat ttatcattag gtatatctcc taaagctatc cctcccccct ccccccaccc     3000

cacaacagtc cccagagtgt gatgatcccc ttcctgtgtc catgtgttct cattgttcag     3060

ttcccaccta tgagtgagaa tatgcagtgt ttggtttttt gttcttgcga tagtttactg     3120

agaatgatga tttccagctt catccatgtc cctacaaagg acatgaactc atcatttttt     3180

atggctgcat agtattccat ggtgtatatg tgccacattt tcttaatcca gtctattgtt     3240

gttggacatt tgggttggtt ccaagtcttt gctattgtga atagtgctgc aataaacata     3300

cgtgtgcatg tgtcttta                                                   3318


<210> 17
<211> 3310
<212> DNA
<213> Homo sapiens

<400> 17
agaggtcacg tgacgccgcg cgggctgcgc gggcagtggt gggaaggctg gcgcgaggcg       60

tgaggtggcg tgaggcgaag ctggaatctg cctctgtcac gggggctggt gcctcacggg      120

tttgtgtcct agacaggcga gtggatccaa gtgggcgaga gacattttaa tctggaagag      180

tcttgtgatt tgggagacag tgaagaagaa gtaaaatatt cacaagatga agatttttcc      240

agaagggact ttgagtcaaa gatggctttt tatatttgac aagattcaaa atctagtgca      300

ttagactttt gaactagctg ttccttcaag ctggaaggct tttccatctc tatgcacatg      360

gccaatttca ctactcaaat gccaccttct cagtcttgtc atctgtaatg aagatcattg      420

tgaaacagaa gattgattaa agccttgtaa cattggacct agattagaga tttagaaaag      480

aaagtcaaaa ttagtcactt tagtgttagt gttcccattt cataatattt attctttctt      540

ctaaatagat ttagggagta gaaattaaaa ttcaatgcta taccaaaggg tatactaata      600

tttgtttggc tttttttccc tttttgtgag ggagaaaaaa gtagataacg aaaagctata      660

gtcattcgta atgaaatata ctaaacagaa ttttatgatg tcagttcttg gcattataat      720

ctacgtaact gatttaattg tggacatatg ggtatctgtc agatttttcc atgaaggaca      780

gtatgttttt agtgctttag cgttaagctt tatgcttttt ggaacacttg tggctcagtg      840

ttttagttat tcttggttca aggctgattt aaagaaagca ggccaagaaa gtcagcattg      900

ttttcttcta cttcattgct tgcaaggagg agtttttaca aggtattggt ttgccttaaa      960

aaggggttac catgcagctt ttaaatatga cagcaatact agtaacttcg tggaagaaca     1020

aattgatcta cataaagaag ttatagatag agtgactgat ttgagcatgc tcagactatt     1080

tgagacctac ctggaaggct gcccacaact tattcttcaa ctctacattc ttctggagca     1140

tggacaagcg aatttcagtc agtatgcggc catcatggtc tcttgctgtg ctatttcttg     1200

gtcaactgtt gattatcaag tagctttaag aaaatccttg cctgacaaaa agcttcttaa     1260

tggattatgt cccaaaatca catatctctt ttacaagttg tttacattat tatcgtggat     1320

gctgagtgtt gtacttctac tattcttaaa tgttaagatt gctttatttc tgttgttatt     1380

tctttggttg ttaggtataa tatgggcatt taaaaacaac acccagtttt gtacttgtat     1440

aagtatggaa ttcttatata ggattgttgt tggattcatt cttatcttta cattttttaa     1500

tattaaggga cagaatacca agtgtccaat gtcttgttat tatattgtta gggtactggg     1560

cactttgggg atattgactg tattctgggt ttgccccctc actattttta atccagacta     1620

ttttatacct atcagtataa ctatagttct tactcttctt cttggaattc tttttcttat     1680

tgtttattat gggagttttc acccaaacag aagtgcagaa acaaaatgtg atgaaattga     1740

tggaaaacca gttctaagag aatgtagaat gagatatttc ctaatggaat aagctattca     1800

tttatgatat atattttctt atattttgtt tcattggtta gtaaagaaaa tgtgtgttat     1860

gtgggtgtgt tgtctcttat ttttgccacc tttaatttga aattagttca gtgaaatagg     1920

agatacatag tagtatttta tttttaaaat taatttctca tttggttttg aagatcttga     1980

gtactcagat atctttctac tgcctggtag agctgccatc ttgagcctga aatataagaa     2040

atggtctggt tttcataatg agaaggctgg aattgagctt ccctcccatt ttccttgttc     2100

ctgaactaat actactgtac ctgttatgga ggactgcaaa gggaagagaa aagcagaaca     2160

ctgtattatt ttttccttta ttgtcttcag tgcatatatt tgcagttggg gacaggttga     2220

gtagaggaaa agggaaagaa gggaaagcag aaaacaaatt tttagcatct gctgtgcttt     2280

catccatgaa atctccaatt cagtaagtgc aaaagagaat tggtgtgcat ctgagaggtc     2340

tgacatttca ttatttactt atttcctagc ttttctgaat taatgcactc ttaacatata     2400

attatattaa tcctatttgt gctagaatag ttgtatctaa atcatatttt aaaattattt     2460

ttatttttaa aaaattatgg taaaaacata taaaatttac catcttaatc actttgagtg     2520

tacagttcat cagtgttaac tgtattcacc ttgtgcaaca gatctcaagg actttttcac     2580

cttgtaaaac taagattctc tatttattga acaaatcccc atttcctcct tccccaagtc     2640

tctctcaact gaaattataa ttttttgttt ctatgagttt gaatacttta gataccttgt     2700

tgccatggtt tgaatgtgcc ccccagattt catgtgtgtg aaacttaatc tccaaatttg     2760

tatgttgatg gcatttggaa gtggtgggga ctttgtttat ttatttattt ttaatttttt     2820

aattttatat tattattatt attattatac tttaaggttt agggtacatg tgcacaatgt     2880

gcaggttagt tacatatgta tacatgtgcc atgctggtgt gctgcaccca ttaactcgtc     2940

atttatcatt aggtatatct cctaaagcta tccctccccc ctccccccac cccacaacag     3000

tccccagagt gtgatgatcc ccttcctgtg tccatgtgtt ctcattgttc agttcccacc     3060

tatgagtgag aatatgcagt gtttggtttt ttgttcttgc gatagtttac tgagaatgat     3120

gatttccagc ttcatccatg tccctacaaa ggacatgaac tcatcatttt ttatggctgc     3180

atagtattcc atggtgtata tgtgccacat tttcttaatc cagtctattg ttgttggaca     3240

tttgggttgg ttccaagtct ttgctattgt gaatagtgct gcaataaaca tacgtgtgca     3300

tgtgtcttta                                                            3310


<210> 18
<211> 3136
<212> DNA
<213> Homo sapiens

<400> 18
agaggtcacg tgacgccgcg cgggctgcgc gggcagtggt gggaaggctg gcgcgaggcg       60

tgaggtggcg tgaggcgaag ctggaatctg cctctgtcac gggggctggt gcctcacggg      120

tttgtgtcct agacagtgaa gaagaagtaa aatattcaca agatgaagat ttttccagaa      180

gggactttga gtcaaagatg gctttttata tttgacaagt cttgtcatct gtaatgaaga      240

tcattgtgaa acagaagatt gattaaagcc ttgtaacatt ggacctagat tagagattta      300

gaaaagaaag tcaaaattag tcactttagt gttagtgttc ccatttcata atatttattc      360

tttcttctaa atagatttag ggagtagaaa ttaaaattca atgctatacc aaagggtata      420

ctaatatttg tttggctttt tttccctttt tgtgagggag aaaaaagtag ataacgaaaa      480

gctatagtca ttcgtaatga aatatactaa acagaatttt atgatgtcag ttcttggcat      540

tataatctac gtaactgatt taattgtgga catatgggta tctgtcagat ttttccatga      600

aggacagtat gtttttagtg ctttagcgtt aagctttatg ctttttggaa cacttgtggc      660

tcagtgtttt agttattctt ggttcaaggc tgatttaaag aaagcaggcc aagaaagtca      720

gcattgtttt cttctacttc attgcttgca aggaggagtt tttacaaggt attggtttgc      780

cttaaaaagg ggttaccatg cagcttttaa atatgacagc aatactagta acttcgtgga      840

agaacaaatt gatctacata aagaagttat agatagagtg actgatttga gcatgctcag      900

actatttgag acctacctgg aaggctgccc acaacttatt cttcaactct acattcttct      960

ggagcatgga caagcgaatt tcagtcagta tgcggccatc atggtctctt gctgtgctat     1020

ttcttggtca actgttgatt atcaagtagc tttaagaaaa tccttgcctg acaaaaagct     1080

tcttaatgga ttatgtccca aaatcacata tctcttttac aagttgttta cattattatc     1140

gtggatgctg agtgttgtac ttctactatt cttaaatgtt aagattgctt tatttctgtt     1200

gttatttctt tggttgttag gtataatatg ggcatttaaa aacaacaccc agttttgtac     1260

ttgtataagt atggaattct tatataggat tgttgttgga ttcattctta tctttacatt     1320

ttttaatatt aagggacaga ataccaagtg tccaatgtct tgttattata ttgttagggt     1380

actgggcact ttggggatat tgactgtatt ctgggtttgc cccctcacta tttttaatcc     1440

agactatttt atacctatca gtataactat agttcttact cttcttcttg gaattctttt     1500

tcttattgtt tattatggga gttttcaccc aaacagaagt gcagaaacaa aatgtgatga     1560

aattgatgga aaaccagttc taagagaatg tagaatgaga tatttcctaa tggaataagc     1620

tattcattta tgatatatat tttcttatat tttgtttcat tggttagtaa agaaaatgtg     1680

tgttatgtgg gtgtgttgtc tcttattttt gccaccttta atttgaaatt agttcagtga     1740

aataggagat acatagtagt attttatttt taaaattaat ttctcatttg gttttgaaga     1800

tcttgagtac tcagatatct ttctactgcc tggtagagct gccatcttga gcctgaaata     1860

taagaaatgg tctggttttc ataatgagaa ggctggaatt gagcttccct cccattttcc     1920

ttgttcctga actaatacta ctgtacctgt tatggaggac tgcaaaggga agagaaaagc     1980

agaacactgt attatttttt cctttattgt cttcagtgca tatatttgca gttggggaca     2040

ggttgagtag aggaaaaggg aaagaaggga aagcagaaaa caaattttta gcatctgctg     2100

tgctttcatc catgaaatct ccaattcagt aagtgcaaaa gagaattggt gtgcatctga     2160

gaggtctgac atttcattat ttacttattt cctagctttt ctgaattaat gcactcttaa     2220

catataatta tattaatcct atttgtgcta gaatagttgt atctaaatca tattttaaaa     2280

ttatttttat ttttaaaaaa ttatggtaaa aacatataaa atttaccatc ttaatcactt     2340

tgagtgtaca gttcatcagt gttaactgta ttcaccttgt gcaacagatc tcaaggactt     2400

tttcaccttg taaaactaag attctctatt tattgaacaa atccccattt cctccttccc     2460

caagtctctc tcaactgaaa ttataatttt ttgtttctat gagtttgaat actttagata     2520

ccttgttgcc atggtttgaa tgtgcccccc agatttcatg tgtgtgaaac ttaatctcca     2580

aatttgtatg ttgatggcat ttggaagtgg tggggacttt gtttatttat ttatttttaa     2640

ttttttaatt ttatattatt attattatta ttatacttta aggtttaggg tacatgtgca     2700

caatgtgcag gttagttaca tatgtataca tgtgccatgc tggtgtgctg cacccattaa     2760

ctcgtcattt atcattaggt atatctccta aagctatccc tcccccctcc ccccacccca     2820

caacagtccc cagagtgtga tgatcccctt cctgtgtcca tgtgttctca ttgttcagtt     2880

cccacctatg agtgagaata tgcagtgttt ggttttttgt tcttgcgata gtttactgag     2940

aatgatgatt tccagcttca tccatgtccc tacaaaggac atgaactcat cattttttat     3000

ggctgcatag tattccatgg tgtatatgtg ccacattttc ttaatccagt ctattgttgt     3060

tggacatttg ggttggttcc aagtctttgc tattgtgaat agtgctgcaa taaacatacg     3120

tgtgcatgtg tcttta                                                     3136


<210> 19
<211> 241
<212> PRT
<213> Homo sapiens

<400> 19
Met Leu Arg Leu Phe Glu Thr Tyr Leu Glu Gly Cys Pro Gln Leu Ile 
1               5                   10                  15      


Leu Gln Leu Tyr Ile Leu Leu Glu His Gly Gln Ala Asn Phe Ser Gln 
            20                  25                  30          


Tyr Ala Ala Ile Met Val Ser Cys Cys Ala Ile Ser Trp Ser Thr Val 
        35                  40                  45              


Asp Tyr Gln Val Ala Leu Arg Lys Ser Leu Pro Asp Lys Lys Leu Leu 
    50                  55                  60                  


Asn Gly Leu Cys Pro Lys Ile Thr Tyr Leu Phe Tyr Lys Leu Phe Thr 
65                  70                  75                  80  


Leu Leu Ser Trp Met Leu Ser Val Val Leu Leu Leu Phe Leu Asn Val 
                85                  90                  95      


Lys Ile Ala Leu Phe Leu Leu Leu Phe Leu Trp Leu Leu Gly Ile Ile 
            100                 105                 110         


Trp Ala Phe Lys Asn Asn Thr Gln Phe Cys Thr Cys Ile Ser Met Glu 
        115                 120                 125             


Phe Leu Tyr Arg Ile Val Val Gly Phe Ile Leu Ile Phe Thr Phe Phe 
    130                 135                 140                 


Asn Ile Lys Gly Gln Asn Thr Lys Cys Pro Met Ser Cys Tyr Tyr Ile 
145                 150                 155                 160 


Val Arg Val Leu Gly Thr Leu Gly Ile Leu Thr Val Phe Trp Val Cys 
                165                 170                 175     


Pro Leu Thr Ile Phe Asn Pro Asp Tyr Phe Ile Pro Ile Ser Ile Thr 
            180                 185                 190         


Ile Val Leu Thr Leu Leu Leu Gly Ile Leu Phe Leu Ile Val Tyr Tyr 
        195                 200                 205             


Gly Ser Phe His Pro Asn Arg Ser Ala Glu Thr Lys Cys Asp Glu Ile 
    210                 215                 220                 


Asp Gly Lys Pro Val Leu Arg Glu Cys Arg Met Arg Tyr Phe Leu Met 
225                 230                 235                 240 


Glu 
    


<210> 20
<211> 373
<212> PRT
<213> Homo sapiens

<400> 20
Met Lys Tyr Thr Lys Gln Asn Phe Met Met Ser Val Leu Gly Ile Ile 
1               5                   10                  15      


Ile Tyr Val Thr Asp Leu Ile Val Asp Ile Trp Val Ser Val Arg Phe 
            20                  25                  30          


Phe His Glu Gly Gln Tyr Val Phe Ser Ala Leu Ala Leu Ser Phe Met 
        35                  40                  45              


Leu Phe Gly Thr Leu Val Ala Gln Cys Phe Ser Tyr Ser Trp Phe Lys 
    50                  55                  60                  


Ala Asp Leu Lys Lys Ala Gly Gln Glu Ser Gln His Cys Phe Leu Leu 
65                  70                  75                  80  


Leu His Cys Leu Gln Gly Gly Val Phe Thr Arg Tyr Trp Phe Ala Leu 
                85                  90                  95      


Lys Arg Gly Tyr His Ala Ala Phe Lys Tyr Asp Ser Asn Thr Ser Asn 
            100                 105                 110         


Phe Val Glu Glu Gln Ile Asp Leu His Lys Glu Val Ile Asp Arg Val 
        115                 120                 125             


Thr Asp Leu Ser Met Leu Arg Leu Phe Glu Thr Tyr Leu Glu Gly Cys 
    130                 135                 140                 


Pro Gln Leu Ile Leu Gln Leu Tyr Ile Leu Leu Glu His Gly Gln Ala 
145                 150                 155                 160 


Asn Phe Ser Gln Tyr Ala Ala Ile Met Val Ser Cys Cys Ala Ile Ser 
                165                 170                 175     


Trp Ser Thr Val Asp Tyr Gln Val Ala Leu Arg Lys Ser Leu Pro Asp 
            180                 185                 190         


Lys Lys Leu Leu Asn Gly Leu Cys Pro Lys Ile Thr Tyr Leu Phe Tyr 
        195                 200                 205             


Lys Leu Phe Thr Leu Leu Ser Trp Met Leu Ser Val Val Leu Leu Leu 
    210                 215                 220                 


Phe Leu Asn Val Lys Ile Ala Leu Phe Leu Leu Leu Phe Leu Trp Leu 
225                 230                 235                 240 


Leu Gly Ile Ile Trp Ala Phe Lys Asn Asn Thr Gln Phe Cys Thr Cys 
                245                 250                 255     


Ile Ser Met Glu Phe Leu Tyr Arg Ile Val Val Gly Phe Ile Leu Ile 
            260                 265                 270         


Phe Thr Phe Phe Asn Ile Lys Gly Gln Asn Thr Lys Cys Pro Met Ser 
        275                 280                 285             


Cys Tyr Tyr Ile Val Arg Val Leu Gly Thr Leu Gly Ile Leu Thr Val 
    290                 295                 300                 


Phe Trp Val Cys Pro Leu Thr Ile Phe Asn Pro Asp Tyr Phe Ile Pro 
305                 310                 315                 320 


Ile Ser Ile Thr Ile Val Leu Thr Leu Leu Leu Gly Ile Leu Phe Leu 
                325                 330                 335     


Ile Val Tyr Tyr Gly Ser Phe His Pro Asn Arg Ser Ala Glu Thr Lys 
            340                 345                 350         


Cys Asp Glu Ile Asp Gly Lys Pro Val Leu Arg Glu Cys Arg Met Arg 
        355                 360                 365             


Tyr Phe Leu Met Glu 
    370             


<210> 21
<211> 1926
<212> DNA
<213> Mus musculus

<400> 21
gatcctaaag agttagacag tgaagaaata gaactcataa gctgaagatt tccaagaaga       60

gacattgagt taaagaaggc ttttatattt gtcacaaaca ttgttatctg taatgaagat      120

cacagcagag gcgaagatac agcaaggcct tcttgtacca cttgatctgg cgtagacatt      180

tttttttaaa ggaagttaaa gttattcact tttgttttag tgttccaatt tcataatatt      240

tatttattta tttttcgtac taggcactga atataggagt gtatgaatgt tagataaaca      300

ctccatcact gaactatatc accatattct tttcactagt tagactcagt gtataaatta      360

caattcaatg ctaacccaaa agatacacta gtatccattg tggcattttc ccctattttt      420

gtatctgaaa aggagtaact aggcaatagc cacagtcctt cataatgaaa tataccaagt      480

gtaattttat gatgtccgtt ttgggcatta taatctatgt aactgattta gttgcagaca      540

ttgtcctatc tgttaggtac ttccatgatg gacaatatgt tcttggtgtt ttaaccttga      600

gctttgtgct ttgtggaaca ctcatagtcc attgttttag ctactcatgg ttgaaggctg      660

acttagagaa agcaggacaa gaaaatgaac gttattttct tctacttcat tgcttgcaag      720

gaggagtttt cacaaggtat tggtttgcct tgagaacggg ttaccatgtg gttttcaaac      780

acagcgacag gaagagtaat tttatggagg agcaaacgga tcctcacaaa gaagcaatag      840

acatggccac cgacttgagc atgctcaggc tgtttgagac ctacctggaa ggctgcccgc      900

aactcattct ccagctctat gcctttctgg agtgtggcca ggcaaattta agtcagtgca      960

tggtcatcat ggtttcctgc tgtgctattt cttggtcaac tgttgactat caaatagctt     1020

taagaaaatc attgcccgat aaaaatcttc tccgaggact ctggcccaaa ctcatgtatc     1080

tcttttacaa gttgcttacc ttgttatcct ggatgctgag tgttgtactt ctgctgttcg     1140

tagatgtgag ggttgctttg cttctgctat tatttctttg gatcacaggc ttcatatggg     1200

catttataaa ccatactcag ttttgtaatt ctgtaagtat ggagttctta tataggattg     1260

tggttggatt catccttgtg tttacatttt ttaatatcaa ggggcagaat accaaatgcc     1320

caatgtcttg ttattatact gtaagagtgc taggcaccct gggaatcttg actgtattct     1380

ggatctaccc tctttctatc tttaactctg actattttat ccctattagt gccaccatag     1440

ttcttgctct tctccttggg attatttttc ttggtgttta ttatggaaat tttcacccaa     1500

atagaaatgt agaaccacaa cttgatgaaa ctgatggaaa agcacctcag agagattgta     1560

gaataagata ttttctaatg gactaacttg tgaattcatg agaaatattt tatttttttt     1620

gtttcattgc ctagtaaaaa aaatgtctgt catatgtatg tgttgttact tagtttatca     1680

cctctgtctg aaatgagtta tggcacatgg tgaatgagag catagtaata ttttatggtt     1740

taaaataatt tcttctttgt gttgctgagg atcaggcctg cacatgctat gtaaatattc     1800

taccactgag ttgcaccccc agccatctcg ctggttccaa aagtcttgag tgttgagata     1860

gttgctttct gtctgataga gctgccatgt tgttcctcaa gtggaataaa caatgtggtc     1920

ccataa                                                                1926


<210> 22
<211> 373
<212> PRT
<213> Mus musculus

<400> 22
Met Lys Tyr Thr Lys Cys Asn Phe Met Met Ser Val Leu Gly Ile Ile 
1               5                   10                  15      


Ile Tyr Val Thr Asp Leu Val Ala Asp Ile Val Leu Ser Val Arg Tyr 
            20                  25                  30          


Phe His Asp Gly Gln Tyr Val Leu Gly Val Leu Thr Leu Ser Phe Val 
        35                  40                  45              


Leu Cys Gly Thr Leu Ile Val His Cys Phe Ser Tyr Ser Trp Leu Lys 
    50                  55                  60                  


Ala Asp Leu Glu Lys Ala Gly Gln Glu Asn Glu Arg Tyr Phe Leu Leu 
65                  70                  75                  80  


Leu His Cys Leu Gln Gly Gly Val Phe Thr Arg Tyr Trp Phe Ala Leu 
                85                  90                  95      


Arg Thr Gly Tyr His Val Val Phe Lys His Ser Asp Arg Lys Ser Asn 
            100                 105                 110         


Phe Met Glu Glu Gln Thr Asp Pro His Lys Glu Ala Ile Asp Met Ala 
        115                 120                 125             


Thr Asp Leu Ser Met Leu Arg Leu Phe Glu Thr Tyr Leu Glu Gly Cys 
    130                 135                 140                 


Pro Gln Leu Ile Leu Gln Leu Tyr Ala Phe Leu Glu Cys Gly Gln Ala 
145                 150                 155                 160 


Asn Leu Ser Gln Cys Met Val Ile Met Val Ser Cys Cys Ala Ile Ser 
                165                 170                 175     


Trp Ser Thr Val Asp Tyr Gln Ile Ala Leu Arg Lys Ser Leu Pro Asp 
            180                 185                 190         


Lys Asn Leu Leu Arg Gly Leu Trp Pro Lys Leu Met Tyr Leu Phe Tyr 
        195                 200                 205             


Lys Leu Leu Thr Leu Leu Ser Trp Met Leu Ser Val Val Leu Leu Leu 
    210                 215                 220                 


Phe Val Asp Val Arg Val Ala Leu Leu Leu Leu Leu Phe Leu Trp Ile 
225                 230                 235                 240 


Thr Gly Phe Ile Trp Ala Phe Ile Asn His Thr Gln Phe Cys Asn Ser 
                245                 250                 255     


Val Ser Met Glu Phe Leu Tyr Arg Ile Val Val Gly Phe Ile Leu Val 
            260                 265                 270         


Phe Thr Phe Phe Asn Ile Lys Gly Gln Asn Thr Lys Cys Pro Met Ser 
        275                 280                 285             


Cys Tyr Tyr Thr Val Arg Val Leu Gly Thr Leu Gly Ile Leu Thr Val 
    290                 295                 300                 


Phe Trp Ile Tyr Pro Leu Ser Ile Phe Asn Ser Asp Tyr Phe Ile Pro 
305                 310                 315                 320 


Ile Ser Ala Thr Ile Val Leu Ala Leu Leu Leu Gly Ile Ile Phe Leu 
                325                 330                 335     


Gly Val Tyr Tyr Gly Asn Phe His Pro Asn Arg Asn Val Glu Pro Gln 
            340                 345                 350         


Leu Asp Glu Thr Asp Gly Lys Ala Pro Gln Arg Asp Cys Arg Ile Arg 
        355                 360                 365             


Tyr Phe Leu Met Asp 
    370             


<210> 23
<211> 1909
<212> DNA
<213> Rattus norvegicus

<400> 23
gatcctaaag tgttcgacag tgaagaaata aaactcatat gctgacgact tccaagaagg       60

gacattgaat taaagaaggc ttttttatat ttgtcacaaa cattggtatc cgtaatgaag      120

attgtgatgg aggagaagat acagcagggc ctccttgtgc tactgggtct ggagtagaga      180

ttttttaaaa aagaaagtta aagttattca tttttgtttt agtgctccga tttcatagta      240

tttatttatt tatttatttt tggtactagg gactgaatat aggaatttat aaatgttaga      300

taaacactct gtcactgaac tatatcacca tattcttttc tctgagtaga ctcagagagt      360

agaaattaca attcagtgct aacacaaaag atacactagt atccattgtg gcatttcccc      420

tgtttttgta tctgaaaaag agtagctagg caagagccac aggccttcat aatgaaatac      480

accatatgca attttatgat gtcagttttg ggcattataa tctatgtaac tgatttagtt      540

gcggacattg tcctaactgt taggtacttc tatgacggac aatatgtttt tggtgtttta      600

accttgagct ttgtgctttg tggaacactc atagtccatt gttttagcta ctcatggttg      660

aaggacgact taaagaaagc aggaggagaa aatgaacatt attttcttct gcttcattgc      720

ttgcaaggag gagttttcac aaggtattgg tttgtcctga gaacaggtta ccatgtggtt      780

ttcaaacaca gccacaggac aagtaatttt atggaggaac aaacagatcc tcacaaagaa      840

gcaatagaca tggccaccga cttgagcatg ctcagactgt ttgagaccta cctggagggc      900

tgcccacaac tcatccttca gctctatgcc tttctggagc gtggccaggc aaattttagt      960

caatacatgg tcatcatggt ttcctgctgt gctatttctt ggtcaactgt cgactatcaa     1020

atagctttaa gaaaatcatt gcctgataaa aatctcctca gaggattctg gcccaagctc     1080

acgtatctct tctacaagtt gtttaccttg ttatcctgga tgctgagtgt tgtacttctg     1140

ctctttgtgg atgtgaggac tgttctgctt ctgctcttat ttctgtggac tgtaggcttc     1200

atatgggcat ttataaatca cactcagttt tgcaattctc taagtatgga gttcttatac     1260

aggctggtgg ttggattcat ccttgtgttc acgtttttta atatcaaggg gcagaatacc     1320

aaatgtccaa tgtcttgcta ttacactgta agggtgcttg gcaccctggg aatcttgact     1380

gtgttctgga tttaccctct ctctattttt aactctgact attttatccc tatcagtgcc     1440

accatcgttc tctctcttct atttgggatt atttttcttg gtgtgtatta tggaacttat     1500

cacccaaata taaatgcagg gacacaacac gacgaacctg atggaaaagc acctcagaga     1560

gattgtagaa taagatattt tctaatggac taagttgtga atttatgaga aatgtctttt     1620

ttttttcatt gcctagtaaa gaaaatgtct gtcatatgta catgctgtta cttagtttgt     1680

cacttctgac ttgaaatgag ttatggtaca tggtgaatga gaagataata ttttaaggat     1740

taaaataatt tcttctttgt gttgccaagg attaggccct gtgcatgtta tcccaccact     1800

gagttgcaac cccagccatc tcgctggttt caaaagtctt gagtattgag gtagttacta     1860

ttccatcaag cgaataaaca gtgaggccca taaaaaaaaa aaaaaaaaa                 1909


<210> 24
<211> 373
<212> PRT
<213> Rattus norvegicus

<400> 24
Met Lys Tyr Thr Ile Cys Asn Phe Met Met Ser Val Leu Gly Ile Ile 
1               5                   10                  15      


Ile Tyr Val Thr Asp Leu Val Ala Asp Ile Val Leu Thr Val Arg Tyr 
            20                  25                  30          


Phe Tyr Asp Gly Gln Tyr Val Phe Gly Val Leu Thr Leu Ser Phe Val 
        35                  40                  45              


Leu Cys Gly Thr Leu Ile Val His Cys Phe Ser Tyr Ser Trp Leu Lys 
    50                  55                  60                  


Asp Asp Leu Lys Lys Ala Gly Gly Glu Asn Glu His Tyr Phe Leu Leu 
65                  70                  75                  80  


Leu His Cys Leu Gln Gly Gly Val Phe Thr Arg Tyr Trp Phe Val Leu 
                85                  90                  95      


Arg Thr Gly Tyr His Val Val Phe Lys His Ser His Arg Thr Ser Asn 
            100                 105                 110         


Phe Met Glu Glu Gln Thr Asp Pro His Lys Glu Ala Ile Asp Met Ala 
        115                 120                 125             


Thr Asp Leu Ser Met Leu Arg Leu Phe Glu Thr Tyr Leu Glu Gly Cys 
    130                 135                 140                 


Pro Gln Leu Ile Leu Gln Leu Tyr Ala Phe Leu Glu Arg Gly Gln Ala 
145                 150                 155                 160 


Asn Phe Ser Gln Tyr Met Val Ile Met Val Ser Cys Cys Ala Ile Ser 
                165                 170                 175     


Trp Ser Thr Val Asp Tyr Gln Ile Ala Leu Arg Lys Ser Leu Pro Asp 
            180                 185                 190         


Lys Asn Leu Leu Arg Gly Phe Trp Pro Lys Leu Thr Tyr Leu Phe Tyr 
        195                 200                 205             


Lys Leu Phe Thr Leu Leu Ser Trp Met Leu Ser Val Val Leu Leu Leu 
    210                 215                 220                 


Phe Val Asp Val Arg Thr Val Leu Leu Leu Leu Leu Phe Leu Trp Thr 
225                 230                 235                 240 


Val Gly Phe Ile Trp Ala Phe Ile Asn His Thr Gln Phe Cys Asn Ser 
                245                 250                 255     


Leu Ser Met Glu Phe Leu Tyr Arg Leu Val Val Gly Phe Ile Leu Val 
            260                 265                 270         


Phe Thr Phe Phe Asn Ile Lys Gly Gln Asn Thr Lys Cys Pro Met Ser 
        275                 280                 285             


Cys Tyr Tyr Thr Val Arg Val Leu Gly Thr Leu Gly Ile Leu Thr Val 
    290                 295                 300                 


Phe Trp Ile Tyr Pro Leu Ser Ile Phe Asn Ser Asp Tyr Phe Ile Pro 
305                 310                 315                 320 


Ile Ser Ala Thr Ile Val Leu Ser Leu Leu Phe Gly Ile Ile Phe Leu 
                325                 330                 335     


Gly Val Tyr Tyr Gly Thr Tyr His Pro Asn Ile Asn Ala Gly Thr Gln 
            340                 345                 350         


His Asp Glu Pro Asp Gly Lys Ala Pro Gln Arg Asp Cys Arg Ile Arg 
        355                 360                 365             


Tyr Phe Leu Met Asp 
    370             


<210> 25
<211> 20241
<212> DNA
<213> Homo sapiens

<400> 25
atcctctccc tcggagtcag ctggtggagg agaggaagcg ggaggaggga gcgcgcgcga       60

ggggaggaga ggaatgtgca ggtccgagga gcgccgcggc ggccgctgct gctcctgctg      120

ctggcggcgg cggcggctcg ggcggcagca gcgaagccgg gacggcgagg agcgcgggcg      180

gcgggcaggg gcgcgcgcgg ggcgccgcga gcagcttggc tccgcgcagg cagccaggcg      240

gcgctcctgc cggccccagg cgcgccgcta gcccggccca gcgcccagcc cggcgggcgg      300

cgggcggcgg cggacggcag gcgagccgac gcaggagcag gaggaggggg agccgcaccg      360

cctgggaggg aagccggggc gaggcgagga ggtggcggga ggaggagaca gcggggaaag      420

gtgtcagata aaggagggct ctcctccggt gtggaggcat catggccgct aaatcagacg      480

ggaggctgaa aatgaagaaa agcagcgacg tggcgttcac cccgctgcag aactcggacc      540

actcgggctc ggtgcaggga ttggctccag gcttgccgtc ggggtcggga gccgaggacg      600

aggaggcggc cgggggcggc tgctgcccgg acggcggcgg ctgctcgcgc tgctgctgct      660

gctgcgccgg gagtggcggc tccgcgggct cgggcggctc cggcggcgtc gccggcccgg      720

gcggcggcgg ggcgggctcg gctgcgctgt gcctgcgcct gggcagggag cagcggcgct      780

actcactgtg ggactgcctc tggatcctgg ccgccgtggc cgtgtacttc gcggacgtgg      840

gcacagacgt ctggctcgcc gtggactact acctgcgcgg ccagcgctgg tggttcgggc      900

tcacgctctt cttcgtggtg ctcggctctc tgtcggtgca agtgttcagc ttccgctggt      960

ttgtgcacga tttcagcacc gaggacagcg ccacggccgc tgctgcctcc agctgcccgc     1020

agcctggagc cgattgcaag acggtggtcg gcggtgggtc tgcagccggg gaaggcgagg     1080

ctcgtccttc cacgccgcaa aggcaagcat ctaacgccag caagagcaac atcgccgcgg     1140

ccaacagcgg cagcaacagc agcggggcta cccgggccag tggcaagcac aggtctgcgt     1200

cctgctcctt ctgcatctgg ctcctgcagt cactcatcca catcttgcag ctcgggcaaa     1260

tctggagata tttccacaca atatacttag gtattcgaag ccgacagagt ggggagaatg     1320

acagatggag gttttactgg aaaatggtat atgagtatgc ggatgtgagt atgctgcatt     1380

tgctagccac ctttctggaa agtgctccac agctggtcct gcagctctgc attatcgtac     1440

agactcatag cttacaggcc ctccaaggtt tcacagcggc agcttccctc gtgtccctgg     1500

cctgggcctt ggcctcctac cagaaggccc tccgggactc tcgagatgac aagaagccca     1560

tcagctacat ggccgtcatc atccagttct gctggcactt cttcaccatc gccgccaggg     1620

tcatcacgtt tgccctcttt gcctcggttt tccagctgta ctttgggatc ttcatcgtcc     1680

ttcactggtg catcatgacc ttctggatcg tccactgtga gacagaattc tgtatcacca     1740

aatgggaaga gattgtgttc gacatggtgg tggggattat ctatatcttc agttggttca     1800

atgtcaagga aggcaggaca cgctgcaggc tattcattta ctattttgtg atccttttgg     1860

aaaatacagc cttgagtgcc ctctggtacc tctacaaggc tccccagatt gcagacgcat     1920

ttgccattcc agcgctgtgt gtggtgttca gcagcttttt aactggcgtt gtttttatgc     1980

tgatgtatta tgccttcttt catcccaatg gacccagatt cgggcagtca ccaagttgtg     2040

cttgtgagga cccagccgct gccttcactt tgcccccaga cgtggccaca agcaccctac     2100

ggtccatctc caacaaccgc agtgttgtca gcgaccgcga tcagaaattc gcagagcggg     2160

atgggtgtgt acctgtcttt caagtgaggc ccactgcccc atccacccca tcatctcgcc     2220

caccacggat tgaagaatca gtcattaaaa ttgacttgtt caggaatagg tacccagcat     2280

gggagagaca tgttttggac cgaagcctcc gaaaggctat tttagctttt gaatgttccc     2340

catctcctcc aaggctgcag tacaaagatg atgcccttat tcaggagcgg ttggagtacg     2400

aaaccacttt ataaagcaaa aggagttgca ggacccacaa catccagatg aaggggtgac     2460

agcagggctg tggccataat gacacttcat cctagagcag ggcagtgagc cgtgaagttc     2520

ctagtgggac cgtcatcacc attatcattt gatcctgtcg gctgggggcg gctggtctcc     2580

ttccaaagca gctgcacccg agagtctctg actccacctg aaagaatgac gctggcttaa     2640

taggactctc cattgctacc aaactcctcc tgcacggtct tgggtgcacc caccagaggg     2700

tactactatt atggaaaaat tttgcctcca atcattaggg tgtcttgatg gcgttaactg     2760

atctttccat aaaaatagat tcagtcatac acacatacac acactaacac acataagtta     2820

caccagtcct ctgtcaaaaa agcttaggtg acttttcttg atgcaaagct ctgattccca     2880

caggaatata aaaacaaaga aagagggaaa catccctcga gaaaaaaaat agtattgctt     2940

agaaaagaaa ccattttctc atttggaaat ccataccatg tgtgaaaatc ctatccaacg     3000

gacagcaaac ccaaatgttg tctacacatg tgttagcatt gatggagtgg ttcattttct     3060

acacatttca ggatttgttt tatattttaa attttcagtt gcgaacatcc tttttgacag     3120

aaatcctatg cagcccatgt acggctttca acaagaccaa ggagctcaat aacttcatga     3180

tgtaaattaa atagtaatca tgattcagta ttcaattgca aaaatgtaac aggtacacaa     3240

agaggaagtg gggaaaaagg caaaatgaga gtctgattcc caggcatgtg cagcgcccat     3300

tgggacataa cggcagtgcg gcgcgagcca gaggaatggg ctggaaccgg atctgtttcc     3360

agacgcagaa tgagtggctc tgtgtgacca taggcagatg ctgactctgg aagactccgt     3420

gccactcctt tctagtgcca aacaccatcc aaccacagga ctgacgtgga agccccaaac     3480

aactgagaat gagtggcatg agccccctaa aagcaggcga gagaacgagc aatcaagttc     3540

tccactgtgt acagactttt cctcccccca atccaaggtc aaagtgatgt gtcttttaga     3600

ggctttggga cactttttag taagtatgag cagacaaatg caatgaatat gctatgaaaa     3660

aacccttctg aactgagaga gggcttatca ctatatccag ctaagatttg tatttgaatc     3720

atctgtaaag tcgcactctt acaacaagct tctgggtttt aaatacctcc gtacagcaag     3780

taaacgttcc ccgctttctg ttctcagtgt cctcggtcat ggtgcttttc gttgcattaa     3840

aagtgccggt caaactttga tagtattttt ttatagttgg tgcagagtgg aataactcat     3900

ggattatttc aatatttttg taataaaaaa tatagggtat acacataggc atcatcacat     3960

tttttataga cctggaatcg tttaaaatac tttaagcatc ataattactt gggatgtcag     4020

aaactggtcc acaaattcca tcagcctgcc tcagcagatt gaaaacattt gtctcttgca     4080

agatcaccct actttgcaag ttggtgcccc caggaacctg gccaggggtg ctatcagaat     4140

atcaggtgaa gagagaatca gcttaaatag aaagggcttg tcaagactgg ccaatgtttc     4200

ccaggaaatc aaagatgtaa atgattactt tcatccatcc attataacaa acctgaccac     4260

agtggaagct gtcttaaact tccttccctg gttttatatt aacccaactg atagattaag     4320

tattagtcaa accactaaaa aagaaaaaga aaaaagttta acttaattat tcggttattt     4380

ggatctaatt cacacaaagt agtccagttc tctagccacc acctgtaatg ggtgtgtcat     4440

ccagagactg tgtccccacg atgacatcca caggaagtaa cagagggctc aacctaggac     4500

ttcttttggt acaaagcccc aaatcaattt ttttaaaaaa tagacaattt ttataagtag     4560

acatacttcc tagtactcca tgatttgatc ctccaagcaa gatttccact aaaaaatact     4620

aatcttttgt tgggatgtgg aaagattacc tagtcaccag taaaggccca ggaaaaggct     4680

cttcttgtca gcacatggtg aaaacattcc atccccactg gagaaggaaa aaacgatttt     4740

ggcaaattct tcacttttgt gcagaacctt gagttattag cttcattgtt tccaagacaa     4800

cttttaactg atgatctttg gaaattgagt ttctcagttg aactgtacct ttgattctat     4860

gagtaaatca cagattacag tctaatagag tcaatcaatc aacacaaacc caacaggccc     4920

catcatgctt caatcatgta agttctaagt tatttctcaa cttgatccct cattcaacat     4980

gttaagagtc agaatgaata ctatgtcaat gaaaaatgat gtactgtgct ttgacttgga     5040

ggtgagattg gcagtcagga gaatgtaagg aggttgaatt tttcagtgat ttcccaaata     5100

ctgtaaatac tctgttatcc gacatatttg gagattatga tgttttaatt aggcatgaat     5160

tcttgttaag gaaagaacat atccatgatg tgatgaatta caacctttca aaagattaca     5220

agagcaaaac aagagataaa tcatgattta gccttgcttc catgattcag gaagcactac     5280

actgccatca gactgttgtg gtaataacaa cttttacttg ttttctagat gcacagataa     5340

cagagagttt aaagtattca gatttaaaga gacatcatca gtgtacaaag aaacaaagtt     5400

tcatttttgt atttatattt taattctaac atttcctttt caatctgcca ttaaaccctc     5460

cgcagacagt aactggagaa tcccaaagga aaaaattgga aatgctgggt tccttatctg     5520

caggctcctt tctgtgtctg agtccacttt gattccattt aagagggaga tctgctctta     5580

ctcacttttt gcataggatc aggaaatttt ctaaaggaac aacattgtaa tttgttttac     5640

ttttaaactt gcatttctaa atatgaaacc atgtttaatg aatatatata atgtgtgtgt     5700

gtgtatctta accatagtga cactttaagt gtttgtgtga aagaaaagga aataattttt     5760

ccatgtaagt caaagtttag tctcccaaaa tgactatgtc ctttaaatcc tctttgctta     5820

tttacttaac tacatactgt ctagttcaat agcactgact ttgcagacac ttagttacta     5880

ctcatttgtg ataaacgctg ttaacccaac aaatataata aattctctta ctgacatggc     5940

aagaatatat aattcaagta ttagcaaaag ataatctgag gataaaagta aaatgaagta     6000

ttttatggtt aatttctaaa tgcccaattt attttgctct atgagtaaag gaagtgattg     6060

cacagaacaa ttaaaagtga atgagaatag ttgaaaactc aatggctgtt ttttaaaaat     6120

gatatgtgcc ttttaagtgt gtttgtgtac atacatatat gtatatatac gtacctatat     6180

atgtatgtac acacacacac acacacactt tccaactaaa gtaacagaga tgaaaaggat     6240

aaagtatata ctgcttttga atgtatataa agtggtatgt tatgcatata aattgtacat     6300

aaacttttta gaaaagaagc attttcctgc tcctttttca aaaccaaccc aagcttacag     6360

tccatctata agaccaacac acttacgaac ttcagttgga aatacctaaa tataattcag     6420

cacttcttag ctcgaatgag ttttatcact tcttaaggat ctcatctttt aaacagctga     6480

ataaaatagt tctgtgtcac ttcaaagttt ctttctctga acagattgaa ttgagcaaag     6540

agaacctctt ctgtccttac caggattgtg taaggttaca catttgcttt taaatatacc     6600

aaatgccgtt gattggaaac aagttctgac acaatgttta gacaagaatc cagagatttt     6660

ttctaatgaa ccattttcta gactaaatat atgctccctt gcattttcca catatctttg     6720

ccattagcca ttgctgtttc tatataaagc ttggatgaga tgcctgcatt tttatgtgct     6780

aaggagaatt ccttaaagcc tttttaaaaa tagctcatac tgtcattcag attatagctc     6840

agaggatggt tgaagcgcat ggtgaaaaca caggaggact ggggtggtca ttcctataat     6900

ttcagtgaca gatgcagatc aacgttcctt tgtctcggca atccaatgtc atttttgaaa     6960

acaatcaaaa agatcgcttg tgtcagcttc tgactcataa cactcctccc acctgatgct     7020

ccagtgtttc aaaatggcca aggatgggcg attccgctct atcccccatt tctgagactc     7080

ttgtctggac ctgtaacagg ccgtgaaatg ccctgagcat tcgagtggca tcccttctcc     7140

tcacataggc acctgggtgg cagcatcaga ccactgaagt tgttgtgttg acatatgtct     7200

tatctagttg ctgtcctaaa aatgggcatg tggcaagact ctcaatctac agcctcgaca     7260

gtatcattac tcattctaaa gtaaaactgc agaatatggg tggaattgta taaaaacata     7320

atgagccatt taattttgct aattgaagca attagtctaa catgcaagca gcctgctctc     7380

acagcagaga gccacatgga agaagtgcca aatagccatt tgcatttata tatatatatt     7440

gcaggcagtg acctggcccc caaatgtaaa gcttttgtca accttgaggc ctatattctg     7500

ctaaacaaga gatgacttaa tgtccttgaa atattttcgt aatatactga cagcctaatg     7560

tcagaaacga gctgcctaaa tcaagttttg cttttggtta tttcacttcc ccatagactt     7620

tcttatggtt ccatctccca cattgagagt agctcaccac gatggatggt ttactgcgca     7680

cctagtgctg gactaagagc tgtatctatg tggtttcatt tagtcctcac tgccatctgt     7740

gagttaagca tcatttacag atgacaaaat ctgtaaatgg cttagagatg tcaagcaatt     7800

tgcccaaagg tcccacagct aggaaacagt ggggctgagg gttgagcaca gctttcaaca     7860

actgcgactt ctgggagccc agtgactctt cccacaaaat ctagtcctga tttggcaagt     7920

cttcagaaga aacagaatca tggtctgatg atcaaatttt tccaagaaaa ttttatttaa     7980

aagtcaaaga tgtccttcaa aatgaacagt taaaaatgta aaagtcgatg taaaatggaa     8040

gtctctatca cctgtaacta aattttacct taactctaac tcatagtagg cagataaatg     8100

ctattcttcc attccaggca actgtccccc tcctatggct ccactatgta ttcaattaag     8160

tgataaatat aaattaacct gatgccatgt ctcttgtatt ttatatgtgt atgctgtttt     8220

catccaatta agcagactga aaaaaaacta aaccccatta cttactttgg cattttgaca     8280

agatagagag agaggaaaag aaagagggag ggagagaggg agggaaggaa gaaggaagga     8340

aggaaggaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggagatt     8400

taacaagtct ttgaagtgat attttcaaat tataaggtaa ttctgtttca ctgccataat     8460

ttttccctaa attttattta atatcttgca ggtcacaaac tttaatattt aagaggatta     8520

ttaaaccact agcttgaaca atcatataag tctaggaacc ttattttagt gttagatgcc     8580

aataatactg caagtgtcaa ccaaatattt gttgaattga attataaaat aattgatgtg     8640

ttctttccct tctcacttta gatatagcat gtctgaaggt ctgcaagatg acagagttgt     8700

aacccattca atgatattgt tgcctagtaa gctgtgtgtg tgttgtttga actgatacta     8760

aaaaggtagc tgataataaa ccaaaaattt tctcaaccct ggtgtttatt tttaaaaaat     8820

cttcaatgat caatatgaat gtagtgtatt aaaatacaag taactatctt cctactttga     8880

tttaagagat ctttatgaat ttatataaaa ttagaagtca ctgattttta taggaaatag     8940

catgtaaaat aaatctaagt attgctttat cactttattt tatagatgag acaactgaga     9000

tccaaaaaga acaggtaatt tttgtgatca ggattacaca atacactttt ttttttccct     9060

gagtcattta ttcaacaagt ttgacctcta caactcattt ggctaggcaa tgcacagtca     9120

agcacaaaag gaaagttgca ctggaatagc tcatagtctg gctattagca gcacaatcat     9180

agttttctga cgccagctct tactcttttc tactctacca cactgtttct tctcttctca     9240

atatctatat ttaattccat attgaagcaa gaaagaaaca cagcttttct aagactatgc     9300

agtcatgtgt cacttaagga tggggatatg ttctgagata tgcatcgtca ggcaattttg     9360

tcattgtgtg atggagtgtg cttacacaag cttagatggt agagcctacc atgctcctag     9420

gctatatggt agagcctatt gtccctaggc tacaaacctg tacagcatgc tactgtaccg     9480

aatactgtag gcaactgtaa caccatggta agtacttgtg tatttaaata tagaaaagtt     9540

aacagtaaaa aatatagtat tattgtctta tgggatcgct gtcatatgtg cagtctatta     9600

ttgaccaaaa tgccattgtg tggcatgtga gccttacaat atacaattaa catatgaaat     9660

aatgatgatg aacataaagt aacaatacaa atacaaaaaa aaaactagat gactgcttat     9720

aaagagaaaa gtaattttat aatttgttta tatgactctc caacactaga tatttttaaa     9780

ttgatatcac aacacacaaa aaaattgaaa tactctcttg gtgcatagta tttgattgaa     9840

aacaatcatt tttggataaa ctttgaagcg attcttgaga acttatttca agaaaaggca     9900

tgaaattagg gagactccaa agtgaagagt tttccaatag gtgacttctc tgatttttca     9960

agaaagcatt cttcactaac tgtatttctc cagcatactg gttatttagg aataacaaat    10020

ttctggacat aaacatgagc tgtttctcta aagcctttcc tccaatgccc agaagagcag    10080

cactgtgctg cgtgacaatt tcaggagtca ggagtcagga gtcaggacag tcagccccag    10140

cttcctgggg aaacccacac tggctttgga cccgattgca ttctctcctg agtgattggc    10200

ttcccacata tataagcagc agattgttaa agatcactat taacttgtat aactaatttt    10260

ccttatgtga aataattctg gtcagggaat atataaaccc attggccctc taaggagtag    10320

aagaaaagag agaagaaagt atattaactt ttatgagtac agaataattc aagttcctta    10380

gcgagtcaca ttatgcatta ataaaagagt tgacctaata aatgttacaa ggtaccatga    10440

tctctaggtt catgccacca ttaccacatt ccttactaca attattgcta ttttagtcat    10500

tggaccagac aaaatgaagc atataattac tgatataata tttgctaagc aaaaatcttg    10560

tttaacgaaa aaaatcaata ccaaaactaa ttaatcaaaa tattaagcaa atattaccag    10620

cacagtactg acacaaaatt ttctcttgtg ctagtaattg aagtatgtca tctaccctgt    10680

tattagaatt tcagaaaata ggccgggcgc agtggctcac gcctgtaatc ccaacacttt    10740

gggaggctga ggcgggcgga tcacaaggtc aggagatcga gaccatcctg gctaacacag    10800

tgaaaccccc atctctacta aaactacaaa aaaattagcc aggcatggtg gcgggcgcct    10860

gtggtcccag ctactcggga ggctgaggca ggagaatggc atgaacccag gaggcagagc    10920

ttgcagtgag ccaagatcgt gccactgcac tccagcctgg gtgacagagc aagactccgt    10980

ctcaaaaaaa aaaaaaaaaa aaaaaaagaa tttcagaaaa tataaagttt tatgttttta    11040

ttatatttcc atctaccaaa ttgttgacct tctcctcctc tccattgctt aatttatatt    11100

aaaacagatt taatcaaatt attacttaag tactacaaat gttatcagat ggagatgtgg    11160

ttaagctaat ttaatttacc tattctagtg gcattctggt atggagctgt atcaaatcaa    11220

cacttttaat tatttcacat taattcatca agaagttcca aaacactact aaatgtgttg    11280

aaaatatagt ttgagtttct atgattgtaa tcaaaattcc tattttgatc gcacaccagt    11340

agaacgcatc ttaacaccag cattgccatt gtgagtctag aaaatgagca ctttgtgtgt    11400

tgagcgctgt tgcattcact tagcaattaa cctttgacct gtggttttct gctgagcccc    11460

ttgtgatttt ttttattcta ttcaaattgg gagcaataac acaccttaac ataaccaaaa    11520

aaaggagacc tgtcagctag tgaaagaatt gtcattttat atcattcttt caaaaaatta    11580

aaatattcaa cttcccttat taacctttct aatgcattgt acataaaaga ggaaatggat    11640

ttctgaaata tattttgaaa gcctggggtg aaacattttc cacggtctga atcggaagct    11700

tggggctctg tggaaagatg taaatccctc ctgctgtaag aggagggaag gcagcagtga    11760

gctgtcactc agaaatacag tcaccactgt cacaaagctg cctattgctg atgctatcga    11820

ttcccttctt tttctacaga aacatcttgg agcttgtcaa gctttactgg aggtgatttg    11880

cagttaatta attcaacaga cactttaatc ttgcaaattc ttgacttgta atattgtaac    11940

caagctcctg caagggaaca ttaatcagtt agtgaaaaag gagcacttcc gttcagccgt    12000

agtaccatga cgtgcacagg cctgaagaga aatacctctg tgaagtggag cgctagtgaa    12060

ttcctgctac ctgcttctta tggctcacgc tatgaatatt cacctgcttc atttgttttt    12120

tccagtaaac gctgttttga aaaaaaagaa aaatattccc gggggcttgc atagctcaga    12180

gaacggagta ctgggtcgtg gagacttgct ttaaatggat tcaaatccac atgtttggaa    12240

atgaaaataa tgcactgtca tctgttgaat aattgatctg tctgagtaca gttgctgctt    12300

ttatttcatt tcttgagact accattgtca gcattgtaat aaccaattta taaaaattga    12360

gtttttattc agtttcagag gtaaaatctg catgggtgca gctactgaat aatttgattc    12420

ctgccttctt aggtggtgac attagcagtt ccaaaccgag atccatttct atgtggaatt    12480

ggctatcctg ttgcttctca ggccctgcaa aaccttggtt acgagctcaa agatcacgaa    12540

tctgatattc tttttttttt tttttttttt ttttttttga gacagagtct cgctctgtcg    12600

caggggctgg agtgcagtgg cacaatctcg gctcactgca agctctgcct cccaggttca    12660

caccatcctt ctgcctcagc cttctgagta ggtgggacta caggcgcctg tcaccacgcc    12720

cggctaattt ttttgtattt tttagtagag atggggtttc accgtgttag ccagaatggt    12780

ctcgatctcc tgacctcgtg atctgccctc cttggcctcc caaagtgctg ggattacagg    12840

cgtgagccac cacacccggc cccgatattc ttaatgacta aattttcaca tagaggtaaa    12900

cagatcatct cttaatttaa tacatggttc tttctccctt gcttctgggt tttgtttttt    12960

ttttttcaaa gaaagatttg agctacgaga taagaatgaa gttaccagaa gttatcaggt    13020

catagtttca gagtatgcaa gagagtcggg ccttcatatg ttcttgtaaa gttttctgtc    13080

taatcttttg gtataacaat tttaggagtt caccctagat gaaagagtgg aagtcatcag    13140

atttgtcaat aagcagtcta gaggaaaaat gagaagagga agaagcaggg attctttttc    13200

ttgtgttttg aagatgtttc tcctcccaaa gctatcacct tggtagttat caccaagatg    13260

tataatagca agcactactg aatgatcttc ccagttatca gcactagcat cacggcgagt    13320

cagttttcag aactagctct tggcgcaagc cctgaaataa aatggggaca aaaagtggtc    13380

taccaccatg tgacttattt tctttttttt tttaatttta ttattattat actttaagtt    13440

ttagggtaca tgtgcacaac gtgcaggttt gttacatatg tatacatgtg ccatgttggt    13500

gtgctgtacc tattaactcg tcatttagca tcaggtatat ctcctaatgc tatccctccc    13560

ccctcccccc accccacaac actccccggt gtgtgatgtt ccccttcctg tgcacgtgac    13620

ttattttcaa ttgcccagca atgaaaacta acaagttaaa gaaaatgttc attttctgaa    13680

ccccagagcc cacataggta caaagatact ctgtaatgta caatgaggtg gccaatcgtg    13740

ggaatatagg agcaataaat agtcctctta agcaaggttc atgggtaaga gttactctag    13800

caggattggg tgttgggtca gagggtatct attaatgtag aggcccaagt atggtgatga    13860

agagaaaacc tgtcagtggc tcatccatag tatttgcctt ttcacagagc agagaagttc    13920

aaaatagtca cagccagtcc ataactataa caacagacat gtccactttg gaaaggctag    13980

ggcctgacga aagtgggaaa acagagatgt cagtggtgtc atgtctaaga gtgactctgt    14040

cattagggga acccaccccc tgtgatagtt ctccttgacc actggtccct atgggctctg    14100

caggagagct tctcgtgggt tctaagataa ggtattccaa ggtattgtaa gttacccttg    14160

tttgtagaac atgaaccact taaccatccc tccttttaac agcaatgaga ttcagggtta    14220

ccatggcctt actcatcttc ccattgtaaa tatatcacaa tgtcacaaga gcctctgtgt    14280

ccaaacacac taaactgggt ttacaagcat tagaatcttt cactcatatt gtgaatctca    14340

attctgccag tcacctagtc tgtgtatctg ttcccaaact ggaaaaaata attcttgaga    14400

gaataatttt cagaataatg gaggtggaaa gaaatgaaca gttaagcaat ttttcaacat    14460

agacaaaacc actggaccat tgatagccct caagctctga ttcttcctcc tgactaagtt    14520

tcttttcttt ggggggcttt caacatctga attttccaga tgattgcgga accatcgtca    14580

ctaaaccaaa gtagacaagg agttattaaa aaataaagac tgtccacatg actgcaaata    14640

tcctgatgaa aagtggccaa gtagatcact caagtggtaa atttggtctt catgatatca    14700

aacatacgga tatttggaaa agtcgagatg tttgaatcat acagttttcc gtctgggtgt    14760

ctggtgtttc tggatagaca gactgctccg gtgttgtaag taatggaatt gaactttctt    14820

gcgccgtaag caattgctgg tcatattctg ctgctaaaag tctctttgtt gtgccaagag    14880

aaataatgca gaacaaatgt tatttaattt ttatttactt tcagcaaaca catgaatgaa    14940

agaggtcagg taggctgtcc tgggcattct gggcctggct gcggcacacc ctccttcact    15000

tggcccctgc caggcaagaa actttctatt cagtctttgc tatctttcat aaattgtatc    15060

attgctcttc tgctgttcat atcatcttag ttattcacaa agtctacttg ataaaatggc    15120

tcaagggaaa tacaagtttc ttaagttttt attcttcaaa tagaagtttt aattttaagc    15180

attccttatg atatttttta agcctaaaaa ccattcaaat tgcttgacaa aattatttca    15240

tggtgaattt tataaggttg atagaagtaa aagctatttt tcccaaaaca aacaaaatac    15300

catacatagt tttttgggtt tggtttgttg atgtcatgcc aatttccaag caccaactgg    15360

ttaccacaaa catgggaata tttagtgata tctttgtagt catcgttaaa attcctggga    15420

aaaaaagaaa aagtttacgt caaaggaaaa ttcacctccc acaaggaaag tctgagatgt    15480

tcatcctgac atttgcgttc ctgattattt gtggacattt cttcattgtg actgtaggaa    15540

gctgagcttg tttctcctaa tttgacactg ggttggtgag cattgtctca aattttgtgc    15600

ttgcctcatt tatggtcctg aagcttagca gaaaaacaga caagctattc agaccagttt    15660

tctttaagag cacttatgtt gcagaacatg atacaaatga ttcaccgtga gcaggcacac    15720

agagtacgga aaggtattca actatgcaaa gatattgagg ggatttccag agaaaactta    15780

aatgttttga agatttgtag gtagggtttt gattgtgtca cattctacac tcagtgccaa    15840

gttagaatgt ctttatgggg aaggcaataa agttacttgt tgggtccttc cttcccttac    15900

aaacagaatg tttttatgaa atcaaatgga tcctccactt tgtgtagtaa ggacccccca    15960

ggccccacaa catcatcact gtgagtccta tcgcagatgt gtgtaccagc ccaattcagt    16020

tttgcttttc tttttcccta agatttttac ttcaccaaat cccatttcaa atctttttac    16080

cttcatgtta ccaacaggat gtttagttga atcagcaaca aagacgtgac aacctattgt    16140

cctccacaaa agcatgagtc attttattca gtgatctttg gtagtacgat aatcaatgga    16200

atttatggtg tcgtagaaaa ccaaaaatcc atgttgaata tagtgactgt cttaaatata    16260

cttaaatatg ttattctaca aaacaatatc cttttacact atgggatgga ttcctttctg    16320

gatgcaggga tgggagggtc tatgggtcag tgactgggac aaaggaactg ggaatctctg    16380

cacaactgag ccctaatccc tggtccatct ctccagcctc agaaactcac cctcagcctc    16440

attttcccca tatgcaaaag agagatattt atttacctac ctcatagggg tgttgtggag    16500

attagctaga tttgctaaag tgcttgtagg ttagaaagtg ctgtcattcc tgagaactgg    16560

cattaacaga agagagctgt gtgcagcacg gaggaagtgg agtctgagga atacaacagc    16620

aacaactcac caagcagaga atacaatggt tcttcatcac tatataaaac taacactttt    16680

ccttcaaagg tctatgtata attttcttca atgattagct ttttaatgag acaactcctt    16740

tcatccagac attcagatgc tttatataag ttggcaattt tcctgttaac caaactgaat    16800

tttattaaat gtttattaaa atgcacccag aaaacttgtc tcctcctgat gcctgagggg    16860

tttgcatgcc tgatcccaag ctgcattttt tcagaatgcg tgcatgatgc cccagttctg    16920

tactcatgat caccaggtgg cgttctgaaa tccactactg gggaaagatt tttaacagat    16980

attagtgaga ttagagttgg tgtcatttcc attgagtatc ctcttcaccc ctaagatgac    17040

acatctttac aacacaataa aagaacgtaa agccttattt ccacctgtaa ctcctgaatt    17100

gattcatttt cacgttataa ctacatttca aatatttcgg agaagttttt acacagggct    17160

tcagctatat actgatatac atatgcttac atgtgcttag gtgggaattc tactaaagga    17220

taaaggacac agtgtgaaaa caacatcaga gaatatcctg tacaacttcc ccaaaagtga    17280

caagttttct tgtacttaaa aatttaatcc tgataagaac taatgtgaaa taacatcatt    17340

ttggtttata aatatttgta atttttgaga catagaggca atatcatgat ataggaatac    17400

attcataaaa ctagactagc aaagcagata atgttttcat gatatggctt catgaggcaa    17460

agttgttgta catcaatatt atcattgtgc ccttatttaa ggattatatt ccattgtgaa    17520

aaaaatgtgc acactcttaa aaacacaaaa tgggtttcag aaagtttacc ttgagaagtg    17580

ggtttgaaat catcttgtgc ttggagctga cataagatac gcactcaata taatctcttc    17640

tggattctaa aatctaattg gcagtgatat ttcaaagcct taacatttca aggtggttaa    17700

ttaatatcta atgcatggta ttaaactttc tgaagcatga atttaaccta ggcaattatc    17760

tgattcattt tttttaaagt ttgtgctgcc aaaccagact gaagtattgt ttttctggac    17820

taatactatg agaatagtaa gtgagtcaaa aaataattgg gactgtcctt tttcccctgc    17880

ccacttccta gtatcaatac tcccccaacc agaaatgcag cagaatatcc tttttgctat    17940

aaaggaaaat actgtgtttt tatttgtttt tgcagaagaa aactggtgtt gcctatttgg    18000

actagatgta ggggcctgga agaaggaagt ggcagattca caggtggggt gaccaggatg    18060

ggaggaaaat agtggggcga gtatgtcatg gggagatttt gccacaaaga tacaaaacag    18120

aattgaagtg tgttagagct ggacaaccct ttgaaatgac agagtctaga ttcttcacca    18180

aacagatgaa aagacaagta gagacaacat gtacttgaga tataagctat acatctcatc    18240

actggaagaa aggagacttc agcctctttt caaggctttc cagaccacat ggaactctcc    18300

agagccctcc ttgaaagttt ttagaaaaac taccattttc agcaaagatt catgtgatta    18360

tgctgctgag gaccagtcat tctgtaaaca tcacatatgt gatgctttgt aaatgtatta    18420

attgtggtca attttcatgg atatttccca ttaacattgt attccatgaa caagtgatag    18480

aaaacatatg gaaattctct tttgatcaaa aggagtgtct cccaattagt ttacgtgtgt    18540

tagtattgct gacatattat tatcatcaca aaattccttt tatatctaga tggtatcaaa    18600

taagaaaaaa atgcatcatt tggtcaattg cttattgaag atcccagctg aagcctttct    18660

ttggtaaaga gcgcagaaag agaccatagc tattcttgga tgagaacctt gcctctacta    18720

aatagtttct gcttttcctc tctgtagcca gacagctcaa tagcctaggg agagtcgatg    18780

aaggatatgc aaattacatt tttcccattc tcagaacaaa gacagcaacc aatgagccag    18840

aggtttcttc tctctttgaa accaaatagc acgctgaatt tagggctatg acaaaaatgt    18900

tgttaaagca agagcaaaat catccttcct atggattctt ttctcagtgt ttacttaatt    18960

ctttttgcag tttggattgg agtttctagt aatgataatt aatgccattt tacatgatag    19020

cttcaatgca gaaatggtgt gagcctgagt tacaaatgac atgactaggg atacaaactt    19080

cgtctgtact aacatcctac caagcagatt ggaaacaaat actactacca ctaatattct    19140

gatgtaatta ataacatcta atagaaaaat agaaacatcg tgcttagcat gaaaccattg    19200

cacaatataa acctgctccc aaatggcaag gatttttgct accaatattt gttcttaatt    19260

ctccagttat tttaagtaaa taagtttcac atctaactac ctcagctact gttgttttat    19320

ttagaaacat gaaaccatgc actttgtaat caataagtct tttgtttaac atttcaaaag    19380

gatatttggt gcaaagcaat tttcaaaaat ttgtacatga tatacaccac ccaacctcag    19440

gaggttgtac ttaattttgt ttgtttgttt ctaaggttgg ttttgggtaa aatcctcatt    19500

tccactcaac atcaagataa gctgctctat atttgcttaa tttgccttaa acattttgtg    19560

ctcctttccc tgttcaattt ttttgttttg ttttaaatct atctctgaaa aaaaaatgga    19620

acaggtggca ggtgaacagc aaatggaaga gaatggacca gtaatttctc agtcccctgt    19680

tgtcaactat ctgcatgaca ttctgattgt gcaaaaatgc cattcctgtg cttccccctc    19740

cattacagaa taaggtccga gagaccccac gagtgtgcgt agggaacggt gtagacattt    19800

cccccagtat gagcacagtg cctggacctg aatgatcatc ttggcagttc ttgtgctttt    19860

actttgtaaa cattgtacaa atgtatttgg aattttattt gaaatggaga cttaaactag    19920

ttattaaatt tgtttccttc ctgtaaatat atatattcaa attccatgta tccaaacatc    19980

cctttagcgt tcagattgta agtgtgtctt tattcgcggg aggccactgt cagcaggcag    20040

tgacccccag tgccctagtt tgaagcacag tgtgtggagt atttgatgta ctacagtacc    20100

atagttattt tggtctgtta agtaagttgc aatttgtgat gaaatgaagt ggaaagtagt    20160

acttcataat gaacaaattt ccttggttac atggtttttc ttgtaaaact taaagaaaaa    20220

aaaagaaaac ttgaaatttt a                                              20241


<210> 26
<211> 650
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Ala Lys Ser Asp Gly Arg Leu Lys Met Lys Lys Ser Ser Asp 
1               5                   10                  15      


Val Ala Phe Thr Pro Leu Gln Asn Ser Asp His Ser Gly Ser Val Gln 
            20                  25                  30          


Gly Leu Ala Pro Gly Leu Pro Ser Gly Ser Gly Ala Glu Asp Glu Glu 
        35                  40                  45              


Ala Ala Gly Gly Gly Cys Cys Pro Asp Gly Gly Gly Cys Ser Arg Cys 
    50                  55                  60                  


Cys Cys Cys Cys Ala Gly Ser Gly Gly Ser Ala Gly Ser Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Val Ala Gly Pro Gly Gly Gly Gly Ala Gly Ser Ala Ala Leu 
                85                  90                  95      


Cys Leu Arg Leu Gly Arg Glu Gln Arg Arg Tyr Ser Leu Trp Asp Cys 
            100                 105                 110         


Leu Trp Ile Leu Ala Ala Val Ala Val Tyr Phe Ala Asp Val Gly Thr 
        115                 120                 125             


Asp Val Trp Leu Ala Val Asp Tyr Tyr Leu Arg Gly Gln Arg Trp Trp 
    130                 135                 140                 


Phe Gly Leu Thr Leu Phe Phe Val Val Leu Gly Ser Leu Ser Val Gln 
145                 150                 155                 160 


Val Phe Ser Phe Arg Trp Phe Val His Asp Phe Ser Thr Glu Asp Ser 
                165                 170                 175     


Ala Thr Ala Ala Ala Ala Ser Ser Cys Pro Gln Pro Gly Ala Asp Cys 
            180                 185                 190         


Lys Thr Val Val Gly Gly Gly Ser Ala Ala Gly Glu Gly Glu Ala Arg 
        195                 200                 205             


Pro Ser Thr Pro Gln Arg Gln Ala Ser Asn Ala Ser Lys Ser Asn Ile 
    210                 215                 220                 


Ala Ala Ala Asn Ser Gly Ser Asn Ser Ser Gly Ala Thr Arg Ala Ser 
225                 230                 235                 240 


Gly Lys His Arg Ser Ala Ser Cys Ser Phe Cys Ile Trp Leu Leu Gln 
                245                 250                 255     


Ser Leu Ile His Ile Leu Gln Leu Gly Gln Ile Trp Arg Tyr Phe His 
            260                 265                 270         


Thr Ile Tyr Leu Gly Ile Arg Ser Arg Gln Ser Gly Glu Asn Asp Arg 
        275                 280                 285             


Trp Arg Phe Tyr Trp Lys Met Val Tyr Glu Tyr Ala Asp Val Ser Met 
    290                 295                 300                 


Leu His Leu Leu Ala Thr Phe Leu Glu Ser Ala Pro Gln Leu Val Leu 
305                 310                 315                 320 


Gln Leu Cys Ile Ile Val Gln Thr His Ser Leu Gln Ala Leu Gln Gly 
                325                 330                 335     


Phe Thr Ala Ala Ala Ser Leu Val Ser Leu Ala Trp Ala Leu Ala Ser 
            340                 345                 350         


Tyr Gln Lys Ala Leu Arg Asp Ser Arg Asp Asp Lys Lys Pro Ile Ser 
        355                 360                 365             


Tyr Met Ala Val Ile Ile Gln Phe Cys Trp His Phe Phe Thr Ile Ala 
    370                 375                 380                 


Ala Arg Val Ile Thr Phe Ala Leu Phe Ala Ser Val Phe Gln Leu Tyr 
385                 390                 395                 400 


Phe Gly Ile Phe Ile Val Leu His Trp Cys Ile Met Thr Phe Trp Ile 
                405                 410                 415     


Val His Cys Glu Thr Glu Phe Cys Ile Thr Lys Trp Glu Glu Ile Val 
            420                 425                 430         


Phe Asp Met Val Val Gly Ile Ile Tyr Ile Phe Ser Trp Phe Asn Val 
        435                 440                 445             


Lys Glu Gly Arg Thr Arg Cys Arg Leu Phe Ile Tyr Tyr Phe Val Ile 
    450                 455                 460                 


Leu Leu Glu Asn Thr Ala Leu Ser Ala Leu Trp Tyr Leu Tyr Lys Ala 
465                 470                 475                 480 


Pro Gln Ile Ala Asp Ala Phe Ala Ile Pro Ala Leu Cys Val Val Phe 
                485                 490                 495     


Ser Ser Phe Leu Thr Gly Val Val Phe Met Leu Met Tyr Tyr Ala Phe 
            500                 505                 510         


Phe His Pro Asn Gly Pro Arg Phe Gly Gln Ser Pro Ser Cys Ala Cys 
        515                 520                 525             


Glu Asp Pro Ala Ala Ala Phe Thr Leu Pro Pro Asp Val Ala Thr Ser 
    530                 535                 540                 


Thr Leu Arg Ser Ile Ser Asn Asn Arg Ser Val Val Ser Asp Arg Asp 
545                 550                 555                 560 


Gln Lys Phe Ala Glu Arg Asp Gly Cys Val Pro Val Phe Gln Val Arg 
                565                 570                 575     


Pro Thr Ala Pro Ser Thr Pro Ser Ser Arg Pro Pro Arg Ile Glu Glu 
            580                 585                 590         


Ser Val Ile Lys Ile Asp Leu Phe Arg Asn Arg Tyr Pro Ala Trp Glu 
        595                 600                 605             


Arg His Val Leu Asp Arg Ser Leu Arg Lys Ala Ile Leu Ala Phe Glu 
    610                 615                 620                 


Cys Ser Pro Ser Pro Pro Arg Leu Gln Tyr Lys Asp Asp Ala Leu Ile 
625                 630                 635                 640 


Gln Glu Arg Leu Glu Tyr Glu Thr Thr Leu 
                645                 650 


<210> 27
<211> 3652
<212> DNA
<213> Mus musculus

<400> 27
gcggcggcgg gcgagcgggc gctggagtag gagctgggga gcggcgcggc cggggaagga       60

agccagggcg aggcgaggag gtggcgggag gaggagacag cagggacagg tgtcagataa      120

aggagtgctc tcctccgctg ccgaggcatc atggccgcta agtcagacgg gaggctgaag      180

atgaagaaga gcagcgacgt ggcgttcacc ccgctgcaga actcggacaa ttcgggctct      240

gtgcaaggac tggctccagg cttgccgtcg gggtccggag ccgaggacac ggaggcggcc      300

ggaggcggct gctgcccgga cggcggtggc tgctcgcgct gctgctgctg ctgcgcgggg      360

agcggcggct cggcgggctc gggcggctcg ggcggcggcg gccggggcag cggggcgggc      420

tctgcggcgc tgtgcctgcg cctgggcagg gagcagcggc gttactcgct gtgggactgc      480

ctctggatcc tggccgccgt ggccgtgtac ttcgcggatg tgggaacgga catctggctc      540

gcggtggact actacctgcg tggccagcgc tggtggtttg ggctcaccct cttcttcgtg      600

gtgctgggct ccctttctgt gcaagtgttc agcttccgct ggtttgtgca tgatttcagc      660

accgaggaca gctccacgac caccacctcc agctgccagc agcctggagc agattgcaag      720

acggtggtca gcagtgggtc tgcagccggg gaaggcgagg ttcgtccttc cacgccgcag      780

aggcaagcat ccaacgccag caagagcaac atcgccgcca ccaacagcgg cagcaacagc      840

aacggggcca cccggaccag cggcaaacac aggtctgcgt cctgctcctt ttgcatctgg      900

ctcctgcagt cactcatcca catcttgcag cttgggcaaa tctggaggta tttgcacaca      960

atatacttag gtatccggag ccggcagagt ggggagagcg gcaggtggcg gttttactgg     1020

aagatggtgt acgagtatgc agatgtgagc atgctgcatc tgctagccac ttttctggaa     1080

agtgctccac aattggtcct gcagctctgc attattgtac agactcacag cttacaggcc     1140

ctccaaggtt tcacagcagc agcctccctt gtgtccttgg cttgggccct agcctcctac     1200

cagaaggctc ttcgggactc ccgagatgac aaaaagccca tcagctacat ggctgtcatc     1260

attcagttct gctggcattt cttcaccatc gctgccaggg tcatcacatt cgccctcttt     1320

gcctcggttt tccagctgta ttttgggata tttattgtcc tccattggtg catcatgact     1380

ttctggattg tccactgtga gacagaattc tgtatcacca aatgggaaga gattgtgttt     1440

gacatggtgg tgggcatcat ctacatcttc agttggttca atgtcaagga aggcaggaca     1500

cgctgcaggc tgttcattta ctattttgta atccttttgg aaaatacagc cttgagtgca     1560

ctctggtacc tctacaaagc tccccagatt gcagatgcat ttgccatccc tgcattgtgc     1620

gtggttttca gcagcttttt aacaggtgtt gtttttatgc tgatgtacta tgccttcttt     1680

catcccaatg ggcccagatt tgggcaatca ccaagttgtg cttgtgatga tccagccact     1740

gccttctctc tgcctccaga agtagccaca agcacactac ggtccatctc caacaaccgc     1800

agtgttgcca gtgaccgtga tcagaaattt gcagagcggg atggatgtgt acctgtgttt     1860

caagtgagac caactgcacc acccacccca tcatctcgac caccacggat tgaagaatca     1920

gtcattaaaa ttgacctgtt caggaataga tatccagcat gggagagaca tgtgttagat     1980

cgaagcctga gaaaggccat tttagccttt gaatgttccc catctcctcc aaggctgcag     2040

tacaaggatg atgcccttat tcaggagagg ctggaatatg aaaccacttt ataaaataca     2100

aggagccgca atgtccacat gaaggggtaa cagcagggct gtggcaataa tgacacctta     2160

tccaagagta gggcagcgag ctgtatgttc ttagttgtgg tatggtttga tcttccatca     2220

gctgactgcc tgctgctggt gtctattcaa gccagcagtg ctgagagtct cttacactgt     2280

cagcttaata tgactgttgc tacaaactcc tccagcagag atttggggca cattcactgg     2340

aggataacat tattgtgaaa aatgttgcct ctaatcatta gggtattttg atgggtttta     2400

ctaagttttg cataaatata ttcacacacc accataccac ccctcaatca aaggagttaa     2460

ggtggggatg gagagatgac tcattagtta agagcactga ctgctcttgc aaaggaccca     2520

ggcttgagta gttcactgca actctaattc cagaagatct aatgtccatt tttggcctcc     2580

tcaagcactg cacacacatg gtgcatagac atatatgcag gcaaaatacc catacacata     2640

gcataaaaat aaatctcaaa gaaaaaaagc ttaggtgatt tccttgatgc aaagctcaca     2700

acatactcca ggaagaaagc agcatacttg ggacaattat ataaactgtt ctctcctttg     2760

caaaccagta gcatcaatga agtggacagc aagactcaag tgtttacact cgtactaact     2820

agctttgatg ggatgattct ttttctacat atttcaggat ttgtttttac ttttaggttt     2880

tgcagatgag aacattcttc atgacagaaa tcctatgcag cacttatatg gcttttgatg     2940

agaccaagga gctcaatatc tgtaatgtaa attaaatgct aatcataatt cagtattcag     3000

ttgcaaaaat acaatatata aaaagagtct ttggggaagg gacagagtga gattcagatt     3060

ctcaggtgtg tgcatcttat attggaatgc acccacagag ccacaggaga ggaacaggga     3120

ctatttcaag gtctgtgttc atgtctgttt ccagaactgt ttccaggtgc agaatgacat     3180

gggtcagcag gtatgattcc ggaaaccacg tgccacatct ttcgagtgcc aaattttgtc     3240

caattacaga actgatatgg aatccccaaa atctgagaat aagtggtttc ccaaaacaga     3300

caaaagaaga ataatcaggt tccctgctgt gtacagactt accctcttcc catccaaggt     3360

caaaatgatg tgtctactag agactttggg acacaattta gcaagtgaga gcatacagat     3420

gcaatgtgta tgccattaaa aatactgcct ggactgcttg agggcttacc actccatcag     3480

ctaagatttg tatttgaatc atctgtaaat tcgtgctctt acaagcttct gagttttaaa     3540

tacctccaca cagcaagtaa acattcccgc tttctgtttt cggtgtcctt ggtcatggtg     3600

ctttttgttg cattaaaagt gccggtcaaa ctttaaaaaa aaaaaaaaaa aa             3652


<210> 28
<211> 647
<212> PRT
<213> Mus musculus

<400> 28
Met Ala Ala Lys Ser Asp Gly Arg Leu Lys Met Lys Lys Ser Ser Asp 
1               5                   10                  15      


Val Ala Phe Thr Pro Leu Gln Asn Ser Asp Asn Ser Gly Ser Val Gln 
            20                  25                  30          


Gly Leu Ala Pro Gly Leu Pro Ser Gly Ser Gly Ala Glu Asp Thr Glu 
        35                  40                  45              


Ala Ala Gly Gly Gly Cys Cys Pro Asp Gly Gly Gly Cys Ser Arg Cys 
    50                  55                  60                  


Cys Cys Cys Cys Ala Gly Ser Gly Gly Ser Ala Gly Ser Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Arg Gly Ser Gly Ala Gly Ser Ala Ala Leu Cys Leu 
                85                  90                  95      


Arg Leu Gly Arg Glu Gln Arg Arg Tyr Ser Leu Trp Asp Cys Leu Trp 
            100                 105                 110         


Ile Leu Ala Ala Val Ala Val Tyr Phe Ala Asp Val Gly Thr Asp Ile 
        115                 120                 125             


Trp Leu Ala Val Asp Tyr Tyr Leu Arg Gly Gln Arg Trp Trp Phe Gly 
    130                 135                 140                 


Leu Thr Leu Phe Phe Val Val Leu Gly Ser Leu Ser Val Gln Val Phe 
145                 150                 155                 160 


Ser Phe Arg Trp Phe Val His Asp Phe Ser Thr Glu Asp Ser Ser Thr 
                165                 170                 175     


Thr Thr Thr Ser Ser Cys Gln Gln Pro Gly Ala Asp Cys Lys Thr Val 
            180                 185                 190         


Val Ser Ser Gly Ser Ala Ala Gly Glu Gly Glu Val Arg Pro Ser Thr 
        195                 200                 205             


Pro Gln Arg Gln Ala Ser Asn Ala Ser Lys Ser Asn Ile Ala Ala Thr 
    210                 215                 220                 


Asn Ser Gly Ser Asn Ser Asn Gly Ala Thr Arg Thr Ser Gly Lys His 
225                 230                 235                 240 


Arg Ser Ala Ser Cys Ser Phe Cys Ile Trp Leu Leu Gln Ser Leu Ile 
                245                 250                 255     


His Ile Leu Gln Leu Gly Gln Ile Trp Arg Tyr Leu His Thr Ile Tyr 
            260                 265                 270         


Leu Gly Ile Arg Ser Arg Gln Ser Gly Glu Ser Gly Arg Trp Arg Phe 
        275                 280                 285             


Tyr Trp Lys Met Val Tyr Glu Tyr Ala Asp Val Ser Met Leu His Leu 
    290                 295                 300                 


Leu Ala Thr Phe Leu Glu Ser Ala Pro Gln Leu Val Leu Gln Leu Cys 
305                 310                 315                 320 


Ile Ile Val Gln Thr His Ser Leu Gln Ala Leu Gln Gly Phe Thr Ala 
                325                 330                 335     


Ala Ala Ser Leu Val Ser Leu Ala Trp Ala Leu Ala Ser Tyr Gln Lys 
            340                 345                 350         


Ala Leu Arg Asp Ser Arg Asp Asp Lys Lys Pro Ile Ser Tyr Met Ala 
        355                 360                 365             


Val Ile Ile Gln Phe Cys Trp His Phe Phe Thr Ile Ala Ala Arg Val 
    370                 375                 380                 


Ile Thr Phe Ala Leu Phe Ala Ser Val Phe Gln Leu Tyr Phe Gly Ile 
385                 390                 395                 400 


Phe Ile Val Leu His Trp Cys Ile Met Thr Phe Trp Ile Val His Cys 
                405                 410                 415     


Glu Thr Glu Phe Cys Ile Thr Lys Trp Glu Glu Ile Val Phe Asp Met 
            420                 425                 430         


Val Val Gly Ile Ile Tyr Ile Phe Ser Trp Phe Asn Val Lys Glu Gly 
        435                 440                 445             


Arg Thr Arg Cys Arg Leu Phe Ile Tyr Tyr Phe Val Ile Leu Leu Glu 
    450                 455                 460                 


Asn Thr Ala Leu Ser Ala Leu Trp Tyr Leu Tyr Lys Ala Pro Gln Ile 
465                 470                 475                 480 


Ala Asp Ala Phe Ala Ile Pro Ala Leu Cys Val Val Phe Ser Ser Phe 
                485                 490                 495     


Leu Thr Gly Val Val Phe Met Leu Met Tyr Tyr Ala Phe Phe His Pro 
            500                 505                 510         


Asn Gly Pro Arg Phe Gly Gln Ser Pro Ser Cys Ala Cys Asp Asp Pro 
        515                 520                 525             


Ala Thr Ala Phe Ser Leu Pro Pro Glu Val Ala Thr Ser Thr Leu Arg 
    530                 535                 540                 


Ser Ile Ser Asn Asn Arg Ser Val Ala Ser Asp Arg Asp Gln Lys Phe 
545                 550                 555                 560 


Ala Glu Arg Asp Gly Cys Val Pro Val Phe Gln Val Arg Pro Thr Ala 
                565                 570                 575     


Pro Pro Thr Pro Ser Ser Arg Pro Pro Arg Ile Glu Glu Ser Val Ile 
            580                 585                 590         


Lys Ile Asp Leu Phe Arg Asn Arg Tyr Pro Ala Trp Glu Arg His Val 
        595                 600                 605             


Leu Asp Arg Ser Leu Arg Lys Ala Ile Leu Ala Phe Glu Cys Ser Pro 
    610                 615                 620                 


Ser Pro Pro Arg Leu Gln Tyr Lys Asp Asp Ala Leu Ile Gln Glu Arg 
625                 630                 635                 640 


Leu Glu Tyr Glu Thr Thr Leu 
                645         


<210> 29
<211> 3727
<212> DNA
<213> Rattus norvegicus

<400> 29
atgggtagag ccccagggcc ttcgcatttc tccaggctgg ggtttgccag tacagcatcc       60

ctgaggctgc cctctcctta tcccgagggc ccgccctctg ctgccggctt tgctttaggt      120

gttccagccc tacaggtcct ctgccaccca ggatctccaa agcatggcac gcccaccacc      180

gctgctagta cagaagccca gcttcctagt tgaagcgtgc tgttcaccct cgccggcaac      240

acacctagca ccgtaccaca cccaaccagg tgcccgaact cccagtacaa tacaaagaga      300

cctgctcttc cccatccctc gccgctgcca cgcccgctcg agtccacggc cccctgccct      360

cggcggtggc ccaacacaga gactccaaca cgcggcgcgc tctgcccacc ccatcccccc      420

cagcgtcaag gaaatccacc caacgttttc cgaaatccca cgagcccggg cctccgactg      480

ctgtgctgct gccctcggcg tccagcactg gccagcccgg cacccccacc cgccgctccc      540

ctcgatctcg ctcgctgtgg actactacct gctcggccag cgctggtggt ttgggctcac      600

cctgttcttc gtggttctgg gctcgctctc tgtgcaagtg ttcagcttcc ggtggtttgt      660

gcacgatttc agcaccgagg acagcgccac gaccaccgcc tccacctgcc agcagcctgg      720

agcggattgc aagaccgtgg tcagcagtgg gtctgcagcc ggggaaggcg aggctcgtcc      780

ttccacgccg cagaggcaag catccaacgc cagcaagagc aacatcgccg ccaccaacag      840

cggaagcaac agcaacgggg ccaccaggac cagcggcaaa cacaggtctg cgtcctgctc      900

cttctgcatc tggctcctgc agtcactcat ccacatcttg cagctcgggc aagtctggag      960

gtatttgcac acaatatact taggtatccg gagccggcag agcggggaga gcagtaggtg     1020

gcggttttac tggaagatgg tgtacgagta tgcagatgtg agcatgctgc acctgctggc     1080

cacctttctg gaaagtgcgc cacaactggt cctgcagctc tgcataattg tacagactca     1140

cagcttacag gccctccaag gttttacagc agcagcctcc cttgtgtcct tggcttgggc     1200

cctagcctcc taccagaagg ctcttcggga ctcccgagat gacaaaaagc ctatcagcta     1260

catggctgtc atcatccagt tctgctggca tttcttcacc attgctgcca gggtcatcac     1320

attcgccctc tttgcctcgg ttttccagct gtattttggg atattcattg tcctccactg     1380

gtgcatcatg accttctgga ttgtccactg tgagacagaa ttctgtatca ccaaatggga     1440

agagattgtg tttgacatgg tggtgggtat catctacatc ttcagttggt tcaatgtcaa     1500

ggaaggcagg acacgctgca ggctgttcat ttactatttt gtaatccttt tggaaaatac     1560

agccttgagt gcactctggt acctctacaa agctccccag attgcggatg catttgccat     1620

ccctgcattg tgcgtggttt tcagcagctt tttaacaggt gtcgttttta tgctgatgta     1680

ctatgccttc ttccatccca atgggcccag atttgggcag tcaccaagtt gtgcttgtga     1740

cgaccctgcc actgccttct ctatgcctcc agaagtagcc acaagcacac tacggtccat     1800

ctctaacaac cgcagtgttg ccagtgaccg tgatcagaaa tttgcagagc gggatggatg     1860

tgtacctgtg tttcaggtga gaccaactgc accacctact ccatcatctc gaccaccgcg     1920

gattgaagaa tcagtcatta aaattgacct gttcaggaat agatatccag catgggagag     1980

acatgtgttg gaccgaagcc tgagaaaggc cattttagcc tttgaatgtt ccccatctcc     2040

tccaaggctg cagtacaaag acgatgccct tattcaggag aggctggaat atgaaaccac     2100

tttataaaac acaaagaacc gtaatgtcca tataaagggg taacagcagg gctgaggcaa     2160

taatgacacc ttatccaaga gtagggcaat gagctatatg ttcttagtcc aaacattgtc     2220

acggtatggt ttgatcttcc atcagctgac tgcctgctgc cggtgagcat tcaagccagt     2280

agtgctgaga gtttcttact ccgctgaaag gggcgatgtc agcttagtat gactgttgct     2340

acaaattcct ccagcacagg cttggggcac attcactgga ggataacatt attgtgagga     2400

aatgttgcct ctaatcatta gggtatttta atggagttta ctaatctttg cataaatatg     2460

ttcataccac caccaccacc acccctctat caaaggagtt aaggtggagc tggagagatg     2520

actcagtagt taagagcact gactgctctt gcaaagaacc caggcttgag ccccagcatc     2580

catttgatag ttcactacaa ctctaattcc agaatatcca atgcccattt ttggcctcct     2640

caggcactgc actcacatgg tgcacagaca tatatgcagg caaaataccc atacacataa     2700

aataaaaata aatctccaaa aacaaaacaa aacaaaaaca aaaaaaagtt taggtgattt     2760

ccttgatgca aagctcacaa cagactccaa gaagaaagca acatgcttgg aatgacccta     2820

gaaaccattc tctcctttgc aaaccagtag catcaatgac aaaacctgtg cagtggacag     2880

caagactcaa gtgtttacac tgatactagc atcgatggga tgattctttt tctacgcatt     2940

tcaggatttg ttttttactt ttaagttttg cagatgagaa cattctttat gacagaaatc     3000

ctatgcagca catgtatggc ttttgaagag accaaggagc tcaatattca tccgtgatgt     3060

aaattaaatg ctaatcatga ttcagtattc aattgcaaaa ataaaattta tatacaaaga     3120

gccatggcgg gagggacaga atgagaatca gattctcagg tgtgtgcatc tcctattgaa     3180

atacacccac aaagccacgg tcgagaaaaa gggactgttt ccaggtctgt ttctaggtgc     3240

aggatgagca cgggtcagca ggtgtgattc cggaaaccac atgccacacc tttctagtgc     3300

caaacttcgt tcaatcacag aactgatacg gtattccccc agactgagaa taagtggtgt     3360

cccaaaacag acaaggacag aataatcagg ttcttggctg tatacagact taccctcttc     3420

ccatccaagg tcaaagcgat gtgtctacta gagactttgg gacacctttt agcaagcgag     3480

tgcatacaga tgcaatgtgt atgctatcaa aaataaaaac tgcctggact gcttgagggc     3540

ttaccactcc atcagctaag atttgtatgt gaatcatctg taaagttgtg cttttacaag     3600

cttctgagtt ttaaatacct ccatacagca agtaaacatt cccgctttct gttcttggtg     3660

tcattggtca tggtgctttt tgttgcatta aaagtgccgg tcaaacttta aaaaaaaaaa     3720

aaaaaaa                                                               3727


<210> 30
<211> 647
<212> PRT
<213> Rattus norvegicus

<400> 30
Met Ala Arg Pro Pro Pro Leu Leu Val Gln Lys Pro Ser Phe Leu Val 
1               5                   10                  15      


Glu Ala Cys Cys Ser Pro Ser Pro Ala Thr His Leu Ala Pro Tyr His 
            20                  25                  30          


Thr Gln Pro Gly Ala Arg Thr Pro Ser Thr Ile Gln Arg Asp Leu Leu 
        35                  40                  45              


Phe Pro Ile Pro Arg Arg Cys His Ala Arg Ser Ser Pro Arg Pro Pro 
    50                  55                  60                  


Ala Leu Gly Gly Gly Pro Thr Gln Arg Leu Gln His Ala Ala Arg Ser 
65                  70                  75                  80  


Ala His Pro Ile Pro Pro Ser Val Lys Glu Ile His Pro Thr Phe Ser 
                85                  90                  95      


Glu Ile Pro Arg Ala Arg Ala Ser Asp Cys Cys Ala Ala Ala Leu Gly 
            100                 105                 110         


Val Gln His Trp Pro Ala Arg His Pro His Pro Pro Leu Pro Ser Ile 
        115                 120                 125             


Ser Leu Ala Val Asp Tyr Tyr Leu Leu Gly Gln Arg Trp Trp Phe Gly 
    130                 135                 140                 


Leu Thr Leu Phe Phe Val Val Leu Gly Ser Leu Ser Val Gln Val Phe 
145                 150                 155                 160 


Ser Phe Arg Trp Phe Val His Asp Phe Ser Thr Glu Asp Ser Ala Thr 
                165                 170                 175     


Thr Thr Ala Ser Thr Cys Gln Gln Pro Gly Ala Asp Cys Lys Thr Val 
            180                 185                 190         


Val Ser Ser Gly Ser Ala Ala Gly Glu Gly Glu Ala Arg Pro Ser Thr 
        195                 200                 205             


Pro Gln Arg Gln Ala Ser Asn Ala Ser Lys Ser Asn Ile Ala Ala Thr 
    210                 215                 220                 


Asn Ser Gly Ser Asn Ser Asn Gly Ala Thr Arg Thr Ser Gly Lys His 
225                 230                 235                 240 


Arg Ser Ala Ser Cys Ser Phe Cys Ile Trp Leu Leu Gln Ser Leu Ile 
                245                 250                 255     


His Ile Leu Gln Leu Gly Gln Val Trp Arg Tyr Leu His Thr Ile Tyr 
            260                 265                 270         


Leu Gly Ile Arg Ser Arg Gln Ser Gly Glu Ser Ser Arg Trp Arg Phe 
        275                 280                 285             


Tyr Trp Lys Met Val Tyr Glu Tyr Ala Asp Val Ser Met Leu His Leu 
    290                 295                 300                 


Leu Ala Thr Phe Leu Glu Ser Ala Pro Gln Leu Val Leu Gln Leu Cys 
305                 310                 315                 320 


Ile Ile Val Gln Thr His Ser Leu Gln Ala Leu Gln Gly Phe Thr Ala 
                325                 330                 335     


Ala Ala Ser Leu Val Ser Leu Ala Trp Ala Leu Ala Ser Tyr Gln Lys 
            340                 345                 350         


Ala Leu Arg Asp Ser Arg Asp Asp Lys Lys Pro Ile Ser Tyr Met Ala 
        355                 360                 365             


Val Ile Ile Gln Phe Cys Trp His Phe Phe Thr Ile Ala Ala Arg Val 
    370                 375                 380                 


Ile Thr Phe Ala Leu Phe Ala Ser Val Phe Gln Leu Tyr Phe Gly Ile 
385                 390                 395                 400 


Phe Ile Val Leu His Trp Cys Ile Met Thr Phe Trp Ile Val His Cys 
                405                 410                 415     


Glu Thr Glu Phe Cys Ile Thr Lys Trp Glu Glu Ile Val Phe Asp Met 
            420                 425                 430         


Val Val Gly Ile Ile Tyr Ile Phe Ser Trp Phe Asn Val Lys Glu Gly 
        435                 440                 445             


Arg Thr Arg Cys Arg Leu Phe Ile Tyr Tyr Phe Val Ile Leu Leu Glu 
    450                 455                 460                 


Asn Thr Ala Leu Ser Ala Leu Trp Tyr Leu Tyr Lys Ala Pro Gln Ile 
465                 470                 475                 480 


Ala Asp Ala Phe Ala Ile Pro Ala Leu Cys Val Val Phe Ser Ser Phe 
                485                 490                 495     


Leu Thr Gly Val Val Phe Met Leu Met Tyr Tyr Ala Phe Phe His Pro 
            500                 505                 510         


Asn Gly Pro Arg Phe Gly Gln Ser Pro Ser Cys Ala Cys Asp Asp Pro 
        515                 520                 525             


Ala Thr Ala Phe Ser Met Pro Pro Glu Val Ala Thr Ser Thr Leu Arg 
    530                 535                 540                 


Ser Ile Ser Asn Asn Arg Ser Val Ala Ser Asp Arg Asp Gln Lys Phe 
545                 550                 555                 560 


Ala Glu Arg Asp Gly Cys Val Pro Val Phe Gln Val Arg Pro Thr Ala 
                565                 570                 575     


Pro Pro Thr Pro Ser Ser Arg Pro Pro Arg Ile Glu Glu Ser Val Ile 
            580                 585                 590         


Lys Ile Asp Leu Phe Arg Asn Arg Tyr Pro Ala Trp Glu Arg His Val 
        595                 600                 605             


Leu Asp Arg Ser Leu Arg Lys Ala Ile Leu Ala Phe Glu Cys Ser Pro 
    610                 615                 620                 


Ser Pro Pro Arg Leu Gln Tyr Lys Asp Asp Ala Leu Ile Gln Glu Arg 
625                 630                 635                 640 


Leu Glu Tyr Glu Thr Thr Leu 
                645         


<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ile Gly Asn Arg 
1               


<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Val Ala Asn Arg 
1               


<210> 33
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Ile Glu Pro Asp 
1               


<210> 34
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Val Glu Pro Asp 
1               


<210> 35
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Ile Glu Thr Asp 
1               


<210> 36
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Ile Gln Ala Asp 
1               


<210> 37
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Pro Thr Ser Tyr 
1               


<210> 38
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Tyr Arg Phe Lys 
1               


<210> 39
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Lys Val Pro Leu 
1               


<210> 40
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Trp Glu His Asp 
1               


<210> 41
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Phe Glu Ala Asp 
1               


<210> 42
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Tyr Val His Asp 
1               


<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Leu Glu Ser Asp 
1               


<210> 44
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Trp Glu His Asp 
1               


<210> 45
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Leu Glu His Asp 
1               


<210> 46
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Trp Glu His Asp 
1               


<210> 47
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Leu Glu His Asp 
1               


<210> 48
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Asp Glu Val Asp 
1               


<210> 49
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Asp Gly Pro Asp 
1               


<210> 50
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Asp Glu Pro Asp 
1               


<210> 51
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Asp Glu Leu Asp 
1               


<210> 52
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Asp Glu Glu Asp 
1               


<210> 53
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Asp Glu Val Asp 
1               


<210> 54
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Asp Glu His Asp 
1               


<210> 55
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Val Glu His Asp 
1               


<210> 56
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Val Glu Ile Asp 
1               


<210> 57
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Leu Glu Thr Asp 
1               


<210> 58
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Leu Glu His Asp 
1               


<210> 59
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Asp Glu Thr Asp 
1               


<210> 60
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Val Gly Pro Asp 
1               


<210> 61
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(25) 
<223> This sequence may encompass 1-5 "Gly Gly Gly Gly Ser"
      repeating units

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 61
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 62
<211> 1708
<212> DNA
<213> Homo sapiens

<400> 62
cttttgaaat tctaaattct gatgcagaac gtatcagtga aactccctcc cactgtctct       60

tgtattagca tcaaggaagc gagaaaaaat aagcagcacc ctgagaatgg agacagtgtt      120

tgaagagatg gatgaagaaa gcacaggagg agtttcatct tcgaaagaag aaatagtcct      180

tggccagaga ctccatctaa gctttccttt tagcattatc ttctcaactg ttctctactg      240

tggtgaggtt gcctttggtt tatacatgtt tgaaatttat cgaaaagcta atgacacatt      300

ctggatgtca tttaccatca gctttattat tgtgggggca attttggatc aaattatcct      360

gatgtttttc aacaaagact tgaggagaaa taaggctgca ttactttttt ggcacattct      420

tcttttagga cctattgtga ggtgtttgca caccattaga aattaccaca aatggttgaa      480

aaatcttaaa caggagaagg aagagactca agttagcatc acaaagagaa acacgatgct      540

ggaaagggag attgcattct caatccggga taatttcatg cagcagaagg ctttcaagta      600

catgtcagtg attcaggctt ttctcggttc tgttccacaa ttaattttgc agatgtatat      660

cagtctcact atacgagaat ggcctttgaa tagagcattg ctgatgacat tttccctgtt      720

atcagttact tatggggcca ttcgctgcaa tatactggcc atccagatca gcaatgatga      780

tactaccatt aagctaccgc cgatagaatt cttctgtgtc gtgatgtggc gttttttgga      840

ggttatctca cgtgtagtga ctctggcatt tttcattgca tctctgaaac tgaagagcct      900

acccgttttg ttaatcatat attttgtatc attgttggca ccgtggctgg agttttggaa      960

aagtggagct catcttcctg gcaacaaaga aaataattcc aatatggtgg gtacagtact     1020

gatgcttttc ttgatcacac tgctatatgc tgccatcaac ttctcctgct ggtcagcagt     1080

gaaactgcag ttgtcagatg acaaaataat tgacgggaga cagaggtggg gccatagaat     1140

cctacactac agctttcagt ttttagaaaa tgtgataatg atattggtat ttaggttctt     1200

tggagggaaa actttgctga attgttgtga ctcattaatt gccgtgcagc tcatcataag     1260

ctacctattg gccactggct ttatgctcct cttctatcag tatttgtacc catggcagtc     1320

aggcaaagtg ttgccaggac gtactgaaaa tcagccagaa gcaccgtact attatgtaaa     1380

catcgagaaa actgaaaaga ataaaaataa gcagctgagg aattactgtc actcctgcaa     1440

tagggttgga tatttttcaa tcagaaaaag tatgacatgt tcataaaata tacatatata     1500

ctttcacaga acaatgagta aagatgctga atgtgacttg ttaagaggct cttaaattta     1560

aaaaatatac acagcaaaat cttggaagtg gtttctaata aaattcattt atgttctcct     1620

gtgaacgtgc cttagtaatt tttgttttct taactataat tatacaattc attaaataaa     1680

acaaaataaa aaaaaaaaaa aaaaaaaa                                        1708


<210> 63
<211> 459
<212> PRT
<213> Homo sapiens

<400> 63
Met Glu Thr Val Phe Glu Glu Met Asp Glu Glu Ser Thr Gly Gly Val 
1               5                   10                  15      


Ser Ser Ser Lys Glu Glu Ile Val Leu Gly Gln Arg Leu His Leu Ser 
            20                  25                  30          


Phe Pro Phe Ser Ile Ile Phe Ser Thr Val Leu Tyr Cys Gly Glu Val 
        35                  40                  45              


Ala Phe Gly Leu Tyr Met Phe Glu Ile Tyr Arg Lys Ala Asn Asp Thr 
    50                  55                  60                  


Phe Trp Met Ser Phe Thr Ile Ser Phe Ile Ile Val Gly Ala Ile Leu 
65                  70                  75                  80  


Asp Gln Ile Ile Leu Met Phe Phe Asn Lys Asp Leu Arg Arg Asn Lys 
                85                  90                  95      


Ala Ala Leu Leu Phe Trp His Ile Leu Leu Leu Gly Pro Ile Val Arg 
            100                 105                 110         


Cys Leu His Thr Ile Arg Asn Tyr His Lys Trp Leu Lys Asn Leu Lys 
        115                 120                 125             


Gln Glu Lys Glu Glu Thr Gln Val Ser Ile Thr Lys Arg Asn Thr Met 
    130                 135                 140                 


Leu Glu Arg Glu Ile Ala Phe Ser Ile Arg Asp Asn Phe Met Gln Gln 
145                 150                 155                 160 


Lys Ala Phe Lys Tyr Met Ser Val Ile Gln Ala Phe Leu Gly Ser Val 
                165                 170                 175     


Pro Gln Leu Ile Leu Gln Met Tyr Ile Ser Leu Thr Ile Arg Glu Trp 
            180                 185                 190         


Pro Leu Asn Arg Ala Leu Leu Met Thr Phe Ser Leu Leu Ser Val Thr 
        195                 200                 205             


Tyr Gly Ala Ile Arg Cys Asn Ile Leu Ala Ile Gln Ile Ser Asn Asp 
    210                 215                 220                 


Asp Thr Thr Ile Lys Leu Pro Pro Ile Glu Phe Phe Cys Val Val Met 
225                 230                 235                 240 


Trp Arg Phe Leu Glu Val Ile Ser Arg Val Val Thr Leu Ala Phe Phe 
                245                 250                 255     


Ile Ala Ser Leu Lys Leu Lys Ser Leu Pro Val Leu Leu Ile Ile Tyr 
            260                 265                 270         


Phe Val Ser Leu Leu Ala Pro Trp Leu Glu Phe Trp Lys Ser Gly Ala 
        275                 280                 285             


His Leu Pro Gly Asn Lys Glu Asn Asn Ser Asn Met Val Gly Thr Val 
    290                 295                 300                 


Leu Met Leu Phe Leu Ile Thr Leu Leu Tyr Ala Ala Ile Asn Phe Ser 
305                 310                 315                 320 


Cys Trp Ser Ala Val Lys Leu Gln Leu Ser Asp Asp Lys Ile Ile Asp 
                325                 330                 335     


Gly Arg Gln Arg Trp Gly His Arg Ile Leu His Tyr Ser Phe Gln Phe 
            340                 345                 350         


Leu Glu Asn Val Ile Met Ile Leu Val Phe Arg Phe Phe Gly Gly Lys 
        355                 360                 365             


Thr Leu Leu Asn Cys Cys Asp Ser Leu Ile Ala Val Gln Leu Ile Ile 
    370                 375                 380                 


Ser Tyr Leu Leu Ala Thr Gly Phe Met Leu Leu Phe Tyr Gln Tyr Leu 
385                 390                 395                 400 


Tyr Pro Trp Gln Ser Gly Lys Val Leu Pro Gly Arg Thr Glu Asn Gln 
                405                 410                 415     


Pro Glu Ala Pro Tyr Tyr Tyr Val Asn Ile Glu Lys Thr Glu Lys Asn 
            420                 425                 430         


Lys Asn Lys Gln Leu Arg Asn Tyr Cys His Ser Cys Asn Arg Val Gly 
        435                 440                 445             


Tyr Phe Ser Ile Arg Lys Ser Met Thr Cys Ser 
    450                 455                 


<210> 64
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Asn Leu Val Pro Met Val Ala Thr Val Gln 
1               5                   10  


<210> 65
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> CDS
<222> (1)..(96)

<400> 65
tat tat cat tgg ctg cac ccg agt tgc tgc tgg aag cct gac ccg gac         48
Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Asp           
1               5                   10                  15                

cag gtt gat gga gcg cgg tcc ttg ctc tcc cca gaa ggc tac cag ttg c       97
Gln Val Asp Gly Ala Arg Ser Leu Leu Ser Pro Glu Gly Tyr Gln Leu           
            20                  25                  30                    


<210> 66
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Asp 
1               5                   10                  15      


Gln Val Asp Gly Ala Arg Ser Leu Leu Ser Pro Glu Gly Tyr Gln Leu 
            20                  25                  30          


<210> 67
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(108)

<400> 67
tat tat cat tgg ctg cac ccg agt tgc tgc tgg aag cct gac ccg gtg         48
Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Val           
1               5                   10                  15                

gga cct gat ttt ggt aga gaa ttc gcg cgg tcc ttg ctc tcc cca gaa         96
Gly Pro Asp Phe Gly Arg Glu Phe Ala Arg Ser Leu Leu Ser Pro Glu           
            20                  25                  30                    

ggc tac cag ttg                                                        108
Gly Tyr Gln Leu                                                           
        35                                                                


<210> 68
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Val 
1               5                   10                  15      


Gly Pro Asp Phe Gly Arg Glu Phe Ala Arg Ser Leu Leu Ser Pro Glu 
            20                  25                  30          


Gly Tyr Gln Leu 
        35      


<210> 69
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(120)

<400> 69
tat tat cat tgg ctg cac ccg agt tgc tgc tgg aag cct gac ccg gga         48
Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Gly           
1               5                   10                  15                

tcg gtg gga cct gat ttt ggt aga gaa ttc ggc agt gcg cgg tcc ttg         96
Ser Val Gly Pro Asp Phe Gly Arg Glu Phe Gly Ser Ala Arg Ser Leu           
            20                  25                  30                    

ctc tcc cca gaa ggc tac cag ttg                                        120
Leu Ser Pro Glu Gly Tyr Gln Leu                                           
        35                  40                                            


<210> 70
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Tyr Tyr His Trp Leu His Pro Ser Cys Cys Trp Lys Pro Asp Pro Gly 
1               5                   10                  15      


Ser Val Gly Pro Asp Phe Gly Arg Glu Phe Gly Ser Ala Arg Ser Leu 
            20                  25                  30          


Leu Ser Pro Glu Gly Tyr Gln Leu 
        35                  40  


