                               SEQUENCE LISTING

<110> DEKA BIOSCIENCES, INC.
 
<120> Dual Cytokine Fusion Proteins Comprising IL-10

<130> 039451.00032

<140>
<141>

<160> 63    

<170> PatentIn version 3.5

<210> 1
<211> 178
<212> PRT
<213> Homo sapiens

<220>
<223> Human IL-10 Amino Acid Sequence

<400> 1
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 2
<211> 1629
<212> DNA
<213> Homo sapiens

<220>
<223> Human IL-10 Nucleic Acid Sequence

<400> 2
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatc                                                             1629


<210> 3
<211> 147
<212> PRT
<213> Human gammaherpesvirus 4

<220>
<223> EBV IL-10 Amino Acid Sequence

<400> 3
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp  
1               5                   10                  15     


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Val Asp  
            20                  25                  30           


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ala Lys Asp His Val Asn
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg 
145                  


<210> 4
<211> 632
<212> DNA
<213> Human gammaherpesvirus 4

<220>
<223> EBV IL-10 Nucleic Acid Sequence

<400> 4
tataaatcac ttccctatct caggtaggcc tgcacacctt aggtatggag cgaaggttag       60

tggtcactct gcagtgcctg gtgctgcttt acctggcacc tgagtgtgga ggtacagacc      120

aatgtgacaa ttttccccaa atgttgaggg acctaagaga tgccttcagt cgtgttaaaa      180

cctttttcca gacaaaggac gaggtagata accttttgct caaggagtct ctgctagagg      240

actttaaggg ctaccttgga tgccaggccc tgtcagaaat gatccaattc tacctggagg      300

aagtcatgcc acaggctgaa aaccaggacc ctgaagccaa agaccatgtc aattctttgg      360

gtgaaaatct aaagacccta cggctccgcc tgcgcaggtg ccacaggttc ctgccgtgtg      420

agaacaagag taaagctgtg gaacagataa aaaatgcctt taacaagctg caggaaaaag      480

gaatttacaa agccatgagt gaatttgaca tttttattaa ctacatagaa gcatacatga      540

caattaaagc caggtgataa ttccataccc tggaagcagg agatgggtgc atttcacccc      600

aaccccccct ttcgactgtc atttacaata aa                                    632


<210> 5
<211> 177
<212> PRT
<213> Human betaherpesvirus 5

<220>
<223> CMV IL-10 Amino Acid Sequence

<400> 5
Met Leu Ser Val Met Val Ser Ser Ser Leu Val Leu Ile Val Phe Phe 
1               5                   10                  15      


Leu Gly Ala Ser Glu Glu Ala Lys Pro Ala Ala Thr Thr Thr Thr Ile 
            20                  25                  30          


Lys Asn Thr Lys Pro Gln Cys Arg Pro Glu Asp Tyr Ala Ser Arg Leu 
        35                  40                  45              


Gln Asp Leu Arg Val Thr Phe His Arg Val Lys Pro Thr Leu Gln Arg 
    50                  55                  60                  


Glu Asp Asp Tyr Ser Val Trp Leu Asp Gly Thr Val Val Lys Gly Cys 
65                  70                  75                  80  


Trp Gly Cys Ser Val Met Asp Trp Leu Leu Arg Arg Tyr Leu Glu Ile 
                85                  90                  95      


Val Phe Pro Ala Gly Asp His Val Tyr Pro Gly Leu Lys Thr Glu Leu 
            100                 105                 110         


His Ser Met Arg Ser Thr Leu Glu Ser Ile Tyr Lys Asp Met Arg Gln 
        115                 120                 125             


Cys Pro Leu Leu Gly Cys Gly Asp Lys Ser Val Ile Ser Arg Leu Ser 
    130                 135                 140                 


Gln Glu Ala Glu Arg Lys Ser Asp Asn Gly Thr Arg Lys Gly Leu Ser 
145                 150                 155                 160 


Glu Leu Asp Thr Leu Phe Ser Arg Leu Glu Glu Tyr Leu His Ser Arg 
                165                 170                 175     


Lys 
    


<210> 6
<211> 693
<212> DNA
<213> Human betaherpesvirus 5

<220>
<223> CMV IL-10 Nucleic Acid Sequence

<400> 6
atgctgtcgg tgatggtctc ttcctctctg gtcctgatcg tcttttttct aggcgcttcc       60

gaggaggcga agccggcggc gacgacgacg acgataaaga atacaaagcc gcagtgtcgt      120

ccggaggatt acgcgagcag attgcaagat ctccgcgtca cctttcatcg agtaaaacct      180

acgttggtag gtcatgtagg tacggtttat tgcgacggtc tttcttttcc gcgtgtcggg      240

tgacgtagtt ttcctcttgt agcaacgtga ggacgactac tccgtgtggc tcgacggtac      300

ggtggtcaaa ggctgttggg gatgcagcgt catggactgg ttgttgaggc ggtatctgga      360

gatcgtgttc cccgcaggcg accacgtcta tcctggactt aagacggaat tgcatagtat      420

gcgctcgacg ctagaatcca tctacaaaga catgcggcaa tgcgtaagtg tctctgtggc      480

ggcgctgtcc gcgcagaggt aacaacgtgt tcatagcacg ctgttttact tttgtcgggc      540

tcccagcctc tgttaggttg cggagataag tccgtgatta gtcggctgtc tcaggaggcg      600

gaaaggaaat cggataacgg cacgcggaaa ggtctcagcg agttggacac gttgtttagc      660

cgtctcgaag agtatctgca ctcgagaaag tag                                   693


<210> 7
<211> 178
<212> PRT
<213> Mus musculus

<220>
<223> Mouse IL-10 Amino Acid Sequence

<400> 7
Met Pro Gly Ser Ala Leu Leu Cys Cys Leu Leu Leu Leu Thr Gly Met 
1               5                   10                  15      


Arg Ile Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His 
            20                  25                  30          


Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe 
        35                  40                  45              


Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
            100                 105                 110         


Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
    130                 135                 140                 


Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met 
                165                 170                 175     


Lys Ser 
        


<210> 8
<211> 1314
<212> DNA
<213> Mus musculus

<220>
<223> Mouse IL-10 Nucleic Acid Sequence

<400> 8
gggggggggg atttagagac ttgctcttgc actaccaaag ccacaaagca gccttgcaga       60

aaagagagct ccatcatgcc tggctcagca ctgctatgct gcctgctctt actgactggc      120

atgaggatca gcaggggcca gtacagccgg gaagacaata actgcaccca cttcccagtc      180

ggccagagcc acatgctcct agagctgcgg actgccttca gccaggtgaa gactttcttt      240

caaacaaagg accagctgga caacatactg ctaaccgact ccttaatgca ggactttaag      300

ggttacttgg gttgccaagc cttatcggaa atgatccagt tttacctggt agaagtgatg      360

ccccaggcag agaagcatgg cccagaaatc aaggagcatt tgaattccct gggtgagaag      420

ctgaagaccc tcaggatgcg gctgaggcgc tgtcatcgat ttctcccctg tgaaaataag      480

agcaaggcag tggagcaggt gaagagtgat tttaataagc tccaagacca aggtgtctac      540

aaggccatga atgaatttga catcttcatc aactgcatag aagcatacat gatgatcaaa      600

atgaaaagct aaaacacctg cagtgtgtat tgagtctgct ggactccagg acctagacag      660

agctctctaa atctgatcca gggatcttag ctaacggaaa caactccttg gaaaacctcg      720

tttgtacctc tctccgaaat atttattacc tctgatacct cagttcccat tctatttatt      780

cactgagctt ctctgtgaac tatttagaaa gaagcccaat attataattt tacagtattt      840

attattttta acctgtgttt aagctgtttc cattggggac actttatagt atttaaaggg      900

agattatatt atatgatggg aggggttctt ccttgggaag caattgaagc ttctattcta      960

aggctggcca cacttgagag ctgcagggcc ctttgctatg gtgtcctttc aattgctctc     1020

atccctgagt tcagagctcc taagagagtt gtgaagaaac tcatgggtct tgggaagaga     1080

aaccagggag atcctttgat gatcattcct gcagcagctc agagggttcc cctactgtca     1140

tcccccagcc gcttcatccc tgaaaactgt ggccagtttg ttatttataa ccacctaaaa     1200

ttagttctaa tagaactcat ttttaactag aagtaatgca attcctctgg gaatggtgta     1260

ttgtttgtct gcctttgtag cagcatctaa ttttgaataa atggatctta ttcg           1314


        
<210> 9
<211> 170
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Sequence DVLP5

<400> 9
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gly Thr Asp Gln Cys Asp Asn Phe Pro Gln 
            20                  25                  30          


Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe 
        35                  40                  45              


Gln Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu 
    50                  55                  60                  


Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile 
65                  70                  75                  80  


Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro 
                85                  90                  95      


Glu Ala Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu 
            100                 105                 110         


Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys 
        115                 120                 125             


Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu 
    130                 135                 140                 


Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr 
145                 150                 155                 160 


Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                165                 170 


<210> 10
<211> 170
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Sequence DVLP6

<400> 10
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gly Thr Asp Gln Cys Asp Asn Phe Pro Gln 
            20                  25                  30          


Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe 
        35                  40                  45              


Gln Thr Lys Asp Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu 
    50                  55                  60                  


Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile 
65                  70                  75                  80  


Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro 
                85                  90                  95      


Glu Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu 
            100                 105                 110         


Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys 
        115                 120                 125             


Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu 
    130                 135                 140                 


Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr 
145                 150                 155                 160 


Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                165                 170 


<210> 11
<211> 170
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Sequence DVLP7

<400> 11
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gly Thr Asp Gln Cys Asp Asn Phe Pro Gln 
            20                  25                  30          


Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe 
        35                  40                  45              


Gln Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu 
    50                  55                  60                  


Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile 
65                  70                  75                  80  


Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro 
                85                  90                  95      


Glu Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu 
            100                 105                 110         


Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys 
        115                 120                 125             


Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu 
    130                 135                 140                 


Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr 
145                 150                 155                 160 


Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                165                 170 


  
<210>  12
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DV05 Amino Acid Sequence

<400>  12

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ala Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg 
145         



<210>  13
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DV05 Nucleic Acid Sequence

<220>
<221>  misc_feature
<222>  (225)..(225)
<223>  n is a, c, g, or t

<400>  13
accgaccagt gcgacaactt ccctcagatg ctgcgggacc tgagagatgc cttctccaga       60

gtgaaaacat tcttccagac caaggacgag ctggacaacc tgctgctgaa agagtccctg      120

ctggaagatt tcaagggcta cctgggctgt caggccctgt ccgagatgat ccagttctac      180

ctggaagaag tgatgcccca ggccgagaat caggaccccg aggcnaagga ccacgtgaac      240

tccctgggcg agaacctgaa aaccctgcgg ctgagactgc ggcggtgcca cagatttctg      300

ccctgcgaga acaagtccaa ggccgtggaa cagatcaaga acgccttcaa caagctgcaa      360

gagaagggca tctacaaggc catgagcgag ttcgacatct tcatcaacta catcgaggcc      420

tacatgacca tcaaggccag a                                                441



<210>  14
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DV06 Amino Acid Sequence

<400>  14

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Val Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg 
145         



<210>  15
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DV06 Nucleic Acid Sequence

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  n is a, c, g, or t

<400>  15
accgaccagt gcgacaactt ccctcagatg ctgcgggacc tgagagatgc cttctccaga       60

gtgaaaacat tcttccagac caaggacgag gtngacaacc tgctgctgaa agagtccctg      120

ctggaagatt tcaagggcta cctgggctgt caggccctgt ccgagatgat ccagttctac      180

ctggaagaag tgatgcccca ggccgagaat caggaccccg agatcaagga ccacgtgaac      240

tccctgggcg agaacctgaa aaccctgcgg ctgagactgc ggcggtgcca cagatttctg      300

ccctgcgaga acaagtccaa ggccgtggaa cagatcaaga acgccttcaa caagctgcaa      360

gagaagggca tctacaaggc catgagcgag ttcgacatct tcatcaacta catcgaggcc      420

tacatgacca tcaaggccag a                                                441



<210>  16
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DV07 Amino Acid Sequence

<400>  16

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg 
145         



<210>  17
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DV07 Nucleic Acid Sequence

<400>  17
accgaccagt gcgacaactt ccctcagatg ctgcgggacc tgagagatgc cttctccaga       60

gtgaaaacat tcttccagac caaggacgag ctggacaacc tgctgctgaa agagtccctg      120

ctggaagatt tcaagggcta cctgggctgt caggccctgt ccgagatgat ccagttctac      180

ctggaagaag tgatgcccca ggccgagaat caggaccccg agatcaagga ccacgtgaac      240

tccctgggcg agaacctgaa aaccctgcgg ctgagactgc ggcggtgcca cagatttctg      300

ccctgcgaga acaagtccaa ggccgtggaa cagatcaaga acgccttcaa caagctgcaa      360

gagaagggca tctacaaggc catgagcgag ttcgacatct tcatcaacta catcgaggcc      420

tacatgacca tcaaggccag a                                                441



<210> 18
<211> 567
<212> PRT
<213> Artificial Sequence

<220>
<223> DV07 Ebo

<400> 18
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Thr Thr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Ile Gly Glu Val Asn Tyr Ser Gly Asn Ala Asn Tyr Asn Pro Ser 
    210                 215                 220                 


Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Thr Ser Arg Ile Arg Ser His Ile Ala Tyr Ser Trp Lys Gly Asp 
            260                 265                 270         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser 
    290                 295                 300                 


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
305                 310                 315                 320 


Arg Ala Ser Gln Ser Val Pro Arg Asn Tyr Ile Gly Trp Phe Gln Gln 
                325                 330                 335     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
            340                 345                 350         


Ala Ala Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        355                 360                 365             


Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr 
    370                 375                 380                 


Tyr Cys His Gln Tyr Asp Arg Leu Pro Tyr Thr Phe Gly Gln Gly Thr 
385                 390                 395                 400 


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg 
            420                 425                 430         


Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys 
        435                 440                 445             


Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe 
    450                 455                 460                 


Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr 
465                 470                 475                 480 


Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys 
                485                 490                 495     


Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg 
            500                 505                 510         


Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala 
        515                 520                 525             


Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile 
    530                 535                 540                 


Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala 
545                 550                 555                 560 


Tyr Met Thr Ile Lys Ala Arg 
                565         


<210> 19
<211> 561
<212> PRT
<213> Artificial Sequence

<220>
<223> DV07 Ebo EGF

<400> 19
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Arg Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Asn Tyr Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Ile Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro 
    210                 215                 220                 


Phe Thr Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
225                 230                 235                 240 


Ser Leu Gln Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Thr Ser Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Trp Gly Lys Gly 
            260                 265                 270         


Thr Thr Val Thr Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser 
    290                 295                 300                 


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
305                 310                 315                 320 


Ile Gly Thr Asn Ile His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
                325                 330                 335     


Arg Leu Leu Ile Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Phe Pro Asp 
            340                 345                 350         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr 
        355                 360                 365             


Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Asn Asn 
    370                 375                 380                 


Asn Trp Pro Thr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp 
                405                 410                 415     


Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp Ala Phe 
            420                 425                 430         


Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp Asn Leu 
        435                 440                 445             


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
    450                 455                 460                 


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
465                 470                 475                 480 


Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn Ser Leu 
                485                 490                 495     


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
            500                 505                 510         


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile Lys Asn 
        515                 520                 525             


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
    530                 535                 540                 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile Lys Ala 
545                 550                 555                 560 


Arg 
    


<210> 20
<211> 581
<212> PRT
<213> Artificial Sequence


<220>
<223> DV06 EboX

<220>
<221> MOD_RES
<222> (193)..(199)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (193)..(199)
<223> This region may encompass 3-7 residues

<220>
<221> MOD_RES
<222> (214)..(231)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (214)..(231)
<223> This region may encompass 14-18 residues

<220>
<221> MOD_RES
<222> (264)..(274)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (264)..(274)
<223> This region may encompass 7-11 residues

<220>
<221> MOD_RES
<222> (329)..(342)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (329)..(342)
<223> This region may encompass 9-14 residues

<220>
<221> MOD_RES
<222> (358)..(366)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (358)..(366)
<223> This region may encompass 5-9 residues

<220>
<221> MOD_RES
<222> (399)..(409)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (399)..(409)
<223> This region may encompass 7-11 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 20
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Val Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln Pro Pro Gly Lys Gly 
        195                 200                 205             


Leu Glu Trp Ile Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Ala Ile Ser Val Asp Thr Ser 
225                 230                 235                 240 


Lys Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Thr Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Trp Lys Gly Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        275                 280                 285             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
305                 310                 315                 320 


Gly Glu Arg Ala Thr Leu Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
            340                 345                 350         


Arg Leu Leu Ile Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Phe 
        355                 360                 365             


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    370                 375                 380                 


Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Gly Gln Gly Thr Lys Leu 
                405                 410                 415     


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu 
        435                 440                 445             


Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu 
    450                 455                 460                 


Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly 
465                 470                 475                 480 


Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu 
                485                 490                 495     


Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His 
            500                 505                 510         


Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg 
        515                 520                 525             


Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu 
    530                 535                 540                 


Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys 
545                 550                 555                 560 


Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met 
                565                 570                 575     


Thr Ile Lys Ala Arg 
            580     



<210> 21
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<223> DV06 Ebo

<400> 21
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Val Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Thr Thr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Ile Gly Glu Val Asn Tyr Ser Gly Asn Ala Asn Tyr Asn Pro Ser 
    210                 215                 220                 


Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Thr Ser Arg Ile Arg Ser His Ile Ala Tyr Ser Trp Lys Gly Asp 
            260                 265                 270         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr 
    290                 295                 300                 


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
305                 310                 315                 320 


Ser Cys Arg Ala Ser Gln Ser Val Pro Arg Asn Tyr Ile Gly Trp Phe 
                325                 330                 335     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
            340                 345                 350         


Ser Arg Ala Ala Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        355                 360                 365             


Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala 
    370                 375                 380                 


Met Tyr Tyr Cys His Gln Tyr Asp Arg Leu Pro Tyr Thr Phe Gly Gln 
385                 390                 395                 400 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met 
            420                 425                 430         


Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln 
        435                 440                 445             


Thr Lys Asp Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu 
    450                 455                 460                 


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln 
465                 470                 475                 480 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu 
                485                 490                 495     


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg 
            500                 505                 510         


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
        515                 520                 525             


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys 
    530                 535                 540                 


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
545                 550                 555                 560 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                565                 



<210> 22
<211> 575
<212> PRT
<213> Artificial Sequence

<220>
<223> DV06 MadCam

<400> 22
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Val Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
                165                 170                 175     


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            180                 185                 190         


Ser Tyr Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        195                 200                 205             


Trp Met Gly Trp Ile Ser Val Tyr Ser Gly Asn Thr Asn Tyr Ala Gln 
    210                 215                 220                 


Lys Val Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr 
225                 230                 235                 240 


Ala Tyr Met Asp Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr 
                245                 250                 255     


Tyr Cys Ala Arg Glu Gly Ser Ser Ser Ser Gly Asp Tyr Tyr Tyr Gly 
            260                 265                 270         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
    290                 295                 300                 


Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala 
305                 310                 315                 320 


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Thr Asp Gly Thr 
                325                 330                 335     


Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu 
            340                 345                 350         


Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
        355                 360                 365             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
    370                 375                 380                 


Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Asn Ile Gln Leu 
385                 390                 395                 400 


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys 
            420                 425                 430         


Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
        435                 440                 445             


Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Val Asp Asn Leu Leu Leu 
    450                 455                 460                 


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
465                 470                 475                 480 


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
                485                 490                 495     


Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn Ser Leu Gly Glu 
            500                 505                 510         


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
        515                 520                 525             


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe 
    530                 535                 540                 


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
545                 550                 555                 560 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                565                 570                 575 


<210> 23
<211> 573
<212> PRT
<213> Artificial Sequence

<220>
<223> DV07 EboX


<220>
<221> MOD_RES
<222> (193)..(199)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (193)..(199)
<223> This region may encompass 3-7 residues

<220>
<221> MOD_RES
<222> (213)..(230)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (213)..(230)
<223> This region may encompass 14-18 residues

<220>
<221> MOD_RES
<222> (263)..(273)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (263)..(273)
<223> This region may encompass 7-11 residues

<220>
<221> MOD_RES
<222> (321)..(334)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (321)..(334)
<223> This region may encompass 9-14 residues

<220>
<221> MOD_RES
<222> (350)..(358)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (350)..(358)
<223> This region may encompass 5-9 residues

<220>
<221> MOD_RES
<222> (391)..(401)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (391)..(401)
<223> This region may encompass 7-11 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 23
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Arg Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln Pro Pro Gly Lys Gly 
        195                 200                 205             


Leu Glu Trp Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
225                 230                 235                 240 


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Ala Ala Asp Thr Ala 
                245                 250                 255     


Ile Tyr Tyr Cys Thr Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Trp Gly Lys Gly Thr Thr Val Thr Val Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser 
    290                 295                 300                 


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Phe 
                325                 330                 335     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly 
        355                 360                 365             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp 
    370                 375                 380                 


Phe Ala Met Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn 
            420                 425                 430         


Phe Pro Gln Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys 
        435                 440                 445             


Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu 
    450                 455                 460                 


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
465                 470                 475                 480 


Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn 
                485                 490                 495     


Gln Asp Pro Glu Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu 
            500                 505                 510         


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
        515                 520                 525             


Glu Asn Lys Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys 
    530                 535                 540                 


Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe 
545                 550                 555                 560 


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                565                 570             


<210> 24
<211> 573
<212> PRT
<213> Artificial Sequence

<220>
<223> DV05 EboX


<220>
<221> MOD_RES
<222> (193)..(199)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (193)..(199)
<223> This region may encompass 3-7 residues

<220>
<221> MOD_RES
<222> (213)..(230)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (213)..(230)
<223> This region may encompass 14-18 residues

<220>
<221> MOD_RES
<222> (263)..(273)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (263)..(273)
<223> This region may encompass 7-11 residues

<220>
<221> MOD_RES
<222> (321)..(334)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (321)..(334)
<223> This region may encompass 9-14 residues

<220>
<221> MOD_RES
<222> (350)..(358)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (350)..(358)
<223> This region may encompass 5-9 residues

<220>
<221> MOD_RES
<222> (391)..(401)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (391)..(401)
<223> This region may encompass 7-11 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 24
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ala Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Arg Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln Pro Pro Gly Lys Gly 
        195                 200                 205             


Leu Glu Trp Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
225                 230                 235                 240 


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Ala Ala Asp Thr Ala 
                245                 250                 255     


Ile Tyr Tyr Cys Thr Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Trp Gly Lys Gly Thr Thr Val Thr Val Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser 
    290                 295                 300                 


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Phe 
                325                 330                 335     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly 
        355                 360                 365             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp 
    370                 375                 380                 


Phe Ala Met Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn 
            420                 425                 430         


Phe Pro Gln Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys 
        435                 440                 445             


Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu 
    450                 455                 460                 


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
465                 470                 475                 480 


Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn 
                485                 490                 495     


Gln Asp Pro Glu Ala Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu 
            500                 505                 510         


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
        515                 520                 525             


Glu Asn Lys Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys 
    530                 535                 540                 


Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe 
545                 550                 555                 560 


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                565                 570             


          
<210> 25
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<223> DV07 EboL3

<400> 25
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Thr Thr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Ile Gly Glu Val Asn Tyr Ser Gly Asn Ala Asn Tyr Asn Pro Ser 
    210                 215                 220                 


Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Thr Ser Arg Ile Arg Ser His Ile Ala Tyr Ser Trp Lys Gly Asp 
            260                 265                 270         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr  
    290                 295                 300                 


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu  
305                 310                 315                 320 


Ser Cys Arg Ala Ser Gln Ser Val Pro Arg Asn Tyr Ile Gly Trp Phe  
                325                 330                 335     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser  
            340                 345                 350         


Ser Arg Ala Ala Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly  
        355                 360                 365             


Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala  
    370                 375                 380                 


Met Tyr Tyr Cys His Gln Tyr Asp Arg Leu Pro Tyr Thr Phe Gly Gln  
385                 390                 395                 400 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly  
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met  
            420                 425                 430         


Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln  
        435                 440                 445             


Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu  
    450                 455                 460                 


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln  
465                 470                 475                 480 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu  
                485                 490                 495     


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg  
            500                 505                 510         


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser  
        515                 520                 525             


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys  
    530                 535                 540                 


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile  
545                 550                 555                 560 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                565         



<210> 26
<211> 563
<212> PRT
<213> Artificial Sequence

<220>
<223> DV07 EboEGFL3

<400> 26
Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Arg Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Asn Tyr Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Ile Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro 
    210                 215                 220                 


Phe Thr Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
225                 230                 235                 240 


Ser Leu Gln Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Thr Ser Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Trp Gly Lys Gly 
            260                 265                 270         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr  
    290                 295                 300                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser  
305                 310                 315                 320 


Gln Ser Ile Gly Thr Asn Ile His Trp Phe Gln Gln Lys Pro Gly Gln  
                325                 330                 335     


Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Phe  
            340                 345                 350         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr  
        355                 360                 365             


Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln  
    370                 375                 380                 


Asn Asn Asn Trp Pro Thr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile  
385                 390                 395                 400 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser  
                405                 410                 415     


Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp  
            420                 425                 430         


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp  
        435                 440                 445             


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu  
    450                 455                 460                 


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val  
465                 470                 475                 480 


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn  
                485                 490                 495     


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys  
            500                 505                 510         


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile  
        515                 520                 525             


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met  
    530                 535                 540                 


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile  
545                 550                 555                 560 


Lys Ala Arg



<210>  27
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEboegfrDV07 Variant 1 Amino Acid Sequence

<400>  27

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Thr 
            180                 185                 190         


Asn Tyr Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Ile Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Pro Ser 
    210                 215                 220                 


Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly 
            260                 265                 270         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    290                 295                 300                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
305                 310                 315                 320 


Ala Ser Gln Ser Ile Gly Thr Asn Ile Gly Trp Phe Gln Gln Lys Pro 
                325                 330                 335     


Gly Gln Ala Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Arg Ala Ala 
            340                 345                 350         


Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        355                 360                 365             


Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys 
    370                 375                 380                 


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Gln Gly Thr Lys Leu 
385                 390                 395                 400 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu 
            420                 425                 430         


Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu 
        435                 440                 445             


Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly 
    450                 455                 460                 


Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu 
465                 470                 475                 480 


Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His 
                485                 490                 495     


Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg 
            500                 505                 510         


Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu 
        515                 520                 525             


Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys 
    530                 535                 540                 


Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met 
545                 550                 555                 560 


Thr Ile Lys Ala Arg 
                565 


<210>  28
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DEboegfrDV07 Variant 1 Nucleic Acid Sequence

<400>  28
accgaccagt gcgacaactt ccctcagatg ctgcgggacc tgagagatgc cttctccaga       60

gtgaaaacat tcttccagac caaggacgag ctggacaacc tgctgctgaa agagtccctg      120

ctggaagatt tcaagggcta cctgggctgt caggccctgt ccgagatgat ccagttctac      180

ctggaagaag tgatgcccca ggccgagaat caggaccccg agatcaagga ccacgtgaac      240

tccctgggcg agaacctgaa aaccctgcgg ctgagactgc ggcggtgcca cagatttctg      300

ccctgcgaga acaagtccaa ggccgtggaa cagatcaaga acgccttcaa caagctgcaa      360

gagaagggca tctacaaggc catgagcgag ttcgacatct tcatcaacta catcgaggcc      420

tacatgacca tcaaggccag aggcggcgga ggatctggcg gaggtggaag cggaggcggt      480

ggatctcagg ttcagttgca gcaatggggc gctggcctgc tgaagccttc tgagacactg      540

tctctgacct gcgccgtgtc cggcttctct ctgaccaatt acggcgtgaa ctggattcgg      600

cagcctcctg gcaaaggcct ggaatggatc ggagtgattt ggagcggcgg caacaccgac      660

tacaacccca gtctgaaggg cagagtggcc atctccgtgg acacctccaa gaaccagttc      720

tccctgagac tgaactccgt gaccgccgct gataccgcca tctactactg tgctagagcc      780

ctgacctact acgactacga gttcgcctat tggggcaagg gcaccaccgt gactgttagt      840

agtggtggtg gcggtagtgg cggaggcggc tcaggcggtg gtggatctga aatcgtgatg      900

acccagtctc ctggcactct gtctctgtct cccggcgaga gagctaccct gtcttgtaga      960

gcctctcagt ccatcggcac caacatcggc tggttccagc agaagcctgg acaggctccc     1020

cggctgctga ttaagtacgc ctctgagaga gccgctggct tccctgacag attctccggc     1080

tctggctctg gcaccgactt caccctgacc atcaccagac tggaacccga ggacttcgct     1140

atgtactact gccagcagaa caacaactgg cccaccacct ttggccaggg caccaagctg     1200

gaaatcaaag gtggcggtgg ttcaggtggc ggaggaagcg gcggaggcgg atctacagat     1260

cagtgtgaca attttcccca aatgctgagg gatctgcggg acgccttcag ccgggtcaag     1320

acattttttc agacaaagga tgaactcgat aacctcttgc tcaaagagag cctgctcgag     1380

gactttaagg gatatctggg atgccaggct ctgagcgaaa tgattcagtt ttatctcgag     1440

gaagtcatgc ctcaagcaga gaaccaggat ccagagatta aggatcatgt gaatagcctc     1500

ggggagaacc tcaagacact gagactccgg ctgagaagat gccaccggtt tctgccttgt     1560

gaaaacaaaa gcaaggctgt cgagcagatt aagaatgctt ttaacaaact ccaagaaaaa     1620

gggatctata aggctatgtc tgagtttgat atctttatca attatatcga agcttatatg     1680

actattaagg cccggtag                                                   1698



<210>  29
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEboegfrDV07 Variant 2 Amino Acid Sequence

<400>  29

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Phe Ser Leu Thr 
            180                 185                 190         


Asn Tyr Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Ile Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro 
    210                 215                 220                 


Phe Thr Ser Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Thr Ser Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly 
            260                 265                 270         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    290                 295                 300                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
305                 310                 315                 320 


Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Phe Gln Gln Lys Pro 
                325                 330                 335     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Glu Ser Ile Ser 
            340                 345                 350         


Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        355                 360                 365             


Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys 
    370                 375                 380                 


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Gln Gly Thr Lys Leu 
385                 390                 395                 400 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu 
            420                 425                 430         


Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu 
        435                 440                 445             


Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly 
    450                 455                 460                 


Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu 
465                 470                 475                 480 


Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His 
                485                 490                 495     


Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg 
            500                 505                 510         


Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu 
        515                 520                 525             


Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys 
    530                 535                 540                 


Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met 
545                 550                 555                 560 


Thr Ile Lys Ala Arg 
                565 


<210>  30
<211>  1770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DEboegfrDV07 Variant 2 Nucleic Acid Sequence

<400>  30
gctagcgccg ccaccatggg atggtctttg atcctgctgt tcctggtggc cgtggctacc       60

agagtgcatt ctaccgacca gtgcgacaac ttccctcaga tgctgcggga cctgagagat      120

gccttctcca gagtgaaaac attcttccag accaaggacg agctggacaa cctgctgctg      180

aaagagtccc tgctggaaga tttcaagggc tacctgggct gtcaggccct gtccgagatg      240

atccagttct acctggaaga agtgatgccc caggccgaga atcaggaccc cgagatcaag      300

gaccacgtga actccctggg cgagaacctg aaaaccctgc ggctgagact gcggcggtgc      360

cacagatttc tgccctgcga gaacaagtcc aaggccgtgg aacagatcaa gaacgccttc      420

aacaagctgc aagagaaggg catctacaag gccatgagcg agttcgacat cttcatcaac      480

tacatcgagg cctacatgac catcaaggcc agaggcggcg gaggatctgg cggaggtgga      540

agcggaggcg gtggatctca ggttcagttg cagcaatggg gcgctggcct gctgaagcct      600

tctgagacac tgtctctgac ctgcgccgtg tacggcttct ccctgaccaa ttatggcgtg      660

cactggatca gacagcctcc aggcaaaggc ctggaatgga tcggagtgat ttggagcggc      720

ggcaacaccg actacaacac ccctttcacc tctagagtgg ccatctccgt ggacacctcc      780

aagaaccagt tcagcctgag actgaactcc gtgaccgccg ctgataccgc catctactac      840

tgcacctccg ctctgaccta ctacgactac gagttcgcct actggggcaa gggcaccaca      900

gtgactgtta gtagtggtgg cggaggtagc ggtggtggtg gtagtggcgg tggcggatct      960

gagatcgtga tgacccaatc tcctggcact ctgtctctgt ctcccggcga gagagctacc     1020

ctgtcttgta gagcctctca gtccatcggc accaacatcc actggttcca gcagaagcct     1080

ggacaggccc ctagactgct gatctactac gcctccgaga gcatcagcgg cttccctgac     1140

agattctccg gctctggctc tggcaccgac ttcaccctga caatcacccg gctggaacct     1200

gaggacttcg ctatgtacta ctgccagcag aacaacaact ggcccaccac ctttggccag     1260

ggcaccaagc tggaaatcaa aggcggaggc ggcagtggcg gcggtggctc cggcggaggc     1320

ggatctacag atcagtgtga caattttccc caaatgctga gggatctgcg ggacgccttc     1380

agccgggtca agacattttt tcagacaaag gatgaactcg ataacctctt gctcaaagag     1440

agcctgctcg aggacttcaa aggatatctg ggatgccagg ctctgagcga aatgattcag     1500

ttttatctcg aggaagtcat gccacaagca gagaaccagg atccagagat taaggatcat     1560

gtgaatagcc tcggggagaa cctcaagaca ctgagactcc ggctgagaag atgccaccgg     1620

tttctgcctt gtgaaaacaa aagcaaggct gtcgagcaga ttaagaatgc ttttaacaaa     1680

ctccaagaaa aagggatcta taaggctatg tctgagtttg atatctttat caattatatc     1740

gaagcttata tgactattaa ggcccggtag                                      1770


<210>  31
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEboegfrDV07 Variant 3 (SLP) Amino Acid Sequence

<400>  31

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Phe Ser Leu Thr 
            180                 185                 190         


Asn Tyr Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro 
    210                 215                 220                 


Phe Thr Ser Arg Val Ala Ile Ser Lys Asp Asn Ser Lys Asn Gln Val 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly 
            260                 265                 270         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    290                 295                 300                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
305                 310                 315                 320 


Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro 
                325                 330                 335     


Gly Gln Ala Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
            340                 345                 350         


Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        355                 360                 365             


Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys 
    370                 375                 380                 


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Gln Gly Thr Lys Leu 
385                 390                 395                 400 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu 
            420                 425                 430         


Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu 
        435                 440                 445             


Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly 
    450                 455                 460                 


Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu 
465                 470                 475                 480 


Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His 
                485                 490                 495     


Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg 
            500                 505                 510         


Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu 
        515                 520                 525             


Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys 
    530                 535                 540                 


Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met 
545                 550                 555                 560 


Thr Ile Lys Ala Arg 
                565 


<210>  32
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DEboegfrDV07 Variant 3 (SLP) Nucleic Acid Sequence

<400>  32
accgaccagt gcgacaactt ccctcagatg ctgcgggacc tgagagatgc cttctccaga       60

gtgaaaacat tcttccagac caaggacgag ctggacaacc tgctgctgaa agagtccctg      120

ctggaagatt tcaagggcta cctgggctgt caggccctgt ccgagatgat ccagttctac      180

ctggaagaag tgatgcccca ggccgagaat caggaccccg agatcaagga ccacgtgaac      240

tccctgggcg agaacctgaa aaccctgcgg ctgagactgc ggcggtgcca cagatttctg      300

ccctgcgaga acaagtccaa ggccgtggaa cagatcaaga acgccttcaa caagctgcaa      360

gagaagggca tctacaaggc catgagcgag ttcgacatct tcatcaacta catcgaggcc      420

tacatgacca tcaaggccag aggcggcgga ggatctggcg gaggtggaag cggaggcggt      480

ggatctcagg ttcagttgca gcaatggggc gctggcctgc tgaagccttc tgagacactg      540

tctctgacct gcgccgtgta cggcttctcc ctgaccaatt atggcgtgca ctggatcaga      600

cagcctccag gcaaaggcct ggaatggctg ggagtgattt ggagcggcgg caacaccgac      660

tacaacaccc ctttcacctc tagagtggcc atctccaagg acaactccaa gaaccaggtg      720

tccctgagac tgaactccgt gaccgctgcc gataccgcca tctactactg tgctagagcc      780

ctgacctact acgactacga gttcgcctat tggggcaagg gcaccaccgt gactgttagt      840

agtggtggtg gcggtagtgg cggaggcggc tcaggcggtg gtggatctga aattgtgctg      900

acccagtctc ctggcactct gtctttgagc cctggcgaga gagctaccct gtcctgtaga      960

gcctctcagt ccatcggcac caacatccac tggtatcagc agaagcctgg acaggcccct     1020

cggctgctga ttaagtacgc ctccgagtcc atcagcggct tccctgacag attctccggc     1080

tctggctctg gcaccgactt caccctgaca atcacccggc tggaacctga ggacttcgct     1140

atgtactact gccagcagaa caacaactgg cccaccacct ttggccaggg caccaagctg     1200

gaaatcaaag gtggcggtgg ttcaggtggc ggaggaagcg gcggaggcgg atctacagat     1260

cagtgtgaca attttcccca aatgctgagg gatctgcggg acgccttcag ccgggtcaag     1320

acattttttc agacaaagga tgaactcgat aacctcttgc tcaaagagag cctgctcgag     1380

gacttcaaag gatatctggg atgccaggct ctgagcgaaa tgattcagtt ttatctcgag     1440

gaagtcatgc ctcaagcaga gaaccaggat ccagagatta aggatcatgt gaatagcctc     1500

ggggagaacc tcaagacact gagactccgg ctgagaagat gccaccggtt tctgccttgt     1560

gaaaacaaaa gcaaggctgt cgagcagatt aagaatgctt ttaacaaatt gcaagaaaaa     1620

gggatctata aggctatgtc tgagtttgat atctttatca attatatcga agcttatatg     1680

actattaagg cccggtag                                                   1698


<210>  33
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEboegfrDV07 Variant 4 Amino Acid Sequence

<400>  33

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            180                 185                 190         


Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro 
    210                 215                 220                 


Phe Thr Ser Arg Val Ala Ile Ser Lys Asp Asn Ser Lys Asn Gln Val 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly 
            260                 265                 270         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    290                 295                 300                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
305                 310                 315                 320 


Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro 
                325                 330                 335     


Gly Gln Ala Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
            340                 345                 350         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        355                 360                 365             


Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Asp Tyr Tyr Cys 
    370                 375                 380                 


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Gln Gly Thr Lys Leu 
385                 390                 395                 400 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu 
            420                 425                 430         


Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu 
        435                 440                 445             


Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly 
    450                 455                 460                 


Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu 
465                 470                 475                 480 


Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His 
                485                 490                 495     


Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg 
            500                 505                 510         


Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu 
        515                 520                 525             


Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys 
    530                 535                 540                 


Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met 
545                 550                 555                 560 


Thr Ile Lys Ala Arg 
                565 


<210>  34
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DEboegfrDV07 Variant 4 Nucleic Acid Sequence

<400>  34
accgaccagt gcgacaactt ccctcagatg ctgcgggacc tgagagatgc cttctccaga       60

gtgaaaacat tcttccagac caaggacgag ctggacaacc tgctgctgaa agagtccctg      120

ctggaagatt tcaagggcta cctgggctgt caggccctgt ccgagatgat ccagttctac      180

ctggaagaag tgatgcccca ggccgagaat caggaccccg agatcaagga ccacgtgaac      240

tccctgggcg agaacctgaa aaccctgcgg ctgagactgc ggcggtgcca cagatttctg      300

ccctgcgaga acaagtccaa ggccgtggaa cagatcaaga acgccttcaa caagctgcaa      360

gagaagggca tctacaaggc catgagcgag ttcgacatct tcatcaacta catcgaggcc      420

tacatgacca tcaaggccag aggcggcgga ggatctggcg gaggtggaag cggaggcggt      480

ggatctcagg ttcagttgca gcaatggggc gctggcctgc tgaagccttc tgagacactg      540

tctctgacct gcaccgtgtc cggcttctcc ctgaccaatt atggcgtgca ctgggtccga      600

cagcctccag gcaaaggatt ggaatggctg ggagtgattt ggagcggcgg caacaccgac      660

tacaacaccc ctttcacctc tagagtggcc atctccaagg acaactccaa gaaccaggtg      720

tccctgagac tgaactccgt gaccgctgcc gataccgcca tctactactg tgctagagcc      780

ctgacctact acgactacga gttcgcctat tggggcaagg gcaccaccgt gactgttagt      840

agtggtggtg gcggtagtgg cggaggcggc tcaggcggtg gtggatctga aattgtgctg      900

acccagtctc ctggcactct gtctttgagc cctggcgaga gagctaccct gtcctgtaga      960

gcctctcagt ccatcggcac caacatccac tggtatcagc agaagcctgg acaggcccct     1020

cggctgctga ttaagtacgc ctccgagtcc atcagcggca tccctgacag attctccggc     1080

tctggctctg gcaccgactt caccctgaca atcacccggc tggaacctga ggacttcgcc     1140

gactactact gccagcagaa caacaactgg cccaccacct ttggccaggg caccaagctg     1200

gaaatcaaag gtggcggtgg ttcaggtggc ggaggaagcg gcggaggcgg atctacagat     1260

cagtgtgaca attttcccca aatgctgagg gatctgcggg acgccttcag ccgggtcaag     1320

acattttttc agacaaagga tgaactcgat aacctcttgc tcaaagagag cctgctcgag     1380

gacttcaaag gatatctggg atgccaggct ctgagcgaaa tgattcagtt ttatctcgag     1440

gaagtcatgc ctcaagcaga gaaccaggat ccagagatta aggatcatgt gaatagcctc     1500

ggggagaacc tcaagacact gagactccgg ctgagaagat gccaccggtt tctgccttgt     1560

gaaaacaaaa gcaaggctgt cgagcagatt aagaatgctt ttaacaaatt gcaagaaaaa     1620

gggatctata aggctatgtc tgagtttgat atctttatca attatatcga agcttatatg     1680

actattaagg cccgg                                                      1695



<210>  35
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK210egfr Amino Acid Sequence

<400>  35

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Phe Ser Leu Thr 
            180                 185                 190         


Asn Tyr Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro 
    210                 215                 220                 


Phe Thr Ser Arg Val Ala Ile Ser Lys Asp Asn Ser Lys Asn Gln Val 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly 
            260                 265                 270         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys 
    290                 295                 300                 


Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile 
305                 310                 315                 320 


Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu 
                325                 330                 335     


Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu 
            340                 345                 350         


Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu 
        355                 360                 365             


Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn 
    370                 375                 380                 


Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met 
385                 390                 395                 400 


Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg 
                405                 410                 415     


Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
        435                 440                 445             


Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
    450                 455                 460                 


Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr 
465                 470                 475                 480 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Lys Tyr Ala Ser 
                485                 490                 495     


Glu Ser Ile Ser Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            500                 505                 510         


Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala 
        515                 520                 525             


Met Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Gln 
    530                 535                 540                 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met 
                565                 570                 575     


Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln 
            580                 585                 590         


Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu 
        595                 600                 605             


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln 
    610                 615                 620                 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu 
625                 630                 635                 640 


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg 
                645                 650                 655     


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
            660                 665                 670         


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys 
        675                 680                 685             


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
    690                 695                 700                 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
705                 710             


<210>  36
<211>  133
<212>  PRT
<213>  Homo sapiens IL-2

<400>  36

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified VH region of anti-EGFR antibody

<400>  37

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Val Ala Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified VL region of anti-EGFR antibody

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Phe Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105   


<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Sequence Linker 1

<400> 39
Ser Ser Gly Gly Gly Gly Ser 
1               5           


<210> 40
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Sequence Linker 2

<400> 40
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  



<210> 41
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Sequence Linker 3

<400> 41
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  



<210> 42
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Sequence 6xHis tag

<400> 42
His His His His His His 
1               5       


                     
<210>  43
<211>  129
<212>  PRT
<213>  Homo sapiens

<220>
<223> Human IL-4 Amino Acid Sequence

<400>  43

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  44
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIL4 (N38A)

<400>  44

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Ala Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  45
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIL4 (T13D)

<400>  45

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Asp Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Ala Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  46
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410DV06 (non targeting)

<400>  46

Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp Leu Arg Asp 
1               5                   10                  15      


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Val Asp 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
        35                  40                  45              


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
    50                  55                  60                  


Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp His Val Asn 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
                85                  90                  95      


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Ile 
            100                 105                 110         


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
        115                 120                 125             


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile 
    130                 135                 140                 


Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
                165                 170                 175     


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Thr 
            180                 185                 190         


Thr Thr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        195                 200                 205             


Trp Ile Gly Glu Val Asn Tyr Ser Gly Asn Ala Asn Tyr Asn Pro Ser 
    210                 215                 220                 


Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
225                 230                 235                 240 


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                245                 250                 255     


Cys Thr Ser Arg Ile Arg Ser His Ile Ala Tyr Ser Trp Lys Gly Asp 
            260                 265                 270         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile 
    290                 295                 300                 


Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys 
305                 310                 315                 320 


Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys 
                325                 330                 335     


Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg 
            340                 345                 350         


Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr 
        355                 360                 365             


Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg 
    370                 375                 380                 


Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val 
385                 390                 395                 400 


Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys 
                405                 410                 415     


Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly 
            420                 425                 430         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr 
        435                 440                 445             


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    450                 455                 460                 


Ser Cys Arg Ala Ser Gln Ser Val Pro Arg Asn Tyr Ile Gly Trp Phe 
465                 470                 475                 480 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
                485                 490                 495     


Ser Arg Ala Ala Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            500                 505                 510         


Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala 
        515                 520                 525             


Met Tyr Tyr Cys His Gln Tyr Asp Arg Leu Pro Tyr Thr Phe Gly Gln 
    530                 535                 540                 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met 
                565                 570                 575     


Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln 
            580                 585                 590         


Thr Lys Asp Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu 
        595                 600                 605             


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln 
    610                 615                 620                 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu 
625                 630                 635                 640 


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg 
                645                 650                 655     


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
            660                 665                 670         


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys 
        675                 680                 685             


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
    690                 695                 700                 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
705                 710             


<210>  47
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410HADeglyDV06mCD14

<400>  47

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe 
        195                 200                 205             


Ser Leu Thr Thr Tyr Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Ile Gly Phe Ile Arg Ser Gly Gly Ser Thr Glu Tyr 
225                 230                 235                 240 


Asn Pro Ser Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys 
                245                 250                 255     


Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala 
            260                 265                 270         


Ile Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Asn Phe Asp Tyr Trp Gly 
        275                 280                 285             


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln 
305                 310                 315                 320 


Glu Ile Ile Lys Asp Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
                325                 330                 335     


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr 
            340                 345                 350         


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
        355                 360                 365             


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
    370                 375                 380                 


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
385                 390                 395                 400 


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
                405                 410                 415     


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
            420                 425                 430         


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    450                 455                 460                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
465                 470                 475                 480 


Ala Ser Gln Ser Leu Val His Ser Asn Gly Lys Thr Tyr Val Gly Trp 
                485                 490                 495     


Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Val 
            500                 505                 510         


Ser Asn Arg Ala Ala Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Met Tyr Tyr Cys Leu Gln Ser Thr His Phe Pro Arg Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln 
            580                 585                 590         


Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe 
        595                 600                 605             


Gln Thr Lys Asp Glu Val Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu 
    610                 615                 620                 


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln 
625                 630                 635                 640 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu 
                645                 650                 655     


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg 
            660                 665                 670         


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
        675                 680                 685             


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys 
    690                 695                 700                 


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
705                 710                 715                 720 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 


<210>  48
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410HADeglyDV07mCD14

<400>  48

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe 
        195                 200                 205             


Ser Leu Thr Thr Tyr Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Ile Gly Phe Ile Arg Ser Gly Gly Ser Thr Glu Tyr 
225                 230                 235                 240 


Asn Pro Ser Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys 
                245                 250                 255     


Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala 
            260                 265                 270         


Ile Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Asn Phe Asp Tyr Trp Gly 
        275                 280                 285             


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln 
305                 310                 315                 320 


Glu Ile Ile Lys Asp Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
                325                 330                 335     


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr 
            340                 345                 350         


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
        355                 360                 365             


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
    370                 375                 380                 


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
385                 390                 395                 400 


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
                405                 410                 415     


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
            420                 425                 430         


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    450                 455                 460                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
465                 470                 475                 480 


Ala Ser Gln Ser Leu Val His Ser Asn Gly Lys Thr Tyr Val Gly Trp 
                485                 490                 495     


Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Val 
            500                 505                 510         


Ser Asn Arg Ala Ala Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Met Tyr Tyr Cys Leu Gln Ser Thr His Phe Pro Arg Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln 
            580                 585                 590         


Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe 
        595                 600                 605             


Gln Thr Lys Asp Glu Leu Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu 
    610                 615                 620                 


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln 
625                 630                 635                 640 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu 
                645                 650                 655     


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg 
            660                 665                 670         


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
        675                 680                 685             


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys 
    690                 695                 700                 


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
705                 710                 715                 720 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 


<210>  49
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410ngDV06CmD14

<400>  49

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe 
        195                 200                 205             


Ser Leu Thr Thr Tyr Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Ile Gly Phe Ile Arg Ser Gly Gly Ser Thr Glu Tyr 
225                 230                 235                 240 


Asn Pro Ser Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys 
                245                 250                 255     


Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala 
            260                 265                 270         


Ile Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Asn Phe Asp Tyr Trp Gly 
        275                 280                 285             


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln 
305                 310                 315                 320 


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
                325                 330                 335     


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr 
            340                 345                 350         


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
        355                 360                 365             


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
    370                 375                 380                 


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
385                 390                 395                 400 


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
                405                 410                 415     


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
            420                 425                 430         


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    450                 455                 460                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
465                 470                 475                 480 


Ala Ser Gln Ser Leu Val His Ser Asn Gly Lys Thr Tyr Val Gly Trp 
                485                 490                 495     


Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Val 
            500                 505                 510         


Ser Asn Arg Ala Ala Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Met Tyr Tyr Cys Leu Gln Ser Thr His Phe Pro Arg Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln 
            580                 585                 590         


Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe 
        595                 600                 605             


Gln Thr Lys Asp Glu Val Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu 
    610                 615                 620                 


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln 
625                 630                 635                 640 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu 
                645                 650                 655     


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg 
            660                 665                 670         


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
        675                 680                 685             


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys 
    690                 695                 700                 


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
705                 710                 715                 720 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 


<210>  50
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410ngDV07CmD14

<400>  50

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe 
        195                 200                 205             


Ser Leu Thr Thr Tyr Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Ile Gly Phe Ile Arg Ser Gly Gly Ser Thr Glu Tyr 
225                 230                 235                 240 


Asn Pro Ser Leu Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser Lys 
                245                 250                 255     


Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala 
            260                 265                 270         


Ile Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Asn Phe Asp Tyr Trp Gly 
        275                 280                 285             


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln 
305                 310                 315                 320 


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
                325                 330                 335     


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr 
            340                 345                 350         


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
        355                 360                 365             


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
    370                 375                 380                 


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
385                 390                 395                 400 


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
                405                 410                 415     


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
            420                 425                 430         


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    450                 455                 460                 


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
465                 470                 475                 480 


Ala Ser Gln Ser Leu Val His Ser Asn Gly Lys Thr Tyr Val Gly Trp 
                485                 490                 495     


Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Val 
            500                 505                 510         


Ser Asn Arg Ala Ala Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Met Tyr Tyr Cys Leu Gln Ser Thr His Phe Pro Arg Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln 
            580                 585                 590         


Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe 
        595                 600                 605             


Gln Thr Lys Asp Glu Leu Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu 
    610                 615                 620                 


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln 
625                 630                 635                 640 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu 
                645                 650                 655     


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg 
            660                 665                 670         


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
        675                 680                 685             


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys 
    690                 695                 700                 


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
705                 710                 715                 720 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 


<210>  51
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410ngDV06mMAdCAM

<400>  51

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Phe 
        195                 200                 205             


Thr Phe Thr Asp Phe Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Ile Gly Leu Ile Arg Asn Lys Ala Asn Ala Tyr Thr 
225                 230                 235                 240 


Thr Glu Tyr Asn Pro Ser Val Lys Gly Arg Val Ala Ile Ser Val Asp 
                245                 250                 255     


Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala 
            260                 265                 270         


Asp Thr Ala Ile Tyr Tyr Cys Thr Ser Asp Asp His Trp Gly Lys Gly 
        275                 280                 285             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile 
305                 310                 315                 320 


Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu 
                325                 330                 335     


Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr Glu Lys 
            340                 345                 350         


Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His 
        355                 360                 365             


His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His 
    370                 375                 380                 


Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu 
385                 390                 395                 400 


Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln 
                405                 410                 415     


Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu 
            420                 425                 430         


Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Gly Thr 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser 
465                 470                 475                 480 


Gln Ser Leu Leu Tyr Asn Glu Asn Lys Lys Asn Tyr Leu Ala Trp Phe 
                485                 490                 495     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser 
            500                 505                 510         


Thr Arg Glu Ser Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        515                 520                 525             


Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala 
    530                 535                 540                 


Met Tyr Tyr Cys Gln Gln Tyr Tyr Asn Phe Pro Tyr Thr Phe Gly Gln 
545                 550                 555                 560 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met 
            580                 585                 590         


Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln 
        595                 600                 605             


Thr Lys Asp Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu 
    610                 615                 620                 


Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln 
625                 630                 635                 640 


Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu 
                645                 650                 655     


Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg 
            660                 665                 670         


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
        675                 680                 685             


Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys 
    690                 695                 700                 


Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
705                 710                 715                 720 


Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 


<210>  52
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK210her2 (Variant 2)

<400>  52

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Phe 
        195                 200                 205             


Asn Ile Lys Asp Thr Tyr Ile His Trp Ile Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg 
225                 230                 235                 240 


Tyr Ala Asp Ser Val Lys Gly Arg Val Ala Ile Ser Val Asp Thr Ser 
                245                 250                 255     


Lys Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr 
            260                 265                 270         


Ala Ile Tyr Tyr Cys Thr Ser Trp Gly Gly Asp Gly Phe Tyr Ala Met 
        275                 280                 285             


Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser 
305                 310                 315                 320 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                325                 330                 335     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            340                 345                 350         


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
        355                 360                 365             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    370                 375                 380                 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
385                 390                 395                 400 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                405                 410                 415     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            420                 425                 430         


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
        435                 440                 445             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
                485                 490                 495     


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
            500                 505                 510         


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Phe Pro Asp Arg Phe Ser Gly 
        515                 520                 525             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro 
    530                 535                 540                 


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
545                 550                 555                 560 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn 
            580                 585                 590         


Phe Pro Gln Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys 
        595                 600                 605             


Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu 
    610                 615                 620                 


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
625                 630                 635                 640 


Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn 
                645                 650                 655     


Gln Asp Pro Glu Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu 
            660                 665                 670         


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
        675                 680                 685             


Glu Asn Lys Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys 
    690                 695                 700                 


Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe 
705                 710                 715                 720 


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 730             


<210>  53
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK210her2 (Variant 3)

<400>  53

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Phe 
        195                 200                 205             


Asn Ile Lys Asp Thr Tyr Ile His Trp Ile Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg 
225                 230                 235                 240 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Ala Asp Thr Ser 
                245                 250                 255     


Lys Asn Gln Ala Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr 
            260                 265                 270         


Ala Ile Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met 
        275                 280                 285             


Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser 
305                 310                 315                 320 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                325                 330                 335     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            340                 345                 350         


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
        355                 360                 365             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    370                 375                 380                 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
385                 390                 395                 400 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                405                 410                 415     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            420                 425                 430         


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
        435                 440                 445             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
                485                 490                 495     


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
            500                 505                 510         


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Phe Pro Asp Arg Phe Ser Gly 
        515                 520                 525             


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro 
    530                 535                 540                 


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
545                 550                 555                 560 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn 
            580                 585                 590         


Phe Pro Gln Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys 
        595                 600                 605             


Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu 
    610                 615                 620                 


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
625                 630                 635                 640 


Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn 
                645                 650                 655     


Gln Asp Pro Glu Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu 
            660                 665                 670         


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
        675                 680                 685             


Glu Asn Lys Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys 
    690                 695                 700                 


Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe 
705                 710                 715                 720 


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 730             


<210>  54
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK210her2 (Variant 4)

<400>  54

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Ala Ser Gly Phe 
        195                 200                 205             


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg 
225                 230                 235                 240 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Ala Asp Thr Ser 
                245                 250                 255     


Lys Asn Gln Ala Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr 
            260                 265                 270         


Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met 
        275                 280                 285             


Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser 
305                 310                 315                 320 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                325                 330                 335     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            340                 345                 350         


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
        355                 360                 365             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    370                 375                 380                 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
385                 390                 395                 400 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                405                 410                 415     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            420                 425                 430         


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
        435                 440                 445             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
                485                 490                 495     


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
            500                 505                 510         


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
        515                 520                 525             


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro 
    530                 535                 540                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
545                 550                 555                 560 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn 
            580                 585                 590         


Phe Pro Gln Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys 
        595                 600                 605             


Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu 
    610                 615                 620                 


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
625                 630                 635                 640 


Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn 
                645                 650                 655     


Gln Asp Pro Glu Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu 
            660                 665                 670         


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
        675                 680                 685             


Glu Asn Lys Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys 
    690                 695                 700                 


Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe 
705                 710                 715                 720 


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 730             


<210>  55
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK210her2 (Variant 5)

<400>  55

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Ala Ser Gly Phe 
        195                 200                 205             


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Pro Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg 
225                 230                 235                 240 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Ala Asp Thr Ser 
                245                 250                 255     


Lys Asn Gln Ala Ser Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            260                 265                 270         


Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met 
        275                 280                 285             


Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser 
305                 310                 315                 320 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                325                 330                 335     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            340                 345                 350         


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
        355                 360                 365             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    370                 375                 380                 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
385                 390                 395                 400 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                405                 410                 415     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            420                 425                 430         


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
        435                 440                 445             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
                485                 490                 495     


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
            500                 505                 510         


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
        515                 520                 525             


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    530                 535                 540                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
545                 550                 555                 560 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn 
            580                 585                 590         


Phe Pro Gln Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys 
        595                 600                 605             


Thr Phe Phe Gln Thr Lys Asp Glu Leu Asp Asn Leu Leu Leu Lys Glu 
    610                 615                 620                 


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
625                 630                 635                 640 


Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn 
                645                 650                 655     


Gln Asp Pro Glu Ile Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu 
            660                 665                 670         


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
        675                 680                 685             


Glu Asn Lys Ser Lys Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys 
    690                 695                 700                 


Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe 
705                 710                 715                 720 


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Ile Lys Ala Arg 
                725                 730             


<210>  56
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410ngDV06CD14 (Variant 2)

<400>  56

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Tyr 
        195                 200                 205             


Ser Ile Thr Ser Asp Ser Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly 
    210                 215                 220                 


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser 
225                 230                 235                 240 


Tyr Asn Pro Ser Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser 
                245                 250                 255     


Lys Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr 
            260                 265                 270         


Ala Ile Tyr Tyr Cys Thr Ser Gly Leu Arg Phe Ala Tyr Trp Gly Lys 
        275                 280                 285             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu 
305                 310                 315                 320 


Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr 
                325                 330                 335     


Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr Glu 
            340                 345                 350         


Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser 
        355                 360                 365             


His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe 
    370                 375                 380                 


His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn 
385                 390                 395                 400 


Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn 
                405                 410                 415     


Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg 
            420                 425                 430         


Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Gly 
    450                 455                 460                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
465                 470                 475                 480 


Ser Glu Ser Val Asp Ser Tyr Val Asn Ser Phe Leu His Trp Phe Gln 
                485                 490                 495     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn 
            500                 505                 510         


Leu Gln Ser Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        515                 520                 525             


Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Met 
    530                 535                 540                 


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Thr Thr Phe Gly Gln Gly 
545                 550                 555                 560 


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu 
            580                 585                 590         


Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr 
        595                 600                 605             


Lys Asp Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp 
    610                 615                 620                 


Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe 
625                 630                 635                 640 


Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile 
                645                 650                 655     


Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu 
            660                 665                 670         


Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys 
        675                 680                 685             


Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly 
    690                 695                 700                 


Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu 
705                 710                 715                 720 


Ala Tyr Met Thr Ile Lys Ala Arg 
                725             


<210>  57
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410ngDV06CD14 (Variant 3)

<400>  57

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Tyr 
        195                 200                 205             


Ser Ile Thr Ser Asp Ser Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly 
    210                 215                 220                 


Lys Gly Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser 
225                 230                 235                 240 


Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ala Ile Ser Arg Asp Thr Ser 
                245                 250                 255     


Lys Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr 
            260                 265                 270         


Ala Ile Tyr Tyr Cys Val Arg Gly Leu Arg Phe Ala Tyr Trp Gly Lys 
        275                 280                 285             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu 
305                 310                 315                 320 


Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr 
                325                 330                 335     


Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr Glu 
            340                 345                 350         


Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser 
        355                 360                 365             


His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe 
    370                 375                 380                 


His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn 
385                 390                 395                 400 


Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn 
                405                 410                 415     


Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg 
            420                 425                 430         


Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    450                 455                 460                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
465                 470                 475                 480 


Ser Glu Ser Val Asp Ser Tyr Val Asn Ser Phe Leu His Trp Tyr Gln 
                485                 490                 495     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn 
            500                 505                 510         


Leu Gln Ser Gly Phe Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr 
        515                 520                 525             


Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Met 
    530                 535                 540                 


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Thr Thr Phe Gly Gln Gly 
545                 550                 555                 560 


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu 
            580                 585                 590         


Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr 
        595                 600                 605             


Lys Asp Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp 
    610                 615                 620                 


Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe 
625                 630                 635                 640 


Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile 
                645                 650                 655     


Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu 
            660                 665                 670         


Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys 
        675                 680                 685             


Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly 
    690                 695                 700                 


Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu 
705                 710                 715                 720 


Ala Tyr Met Thr Ile Lys Ala Arg 
                725             


<210>  58
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410ngDV06CD14 (Variant 4)

<400>  58

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr 
        195                 200                 205             


Ser Ile Thr Ser Asp Ser Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly 
    210                 215                 220                 


Lys Gly Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser 
225                 230                 235                 240 


Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ala Ile Ser Arg Asp Thr Ser 
                245                 250                 255     


Lys Asn Gln Phe Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr 
            260                 265                 270         


Ala Thr Tyr Tyr Cys Val Arg Gly Leu Arg Phe Ala Tyr Trp Gly Lys 
        275                 280                 285             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu 
305                 310                 315                 320 


Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr 
                325                 330                 335     


Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr Glu 
            340                 345                 350         


Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser 
        355                 360                 365             


His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe 
    370                 375                 380                 


His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn 
385                 390                 395                 400 


Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn 
                405                 410                 415     


Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg 
            420                 425                 430         


Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    450                 455                 460                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
465                 470                 475                 480 


Ser Glu Ser Val Asp Ser Tyr Val Asn Ser Phe Leu His Trp Tyr Gln 
                485                 490                 495     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn 
            500                 505                 510         


Leu Gln Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr 
        515                 520                 525             


Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro Glu Asp Phe Ala Thr 
    530                 535                 540                 


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Thr Thr Phe Gly Gln Gly 
545                 550                 555                 560 


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu 
            580                 585                 590         


Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr 
        595                 600                 605             


Lys Asp Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp 
    610                 615                 620                 


Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe 
625                 630                 635                 640 


Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile 
                645                 650                 655     


Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu 
            660                 665                 670         


Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys 
        675                 680                 685             


Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly 
    690                 695                 700                 


Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu 
705                 710                 715                 720 


Ala Tyr Met Thr Ile Lys Ala Arg 
                725             


<210>  59
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DK410ngDV06CD14 (Variant 5)

<400>  59

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu Arg Asp 
            20                  25                  30          


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr Lys Asp 
        35                  40                  45              


Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
    50                  55                  60                  


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
65                  70                  75                  80  


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile Lys Asp 
                85                  90                  95      


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
            100                 105                 110         


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
        115                 120                 125             


Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
    130                 135                 140                 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
145                 150                 155                 160 


Met Thr Ile Lys Ala Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            180                 185                 190         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr 
        195                 200                 205             


Ser Ile Thr Ser Asp Ser Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly 
    210                 215                 220                 


Lys Gly Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser 
225                 230                 235                 240 


Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ala Ile Ser Arg Asp Thr Ser 
                245                 250                 255     


Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr 
            260                 265                 270         


Ala Thr Tyr Tyr Cys Val Arg Gly Leu Arg Phe Ala Tyr Trp Gly Lys 
        275                 280                 285             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu 
305                 310                 315                 320 


Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr 
                325                 330                 335     


Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Ala Thr Thr Glu 
            340                 345                 350         


Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser 
        355                 360                 365             


His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe 
    370                 375                 380                 


His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn 
385                 390                 395                 400 


Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn 
                405                 410                 415     


Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg 
            420                 425                 430         


Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    450                 455                 460                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
465                 470                 475                 480 


Ser Glu Ser Val Asp Ser Tyr Val Asn Ser Phe Leu His Trp Tyr Gln 
                485                 490                 495     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn 
            500                 505                 510         


Leu Gln Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr 
        515                 520                 525             


Asp Phe Thr Leu Thr Ile Asn Arg Val Glu Pro Glu Asp Phe Ala Thr 
    530                 535                 540                 


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Thr Thr Phe Gly Gln Gly 
545                 550                 555                 560 


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Thr Asp Gln Cys Asp Asn Phe Pro Gln Met Leu 
            580                 585                 590         


Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Thr 
        595                 600                 605             


Lys Asp Glu Val Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp 
    610                 615                 620                 


Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe 
625                 630                 635                 640 


Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Glu Ile 
                645                 650                 655     


Lys Asp His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu 
            660                 665                 670         


Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys 
        675                 680                 685             


Ala Val Glu Gln Ile Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly 
    690                 695                 700                 


Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu 
705                 710                 715                 720 


Ala Tyr Met Thr Ile Lys Ala Arg 
                725             


<210>  60
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DK210egfr Nucleic Acid Sequence

<400>  60
gccgccacca tgggatggtc tttgatcctg ctgttcctgg tggccgtggc taccagagtg       60

cattctaccg accagtgcga caacttccct cagatgctgc gggacctgag ggacgccttc      120

tccagagtga aaacattctt ccagaccaag gacgagctgg acaacctgct gctgaaagag      180

tccctgctgg aagatttcaa gggctacctg ggctgtcagg ccctgtccga gatgatccag      240

ttctacctgg aagaagtgat gccccaggcc gagaatcagg accctgagat caaggaccat      300

gtgaactccc tgggcgagaa cctgaaaacc ctgcggctga gactgcggcg gtgtcacaga      360

tttctgccct gcgagaacaa gtccaaggcc gtggaacaga tcaagaacgc cttcaacaag      420

ctgcaagaga agggcatcta caaggccatg agcgagttcg acatcttcat caactacatc      480

gaggcctaca tgaccatcaa ggctagaggt ggcggaggat ctggcggtgg tggttctggc      540

ggaggcggat ctcaggttca gttgcaacaa tggggcgctg gcctgctgaa gccttctgag      600

acactgtctc tgacctgcgc cgtgtacggc ttctctctga ccaattacgg cgtgcactgg      660

atccggcagc cacctggaaa aggactggaa tggctgggag tgatttggag cggcggcaac      720

accgactaca acaccccttt tacctctaga gtggccatct ccaaggacaa ctccaagaac      780

caggtgtccc tgagactgaa ctctgtgacc gccgctgata ccgccatcta ctactgtgct      840

agagccctga cctactacga ctacgagttc gcttattggg gcaagggcac caccgtgaca      900

gtttcatctg gcggcggagg aagcggtggc ggcggtagcg gaggtggtgg atctgctcct      960

acctcctcca gcaccaagaa aacccagctg cagttggagc atctgctgct ggacctccag     1020

atgatcctga acggcatcaa caactacaag aatcccaagc tgacccggat gctgaccttc     1080

aagttctaca tgcccaagaa ggccaccgag ctgaaacatc tgcagtgcct ggaagaggaa     1140

ctgaagcccc tcgaggaagt gctgaatctg gcccagtcca agaacttcca cctgaggcct     1200

agggacctga tctccaacat caacgtgatc gtgctcgagc tgaagggctc cgagacaacc     1260

tttatgtgcg agtacgccga cgagacagcc accatcgtgg aatttctgaa ccggtggatc     1320

accttctgcc agtccatcat ctctacattg accggtggtg gcggatcagg cggtggcgga     1380

agcggaggcg gaggttctga aattgtgctg acccagtctc ctggcactct gtctttgagt     1440

cctggcgaga gagctaccct gtcctgcaga gcttctcagt ccatcggcac caacatccac     1500

tggtatcagc agaagcctgg acaggcccct cggctgctga ttaagtacgc ctctgagtcc     1560

atcagcggct tccctgacag attctctggc tctggatctg gcaccgactt caccctgacc     1620

atcaccagac tggaacccga ggacttcgct atgtactact gccagcagaa caacaactgg     1680

cccaccacct ttggccaggg caccaagttg gaaatcaaag gtggcggtgg aagtggcggc     1740

ggtggctcag gcggcggtgg atctacagac cagtgtgata attttccaca gatgctcagg     1800

gatctccgcg acgcctttag ccgggtcaag acattttttc agacaaagga tgaactcgat     1860

aatctcctgc tcaaagagag cctgctcgag gactttaaag gatacctggg atgccaggct     1920

ctcagcgaaa tgattcagtt ttatttggag gaagtcatgc ctcaagctga aaaccaggat     1980

ccagagatta aggatcacgt caacagcctc ggcgagaatc tcaagacact gcgcctgagg     2040

ctgagaagat gccaccggtt tctgccttgt gaaaacaaga gcaaggctgt cgagcagatt     2100

aagaatgctt ttaacaaatt gcaagaaaaa gggatctata aggctatgtc tgagtttgat     2160

atctttatca attatatcga agcttatatg actattaagg cccggtga                  2208


<210>  61
<211>  2288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DK410ngDV06CD14 Variant 2 Nucleic Acid Sequence

<400>  61
atcgaaatta atacgactca ctatagggag acccaagctg gctagcgccg ccaccatggg       60

atggtctttg atcctgctgt tcctggtggc cgtggctacc agagtgcatt ctaccgacca      120

gtgcgacaac ttccctcaga tgctgcggga cctgagagat gccttctcca gagtgaaaac      180

attcttccag accaaggacg aggtggacaa cctgctgctg aaagagtccc tgctggaaga      240

tttcaagggc tacctgggct gtcaggccct gtccgagatg atccagttct acctggaaga      300

agtgatgccc caggccgaga atcaggaccc cgagatcaag gaccacgtga actccctggg      360

cgagaacctg aaaaccctgc ggctgagact gcggcggtgc cacagatttc tgccctgcga      420

gaacaagtcc aaggccgtgg aacagatcaa gaacgccttc aacaagctgc aagagaaggg      480

catctacaag gccatgagcg agttcgacat cttcatcaac tacatcgagg cctacatgac      540

catcaaggcc agaggcggcg gaggatctgg cggaggtgga agcggaggcg gtggatctca      600

ggttcagttg cagcaatggg gcgctggcct gctgaagcct tctgagacac tgtctctgac      660

ctgcgccgtg tacggctact ccatcacctc tgactctgcc tggaattgga tccggcagcc      720

tcctggcaaa ggactggaat ggatcggcta catctcctac tccggctcca ccagctacaa      780

ccccagcctg aagtctagag tggccatctc cgtggacacc tccaagaacc agttctccct      840

gagactgaac tccgtgaccg ccgctgatac cgccatctac tactgcacct ccggcctgag      900

atttgcctac tggggcaagg gcaccaccgt gactgttagt agtggtggtg gcggtagtgg      960

cggaggcggc tcaggcggtg gcggatctca taagtgcgac atcaccctgc aagaaatcat     1020

caagaccctg aacagcctga ccgagcagaa aacactgtgc accgagctga ccgtgaccga     1080

tatctttgcc gcctctaagg ccacaaccga gaaagagaca ttctgcagag ccgccaccgt     1140

gctgcggcag ttttactctc accacgagaa ggacaccaga tgcctgggcg ctaccgctca     1200

gcagttccac agacacaagc agctgatccg gttcctgaag cggctggaca gaaacctgtg     1260

gggactcgcc ggcctgaact cttgccctgt gaaagaggcc aaccagtcta ccctggaaaa     1320

cttcctggaa cggctcaaga ccatcatgcg cgagaagtac tccaagtgct ccagcggtgg     1380

cggtggttca ggtggcggtg gctctggcgg cggaggtagt gaaattgtga tgacccagtc     1440

tcctggcact ctgtctctgt ctcccggcga gagagctacc ctgtcttgta gagcctccga     1500

gtccgtggac tcctacgtga acagcttcct gcactggttc cagcagaagc ctggacaggc     1560

tcccagactg ctgatctaca gagcctccaa cctgcagagc ggcttccctg acagattttc     1620

cggctctggc tccggcaccg acttcaccct gacaatcacc agactggaac ccgaggactt     1680

cgctatgtac tactgccagc agtccaacga ggaccccacc acatttggcc agggcaccaa     1740

gctggaaatc aaaggtggcg gaggaagtgg tggcggaggc tccggcggag gcggttctac     1800

agatcagtgt gataattttc cacagatgct ccgcgatctg cgggacgcct ttagccgggt     1860

caagacattt tttcagacaa aggatgaagt cgataacctc ttgctcaaag agagcctgct     1920

cgaggacttt aagggatatc tgggatgcca ggctctgagc gaaatgattc agttttatct     1980

cgaggaagtc atgcctcaag cagagaacca ggatccagag attaaggatc atgtgaatag     2040

cctcggggag aacctcaaga cactgagact ccggctgaga agatgccacc ggtttctgcc     2100

ttgtgaaaac aaaagcaagg ctgtcgagca gattaagaat gcttttaaca aactccaaga     2160

aaaagggatc tataaggcta tgtctgagtt tgatatcttt atcaattata tcgaagctta     2220

tatgactatt aaggctcgct aggggcccgt ttaaacccgc tgatcagcct cgactgtgcc     2280

ttctagtt                                                              2288


<210>  62
<211>  2303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DK210her2 Variant 4 Nucleic Acid Sequence

<400>  62
atcgaaatta atacgactca ctatagggag acccaagctg gctagcgccg ccaccatggg       60

atggtctttg atcctgctgt tcctggtggc cgtggctacc agagtgcatt ctaccgacca      120

gtgcgacaac ttccctcaga tgctgcggga cctgagagat gccttctcca gagtgaaaac      180

attcttccag accaaggacg agctggacaa cctgctgctg aaagagtccc tgctggaaga      240

tttcaagggc tacctgggct gtcaggccct gtccgagatg atccagttct acctggaaga      300

agtgatgccc caggccgaga atcaggaccc cgagatcaag gaccacgtga actccctggg      360

cgagaacctg aaaaccctgc ggctgagact gcggcggtgc cacagatttc tgccctgcga      420

gaacaagtcc aaggccgtgg aacagatcaa gaacgccttc aacaagctgc aagagaaggg      480

catctacaag gccatgagcg agttcgacat cttcatcaac tacatcgagg cctacatgac      540

catcaaggcc agaggcggcg gaggatctgg cggaggtgga agcggaggcg gtggatctca      600

ggtgcagttg caagaatggg gcgctggcct gctgaagcct tccgaaacac tgtctctgac      660

ctgcgccgcc agcggcttca acatcaagga cacctacatc cactgggtcc gacagcctcc      720

aggcaaagga ctggaatggg tcgccagaat ctaccccacc aacggctaca ccagatacgc      780

cgactctgtg aagggcagat tcgccatctc tgccgacacc tccaagaacc aggccagcct      840

gagactgaac tctgtgaccg ctgctgacac cgccgtgtac tactgctcta gatggggcgg      900

agatggcttc tacgccatgg actattgggg caagggcacc accgtgacag ttagtagtgg      960

tggtggcggt agtggcggag gcggctcagg cggtggtgga tctgctccta catcctccag     1020

caccaagaaa acccagctgc agttggagca tctgctgctg gacctccaga tgatcctgaa     1080

cggcatcaac aactacaaga accccaagct gacccggatg ctgaccttca agttctacat     1140

gcccaagaag gccaccgagc tgaaacatct gcagtgcctg gaagaggaac tgaagcccct     1200

cgaggaagtg ctgaatctgg cccagtccaa gaacttccac ctgaggccta gggacctgat     1260

ctccaacatc aacgtgatcg tgctcgagct gaagggctcc gagacaacct tcatgtgcga     1320

gtacgccgac gagacagcta ccatcgtgga atttctgaac cggtggatca ccttctgcca     1380

gtccatcatc tctaccctga ctggtggcgg aggaagcggc ggaggcggat ctggcggcgg     1440

aggctctgaa attgtgatga cccagtctcc tggcactctg tctctgtctc ccggcgagag     1500

agctaccctg tcttgtagag ccagccagga cgtgaacacc gctgtggctt ggtatcagca     1560

gaagcctgga caggcccctc ggctgctgat ctactctgcc tcctttctgt actccggcgt     1620

gcccgacaga ttctccggct ctagatctgg caccgacttc accctgacca tcaccagact     1680

ggaacccgag gacttcgcca cctactactg ccagcagcac tacaccacac cacctacctt     1740

tggccagggc accaagctgg aaatcaaagg tggtggcgga tcaggcggtg gcggtagcgg     1800

tggcggaggt tctacagacc agtgtgataa ttttccccaa atgctgaggg atctgcggga     1860

cgccttctct agggtcaaga cattttttca gacaaaggat gaactcgata acctcttgct     1920

caaagagagc ctgctcgagg actttaaggg atatctggga tgccaggctc tgagcgaaat     1980

gattcagttt tatttggagg aagtcatgcc tcaagcagaa aaccaggatc cagagattaa     2040

ggatcatgtc aacagcctcg gcgagaatct caagacactg cgcctgaggc tgagaagatg     2100

ccaccggttt ctgccttgtg aaaacaaaag caaggctgtc gagcagatta agaatgcttt     2160

taacaaactc caagaaaaag ggatctataa ggctatgtct gagtttgata tctttatcaa     2220

ttatatcgaa gcttatatga ctattaaggc tcgctagggg cccgtttaaa cccgctgatc     2280

agcctcgact gtgccttcta gtt                                             2303


<210>  63
<211>  2303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DK210her2 Variant 5 Nucleic Acid Sequence

<400>  63
atcgaaatta atacgactca ctatagggag acccaagctg gctagcgccg ccaccatggg       60

atggtctttg atcctgctgt tcctggtggc cgtggctacc agagtgcatt ctaccgacca      120

gtgcgacaac ttccctcaga tgctgcggga cctgagagat gccttctcca gagtgaaaac      180

attcttccag accaaggacg agctggacaa cctgctgctg aaagagtccc tgctggaaga      240

tttcaagggc tacctgggct gtcaggccct gtccgagatg atccagttct acctggaaga      300

agtgatgccc caggccgaga atcaggaccc cgagatcaag gaccacgtga actccctggg      360

cgagaacctg aaaaccctgc ggctgagact gcggcggtgc cacagatttc tgccctgcga      420

gaacaagtcc aaggccgtgg aacagatcaa gaacgccttc aacaagctgc aagagaaggg      480

catctacaag gccatgagcg agttcgacat cttcatcaac tacatcgagg cctacatgac      540

catcaaggcc agaggcggcg gaggatctgg cggaggtgga agcggaggcg gtggatctca      600

ggtgcagttg caagaatggg gcgctggcct gctgaagcct tccgaaacac tgtctctgac      660

ctgcgccgcc agcggcttca acatcaagga cacctacatc cactgggtcc gacagcctcc      720

aggcaaagga ctggaatggg tcgccagaat ctaccccacc aacggctaca ccagatacgc      780

cgactctgtg aagggcagat tcgccatctc tgccgacacc tccaagaacc aggccagcct      840

gcagatgaac agcctgagag ctgaggacac cgccgtgtac tactgctcta gatggggcgg      900

agatggcttc tacgccatgg actattgggg caagggcacc accgtgacag ttagtagtgg      960

tggtggcggt agtggcggag gcggctcagg cggtggtgga tctgctccta catcctccag     1020

caccaagaaa acccagctgc agttggagca tctgctgctg gacctccaga tgatcctgaa     1080

cggcatcaac aactacaaga accccaagct gacccggatg ctgaccttca agttctacat     1140

gcccaagaag gccaccgagc tgaaacatct gcagtgcctg gaagaggaac tgaagcccct     1200

cgaggaagtg ctgaatctgg cccagtccaa gaacttccac ctgaggccta gggacctgat     1260

ctccaacatc aacgtgatcg tgctcgagct gaagggctcc gagacaacct tcatgtgcga     1320

gtacgccgac gagacagcta ccatcgtgga atttctgaac cggtggatca ccttctgcca     1380

gtccatcatc tctaccctga ctggtggcgg aggaagcggc ggaggcggat ctggcggcgg     1440

aggctctgaa attcagatga cccagtctcc ttccagcctg tctctgtccc ctggcgagag     1500

agctaccctg tcttgtagag ccagccagga cgtgaacacc gctgtggctt ggtatcagca     1560

gaagcctgga caggcccctc ggctgctgat ctactctgcc tcctttctgt actccggcgt     1620

gcccgacaga ttctccggct ctagatctgg caccgacttt accctgacaa tcagctccct     1680

gcagcctgag gacttcgcca cctactactg ccagcagcac tacaccacac cacctacctt     1740

tggccagggc accaagctgg aaatcaaagg tggtggcgga tcaggcggtg gcggtagcgg     1800

tggcggaggt tctacagacc agtgtgataa ttttccccaa atgctgaggg atctgcggga     1860

cgccttctct agggtcaaga cattttttca gacaaaggat gaactcgata acctcttgct     1920

caaagagagc ctgctcgagg acttcaaagg atatctggga tgccaggctc tgagcgaaat     1980

gattcagttt tatttggagg aagtcatgcc tcaagcagaa aaccaggatc cagagattaa     2040

ggatcatgtc aacagcctcg gcgagaatct caagacactg agactgaggc tgcggagatg     2100

tcaccggttt ctgccttgtg aaaacaagag caaggctgtc gagcagatta agaatgcttt     2160

taacaaactc caagaaaaag ggatctataa ggctatgtct gagtttgata tctttatcaa     2220

ttatatcgaa gcttatatga ctattaaggc tcgctagggg cccgtttaaa cccgctgatc     2280

agcctcgact gtgccttcta gtt                                             2303
















