                               SEQUENCE LISTING

<110> INSPIRAR LIMITED
 
<120> COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE DISEASES

<130> 57837-708.601

<140>
<141>

<150> CN 202010705069.X
<151> 2020-07-21

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 1152
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Val Ser Glu Gly Lys 
625                 630                 635                 640 


Ala Lys Ser Val Gly Glu Ala Glu Asp Gly Pro Glu Gly Arg Gly Asp 
                645                 650                 655     


Gly Thr Cys Glu Glu Gly Ser Ser Gly Ala Glu His Trp Gln Asp Glu 
            660                 665                 670         


Glu Arg Glu Lys Gly Glu Lys Asp Lys Gly Arg Gly Glu Met Glu Arg 
        675                 680                 685             


Pro Gly Glu Gly Glu Lys Glu Leu Ala Glu Lys Glu Glu Trp Lys Lys 
    690                 695                 700                 


Arg Asp Gly Glu Glu Gln Glu Gln Lys Glu Arg Glu Gln Gly His Gln 
705                 710                 715                 720 


Lys Glu Arg Asn Gln Glu Met Glu Glu Gly Gly Glu Glu Glu His Gly 
                725                 730                 735     


Glu Gly Glu Glu Glu Glu Gly Asp Arg Glu Glu Glu Glu Glu Lys Glu 
            740                 745                 750         


Gly Glu Gly Lys Glu Glu Gly Glu Gly Glu Glu Val Glu Gly Glu Arg 
        755                 760                 765             


Glu Lys Glu Glu Gly Glu Arg Lys Lys Glu Glu Arg Ala Gly Lys Glu 
    770                 775                 780                 


Glu Lys Gly Glu Glu Glu Gly Asp Gln Gly Glu Gly Glu Glu Glu Glu 
785                 790                 795                 800 


Thr Glu Gly Arg Gly Glu Glu Lys Glu Glu Gly Gly Glu Val Glu Gly 
                805                 810                 815     


Gly Glu Val Glu Glu Gly Lys Gly Glu Arg Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu 
        835                 840                 845             


Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu 
    850                 855                 860                 


Gly Glu Gly Glu Glu Glu Gly Glu Glu Gly Glu Gly Glu Gly Glu Glu 
865                 870                 875                 880 


Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu 
                885                 890                 895     


Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly 
            900                 905                 910         


Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu Gly 
        915                 920                 925             


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Asp Gly 
    930                 935                 940                 


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Trp Glu Gly Glu Glu Glu 
945                 950                 955                 960 


Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu 
                965                 970                 975     


Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu 
            980                 985                 990         


Glu Glu Gly Glu Glu Glu Gly Glu  Glu Glu Gly Glu Gly  Glu Glu Glu 
        995                 1000                 1005             


Gly Glu  Gly Glu Gly Glu Glu  Glu Glu Glu Gly Glu  Val Glu Gly 
    1010                 1015                 1020             


Glu Val  Glu Gly Glu Glu Gly  Glu Gly Glu Gly Glu  Glu Glu Glu 
    1025                 1030                 1035             


Gly Glu  Glu Glu Gly Glu Glu  Arg Glu Lys Glu Gly  Glu Gly Glu 
    1040                 1045                 1050             


Glu Asn  Arg Arg Asn Arg Glu  Glu Glu Glu Glu Glu  Glu Gly Lys 
    1055                 1060                 1065             


Tyr Gln  Glu Thr Gly Glu Glu  Glu Asn Glu Arg Gln  Asp Gly Glu 
    1070                 1075                 1080             


Glu Tyr  Lys Lys Val Ser Lys  Ile Lys Gly Ser Val  Lys Tyr Gly 
    1085                 1090                 1095             


Lys His  Lys Thr Tyr Gln Lys  Lys Ser Val Thr Asn  Thr Gln Gly 
    1100                 1105                 1110             


Asn Gly  Lys Glu Gln Arg Ser  Lys Met Pro Val Gln  Ser Lys Arg 
    1115                 1120                 1125             


Leu Leu  Lys Asn Gly Pro Ser  Gly Ser Lys Lys Phe  Trp Asn Asn 
    1130                 1135                 1140             


Val Leu  Pro His Tyr Leu Glu  Leu Lys 
    1145                 1150         


<210> 2
<211> 3459
<212> DNA
<213> Homo sapiens

<400> 2
atgagggagc cggaagagct gatgcccgat tcgggtgctg tgtttacatt tgggaaaagt       60

aaatttgctg aaaataatcc cggtaaattc tggtttaaaa atgatgtccc tgtacatctt      120

tcatgtggag atgaacattc tgctgttgtt accggaaata ataaacttta catgtttggc      180

agtaacaact ggggtcagtt aggattagga tcaaagtcag ccatcagcaa gccaacatgt      240

gtcaaagctc taaaacctga aaaagtgaaa ttagctgcct gtggaaggaa ccacaccctg      300

gtgtcaacag aaggaggcaa tgtatatgca actggtggaa ataatgaagg acagttgggg      360

cttggtgaca ccgaagaaag aaacactttt catgtaatta gcttttttac atccgagcat      420

aagattaagc agctgtctgc tggatctaat acttcagctg ccctaactga ggatggaaga      480

ctttttatgt ggggtgacaa ttccgaaggg caaattggtt taaaaaatgt aagtaatgtc      540

tgtgtccctc agcaagtgac cattgggaaa cctgtctcct ggatctcttg tggatattac      600

cattcagctt ttgtaacaac agatggtgag ctatatgtgt ttggagaacc tgagaatggg      660

aagttaggtc ttcccaatca gctcctgggc aatcacagaa caccccagct ggtgtctgaa      720

attccggaga aggtgatcca agtagcctgt ggtggagagc atactgtggt tctcacggag      780

aatgctgtgt atacctttgg gctgggacaa tttggtcagc tgggtcttgg cacttttctt      840

tttgaaactt cagaacccaa agtcattgag aatattaggg atcaaacaat aagttatatt      900

tcttgtggag aaaatcacac agctttgata acagatatcg gccttatgta tacttttgga      960

gatggtcgcc acggaaaatt aggacttgga ctggagaatt ttaccaatca cttcattcct     1020

actttgtgct ctaatttttt gaggtttata gttaaattgg ttgcttgtgg tggatgtcac     1080

atggtagttt ttgctgctcc tcatcgtggt gtggcaaaag aaattgaatt cgatgaaata     1140

aatgatactt gcttatctgt ggcgactttt ctgccgtata gcagtttaac ctcaggaaat     1200

gtactgcaga ggactctatc agcacgtatg cggcgaagag agagggagag gtctccagat     1260

tctttttcaa tgaggagaac actacctcca atagaaggga ctcttggcct ttctgcttgt     1320

tttctcccca attcagtctt tccacgatgt tctgagagaa acctccaaga gagtgtctta     1380

tctgaacagg acctcatgca gccagaggaa ccagattatt tgctagatga aatgaccaaa     1440

gaagcagaga tagataattc ttcaactgta gaaagccttg gagaaactac tgatatctta     1500

aacatgacac acatcatgag cctgaattcc aatgaaaagt cattaaaatt atcaccagtt     1560

cagaaacaaa agaaacaaca aacaattggg gaactgacgc aggatacagc tcttactgaa     1620

aacgatgata gtgatgaata tgaagaaatg tcagaaatga aagaagggaa agcatgtaaa     1680

caacatgtgt cacaagggat tttcatgacg cagccagcta cgactatcga agcattttca     1740

gatgaggaag tagagatccc agaggagaag gaaggagcag aggattcaaa aggaaatgga     1800

atagaggagc aagaggtaga agcaaatgag gaaaatgtga aggtgcatgg aggaagaaag     1860

gagaaaacag agatcctatc agatgacctt acagacaaag cagaggtgag tgaaggcaag     1920

gcaaaatcag tgggagaagc agaggatggg cctgaaggta gaggggatgg aacctgtgag     1980

gaaggtagtt caggagcaga acactggcaa gatgaggaga gggagaaggg ggagaaagac     2040

aagggtagag gagaaatgga gaggccagga gagggagaga aggaactagc agagaaggaa     2100

gaatggaaga agagggatgg ggaagagcag gagcaaaagg agagggagca gggccatcag     2160

aaggaaagaa accaagagat ggaggaggga ggggaggagg agcatggaga aggagaagaa     2220

gaggagggag acagagaaga ggaagaagag aaggagggag aagggaaaga ggaaggagaa     2280

ggggaagaag tggagggaga acgtgaaaag gaggaaggag agaggaaaaa ggaggaaaga     2340

gcggggaagg aggagaaagg agaggaagaa ggagaccaag gagaggggga agaggaggaa     2400

acagagggga gaggggagga aaaagaggag ggaggggaag tagagggagg ggaagtagag     2460

gaggggaaag gagagaggga agaggaagag gaggagggtg agggggaaga ggaggaaggg     2520

gagggggaag aggaggaagg ggagggggaa gaggaggaag gagaagggaa aggggaggaa     2580

gaaggggaag aaggagaagg ggaggaagaa ggggaggaag gagaagggga gggggaagag     2640

gaggaaggag aaggggaggg agaagaggaa ggagaagggg agggagaaga ggaggaagga     2700

gaaggggagg gagaagagga aggagaaggg gagggagaag aggaggaagg agaagggaaa     2760

ggggaggagg aaggagagga aggagaaggg gagggggaag aggaggaagg agaaggggaa     2820

ggggaggatg gagaagggga gggggaagag gaggaaggag aatgggaggg ggaagaggag     2880

gaaggagaag gggaggggga agaggaagga gaaggggaag gggaggaagg agaaggggag     2940

ggggaagagg aggaaggaga aggggagggg gaagaggagg aaggggaaga agaaggggag     3000

gaagaaggag agggagagga agaaggggag ggagaagggg aggaagaaga ggaaggggaa     3060

gtggaagggg aggtggaagg ggaggaagga gagggggaag gagaggaaga ggaaggagag     3120

gaggaaggag aagaaaggga aaaggagggg gaaggagaag aaaacaggag gaacagagaa     3180

gaggaggagg aagaagaggg gaagtatcag gagacaggcg aagaagagaa tgaaaggcag     3240

gatggagagg agtacaaaaa agtgagcaaa ataaaaggat ctgtgaaata tggcaaacat     3300

aaaacatatc aaaaaaagtc agttactaac acacagggaa atgggaaaga gcagaggtcc     3360

aaaatgccag tccagtcaaa acgactttta aaaaacgggc catcaggttc caaaaagttc     3420

tggaataatg tattaccaca ttacttggaa ttgaagtaa                            3459


<210> 3
<211> 3459
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgagagagc cagaggagct gatgccagac agtggagcag tgtttacatt cggaaaatct       60

aagttcgctg aaaataaccc aggaaagttc tggtttaaaa acgacgtgcc cgtccacctg      120

tcttgtggcg atgagcatag tgccgtggtc actgggaaca ataagctgta catgttcggg      180

tccaacaact ggggacagct ggggctggga tccaaatctg ctatctctaa gccaacctgc      240

gtgaaggcac tgaaacccga gaaggtcaaa ctggccgctt gtggcagaaa ccacactctg      300

gtgagcaccg agggcgggaa tgtctatgcc accggaggca acaatgaggg acagctggga      360

ctgggggaca ctgaggaaag gaataccttt cacgtgatct ccttctttac atctgagcat      420

aagatcaagc agctgagcgc tggctccaac acatctgcag ccctgactga ggacgggcgc      480

ctgttcatgt ggggagataa ttcagagggc cagattgggc tgaaaaacgt gagcaatgtg      540

tgcgtccctc agcaggtgac catcggaaag ccagtcagtt ggatttcatg tggctactat      600

catagcgcct tcgtgaccac agatggcgag ctgtacgtct ttggggagcc cgaaaacgga      660

aaactgggcc tgcctaacca gctgctgggc aatcaccgga caccccagct ggtgtccgag      720

atccctgaaa aagtgatcca ggtcgcctgc gggggagagc atacagtggt cctgactgag      780

aatgctgtgt ataccttcgg actgggccag tttggccagc tggggctggg aaccttcctg      840

tttgagacat ccgaaccaaa agtgatcgag aacattcgcg accagactat cagctacatt      900

tcctgcggag agaatcacac cgcactgatc acagacattg gcctgatgta tacctttggc      960

gatggacgac acgggaagct gggactggga ctggagaact tcactaatca ttttatcccc     1020

accctgtgtt ctaacttcct gcggttcatc gtgaaactgg tcgcttgcgg cgggtgtcac     1080

atggtggtct tcgctgcacc tcataggggc gtggctaagg agatcgaatt tgacgagatt     1140

aacgatacat gcctgagcgt ggcaactttc ctgccataca gctccctgac ttctggcaat     1200

gtgctgcaga gaaccctgag tgcaaggatg cggagaaggg agagggaacg ctctcctgac     1260

agtttctcaa tgcgacgaac cctgccacct atcgagggaa cactgggact gagtgcctgc     1320

ttcctgccta actcagtgtt tccacgatgt agcgagcgga atctgcagga gtctgtcctg     1380

agtgagcagg atctgatgca gccagaggaa cccgactacc tgctggatga gatgaccaag     1440

gaggccgaaa tcgacaactc tagtacagtg gagtccctgg gcgagactac cgatatcctg     1500

aatatgacac acattatgtc actgaacagc aatgagaaga gtctgaaact gtcaccagtg     1560

cagaagcaga agaaacagca gactattggc gagctgactc aggacaccgc cctgacagag     1620

aacgacgata gcgatgagta tgaggaaatg tccgagatga aggaaggcaa agcttgtaag     1680

cagcatgtca gtcaggggat cttcatgaca cagccagcca caactattga ggctttttca     1740

gacgaggaag tggagatccc cgaggaaaaa gagggcgcag aagattccaa ggggaatgga     1800

attgaggaac aggaggtgga agccaacgag gaaaatgtga aagtccacgg aggcaggaag     1860

gagaaaacag aaatcctgtc tgacgatctg actgacaagg ccgaggtgtc cgaaggcaag     1920

gcaaaatctg tcggagaggc agaagacgga ccagagggac gaggggatgg aacctgcgag     1980

gaaggctcaa gcggggctga gcattggcag gacgaggaac gagagaaggg cgaaaaggat     2040

aaaggccgcg gggagatgga acgacctgga gagggcgaaa aagagctggc agagaaggag     2100

gaatggaaga aaagggacgg cgaggaacag gagcagaaag aaagggagca gggccaccag     2160

aaggagcgca accaggagat ggaagagggc ggcgaggaag agcatggcga gggagaagag     2220

gaagagggcg atagagaaga ggaagaggaa aaagaaggcg aagggaagga ggaaggagag     2280

ggcgaggaag tggaaggcga gagggaaaag gaggaaggag aacggaagaa agaggaaaga     2340

gccggcaaag aggaaaaggg cgaggaagag ggcgatcagg gcgaaggcga ggaggaagag     2400

accgagggcc gcggggaaga gaaagaggag ggaggagagg tggagggcgg agaggtcgaa     2460

gagggaaagg gcgagcgcga agaggaagag gaagagggcg agggcgagga agaagagggc     2520

gagggggaag aagaggaggg agagggcgaa gaggaagagg gggagggaaa gggcgaagag     2580

gaaggagagg aaggggaggg agaggaagag ggggaggagg gcgaggggga aggcgaggag     2640

gaagaaggag agggggaagg cgaagaggaa ggcgaggggg aaggagagga ggaagaaggg     2700

gaaggcgaag gcgaagagga gggagaagga gagggggagg aagaggaagg agaagggaag     2760

ggcgaggagg aaggcgaaga gggagagggg gaaggcgagg aagaggaagg cgagggcgaa     2820

ggagaggacg gcgagggcga gggagaagag gaggaagggg aatgggaagg cgaagaagag     2880

gaaggcgaag gcgaaggcga agaagagggc gaaggggagg gcgaggaggg cgaaggcgaa     2940

ggggaggaag aggaaggcga aggagaaggc gaggaagaag agggagagga ggaaggcgag     3000

gaggaaggag agggggagga ggagggagaa ggcgagggcg aagaagaaga agagggagaa     3060

gtggagggcg aagtcgaggg ggaggaggga gaaggggaag gggaggaaga agagggcgaa     3120

gaagaaggcg aggaaagaga aaaagaggga gaaggcgagg aaaaccggag aaatagggaa     3180

gaggaggaag aggaagaggg aaagtaccag gagacaggcg aagaggaaaa cgagcggcag     3240

gatggcgagg aatataagaa agtgagcaag atcaaaggat ccgtcaagta cggcaagcac     3300

aaaacctatc agaagaaaag cgtgaccaac acacagggga atggaaaaga gcagaggagt     3360

aagatgcctg tgcagtcaaa acggctgctg aagaatggcc catctggaag taaaaaattc     3420

tggaacaatg tgctgcccca ctatctggaa ctgaaataa                            3459


<210> 4
<211> 3459
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgagagagc cagaggagct gatgccagat agcggagcag tgtttacctt cggaaagtcc       60

aagttcgcag agaataaccc aggaaagttc tggtttaaaa acgacgtgcc cgtccacctg      120

tcttgtggcg atgagcatag tgccgtggtc actgggaaca ataagctgta tatgttcggg      180

tccaacaatt ggggacagct ggggctggga tccaaatctg ctatctctaa gccaacctgc      240

gtgaaggcac tgaaacccga gaaggtcaaa ctggccgctt gtggcagaaa ccacactctg      300

gtgagcaccg agggcgggaa tgtctatgcc accggaggca acaatgaggg acagctggga      360

ctgggggaca ctgaggaaag gaataccttt cacgtgatct ccttctttac atctgagcat      420

aagatcaagc agctgagcgc cggctccaac acatctgcag ccctgactga ggacgggcgc      480

ctgttcatgt ggggagataa ttcagagggc cagattgggc tgaaaaacgt gagcaacgtg      540

tgcgtgcctc agcaggtgac catcggaaag ccagtcagtt ggatttcatg tggctactat      600

catagcgcct tcgtgaccac agatggcgag ctgtacgtct ttggggagcc cgaaaacgga      660

aaactgggcc tgcctaacca gctgctgggc aatcaccgga caccccagct ggtgtccgag      720

atccctgaaa aagtgatcca ggtcgcctgc gggggagagc atacagtggt cctgactgag      780

aatgccgtgt acaccttcgg actgggccag tttggccagc tggggctggg aaccttcctg      840

tttgagacat ccgaaccaaa agtgatcgag aacattcgcg accagactat cagctacatt      900

tcctgcggag agaatcacac cgcactgatc acagacattg gcctgatgta tacctttggc      960

gatgggcggc acgggaagct gggactgggc ctggagaact tcactaatca cttcatcccc     1020

accctgtgct ctaacttcct gcggttcatc gtgaaactgg tcgcttgcgg cgggtgtcac     1080

atggtggtct tcgctgcacc tcataggggc gtggctaagg agatcgaatt tgacgagatt     1140

aacgatacat gcctgagcgt ggcaactttc ctgccataca gctccctgac ttctggcaat     1200

gtgctgcaga gaaccctgag tgcaaggatg cggagaaggg agagggaacg ctctcctgac     1260

agtttctcaa tgcgacgaac cctgccacct atcgagggga cactgggact gagtgcctgc     1320

ttcctgccta actcagtgtt tccacgatgt agcgagcgga atctgcagga gtctgtcctg     1380

agtgagcagg atctgatgca gccagaggaa cccgactacc tgctggatga gatgaccaag     1440

gaggccgaaa tcgacaactc tagtacagtg gagtccctgg gcgagactac cgatatcctg     1500

aatatgacac acattatgtc actgaacagc aatgagaaga gtctgaaact gtcaccagtg     1560

cagaagcaga agaaacagca gactattggc gagctgactc aggacaccgc cctgacagag     1620

aacgacgata gcgatgagta tgaggaaatg tccgagatga aggaaggcaa agcttgtaag     1680

cagcatgtga gtcaggggat cttcatgaca cagccagcca caactattga ggctttttca     1740

gacgaggaag tggagatccc cgaggaaaaa gagggcgcag aagattccaa ggggaatgga     1800

attgaggaac aggaggtgga agccaacgag gaaaatgtga aagtccacgg aggcaggaag     1860

gagaaaacag aaatcctgtc tgacgatctg actgacaagg ccgaggtgtc cgaaggcaag     1920

gcaaaatctg tcggagaggc agaagacgga ccagagggac gaggggatgg aacctgcgag     1980

gaaggctcaa gcggggctga gcattggcag gacgaggaac gagagaaggg cgaaaaggat     2040

aaaggccgcg gggagatgga acgacctgga gagggcgaaa aagagctggc agagaaggag     2100

gaatggaaga aaagggacgg cgaggaacag gagcagaaag aaagggagca gggccaccag     2160

aaggagcgca accaggagat ggaagagggc ggcgaggaag agcatggcga gggagaagag     2220

gaagagggcg atagagaaga ggaagaggaa aaagaaggcg aagggaagga ggaaggagag     2280

ggcgaggaag tggaaggcga gagggaaaag gaggaaggag aacggaagaa agaggaaaga     2340

gccggcaaag aggaaaaggg cgaggaagag ggcgatcagg gcgaaggcga ggaggaagag     2400

accgagggcc gcggggaaga gaaagaggag ggaggagagg tggagggcgg agaggtcgaa     2460

gagggaaagg gcgagcgcga agaggaagag gaagagggcg agggcgagga agaagagggc     2520

gagggggaag aagaggaggg agagggcgaa gaggaagagg gggagggaaa gggcgaagag     2580

gaaggagagg aaggggaggg agaggaagag ggggaggagg gcgaggggga aggcgaggag     2640

gaagaaggag agggggaagg cgaagaggaa ggcgaggggg aaggagagga ggaagaaggg     2700

gaaggcgaag gcgaagagga gggagaagga gagggggagg aagaggaagg agaagggaag     2760

ggcgaggagg aaggcgaaga gggagagggg gaaggcgagg aagaggaagg cgagggcgaa     2820

ggagaggacg gcgagggcga gggagaagag gaggaagggg aatgggaagg cgaagaagag     2880

gaaggcgaag gcgaaggcga agaagagggc gaaggggagg gcgaggaggg cgaaggcgaa     2940

ggggaggaag aggaaggcga aggagaaggc gaggaagaag agggagagga ggaaggcgag     3000

gaggaaggag agggggagga ggagggagaa ggcgagggcg aagaagaaga agagggagaa     3060

gtggagggcg aagtcgaggg ggaggaggga gaaggggaag gggaggaaga agagggcgaa     3120

gaagaaggcg aggaaagaga aaaagaggga gaaggcgagg aaaaccggag aaatagggaa     3180

gaggaggaag aggaagaggg aaagtaccag gagacaggcg aagaggaaaa cgagcggcag     3240

gatggcgagg aatataagaa agtgagcaag atcaaaggat ccgtcaagta cggcaagcac     3300

aaaacctatc agaagaaaag cgtgaccaac acacagggga atggaaaaga gcagcgaagt     3360

aaaatgcctg tgcagtcaaa acggctgctg aagaatggcc caagcgggtc taaaaaattc     3420

tggaacaatg tcctgccaca ctatctggaa ctgaagtga                            3459


<210> 5
<211> 3459
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atgagagagc ccgaggaact gatgcccgat agcggagccg tcttcacctt tgggaaatct       60

aaattcgcag agaacaaccc tggaaaattc tggtttaaga acgacgtgcc cgtgcacctg      120

agctgtggcg atgagcactc cgccgtggtg acaggcaaca ataagctgta catgttcggc      180

tctaacaatt ggggacagct gggcctggga agcaagtccg ccatcagcaa gccaacctgc      240

gtgaaggccc tgaagcccga gaaggtgaag ctggccgcct gtggcagaaa ccacacactg      300

gtgagcaccg agggcggcaa tgtgtatgcc acaggcggca acaatgaagg acagctgggc      360

ctgggcgaca cagaggagag gaataccttt cacgtgatca gcttctttac ctccgagcac      420

aagatcaagc agctgtccgc cggctctaac acatctgcag cactgacaga ggatggaaga      480

ctgttcatgt ggggcgataa tagcgagggc cagatcggcc tgaagaacgt gtccaatgtg      540

tgcgtgcctc agcaggtgac catcggcaag ccagtgtcct ggatctcttg tggctactat      600

cacagcgcct tcgtgaccac agatggcgag ctgtacgtgt ttggagagcc tgagaatggc      660

aagctgggcc tgcctaacca gctgctgggc aatcaccgga caccccagct ggtgtccgag      720

atccctgaga aagtgatcca ggtggcatgt ggcggcgagc acacagtggt gctgaccgag      780

aatgccgtgt atacctttgg cctgggacag tttggccagc tgggcctggg cacattcctg      840

tttgagacat ccgagccaaa agtgatcgag aacatccgcg accagacaat cagctacatc      900

tcctgcggcg agaatcacac agccctgatc accgacatcg gcctgatgta tacctttggc      960

gatggaagac acggcaagct gggcctgggc ctggagaact tcacaaatca ctttatcccc     1020

accctgtgtt ctaacttcct gcggttcatc gtgaagctgg tggcctgcgg cggatgtcac     1080

atggtggtgt ttgcagcccc tcacaggggc gtggccaagg agatcgagtt tgacgagatc     1140

aacgatacat gcctgtccgt ggccaccttc ctgccataca gctccctgac atccggcaat     1200

gtgctgcaga gaaccctgtc tgcaagaatg agaagaaggg agagagagcg gtcccctgac     1260

tctttcagca tgagaagaac actgccccct attgagggaa ccctgggcct gtctgcctgc     1320

ttcctgccta actctgtgtt tccaagatgt agcgagagga atctgcagga gtctgtgctg     1380

agcgagcagg atctgatgca gccagaggag cccgactacc tgctggatga gatgacaaag     1440

gaggccgaga tcgacaactc tagcaccgtg gagagcctgg gcgagacaac agatatcctg     1500

aatatgacac acatcatgtc cctgaactct aatgagaagt ctctgaagct gagcccagtg     1560

cagaagcaga agaagcagca gaccatcggc gagctgaccc aggacacagc cctgaccgag     1620

aacgacgatt ctgatgagta tgaggagatg agcgagatga aggagggcaa ggcctgtaag     1680

cagcacgtgt cccagggcat cttcatgacc cagccagcca ccacaatcga ggccttttct     1740

gacgaggagg tggagatccc cgaggagaag gagggcgccg aggatagcaa gggcaatggc     1800

atcgaggagc aggaggtgga ggccaacgag gagaatgtga aggtgcacgg cggaagaaag     1860

gagaagacag agatcctgtc cgacgatctg accgacaagg ccgaggtgtc cgagggcaag     1920

gccaagtctg tgggagaggc agaggatgga cctgagggac gcggcgatgg aacatgtgag     1980

gagggctcct ctggagcaga gcactggcag gatgaggaga gagagaaggg cgagaaggat     2040

aagggcagag gcgagatgga gaggcctgga gagggagaga aggagctggc agagaaggag     2100

gagtggaaga agagggatgg cgaggagcag gagcagaagg agagagagca gggccaccag     2160

aaagagagga accaggagat ggaagagggc ggcgaggagg agcacggaga gggagaggag     2220

gaggagggcg atagagaaga agaggaggag aaagagggag agggcaagga ggagggagag     2280

ggagaagaag tggaaggaga gagagagaag gaggaaggag agcgcaagaa ggaagaaaga     2340

gcaggcaagg aggagaaagg agaggaggag ggcgatcagg gagaaggaga ggaggaggag     2400

acagaaggac gcggcgagga aaaagaggag ggcggcgagg tcgagggcgg cgaggtcgaa     2460

gagggcaagg gcgaaagaga agaagaggag gaggaaggcg agggcgaaga agaggagggc     2520

gagggcgagg aagaagaggg cgagggcgaa gaggaagaag gagagggcaa gggcgaggag     2580

gagggcgaag aaggcgaagg ggaggaggag ggcgaagagg gagagggcga gggcgaggag     2640

gaagaaggcg aaggagaagg cgaagaagaa ggagaaggag agggagaaga ggaggaaggc     2700

gaaggagagg gggaagagga aggagaaggg gagggcgaag aggaggaggg agaaggcaag     2760

ggagaggagg agggcgagga aggagaaggc gaaggcgagg aggaggaagg agagggagaa     2820

ggagaagatg gagaaggaga gggcgaggaa gaggaaggag agtgggaggg cgaggaagag     2880

gagggagaag gagaaggaga agaagaagga gaaggcgagg gagaagaagg agagggagaa     2940

ggggaagaag aggaggggga aggagagggc gaggaggaag agggagaaga agaaggcgaa     3000

gaagagggag aaggcgagga agaaggagag ggagaggggg aagaggagga agagggcgag     3060

gtggaaggag aggtggaggg cgaagagggg gaaggggaag gagaagaaga agaaggagag     3120

gaggagggag aggagagaga gaaagaaggc gagggcgagg agaacagaag gaatcgcgaa     3180

gaagaagaag aagaggaggg caagtaccag gagacaggcg aggaggagaa cgagcggcag     3240

gatggcgagg agtataagaa ggtgtccaag atcaagggct ctgtgaagta cggcaagcac     3300

aagacctatc agaagaagag cgtgaccaac acacagggca atggcaagga gcagcgcagc     3360

aagatgcctg tgcagtccaa gcggctgctg aagaatggcc caagcgggtc taaaaaattc     3420

tggaacaatg tcctgccaca ctatctggaa ctgaaataa                            3459


<210> 6
<211> 3459
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atgagagaac ccgaggaact gatgcctgac tctggcgccg tgttcacctt cggcaagagc       60

aagttcgccg agaacaaccc cggcaagttc tggttcaaga acgacgtgcc agtgcacctg      120

agctgtggcg acgaacattc tgccgtggtc accggcaaca acaagctgta catgttcggc      180

agcaacaact ggggccagct cggcctggga tctaagagcg ccatcagcaa gcctacctgc      240

gtgaaggccc tgaagcctga gaaagtgaag ctggccgcct gcggcagaaa tcacaccctg      300

gtttctaccg aaggcggcaa cgtgtacgcc accggcggaa acaatgaagg acagcttgga      360

ctgggcgaca ccgaggaaag aaacaccttc cacgtgatca gctttttcac cagcgagcac      420

aagatcaagc agctgagcgc cggcagcaat acctctgctg ccctgacaga agatggccgg      480

ctgttcatgt ggggcgacaa ttctgagggc cagatcggac tgaagaacgt gtccaatgtg      540

tgcgtgcccc agcaagtgac aatcggcaag cctgtgtcct ggatcagctg cggctactac      600

cacagcgcct tcgtgacaac agacggcgag ctgtatgtgt tcggcgagcc cgagaatggc      660

aagctgggac tgcctaatca gctgctgggc aaccacagaa cccctcagct ggtgtctgag      720

atccccgaaa aagtgatcca ggtggcctgt ggcggagagc acacagtggt gctgacagag      780

aatgccgtgt acacatttgg cctgggccag tttggccaac tcggactggg caccttcctg      840

ttcgagacaa gcgagcccaa agtgatcgag aacatccggg accagaccat cagctacatc      900

tcttgcggcg agaaccacac agccctgatc acagacatcg gcctgatgta taccttcggc      960

gacggcagac acggcaaact cggccttggc ctggaaaact tcaccaacca cttcatccct     1020

actctgtgca gcaacttcct gcggttcatc gtgaaactgg tggcctgcgg aggctgccac     1080

atggtggttt ttgccgctcc tcatagaggc gtggccaaag agattgagtt cgacgagatc     1140

aacgatacct gcctgagcgt ggccaccttt ctgccttaca gctctctgac cagcggcaat     1200

gtgctgcaga ggacactgag cgccagaatg cgcagacggg aaagagagag aagccccgac     1260

agcttcagca tgcggagaac cctgcctcca atcgagggaa cactgggcct gagcgcctgc     1320

ttcctgccta atagcgtgtt ccccagatgc agcgagcgga acctgcaaga gtctgtgctg     1380

agcgagcagg acctgatgca gcctgaggaa cccgactacc tgctggacga gatgaccaaa     1440

gaggccgaga tcgacaacag cagcaccgtg gaatctctgg gcgagacaac cgacatcctg     1500

aacatgaccc acatcatgag cctgaacagc aacgagaagt ctctgaagct gagccccgtg     1560

cagaagcaga agaagcagca gaccatcgga gagctgaccc aggataccgc tctgaccgag     1620

aacgacgaca gcgacgagta cgaagagatg agcgagatga aggaaggcaa ggcctgcaag     1680

cagcacgtgt cccagggcat ctttatgacc cagcctgcca ccaccatcga ggccttttcc     1740

gacgaggaag tggaaatccc cgaggaaaaa gagggcgccg aggacagcaa aggcaacggc     1800

attgaggaac aagaggtgga agccaacgaa gagaacgtga aggtgcacgg cggacggaaa     1860

gagaaaacag agatcctgag cgacgacctg accgacaagg ccgaagtgtc tgagggcaaa     1920

gccaagtctg tgggcgaagc cgaggacggc ccagaaggca gaggcgacgg aacatgtgaa     1980

gagggatcta gcggagccga gcactggcag gacgaagaga gagagaaagg cgagaaggac     2040

aaaggcaggg gcgagatgga aagacctggc gagggcgaaa aagagctggc cgagaaagag     2100

gagtggaaga aacgcgacgg cgaagaacaa gagcagaaag aacgcgagca gggccaccag     2160

aaagaaagaa atcaagagat ggaagaaggc ggcgaggaag aacacggcga aggggaagaa     2220

gaggaaggcg accgagagga agaagaagaa aaagaaggcg aaggcaaaga ggaaggcgag     2280

ggcgaagagg tggaaggcga gcgggaaaaa gaagagggcg agcgcaagaa agaagaaaga     2340

gccggcaaag aagagaaggg cgaagaagaa ggcgatcaag gcgaaggcga ggaagaagaa     2400

accgaaggcc gcggagaaga gaaagaggaa ggcggcgaag ttgaaggcgg cgaggtggaa     2460

gaaggcaagg gcgagagaga agaagaggaa gaggaaggcg aaggggaaga agaagaaggc     2520

gagggcgaag aggaagaagg cgaaggcgag gaagaggaag gcgaaggcaa gggcgaagag     2580

gaaggcgaag aaggcgaggg cgaagaagag ggagaagaag gcgaaggcga gggcgaagaa     2640

gaggaaggcg aaggcgaagg cgaggaagaa ggcgaaggcg aaggcgaaga ggaagaaggc     2700

gaaggcgaag gggaagaaga aggcgaaggc gaaggcgagg aagaggaagg cgaaggcaaa     2760

ggggaagaag agggcgaaga aggcgaaggc gaaggcgagg aagaagaagg cgaaggcgaa     2820

ggcgaagacg gcgaaggcga gggcgaagag gaagagggcg agtgggaggg cgaagaagaa     2880

gaaggcgaag gcgagggcga agaggaaggc gaaggcgaag gcgaagaagg cgagggcgaa     2940

ggcgaagaag aagaaggcga aggcgaaggc gaagaagagg aaggggaaga agaaggcgaa     3000

gaggaaggcg agggcgaaga agaaggcgaa ggcgagggcg aagaagagga agagggcgaa     3060

gttgaagggg aagttgaggg cgaagaaggc gaaggcgaag gggaagaaga ggaaggcgag     3120

gaagagggcg aagaacgcga gaaagaaggc gaaggggaag agaaccgccg gaacagagaa     3180

gaggaagaag aagaggaagg caagtaccaa gagacaggcg aggaagagaa cgagcggcag     3240

gatggcgaag agtacaagaa ggtgtccaag atcaagggca gcgtgaagta cggcaagcac     3300

aagacctacc agaaaaagtc cgtgaccaac acacaaggca atggcaaaga acagcggagc     3360

aagatgcccg tgcagtccaa gagactgctg aagaatggcc ccagcggcag caaaaagttc     3420

tggaacaacg tgctgcccca ctacctggaa ctgaagtga                            3459


<210> 7
<211> 295
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      GRK1 long (GRK1L) sequence

<400> 7
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttagcctg      180

gtgctgtgtc agccccgggc tcccaggggc ttcccagtgg tccccaggga accctcgaca      240

gggccagggc gtctctctcg tccagcaagg gcagggacgg gccacaggca agggc           295


<210> 8
<211> 199
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      GRK1S short (GRK1S) sequence

<400> 8
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttagcctg      180

gtgctgtgtc agccccggg                                                   199


<210> 9
<211> 225
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      bGHpA sequence

<400> 9
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210> 10
<211> 135
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      SV40pA sequence

<400> 10
gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagtt                                                       135


<210> 11
<211> 56
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      rbGlobpA sequence

<400> 11
aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca           56


<210> 12
<211> 477
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      hGHpA sequence

<400> 12
gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca       60

gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc      120

ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca      180

acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg      240

ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg      300

ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg      360

ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct      420

tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtcctt         477


<210> 13
<211> 97
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      SV40 intron sequence

<400> 13
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


