                               SEQUENCE LISTING

<110> INSPIRAR LIMITED
 
<120> COMPOSITION AND METHOD FOR TREATING EYE DISEASES

<130> 57837-712.601

<140>
<141>

<150> CN 202010706658.X
<151> 2020-07-21

<150> CN 202010706505.5
<151> 2020-07-21

<160> 20    

<170> PatentIn version 3.5

<210> 1
<211> 431
<212> PRT
<213> Homo sapiens

<400> 1
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430     


<210> 2
<211> 210
<212> PRT
<213> Homo sapiens

<400> 2
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Asp Pro Ile Glu 
        195                 200                 205             


Gly Arg 
    210 


<210> 3
<211> 103
<212> PRT
<213> Homo sapiens

<400> 3
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp 
            100             


<210> 4
<211> 107
<212> PRT
<213> Homo sapiens

<400> 4
Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu Lys 
1               5                   10                  15      


Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile Asp 
            20                  25                  30          


Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu Val 
        35                  40                  45              


Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe Leu 
    50                  55                  60                  


Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr 
65                  70                  75                  80  


Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr Phe 
                85                  90                  95      


Val Arg Val His Glu Asp Pro Ile Glu Gly Arg 
            100                 105         


<210> 5
<211> 10
<212> PRT
<213> Homo sapiens

<400> 5
Gly Tyr Asp Phe Thr His Tyr Gly Met Asn 
1               5                   10  


<210> 6
<211> 17
<212> PRT
<213> Homo sapiens

<400> 6
Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe Lys 
1               5                   10                  15      


Arg 
    


<210> 7
<211> 14
<212> PRT
<213> Homo sapiens

<400> 7
Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
1               5                   10                  


<210> 8
<211> 11
<212> PRT
<213> Homo sapiens

<400> 8
Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210> 9
<211> 7
<212> PRT
<213> Homo sapiens

<400> 9
Phe Thr Ser Ser Leu His Ser 
1               5           


<210> 10
<211> 9
<212> PRT
<213> Homo sapiens

<400> 10
Gln Gln Tyr Ser Thr Val Pro Trp Thr 
1               5                   


<210> 11
<211> 231
<212> PRT
<213> Homo sapiens

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu 
225                 230     


<210> 12
<211> 214
<212> PRT
<213> Homo sapiens

<400> 12
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 13
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 13
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttccggaag tgataccggt agacctttcg tagagatgta cagtgaaatc      120

cccgaaatta tacacatgac tgaaggaagg gagctcgtca ttccctgccg ggttacgtca      180

cctaacatca ctgttacttt aaaaaagttt ccacttgaca ctttgatccc tgatggaaaa      240

cgcataatct gggacagtag aaagggcttc atcatatcaa atgcaacgta caaagaaata      300

gggcttctga cctgtgaagc aacagtcaat gggcatttgt ataagacaaa ctatctcaca      360

catcgacaaa ccaatacaat catagatgtg gttctgagtc cgtctcatgg aattgaacta      420

tctgttggag aaaagcttgt cttaaattgt acagcaagaa ctgaactaaa tgtggggatt      480

gacttcaact gggaataccc ttcttcgaag catcagcata agaaacttgt aaaccgagac      540

ctaaaaaccc agtctgggag tgagatgaag aaatttttga gcaccttaac tatagatggt      600

gtaacccgga gtgaccaagg attgtacacc tgtgcagcat ccagtgggct gatgaccaag      660

aagaacagca catttgtcag ggtccatgaa aaggacaaaa ctcacacatg cccaccgtgc      720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1080

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga        1377


<210> 14
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 14
atggtttctt actgggatac cggcgtgctg ctgtgtgccc tgctgtcttg tctgctgctg       60

accggctcta gcagcggctc tgataccggc agacccttcg tggaaatgta cagcgagatc      120

cccgagatca tccacatgac cgagggcaga gagctggtca tcccctgcag agtgacaagc      180

cccaacatca ccgtgactct gaagaagttc cctctggaca cactgatccc cgacggcaag      240

agaatcatct gggacagccg gaagggcttc atcatcagca acgccaccta caaagagatc      300

ggcctgctga cctgtgaagc caccgtgaat ggccacctgt acaagaccaa ctacctgaca      360

cacagacaga ccaacaccat catcgacgtg gtgctgagcc ctagccacgg cattgaactg      420

tctgtgggcg agaagctggt gctgaactgt accgccagaa ccgagctgaa cgtgggcatc      480

gacttcaact gggagtaccc cagcagcaag caccagcaca agaaactggt caaccgggac      540

ctgaaaaccc agagcggcag cgagatgaag aaattcctga gcaccctgac catcgacggc      600

gtgaccaggt ctgaccaggg cctgtacaca tgtgccgcca gctctggcct gatgaccaag      660

aaaaacagca ccttcgtgcg ggtgcacgag aaggacaaga cccacacctg tcctccatgt      720

cctgctccag aactgctcgg cggaccttcc gtgttcctgt ttcctccaaa gcctaaggac      780

accctgatga tcagcagaac ccctgaagtg acctgcgtgg tggtggatgt gtcccacgag      840

gatcccgaag tgaagttcaa ctggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      900

aagcctagag aggaacagta caatagcacc tacagagtgg tgtccgtgct gaccgtgctg      960

caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct     1020

gctcctatcg agaaaaccat ctccaaggcc aagggccagc ccagggaacc ccaggtttac     1080

acactgcctc caagcaggga cgagctgaca aagaaccagg tgtccctgac ctgcctggtc     1140

aagggcttct acccttccga tatcgccgtg gaatgggaga gcaatggcca gcctgagaac     1200

aactacaaga caacccctcc tgtgctggac agcgacggct cattcttcct gtacagcaag     1260

ctgacagtgg acaagagcag atggcagcag ggaaacgtgt tcagctgcag cgtgatgcac     1320

gaggccctgc acaaccacta cacccagaag tccctgagcc tgtctcctgg caagtga        1377


<210> 15
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 15
atggtcagct attgggatac gggcgtcctc ctttgtgccc ttctgagttg tctcttgttg       60

acgggaagta gttccggaag tgacactggc cgaccatttg tagaaatgta cagtgagatc      120

ccggaaatca tccacatgac cgaaggccgg gagttggtta taccatgccg ggtgacatcc      180

ccgaacatta ccgttacact gaagaaattc ccattggaca ctttgatacc tgatggaaag      240

agaatcatct gggattccag aaaaggcttt attatctcaa atgctacata caaagaaatc      300

ggtcttctta cgtgtgaagc aaccgtgaat ggtcatttgt acaagactaa ctacctcacc      360

cacaggcaga ccaatacaat aatcgacgtc gttctcagcc cctcccacgg aattgagctt      420

agtgtggggg agaaattggt cttgaattgt accgcccgga cagagttgaa tgttggcatt      480

gacttcaatt gggagtatcc atctagtaag caccaacaca aaaagcttgt taatcgggac      540

ctgaagactc aaagcggatc agaaatgaaa aagtttctct caacgttgac aatagacggc      600

gtgacgcgct ctgatcaggg tctttacacc tgcgctgcca gctctgggtt gatgacgaaa      660

aaaaattcta catttgtgcg ggttcatgaa aaagataaga cacatacctg tcccccgtgt      720

ccagcgccgg aattgcttgg gggccccagc gtattccttt tcccccccaa gcctaaagac      780

acgctcatga tctctagaac gccggaggtc acctgtgtgg tggtggacgt gtctcatgaa      840

gatcccgagg ttaaattcaa ttggtacgta gatggagtcg aagttcacaa tgcaaagaca      900

aagccgagag aagagcagta caatagcacc taccgagttg taagtgtact tactgtcctg      960

caccaagatt ggttgaatgg aaaagagtat aagtgtaagg tctcaaataa ggcactccca     1020

gctcccatag aaaaaacgat atctaaagcg aagggtcagc ccagagagcc tcaagtgtac     1080

acgctccctc cctcacggga tgagctgaca aaaaaccagg tttcactgac ttgtttggta     1140

aagggttttt atccatctga catcgctgtc gagtgggaaa gcaatggtca accggagaac     1200

aactataaga caaccccccc ggttctcgat tcagatggct ccttcttcct ctattctaag     1260

ctcactgttg ataaatctcg gtggcaacaa gggaatgttt tctcttgctc tgttatgcac     1320

gaagcattgc ataatcatta tacacaaaaa tctctttccc ttagtccagg taaatga        1377


<210> 16
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 16
atggtgtcct actgggacac aggggtgctg ctgtgtgccc tgctgtcttg tctgctgctg       60

actggctcta gctctggctc tgacacaggc agaccctttg tggaaatgta ctctgagatc      120

cctgagatca tccacatgac agagggcaga gagctggtca tcccctgcag agtgacaagc      180

cccaacatca cagtgaccct gaagaagttc cctctggaca cactgatccc tgatggcaag      240

agaatcatct gggacagcag aaagggcttc atcatcagca atgccaccta caaagagatt      300

ggcctgctga cctgtgaagc cacagtgaat ggccacctgt acaagaccaa ctacctgaca      360

cacagacaga ccaacaccat cattgatgtg gtgctgagcc ccagccatgg cattgagctg      420

tctgtgggag agaagctggt gctgaactgc acagccagaa cagagctgaa tgtgggcatt      480

gacttcaact gggagtaccc cagcagcaag caccagcaca agaaactggt caacagggac      540

ctgaaaaccc agagtggctc tgagatgaag aaattcctga gcaccctgac cattgatggg      600

gtcaccagat ctgaccaggg cctgtacaca tgtgctgcca gctctggact gatgaccaag      660

aaaaacagca cctttgtcag agtgcatgag aaggacaaga cccacacctg tcctccatgt      720

cctgcacctg agctgcttgg aggcccctct gtgttcctgt ttcctccaaa gcctaaggac      780

accctgatga tcagcagaac acctgaagtg acctgtgtgg tggtggatgt gtcccatgag      840

gacccagaag tgaagttcaa ttggtatgtg gatggggttg aagtgcacaa tgccaagacc      900

aagcctagag aggaacagta caactccacc tacagagtgg tgtcagtgct gacagtgctg      960

caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct     1020

gctcctattg agaaaaccat ctccaaggcc aagggccagc ctagggaacc ccaggtttac     1080

acactgccac ctagcaggga tgagctgaca aagaaccagg tgtccctgac ctgcctggtc     1140

aagggcttct acccctctga cattgctgtg gaatgggaga gcaatggcca gcctgagaac     1200

aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct gtacagcaag     1260

ctgactgtgg acaagagcag atggcagcag ggaaatgtgt tcagctgctc tgtgatgcat     1320

gaggccctgc acaaccacta cacccagaaa agcctgagcc tgtctcctgg caagtga        1377


<210> 17
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 17
atggtttctt actgggatac cggcgtgctg ctgtgtgccc tgctgtcttg tctgctgctg       60

accggctcta gcagcggctc tgataccggc agacccttcg tggaaatgta cagcgagatc      120

cccgagatca tccacatgac cgagggcaga gagctggtca tcccctgcag agtgacaagc      180

cccaacatca ccgtgactct gaagaagttc cctctggaca cactgatccc cgacggcaag      240

agaatcatct gggacagccg gaagggcttc atcatcagca acgccaccta caaagagatc      300

ggcctgctga cctgtgaagc caccgtgaat ggccacctgt acaagaccaa ctacctgaca      360

cacagacaga ccaacaccat catcgacgtg gtgctgagcc ctagccacgg cattgaactg      420

tctgtgggcg agaagctggt gctgaactgt accgccagaa ccgagctgaa cgtgggcatc      480

gacttcaact gggagtaccc cagcagcaag caccagcaca agaaactggt caaccgggac      540

ctgaaaaccc agagcggcag cgagatgaag aaattcctga gcaccctgac catcgacggc      600

gtgaccaggt ctgaccaggg cctgtacaca tgtgccgcca gctctggcct gatgaccaag      660

aaaaacagca ccttcgtgcg ggtgcacgag aaggacaaga cccacacctg tcctccatgt      720

cctgctccag aactgctcgg cggaccttcc gtgttcctgt ttcctccaaa gcctaaggac      780

accctgatga tcagcagaac ccctgaagtg acctgcgtgg tggtggatgt gtcccacgag      840

gatcccgaag tgaagttcaa ctggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      900

aagcctagag aggaacagta caatagcacc tacagagtgg tgtccgtgct gaccgtgctg      960

caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct     1020

gctcctatcg agaaaaccat ctccaaggcc aagggccagc ccagggaacc ccaggtttac     1080

acactgcctc caagcaggga cgagctgaca aagaaccagg tgtccctgac ctgcctggtc     1140

aagggcttct acccttccga tatcgccgtg gaatgggaga gcaatggcca gcctgagaac     1200

aactacaaga caacccctcc tgtgctggac agcgacggct cattcttcct gtacagcaag     1260

ctgacagtgg acaagagcag atggcagcag ggaaacgtgt tcagctgcag cgtgatgcac     1320

gaggccctgc acaaccacta cacccagaag tccctgagcc tgtctcctgg caagtga        1377


<210> 18
<211> 1377
<212> DNA
<213> Homo sapiens

<400> 18
atggtgtcct actgggatac aggcgtgctg ctgtgtgccc tgctgtcttg tctgctgctg       60

accggctcta gcagcggctc tgataccggc agacccttcg tggaaatgta cagcgagatc      120

cccgagatca tccacatgac cgagggcaga gagctggtca tcccctgcag agtgacaagc      180

cccaacatca ccgtgactct gaagaagttc cctctggaca cactgatccc cgacggcaag      240

agaatcatct gggacagccg gaagggcttc atcatcagca acgccaccta caaagagatc      300

ggcctgctga cctgtgaagc caccgtgaat ggccacctgt acaagaccaa ctacctgaca      360

cacagacaga ccaacaccat catcgacgtg gtgctgagcc ctagccacgg cattgaactg      420

tctgtgggcg agaagctggt gctgaactgt accgccagaa ccgagctgaa cgtgggcatc      480

gacttcaact gggagtaccc cagcagcaag caccagcaca agaaactggt caaccgggac      540

ctgaaaaccc agagcggcag cgagatgaag aaattcctga gcaccctgac catcgacggc      600

gtgaccagat ctgaccaggg cctgtacaca tgtgccgcca gctctggcct gatgaccaag      660

aaaaacagca ccttcgtgcg ggtgcacgag aaggacaaga cccacacctg tcctccatgt      720

cctgctccag aactgctcgg cggaccttcc gtgttcctgt ttcctccaaa gcctaaggac      780

accctgatga tcagcagaac ccctgaagtg acctgcgtgg tggtggatgt gtcccacgag      840

gatcccgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      900

aagcctagag aggaacagta caatagcacc tacagagtgg tgtccgtgct gaccgtgctg      960

caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct     1020

gctcctatcg agaaaaccat ctccaaggcc aagggccagc ctagggaacc ccaggtttac     1080

acactgcctc caagcaggga cgagctgaca aagaaccagg tgtccctgac ctgcctggtc     1140

aagggcttct acccttccga tatcgccgtg gaatgggaga gcaatggcca gcctgagaac     1200

aactacaaga caacccctcc tgtgctggac agcgacggct cattcttcct gtacagcaag     1260

ctgacagtgg acaagagcag atggcagcag ggaaacgtgt tcagctgcag cgtgatgcac     1320

gaggccctgc acaaccacta cacccagaag tccctgagcc tgtctcctgg caagtga        1377


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Gly Gly Gly Ser 
1               5   


<210> 20
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


