SEQUENCE LISTING

<110> Cellectis S.A.

<120> T-CELLS EXPRESSING IMMUNE CELL ENGAGERS IN ALLOGENIC SETTINGS

<130> P242950PC00

<150> US 63/056,293
<151> 2020-07-24

<150> PA 202070731
<151> 2020-11-04

<160> 55

<170> PatentIn version 3.5

<210>  1

<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR signal peptide

<400>  1
Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro 
            20  


<210>  2

<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alternative signal peptide

<400>  2
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  3

<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc&#947;RIII&#945; hinge

<400>  3
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
1               5                   10                  15      






<210>  4

<211>  45
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD8&#945; hinge

<400>  4
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  5

<211>  231
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1 hinge

<400>  5
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  6

<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD8&#945; transmembrane domain

<400>  6
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  7

<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  4-1BB transmembrane domain 

<400>  7
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  8

<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  4-1BB stimulatory domain

<400>  8
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9

<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  CD3&#950; signalling domain

<400>  9
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         






<210>  10

<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  10
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  11

<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123 VH

<400>  11
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125         


<210>  12

<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123 VL

<400>  12
Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  13

<211>  499
<212>  PRT
<213>  artificial sequence

<220>
<223>  123CAR

<400>  13
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  14

<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  CS1 VH

<400>  14
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  15

<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  CS1 VL

<400>  15
Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  16

<211>  486
<212>  PRT
<213>  artificial sequence

<220>
<223>  CS1CAR

<400>  16
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
            20                  25                  30          


Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Thr Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg 
65                  70                  75                  80  


Leu Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Gln Lys Ser Met Ser Thr Ser Val Gly Asp Arg Val Ser 
                165                 170                 175     


Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr Gly Val Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        195                 200                 205             


Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Phe Thr Ile Ser Asn Val Gln Ala Glu Asp Leu Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala 
                245                 250                 255     


Gly Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  17

<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  CLL1 VH

<400>  17
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asp Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  18

<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  CLL1 VL

<400>  18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Thr Gln Glu Leu Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Asn Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19

<211>  487
<212>  PRT
<213>  artificial sequence

<220>
<223>  CLL1CAR

<400>  19
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Phe Ile His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Phe Ile Asn Pro Tyr Asn Asp Gly Ser Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asp Gly Tyr Tyr Gly Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Glu Arg Val Ser 
                165                 170                 175     


Leu Thr Cys Arg Ala Thr Gln Glu Leu Ser Gly Tyr Leu Ser Trp Leu 
            180                 185                 190         


Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile Tyr Ala Ala Ser 
        195                 200                 205             


Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Asn Arg Ser Gly 
    210                 215                 220                 


Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Leu Gln Tyr Ala Ile Tyr Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  20

<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD22 VH

<400>  20
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  21

<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD22 VL

<400>  21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  22

<211>  490
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD22CAR

<400>  22
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
65                  70                  75                  80  


Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu 
        115                 120                 125             


Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        195                 200                 205             


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  23

<211>  925
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAC_T01-L

<400>  23
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  24

<211>  925
<212>  PRT
<213>  artificial sequence

<220>
<223>  TRAC_T01-R

<400>  24
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  25

<211>  925
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD52_T01-L

<400>  25
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  26

<211>  925
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD52_T01-R

<400>  26
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  27

<211>  925
<212>  PRT
<213>  artificial sequence

<220>
<223>  B2M_T01-L4

<400>  27
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  28

<211>  925
<212>  PRT
<213>  artificial sequence

<220>
<223>  B2M_T01-R4

<400>  28
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  29

<211>  902
<212>  PRT
<213>  artificial sequence

<220>
<223>  CS1_T01-L2

<400>  29
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg Ser Gln 
    690                 695                 700                 


Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys 
705                 710                 715                 720 


Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg 
                725                 730                 735     


Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe 
            740                 745                 750         


Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys 
        755                 760                 765             


Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val 
    770                 775                 780                 


Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly 
785                 790                 795                 800 


Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn 
                805                 810                 815     


Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val 
            820                 825                 830         


Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr 
        835                 840                 845             


Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala 
    850                 855                 860                 


Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala 
865                 870                 875                 880 


Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu 
                885                 890                 895     


Ile Asn Phe Ala Ala Asp 
            900         


<210>  30

<211>  902
<212>  PRT
<213>  artificial sequence

<220>
<223>  CS1_T01-R2

<400>  30
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg Ser Gln 
    690                 695                 700                 


Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys 
705                 710                 715                 720 


Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg 
                725                 730                 735     


Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe 
            740                 745                 750         


Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys 
        755                 760                 765             


Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val 
    770                 775                 780                 


Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly 
785                 790                 795                 800 


Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn 
                805                 810                 815     


Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val 
            820                 825                 830         


Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr 
        835                 840                 845             


Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala 
    850                 855                 860                 


Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala 
865                 870                 875                 880 


Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu 
                885                 890                 895     


Ile Asn Phe Ala Ala Asp 
            900         


<210>  31

<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  Signal Peptide IC engager (CLL1)

<400>  31
Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  32

<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Signal Peptide IC engager (Trop2

<400>  32
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  33

<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  T2A

<400>  33
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  34

<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  P2A

<400>  34
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  35

<211>  239
<212>  PRT
<213>  artificial sequence

<220>
<223>  IC engager CD3 scFv

<400>  35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Ser Val 
        35                  40                  45              


Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Pro Ala 
    130                 135                 140                 


Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asp Ile 
145                 150                 155                 160 


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser Phe Thr Ile Ser Ser 
        195                 200                 205             


Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys Gln Gln Tyr Tyr Asn 
    210                 215                 220                 


Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235                 


<210>  36

<211>  240
<212>  PRT
<213>  artificial sequence

<220>
<223>  IC engager CD16 scFv

<400>  36
Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 






<210>  37

<211>  490
<212>  PRT
<213>  artificial sequence

<220>
<223>  IC engagers TRop2 ScFv

<400>  37
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys 
145                 150                 155                 160 


Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr 
                165                 170                 175     


Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe Lys Gly Arg Phe Ala Phe 
            180                 185                 190         


Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu 
        195                 200                 205             


Lys Ala Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Gly Phe Gly 
    210                 215                 220                 


Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly 
                245                 250                 255     


Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr 
            260                 265                 270         


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg 
        275                 280                 285             


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
    290                 295                 300                 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr 
305                 310                 315                 320 


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
                325                 330                 335     


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
            340                 345                 350         


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val 
        355                 360                 365             


Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val 
    370                 375                 380                 


Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
385                 390                 395                 400 


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
                405                 410                 415     


Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
            420                 425                 430         


Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly 
        435                 440                 445             


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
    450                 455                 460                 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu 
465                 470                 475                 480 


Thr Phe Gly Ala Gly Thr Lys Leu Glu Lys 
                485                 490 


<210>  38

<211>  487
<212>  PRT
<213>  artificial sequence

<220>
<223>  CLL1-CD3 BiTE

<400>  38
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asp Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala 
145                 150                 155                 160 


Thr Gln Glu Leu Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp 
                165                 170                 175     


Gly Thr Ile Lys Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly 
            180                 185                 190         


Val Pro Lys Arg Phe Ser Gly Asn Arg Ser Gly Ser Asp Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu 
    210                 215                 220                 


Gln Tyr Ala Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala 
            260                 265                 270         


Ser Gly Phe Thr Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Arg Gly Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile 
    290                 295                 300                 


Asn Ile Lys Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg 
305                 310                 315                 320 


Asp Asn Ala Lys Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser 
                325                 330                 335     


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    370                 375                 380                 


Gln Ser Pro Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile 
385                 390                 395                 400 


Asn Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
                405                 410                 415     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys 
            420                 425                 430         


Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg 
        435                 440                 445             


Asp Ser Ser Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser 
    450                 455                 460                 


Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly 
465                 470                 475                 480 


Thr Lys Leu Glu Ile Lys Arg 
                485         


<210>  39

<211>  1094
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD123CAR-CLL1BiTE (pCLS35091)

<400>  39
Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro Glu Ser Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
            20                  25                  30          


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Glu Val Lys Leu Val Glu 
        35                  40                  45              


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys 
    50                  55                  60                  


Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg 
65                  70                  75                  80  


Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys 
                85                  90                  95      


Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe 
            100                 105                 110         


Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn 
        115                 120                 125             


Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala 
    130                 135                 140                 


Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly 
145                 150                 155                 160 


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Glu Ser Ala Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val 
            180                 185                 190         


Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
        195                 200                 205             


Asn Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp 
    210                 215                 220                 


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala 
225                 230                 235                 240 


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser 
                245                 250                 255     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
            260                 265                 270         


Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly 
        275                 280                 285             


Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Cys 
305                 310                 315                 320 


Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Thr Thr 
                325                 330                 335     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            340                 345                 350         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        355                 360                 365             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    370                 375                 380                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
385                 390                 395                 400 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                405                 410                 415     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            420                 425                 430         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        435                 440                 445             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    450                 455                 460                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
465                 470                 475                 480 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                485                 490                 495     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            500                 505                 510         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        515                 520                 525             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    530                 535                 540                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
545                 550                 555                 560 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
                565                 570                 575     


Pro Gly Pro Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu 
            580                 585                 590         


Pro His Pro Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Gln Gln Ser 
        595                 600                 605             


Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    610                 615                 620                 


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Phe Ile His Trp Val Lys Gln 
625                 630                 635                 640 


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Phe Ile Asn Pro Tyr Asn 
                645                 650                 655     


Asp Gly Ser Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
            660                 665                 670         


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
        675                 680                 685             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Asp Asp Gly Tyr Tyr 
    690                 695                 700                 


Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
705                 710                 715                 720 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                725                 730                 735     


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
            740                 745                 750         


Glu Arg Val Ser Leu Thr Cys Arg Ala Thr Gln Glu Leu Ser Gly Tyr 
        755                 760                 765             


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
    770                 775                 780                 


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
785                 790                 795                 800 


Asn Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
                805                 810                 815     


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ile Tyr Pro Tyr 
            820                 825                 830         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Gly 
        835                 840                 845             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    850                 855                 860                 


Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Gly 
865                 870                 875                 880 


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Ser 
                885                 890                 895     


Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp Ala 
            900                 905                 910         


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu Leu 
        915                 920                 925             


Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
    930                 935                 940                 


Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln Gly Thr Met 
945                 950                 955                 960 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Pro 
            980                 985                 990         


Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asp 
        995                 1000                1005            


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    1010                1015                1020                


Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp Gly Val Pro Ser 
1025                1030                1035                1040


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser Phe Thr Ile Ser 
                1045                1050                1055    


Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys Gln Gln Tyr Tyr 
            1060                1065                1070        


Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys Arg 
        1075                1080                1085            


His His His His His His 
    1090                


<210>  40

<211>  1094
<212>  PRT
<213>  artificial sequence

<220>
<223>  CLL1BiTE-CD123CAR pCLS35092

<400>  40
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro Met Val Leu Leu Val Thr Ser Leu Leu Leu 
            20                  25                  30          


Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Glu Val Gln Leu 
        35                  40                  45              


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met 
    50                  55                  60                  


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Phe Ile His Trp 
65                  70                  75                  80  


Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Phe Ile Asn 
                85                  90                  95      


Pro Tyr Asn Asp Gly Ser Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
            100                 105                 110         


Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
        115                 120                 125             


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Asp Asp 
    130                 135                 140                 


Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
145                 150                 155                 160 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            180                 185                 190         


Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Thr Gln Glu Leu 
        195                 200                 205             


Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys 
    210                 215                 220                 


Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg 
225                 230                 235                 240 


Phe Ser Gly Asn Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser 
                245                 250                 255     


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ile 
            260                 265                 270         


Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 
        275                 280                 285             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    290                 295                 300                 


Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr 
305                 310                 315                 320 


Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly 
                325                 330                 335     


Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr 
            340                 345                 350         


Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys 
        355                 360                 365             


Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala 
    370                 375                 380                 


Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            420                 425                 430         


Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln Ala 
        435                 440                 445             


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser Phe 
                485                 490                 495     


Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Lys Arg His His His His His His Ser Gly Glu Gly Arg Gly Ser 
    530                 535                 540                 


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Glu Ser Ala 
545                 550                 555                 560 


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
                565                 570                 575     


Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            580                 585                 590         


Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        595                 600                 605             


Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    610                 615                 620                 


Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu 
625                 630                 635                 640 


Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser 
                645                 650                 655     


Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser 
            660                 665                 670         


Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser 
        675                 680                 685             


Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    690                 695                 700                 


Ser Ser Gly Gly Gly Glu Ser Ala Gly Gly Gly Ser Gly Gly Gly Gly 
705                 710                 715                 720 


Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe 
                725                 730                 735     


Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser 
            740                 745                 750         


Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        755                 760                 765             


Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val 
    770                 775                 780                 


Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr 
785                 790                 795                 800 


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                805                 810                 815     


Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            820                 825                 830         


Lys Arg Gly Ser Gly Gly Gly Gly Ser Cys Pro Tyr Ser Asn Pro Ser 
        835                 840                 845             


Leu Cys Ser Gly Gly Gly Gly Ser Cys Pro Tyr Ser Asn Pro Ser Leu 
    850                 855                 860                 


Cys Ser Gly Gly Gly Gly Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
865                 870                 875                 880 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
                885                 890                 895     


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
            900                 905                 910         


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
        915                 920                 925             


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
    930                 935                 940                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
945                 950                 955                 960 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                965                 970                 975     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            980                 985                 990         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        995                 1000                1005            


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    1010                1015                1020                


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
1025                1030                1035                1040


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                1045                1050                1055    


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            1060                1065                1070        


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        1075                1080                1085            


Gln Ala Leu Pro Pro Arg 
    1090                


<210>  41

<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD19 scFv

<400>  41
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala 
    130                 135                 140                 


Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg 
145                 150                 155                 160 


Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 
                165                 170                 175     


Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met 
            180                 185                 190         


Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val 
    210                 215                 220                 


Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp 
                245                 250     


<210>  42

<211>  504
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD19-CD3 BiTE

<400>  42
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 
145                 150                 155                 160 


Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 
                165                 170                 175     


Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 
        195                 200                 205             


Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
    210                 215                 220                 


Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
        275                 280                 285             


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
305                 310                 315                 320 


Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met 
                325                 330                 335     


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro 
385                 390                 395                 400 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
                405                 410                 415     


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly 
            420                 425                 430         


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly 
        435                 440                 445             


Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
    450                 455                 460                 


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
                485                 490                 495     


Leu Lys His His His His His His 
            500                 


<210>  43

<211>  1028
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD22CARxCD19BiTE

<400>  43
Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
        35                  40                  45              


Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser 
    50                  55                  60                  


Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr 
65                  70                  75                  80  


Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr 
        195                 200                 205             


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
                485                 490                 495     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
        515                 520                 525             


Phe Leu Leu Ile Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
    530                 535                 540                 


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
545                 550                 555                 560 


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
                565                 570                 575     


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
            580                 585                 590         


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
        595                 600                 605             


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
625                 630                 635                 640 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
            660                 665                 670         


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
        675                 680                 685             


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
    690                 695                 700                 


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
705                 710                 715                 720 


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
                725                 730                 735     


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
            740                 745                 750         


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
        755                 760                 765             


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp 
    770                 775                 780                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
785                 790                 795                 800 


Val Gln Pro Gly Lys Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe 
                805                 810                 815     


Thr Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Arg 
            820                 825                 830         


Gly Leu Glu Ser Val Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys 
        835                 840                 845             


Tyr Ala Asp Ala Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
    850                 855                 860                 


Lys Asn Leu Leu Phe Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr 
865                 870                 875                 880 


Ala Met Tyr Tyr Cys Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly 
                885                 890                 895     


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            900                 905                 910         


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
        915                 920                 925             


Ser Ser Leu Pro Ala Ser Leu Gly Asp Arg Val Thr Ile Asn Cys Gln 
    930                 935                 940                 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
945                 950                 955                 960 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Asn Lys Leu Ala Asp 
                965                 970                 975     


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Ser Ser 
            980                 985                 990         


Phe Thr Ile Ser Ser Leu Glu Ser Glu Asp Ile Gly Ser Tyr Tyr Cys 
        995                 1000                1005            


Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Pro Gly Thr Lys Leu 
    1010                1015                1020                


Glu Ile Lys Arg 
1025            


<210>  44

<211>  242
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD40_scFv1

<400>  44
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Pro Phe His Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
        115                 120                 125             


Ser Gly Glu Gly Ser Thr Lys Asp Ile Gln Met Thr Gln Thr Thr Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
                165                 170                 175     


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ile Leu His Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
        195                 200                 205             


Thr Ile Gly Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Phe Asn Lys Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  45

<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD40_scFv2

<400>  45
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Gly Val Lys Lys Pro Gly 
1               5                   10                  15      


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Asp Pro Ser Asn Gly Glu Thr His Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Gly Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Ile Tyr Tyr Ser Gly Ser Thr Tyr Asp Gly Tyr 
            100                 105                 110         


Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ser 
        115                 120                 125             


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Asp 
    130                 135                 140                 


Ile Gln Leu Thr Gln Ser Pro Ser Pro Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Leu Ser Tyr Met His 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Arg Trp Ile Tyr Asp 
            180                 185                 190         


Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Trp Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  46

<211>  1800
<212>  DNA
<213>  homo sapiens

<220>
<223>  trac target region

<400>  46
tgctaatgcc cagcctaagt tggggagacc actccagatt ccaagatgta cagtttgctt     60
tgctgggcct ttttcccatg cctgccttta ctctgccaga gttatattgc tggggttttg    120
aagaagatcc tattaaataa aagaataagc agtattatta agtagccctg catttcaggt    180
ttccttgagt ggcaggccag gcctggccgt gaacgttcac tgaaatcatg gcctcttggc    240
caagattgat agcttgtgcc tgtccctgag tcccagtcca tcacgagcag ctggtttcta    300
agatgctatt tcccgtataa agcatgagac cgtgacttgc cagccccaca gagccccgcc    360
cttgtccatc actggcatct ggactccagc ctgggttggg gcaaagaggg aaatgagatc    420
atgtcctaac cctgatcctc ttgtcccaca gatatccaga accctgaccc tgccgtgtac    480
cagctgagag actctaaatc cagtgacaag tctgtctgcc tattcaccga ttttgattct    540
caaacaaatg tgtcacaaag taaggattct gatgtgtata tcacagacaa aactgtgcta    600
gacatgaggt ctatggactt caagagcaac agtgctgtgg cctggagcaa caaatctgac    660
tttgcatgtg caaacgcctt caacaacagc attattccag aagacacctt cttccccagc    720
ccaggtaagg gcagctttgg tgccttcgca ggctgtttcc ttgcttcagg aatggccagg    780
ttctgcccag agctctggtc aatgatgtct aaaactcctc tgattggtgg tctcggcctt    840
atccattgcc accaaaaccc tctttttact aagaaacagt gagccttgtt ctggcagtcc    900
agagaatgac acgggaaaaa agcagatgaa gagaaggtgg caggagaggg cacgtggccc    960
agcctcagtc tctccaactg agttcctgcc tgcctgcctt tgctcagact gtttgcccct   1020
tactgctctt ctaggcctca ttctaagccc cttctccaag ttgcctctcc ttatttctcc   1080
ctgtctgcca aaaaatcttt cccagctcac taagtcagtc tcacgcagtc actcattaac   1140
ccaccaatca ctgattgtgc cggcacatga atgcaccagg tgttgaagtg gaggaattaa   1200
aaagtcagat gaggggtgtg cccagaggaa gcaccattct agttggggga gcccatctgt   1260
cagctgggaa aagtccaaat aacttcagat tggaatgtgt tttaactcag ggttgagaaa   1320
acagctacct tcaggacaaa agtcagggaa gggctctctg aagaaatgct acttgaagat   1380
accagcccta ccaagggcag ggagaggacc ctatagaggc ctgggacagg agctcaatga   1440
gaaaggagaa gagcagcagg catgagttga atgaaggagg cagggccggg tcacagggcc   1500
ttctaggcca tgagagggta gacagtattc taaggacgcc agaaagctgt tgatcggctt   1560
caagcagggg agggacacct aatttgcttt tctttttttt tttttttttt tttttttttt   1620
ttgagatgga gttttgctct tgttgcccag gctggagtgc aatggtgcat cttggctcac   1680
tgcaacctcc gcctcccagg ttcaagtgat tctcctgcct cagcctcccg agtagctgag   1740
attacaggca cccgccacca tgcctggcta attttttgta tttttagtag agacagggtt   1800

<210>  47

<211>  467
<212>  DNA
<213>  human

<220>
<223>  cd52 target region

<400>  47
agacagccct gagatcacct aaaaagctgc taccaagaca gccacgaaga tcctaccaaa     60
atgaagcgct tcctcttcct cctactcacc atcagcctcc tggttatggt acagatacaa    120
actggactct caggacaaaa cgacaccagc caaaccagca gcccctcagc atccagcaac    180
ataagcggag gcattttcct tttcttcgtg gccaatgcca taatccacct cttctgcttc    240
agttgaggtg acacgtctca gccttagccc tgtgccccct gaaacagctg ccaccatcac    300
tcgcaagaga atcccctcca tctttgggag gggttgatgc cagacatcac caggttgtag    360
aagttgacag gcagtgccat gggggcaaca gccaaaatag gggggtaatg atgtaggggc    420
caagcagtgc ccagctgggg gtcaataaag ttacccttgt acttgca                  467


<210>  48

<211>  14398
<212>  DNA
<213>  human

<220>
<223>  b2m target region

<400>  48
ttaaactgct gacaacttaa cactgattac tcatagaggc actgccatgg tggtcttgga     60
taagatctgg aagaattctc tggattacca ggcagagact cttattgtct tcccttattt    120
tcccccaggc aaagtctgct ttctgtgatc agctgcctgg agttggggga gaagtgacac    180
aaacacccct gtgaccacca ctgggactgt gcagggtcag acgtgaagcc agcatagtac    240
tgggtcttgc ccaaggccta tggtaaccac cgcctggcta ctacctatgt tcactcaagg    300
ccctatggct ctaaaatcag caggtggcaa agccagccaa gcttatgtcc ctctctttag    360
ggtggcaagt ttcccccagc ctggggtgaa tccagagatg ccttccagga actggggcct    420
agtcagaaac cttaggaatc tacctggtac tctattgcac tgaggctgaa ctggcaccca    480
agccacaaga caaagtcctt cccacttttc cctccccttt ccacaagctg aggagtctct    540
tgccatggcc acttccaccc caggcctgtg gtgggtactg tctggctact gctgatgtat    600
actcaaggcc caagggctct gcagtaagct tgtggtgaac gctgcccagc ctgggactca    660
cccttcaggg aagcaggctc ccctctggcc cagagcaggt ccaggaatgc tatctaagag    720
ccaaagcctg gaatcaggga ccttaagagg ccacttggta ttctaacccc acagtggcca    780
agtccccttt actctttcca cttcttttct caagcagaag gaatttctcc ccatagccac    840
cacagctgta atgtgctggg tcacacctta agcctgcacg tctctgagtc tcacccaaag    900
cccatgatga gtactacctg gctacttctg attattcagg gccaaagggc tctttagtca    960
gctggtgagg aatcctgcca ggactggtcc ttcccttcaa ggcagcaggt tcccttctgg   1020
cccagggtgt ggctagaaat gtcagcttgg agctatggcc tggaatgtgg gcctcaggac   1080
tttgcctggt gccctatcct actgcagctg agctggtatc caatgcaaga caaactcatc   1140
tttgttcttc cctctcctct tctcaagcag aggaaagaag tctctctctg agctttgagc   1200
tgccctgcct ggggttggga gaggggtggt gcaagcaatc ccttggccat cccagctagt   1260
gtctcactag gttgtgtgcc ccccacattc actggctctg agcccagcac agcaccagga   1320
cttacccagg aattgccatc cttgtggcct agactgcctt tcaagtttat gtagaacctc   1380
agagcacttc agcccatggt ggggaggctt actggaactc aggttcccac tgctgggatg   1440
ggtgatttgc ctctagctag ggctggtcta aatgatccct ccatgggacc tgggtgagtt   1500
cttcccagtg ttgctttgtg ctatgactgg gcagcactga gttccaatgc aaagtctgaa   1560
aatcactgca ctcttcctct cccagaagca cacattctct ctccatgcca ggtggccgct   1620
gccggcgaat gggggagaga tagcatttag caattcaaga ctgtcttacc ctcttcagtt   1680
actctttcag tgatacgaag ttaaaaccag gtactgtgat cactcacctg atttttggtt   1740
cttatgaagg tgcttttttt tgtgtggatc attattcaat ttggtgttcc tgcagggagc   1800
aggattagtg gaggcgtcta ttcagccatc ttgctccacc tcccctagct atgtcctttt   1860
aaatatttat aatcgacata caatatatta cacttaaagt atacaataag ttctaaaata   1920
taactgaaat catcatcgaa ctctagataa ttaacatatc catcaaccct aaagtttcct   1980
catgtttaga tgatctcctt tccctctaga aaccactcat ctactttctg tcatatagat   2040
tatagtttgc cttttctgga gttttatata aacagaatca tatagtatat gttcttttct   2100
gtctgacttc ttttatttac catgattatt tcatccatgt tacatgtatc aacagtttat   2160
tccttgtttg ttgatgatag tatttcattg tatggatata tactccaatg ggtttattca   2220
tttacctgtt gatgtatgtt ggatcgtttc tagttttcag ctatcacaaa taaaactgct   2280
ataaacatta aacattaatg tccaagtctt tgtatagaca tatgctttca ttttctcttg   2340
ggcaaatacc ttgggtggag tggctggata ttatggccag tgtatgttta actttataaa   2400
gagctgtcga agtgttttcc tttttctttt ttctttttga gatgaagtct tgctctgttg   2460
cccaggctgg agtgcagtgg tgcaatctcg gctcattgca acctctgcct cccaggttca   2520
agcaattctc ctgcctcagc ctcctgagta gttggggtta cagatgcctg ccaccatgcc   2580
tagctaattt ttgtattttt agtagagaca gggtttcacc atgttggcca ggctggtctc   2640
aaactcctga tctcaagtga tctgcccgcc ttgacctccc aaagtgctca gattacaggt   2700
gtgagccacc acatccagcc ccaaattgtt tataccattt tatattccta ccaggattgt   2760
atgagagttc cagttcttct aaattcttgc caacatttac tactttgaat aaatgttcat   2820
tgtaaaaaaa ttttaagagg gttatatagg ggaaaaaaag gccgctatta atctgttaat   2880
tgcactactg ggagataaag ctattaaact gtcatatttg tggctgggcg tggtaacaca   2940
tgcttgtgat cctagcactt taggaggctg gggaaggagg atcacttgag accaggagtt   3000
cgagaccagc ctgggcaaca cagcaagact ctgtctccac aaaaatatta aaaattaaaa   3060
aaaaaagaaa ttgtcatgtt tgtagacttc ccaaatttgc catcctaggc aaacagtgct   3120
cttgttttta aacaaatagt tgtatacata attttccccc tcactattca aaacatgtca   3180
taaatggtaa gtccaagaaa aatacaggta ttccccccca aagaaaactg taaaatcgac   3240
ttttttctat ctgtactgtt ttttattggt ttttaaattg gttttccaag tgagtaaatc   3300
agaatctatc tgtaatggat tttaaattta gtgtttctct gtgatgtagt aaacaagaaa   3360
ctagaggcaa aaatagccct gtcccttgct aaacttctaa ggcacttttc tagtacaact   3420
caacactaac atttcaggcc tttagtgcct tatatgagtt tttaaaaggg ggaaaaggga   3480
gggagcaaga gtgtcttaac tcatacattt aggcataaca attattctca tattttagtt   3540
attgagaggg ctggtagaaa aactaggtaa ataatattaa taattatagc gcttattaaa   3600
cactacagaa cacttactat gtaccaggca ttgtgggagg ctctctcttg tgcattatct   3660
catttcatta ggtccatgga gagtattgca ttttcttagt ttaggcatgg cctccacaat   3720
aaagattatc aaaagcctaa aaatatgtaa aagaaaccta gaagttattt gttgtgctcc   3780
ttggggaagc taggcaaatc ctttcaactg aaaaccatgg tgacttccaa gatctctgcc   3840
cctccccatc gccatggtcc acttcctctt ctcactgttc ctcttagaaa agatctgtgg   3900
actccaccac cacgaaatgg cggcacctta tttatggtca ctttagaggg taggttttct   3960
taatgggtct gcctgtcatg tttaacgtcc ttggctgggt ccaaggcaga tgcagtccaa   4020
actctcacta aaattgccga gccctttgtc ttccagtgtc taaaatatta atgtcaatgg   4080
aatcaggcca gagtttgaat tctagtctct tagcctttgt ttcccctgtc cataaaatga   4140
atgggggtaa ttctttcctc ctacagttta tttatatatt cactaattca ttcattcatc   4200
catccattcg ttcattcggt ttactgagta cctactatgt gccagcccct gttctagggt   4260
ggaaactaag agaatgatgt acctagaggg cgctggaagc tctaaagccc tagcagttac   4320
tgcttttact attagtggtc gtttttttct cccccccgcc ccccgacaaa tcaacagaac   4380
aaagaaaatt acctaaacag caaggacata gggaggaact tcttggcaca gaactttcca   4440
aacacttttt cctgaaggga tacaagaagc aagaaaggta ctctttcact aggaccttct   4500
ctgagctgtc ctcaggatgc ttttgggact atttttctta cccagagaat ggagaaaccc   4560
tgcagggaat tcccaagctg tagttataaa cagaagttct ccttctgcta ggtagcattc   4620
aaagatctta atcttctggg tttccgtttt ctcgaatgaa aaatgcaggt ccgagcagtt   4680
aactggctgg ggcaccatta gcaagtcact tagcatctct ggggccagtc tgcaaagcga   4740
gggggcagcc ttaatgtgcc tccagcctga agtcctagaa tgagcgcccg gtgtcccaag   4800
ctggggcgcg caccccagat cggagggcgc cgatgtacag acagcaaact cacccagtct   4860
agtgcatgcc ttcttaaaca tcacgagact ctaagaaaag gaaactgaaa acgggaaagt   4920
ccctctctct aacctggcac tgcgtcgctg gcttggagac aggtgacggt ccctgcgggc   4980
cttgtcctga ttggctgggc acgcgtttaa tataagtgga ggcgtcgcgc tggcgggcat   5040
tcctgaagct gacagcattc gggccgagat gtctcgctcc gtggccttag ctgtgctcgc   5100
gctactctct ctttctggcc tggaggctat ccagcgtgag tctctcctac cctcccgctc   5160
tggtccttcc tctcccgctc tgcaccctct gtggccctcg ctgtgctctc tcgctccgtg   5220
acttcccttc tccaagttct ccttggtggc ccgccgtggg gctagtccag ggctggatct   5280
cggggaagcg gcggggtggc ctgggagtgg ggaagggggt gcgcacccgg gacgcgcgct   5340
acttgcccct ttcggcgggg agcaggggag acctttggcc tacggcgacg ggagggtcgg   5400
gacaaagttt agggcgtcga taagcgtcag agcgccgagg ttgggggagg gtttctcttc   5460
cgctctttcg cggggcctct ggctccccca gcgcagctgg agtgggggac gggtaggctc   5520
gtcccaaagg cgcggcgctg aggtttgtga acgcgtggag gggcgcttgg ggtctggggg   5580
aggcgtcgcc cgggtaagcc tgtctgctgc ggctctgctt cccttagact ggagagctgt   5640
ggacttcgtc taggcgcccg ctaagttcgc atgtcctagc acctctgggt ctatgtgggg   5700
ccacaccgtg gggaggaaac agcacgcgac gtttgtagaa tgcttggctg tgatacaaag   5760
cggtttcgaa taattaactt atttgttccc atcacatgtc acttttaaaa aattataaga   5820
actacccgtt attgacatct ttctgtgtgc caaggacttt atgtgctttg cgtcatttaa   5880
ttttgaaaac agttatcttc cgccatagat aactactatg gttatcttct gcctctcaca   5940
gatgaagaaa ctaaggcacc gagattttaa gaaacttaat tacacagggg ataaatggca   6000
gcaatcgaga ttgaagtcaa gcctaaccag ggcttttgcg ggagcgcatg ccttttggct   6060
gtaattcgtg catttttttt taagaaaaac gcctgccttc tgcgtgagat tctccagagc   6120
aaactgggcg gcatgggccc tgtggtcttt tcgtacagag ggcttcctct ttggctcttt   6180
gcctggttgt ttccaagatg tactgtgcct cttactttcg gttttgaaaa catgaggggg   6240
ttgggcgtgg tagcttacgc ctgtaatccc agcacttagg gaggccgagg cgggaggatg   6300
gcttgaggtc cgtagttgag accagcctgg ccaacatggt gaagcctggt ctctacaaaa   6360
aataataaca aaaattagcc gggtgtggtg gctcgtgcct gtggtcccag ctgctccggt   6420
ggctgaggcg ggaggatctc ttgagcttag gcttttgagc tatcatggcg ccagtgcact   6480
ccagcgtggg caacagagcg agaccctgtc tctcaaaaaa gaaaaaaaaa aaaaaagaaa   6540
gagaaaagaa aagaaagaaa gaagtgaagg tttgtcagtc aggggagctg taaaaccatt   6600
aataaagata atccaagatg gttaccaaga ctgttgagga cgccagagat cttgagcact   6660
ttctaagtac ctggcaatac actaagcgcg ctcacctttt cctctggcaa aacatgatcg   6720
aaagcagaat gttttgatca tgagaaaatt gcatttaatt tgaatacaat ttatttacaa   6780
cataaaggat aatgtatata tcaccaccat tactggtatt tgctggttat gttagatgtc   6840
attttaaaaa ataacaatct gatatttaaa aaaaaatctt attttgaaaa tttccaaagt   6900
aatacatgcc atgcatagac catttctgga agataccaca agaaacatgt aatgatgatt   6960
gcctctgaag gtctattttc ctcctctgac ctgtgtgtgg gttttgtttt tgttttactg   7020
tgggcataaa ttaatttttc agttaagttt tggaagctta aataactctc caaaagtcat   7080
aaagccagta actggttgag cccaaattca aacccagcct gtctgatact tgtcctcttc   7140
ttagaaaaga ttacagtgat gctctcacaa aatcttgccg ccttccctca aacagagagt   7200
tccaggcagg atgaatctgt gctctgatcc ctgaggcatt taatatgttc ttattattag   7260
aagctcagat gcaaagagct ctcttagctt ttaatgttat gaaaaaaatc aggtcttcat   7320
tagattcccc aatccacctc ttgatggggc tagtagcctt tccttaatga tagggtgttt   7380
ctagagagat atatctggtc aaggtggcct ggtactcctc cttctcccca cagcctccca   7440
gacaaggagg agtagctgcc ttttagtgat catgtaccct gaatataagt gtatttaaaa   7500
gaattttata cacatatatt tagtgtcaat ctgtatattt agtagcacta acacttctct   7560
tcattttcaa tgaaaaatat agagtttata atattttctt cccacttccc catggatggt   7620
ctagtcatgc ctctcatttt ggaaagtact gtttctgaaa cattaggcaa tatattccca   7680
acctggctag tttacagcaa tcacctgtgg atgctaatta aaacgcaaat cccactgtca   7740
catgcattac tccatttgat cataatggaa agtatgttct gtcccatttg ccatagtcct   7800
cacctatccc tgttgtattt tatcgggtcc aactcaacca tttaaggtat ttgccagctc   7860
ttgtatgcat ttaggttttg tttctttgtt ttttagctca tgaaattagg tacaaagtca   7920
gagaggggtc tggcatataa aacctcagca gaaataaaga ggttttgttg tttggtaaga   7980
acataccttg ggttggttgg gcacggtggc tcgtgcctgt aatcccaaca ctttgggagg   8040
ccaaggcagg ctgatcactt gaagttggga gttcaagacc agcctggcca acatggtgaa   8100
atcccgtctc tactgaaaat acaaaaatta accaggcatg gtggtgtgtg cctgtagtcc   8160
caggaatcac ttgaacccag gaggcggagg ttgcagtgag ctgagatctc accactgcac   8220
actgcactcc agcctgggca atggaatgag attccatccc aaaaaataaa aaaataaaaa   8280
aataaagaac ataccttggg ttgatccact taggaacctc agataataac atctgccacg   8340
tatagagcaa ttgctatgtc ccaggcactc tactagacac ttcatacagt ttagaaaatc   8400
agatgggtgt agatcaaggc aggagcagga accaaaaaga aaggcataaa cataagaaaa   8460
aaaatggaag gggtggaaac agagtacaat aacatgagta atttgatggg ggctattatg   8520
aactgagaaa tgaactttga aaagtatctt ggggccaaat catgtagact cttgagtgat   8580
gtgttaagga atgctatgag tgctgagagg gcatcagaag tccttgagag cctccagaga   8640
aaggctctta aaaatgcagc gcaatctcca gtgacagaag atactgctag aaatctgcta   8700
gaaaaaaaac aaaaaaggca tgtatagagg aattatgagg gaaagatacc aagtcacggt   8760
ttattcttca aaatggaggt ggcttgttgg gaaggtggaa gctcatttgg ccagagtgga   8820
aatggaattg ggagaaatcg atgaccaaat gtaaacactt ggtgcctgat atagcttgac   8880
accaagttag ccccaagtga aataccctgg caatattaat gtgtcttttc ccgatattcc   8940
tcaggtactc caaagattca ggtttactca cgtcatccag cagagaatgg aaagtcaaat   9000
ttcctgaatt gctatgtgtc tgggtttcat ccatccgaca ttgaagttga cttactgaag   9060
aatggagaga gaattgaaaa agtggagcat tcagacttgt ctttcagcaa ggactggtct   9120
ttctatctct tgtactacac tgaattcacc cccactgaaa aagatgagta tgcctgccgt   9180
gtgaaccatg tgactttgtc acagcccaag atagttaagt ggggtaagtc ttacattctt   9240
ttgtaagctg ctgaaagttg tgtatgagta gtcatatcat aaagctgctt tgatataaaa   9300
aaggtctatg gccatactac cctgaatgag tcccatccca tctgatataa acaatctgca   9360
tattgggatt gtcagggaat gttcttaaag atcagattag tggcacctgc tgagatactg   9420
atgcacagca tggtttctga accagtagtt tccctgcagt tgagcaggga gcagcagcag   9480
cacttgcaca aatacatata cactcttaac acttcttacc tactggcttc ctctagcttt   9540
tgtggcagct tcaggtatat ttagcactga acgaacatct caagaaggta taggcctttg   9600
tttgtaagtc ctgctgtcct agcatcctat aatcctggac ttctccagta ctttctggct   9660
ggattggtat ctgaggctag taggaagggc ttgttcctgc tgggtagctc taaacaatgt   9720
attcatgggt aggaacagca gcctattctg ccagccttat ttctaaccat tttagacatt   9780
tgttagtaca tggtatttta aaagtaaaac ttaatgtctt cctttttttt ctccactgtc   9840
tttttcatag atcgagacat gtaagcagca tcatggaggt aagtttttga ccttgagaaa   9900
atgtttttgt ttcactgtcc tgaggactat ttatagacag ctctaacatg ataaccctca   9960
ctatgtggag aacattgaca gagtaacatt ttagcaggga aagaagaatc ctacagggtc  10020
atgttccctt ctcctgtgga gtggcatgaa gaaggtgtat ggccccaggt atggccatat  10080
tactgaccct ctacagagag ggcaaaggaa ctgccagtat ggtattgcag gataaaggca  10140
ggtggttacc cacattacct gcaaggcttt gatctttctt ctgccatttc cacattggac  10200
atctctgctg aggagagaaa atgaaccact cttttccttt gtataatgtt gttttattct  10260
tcagacagaa gagaggagtt atacagctct gcagacatcc cattcctgta tggggactgt  10320
gtttgcctct tagaggttcc caggccacta gaggagataa agggaaacag attgttataa  10380
cttgatataa tgatactata atagatgtaa ctacaaggag ctccagaagc aagagagagg  10440
gaggaacttg gacttctctg catctttagt tggagtccaa aggcttttca atgaaattct  10500
actgcccagg gtacattgat gctgaaaccc cattcaaatc tcctgttata ttctagaaca  10560
gggaattgat ttgggagagc atcaggaagg tggatgatct gcccagtcac actgttagta  10620
aattgtagag ccaggacctg aactctaata tagtcatgtg ttacttaatg acggggacat  10680
gttctgagaa atgcttacac aaacctaggt gttgtagcct actacacgca taggctacat  10740
ggtatagcct attgctccta gactacaaac ctgtacagcc tgttactgta ctgaatactg  10800
tgggcagttg taacacaatg gtaagtattt gtgtatctaa acatagaagt tgcagtaaaa  10860
atatgctatt ttaatcttat gagaccactg tcatatatac agtccatcat tgaccaaaac  10920
atcatatcag cattttttct tctaagattt tgggagcacc aaagggatac actaacagga  10980
tatactcttt ataatgggtt tggagaactg tctgcagcta cttcttttaa aaaggtgatc  11040
tacacagtag aaattagaca agtttggtaa tgagatctgc aatccaaata aaataaattc  11100
attgctaacc tttttctttt cttttcaggt ttgaagatgc cgcatttgga ttggatgaat  11160
tccaaattct gcttgcttgc tttttaatat tgatatgctt atacacttac actttatgca  11220
caaaatgtag ggttataata atgttaacat ggacatgatc ttctttataa ttctactttg  11280
agtgctgtct ccatgtttga tgtatctgag caggttgctc cacaggtagc tctaggaggg  11340
ctggcaactt agaggtgggg agcagagaat tctcttatcc aacatcaaca tcttggtcag  11400
atttgaactc ttcaatctct tgcactcaaa gcttgttaag atagttaagc gtgcataagt  11460
taacttccaa tttacatact ctgcttagaa tttgggggaa aatttagaaa tataattgac  11520
aggattattg gaaatttgtt ataatgaatg aaacattttg tcatataaga ttcatattta  11580
cttcttatac atttgataaa gtaaggcatg gttgtggtta atctggttta tttttgttcc  11640
acaagttaaa taaatcataa aacttgatgt gttatctctt atatctcact cccactatta  11700
cccctttatt ttcaaacagg gaaacagtct tcaagttcca cttggtaaaa aatgtgaacc  11760
ccttgtatat agagtttggc tcacagtgta aagggcctca gtgattcaca ttttccagat  11820
taggaatctg atgctcaaag aagttaaatg gcatagttgg ggtgacacag ctgtctagtg  11880
ggaggccagc cttctatatt ttagccagcg ttctttcctg cgggccaggt catgaggagt  11940
atgcagactc taagagggag caaaagtatc tgaaggattt aatattttag caaggaatag  12000
atatacaatc atcccttggt ctccctgggg gattggtttc aggacccctt cttggacacc  12060
aaatctatgg atatttaagt cccttctata aaatggtata gtatttgcat ataacctatc  12120
cacatcctcc tgtatacttt aaatcatttc tagattactt gtaataccta atacaatgta  12180
aatgctatgc aaatagttgt tattgtttaa ggaataatga caagaaaaaa aagtctgtac  12240
atgctcagta aagacacaac catccctttt tttccccagt gtttttgatc catggtttgc  12300
tgaatccaca gatgtggagc ccctggatac ggaaggcccg ctgtactttg aatgacaaat  12360
aacagattta aaattttcaa ggcatagttt tatacctgat ggccagcttt gtttatttga  12420
ccaagaatct gagttagcta gttctaggta ctgacaggat aaataaaaca caacactgct  12480
cccgatcttc tcagtttagc agagggacag atatgcactc aaataattaa aatatatcct  12540
gataagaata tagcataggt acgcgcgaag aacttggcaa tcgaaatttt gttgttcagg  12600
ctgggcgagg tgtctcatgt ctgtaatccc agcactttgg gaggccatgg taggatgatc  12660
gcttgagccc aggagtccga gaccagcctg ggcaacataa caagaccctg tctcaattca  12720
aagaattgaa ttaaaaaaaa caaaaaataa tttttttaaa aaagaaatgt tgttgttcaa  12780
ggaacaacaa caaaaatcta gggaggtgtt agagaagcca tttgcctgag ctgagagtaa  12840
gttgctagtg gttctcttga ttggtaggtg gggcctgggt ttccaggcat ggtagccagg  12900
aaggacagcc acatggcagg tttgggtaat tccaaacagt ggaggaaggg tgtctggggg  12960
aagacttgta ggaactcagc tgaaaaaatt gggggatgat actctgaaag aaaaacaaag  13020
ttttaaaatt tctactctta cacttaacac ataatgcttc tgtgaccgga tatttagggg  13080
ttttcccccc acactctgtt aggagaaaaa ttttagacag attaaattta acagagttta  13140
actgagcaaa aatgattctc gaaccaggca gctgccggag ccagaatagg ttcaaaatga  13200
ctctgggggt gccacatggt tggatgacat ttagggacag aaaaaggaaa gtgatgtgca  13260
gaaaatggaa gtcaggggca gaagcagcca gattggttgc agttcagcat ttgcctcatt  13320
taaacagggt ttgaagagtt ggccacctgt gattggctga gactctgtgg tataagagta  13380
agttacagtc tgtttacaca tccagttagg ttacagttca ctatgcagag agaaatcttt  13440
agcctgaact tacacaggga ggcagtttta tttatttatt taattttttt tttttgagac  13500
aaggtctcac tctgtcaccc gggctggagt tcagtggtat gatcatggct tattgcagcc  13560
tcgacttcct ggcctcaagc aatccttccg cctcaggctc tagagtagct gggactacag  13620
gcacatgtca gcatgcctgg ctaattttgt tttttaattt ttagtagaga tgaactcctg  13680
gccttgcaca attctttcgc ctcagcctcc gaaaatgctg ggattacagg tgtgagccac  13740
tgtgcccagc taaggcaact ttaggctaaa cctttttttg agacagagtt tctctcttgt  13800
tgtctaggct ggagtgcagt tgcaccatct tggctcactg caacctccac ctccagggtt  13860
caagtgattc tcgttcctca gcctcccgag taactgggat tacaggcatg cgccaccacg  13920
cctggctaat tttgtgtttt tagtagagat ggtgtttcac catgttgtcc aggctggtct  13980
caaactcctg gcctcaagtg atcctctggc ctcagcttcc cagagtactg agattacagg  14040
catgagccac tgtgccctgc ctaggctaaa cttaatttaa caacaccaaa caatctccag  14100
cagacaccaa ctgggtatcc cataattcaa ttcgattttg attggatcta cctggagatg  14160
gtgtcagatc ccgctggttg agggttcagt cccacaagac tgccctccac ttcagatgcc  14220
aatcacacat tgtaggttgt tacctctact tctgactgac cagctggaaa ccagaactcc  14280
catgactgcc tccttgactt tggttaattt gctaggacag ttcatattta ccaatctatt  14340
ataaaagatt aaaggctaca gacgaataac tagatgaaaa gatgaatagg gctatatg    14398


<210>  49

<211>  2707
<212>  DNA
<213>  Homo sapiens

<220>
<223>  cs1 target region

<400>  49
gtaataccta agagggaagt ggcttcattt cagtggctga cttccagaga gcaatatggc     60
tggttcccca acatgcctca ccctcatcta tatcctttgg cagctcacag ggtcagcagc    120
ctctggaccc gtgaaagagc tggtcggttc cgttggtggg gccgtgactt tccccctgaa    180
gtccaaagta aagcaagttg actctattgt ctggaccttc aacacaaccc ctcttgtcac    240
catacagcca gaagggggca ctatcatagt gacccaaaat cgtaataggg agagagtaga    300
cttcccagat ggaggctact ccctgaagct cagcaaactg aagaagaatg actcagggat    360
ctactatgtg gggatataca gctcatcact ccagcagccc tccacccagg agtacgtgct    420
gcatgtctac gagcacctgt caaagcctaa agtcaccatg ggtctgcaga gcaataagaa    480
tggcacctgt gtgaccaatc tgacatgctg catggaacat ggggaagagg atgtgattta    540
tacctggaag gccctggggc aagcagccaa tgagtcccat aatgggtcca tcctccccat    600
ctcctggaga tggggagaaa gtgatatgac cttcatctgc gttgccagga accctgtcag    660
cagaaacttc tcaagcccca tccttgccag gaagctctgt gaaggtgctg ctgatgaccc    720
agattcctcc atggtcctcc tgtgtctcct gttggtgccc ctcctgctca gtctctttgt    780
actggggcta tttctttggt ttctgaagag agagagacaa gaagagtaca ttgaagagaa    840
gaagagagtg gacatttgtc gggaaactcc taacatatgc ccccattctg gagagaacac    900
agagtacgac acaatccctc acactaatag aacaatccta aaggaagatc cagcaaatac    960
ggtttactcc actgtggaaa taccgaaaaa gatggaaaat ccccactcac tgctcacgat   1020
gccagacaca ccaaggctat ttgcctatga gaatgttatc tagacagcag tgcactcccc   1080
taagtctctg ctcaaaaaaa aaacaattct cggcccaaag aaaacaatca gaagaattca   1140
ctgatttgac tagaaacatc aaggaagaat gaagaacgtt gacttttttc caggataaat   1200
tatctctgat gcttctttag atttaagagt tcataattcc atccactgct gagaaatctc   1260
ctcaaaccca gaaggtttaa tcacttcatc ccaaaaatgg gattgtgaat gtcagcaaac   1320
cataaaaaaa gtgcttagaa gtattcctat aaaaatgtaa atgcaaggtc acacatatta   1380
atgacagcct gttgtattaa tgatggctcc aggtcagtgt ctggagtttc attccatccc   1440
agggcttgga tgtcaggatt ataccaagag tcttgctacc aggagggcaa gaagaccaaa   1500
acagacagac aagtccagca gaagcagatg cacctgacaa aaatggatgt attaattggc   1560
tctataaact atgtgcccag cactatgctg agcttacact aattggtcag acatgctgtc   1620
tgccctcatg aaattggctc caaatgaatg aactactttc atgagcagtt gtagcaggcc   1680
tgaccacaga ttcccagagg gccaggtgtg gatccacagg acttgaaggt caaagttcac   1740
aaagatgaag aatcagggta gctgaccatg tttggcagat actataatgg agacacagaa   1800
gtgtgcatgg cccaaggaca aggacctcca gccaggcttc atttatgcac ttgtgctgca   1860
aaagaaaagt ctaggtttta aggctgtgcc agaacccatc ccaataaaga gaccgagtct   1920
gaagtcacat tgtaaatcta gtgtaggaga cttggagtca ggcagtgaga ctggtggggc   1980
acggggggca gtgggtactt gtaaaccttt aaagatggtt aattcattca atagatattt   2040
attaagaacc tatgcggccc ggcatggtgg ctcacacctg taatcccagc actttgggag   2100
gccaaggtgg gtgggtcatc tgaggtcagg agttcaagac cagcctggcc aacatggtga   2160
aaccccatct ctactaaaga tacaaaaatt tgctgagcgt ggtggtgtgc acctgtaatc   2220
ccagctactc gagaggccaa ggcatgagaa tcgcttgaac ctgggaggtg gaggttgcag   2280
tgagctgaga tggcaccact gcactccggc ctaggcaacg agagcaaaac tccaatacaa   2340
acaaacaaac aaacacctgt gctaggtcag tctggcacgt aagatgaaca tccctaccaa   2400
tacagagctc accatctctt atacttaagt gaaaaacatg gggaagggga aaggggaatg   2460
gctgcttttg atatgttccc tgacacatat cttgaatgga gacctcccta ccaagtgatg   2520
aaagtgttga aaaacttaat aacaaatgct tgttgggcaa gaatgggatt gaggattatc   2580
ttctctcaga aaggcattgt gaaggaattg agccagatct ctctccctac tgcaaaaccc   2640
tattgtagta aaaaagtctt ctttactatc ttaataaaac agatattgtg agattcacat   2700
acaaaaa                                                             2707


<210>  50

<211>  49
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRAC T01-target

<400>  50
ttgtcccaca gatatccaga accctgaccc tgccgtgtac cagctgaga                 49

<210>  51

<211>  47
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CD52 T01-target

<400>  51
ttagctgtgc tcgcgctact ctctctttct ggcctggagg ctatcca                   47


<210>  52

<211>  47
<212>  DNA
<213>  Homo sapiens

<220>
<223>  B2M T01-target

<400>  52
tatatccttt ggcagctcac aggtgagtcc ggccggattc tcttcca                   47


<210>  53

<211>  47
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CS1 T01-target

<400>  53
tatatccttt ggcagctcac aggtgagtcc ggccggattc tcttcca                   47

<210>  54

<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  GMCSF_Tal_1

<400>  54
tgtggctgca gagcctgctg ctcttgggca ctgtggcctg cagca                     45


<210>  55

<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  GMCSF_Tal_2

<400>  55
tcctgaacct gagtagagac actgctgctg agatggtaag tgaga                     45

