                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, 
       L'ALIMENTATION ET L'ENVIRONNEMENT
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       AIX-MARSEILLE UNIVERSITE
       ECOLE CENTRALE DE MARSEILLE
 
<120>  USE OF UV-ACTIVATED ENZYMES TO IMPLEMENT OXIDATION REACTIONS AND 
       THE CORRESPONDING PROCESSES

<130>  WOB 20 BH INR CROX   |   B51667

<150>  EP20186971.6
<151>  2020-07-21

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  506
<212>  PRT
<213>  Colletotrichum graminicola


<220>
<221>  misc_feature
<223>  Alcohol oxidase (AlcOx)

<400>  1

Met Pro Thr Leu Arg Ser Ala Leu Arg Asn Leu Pro Ala Ala Leu Leu 
1               5                   10                  15      


Ala Leu Ala Ala Ala Cys Glu Ala Gln Asn Val Gly Lys Trp Gly Pro 
            20                  25                  30          


Met Val Lys Phe Pro Val Val Pro Val Ala Val Ala Leu Val Pro Glu 
        35                  40                  45              


Thr Gly Asn Leu Leu Val Trp Ser Ser Gly Trp Pro Asn Arg Trp Thr 
    50                  55                  60                  


Thr Ala Gly Asn Gly Lys Thr Tyr Thr Ser Leu Tyr Asn Val Asn Thr 
65                  70                  75                  80  


Gly Asn Ile Ser Asp Ala Ile Val Gln Asn Thr Gln His Asp Met Phe 
                85                  90                  95      


Cys Pro Gly Thr Ser Leu Asp Ala Asp Gly Arg Ile Ile Val Thr Gly 
            100                 105                 110         


Gly Ser Ser Ala Ala Lys Thr Ser Val Leu Asp Phe Lys Lys Gly Glu 
        115                 120                 125             


Ser Ser Pro Trp Thr Pro Leu Ser Asn Met Gln Ile Ser Arg Gly Tyr 
    130                 135                 140                 


Gln Ser Ser Cys Thr Thr Ser Glu Gly Lys Ile Phe Val Ile Gly Gly 
145                 150                 155                 160 


Ser Phe Ser Gly Ala Gly Thr Arg Asn Gly Glu Val Tyr Asp Pro Lys 
                165                 170                 175     


Ala Asn Thr Trp Thr Lys Leu Ala Gly Cys Pro Val Lys Pro Leu Val 
            180                 185                 190         


Met Gln Arg Gly Met Phe Pro Asp Ser His Ala Trp Leu Trp Ser Trp 
        195                 200                 205             


Lys Asn Gly Ser Val Leu Gln Ala Gly Pro Ser Lys Lys Met Asn Trp 
    210                 215                 220                 


Tyr Asp Thr Lys Gly Thr Gly Ser Asn Thr Pro Ala Gly Leu Arg Gly 
225                 230                 235                 240 


Thr Asp Glu Asp Ser Met Cys Gly Val Ser Val Met Tyr Asp Ala Val 
                245                 250                 255     


Ala Gly Lys Ile Phe Thr Tyr Gly Gly Gly Lys Gly Tyr Thr Gly Tyr 
            260                 265                 270         


Asp Ser Thr Ser Asn Ala His Ile Leu Thr Leu Gly Glu Pro Gly Gln 
        275                 280                 285             


Ala Val Gln Val Gln Lys Leu Ala Asn Gly Lys Tyr Asn Arg Gly Phe 
    290                 295                 300                 


Ala Asn Ala Val Val Met Pro Asp Gly Lys Ile Trp Val Val Gly Gly 
305                 310                 315                 320 


Met Gln Lys Met Trp Leu Phe Ser Asp Thr Thr Pro Gln Leu Thr Pro 
                325                 330                 335     


Glu Leu Phe Asp Pro Ala Thr Gly Ser Phe Thr Pro Thr Thr Pro His 
            340                 345                 350         


Thr Val Pro Arg Asn Tyr His Ser Thr Ala Leu Leu Met Ala Asp Ala 
        355                 360                 365             


Thr Ile Trp Ser Gly Gly Gly Gly Leu Cys Gly Ala Asn Cys Lys Glu 
    370                 375                 380                 


Asn His Phe Asp Gly Gln Phe Trp Ser Pro Pro Tyr Leu Phe Glu Ala 
385                 390                 395                 400 


Asp Gly Val Thr Pro Ala Lys Arg Pro Val Ile Gln Ser Leu Ser Asp 
                405                 410                 415     


Thr Ala Val Arg Ala Gly Ala Pro Ile Thr Ile Thr Met Gln Asp Ala 
            420                 425                 430         


Gly Ala Tyr Thr Phe Ser Met Ile Arg Val Ser Ala Thr Thr His Thr 
        435                 440                 445             


Val Asn Thr Asp Gln Arg Arg Ile Pro Leu Asp Gly Gln Asp Gly Gly 
    450                 455                 460                 


Asp Gly Lys Ser Phe Thr Val Asn Val Pro Asn Asp Tyr Gly Val Ala 
465                 470                 475                 480 


Ile Pro Gly Tyr Tyr Met Leu Phe Ala Met Asn Glu Ala Gly Val Pro 
                485                 490                 495     


Cys Val Ala Gln Phe Phe Lys Val Thr Leu 
            500                 505     


<210>  2
<211>  680
<212>  PRT
<213>  Fusarium graminearum


<220>
<221>  misc_feature
<223>  Galactose oxidase (GalOx)

<400>  2

Met Lys His Leu Leu Thr Leu Ala Leu Cys Phe Ser Ser Ile Asn Ala 
1               5                   10                  15      


Val Ala Val Thr Val Pro His Lys Ala Val Gly Thr Gly Ile Pro Glu 
            20                  25                  30          


Gly Ser Leu Gln Phe Leu Ser Leu Arg Ala Ser Ala Pro Ile Gly Ser 
        35                  40                  45              


Ala Ile Ser Arg Asn Asn Trp Ala Val Thr Cys Asp Ser Ala Gln Ser 
    50                  55                  60                  


Gly Asn Glu Cys Asn Lys Ala Ile Asp Gly Asn Lys Asp Thr Phe Trp 
65                  70                  75                  80  


His Thr Phe Tyr Gly Ala Asn Gly Asp Pro Lys Pro Pro His Thr Tyr 
                85                  90                  95      


Thr Ile Asp Met Lys Thr Thr Gln Asn Val Asn Gly Leu Ser Met Leu 
            100                 105                 110         


Pro Arg Gln Asp Gly Asn Gln Asn Gly Trp Ile Gly Arg His Glu Val 
        115                 120                 125             


Tyr Leu Ser Ser Asp Gly Thr Asn Trp Gly Ser Pro Val Ala Ser Gly 
    130                 135                 140                 


Ser Trp Phe Ala Asp Ser Thr Thr Lys Tyr Ser Asn Phe Glu Thr Arg 
145                 150                 155                 160 


Pro Ala Arg Tyr Val Arg Leu Val Ala Ile Thr Glu Ala Asn Gly Gln 
                165                 170                 175     


Pro Trp Thr Ser Ile Ala Glu Ile Asn Val Phe Gln Ala Ser Ser Tyr 
            180                 185                 190         


Thr Ala Pro Gln Pro Gly Leu Gly Arg Trp Gly Pro Thr Ile Asp Leu 
        195                 200                 205             


Pro Ile Val Pro Ala Ala Ala Ala Ile Glu Pro Thr Ser Gly Arg Val 
    210                 215                 220                 


Leu Met Trp Ser Ser Tyr Arg Asn Asp Ala Phe Gly Gly Ser Pro Gly 
225                 230                 235                 240 


Gly Ile Thr Leu Thr Ser Ser Trp Asp Pro Ser Thr Gly Ile Val Ser 
                245                 250                 255     


Asp Arg Thr Val Thr Val Thr Lys His Asp Met Phe Cys Pro Gly Ile 
            260                 265                 270         


Ser Met Asp Gly Asn Gly Gln Ile Val Val Thr Gly Gly Asn Asp Ala 
        275                 280                 285             


Lys Lys Thr Ser Leu Tyr Asp Ser Ser Ser Asp Ser Trp Ile Pro Gly 
    290                 295                 300                 


Pro Asp Met Gln Val Ala Arg Gly Tyr Gln Ser Ser Ala Thr Met Ser 
305                 310                 315                 320 


Asp Gly Arg Val Phe Thr Ile Gly Gly Ser Trp Ser Gly Gly Val Phe 
                325                 330                 335     


Glu Lys Asn Gly Glu Val Tyr Ser Pro Ser Ser Lys Thr Trp Thr Ser 
            340                 345                 350         


Leu Pro Asn Ala Lys Val Asn Pro Met Leu Thr Ala Asp Lys Gln Gly 
        355                 360                 365             


Leu Tyr Arg Ser Asp Asn His Ala Trp Leu Phe Gly Trp Lys Lys Gly 
    370                 375                 380                 


Ser Val Phe Gln Ala Gly Pro Ser Thr Ala Met Asn Trp Tyr Tyr Thr 
385                 390                 395                 400 


Ser Gly Ser Gly Asp Val Lys Ser Ala Gly Lys Arg Gln Ser Asn Arg 
                405                 410                 415     


Gly Val Ala Pro Asp Ala Met Cys Gly Asn Ala Val Met Tyr Asp Ala 
            420                 425                 430         


Val Lys Gly Lys Ile Leu Thr Phe Gly Gly Ser Pro Asp Tyr Gln Asp 
        435                 440                 445             


Ser Asp Ala Thr Thr Asn Ala His Ile Ile Thr Leu Gly Glu Pro Gly 
    450                 455                 460                 


Thr Ser Pro Asn Thr Val Phe Ala Ser Asn Gly Leu Tyr Phe Ala Arg 
465                 470                 475                 480 


Thr Phe His Thr Ser Val Val Leu Pro Asp Gly Ser Thr Phe Ile Thr 
                485                 490                 495     


Gly Gly Gln Arg Arg Gly Ile Pro Phe Glu Asp Ser Thr Pro Val Phe 
            500                 505                 510         


Thr Pro Glu Ile Tyr Val Pro Glu Gln Asp Thr Phe Tyr Lys Gln Asn 
        515                 520                 525             


Pro Asn Ser Ile Val Arg Val Tyr His Ser Ile Ser Leu Leu Leu Pro 
    530                 535                 540                 


Asp Gly Arg Val Phe Asn Gly Gly Gly Gly Leu Cys Gly Asp Cys Thr 
545                 550                 555                 560 


Thr Asn His Phe Asp Ala Gln Ile Phe Thr Pro Asn Tyr Leu Tyr Asn 
                565                 570                 575     


Ser Asn Gly Asn Leu Ala Thr Arg Pro Lys Ile Thr Arg Thr Ser Thr 
            580                 585                 590         


Gln Ser Val Lys Val Gly Gly Arg Ile Thr Ile Ser Thr Asp Ser Ser 
        595                 600                 605             


Ile Ser Lys Ala Ser Leu Ile Arg Tyr Gly Thr Ala Thr His Thr Val 
    610                 615                 620                 


Asn Thr Asp Gln Arg Arg Ile Pro Leu Thr Leu Thr Asn Asn Gly Gly 
625                 630                 635                 640 


Asn Ser Tyr Ser Phe Gln Val Pro Ser Asp Ser Gly Val Ala Leu Pro 
                645                 650                 655     


Gly Tyr Trp Met Leu Phe Val Met Asn Ser Ala Gly Val Pro Ser Val 
            660                 665                 670         


Ala Ser Thr Ile Arg Val Thr Gln 
        675                 680 


<210>  3
<211>  711
<212>  PRT
<213>  Colletotrichum graminicola


<220>
<221>  misc_feature
<223>  Aryl alcohol oxidase (AAO)

<400>  3

Met Val Arg Ser Cys Ala Tyr Lys Ala Ile Ala Ala Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Ala Ser Ala Ala Ile Thr Ser Cys Pro Asn Asn Glu Thr 
            20                  25                  30          


Val Trp Glu Thr Pro Ile Gly Val Lys Tyr Thr Leu Cys Pro Gly Ser 
        35                  40                  45              


Asp Tyr Gln Asn Gly Gly Ala Ser Leu Gln Thr Val Arg Asp Ile Gln 
    50                  55                  60                  


Ser Ser Leu Glu Cys Ala Lys Ile Cys Asp Ser Asp Ala Arg Cys Asn 
65                  70                  75                  80  


Arg Ala Val Tyr Asp Asn Val Asn Lys Ala Cys Asp Val Lys Asn Ser 
                85                  90                  95      


Thr Asn Pro Met Gln Trp Ala Ala Asp Asp Arg Phe Glu Thr Ile Arg 
            100                 105                 110         


Leu Thr Asn Asp Leu Pro Glu Gly Ala Phe Ile Ser Thr Cys Ser Phe 
        115                 120                 125             


Asn Glu Thr Ser Tyr Arg Val Pro Glu Thr Asn Ala Glu Tyr Arg Ile 
    130                 135                 140                 


Cys Pro Asp Thr Asp Tyr Thr Gly Val Asn Ala Lys Val Val Glu Gly 
145                 150                 155                 160 


Val Thr Thr Ile Gln Ala Cys Ala Glu Leu Cys Ser Asn Thr Gln Asp 
                165                 170                 175     


Cys Arg Lys Ser Val Phe Asp His Ile Asn Asn Ala Cys Ala Ile Lys 
            180                 185                 190         


Ala Ala Glu Pro Ala Thr Ser Ile Phe Trp Val Gln Asp Lys Gln Phe 
        195                 200                 205             


Ser Thr Ile Arg Leu Pro Glu Asn Ile Asp Pro Ala Val Lys Gly Lys 
    210                 215                 220                 


Trp Gly Asp Leu Ile Arg Leu Pro Val Ile Pro Val Ala Ala Tyr Ile 
225                 230                 235                 240 


Val Pro Ser Tyr Pro Glu Pro Ser Arg Leu Leu Phe Phe Ser Ser Trp 
                245                 250                 255     


Ser Asn Asp Ala Phe Ser Gly Ala Ser Gly Met Thr Gln Phe Gly Asp 
            260                 265                 270         


Tyr Asp Phe Ala Thr Gly Ala Ile Ser Gln Arg Thr Val Thr Asn Thr 
        275                 280                 285             


His His Asp Met Phe Cys Pro Gly Ile Ser Gln Leu Glu Asp Gly Arg 
    290                 295                 300                 


Ile Leu Ile Gln Gly Gly Ser Asp Ala Asp Thr Val Ser Ile Tyr Asp 
305                 310                 315                 320 


Pro Ala Thr Asn Glu Phe Thr Arg Gly Pro Asn Met Thr Leu Ala Arg 
                325                 330                 335     


Gly Tyr Gln Thr Ser Cys Thr Leu Ser Asn Gly Lys Val Phe Thr Ile 
            340                 345                 350         


Gly Gly Ala Tyr Ser Gly Glu Arg Val Gly Lys Asn Gly Glu Val Tyr 
        355                 360                 365             


Asp Pro Val Ala Asn Ala Trp Thr Tyr Leu Pro Gly Ala Asp Phe Arg 
    370                 375                 380                 


Pro Met Leu Thr Asn Asp His Glu Gly Ile Trp Arg Glu Asp Asn His 
385                 390                 395                 400 


Ala Trp Leu Phe Gly Trp Lys Asn Gly Ser Ile Phe Gln Ala Gly Pro 
                405                 410                 415     


Ser Lys Asp Gln His Trp Tyr Gly Ile Gln Gly Asn Gly Thr Val Ala 
            420                 425                 430         


Lys Ala Ala Thr Arg Asp Asp Asp Asp Ala Met Cys Gly Val Trp Val 
        435                 440                 445             


Met Tyr Asp Ala Val Ala Gly Lys Ile Phe Ser Ala Gly Gly Ser Pro 
    450                 455                 460                 


Asp Tyr Thr Asp Ser Pro Ala Thr Gln Arg Ala His Ile Thr Thr Ile 
465                 470                 475                 480 


Gly Glu Pro Asn Thr Pro Ala Glu Val Glu Arg Val Ala Asp Met Gly 
                485                 490                 495     


Phe Pro Arg Gly Phe Ala Asn Ala Val Val Leu Pro Asp Gly Gln Val 
            500                 505                 510         


Leu Val Thr Gly Gly Gln Arg Met Ser Leu Val Phe Thr Asn Thr Asp 
        515                 520                 525             


Gly Ile Leu Val Ala Glu Leu Phe Asn Pro Glu Thr Arg Glu Trp Lys 
    530                 535                 540                 


Gln Met Ala Pro Met Ala Val Pro Arg Asn Tyr His Ser Val Ser Ile 
545                 550                 555                 560 


Leu Leu Pro Asp Ala Thr Val Phe Ser Gly Gly Gly Gly Met Cys Trp 
                565                 570                 575     


Val Gln Asn Val Gly Asp Ser Thr Ala Gly Cys Asp Lys Thr Val Asp 
            580                 585                 590         


His Ser Asp Gly Glu Ile Phe Glu Pro Pro Tyr Leu Phe Asn Glu Asp 
        595                 600                 605             


Gly Ser Arg Ala Ala Arg Pro Val Ile Ser Ala Ile Ser Ala Asp Pro 
    610                 615                 620                 


Ile Lys Ala Gly Ala Thr Leu Thr Phe Thr Val Glu Gly Val Glu Gly 
625                 630                 635                 640 


Gln Gly Thr Ala Ala Leu Ile Arg Leu Gly Ser Val Thr His Ser Val 
                645                 650                 655     


Asn Ser Asp Gln Arg Arg Val Pro Leu Asn Val Thr Val Ser Gly Asn 
            660                 665                 670         


Glu Tyr Ser Ala Thr Leu Pro Asp Asp Tyr Gly Ile Leu Leu Pro Gly 
        675                 680                 685             


Tyr Tyr Tyr Leu Phe Val Ser Thr Pro Gln Gly Thr Pro Ser Ile Ala 
    690                 695                 700                 


Lys Thr Val His Val Ile Leu 
705                 710     


<210>  4
<211>  559
<212>  PRT
<213>  Pycnoporus cinnabarinus


<220>
<221>  misc_feature
<223>  Glyoxal oxidase (GLOx)

<400>  4

Met Phe Gln Thr Thr Leu His Leu Leu Phe Val Leu Val Val Thr Gly 
1               5                   10                  15      


Arg Gly Leu Ala Ala Pro Ser Thr Pro Thr Gly Trp Gln Phe Asn Leu 
            20                  25                  30          


Lys Ala Glu Arg Ser Gly Ile Val Ala Leu Glu Ser Ile Val Val Ser 
        35                  40                  45              


Pro Thr Leu Val Val Phe Phe Asp Arg Ala Thr Asn Asp Pro Leu Gln 
    50                  55                  60                  


Ile Asn Asn His Ser Ala Trp Gly Ala Leu Trp Asn Leu Glu Thr Ser 
65                  70                  75                  80  


Thr Val Arg Ala Leu Asp Val Leu Thr Asn Ser Phe Cys Ala Ser Gly 
                85                  90                  95      


Ala Leu Leu Ser Asn Gly Thr Met Ala Ser Ile Gly Gly Asp Pro Asn 
            100                 105                 110         


Gly Phe Pro Gly Asn Pro Ala Ile His Pro Gly Thr Gln Ala Ile Arg 
        115                 120                 125             


Leu Phe Glu Pro Cys Asp Ser Pro Thr Gly Glu Gly Cys Thr Leu Phe 
    130                 135                 140                 


Glu Asp Pro Val Thr Leu His Leu Leu Glu Lys Arg Trp Tyr Pro Ser 
145                 150                 155                 160 


Ser Val Arg Ile Phe Asp Gly Ser Leu Leu Ile Val Gly Gly Met His 
                165                 170                 175     


Glu Glu Thr Pro Phe Tyr Asn Thr Asp Pro Ala Leu Ser Phe Glu Phe 
            180                 185                 190         


Phe Pro Pro Lys Glu Ser Thr Pro Arg Pro Ser Glu Phe Leu Asn Arg 
        195                 200                 205             


Ser Leu Pro Ala Asn Leu Phe Pro Arg Val Phe Ala Leu Pro Asp Gly 
    210                 215                 220                 


Lys Val Phe Met Val Ala Asn Asn Gln Ser Ile Ile Tyr Asp Ile Glu 
225                 230                 235                 240 


Ala Asn Thr Glu Arg Ile Leu Pro Asp Ile Pro Asn Asn Val Arg Val 
                245                 250                 255     


Thr Asn Pro Ile Asp Gly Ser Ala Ile Leu Leu Pro Leu Ser Pro Pro 
            260                 265                 270         


Asp Phe Val Pro Glu Val Leu Val Cys Gly Gly Thr Gln Thr Asp Thr 
        275                 280                 285             


Ile Asp Pro Ser Leu Leu Thr Ser Gln Thr Pro Ala Ser Ser Gln Cys 
    290                 295                 300                 


Ser Arg Ile Arg Leu Asp Glu Glu Gly Ile Ala Arg Gly Trp Glu Val 
305                 310                 315                 320 


Glu His Met Leu Glu Gly Arg Met Met Pro Glu Leu Val His Leu Pro 
                325                 330                 335     


Asn Gly Gln Val Leu Ile Ala Asn Gly Ala Arg Thr Gly Phe Ala Ala 
            340                 345                 350         


Ile Ala Ser Val Ser Asp Pro Val Gly Gly Ser Asn Ala Asp His Ala 
        355                 360                 365             


Val Leu Val Pro Ser Leu Tyr Thr Pro Asp Ala Pro Leu Gly Thr Arg 
    370                 375                 380                 


Ile Ser Asn Val Gly Leu Pro Ser Ser Gly Ile Ala Arg Val Tyr His 
385                 390                 395                 400 


Ser Ser Ile Thr Leu Thr Pro Gln Gly Asn Phe Leu Ile Ala Gly Ser 
                405                 410                 415     


Asn Pro Asn Asn Asn Ser Ser Val Thr Ala Gly Val Lys Phe Pro Ser 
            420                 425                 430         


Glu Phe Arg Val Gln Thr Leu Asp Pro Pro Phe Met Phe Val Glu Arg 
        435                 440                 445             


Pro Lys Ile Leu Ser Met Pro Lys Lys Leu Ala Phe Gly Lys Ser Phe 
    450                 455                 460                 


Thr Val Pro Ile Ala Val Pro Ser Thr Leu Ala His Pro Gly Ala Lys 
465                 470                 475                 480 


Val Gln Val Ser Leu Met Asp Leu Gly Phe Ser Ser His Ala Phe His 
                485                 490                 495     


Ser Ser Ala Arg Leu Val Phe Met Asn Ala Lys Ile Ser Gln Asp Gly 
            500                 505                 510         


Lys Ser Leu Thr Phe Thr Thr Pro Pro Asn Gly Arg Val Tyr Pro Pro 
        515                 520                 525             


Gly Pro Ala Thr Ile Phe Leu Thr Ile Asp Asp Val Thr Ser Glu Gly 
    530                 535                 540                 


Ala Trp Val Met Met Gly Ser Gly Asn Pro Pro Pro Thr Leu Glu 
545                 550                 555                 


<210>  5
<211>  644
<212>  PRT
<213>  Streptomyces lividans


<220>
<221>  misc_feature
<223>  GlxA-type enzyme

<400>  5

Met Lys Asp Arg Ala Gly Arg Arg Arg Ala Arg Arg Phe Ala Ile Gly 
1               5                   10                  15      


Thr Ala Val Val Val Ala Leu Ala Gly Met Asn Gly Pro Trp Leu Tyr 
            20                  25                  30          


Arg Phe Ser Thr Glu Lys Tyr His Gln Tyr Lys Ile Asn Gln Pro Glu 
        35                  40                  45              


Tyr Lys Ala Ala Asn Gly Lys Trp Glu Ile Ile Glu Phe Pro Glu Lys 
    50                  55                  60                  


Tyr Arg Gln Asn Thr Ile His Ala Ala Leu Leu Arg Thr Gly Lys Val 
65                  70                  75                  80  


Leu Met Val Ala Gly Ser Gly Asn Asn Gln Asp Asn Ser Asp Asp Lys 
                85                  90                  95      


Gln Tyr Asp Thr Arg Ile Trp Asp Pro Val Lys Gly Thr Ile Lys Lys 
            100                 105                 110         


Val Pro Thr Pro Ser Asp Leu Phe Cys Thr Gly His Thr Gln Leu Ala 
        115                 120                 125             


Asn Gly Asn Leu Leu Ile Ala Gly Gly Thr Lys Arg Tyr Glu Lys Leu 
    130                 135                 140                 


Lys Gly Asp Val Thr Lys Ala Gly Gly Leu Met Val Val His Asn Glu 
145                 150                 155                 160 


Asn Pro Asp Lys Pro Ile Thr Leu Pro Ala Gly Thr Lys Phe Thr Gly 
                165                 170                 175     


Lys Glu Asn Gly Lys Thr Phe Val Ser Lys Asp Pro Val Leu Val Pro 
            180                 185                 190         


Arg Ala Glu Lys Val Phe Asp Pro Ala Thr Gly Ala Phe Val Arg Asn 
        195                 200                 205             


Asp Pro Gly Leu Gly Arg Ile Tyr Val Glu Ala Gln Lys Ser Gly Ser 
    210                 215                 220                 


Ala Tyr Glu Thr Gly Thr Glu Asp Asn Tyr Arg Val Gln Gly Leu Ser 
225                 230                 235                 240 


Gly Ala Asp Ala Arg Asn Thr Tyr Gly Ile Ala Gln Lys Leu Ala Leu 
                245                 250                 255     


Asp Lys Lys Asp Phe Gln Gly Ile Arg Asp Ala Phe Glu Phe Asp Pro 
            260                 265                 270         


Val Ala Glu Lys Tyr Ile Lys Val Asp Pro Met His Glu Ala Arg Trp 
        275                 280                 285             


Tyr Pro Thr Leu Thr Thr Leu Gly Asp Gly Lys Leu Ser Val Ser Gly 
    290                 295                 300                 


Leu Asp Asp Ile Gly Gln Leu Val Pro Gly Lys Asn Glu Val Tyr Asp 
305                 310                 315                 320 


Pro Lys Thr Lys Ala Trp Thr Tyr Thr Asp Lys Val Arg Gln Phe Pro 
                325                 330                 335     


Thr Tyr Pro Ala Leu Phe Leu Met Gln Asn Gly Lys Ile Phe Tyr Ser 
            340                 345                 350         


Gly Ala Asn Ala Gly Tyr Gly Pro Asp Asp Val Gly Arg Thr Pro Gly 
        355                 360                 365             


Val Trp Asp Val Glu Thr Asn Lys Phe Thr Lys Val Pro Gly Met Ser 
    370                 375                 380                 


Asp Ala Asn Met Leu Glu Thr Ala Asn Thr Val Leu Leu Pro Pro Ala 
385                 390                 395                 400 


Gln Asp Glu Lys Tyr Met Val Ile Gly Gly Gly Gly Val Gly Glu Ser 
                405                 410                 415     


Lys Leu Ser Ser Glu Lys Thr Arg Ile Ala Asp Leu Lys Ala Asp Asp 
            420                 425                 430         


Pro Lys Phe Val Asp Gly Pro Ser Leu Glu Lys Gly Thr Arg Tyr Pro 
        435                 440                 445             


Gln Ala Ser Ile Leu Pro Asp Asp Ser Val Leu Val Ser Gly Gly Ser 
    450                 455                 460                 


Gln Asp Tyr Arg Gly Arg Gly Asp Ser Asn Ile Leu Gln Ala Arg Leu 
465                 470                 475                 480 


Tyr His Pro Asp Thr Asn Glu Phe Glu Arg Val Ala Asp Pro Leu Val 
                485                 490                 495     


Gly Arg Asn Tyr His Ser Gly Ser Ile Leu Leu Pro Asp Gly Arg Leu 
            500                 505                 510         


Met Phe Phe Gly Ser Asp Ser Leu Tyr Ala Asp Lys Ala Asn Thr Lys 
        515                 520                 525             


Pro Gly Lys Phe Glu Gln Arg Ile Glu Ile Tyr Thr Pro Pro Tyr Leu 
    530                 535                 540                 


Tyr Arg Asp Ser Arg Pro Asp Leu Ser Gly Gly Pro Gln Thr Ile Ala 
545                 550                 555                 560 


Arg Gly Gly Ser Gly Thr Phe Thr Ser Arg Ala Ala Ser Thr Val Lys 
                565                 570                 575     


Lys Val Arg Leu Ile Arg Pro Ser Ala Ser Thr His Val Thr Asp Val 
            580                 585                 590         


Asp Gln Arg Ser Ile Ala Leu Asp Phe Lys Ala Asp Gly Asp Lys Leu 
        595                 600                 605             


Thr Val Thr Val Pro Ser Gly Lys Asn Leu Val Gln Ser Gly Trp Tyr 
    610                 615                 620                 


Met Met Phe Val Thr Asp Gly Glu Gly Thr Pro Ser Lys Ala Glu Trp 
625                 630                 635                 640 


Val Arg Val Pro 
                


