                         SEQUENCE LISTING

<110>  Waddington, Simon Nicholas
       Karda, Rajvinder
       Herzog, Christopher Dean
       Ng, Joanne
       Sacramento, Chester
       Schorge, Stephanie
       Ricks, David       
 
<120>  GENE THERAPY VECTOR FOR eEF1A2 AND USES THEREOF

<130>  ROPA-019/00US 329592-2103

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Thr Lys Tyr Tyr Ile Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Ala Tyr Ser Glu Lys Arg Tyr Asp Glu Ile Val Lys Glu Val Ser Ala 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Ala Thr Val Pro Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp His Gly Asp Asn Met Leu Glu Pro Ser Pro Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Glu Arg Lys Glu Gly Asn Ala Ser 
    210                 215                 220                 


Gly Val Ser Leu Leu Glu Ala Leu Asp Thr Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Ile Leu 
            260                 265                 270         


Arg Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Ile Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Ile 
305                 310                 315                 320 


Arg Arg Gly Asn Val Cys Gly Asp Ser Lys Ser Asp Pro Pro Gln Glu 
                325                 330                 335     


Ala Ala Gln Phe Thr Ser Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ser Pro Val Ile Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Asn Pro Lys Ser Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Glu Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Gln Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Asn Val Glu Lys Lys Ser Gly Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Gly Lys 
    450                 455                 460             


<210>  2
<211>  1389
<212>  DNA
<213>  Homo sapiens

<400>  2
atgggcaagg agaagaccca catcaacatc gtggtcatcg gccacgtgga ctccggaaag       60

tccaccacca cgggccacct catctacaaa tgcggaggta ttgacaaaag gaccattgag      120

aagttcgaga aggaggcggc tgagatgggg aagggatcct tcaagtatgc ctgggtgctg      180

gacaagctga aggcggagcg tgagcgcggc atcaccatcg acatctccct ctggaagttc      240

gagaccacca agtactacat caccatcatc gatgcccccg gccaccgcga cttcatcaag      300

aacatgatca cgggtacatc ccaggcggac tgcgcagtgc tgatcgtggc ggcgggcgtg      360

ggcgagttcg aggcgggcat ctccaagaat gggcagacgc gggagcatgc cctgctggcc      420

tacacgctgg gtgtgaagca gctcatcgtg ggcgtgaaca aaatggactc cacagagccg      480

gcctacagcg agaagcgcta cgacgagatc gtcaaggaag tcagcgccta catcaagaag      540

atcggctaca acccggccac cgtgcccttt gtgcccatct ccggctggca cggtgacaac      600

atgctggagc cctcccccaa catgccgtgg ttcaagggct ggaaggtgga gcgtaaggag      660

ggcaacgcaa gcggcgtgtc cctgctggag gccctggaca ccatcctgcc ccccacgcgc      720

cccacggaca agcccctgcg cctgccgctg caggacgtgt acaagattgg cggcattggc      780

acggtgcccg tgggccgggt ggagaccggc atcctgcggc cgggcatggt ggtgaccttt      840

gcgccagtga acatcaccac tgaggtgaag tcagtggaga tgcaccacga ggctctgagc      900

gaagctctgc ccggcgacaa cgtcggcttc aatgtgaaga acgtgtcggt gaaggacatc      960

cggcggggca acgtgtgtgg ggacagcaag tctgacccgc cgcaggaggc tgctcagttc     1020

acctcccagg tcatcatcct gaaccacccg gggcagatta gcgccggcta ctccccggtc     1080

atcgactgcc acacagccca catcgcctgc aagtttgcgg agctgaagga gaagattgac     1140

cggcgctctg gcaagaagct ggaggacaac cccaagtccc tgaagtctgg agacgcggcc     1200

atcgtggaga tggtgccggg aaagcccatg tgtgtggaga gcttctccca gtacccgcct     1260

ctcggccgct tcgccgtgcg cgacatgagg cagacggtgg ccgtaggcgt catcaagaac     1320

gtggagaaga agagcggcgg cgccggcaag gtcaccaagt cggcgcagaa ggcgcagaag     1380

gcgggcaag                                                             1389


<210>  3
<211>  448
<212>  DNA
<213>  Homo sapiens

<400>  3
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  4
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized eEF1A2 polynucleotide variant

<400>  4
atgggtaaag aaaaaacaca tattaatata gtagtaatcg gtcatgttga ctctggaaaa       60

tctactacta caggacattt gatttataaa tgtggaggaa ttgataaaag aacaatagaa      120

aaatttgaaa aagaagctgc tgaaatgggt aaaggtagtt ttaaatatgc ttgggttttg      180

gataaattga aagctgaaag agaaagagga attacaattg atatttcttt gtggaaattt      240

gaaactacaa aatattatat aacaataata gatgctcctg gacatagaga ttttattaaa      300

aatatgatta caggaacttc tcaagcagat tgtgctgttt tgatagtagc agcaggagtt      360

ggtgaattcg aagcaggcat ttctaaaaat ggacaaacta gagaacatgc tttgttggct      420

tatacattgg gcgtaaaaca attgattgta ggagttaata aaatggattc tactgaacct      480

gcatattctg aaaaaagata tgatgaaata gtaaaagaag tttctgctta tattaaaaaa      540

attggttata atcctgctac agttccattt gttcctattt ctggatggca tggagataat      600

atgttggaac ctagtcctaa tatgccttgg tttaaaggat ggaaagttga aaggaaagaa      660

ggaaatgcat caggagtctc cttgttggaa gctttggata caatcttgcc tccaacaaga      720

cctacagata aacctttgag attgcctctt caagatgtat ataaaatagg aggaatagga      780

acagtgccag ttggaagagt agaaacaggt atattgagac ctggaatggt tgtaacattt      840

gcaccagtta atataactac tgaagtaaaa tctgttgaaa tgcatcatga agctttgtct      900

gaagctcttc ctggagataa tgtaggattt aatgttaaaa atgtaagtgt aaaagatata      960

agaagaggaa atgtatgtgg tgatagtaaa tcagatccac ctcaagaagc agctcaattt     1020

acatcacaag taataatatt gaatcatcct ggacaaattt ctgcaggata ttcaccagta     1080

atagattgtc atacagcaca tatagcttgt aaatttgctg aattgaaaga aaaaattgat     1140

agaagaagtg gaaaaaaact tgaagataat cctaaatcat tgaaatcagg agatgcagct     1200

attgtagaaa tggtacctgg aaaaccaatg tgtgtagaat ctttttctca atatccacct     1260

ctcggaagat ttgctgttag agatatgaga caaacagttg cagtaggagt tattaaaaat     1320

gtagaaaaaa aaagcggagg tgcaggaaag gttacaaaat ccgcacaaaa agctcaaaaa     1380

gctggtaaat aa                                                         1392


<210>  5
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized eEF1A2 polynucleotide variant

<400>  5
atgggcaaag aaaaaacaca tataaacatt gtcgttatcg gacacgttga ttctggtaaa       60

agtacaacaa ccggtcactt gatatacaaa tgcgggggta tagacaaacg cactattgaa      120

aagttcgaga aagaagctgc ggagatgggc aaaggctcat tcaagtacgc gtgggtactc      180

gataagttga aagctgaacg cgagagggga atcaccatag acatctcact ttggaaattc      240

gagacaacca agtattacat aactattata gatgccccag gccacaggga tttcattaaa      300

aatatgataa ccggcacatc tcaagccgat tgcgccgtac tcatcgtcgc cgctggtgtg      360

ggtgagttcg aggcaggtat ttctaaaaat ggccagacac gcgaacatgc tcttctggct      420

tatacactcg gggttaaaca gctcatagta ggagtgaata agatggactc cactgaaccc      480

gcctattcag agaagcgcta tgacgaaatt gtaaaggagg tctcagcata tattaaaaaa      540

attggctata acccagccac ggtgccattc gtcccgatta gtggatggca tggtgacaat      600

atgctggaac caagtcccaa tatgccttgg tttaagggtt ggaaagtaga gcggaaagag      660

ggtaatgctt ccggcgtgtc attgctggag gcgcttgaca cgatactccc acccacaagg      720

ccaactgata agccactccg attgcccttg caggacgtgt acaagattgg gggaattggg      780

actgtgcccg tcgggcgcgt ggagacgggc atcctcagac ctgggatggt agtcactttt      840

gcccccgtca acataacgac tgaagttaaa tcagtggaaa tgcatcacga agctttgagt      900

gaggcgcttc ccggagataa cgttggattt aatgtcaaaa atgtctccgt taaagatata      960

agaagaggaa acgtctgcgg tgactcaaag tcagacccac cacaggaggc tgctcaattt     1020

acgagtcaag taataattct gaatcaccct gggcaaataa gtgcgggata ctctccagtc     1080

atcgattgtc acaccgccca tattgcatgt aagttcgcag aacttaagga aaagatcgac     1140

cgaagaagcg gaaaaaaatt ggaagataat ccgaaaagtt tgaaaagcgg tgacgcggcg     1200

attgtagaga tggtccctgg caaaccgatg tgtgtggagt ctttcagtca atatccacca     1260

ctcggtcgct ttgccgtgcg ggatatgcga cagaccgttg ctgtcggcgt aataaaaaac     1320

gtcgaaaaaa agagcggtgg ggctggaaaa gttacaaaat ccgctcaaaa ggcacagaag     1380

gcgggcaagt ga                                                         1392


<210>  6
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized eEF1A2 polynucleotide variant

<400>  6
atgggtaaag aaaagaccca cattaacata gtagtaatcg gtcatgttga ctctgggaaa       60

agcactacta ccggacattt gatctataaa tgtgggggca tcgacaaaag aacgatagag      120

aagtttgaga aggaggcggc ggagatgggt aaaggtagtt ttaagtacgc ttgggttttg      180

gacaaattga aagccgagcg cgagcgcggc attaccattg acatttctct ctggaaattc      240

gaaactacga agtattatat aacaataata gacgcccccg gccatcggga ctttattaaa      300

aacatgatta caggaactag ccaagcagat tgtgctgtgc tgatagtagc ggcaggggtc      360

ggggagttcg aagcaggcat ctctaaaaat ggacaaactc gagagcacgc cttgttggct      420

tataccttgg gcgtaaagca gctgatcgta ggagttaata aaatggattc cactgaaccc      480

gcatatagcg aaaagcgata tgacgaaata gtaaaggaag tctcagctta tatcaagaaa      540

atcggttaca atcctgcgac ggttccattc gttcctatct ccgggtggca cggcgataat      600

atgcttgagc ccagtcccaa tatgccctgg ttcaaggggt ggaaggttga gaggaaggaa      660

ggcaatgcat caggcgtcag cttgttggaa gctctcgaca ccatcctgcc gcccacgagg      720

cccacagaca aaccgttgcg actgcctctt caagatgtat acaaaatagg cgggatagga      780

accgtgccgg ttggacgagt agagacgggt atactgcggc ccggaatggt cgtgacgttt      840

gcacccgtga atataactac tgaggtgaag agcgtcgaga tgcaccatga agcgctgagt      900

gaagctctcc ctggcgataa cgtagggttc aacgtgaaaa acgtaagtgt aaaggatata      960

aggcgcggaa atgtatgtgg tgacagtaaa agcgacccgc cgcaagaggc ggcgcaattc     1020

acatcacagg taataatatt gaatcacccc ggccaaattt ccgcaggcta ctcaccagtc     1080

atagattgcc acaccgccca catagcttgt aagttcgctg agttgaaaga gaagattgat     1140

agacgaagtg ggaagaaact tgaagacaat ccgaagtccc tgaagtccgg tgacgcagcg     1200

attgtagaaa tggtaccggg caagccaatg tgtgtagagt ctttcagcca gtacccacca     1260

ctggggcggt tcgcggtgcg agacatgagg caaacggttg cggtcggcgt cattaaaaat     1320

gtcgaaaaaa agagtggcgg tgcaggtaag gtcacaaaaa gcgcacaaaa ggcccagaaa     1380

gccggtaagt ga                                                         1392


<210>  7
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized eEF1A2 polynucleotide variant

<400>  7
atgggaaagg aaaaaactca cataaacatt gtcgtcatcg gtcacgtaga cagtggcaaa       60

tcaacgacca ctggacatct catctataag tgtggcggta ttgacaaacg cactatcgag      120

aaattcgaaa aggaggctgc tgagatgggc aaaggctctt tcaagtacgc atgggtcctg      180

gataagctga aagcggagcg agagagaggg atcaccatcg atatatctct gtggaaattt      240

gaaaccacca agtactacat cacaattatt gatgccccag gtcataggga ttttatcaag      300

aacatgatca ccgggacaag ccaagccgac tgcgcagttc tcatagtggc ggctggagta      360

ggggagtttg aagcagggat atctaagaat ggacagaccc gcgagcacgc cttgctggcc      420

tacaccctgg gagtgaagca gctcatagtt ggcgtcaata agatggacag caccgaaccc      480

gcctacagtg agaagaggta tgacgagatt gtgaaggagg tttctgctta cattaaaaag      540

attggctata acccagctac tgtcccattc gttccaatca gcggctggca cggtgataac      600

atgctggagc ctagtcccaa catgccgtgg ttcaaggggt ggaaggttga acgcaaggag      660

gggaatgcct caggcgtttc cctgctggag gccctcgata caatactccc cccgacccgg      720

cctacagata aaccgctgcg actgcctctt caggacgtgt ataaaatcgg gggaatcggc      780

acagtgcccg tgggcagggt agagactggc atcttgcggc ctggaatggt agtcaccttt      840

gccccggtta atatcacaac ggaggtgaaa tctgtggaga tgcatcacga agcactgagc      900

gaggctctgc ctggtgacaa cgtgggattt aacgtcaaaa acgtgtcagt caaggacatc      960

cgccgcggta acgtttgcgg agattctaag tccgatcccc cccaggaggc agcccaattt     1020

acctcccaag tgatcattct gaatcaccca ggccaaattt ccgccgggta ttcccctgtg     1080

attgactgtc acacagcaca catcgcatgc aaattcgccg aactcaagga gaaaattgat     1140

cggagaagcg gtaaaaaact ggaggacaac ccaaagtccc tcaagtctgg ggatgccgcc     1200

atcgtggaga tggtaccagg caaacctatg tgcgtggaaa gttttagcca gtaccctcca     1260

ctgggtcgct ttgctgttcg ggatatgcgg cagacagtag cggttggggt cataaaaaac     1320

gtcgagaaaa agagcggagg agctgggaaa gttaccaaat ccgcacagaa ggcacaaaaa     1380

gccggaaaat ga                                                         1392


<210>  8
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized eEF1A2 polynucleotide variant

<400>  8
atgggcaaag agaaaacaca tattaacatt gttgttatcg ggcacgttga tagcggcaag       60

tccactacca ctggccatct gatttacaag tgcggcggaa tcgataaacg aactattgaa      120

aagttcgaaa aagaagccgc cgagatggga aagggctcct ttaaatacgc ttgggtcctc      180

gataaactca aagcagaacg ggagagagga atcaccatcg atatatcctt gtggaagttc      240

gaaactacaa aatattacat taccatcatt gatgcgcctg ggcaccgcga cttcattaag      300

aacatgatta ctggcacctc tcaagccgac tgcgcagtgt tgatcgtagc cgcaggcgtc      360

ggggagttcg aagctgggat cagcaagaac gggcagacta gggaacacgc tctgctcgca      420

tatactcttg gcgtgaaaca gttgatcgtt ggcgtgaaca agatggattc aactgagcct      480

gcctattctg agaaacgata cgacgagatt gtgaaagagg tttcagctta catcaagaaa      540

attgggtata atcccgcaac agttcccttc gtgcccatct ctgggtggca cggcgacaac      600

atgctcgaac catccccaaa tatgccatgg ttcaagggat ggaaggtgga gcgcaaagaa      660

ggcaacgcct ccggagtgtc tctgctcgag gccctggaca ccattctgcc cccaacacga      720

cccactgata agcctctgag actgccactg caagacgttt acaaaattgg gggaattgga      780

accgtgcctg tgggtcgggt ggaaaccgga atcctcagac ccggcatggt ggtcaccttc      840

gcaccagtga atataacgac agaggtcaaa tctgtggaga tgcaccatga ggcattgagc      900

gaggcactcc caggagacaa cgtgggtttc aacgtgaaaa atgtctcagt taaggacatc      960

cgacgcggca acgtgtgcgg agatagcaaa tctgaccccc cccaggaggc cgctcaattc     1020

acaagtcagg ttatcatcct taatcaccct ggccaaatat ctgcaggcta cagccccgtg     1080

atcgattgtc acacagctca tatcgcctgt aaatttgctg aactcaaaga aaagattgac     1140

cgcagatcag gaaaaaagct ggaggacaac cctaaaagtc tgaagtccgg cgacgctgcc     1200

atcgtggaga tggtccctgg gaaacccatg tgcgtggagt ccttttctca gtacccccct     1260

ctgggacgat tcgccgtgcg cgacatgaga cagactgtcg ccgtgggcgt cattaaaaat     1320

gtggaaaaaa aatcaggagg tgcagggaaa gtgacaaaga gtgcccagaa agcacagaag     1380

gctggcaagt ga                                                         1392


<210>  9
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human eEF1A2 with Kozak sequence

<400>  9
gccaccatgg gcaaggagaa gacccacatc aacatcgtgg tcatcggcca cgtggactcc       60

ggaaagtcca ccaccacggg ccacctcatc tacaaatgcg gaggtattga caaaaggacc      120

attgagaagt tcgagaagga ggcggctgag atggggaagg gatccttcaa gtatgcctgg      180

gtgctggaca agctgaaggc ggagcgtgag cgcggcatca ccatcgacat ctccctctgg      240

aagttcgaga ccaccaagta ctacatcacc atcatcgatg cccccggcca ccgcgacttc      300

atcaagaaca tgatcacggg tacatcccag gcggactgcg cagtgctgat cgtggcggcg      360

ggcgtgggcg agttcgaggc gggcatctcc aagaatgggc agacgcggga gcatgccctg      420

ctggcctaca cgctgggtgt gaagcagctc atcgtgggcg tgaacaaaat ggactccaca      480

gagccggcct acagcgagaa gcgctacgac gagatcgtca aggaagtcag cgcctacatc      540

aagaagatcg gctacaaccc ggccaccgtg ccctttgtgc ccatctccgg ctggcacggt      600

gacaacatgc tggagccctc ccccaacatg ccgtggttca agggctggaa ggtggagcgt      660

aaggagggca acgcaagcgg cgtgtccctg ctggaggccc tggacaccat cctgcccccc      720

acgcgcccca cggacaagcc cctgcgcctg ccgctgcagg acgtgtacaa gattggcggc      780

attggcacgg tgcccgtggg ccgggtggag accggcatcc tgcggccggg catggtggtg      840

acctttgcgc cagtgaacat caccactgag gtgaagtcag tggagatgca ccacgaggct      900

ctgagcgaag ctctgcccgg cgacaacgtc ggcttcaatg tgaagaacgt gtcggtgaag      960

gacatccggc ggggcaacgt gtgtggggac agcaagtctg acccgccgca ggaggctgct     1020

cagttcacct cccaggtcat catcctgaac cacccggggc agattagcgc cggctactcc     1080

ccggtcatcg actgccacac agcccacatc gcctgcaagt ttgcggagct gaaggagaag     1140

attgaccggc gctctggcaa gaagctggag gacaacccca agtccctgaa gtctggagac     1200

gcggccatcg tggagatggt gccgggaaag cccatgtgtg tggagagctt ctcccagtac     1260

ccgcctctcg gccgcttcgc cgtgcgcgac atgaggcaga cggtggccgt aggcgtcatc     1320

aagaacgtgg agaagaagag cggcggcgcc ggcaaggtca ccaagtcggc gcagaaggcg     1380

cagaaggcgg gcaag                                                      1395


<210>  10
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence motif

<400>  10
gccaccatgg                                                              10


<210>  11
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Alternative Kozak sequence motif

<400>  11
gccgccrcca ugg                                                          13


<210>  12
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Alternative Kozak sequence motif

<400>  12
gacaccaugg                                                              10


<210>  13
<211>  168
<212>  DNA
<213>  Adeno-associated virus

<400>  13
tacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag       60

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc      120

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgc                   168


<210>  14
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - CAG promoter in part Human betaherpesvirus 5

<400>  14
acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat       60

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      120

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      180

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      240

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga      300

ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt      360

gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggcgcg      420

cgccaggcgg ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg      480

cagccaatca gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc      540

ggccctataa aaagcgaagc gcgcggcggg cgg                                   573


<210>  15
<211>  736
<212>  PRT
<213>  Adeno-associated virus 9

<400>  15

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  16
<211>  220
<212>  DNA
<213>  Human betaherpesvirus 5

<400>  16
tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat       60

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      120

actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac      180

ggtgggaggt ctatataagc agagctcgtt tagtgaaccg                            220


<210>  17
<211>  583
<212>  DNA
<213>  Human betaherpesvirus 5

<400>  17
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgt                        583


<210>  18
<211>  141
<212>  DNA
<213>  Adeno-associated virus

<400>  18
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  19
<211>  168
<212>  DNA
<213>  Adeno-associated virus

<400>  19
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgta                   168


<210>  20
<211>  170
<212>  DNA
<213>  Adeno-associated virus

<400>  20
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta                 170


<210>  21
<211>  141
<212>  DNA
<213>  Adeno-associated virus

<400>  21
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  22
<211>  124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - vector filler sequence

<400>  22
gcggcaattc agtcgataac tataacggtc ctaaggtagc gatttaaata cgcgctctct       60

taaggtagcc ccgggacgcg tcaattgact acaaaccgag tatctgcaga gggccctgcg      120

tatg                                                                   124


<210>  23
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - vector filler sequence

<400>  23
cttctgaggc ggaaagaacc agatcctctc ttaaggtagc atcgagattt aaattaggga       60

taacagggta atggcgcggg ccgc                                              84


<210>  24
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - vector filler sequence

<400>  24
gttacccagg ctggagtgca gtggcacatt tctgctcact gcaacctcct cctccctggg       60

ttc                                                                     63


<210>  25
<211>  253
<212>  DNA
<213>  Homo sapiens

<400>  25
gcccagcacc ccaaggcggc caacgccaaa actctccctc ctcctcttcc tcaatctcgc       60

tctcgctctt tttttttttc gcaaaaggag gggagagggg gtaaaaaaat gctgcactgt      120

gcggcgaagc cggtgagtga gcggcgcggg gccaatcagc gtgcgccgtt ccgaaagttg      180

ccttttatgg ctcgagcggc cgcggcggcg ccctataaaa cccagcggcg cgacgcgcca      240

ccaccgccga gtc                                                         253


<210>  26
<211>  281
<212>  DNA
<213>  Gallus gallus

<400>  26
ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct ccccaccccc       60

aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg a                          281


<210>  27
<211>  455
<212>  DNA
<213>  Homo sapiens

<400>  27
caacctttgg agctaagcca gcaatggtag agggaagatt ctgcacgtcc cttccaggcg       60

gcctccccgt caccaccccc cccaacccgc cccgaccgga gctgagagta attcatacaa      120

aaggactcgc ccctgccttg gggaatccca gggaccgtcg ttaaactccc actaacgtag      180

aacccagaga tcgctgcgtt cccgccccct cacccgcccg ctctcgtcat cactgaggtg      240

gagaatagca tgcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag      300

tccccgagaa gttgggggga ggggtcggca attgaacggg tgcctagaga aggtggcgcg      360

gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag      420

aaccgtatat aagtgcagta gtcgccgtga acgtt                                 455


<210>  28
<211>  401
<212>  DNA
<213>  Homo sapiens

<400>  28
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct c                          401


<210>  29
<211>  422
<212>  DNA
<213>  Homo sapiens

<400>  29
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tc                                                                     422


<210>  30
<211>  281
<212>  DNA
<213>  Homo sapiens

<400>  30
acttgtggac aaagtttgct ctattccacc tcctccaggc cctccttggg tccatcaccc       60

caggggtgct gggtccatcc cacccccagg cccacacagg cttgcagtat tgtgtgcggt      120

atggtcaggg cgtccgagag caggtttcgc agtggaaggc aggcaggtgt tggggaggca      180

gttaccgggg caacgggaac agggcgtttt ggaggtggtt gccatgggga cctggatgct      240

gacgaaggct cgcgaggctg tgagcagcca cagtgccctg c                          281


<210>  31
<211>  293
<212>  DNA
<213>  Human betaherpesvirus 5

<400>  31
acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat       60

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      120

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      180

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      240

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta cca             293


<210>  32
<211>  953
<212>  DNA
<213>  Homo sapiens

<400>  32
cgcgtccgcc cgcgagcaca gagcctcgcc tttgccgatc cgccgcccgt ccacacccgc       60

cgccaggtaa gcccggccag ccgaccgggg catgcggccg cggcccttcg cccgtgcaga      120

gccgccgtct gggccgcagc ggggggcgca tggggcggaa ccggaccgcc gtggggggcg      180

cgggagaagc ccctgggcct ccggagatgg gggacacccc acgccagttc gcaggcgcga      240

ggccgcgctc gggcgggcgc gctccggggg tgccgctctc ggggcggggg caaccggcgg      300

ggtctttgtc tgagccgggc tcttgccaat ggggatcgca cggtgggcgc ggcgtagccc      360

ccgtcaggcc cggtgggggc tggggcgcca tgcgcgtgcg cgctggtcct ttgggcgcta      420

actgcgtgcg cgctgggaat tggcgctaat tgcgcgtgcg cgctgggact caatggcgct      480

aatcgcgcgt gcgttctggg gcccgggcgc ttgcgccact tcctgcccga gccgctggcg      540

cccgagggtg tggccgctgc gtgcgcgcgc gcgacccggt cgctgtttga accgggcgga      600

ggcggggctg gcgcccggtt gggagggggt tggggcctgg cttcctgccg cgcgccgcgg      660

ggacgcctcc gaccagtgtt tgccttttat ggtaataacg cggccggccc ggcttccttt      720

gtccccaatc tgggcgcgcg ccggcgcccc ctggcggcct aaggactcgg cgcgccggaa      780

gtggccaggg cggcagcggc tgctcttggc ggccccgagg tgactatagc cttcttttgt      840

gtcttgatag ttcgccagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc      900

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttc             953


<210>  33
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Chicken beta-actin exon/intron plus rabbit globin 
       intron

<400>  33
gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc       60

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      120

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      180

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg      240

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc      300

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc      360

ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc      420

gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc      480

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc      540

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg      600

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc      660

tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag      720

ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc      780

tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc      840

cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg      900

ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc      960

ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg     1020

ggcaacgtgc tggttattgt gctgtctcat cattttggca aagaattc                  1068


<210>  34
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  34
agtctgcggt gggcagcgga ggagtcgtgt cgtgcctgag agcgcagctg tgctcctggg       60

caccgcgcag tccgcccccg cggctcctgg ccagaccacc cctaggaccc cctgccccaa      120

gtcgca                                                                 126


<210>  35
<211>  121
<212>  DNA
<213>  Human betaherpesvirus 5

<400>  35
tcagatcgcc tggagaggcc atccacgctg ttttgacctc catagtggac accgggaccg       60

atccagcctc cgcggccggg aacggtgcat tggaacgcgg attccccgtg ccaagagtga      120

c                                                                      121


<210>  36
<211>  512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - adenovirus derived enhancer element

<400>  36
ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca       60

aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac      120

tccgccaccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa      180

ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg      240

gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt aggcggtctt      300

gagacggcgg atggtcgagg tgaggtgtgg caggcttgag atccagctgt tggggtgagt      360

actccctctc aaaagcgggc attacttctg cgctaagatt gtcagtttcc aaaaacgagg      420

aggatttgat attcacctgg cccgatctgg ccatacactt gagtgacaat gacatccact      480

ttgcctttct ctccacaggt gtccactccc ag                                    512


<210>  37
<211>  956
<212>  DNA
<213>  Homo sapiens

<400>  37
ctttttcgca acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg       60

cctggcctct ttacgggtta tggcccttgc gtgccttgaa ttacttccac ctggctccag      120

tacgtgattc ttgatcccga gctggagcca ggggcgggcc ttgcgcttta ggagcccctt      180

cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt      240

ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat      300

gacgtgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caggatctgc      360

acactggtat ttcggttttt gggcccgcgg ccggcgacgg ggcccgtgcg tcccagcgca      420

catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc      480

aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg      540

cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc      600

ctgctccagg gggctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac      660

ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccacggagt      720

accgggcgcc gtccaggcac ctcgattagt tctggagctt ttggagtacg tcgtctttag      780

gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag      840

ttaggccagc ttggcacttg atgtaattct ccttggaatt tggccttttt gagtttggat      900

cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcag          956


<210>  38
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  38
gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg       60

ccttgaatta cttccacctg gctgcagtac gtgattcttg atcccgagct tcgggttgga      120

agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt      180

gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt      240

ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt      300

tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt      360

tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg      420

ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct      480

ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg      540

tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca      600

aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg      660

gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg      720

cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt      780

tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac      840

ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag      900

cctcagacag tggttcaaag tttttttctt ccatttcag                             939


<210>  39
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  39
tcagaagccc cgggctcgtc agtcaaaccg gttctctgtt tgcactcggc agcacgggca       60

ggcaagtggt ccctaggttc ggg                                               83


<210>  40
<211>  476
<212>  DNA
<213>  Homo sapiens

<400>  40
gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca      240

ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata      300

taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc      360

tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga      420

gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacag          476


<210>  41
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - mutated woodchuck hepatitis regulatory element

<400>  41
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  42
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - mutated woodchuck hepatitis regulatory element

<400>  42
tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc       60

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat      120

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg      180

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg      240

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat      300

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt      360

gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc      420

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa      480

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg      540

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgca                   588


<210>  43
<211>  755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - mutated woodchuck hepatitis regulatory element

<400>  43
ttcctgttaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact       60

atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg      120

cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg      180

aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa      240

cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc      300

ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg      360

ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg tcctttccgc      420

ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt      480

cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc      540

cgcctcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgccca      600

tgtatctttt tcacctgtgc cttgtttttg cctgtgttcc gcgtcctact tttcaagcct      660

ccaagctgtg ccttgggcgg ctttggggca tggacataga tccctataaa gaatttggtt      720

catcttatca gttgttgaat tttcttcctt tggac                                 755


<210>  44
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAX motif

<400>  44
tgtgtgataa tg                                                           12


<210>  45
<211>  810
<212>  DNA
<213>  Homo sapiens

<400>  45
ctgttctcat cacatcatat caaggttata taccatcaat attgccacag atgttactta       60

gccttttaat atttctctaa tttagtgtat atgcaatgat agttctctga tttctgagat      120

tgagtttctc atgtgtaatg attatttaga gtttctcttt catctgttca aatttttgtc      180

tagttttatt ttttactgat ttgtaagact tctttttata atctgcatat tacaattctc      240

tttactgggg tgttgcaaat attttctgtc attctatggc ctgacttttc ttaatggttt      300

tttaatttta aaaataagtc ttaatattca tgcaatctaa ttaacaatct tttctttgtg      360

gttaggactt tgagtcataa gaaatttttc tctacactga agtcatgatg gcatgcttct      420

atattatttt ctaaaagatt taaagttttg ccttctccat ttagacttat aattcactgg      480

aatttttttg tgtgtatggt atgacatatg ggttcccttt tattttttac atataaatat      540

atttccctgt ttttctaaaa aagaaaaaga tcatcatttt cccattgtaa aatgccatat      600

ttttttcata ggtcacttac atatatcaat gggtctgttt ctgagctcta ctctatttta      660

tcagcctcac tgtctatccc cacacatctc atgctttgct ctaaatcttg atatttagtg      720

gaacattctt tcccattttg ttctacaaga atatttttgt tattgtcttt gggctttcta      780

tatacatttt gaaatgaggt tgacaagtta                                       810


<210>  46
<211>  726
<212>  DNA
<213>  Hepatitis B virus

<400>  46
ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg       60

ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa      120

aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc      180

tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca      240

ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc      300

cgatccatac tgcggaactc ctagccgctt gttttgctcg cagcaggtct ggagcaaacc      360

tcatcgggac cgacaattct gtcgtactct cccgcaagta tacatcgttt ccatggctgc      420

taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc      480

tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc      540

tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt      600

ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt      660

gaacgcccac cggaacctgc ccaaggtctt gcataagagg actcttggac tttcagcaat      720

gtcatc                                                                 726


<210>  47
<211>  755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - HepB derived enhancer element

<400>  47
ttcctgtaaa caggcctatt gattggaaag tttgtcaacg aattgtgggt cttttggggt       60

ttgctgcccc ttttacgcaa tgtggatatc ctgctttaat gcctttatat gcatgtatac      120

aagcaaaaca ggcttttact ttctcgccaa cttacaaggc ctttctcagt aaacagtata      180

tgacccttta ccccgttgct cggcaacggc ctggtctgtg ccaagtgttt gctgacgcaa      240

cccccactgg ttggggcttg gccataggcc atcagcgcat gcgtggaacc tttgtgtctc      300

ctctgccgat ccatactgcg gaactcctag ccgcttgttt tgctcgcagc tggactggag      360

caaacctcat cgggaccgac aattctgtcg tactctcccg caagcactca ccgtttccgc      420

ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt      480

cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc      540

cgcctcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgccca      600

tgtatctttt tcacctgtgc cttgtttttg cctgtgttcc gcgtcctact tttcaagcct      660

ccaagctgtg ccttgggcgg ctttggggca tggacataga tccctataaa gaatttggtt      720

catcttatca gttgttgaat tttcttcctt tggac                                 755


<210>  48
<211>  94
<212>  DNA
<213>  Homo sapiens

<400>  48
gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc       60

tccttgcacc ggcccttcct ggtctttgaa taaa                                   94


<210>  49
<211>  596
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  49
attcgagcat cttaccgcca tttattccca tatttgttct gtttttcttg atttgggtat       60

acatttaaat gttaataaaa caaaatggtg gggcaatcat ttacattttt agggatatgt      120

aattactagt tcaggtgtat tgccacaaga caaacatgtt aagaaacttt cccgttattt      180

acgctctgtt cctgttaatc aacctctgga ttacaaaatt tgtgaaagat tgactgatat      240

tcttaactat gttgctcctt ttacgctgtg tggatatgct gctttaatgc ctctgtatca      300

tgctattgct tcccgtacgg ctttcgtttt ctcctccttg tataaatcct ggttgctgtc      360

tctttatgag gagttgtggc ccgttgtccg tcaacgtggc gtggtgtgct ctgtgtttgc      420

tgacgcaacc cccactggct ggggcattgc caccacctgt caactccttt ctgggacttt      480

cgctttcccc ctcccgatcg ccacggcaga actcatcgcc gcctgccttg cccgctgctg      540

gacaggggct aggttgctgg gcactgataa ttccgtggtg ttgtcgggga agggcc          596


<210>  50
<211>  387
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  50
tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc       60

actcggaaga acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta      120

gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg      180

tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac      240

ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa      300

attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat      360

agctgtccct cttctcttat ggagatc                                          387


<210>  51
<211>  251
<212>  DNA
<213>  Bos taurus

<400>  51
ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac       60

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca      120

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aatacaatag      180

caggcatgct ggggatgcgg tgggctctat gggtacccag gtgctgaaga attgacccgg      240

ttcctcctgg g                                                           251


<210>  52
<211>  251
<212>  DNA
<213>  Bos taurus

<400>  52
ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac       60

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca      120

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag      180

caggcatgct ggggatgcgg tgggctctat gggtacccag gtgctgaaga attgacccgg      240

ttcctcctgg g                                                           251


<210>  53
<211>  225
<212>  DNA
<213>  Bos taurus

<400>  53
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  54
<211>  202
<212>  DNA
<213>  Homo sapiens

<400>  54
ctgcccgggt ggcatccctg tgacccctcc ccagtgcctc tcctggccct ggaagttgcc       60

actccagtgc ccaccagcct tgtcctaata aaattaagtt gcatcatttt gtctgactag      120

gtgtccttct ataatattat ggggtggagg ggggtggtat ggagcaaggg gcccaagttg      180

ggaagaaacc tgtagggcct gc                                               202


<210>  55
<211>  3144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - vector genome construct

<400>  55
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcaatt cagtcgataa ctataacggt cctaaggtag      180

cgatttaaat acgcgctctc ttaaggtagc cccgggacgc gtcaattgac tacaaaccga      240

gtatctgcag agggccctgc gtatgagtgc aagtgggttt taggaccagg atgaggcggg      300

gtgggggtgc ctacctgacg accgaccccg acccactgga caagcaccca acccccattc      360

cccaaattgc gcatccccta tcagagaggg ggaggggaaa caggatgcgg cgaggcgcgt      420

gcgcactgcc agcttcagca ccgcggacag tgccttcgcc cccgcctggc ggcgcgcgcc      480

accgccgcct cagcactgaa ggcgcgctga cgtcactcgc cggtcccccg caaactcccc      540

ttcccggcca ccttggtcgc gtccgcgccg ccgccggccc agccggaccg caccacgcga      600

ggcgcgagat aggggggcac gggcgcgacc atctgcgctg cggcgccggc gactcagcgc      660

tgcctcagtc tgcggtgggc agcggaggag tcgtgtcgtg cctgagagcg cagatgggca      720

aggagaagac ccacatcaac atcgtggtca tcggccacgt ggactccgga aagtccacca      780

ccacgggcca cctcatctac aaatgcggag gtattgacaa aaggaccatt gagaagttcg      840

agaaggaggc ggctgagatg gggaagggat ccttcaagta tgcctgggtg ctggacaagc      900

tgaaggcgga gcgtgagcgc ggcatcacca tcgacatctc cctctggaag ttcgagacca      960

ccaagtacta catcaccatc atcgatgccc ccggccaccg cgacttcatc aagaacatga     1020

tcacgggtac atcccaggcg gactgcgcag tgctgatcgt ggcggcgggc gtgggcgagt     1080

tcgaggcggg catctccaag aatgggcaga cgcgggagca tgccctgctg gcctacacgc     1140

tgggtgtgaa gcagctcatc gtgggcgtga acaaaatgga ctccacagag ccggcctaca     1200

gcgagaagcg ctacgacgag atcgtcaagg aagtcagcgc ctacatcaag aagatcggct     1260

acaacccggc caccgtgccc tttgtgccca tctccggctg gcacggtgac aacatgctgg     1320

agccctcccc caacatgccg tggttcaagg gctggaaggt ggagcgtaag gagggcaacg     1380

caagcggcgt gtccctgctg gaggccctgg acaccatcct gccccccacg cgccccacgg     1440

acaagcccct gcgcctgccg ctgcaggacg tgtacaagat tggcggcatt ggcacggtgc     1500

ccgtgggccg ggtggagacc ggcatcctgc ggccgggcat ggtggtgacc tttgcgccag     1560

tgaacatcac cactgaggtg aagtcagtgg agatgcacca cgaggctctg agcgaagctc     1620

tgcccggcga caacgtcggc ttcaatgtga agaacgtgtc ggtgaaggac atccggcggg     1680

gcaacgtgtg tggggacagc aagtctgacc cgccgcagga ggctgctcag ttcacctccc     1740

aggtcatcat cctgaaccac ccggggcaga ttagcgccgg ctactccccg gtcatcgact     1800

gccacacagc ccacatcgcc tgcaagtttg cggagctgaa ggagaagatt gaccggcgct     1860

ctggcaagaa gctggaggac aaccccaagt ccctgaagtc tggagacgcg gccatcgtgg     1920

agatggtgcc gggaaagccc atgtgtgtgg agagcttctc ccagtacccg cctctcggcc     1980

gcttcgccgt gcgcgacatg aggcagacgg tggccgtagg cgtcatcaag aacgtggaga     2040

agaagagcgg cggcgccggc aaggtcacca agtcggcgca gaaggcgcag aaggcgggca     2100

agtgaaatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg     2160

ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt     2220

cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg     2280

agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc     2340

ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc     2400

tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc     2460

ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc     2520

tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg     2580

ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc     2640

gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcctgtgc     2700

cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag     2760

gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta     2820

ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag     2880

acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca     2940

gatcctctct taaggtagca tcgagattta aattagggat aacagggtaa tggcgcgggc     3000

cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     3060

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg     3120

agcgagcgcg cagctgcctg cagg                                            3144


<210>  56
<211>  3035
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - vector genome construct

<400>  56
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtaag tgcaagtggg      180

ttttaggacc aggatgaggc ggggtggggg tgcctacctg acgaccgacc ccgacccact      240

ggacaagcac ccaaccccca ttccccaaat tgcgcatccc ctatcagaga gggggagggg      300

aaacaggatg cggcgaggcg cgtgcgcact gccagcttca gcaccgcgga cagtgccttc      360

gcccccgcct ggcggcgcgc gccaccgccg cctcagcact gaaggcgcgc tgacgtcact      420

cgccggtccc ccgcaaactc cccttcccgg ccaccttggt cgcgtccgcg ccgccgccgg      480

cccagccgga ccgcaccacg cgaggcgcga gatagggggg cacgggcgcg accatctgcg      540

ctgcggcgcc ggcgactcag cgctgcctca gtctgcggtg ggcagcggag gagtcgtgtc      600

gtgcctgaga gcgcaggcca ccatgggcaa ggagaagacc cacatcaaca tcgtggtcat      660

cggccacgtg gactccggaa agtccaccac cacgggccac ctcatctaca aatgcggagg      720

tattgacaaa aggaccattg agaagttcga gaaggaggcg gctgagatgg ggaagggatc      780

cttcaagtat gcctgggtgc tggacaagct gaaggcggag cgtgagcgcg gcatcaccat      840

cgacatctcc ctctggaagt tcgagaccac caagtactac atcaccatca tcgatgcccc      900

cggccaccgc gacttcatca agaacatgat cacgggtaca tcccaggcgg actgcgcagt      960

gctgatcgtg gcggcgggcg tgggcgagtt cgaggcgggc atctccaaga atgggcagac     1020

gcgggagcat gccctgctgg cctacacgct gggtgtgaag cagctcatcg tgggcgtgaa     1080

caaaatggac tccacagagc cggcctacag cgagaagcgc tacgacgaga tcgtcaagga     1140

agtcagcgcc tacatcaaga agatcggcta caacccggcc accgtgccct ttgtgcccat     1200

ctccggctgg cacggtgaca acatgctgga gccctccccc aacatgccgt ggttcaaggg     1260

ctggaaggtg gagcgtaagg agggcaacgc aagcggcgtg tccctgctgg aggccctgga     1320

caccatcctg ccccccacgc gccccacgga caagcccctg cgcctgccgc tgcaggacgt     1380

gtacaagatt ggcggcattg gcacggtgcc cgtgggccgg gtggagaccg gcatcctgcg     1440

gccgggcatg gtggtgacct ttgcgccagt gaacatcacc actgaggtga agtcagtgga     1500

gatgcaccac gaggctctga gcgaagctct gcccggcgac aacgtcggct tcaatgtgaa     1560

gaacgtgtcg gtgaaggaca tccggcgggg caacgtgtgt ggggacagca agtctgaccc     1620

gccgcaggag gctgctcagt tcacctccca ggtcatcatc ctgaaccacc cggggcagat     1680

tagcgccggc tactccccgg tcatcgactg ccacacagcc cacatcgcct gcaagtttgc     1740

ggagctgaag gagaagattg accggcgctc tggcaagaag ctggaggaca accccaagtc     1800

cctgaagtct ggagacgcgg ccatcgtgga gatggtgccg ggaaagccca tgtgtgtgga     1860

gagcttctcc cagtacccgc ctctcggccg cttcgccgtg cgcgacatga ggcagacggt     1920

ggccgtaggc gtcatcaaga acgtggagaa gaagagcggc ggcgccggca aggtcaccaa     1980

gtcggcgcag aaggcgcaga aggcgggcaa gtgatcaacc tctggattac aaaatttgtg     2040

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     2100

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     2160

aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg     2220

tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc     2280

tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct     2340

gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt     2400

cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg     2460

ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc     2520

tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct     2580

ccctttgggc cgcctccccg cactgcccgg gtggcatccc tgtgacccct ccccagtgcc     2640

tctcctggcc ctggaagttg ccactccagt gcccaccagc cttgtcctaa taaaattaag     2700

ttgcatcatt ttgtctgact aggtgtcctt ctataatatt atggggtgga ggggggtggt     2760

atggagcaag gggcccaagt tgggaagaaa cctgtagggc ctgcgttacc caggctggag     2820

tgcagtggca catttctgct cactgcaacc tcctcctccc tgggttctac gtagataagt     2880

agcatggcgg gttaatcatt aactacaagg aacccctagt gatggagttg gccactccct     2940

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     3000

ttgcccgggc ggcctcagtg agcgagcgag cgcgc                                3035


<210>  57
<211>  3263
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - vector genome construct

<400>  57
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtaag tgcaagtggg      180

ttttaggacc aggatgaggc ggggtggggg tgcctacctg acgaccgacc ccgacccact      240

ggacaagcac ccaaccccca ttccccaaat tgcgcatccc ctatcagaga gggggagggg      300

aaacaggatg cggcgaggcg cgtgcgcact gccagcttca gcaccgcgga cagtgccttc      360

gcccccgcct ggcggcgcgc gccaccgccg cctcagcact gaaggcgcgc tgacgtcact      420

cgccggtccc ccgcaaactc cccttcccgg ccaccttggt cgcgtccgcg ccgccgccgg      480

cccagccgga ccgcaccacg cgaggcgcga gatagggggg cacgggcgcg accatctgcg      540

ctgcggcgcc ggcgactcag cgctgcctca gtctgcggtg ggcagcggag gagtcgtgtc      600

gtgcctgaga gcgcagagtc tgcggtgggc agcggaggag tcgtgtcgtg cctgagagcg      660

cagctgtgct cctgggcacc gcgcagtccg cccccgcggc tcctggccag accaccccta      720

ggaccccctg ccccaagtcg cagccaccat gggcaaggag aagacccaca tcaacatcgt      780

ggtcatcggc cacgtggact ccggaaagtc caccaccacg ggccacctca tctacaaatg      840

cggaggtatt gacaaaagga ccattgagaa gttcgagaag gaggcggctg agatggggaa      900

gggatccttc aagtatgcct gggtgctgga caagctgaag gcggagcgtg agcgcggcat      960

caccatcgac atctccctct ggaagttcga gaccaccaag tactacatca ccatcatcga     1020

tgcccccggc caccgcgact tcatcaagaa catgatcacg ggtacatccc aggcggactg     1080

cgcagtgctg atcgtggcgg cgggcgtggg cgagttcgag gcgggcatct ccaagaatgg     1140

gcagacgcgg gagcatgccc tgctggccta cacgctgggt gtgaagcagc tcatcgtggg     1200

cgtgaacaaa atggactcca cagagccggc ctacagcgag aagcgctacg acgagatcgt     1260

caaggaagtc agcgcctaca tcaagaagat cggctacaac ccggccaccg tgccctttgt     1320

gcccatctcc ggctggcacg gtgacaacat gctggagccc tcccccaaca tgccgtggtt     1380

caagggctgg aaggtggagc gtaaggaggg caacgcaagc ggcgtgtccc tgctggaggc     1440

cctggacacc atcctgcccc ccacgcgccc cacggacaag cccctgcgcc tgccgctgca     1500

ggacgtgtac aagattggcg gcattggcac ggtgcccgtg ggccgggtgg agaccggcat     1560

cctgcggccg ggcatggtgg tgacctttgc gccagtgaac atcaccactg aggtgaagtc     1620

agtggagatg caccacgagg ctctgagcga agctctgccc ggcgacaacg tcggcttcaa     1680

tgtgaagaac gtgtcggtga aggacatccg gcggggcaac gtgtgtgggg acagcaagtc     1740

tgacccgccg caggaggctg ctcagttcac ctcccaggtc atcatcctga accacccggg     1800

gcagattagc gccggctact ccccggtcat cgactgccac acagcccaca tcgcctgcaa     1860

gtttgcggag ctgaaggaga agattgaccg gcgctctggc aagaagctgg aggacaaccc     1920

caagtccctg aagtctggag acgcggccat cgtggagatg gtgccgggaa agcccatgtg     1980

tgtggagagc ttctcccagt acccgcctct cggccgcttc gccgtgcgcg acatgaggca     2040

gacggtggcc gtaggcgtca tcaagaacgt ggagaagaag agcggcggcg ccggcaaggt     2100

caccaagtcg gcgcagaagg cgcagaaggc gggcaagtga tcaacctctg gattacaaaa     2160

tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg     2220

ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct     2280

tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg     2340

gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct     2400

gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg     2460

ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg     2520

tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc ctgtgttgcc acctggattc     2580

tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc     2640

gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc     2700

ggatctccct ttgggccgcc tccccgcagc tggagcctcg gtagccgttc ctcctgcccg     2760

ctgggcctcc caacgggccc tcctcccctc cttgcaccgg cccttcctgg tctttgaata     2820

aattcattgc ctgcccgggt ggcatccctg tgacccctcc ccagtgcctc tcctggccct     2880

ggaagttgcc actccagtgc ccaccagcct tgtcctaata aaattaagtt gcatcatttt     2940

gtctgactag gtgtccttct ataatattat ggggtggagg ggggtggtat ggagcaaggg     3000

gcccaagttg ggaagaaacc tgtagggcct gcgttaccca ggctggagtg cagtggcaca     3060

tttctgctca ctgcaacctc ctcctccctg ggttctacgt agataagtag catggcgggt     3120

taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     3180

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     3240

cctcagtgag cgagcgagcg cgc                                             3263


<210>  58
<211>  4299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - vector genome construct

<400>  58
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtact ctggagacgc      180

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg      240

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa      300

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca      360

agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac      420

atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc      480

atggtcgagg tgagccccac gttctgcttc actctcccca tctccccccc ctccccaccc      540

ccaattttgt atttatttat tttttaatta ttttgtgcag cgatgggggc gggggggggg      600

ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga ggcggagagg      660

tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg      720

gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg ggagtcgctg cgcgctgcct      780

tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg ccccggctct gactgaccgc      840

gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta attagcgctt      900

ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa agccttgagg ggctccggga      960

gggccctttg tgcgggggga gcggctcggg gggtgcgtgc gtgtgtgtgt gcgtggggag     1020

cgccgcgtgc ggctccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg gcgcggggct     1080

ttgtgcgctc cgcagtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg     1140

ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg ggtgagcagg     1200

gggtgtgggc gcgtcggtcg ggctgcaacc ccccctgcac ccccctcccc gagttgctga     1260

gcacggcccg gcttcgggtg cggggctccg tacggggcgt ggcgcggggc tcgccgtgcc     1320

gggcgggggg tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga     1380

gggctcgggg gaggggcgcg gcggcccccg gagcgccggc ggctgtcgag gcgcggcgag     1440

ccgcagccat tgccttttat ggtaatcgtg cgagagggcg cagggacttc ctttgtccca     1500

aatctgtgcg gagccgaaat ctgggaggcg ccgccgcacc ccctctagcg ggcgcggggc     1560

gaagcggtgc ggcgccggca ggaaggaaat gggcggggag ggccttcgtg cgtcgccgcg     1620

ccgccgtccc cttctccctc tccagcctcg gggctgtccg cggggggacg gctgccttcg     1680

ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg accggcggct ctagagcctc     1740

tgctaaccat gttcatgcct tcttcttttt cctacagcgc caccatgggc aaggagaaga     1800

cccacatcaa catcgtggtc atcggccacg tggactccgg aaagtccacc accacgggcc     1860

acctcatcta caaatgcgga ggtattgaca aaaggaccat tgagaagttc gagaaggagg     1920

cggctgagat ggggaaggga tccttcaagt atgcctgggt gctggacaag ctgaaggcgg     1980

agcgtgagcg cggcatcacc atcgacatct ccctctggaa gttcgagacc accaagtact     2040

acatcaccat catcgatgcc cccggccacc gcgacttcat caagaacatg atcacgggta     2100

catcccaggc ggactgcgca gtgctgatcg tggcggcggg cgtgggcgag ttcgaggcgg     2160

gcatctccaa gaatgggcag acgcgggagc atgccctgct ggcctacacg ctgggtgtga     2220

agcagctcat cgtgggcgtg aacaaaatgg actccacaga gccggcctac agcgagaagc     2280

gctacgacga gatcgtcaag gaagtcagcg cctacatcaa gaagatcggc tacaacccgg     2340

ccaccgtgcc ctttgtgccc atctccggct ggcacggtga caacatgctg gagccctccc     2400

ccaacatgcc gtggttcaag ggctggaagg tggagcgtaa ggagggcaac gcaagcggcg     2460

tgtccctgct ggaggccctg gacaccatcc tgccccccac gcgccccacg gacaagcccc     2520

tgcgcctgcc gctgcaggac gtgtacaaga ttggcggcat tggcacggtg cccgtgggcc     2580

gggtggagac cggcatcctg cggccgggca tggtggtgac ctttgcgcca gtgaacatca     2640

ccactgaggt gaagtcagtg gagatgcacc acgaggctct gagcgaagct ctgcccggcg     2700

acaacgtcgg cttcaatgtg aagaacgtgt cggtgaagga catccggcgg ggcaacgtgt     2760

gtggggacag caagtctgac ccgccgcagg aggctgctca gttcacctcc caggtcatca     2820

tcctgaacca cccggggcag attagcgccg gctactcccc ggtcatcgac tgccacacag     2880

cccacatcgc ctgcaagttt gcggagctga aggagaagat tgaccggcgc tctggcaaga     2940

agctggagga caaccccaag tccctgaagt ctggagacgc ggccatcgtg gagatggtgc     3000

cgggaaagcc catgtgtgtg gagagcttct cccagtaccc gcctctcggc cgcttcgccg     3060

tgcgcgacat gaggcagacg gtggccgtag gcgtcatcaa gaacgtggag aagaagagcg     3120

gcggcgccgg caaggtcacc aagtcggcgc agaaggcgca gaaggcgggc aagtgatcaa     3180

cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt     3240

acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct     3300

ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc     3360

gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg     3420

ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc     3480

acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc     3540

actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctgt     3600

gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca     3660

gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt     3720

cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcagctgga gcctcggtag     3780

ccgttcctcc tgcccgctgg gcctcccaac gggccctcct cccctccttg caccggccct     3840

tcctggtctt tgaataaatt cattgcctgc ccgggtggca tccctgtgac ccctccccag     3900

tgcctctcct ggccctggaa gttgccactc cagtgcccac cagccttgtc ctaataaaat     3960

taagttgcat cattttgtct gactaggtgt ccttctataa tattatgggg tggagggggg     4020

tggtatggag caaggggccc aagttgggaa gaaacctgta gggcctgcgt tacccaggct     4080

ggagtgcagt ggcacatttc tgctcactgc aacctcctcc tccctgggtt ctacgtagat     4140

aagtagcatg gcgggttaat cattaactac aaggaacccc tagtgatgga gttggccact     4200

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     4260

ggctttgccc gggcggcctc agtgagcgag cgagcgcgc                            4299


<210>  59
<211>  735
<212>  PRT
<213>  Adeno-associated virus 2

<400>  59

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  60
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct - AAV9 variant

<400>  60

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide insert

<400>  61

Thr Leu Ala Val Pro Phe Lys 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide insert

<400>  62

Lys Phe Pro Val Ala Leu Thr 
1               5           


<210>  63
<211>  168
<212>  DNA
<213>  Adeno-associated virus

<400>  63
tacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag       60

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc      120

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgc                   168


<210>  64
<211>  851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - eSYN promoter polynucleotide

<400>  64
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gctgcagagg gccctgcgta tgagtgcaag tgggttttag      420

gaccaggatg aggcggggtg ggggtgccta cctgacgacc gaccccgacc cactggacaa      480

gcacccaacc cccattcccc aaattgcgca tcccctatca gagaggggga ggggaaacag      540

gatgcggcga ggcgcgtcgc gactgccagc ttcagcaccg cggacagtgc cttcgccccc      600

gcctggcggc gcgcgccacc gccgcctcag cactgaaggc gcgctgacgt cactcgccgg      660

tcccccgcaa actccccttc ccggccacct tggtcgcgtc cgcgccgccg ccggcccagc      720

cggaccgcac cacgcgaggc gcgagatagg ggggcacggg cgcgaccatc tgcgctgcgg      780

cgccggcgac tcagcgctgc ctcagtctgc ggtgggcagc ggaggagtcg tgtcgtgcct      840

gagagcgcag g                                                           851


