                         SEQUENCE LISTING

<110>  㳱ҽҩƼϺ޹˾
 
<120>  ڲԭǶϿԭ弰Ӧ

<130>  ȨҪ  ˵

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  599
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Val Leu Tyr Ser Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
                165                 170                 175     


Gly Phe Ile Thr Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg 
        195                 200                 205             


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
    210                 215                 220                 


Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp 
                245                 250                 255     


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Tyr Arg His Lys Gln Lys Gly Lys Glu Ser Ser Met Pro Ala Val 
            340                 345                 350         


Thr Tyr Thr Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr Ile Ser 
        355                 360                 365             


Gly Thr Leu Pro His Ser Asn Gly Gly Asn Ala Asn Ser His Tyr Phe 
    370                 375                 380                 


Thr Asn Pro Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser Pro His 
385                 390                 395                 400 


Val Asn Asn Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn Asn Gln 
                405                 410                 415     


Leu Phe Val Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly Pro Val 
            420                 425                 430         


Gly Asp Cys Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly Gly Tyr 
        435                 440                 445             


Leu Asn Glu Leu Gly Ala Phe Gly Leu Asp Arg Ser Tyr Met Gly Lys 
    450                 455                 460                 


Ser Leu Lys Asp Leu Gly Lys Asn Ser Glu Tyr Asn Ser Ser Asn Cys 
465                 470                 475                 480 


Ser Leu Ser Ser Ser Glu Asn Pro Tyr Ala Thr Ile Lys Asp Pro Pro 
                485                 490                 495     


Val Leu Ile Pro Lys Ser Ser Glu Cys Gly Tyr Val Glu Met Lys Ser 
            500                 505                 510         


Pro Ala Arg Arg Asp Ser Pro Tyr Ala Glu Ile Asn Asn Ser Thr Ser 
        515                 520                 525             


Ala Asn Arg Asn Val Tyr Glu Val Glu Pro Thr Val Ser Val Val Gln 
    530                 535                 540                 


Gly Val Phe Ser Asn Asn Gly Arg Leu Ser Gln Asp Pro Tyr Asp Leu 
545                 550                 555                 560 


Pro Lys Asn Ser His Ile Pro Cys His Tyr Asp Leu Leu Pro Val Arg 
                565                 570                 575     


Asp Ser Ser Ser Ser Pro Lys Gln Glu Asp Ser Gly Gly Ser Ser Ser 
            580                 585                 590         


Asn Ser Ser Ser Ser Ser Glu 
        595                 


<210>  2
<211>  601
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Thr Val Ser Ser Thr Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Asp Thr Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr Gly 
                165                 170                 175     


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
            180                 185                 190         


Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
        195                 200                 205             


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr Met 
    210                 215                 220                 


Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly Gly 
                245                 250                 255     


Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Tyr Arg His Lys Gln Lys Gly Lys Glu Ser Ser Met Pro 
            340                 345                 350         


Ala Val Thr Tyr Thr Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr 
        355                 360                 365             


Ile Ser Gly Thr Leu Pro His Ser Asn Gly Gly Asn Ala Asn Ser His 
    370                 375                 380                 


Tyr Phe Thr Asn Pro Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser 
385                 390                 395                 400 


Pro His Val Asn Asn Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn 
                405                 410                 415     


Asn Gln Leu Phe Val Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly 
            420                 425                 430         


Pro Val Gly Asp Cys Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly 
        435                 440                 445             


Gly Tyr Leu Asn Glu Leu Gly Ala Phe Gly Leu Asp Arg Ser Tyr Met 
    450                 455                 460                 


Gly Lys Ser Leu Lys Asp Leu Gly Lys Asn Ser Glu Tyr Asn Ser Ser 
465                 470                 475                 480 


Asn Cys Ser Leu Ser Ser Ser Glu Asn Pro Tyr Ala Thr Ile Lys Asp 
                485                 490                 495     


Pro Pro Val Leu Ile Pro Lys Ser Ser Glu Cys Gly Tyr Val Glu Met 
            500                 505                 510         


Lys Ser Pro Ala Arg Arg Asp Ser Pro Tyr Ala Glu Ile Asn Asn Ser 
        515                 520                 525             


Thr Ser Ala Asn Arg Asn Val Tyr Glu Val Glu Pro Thr Val Ser Val 
    530                 535                 540                 


Val Gln Gly Val Phe Ser Asn Asn Gly Arg Leu Ser Gln Asp Pro Tyr 
545                 550                 555                 560 


Asp Leu Pro Lys Asn Ser His Ile Pro Cys His Tyr Asp Leu Leu Pro 
                565                 570                 575     


Val Arg Asp Ser Ser Ser Ser Pro Lys Gln Glu Asp Ser Gly Gly Ser 
            580                 585                 590         


Ser Ser Asn Ser Ser Ser Ser Ser Glu 
        595                 600     


<210>  3
<211>  810
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Val Leu Tyr Ser Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
                165                 170                 175     


Gly Phe Ile Thr Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg 
        195                 200                 205             


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
    210                 215                 220                 


Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp 
                245                 250                 255     


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu 
            340                 345                 350         


Asp Ser Glu Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg 
        355                 360                 365             


Arg Ala Ile Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu 
    370                 375                 380                 


Gln Asn Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu 
385                 390                 395                 400 


Gly Lys Ile Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn 
                405                 410                 415     


Leu Lys Gln Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met 
            420                 425                 430         


Lys Leu Asp Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu 
        435                 440                 445             


Ala Ala Cys Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu 
    450                 455                 460                 


Gly Val Cys Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val 
465                 470                 475                 480 


Ile Leu Pro Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr 
                485                 490                 495     


Ser Arg Leu Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu 
            500                 505                 510         


Lys Phe Met Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg 
        515                 520                 525             


Asn Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp 
    530                 535                 540                 


Asp Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr 
545                 550                 555                 560 


Ser Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys 
                565                 570                 575     


Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser 
            580                 585                 590         


Asp Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly 
        595                 600                 605             


Met Thr Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu 
    610                 615                 620                 


Leu His Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu 
625                 630                 635                 640 


Tyr Glu Ile Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro 
                645                 650                 655     


Thr Phe Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu 
            660                 665                 670         


Pro Asp Val Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu 
        675                 680                 685             


Leu Glu Ser Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu 
    690                 695                 700                 


Asp Leu Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg 
705                 710                 715                 720 


Ala Ala Ile Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His 
                725                 730                 735     


Glu Gly Arg Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu 
            740                 745                 750         


Thr Ser Ala Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu 
        755                 760                 765             


Pro Gly Glu Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser 
    770                 775                 780                 


Met Leu Pro Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp 
785                 790                 795                 800 


Asp Ser Ser Glu Gly Ser Glu Val Leu Met 
                805                 810 


<210>  4
<211>  779
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Thr Val Ser Ser Thr Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Asp Thr Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr Gly 
                165                 170                 175     


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
            180                 185                 190         


Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
        195                 200                 205             


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr Met 
    210                 215                 220                 


Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly Gly 
                245                 250                 255     


Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala 
            340                 345                 350         


Phe Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala 
        355                 360                 365             


Ala Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu 
    370                 375                 380                 


Asp Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val 
385                 390                 395                 400 


Leu Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly 
                405                 410                 415     


Glu Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser 
            420                 425                 430         


Phe Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser 
        435                 440                 445             


Ser Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe 
    450                 455                 460                 


Asp His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg 
465                 470                 475                 480 


Ala Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys 
                485                 490                 495     


His Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn 
            500                 505                 510         


Pro Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile 
        515                 520                 525             


Ala Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp 
    530                 535                 540                 


Leu Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val 
545                 550                 555                 560 


Ala Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg 
                565                 570                 575     


Gln Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser 
            580                 585                 590         


Leu Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly 
        595                 600                 605             


Val Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly 
    610                 615                 620                 


Ile Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu 
625                 630                 635                 640 


Lys Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln 
                645                 650                 655     


Cys Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg 
            660                 665                 670         


Met Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser 
        675                 680                 685             


Gln Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala 
    690                 695                 700                 


Gly Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala 
705                 710                 715                 720 


Gly Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys 
                725                 730                 735     


Arg Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala 
            740                 745                 750         


Glu His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu 
        755                 760                 765             


Leu Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
    770                 775                 


<210>  5
<211>  761
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Thr Val Ser Ser Thr Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Asp Thr Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr Gly 
                165                 170                 175     


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
            180                 185                 190         


Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
        195                 200                 205             


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr Met 
    210                 215                 220                 


Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly Gly 
                245                 250                 255     


Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe 
            340                 345                 350         


Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg 
        355                 360                 365             


Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly 
    370                 375                 380                 


Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg 
385                 390                 395                 400 


His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala 
                405                 410                 415     


Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala 
            420                 425                 430         


Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp 
        435                 440                 445             


Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val 
    450                 455                 460                 


Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe 
465                 470                 475                 480 


Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His 
                485                 490                 495     


Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro 
            500                 505                 510         


Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu 
        515                 520                 525             


Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
    530                 535                 540                 


Cys Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu 
545                 550                 555                 560 


Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala 
                565                 570                 575     


Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val 
            580                 585                 590         


Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu 
        595                 600                 605             


Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu 
    610                 615                 620                 


Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp 
625                 630                 635                 640 


Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn 
                645                 650                 655     


Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn 
            660                 665                 670         


Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr 
        675                 680                 685             


Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala 
    690                 695                 700                 


Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser 
705                 710                 715                 720 


Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys 
                725                 730                 735     


Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro 
            740                 745                 750         


Ala Ala Pro Gly Gln Glu Asp Gly Ala 
        755                 760     


<210>  6
<211>  806
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp His Tyr Gly Asn Ser Phe Ile Tyr Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asp Ser Val Glu Thr Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Leu Gln Pro Gly Ala Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Asn Trp Trp Met His Trp Val Arg Leu Arg Pro Gly Arg Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Arg Ile Asp Pro Asn Ser Asp Val Asn Lys Tyr Asn Glu 
        195                 200                 205             


Lys Phe Glu Asn Arg Ala Ser Leu Thr Val Asp Lys His Ser Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Trp Phe Phe Pro Trp Tyr Phe Asp Val Trp Gly Thr 
                245                 250                 255     


Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Val 
                325                 330                 335     


Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu Leu 
            340                 345                 350         


Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile Glu 
        355                 360                 365             


Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys Leu 
    370                 375                 380                 


Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile Leu 
385                 390                 395                 400 


Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln Glu 
                405                 410                 415     


Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp Asn 
            420                 425                 430         


Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys Met 
        435                 440                 445             


Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys Ile 
    450                 455                 460                 


Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro Phe 
465                 470                 475                 480 


Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu Glu 
                485                 490                 495     


Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met Val 
            500                 505                 510         


Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu His 
        515                 520                 525             


Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr Val 
    530                 535                 540                 


Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp Tyr 
545                 550                 555                 560 


Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile 
                565                 570                 575     


Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ala 
            580                 585                 590         


Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro Tyr 
        595                 600                 605             


Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly His 
    610                 615                 620                 


Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile Met 
625                 630                 635                 640 


Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser Val 
                645                 650                 655     


Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val Arg 
            660                 665                 670         


Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser Ser 
        675                 680                 685             


Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn Ile 
    690                 695                 700                 


Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile Ser 
705                 710                 715                 720 


Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg Tyr 
                725                 730                 735     


Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala Pro 
            740                 745                 750         


Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu Arg 
        755                 760                 765             


Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro Leu 
    770                 775                 780                 


Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser Glu 
785                 790                 795                 800 


Gly Ser Glu Val Leu Met 
                805     


<210>  7
<211>  800
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Thr Val Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Arg Thr Asn Val Ala Trp Tyr Arg His Lys Ala Gly Gln Ala 
    50                  55                  60                  


Pro Met Ile Leu Val Ser Gly Ala Ser Thr Arg Ala Ser Gly Ala Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Tyr Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Thr Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asn Thr Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val 
    130                 135                 140                 


Gln Leu Gln His Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Asn Asp Met 
                165                 170                 175     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val Ser Thr 
            180                 185                 190         


Ile Ile Gly Ile Asp Asp Thr Thr His Tyr Ala Asp Ser Val Arg Gly 
        195                 200                 205             


Arg Phe Thr Val Ser Arg Asp Thr Ser Lys Asn Met Val Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Val Lys 
225                 230                 235                 240 


Asn Ser Gly Ile Tyr Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Val Gln Glu Thr Lys Phe Gly 
                325                 330                 335     


Asn Ala Phe Thr Glu Glu Asp Ser Glu Leu Val Val Asn Tyr Ile Ala 
            340                 345                 350         


Lys Lys Ser Phe Cys Arg Arg Ala Ile Glu Leu Thr Leu His Ser Leu 
        355                 360                 365             


Gly Val Ser Glu Glu Leu Gln Asn Lys Leu Glu Asp Val Val Ile Asp 
    370                 375                 380                 


Arg Asn Leu Leu Ile Leu Gly Lys Ile Leu Gly Glu Gly Glu Phe Gly 
385                 390                 395                 400 


Ser Val Met Glu Gly Asn Leu Lys Gln Glu Asp Gly Thr Ser Leu Lys 
                405                 410                 415     


Val Ala Val Lys Thr Met Lys Leu Asp Asn Ser Ser Gln Arg Glu Ile 
            420                 425                 430         


Glu Glu Phe Leu Ser Glu Ala Ala Cys Met Lys Asp Phe Ser His Pro 
        435                 440                 445             


Asn Val Ile Arg Leu Leu Gly Val Cys Ile Glu Met Ser Ser Gln Gly 
    450                 455                 460                 


Ile Pro Lys Pro Met Val Ile Leu Pro Phe Met Lys Tyr Gly Asp Leu 
465                 470                 475                 480 


His Thr Tyr Leu Leu Tyr Ser Arg Leu Glu Thr Gly Pro Lys His Ile 
                485                 490                 495     


Pro Leu Gln Thr Leu Leu Lys Phe Met Val Asp Ile Ala Leu Gly Met 
            500                 505                 510         


Glu Tyr Leu Ser Asn Arg Asn Phe Leu His Arg Asp Leu Ala Ala Arg 
        515                 520                 525             


Asn Cys Met Leu Arg Asp Asp Met Thr Val Cys Val Ala Asp Phe Gly 
    530                 535                 540                 


Leu Ser Lys Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln Gly Arg Ile 
545                 550                 555                 560 


Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg 
                565                 570                 575     


Val Tyr Thr Ser Lys Ser Asp Val Trp Ala Phe Gly Val Thr Met Trp 
            580                 585                 590         


Glu Ile Ala Thr Arg Gly Met Thr Pro Tyr Pro Gly Val Gln Asn His 
        595                 600                 605             


Glu Met Tyr Asp Tyr Leu Leu His Gly His Arg Leu Lys Gln Pro Glu 
    610                 615                 620                 


Asp Cys Leu Asp Glu Leu Tyr Glu Ile Met Tyr Ser Cys Trp Arg Thr 
625                 630                 635                 640 


Asp Pro Leu Asp Arg Pro Thr Phe Ser Val Leu Arg Leu Gln Leu Glu 
                645                 650                 655     


Lys Leu Leu Glu Ser Leu Pro Asp Val Arg Asn Gln Ala Asp Val Ile 
            660                 665                 670         


Tyr Val Asn Thr Gln Leu Leu Glu Ser Ser Glu Gly Leu Ala Gln Gly 
        675                 680                 685             


Ser Thr Leu Ala Pro Leu Asp Leu Asn Ile Asp Pro Asp Ser Ile Ile 
    690                 695                 700                 


Ala Ser Cys Thr Pro Arg Ala Ala Ile Ser Val Val Thr Ala Glu Val 
705                 710                 715                 720 


His Asp Ser Lys Pro His Glu Gly Arg Tyr Ile Leu Asn Gly Gly Ser 
                725                 730                 735     


Glu Glu Trp Glu Asp Leu Thr Ser Ala Pro Ser Ala Ala Val Thr Ala 
            740                 745                 750         


Glu Lys Asn Ser Val Leu Pro Gly Glu Arg Leu Val Arg Asn Gly Val 
        755                 760                 765             


Ser Trp Ser His Ser Ser Met Leu Pro Leu Gly Ser Ser Leu Pro Asp 
    770                 775                 780                 


Glu Leu Leu Phe Ala Asp Asp Ser Ser Glu Gly Ser Glu Val Leu Met 
785                 790                 795                 800 


