                         SEQUENCE LISTING

<110>  ZYMEWORKS INC.
 
<120>  FUSION PROTEINS COMPRISING A LIGAND-RECEPTOR PAIR AND A 
       BIOLOGICALLY FUNCTIONAL PROTEIN

<130>  V816961WO

<140>  PCT/CA2021/051006
<141>  2021-07-20

<150>  63/172,626
<151>  2021-04-08

<150>  63/054,180
<151>  2020-07-20

<160>  268   

<170>  PatentIn version 3.5

<210>  1
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7 CD3 VL

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
            100                 105     


<210>  2
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7 CD3 VH

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab scFv

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                165                 170                 175     


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  4
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chain A CH3 region

<400>  4

Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Ala Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  5
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChainB CH3 region

<400>  5

Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  6
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH2 region with L234A-L235A_D265S mutations

<400>  6

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  7
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild type PD-1

<400>  7

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu 
        


<210>  8
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild type PD-L1

<400>  8

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala 
        115 


<210>  9
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  High affinity PD-1

<400>  9

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu 
        


<210>  10
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  High affinity PD-L1

<400>  10

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Gln Val Phe Trp Met Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Thr 
                85                  90                  95      


Cys Leu Ile Ala Tyr Lys Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala 
        115 


<210>  11
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT CS PD-1

<400>  11

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu 
        


<210>  12
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild type CH3 region

<400>  12

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL

<400>  13

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH

<400>  14

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  15
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN VL

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  16
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN VH

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TF VL

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TF VH

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Glu Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Asp Pro Glu Gln Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Ser Ala Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Ala Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19A VL

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  20
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19A VH

<400>  20

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Ala Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cMET VL

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  22
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cMET VH

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  23
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH3 VL

<400>  23

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Ser Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Gly 
                85                  90                  95      


Leu Pro Trp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  24
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH3 VH

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Asp Gly Thr Leu Asn Pro Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT CD80

<400>  25

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala 
            100                 105     


<210>  26
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT CTLA4

<400>  26

Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile 
1               5                   10                  15      


Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val 
            20                  25                  30          


Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys 
        35                  40                  45              


Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser 
    50                  55                  60                  


Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln 
65                  70                  75                  80  


Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu 
                85                  90                  95      


Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile 
            100                 105                 110         


Tyr Val Ile Asp Pro Glu 
        115             


<210>  27
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  27

Glu Phe Ala Thr Met Arg Pro Thr Trp Ala Trp Trp Leu Phe Leu Val 
1               5                   10                  15      


Leu Leu Leu Ala Leu Trp Ala Pro Ala Arg Gly 
            20                  25          


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  28

Met Ser Gly Arg Ser Ala Asn Ala 
1               5               


<210>  29
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc sequence 231-447 (EU-numbering)

<400>  29

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  30

Thr Ser Gly Arg Ser Ala Asn Pro 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  31

Leu Ser Gly Arg Ser Asp Asn His 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  32

Gly Ser Gly Arg Ser Ala Gln Val 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  33

Gly Ser Ser Arg Asn Ala Asp Val 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  34

Gly Thr Ala Arg Ser Asp Asn Val 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage sequence

<400>  35

Gly Gly Gly Arg Val Asn Asn Val 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  36

Met Ser Ala Arg Ile Leu Gln Val 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  37

Gly Lys Gly Arg Ser Ala Asn Ala 
1               5               


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  38

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  39

Glu Ala Ala Ala Lys 
1               5   


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40

Pro Pro Pro Pro 
1               


<210>  41
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  41

Pro Pro Pro 
1           


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  42

Gly Gly Gly Gly Ser 
1               5   


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker with C-terminal protease cleavage site

<400>  43

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Met Ser Gly Arg Ser Ala 
1               5                   10                  15      


Asn Ala 
        


<210>  44
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker with N-terminal protease cleavage site

<400>  44

Met Ser Gly Arg Ser Ala Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys 
        


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker with N-terminal protease cleavage sequence

<400>  45

Met Ser Gly Arg Ser Ala Asn Ala Glu Ala Ala Ala Lys 
1               5                   10              


<210>  46
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 787 Full

<400>  46

Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Lys Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Thr Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 787, 23262, 23264 VL

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 787, 23262, 23264 LCDR1

<400>  48

Arg Ala Ser Arg Asp Ile Lys Ser Tyr Leu Asn 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 787, 23262, 23264 LCDR2

<400>  49

Tyr Ala Thr Ser Leu Ala Glu 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 787, 23262, 23264 LCDR3

<400>  50

Leu Gln His Gly Glu Ser Pro Trp Thr 
1               5                   


<210>  51
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 1380 Full

<400>  51

Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu 
            180                 185                 190         


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  52
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 2932 Full

<400>  52

Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Glu 
            20                  25                  30          


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Leu Ile Asp Pro Glu Gln Gly Asn Thr Ile Tyr Asp Pro Lys 
    50                  55                  60                  


Phe Gln Asp Arg Ala Thr Ile Ser Ala Asp Asn Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Thr Ala Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  53
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 2932, 23261 VH

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Glu Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Asp Pro Glu Gln Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Ser Ala Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Ala Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 2932, 23261 HCDR1

<400>  54

Glu Tyr Tyr Met His 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 2932, 23261 HCDR2

<400>  55

Leu Ile Asp Pro Glu Gln Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 2932, 23261 HCDR3

<400>  56

Asp Thr Ala Ala Tyr Phe Asp Tyr 
1               5               


<210>  57
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3232, 3357 Full

<400>  57

Gly Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro 
1               5                   10                  15      


Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr 
            20                  25                  30          


Asn Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu 
65                  70                  75                  80  


Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro 
                85                  90                  95      


Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  58
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3232, 3357, 23247, 23248 VL

<400>  58

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3232, 3357, 23247, 23248 LCDR1

<400>  59

Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3232, 3357, 23247, 23248 LCDR2

<400>  60

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3232,3357, 23247, 23248 LCDR3

<400>  61

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  62
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3345 Full

<400>  62

Gly Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr 
1               5                   10                  15      


Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr 
            20                  25                  30          


Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu 
        35                  40                  45              


Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro 
    50                  55                  60                  


Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Ala Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  63
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3345, 23257 VH

<400>  63

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Ala Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3345, 23257 HCDR1

<400>  64

Thr Ser Gly Met Gly Val Gly 
1               5           


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3345, 23257 HCDR2

<400>  65

His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 3345, 23257 HCDR3

<400>  66

Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  67
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10564 Full

<400>  67

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly 
            20                  25                  30          


Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Arg Gly Lys Ala Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  68
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10564, 23253 VH

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10564, 23253 HCDR1

<400>  69

Gly Tyr Thr Met Asn 
1               5   


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10564, 23253 HCDR2

<400>  70

Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10564, 23253 HCDR3

<400>  71

Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr 
1               5                   10  


<210>  72
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10565 Full

<400>  72

Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            20                  25                  30          


Met His Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  73
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10565, 23256 VL

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10565, 23256, 23258, 23260 LCDR1

<400>  74

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10565, 23256, 23258, 23260 LCDR2

<400>  75

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10565, 23256 LCDR3

<400>  76

Gln Gln Trp Ser Lys His Pro Leu Thr 
1               5                   


<210>  77
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10567 Full

<400>  77

Gly Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ala 
            20                  25                  30          


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Met Ile Ser Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser 
                85                  90                  95      


Gly Leu Pro Trp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  78
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10567, 20871 VL

<400>  78

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Ser Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Gly 
                85                  90                  95      


Leu Pro Trp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10567, 20871 LCDR1

<400>  79

Thr Gly Thr Ser Asn Asp Val Gly Ala Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10567, 20871 LCDR2

<400>  80

Glu Val Asn Lys Arg Pro Ser 
1               5           


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10567, 20871 LCDR3

<400>  81

Ser Ser Phe Thr Ser Gly Leu Pro Trp Val Val 
1               5                   10      


<210>  82
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10606 Full

<400>  82

Gly Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn 
            20                  25                  30          


Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe 
    50                  55                  60                  


Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe 
65                  70                  75                  80  


Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  83
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10606, 23246, 23567 VH

<400>  83

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10606, 23246, 23567 HCDR1

<400>  84

Asn Tyr Gly Val His 
1               5   


<210>  85
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10606, 23246, 23567 HCDR2

<400>  85

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
1               5                   10                  15      


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 10606, 23246, 23567 HCDR3

<400>  86

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
1               5                   10      


<210>  87
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11274 Full

<400>  87

Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Trp Gly Asp Gly Thr Leu Asn Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  88
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11274, 20875 VH

<400>  88

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Asp Gly Thr Leu Asn Pro Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11274, 20875 HCDR1

<400>  89

Ser Tyr Ala Met Ser 
1               5   


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11274, 20875 HCDR2

<400>  90

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11274, 20875 HCDR3

<400>  91

Trp Gly Asp Gly Thr Leu Asn Pro 
1               5               


<210>  92
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11462 Full

<400>  92

Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser 
            20                  25                  30          


Tyr Ala Asn Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser 
                85                  90                  95      


Lys Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  93
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11462, 20855 VL

<400>  93

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11462, 20855 LCDR1

<400>  94

Lys Ser Ser Glu Ser Val Asp Ser Tyr Ala Asn Ser Phe Leu His 
1               5                   10                  15  


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11462, 20855 LCDR2

<400>  95

Arg Ala Ser Thr Arg Glu Ser 
1               5           


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11462, 20855 LCDR3

<400>  96

Gln Gln Ser Lys Glu Asp Pro Leu Thr 
1               5                   


<210>  97
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11509 Full

<400>  97

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala 
            20                  25                  30          


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Cys 
    210                 215                 220                 


His Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  98
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11509, 20859 VH

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11509, 20859 HCDR1

<400>  99

Ala Tyr Thr Met His 
1               5   


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11509, 20859 HCDR2

<400>  100

Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11509, 20859 HCDR3

<400>  101

Ser Glu Ile Thr Thr Glu Phe Asp Tyr 
1               5                   


<210>  102
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12985 Full

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  103
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12985, 22091, 22092, 22094, 22105 VL

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
            100                 105     


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12985, 22091, 22092, 22094, 22105 LCDR1

<400>  104

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12985, 22091, 22092, 22094, 22105 LCDR2

<400>  105

Asp Ser Ser Lys Leu Ala Ser 
1               5           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12985, 22091, 22092, 22094, 22105 LCDR3

<400>  106

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  107
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12989 Full

<400>  107

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  108
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12989, 22080, 22082, 22083, 22086, 22088, 24659, 24660, 
       24661 VH

<400>  108

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12989, 22080, 22082, 22083, 22086, 22088, 24659, 24660, 
       24661 HCDR1

<400>  109

Arg Ser Thr Met His 
1               5   


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12989, 22080, 22082, 22083, 22086, 22088, 24659, 24660, 
       24661 HCDR2

<400>  110

Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  111
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 12989, 22080, 22082, 22083, 22086, 22088, 24659, 24660, 
       24661 HCDR3

<400>  111

Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10          


<210>  112
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 20855 Full

<400>  112

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ile Val 
        115                 120                 125             


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
    130                 135                 140                 


Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr Ala Asn Ser 
145                 150                 155                 160 


Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
        195                 200                 205             


Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys Glu Asp Pro 
    210                 215                 220                 


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
225                 230                 235                 240 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                245                 250                 255     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            260                 265                 270         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        275                 280                 285             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    290                 295                 300                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
305                 310                 315                 320 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                325                 330                 335     


Ser Phe Asn Arg Gly Glu Cys 
            340             


<210>  113
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 20855, 20871, 22091, 22094, 23247, 23248, 23256, 23258, 
       23260, 23262, 23264, 23715, 23716 Mask

<400>  113

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala 
        115 


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 20855, 20859, 20871, 20875, 22080, 22082, 22088, 22091, 
       22092, 23246, 23247, 23253, 23257, 23258, 23261, 23262, 23714, 
       23715, 24659, 24660, 24661 Mask Linker

<400>  114

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  115
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 20859 Full

<400>  115

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala Tyr Thr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Lys 
                165                 170                 175     


Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
            180                 185                 190         


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
        195                 200                 205             


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Glu 
    210                 215                 220                 


Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                245                 250                 255     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            260                 265                 270         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        275                 280                 285             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    290                 295                 300                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
305                 310                 315                 320 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                325                 330                 335     


Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Cys His Cys Pro Pro Cys 
            340                 345                 350         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        355                 360                 365             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    370                 375                 380                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
385                 390                 395                 400 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                405                 410                 415     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            420                 425                 430         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        435                 440                 445             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    450                 455                 460                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
465                 470                 475                 480 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                485                 490                 495     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            500                 505                 510         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        515                 520                 525             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    530                 535                 540                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
545                 550                 555                 560 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 


<210>  116
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 20859, 20875, 22080, 23246, 23253, 23257, 23261, 23714 
       Mask

<400>  116

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu 
        


<210>  117
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 20871 Full

<400>  117

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Ser Ala 
        115                 120                 125             


Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr 
    130                 135                 140                 


Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ala Tyr Asn Tyr Val 
145                 150                 155                 160 


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Ser 
                165                 170                 175     


Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser 
            180                 185                 190         


Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu 
        195                 200                 205             


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Gly Leu Pro Trp 
    210                 215                 220                 


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
225                 230                 235                 240 


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
                245                 250                 255     


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
            260                 265                 270         


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
        275                 280                 285             


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
    290                 295                 300                 


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
305                 310                 315                 320 


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
                325                 330                 335     


Ala Pro Thr Glu Cys Ser 
            340         


<210>  118
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 20875 Full

<400>  118

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Val Gln Leu 
        115                 120                 125             


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser 
                165                 170                 175     


Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Trp Gly 
    210                 215                 220                 


Asp Gly Thr Leu Asn Pro Trp Gly Gln Gly Thr Met Val Thr Val Ser 
225                 230                 235                 240 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                245                 250                 255     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            260                 265                 270         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        275                 280                 285             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    290                 295                 300                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
305                 310                 315                 320 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                325                 330                 335     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        355                 360                 365             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    370                 375                 380                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
385                 390                 395                 400 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                405                 410                 415     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            420                 425                 430         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        435                 440                 445             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    450                 455                 460                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
465                 470                 475                 480 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                485                 490                 495     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            500                 505                 510         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        515                 520                 525             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    530                 535                 540                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
545                 550                 555                 560 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570 


<210>  119
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 Full

<400>  119

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                165                 170                 175     


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475             


<210>  120
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 VH

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 HCDR1

<400>  121

Asp Thr Tyr Ile His 
1               5   


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 HCDR2

<400>  122

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 HCDR3

<400>  123

Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 VL

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 LCDR1

<400>  125

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 LCDR2

<400>  126

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21490 LCDR3

<400>  127

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  128
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 Full

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Tyr Glu Gly Arg Ser Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Glu Gly Met Asp Phe Asp Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Glu 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Pro 
            180                 185                 190         


Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Pro Pro 
    210                 215                 220                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                245                 250                 255     


Val Val Val Ala Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
305                 310                 315                 320 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Arg Pro Lys Ala Pro Gln Val Tyr Val Ile Pro Pro Ser Lys Glu Gln 
            340                 345                 350         


Met Ala Lys Asp Lys Val Ser Leu Leu Cys Met Ile Thr Asp Phe Phe 
        355                 360                 365             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    370                 375                 380                 


Asn Tyr Leu Thr Trp Pro Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                405                 410                 415     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Glu Lys Ser Leu Ser His Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Ile Val Met 
    450                 455                 460                 


Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly Gly Thr Val Thr 
465                 470                 475                 480 


Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Ser Ser Leu Ala Trp Tyr 
                485                 490                 495     


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            500                 505                 510         


His Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Tyr Gly 
        515                 520                 525             


Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala 
    530                 535                 540                 


Thr Tyr Tyr Cys Gln Gly Gly Trp Tyr Ser Ser Ala Ala Thr Tyr Val 
545                 550                 555                 560 


Pro Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Glu Gln Leu 
            580                 585                 590         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser Leu Thr Leu 
        595                 600                 605             


Thr Cys Lys Ala Ser Gly Phe Thr Ile Ser Asn Asn Tyr Tyr Met Cys 
    610                 615                 620                 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile 
625                 630                 635                 640 


Tyr Gly Gly Ile Ser Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
                645                 650                 655     


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln Met 
            660                 665                 670         


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Val Arg Gly 
        675                 680                 685             


Tyr Val Gly Thr Ser Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val 
    690                 695                 700                 


Ser Ser 
705     


<210>  129
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 VH

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Tyr Glu Gly Arg Ser Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Glu Gly Met Asp Phe Asp Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 HCDR1

<400>  130

Asp Tyr Tyr Met Ala 
1               5   


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 HCDR2

<400>  131

Ser Ile Ser Tyr Glu Gly Arg Ser Thr Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 HCDR3

<400>  132

Arg Ala Glu Gly Met Asp Phe Asp Tyr 
1               5                   


<210>  133
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 VH

<400>  133

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Thr Ile Ser Asn Asn 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Gly Gly Ile Ser Gly Arg Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Val Arg Gly Tyr Val Gly Thr Ser Asn Leu Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  134
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 HCDR1

<400>  134

Asn Asn Tyr Tyr Met Cys 
1               5       


<210>  135
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 HCDR2

<400>  135

Cys Ile Tyr Gly Gly Ile Ser Gly Arg Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 HCDR3

<400>  136

Gly Tyr Val Gly Thr Ser Asn Leu 
1               5               


<210>  137
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 VL

<400>  137

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser His Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Tyr Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly Trp Tyr Ser Ser Ala 
                85                  90                  95      


Ala Thr Tyr Val Pro Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 LCDR1

<400>  138

Gln Ala Ser Gln Ser Ile Tyr Ser Ser Leu Ala 
1               5                   10      


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 LCDR2

<400>  139

Asp Ala Ser His Leu Ala Ser 
1               5           


<210>  140
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21496 LCDR3

<400>  140

Gln Gly Gly Trp Tyr Ser Ser Ala Ala Thr Tyr Val Pro Asn Thr 
1               5                   10                  15  


<210>  141
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22080 Full

<400>  141

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
                165                 170                 175     


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp 
        195                 200                 205             


Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln 
    210                 215                 220                 


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                245                 250                 255     


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
            260                 265                 270         


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
        275                 280                 285             


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
    290                 295                 300                 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
305                 310                 315                 320 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                325                 330                 335     


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
            340                 345                 350         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
        355                 360                 365             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    370                 375                 380                 


Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu Asp Pro Glu 
385                 390                 395                 400 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                405                 410                 415     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            420                 425                 430         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        435                 440                 445             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    450                 455                 460                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro 
465                 470                 475                 480 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                485                 490                 495     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            500                 505                 510         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        515                 520                 525             


Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
    530                 535                 540                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
545                 550                 555                 560 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 


<210>  142
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22082 Full

<400>  142

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
                165                 170                 175     


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp 
        195                 200                 205             


Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln 
    210                 215                 220                 


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                245                 250                 255     


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
            260                 265                 270         


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
        275                 280                 285             


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
    290                 295                 300                 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
305                 310                 315                 320 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                325                 330                 335     


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
            340                 345                 350         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
        355                 360                 365             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    370                 375                 380                 


Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu Asp Pro Glu 
385                 390                 395                 400 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                405                 410                 415     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            420                 425                 430         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        435                 440                 445             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    450                 455                 460                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro 
465                 470                 475                 480 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                485                 490                 495     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            500                 505                 510         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        515                 520                 525             


Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
    530                 535                 540                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
545                 550                 555                 560 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 


<210>  143
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22082, 22083, 22086 Mask

<400>  143

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu 
        


<210>  144
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22083 Full

<400>  144

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Met Ser Gly Arg Ser Ala Asn Ala Glu Ala Ala Ala Lys Gln 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
        195                 200                 205             


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            260                 265                 270         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        275                 280                 285             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    290                 295                 300                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
305                 310                 315                 320 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                325                 330                 335     


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
            340                 345                 350         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
        355                 360                 365             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    370                 375                 380                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu 
385                 390                 395                 400 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                405                 410                 415     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            420                 425                 430         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        435                 440                 445             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    450                 455                 460                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
465                 470                 475                 480 


Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                485                 490                 495     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            500                 505                 510         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        515                 520                 525             


Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp 
    530                 535                 540                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
545                 550                 555                 560 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                565                 570                 575     


Gly 
    


<210>  145
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22083 Mask Linker

<400>  145

Met Ser Gly Arg Ser Ala Asn Ala Glu Ala Ala Ala Lys 
1               5                   10              


<210>  146
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22086 Full

<400>  146

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Met Ser Gly Arg 
        115                 120                 125             


Ser Ala Asn Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
            180                 185                 190         


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
        195                 200                 205             


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
225                 230                 235                 240 


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    450                 455                 460                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser 
    530                 535                 540                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Pro Gly 
            580         


<210>  147
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22086, 22105, 23248, 23256, 23260, 23264, 23716 Mask 
       Linker

<400>  147

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Met Ser Gly Arg Ser Ala 
1               5                   10                  15      


Asn Ala 
        


<210>  148
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22088 Full

<400>  148

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Glu Ala Ala Ala Lys Glu 
            100                 105                 110         


Ala Ala Ala Lys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
        115                 120                 125             


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
    130                 135                 140                 


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
145                 150                 155                 160 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
                165                 170                 175     


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
            180                 185                 190         


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
        195                 200                 205             


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
    210                 215                 220                 


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr 
225                 230                 235                 240 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                245                 250                 255     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            260                 265                 270         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        275                 280                 285             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
305                 310                 315                 320 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                325                 330                 335     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            340                 345                 350         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        355                 360                 365             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    370                 375                 380                 


Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
385                 390                 395                 400 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                405                 410                 415     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            420                 425                 430         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        435                 440                 445             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    450                 455                 460                 


Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys 
465                 470                 475                 480 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                485                 490                 495     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            500                 505                 510         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser 
        515                 520                 525             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    530                 535                 540                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
545                 550                 555                 560 


Leu Ser Leu Ser Pro Gly 
                565     


<210>  149
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22088 Mask

<400>  149

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala 
            100                 105     


<210>  150
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22091 Full

<400>  150

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ile Gln 
        115                 120                 125             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    130                 135                 140                 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
                165                 170                 175     


Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
        195                 200                 205             


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
    210                 215                 220                 


Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
                245                 250                 255     


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
            260                 265                 270         


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
        275                 280                 285             


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
    290                 295                 300                 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
305                 310                 315                 320 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
                325                 330                 335     


Glu Cys 
        


<210>  151
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22092 Full

<400>  151

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Gln Val Phe Trp Met Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Thr 
                85                  90                  95      


Cys Leu Ile Ala Tyr Lys Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ile Gln 
        115                 120                 125             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    130                 135                 140                 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
                165                 170                 175     


Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
        195                 200                 205             


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
    210                 215                 220                 


Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
                245                 250                 255     


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
            260                 265                 270         


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
        275                 280                 285             


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
    290                 295                 300                 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
305                 310                 315                 320 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
                325                 330                 335     


Glu Cys 
        


<210>  152
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22092 Mask

<400>  152

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Gln Val Phe Trp Met Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Thr 
                85                  90                  95      


Cys Leu Ile Ala Tyr Lys Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala 
        115 


<210>  153
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22094 Full

<400>  153

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Met Ser Gly Arg Ser Ala Asn Ala 
        115                 120                 125             


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
    130                 135                 140                 


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
                165                 170                 175     


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        195                 200                 205             


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                245                 250                 255     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            260                 265                 270         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        275                 280                 285             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
305                 310                 315                 320 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                325                 330                 335     


Asn Arg Gly Glu Cys 
            340     


<210>  154
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22094 Mask Linker

<400>  154

Glu Ala Ala Ala Lys Met Ser Gly Arg Ser Ala Asn Ala 
1               5                   10              


<210>  155
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22105 Full

<400>  155

Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile 
1               5                   10                  15      


Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val 
            20                  25                  30          


Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys 
        35                  40                  45              


Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser 
    50                  55                  60                  


Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln 
65                  70                  75                  80  


Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu 
                85                  90                  95      


Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile 
            100                 105                 110         


Tyr Val Ile Asp Pro Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
        115                 120                 125             


Met Ser Gly Arg Ser Ala Asn Ala Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln 
225                 230                 235                 240 


Ile Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
                245                 250                 255     


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
            260                 265                 270         


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
        275                 280                 285             


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
    290                 295                 300                 


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
305                 310                 315                 320 


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
                325                 330                 335     


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345                 


<210>  156
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 22105 Mask

<400>  156

Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile 
1               5                   10                  15      


Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val 
            20                  25                  30          


Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys 
        35                  40                  45              


Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser 
    50                  55                  60                  


Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln 
65                  70                  75                  80  


Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu 
                85                  90                  95      


Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile 
            100                 105                 110         


Tyr Val Ile Asp Pro Glu 
        115             


<210>  157
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23246 Full

<400>  157

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Gln Leu 
        115                 120                 125             


Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Ile 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp 
145                 150                 155                 160 


Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
                165                 170                 175     


Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Leu Ser 
            180                 185                 190         


Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe Lys Met Asn Ser 
        195                 200                 205             


Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr 
    210                 215                 220                 


Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                245                 250                 255     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            260                 265                 270         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        275                 280                 285             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    290                 295                 300                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
305                 310                 315                 320 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                325                 330                 335     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            340                 345                 350         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        355                 360                 365             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    370                 375                 380                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
385                 390                 395                 400 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                405                 410                 415     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            420                 425                 430         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        435                 440                 445             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    450                 455                 460                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
465                 470                 475                 480 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                485                 490                 495     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            500                 505                 510         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        515                 520                 525             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    530                 535                 540                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
545                 550                 555                 560 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570         


<210>  158
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23247 Full

<400>  158

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ile Leu 
        115                 120                 125             


Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val 
    130                 135                 140                 


Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp 
145                 150                 155                 160 


Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala 
                165                 170                 175     


Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile 
        195                 200                 205             


Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                245                 250                 255     


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            260                 265                 270         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        275                 280                 285             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    290                 295                 300                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
305                 310                 315                 320 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                325                 330                 335     


Gly Glu Cys 
            


<210>  159
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23248 Full

<400>  159

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Met Ser Gly 
        115                 120                 125             


Arg Ser Ala Asn Ala Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser 
                165                 170                 175     


Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile 
        195                 200                 205             


Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn 
    210                 215                 220                 


Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
225                 230                 235                 240 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                245                 250                 255     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            260                 265                 270         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        275                 280                 285             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    290                 295                 300                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
305                 310                 315                 320 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                325                 330                 335     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345         


<210>  160
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23253 Full

<400>  160

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Leu Ile Thr 
                165                 170                 175     


Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala 
            180                 185                 190         


Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
        195                 200                 205             


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly 
    210                 215                 220                 


Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                245                 250                 255     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            260                 265                 270         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        275                 280                 285             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    290                 295                 300                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
305                 310                 315                 320 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                325                 330                 335     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            340                 345                 350         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        355                 360                 365             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    370                 375                 380                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
385                 390                 395                 400 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                405                 410                 415     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            420                 425                 430         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        435                 440                 445             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    450                 455                 460                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
465                 470                 475                 480 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                485                 490                 495     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            500                 505                 510         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        515                 520                 525             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    530                 535                 540                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
545                 550                 555                 560 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570         


<210>  161
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23256 Full

<400>  161

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Met Ser Gly 
        115                 120                 125             


Arg Ser Ala Asn Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
    210                 215                 220                 


Lys His Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235                 240 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
                245                 250                 255     


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            260                 265                 270         


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        275                 280                 285             


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    290                 295                 300                 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
305                 310                 315                 320 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                325                 330                 335     


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345     


<210>  162
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23257 Full

<400>  162

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Thr Leu 
        115                 120                 125             


Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu 
    130                 135                 140                 


Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val 
145                 150                 155                 160 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala His 
                165                 170                 175     


Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg 
            180                 185                 190         


Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met 
        195                 200                 205             


Thr Asn Met Asp Pro Val Asp Thr Ala Ala Tyr Tyr Cys Ala Arg Met 
    210                 215                 220                 


Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                245                 250                 255     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            260                 265                 270         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        275                 280                 285             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    290                 295                 300                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
305                 310                 315                 320 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                325                 330                 335     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            340                 345                 350         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
        355                 360                 365             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    370                 375                 380                 


Glu Val Thr Cys Val Val Val Ser Val Ser His Glu Asp Pro Glu Val 
385                 390                 395                 400 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                405                 410                 415     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            420                 425                 430         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        435                 440                 445             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    450                 455                 460                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
465                 470                 475                 480 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                485                 490                 495     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            500                 505                 510         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        515                 520                 525             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    530                 535                 540                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
545                 550                 555                 560 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570             


<210>  163
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23258 Full

<400>  163

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ile Val 
        115                 120                 125             


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
    130                 135                 140                 


Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser 
                165                 170                 175     


Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
        195                 200                 205             


Val Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr Phe Gly Gln 
    210                 215                 220                 


Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
                245                 250                 255     


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
            260                 265                 270         


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
        275                 280                 285             


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
    290                 295                 300                 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
305                 310                 315                 320 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
                325                 330                 335     


Glu Cys 
        


<210>  164
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23258, 23260 VL

<400>  164

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23258, 23260 LCDR3

<400>  165

Phe Gln Gly Ser Val Tyr Pro Phe Thr 
1               5                   


<210>  166
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23260 Full

<400>  166

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Met Ser Gly 
        115                 120                 125             


Arg Ser Ala Asn Ala Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Arg Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser 
    210                 215                 220                 


Val Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235                 240 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
                245                 250                 255     


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            260                 265                 270         


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        275                 280                 285             


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    290                 295                 300                 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
305                 310                 315                 320 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                325                 330                 335     


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345     


<210>  167
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23261 Full

<400>  167

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Glu Tyr Tyr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Leu Ile Asp 
                165                 170                 175     


Pro Glu Gln Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln Asp Arg Ala 
            180                 185                 190         


Thr Ile Ser Ala Asp Asn Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Thr 
    210                 215                 220                 


Ala Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                245                 250                 255     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            260                 265                 270         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        275                 280                 285             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    290                 295                 300                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
305                 310                 315                 320 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                325                 330                 335     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        355                 360                 365             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    370                 375                 380                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
385                 390                 395                 400 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                405                 410                 415     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            420                 425                 430         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        435                 440                 445             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    450                 455                 460                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
465                 470                 475                 480 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                485                 490                 495     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            500                 505                 510         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        515                 520                 525             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    530                 535                 540                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
545                 550                 555                 560 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570 


<210>  168
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23262 Full

<400>  168

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ile Gln 
        115                 120                 125             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    130                 135                 140                 


Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Lys Ser Tyr Leu Asn Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile Tyr Tyr Ala 
                165                 170                 175     


Thr Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Trp Thr Phe Gly 
    210                 215                 220                 


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                245                 250                 255     


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            260                 265                 270         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        275                 280                 285             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    290                 295                 300                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
305                 310                 315                 320 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                325                 330                 335     


Gly Glu Cys 
            


<210>  169
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23264 Full

<400>  169

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Met Ser Gly 
        115                 120                 125             


Arg Ser Ala Asn Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg 
145                 150                 155                 160 


Asp Ile Lys Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Val Leu Ile Tyr Tyr Ala Thr Ser Leu Ala Glu Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His 
    210                 215                 220                 


Gly Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                245                 250                 255     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            260                 265                 270         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        275                 280                 285             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    290                 295                 300                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
305                 310                 315                 320 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                325                 330                 335     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345         


<210>  170
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23567 Full

<400>  170

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  171
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23712 Full

<400>  171

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  172
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23712, 23714 VH

<400>  172

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  173
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23712, 23714 HCDR1

<400>  173

Gly Tyr Tyr Met His 
1               5   


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23712, 23714 HCDR2

<400>  174

Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23712, 23714 HCDR3

<400>  175

Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  176
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23713 Full

<400>  176

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  177
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23713, 23715, 23716 VL

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  178
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23713, 23715, 23716 LCDR1

<400>  178

Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala 
1               5                   10      


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23713, 23715, 23716 LCDR2

<400>  179

Thr Ala Ser Thr Leu Gln Ser 
1               5           


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23713, 23715, 23716 LCDR3

<400>  180

Gln Gln Ala Asn Ile Phe Pro Leu Thr 
1               5                   


<210>  181
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23714 Full

<400>  181

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn 
                165                 170                 175     


Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
            180                 185                 190         


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn 
        195                 200                 205             


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln 
    210                 215                 220                 


Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
                245                 250                 255     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            260                 265                 270         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        275                 280                 285             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    290                 295                 300                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
305                 310                 315                 320 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                325                 330                 335     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            340                 345                 350         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        355                 360                 365             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    370                 375                 380                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
385                 390                 395                 400 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                405                 410                 415     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            420                 425                 430         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        435                 440                 445             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    450                 455                 460                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
465                 470                 475                 480 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                485                 490                 495     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            500                 505                 510         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        515                 520                 525             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    530                 535                 540                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
545                 550                 555                 560 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                565                 570                 575     


Ser Pro Gly 
            


<210>  182
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23715 Full

<400>  182

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ile Gln 
        115                 120                 125             


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
    130                 135                 140                 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
                165                 170                 175     


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
    210                 215                 220                 


Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                245                 250                 255     


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            260                 265                 270         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        275                 280                 285             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    290                 295                 300                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
305                 310                 315                 320 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                325                 330                 335     


Gly Glu Cys 
            


<210>  183
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23716 Full

<400>  183

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Met Ser Gly 
        115                 120                 125             


Arg Ser Ala Asn Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Gly Ile Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Asn Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 
    210                 215                 220                 


Asn Ile Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                245                 250                 255     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            260                 265                 270         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        275                 280                 285             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    290                 295                 300                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
305                 310                 315                 320 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                325                 330                 335     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345         


<210>  184
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24659 Full

<400>  184

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ser Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ser Ile Ser Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Glu Ala Ala Ala Lys Glu 
            100                 105                 110         


Ala Ala Ala Lys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
        115                 120                 125             


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
    130                 135                 140                 


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
145                 150                 155                 160 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
                165                 170                 175     


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
            180                 185                 190         


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
        195                 200                 205             


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
    210                 215                 220                 


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr 
225                 230                 235                 240 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                245                 250                 255     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            260                 265                 270         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        275                 280                 285             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
305                 310                 315                 320 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                325                 330                 335     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            340                 345                 350         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        355                 360                 365             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    370                 375                 380                 


Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
385                 390                 395                 400 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                405                 410                 415     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            420                 425                 430         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        435                 440                 445             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    450                 455                 460                 


Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys 
465                 470                 475                 480 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                485                 490                 495     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            500                 505                 510         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser 
        515                 520                 525             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    530                 535                 540                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
545                 550                 555                 560 


Leu Ser Leu Ser Pro Gly 
                565     


<210>  185
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24659 Mask

<400>  185

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ser Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ser Ile Ser Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala 
            100                 105     


<210>  186
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24660 Full

<400>  186

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ser Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ser Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Glu Ala Ala Ala Lys Glu 
            100                 105                 110         


Ala Ala Ala Lys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
        115                 120                 125             


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
    130                 135                 140                 


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
145                 150                 155                 160 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
                165                 170                 175     


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
            180                 185                 190         


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
        195                 200                 205             


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
    210                 215                 220                 


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr 
225                 230                 235                 240 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                245                 250                 255     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            260                 265                 270         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        275                 280                 285             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
305                 310                 315                 320 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                325                 330                 335     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            340                 345                 350         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        355                 360                 365             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    370                 375                 380                 


Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
385                 390                 395                 400 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                405                 410                 415     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            420                 425                 430         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        435                 440                 445             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    450                 455                 460                 


Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys 
465                 470                 475                 480 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                485                 490                 495     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            500                 505                 510         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser 
        515                 520                 525             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    530                 535                 540                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
545                 550                 555                 560 


Leu Ser Leu Ser Pro Gly 
                565     


<210>  187
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24660 Mask

<400>  187

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ser Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ser Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala 
            100                 105     


<210>  188
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24661 Full

<400>  188

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ser Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Glu Ala Ala Ala Lys Glu 
            100                 105                 110         


Ala Ala Ala Lys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
        115                 120                 125             


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
    130                 135                 140                 


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
145                 150                 155                 160 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
                165                 170                 175     


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
            180                 185                 190         


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
        195                 200                 205             


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
    210                 215                 220                 


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr 
225                 230                 235                 240 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                245                 250                 255     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            260                 265                 270         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        275                 280                 285             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
305                 310                 315                 320 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                325                 330                 335     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            340                 345                 350         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        355                 360                 365             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    370                 375                 380                 


Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
385                 390                 395                 400 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                405                 410                 415     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            420                 425                 430         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        435                 440                 445             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    450                 455                 460                 


Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys 
465                 470                 475                 480 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                485                 490                 495     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            500                 505                 510         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser 
        515                 520                 525             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    530                 535                 540                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
545                 550                 555                 560 


Leu Ser Leu Ser Pro Gly 
                565     


<210>  189
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24661 Mask

<400>  189

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ser Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala 
            100                 105     


<210>  190
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23734

<400>  190

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Ala Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ala Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
                165                 170                 175     


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp 
        195                 200                 205             


Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln 
    210                 215                 220                 


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                245                 250                 255     


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
            260                 265                 270         


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
        275                 280                 285             


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
    290                 295                 300                 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
305                 310                 315                 320 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                325                 330                 335     


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
            340                 345                 350         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
        355                 360                 365             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    370                 375                 380                 


Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu Asp Pro Glu 
385                 390                 395                 400 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                405                 410                 415     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            420                 425                 430         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        435                 440                 445             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    450                 455                 460                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro 
465                 470                 475                 480 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                485                 490                 495     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            500                 505                 510         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        515                 520                 525             


Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
    530                 535                 540                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
545                 550                 555                 560 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 


<210>  191
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23734 Mask

<400>  191

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Ala Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ala Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu 
        


<210>  192
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018Full

<400>  192

Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Arg Val Ser Cys Arg Ala Ser Gly Tyr Ile Phe Thr Glu 
            20                  25                  30          


Ser Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Trp Ile Ser Gly Tyr Ser Gly Asp Thr Lys Tyr Ala Gln Lys 
    50                  55                  60                  


Leu Gln Gly Arg Val Thr Met Thr Lys Asp Thr Ser Thr Thr Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Arg Ser Leu Arg Tyr Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Gln Tyr Ser Gly Ser Tyr Leu Gly Ala Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Ser Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
145                 150                 155                 160 


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 
                165                 170                 175     


Tyr Val Tyr Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
            180                 185                 190         


Ile Tyr Arg Ser Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
    210                 215                 220                 


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
225                 230                 235                 240 


Asp Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala 
                245                 250                 255     


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Leu Thr Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly 
                485         


<210>  193
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018 VH

<400>  193

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Arg Ala Ser Gly Tyr Ile Phe Thr Glu Ser 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Ser Gly Asp Thr Lys Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Lys Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Tyr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Gln Tyr Ser Gly Ser Tyr Leu Gly Ala Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Ser Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  194
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018 VL

<400>  194

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ser Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asp Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  195
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018 HCDR1

<400>  195

Glu Ser Gly Ile Thr 
1               5   


<210>  196
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018 HCDR2

<400>  196

Trp Ile Ser Gly Tyr Ser Gly Asp Thr Lys Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  197
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018 HCDR3

<400>  197

Asp Val Gln Tyr Ser Gly Ser Tyr Leu Gly Ala Tyr Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  198
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018 LCDR1

<400>  198

Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Tyr Val Tyr 
1               5                   10              


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018 LCDR2

<400>  199

Arg Ser Tyr Gln Arg Pro Ser 
1               5           


<210>  200
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11018 LCDR3

<400>  200

Ala Thr Trp Asp Asp Ser Leu Asp Gly Trp Val 
1               5                   10      


<210>  201
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25321 Full

<400>  201

Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Thr Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Met Ser Gly Arg Ser Ala Asn Ala Gln Val Gln Leu Lys 
        115                 120                 125             


Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr 
    130                 135                 140                 


Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val 
145                 150                 155                 160 


Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser 
                165                 170                 175     


Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile 
            180                 185                 190         


Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu 
        195                 200                 205             


Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr 
    210                 215                 220                 


Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                245                 250                 255     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            260                 265                 270         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        275                 280                 285             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    290                 295                 300                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
305                 310                 315                 320 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                325                 330                 335     


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            340                 345                 350         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        355                 360                 365             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    370                 375                 380                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
385                 390                 395                 400 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                405                 410                 415     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            420                 425                 430         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        435                 440                 445             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    450                 455                 460                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
465                 470                 475                 480 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                485                 490                 495     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            500                 505                 510         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        515                 520                 525             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    530                 535                 540                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
545                 550                 555                 560 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570     


<210>  202
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25321 Mask

<400>  202

Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Thr Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala 
        115 


<210>  203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25321 Mask Linker

<400>  203

Met Ser Gly Arg Ser Ala Asn Ala 
1               5               


<210>  204
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25325 Full

<400>  204

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Gly Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Met Ser Gly Arg Ser Ala Asn Ala Asp Ile Leu Leu Thr 
        115                 120                 125             


Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe 
    130                 135                 140                 


Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln 
145                 150                 155                 160 


Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu 
                165                 170                 175     


Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp 
        195                 200                 205             


Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly 
    210                 215                 220                 


Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                245                 250                 255     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            260                 265                 270         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        275                 280                 285             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    290                 295                 300                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
305                 310                 315                 320 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                325                 330                 335     


Cys 
    


<210>  205
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25325 Mask

<400>  205

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Gly Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val 
        115 


<210>  206
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 1 VH

<400>  206

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asn Tyr Tyr 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Ser Gly Gly Arg Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Thr Gln Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Asp Gly Arg Asp Gly Trp Val Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  207
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 1 Kabat HCDR1

<400>  207

Tyr Tyr Gly Met Ser 
1               5   


<210>  208
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 1 Kabat HCDR2

<400>  208

Ser Ile Thr Ser Ser Gly Gly Arg Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 1 Kabat HCDR3

<400>  209

Asp Gly Arg Asp Gly Trp Val Ala Tyr 
1               5                   


<210>  210
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 1 VL

<400>  210

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Lys Arg Asn Thr Gly Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln His Glu Gly Ser Ser Pro Thr Thr Ile 
        35                  40                  45              


Ile Tyr Arg Asn Asp Lys Arg Pro Asp Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Arg Ser Ser Lys Ser Ala Ser Leu Thr Ile Ser Asn 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr Ser Ser 
                85                  90                  95      


Gly Phe Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  211
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 1 Kabat LCDR1

<400>  211

Lys Arg Asn Thr Gly Asn Ile Gly Ser Asn Tyr Val Asn 
1               5                   10              


<210>  212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 1 Kabat LCDR2

<400>  212

Arg Asn Asp Lys Arg Pro Asp 
1               5           


<210>  213

<400>  213

000               


<210>  214
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 1 Kabat LCDR3

<400>  214

Gln Ser Tyr Ser Ser Gly Phe Ile 
1               5               


<210>  215
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 2 VH

<400>  215

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asn Tyr Tyr 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Arg Ser Gly Gly Arg Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Thr Gln Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Asp Gly Arg Asp Gly Trp Val Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  216
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 2 Kabat HCDR1

<400>  216

Tyr Tyr Gly Met Ser 
1               5   


<210>  217
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 2 Kabat HCDR2

<400>  217

Ser Ile Thr Arg Ser Gly Gly Arg Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  218
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 2 Kabat HCDR3

<400>  218

Asp Gly Arg Asp Gly Trp Val Ala Tyr 
1               5                   


<210>  219
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 2 VL

<400>  219

Asn Phe Met Leu Thr Gln Pro Ser Ser Val Ser Gly Val Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Asn Thr Gly Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asp Asp Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Phe Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ser Ser Gly Phe 
                85                  90                  95      


Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  220
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 2 Kabat LCDR1

<400>  220

Thr Gly Asn Thr Gly Asn Ile Gly Ser Asn Tyr Val Asn 
1               5                   10              


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 2 Kabat LCDR2

<400>  221

Arg Asp Asp Lys Arg Pro Ser 
1               5           


<210>  222
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 2 Kabat LCDR3

<400>  222

Gln Ser Tyr Ser Ser Gly Phe Ile 
1               5               


<210>  223
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 3 VH

<400>  223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  224
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 3 Kabat HCDR1

<400>  224

Lys Tyr Ala Met Asn 
1               5   


<210>  225
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 3 Kabat HCDR2

<400>  225

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  226
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 3 Kabat HCDR3

<400>  226

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  227
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 3 VL

<400>  227

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  228
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 3 Kabat LCDR1

<400>  228

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210>  229
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 3 Kabat LCDR2

<400>  229

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  230
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 3 Kabat LCDR3

<400>  230

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  231
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 4 VH

<400>  231

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  232
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 4 Kabat HCDR1

<400>  232

Thr Tyr Ala Met Asn 
1               5   


<210>  233
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 4 Kabat HCDR2

<400>  233

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  234
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 4 Kabat HCDR3

<400>  234

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  235
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 4 VL

<400>  235

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  236
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 4 Kabat LCDR1

<400>  236

Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 4 Kabat LCDR2

<400>  237

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  238
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 4 Kabat LCDR3

<400>  238

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  239
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 5 VH

<400>  239

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  240
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 5 Kabat HCDR1

<400>  240

Arg Ser Thr Met His 
1               5   


<210>  241
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 5 Kabat HCDR2

<400>  241

Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  242
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 5 Kabat HCDR3

<400>  242

Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10          


<210>  243
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 5 VL

<400>  243

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  244
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 5 Kabat LCDR1

<400>  244

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  245
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 5 Kabat LCDR2

<400>  245

Asp Ser Ser Lys Leu Ala Ser 
1               5           


<210>  246
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 paratope 5 Kabat LCDR3

<400>  246

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  247
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member CD80 Residue 35-135

<400>  247

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  248
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member CD86 Residue 33-131

<400>  248

Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
1               5                   10                  15      


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
            20                  25                  30          


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
        35                  40                  45              


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
    50                  55                  60                  


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
65                  70                  75                  80  


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
                85                  90                  95      


Glu Leu Ser 
            


<210>  249
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member PD-L1 Residue 19-127

<400>  249

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr 
            100                 105                 


<210>  250
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member PD-L2 Residue 21-118

<400>  250

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  251
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member CTLA-4 Residue 39-140

<400>  251

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  252
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member PD-1 Residue 35-145

<400>  252

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  253
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member CD28 Residue 28-137

<400>  253

Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
1               5                   10                  15      


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
            20                  25                  30          


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
        35                  40                  45              


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
    50                  55                  60                  


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
65                  70                  75                  80  


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
                85                  90                  95      


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
            100                 105                 110 


<210>  254
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member CD47 Residue 19-127

<400>  254

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile 
            100                 105                 


<210>  255
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member SIRPa Residue 32-137

<400>  255

Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala 
1               5                   10                  15      


Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val 
            20                  25                  30          


Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile 
        35                  40                  45              


Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp 
    50                  55                  60                  


Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile 
65                  70                  75                  80  


Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly 
                85                  90                  95      


Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 
            100                 105     


<210>  256
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member ICOSL Residue 19-129

<400>  256

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  257
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member ICOS Residue 30-132

<400>  257

Met Phe Ile Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro 
1               5                   10                  15      


Asp Ile Val Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile 
            20                  25                  30          


Leu Cys Asp Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile 
        35                  40                  45              


Lys Ser Leu Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser 
    50                  55                  60                  


Phe Phe Leu Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys 
65                  70                  75                  80  


Asn Leu Ser Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly 
                85                  90                  95      


Gly Tyr Leu His Ile Tyr Glu 
            100             


<210>  258
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member CD276 Residue 29-139

<400>  258

Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr 
1               5                   10                  15      


Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu 
            20                  25                  30          


Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val 
        35                  40                  45              


His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg 
    50                  55                  60                  


Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg 
65                  70                  75                  80  


Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val 
                85                  90                  95      


Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala 
            100                 105                 110     


<210>  259
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member VTCN1 35-146 Residue 35-146

<400>  259

His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu 
1               5                   10                  15      


Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp 
            20                  25                  30          


Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu 
        35                  40                  45              


Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg 
    50                  55                  60                  


Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser 
65                  70                  75                  80  


Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys 
                85                  90                  95      


Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys 
            100                 105                 110         


<210>  260
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member VISTA Residue 33-168

<400>  260

Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
            20                  25                  30          


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
    50                  55                  60                  


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
65                  70                  75                  80  


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
                85                  90                  95      


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
            100                 105                 110         


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
        115                 120                 125             


His Gly Ala Met Glu Leu Gln Val 
    130                 135     


<210>  261
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member NCR3LG1 Residue 27-138

<400>  261

Lys Val Glu Met Met Ala Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp 
1               5                   10                  15      


Asn Val Thr Ile Phe Cys Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile 
            20                  25                  30          


Thr Ser Met Gly Ile Thr Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys 
        35                  40                  45              


Glu Val Lys Val Phe Glu Phe Phe Gly Asp His Gln Glu Ala Phe Arg 
    50                  55                  60                  


Pro Gly Ala Ile Val Ser Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Leu Arg Leu Pro Gly Ile Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys 
                85                  90                  95      


Glu Val Val Val Thr Pro Leu Lys Ala Gln Gly Thr Val Gln Leu Glu 
            100                 105                 110         


<210>  262
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member HHLA2 Residue 61-131

<400>  262

Ile His Trp Lys Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys 
1               5                   10                  15      


Gly Ser Asp His Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr 
            20                  25                  30          


Ser Leu Phe Tyr Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe 
        35                  40                  45              


Arg Arg Val Ser Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly 
    50                  55                  60                  


Thr Ala Ile Gln Val Ile Thr 
65                  70      


<210>  263
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member CD28H Residue 23-129

<400>  263

Leu Ser Val Gln Gln Gly Pro Asn Leu Leu Gln Val Arg Gln Gly Ser 
1               5                   10                  15      


Gln Ala Thr Leu Val Cys Gln Val Asp Gln Ala Thr Ala Trp Glu Arg 
            20                  25                  30          


Leu Arg Val Lys Trp Thr Lys Asp Gly Ala Ile Leu Cys Gln Pro Tyr 
        35                  40                  45              


Ile Thr Asn Gly Ser Leu Ser Leu Gly Val Cys Gly Pro Gln Gly Arg 
    50                  55                  60                  


Leu Ser Trp Gln Ala Pro Ser His Leu Thr Leu Gln Leu Asp Pro Val 
65                  70                  75                  80  


Ser Leu Asn His Ser Gly Ala Tyr Val Cys Trp Ala Ala Val Glu Ile 
                85                  90                  95      


Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile Thr 
            100                 105         


<210>  264
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgSF Member NKp30 Residue 19-126

<400>  264

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val 
            100                 105             


<210>  265
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mask linker

<400>  265

Gly Pro Pro Pro Gly 
1               5   


<210>  266
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mask linker

<400>  266

Gly Gly Pro Pro Pro Gly Gly 
1               5           


<210>  267
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mask linker

<400>  267

Gly Pro Pro Pro Pro Gly 
1               5       


<210>  268
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mask linker

<400>  268

Gly Gly Pro Pro Pro Gly Gly 
1               5           


