                         SEQUENCE LISTING

<110>  Filamon Pty Ltd
 
<120>  Vimentin Inhibitors

<130>  191413PCT

<150>  AU 2020902552
<151>  2020-07-22

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2151
<212>  DNA
<213>  Homo sapiens

<400>  1
gcctctccaa aggctgcaga agtttcttgc taacaaaaag tccgcacatt cgagcaaaga       60

caggctttag cgagttatta aaaacttagg ggcgctcttg tcccccacag ggcccgaccg      120

cacacagcaa ggcgatggcc cagctgtaag ttggtagcac tgagaactag cagcgcgcgc      180

ggagcccgct gagacttgaa tcaatctggt ctaacggttt cccctaaacc gctaggagcc      240

ctcaatcggc gggacagcag ggcgcgtcct ctgccactct cgctccgagg tccccgcgcc      300

agagacgcag ccgcgctccc accacccaca cccaccgcgc cctcgttcgc ctcttctccg      360

ggagccagtc cgcgccaccg ccgccgccca ggccatcgcc accctccgca gccatgtcca      420

ccaggtccgt gtcctcgtcc tcctaccgca ggatgttcgg cggcccgggc accgcgagcc      480

ggccgagctc cagccggagc tacgtgacta cgtccacccg cacctacagc ctgggcagcg      540

cgctgcgccc cagcaccagc cgcagcctct acgcctcgtc cccgggcggc gtgtatgcca      600

cgcgctcctc tgccgtgcgc ctgcggagca gcgtgcccgg ggtgcggctc ctgcaggact      660

cggtggactt ctcgctggcc gacgccatca acaccgagtt caagaacacc cgcaccaacg      720

agaaggtgga gctgcaggag ctgaatgacc gcttcgccaa ctacatcgac aaggtgcgct      780

tcctggagca gcagaataag atcctgctgg ccgagctcga gcagctcaag ggccaaggca      840

agtcgcgcct gggggacctc tacgaggagg agatgcggga gctgcgccgg caggtggacc      900

agctaaccaa cgacaaagcc cgcgtcgagg tggagcgcga caacctggcc gaggacatca      960

tgcgcctccg ggagaaattg caggaggaga tgcttcagag agaggaagcc gaaaacaccc     1020

tgcaatcttt cagacaggat gttgacaatg cgtctctggc acgtcttgac cttgaacgca     1080

aagtggaatc tttgcaagaa gagattgcct ttttgaagaa actccacgaa gaggaaatcc     1140

aggagctgca ggctcagatt caggaacagc atgtccaaat cgatgtggat gtttccaagc     1200

ctgacctcac ggctgccctg cgtgacgtac gtcagcaata tgaaagtgtg gctgccaaga     1260

acctgcagga ggcagaagaa tggtacaaat ccaagtttgc tgacctctct gaggctgcca     1320

accggaacaa tgacgccctg cgccaggcaa agcaggagtc cactgagtac cggagacagg     1380

tgcagtccct cacctgtgaa gtggatgccc ttaaaggaac caatgagtcc ctggaacgcc     1440

agatgcgtga aatggaagag aactttgccg ttgaagctgc taactaccaa gacactattg     1500

gccgcctgca ggatgagatt cagaatatga aggaggaaat ggctcgtcac cttcgtgaat     1560

accaagacct gctcaatgtt aagatggccc ttgacattga gattgccacc tacaggaagc     1620

tgctggaagg cgaggagagc aggatttctc tgcctcttcc aaacttttcc tccctgaacc     1680

tgagggaaac taatctggat tcactccctc tggttgatac ccactcaaaa aggacacttc     1740

tgattaagac ggttgaaact agagatggac aggttatcaa cgaaacttct cagcatcacg     1800

atgaccttga ataaaaattg cacacactca gtgcagcaat atattaccag caagaataaa     1860

aaagaaatcc atatcttaaa gaaacagctt tcaagtgcct ttctgcagtt tttcaggagc     1920

gcaagataga tttggaatag gaataagctc tagttcttaa caaccgacac tcctacaaga     1980

tttagaaaaa agtttacaac ataatctagt ttacagaaaa atcttgtgct agaatacttt     2040

ttaaaaggta ttttgaatac cattaaaact gctttttttt ttccagcaag tatccaacca     2100

acttggttct gcttcaataa atctttggaa aaactcaaaa aaaaaaaaaa a              2151


<210>  2
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized sequence of vimentin

<400>  2
catatgagca cccgtagcgt tagcgctagc gcttatcgtc gtatgtttgg tggtccgggt       60

acagcaagcc gtccgagctc tagccgtagc tatgttacca caagtacccg tacctatagc      120

ctgggtagcg cactgcgtcc gagtaccagt cgtagcctgt atgcaagcag tccgggcggt      180

gtttatgcaa cccgtagctc tgcagttcgt ctgcgtagca gtgttccggg tgtgcgtctg      240

ttgcaggata gcgttgattt tagcctggca gatgcaatta acaccgaatt caagaatacc      300

cgcaccaacg agaaagtgga actgcaagaa ctgaatgatc gctttgccaa ctatattgat      360

aaagtgcgtt ttctggaaca gcaaaacaaa attctgttgg cagaactgga acaactgaaa      420

ggtcagggta aaagccgtct gggtgatctg tatgaagagg aaatgcgcga actgcgtcgc      480

caggttgatc agctgaccaa tgataaagca cgtgttgaag ttgaacgtga taatctggcc      540

gaagatatta tgcgtctgcg tgagaaactg caagaagaga tgctgcagcg cgaagaggca      600

gaaaacaccc tgcagagctt tcgtcaggat gttgataatg caagcctggc acgtctggat      660

ctggaacgta aagttgaaag cctgcaagaa gagattgcct tcctgaagaa actgcatgaa      720

gaggaaatcc aagaactgca ggcacagatt caagaacagc atgttcagat tgatgtggat      780

gttagcaaac cggatctgac cgcggcactg cgtgatgttc gtcagcaata tgaaagcgtt      840

gcggcaaaga atctgcaaga ggcagaagag tggtataaaa gcaaattcgc agatctgagc      900

gaagcagcca atcgtaacaa tgatgccctg cgtcaggcaa aacaagaaag caccgaatat      960

cgtcgccagg ttcagagcct gacctgtgaa gttgatgcac tgaaaggcac caatgaatca     1020

ctggaacgtc agatgcgtga aatggaagag aattttgcag ttgaagcagc caattatcag     1080

gataccattg gtcgtctgca ggatgaaatt cagaacatga aagaagagat ggcacgtcat     1140

ctgcgtgaat atcaggatct gttgaatgtt aaaatggccc tggatattga aattgccacc     1200

tatcgtaaac tgttggaagg tgaagagagc cgtattagcc tgccgctgcc gaatttctca     1260

agcctgaatc tgcgcgaaac caatctggat agtctgccgc tggttgatac ccatagcaaa     1320

cgtaccctgt tgattaaaac cgttgaaacc cgtgatggtc aggtgattaa tgaaaccagc     1380

cagcatcacg atgacctgga ataataagaa tcc                                  1413


<210>  3
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  4
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


