                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
       GENUS ONCOLOGY, LLC
 
<120>  ANTIBODIES AGAINST THE MUC1-C/EXTRACELLULAR DOMAIN (MUC1-C/ECD)

<130>  GENU.P0047WO

<140>  Filed Concurrently Herewith
<141>  2021-07-15

<150>  US 63/052,599
<151>  2020-07-16

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile 
    50                  55                  60                  


Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr 
65                  70                  75                  80  


Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 
                85                  90                  95      


Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 
            100                 105                 110         


Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 
        115                 120                 125             


Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 
    130                 135                 140                 


Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
145                 150                 155             


<210>  2
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    50                  55              


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Ser Tyr Trp Met His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Glu Ile Asn Pro Ser Asn Gly Arg Thr Tyr Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Asp Gly Asp Tyr Val Ser Gly Phe Ala Tyr 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Gly Phe Thr Phe Asn Tyr Phe Trp 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Ile Leu Pro Gly Thr Gly Ser Thr 
1               5               


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Arg Tyr Asp Tyr Thr Ser Ser Met Asp Tyr 
1               5                   10  


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Lys Ala Ser Glu Asn Val Gly Thr Tyr Val Ser 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Gly Gln Ser Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Cys Arg Ala Ser Glu Ser Val Gln Tyr Ser Gly Thr Ser Leu Met His 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Gly Ala Ser Asn Val Glu Thr 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Gln Gln Asn Trp Lys Val Pro Trp Thr 
1               5                   


<210>  15
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val Asp Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Glu Lys Leu Ser Cys Lys Ala Ser Gly His Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Asn Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Tyr Ser Ser 
                85                  90                  95      


Ser Ala Ser Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Asp Tyr Val Ser Gly Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210>  16
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Met Glu Ser Gln Thr Leu Val Phe Ile Ser Ile Leu Leu Trp Leu Tyr 
1               5                   10                  15      


Gly Ala Asp Gly Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser 
            20                  25                  30          


Met Ser Val Gly Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn 
        35                  40                  45              


Val Gly Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asn 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Gly Gln Ser Tyr 
            100                 105                 110         


Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  17
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ile Gly Phe Thr Phe Asn Tyr Phe 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Tyr Asp Tyr Thr Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  18
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Asp Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Gln Tyr Ser 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Val Glu Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Asn Trp 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  19
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Tyr Phe Trp Ile Glu Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Asp Tyr Thr Ser Ser Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  20
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              


Gln Tyr Ser Gly Thr Ser Leu Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Val Glu Thr Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Asn Trp Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  21
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
atgggatgga gctatatcat cctctttttg gtagcaacag ctacagatgt cgactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcaga gaagctgtcc      120

tgcaaggctt ctgggcacac cttcaccagc tactggatgc actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggagagatt aatcctagca acggtcgtac ttactacaat      240

gagaacttca agaccaaggc cacactgact gtagacaaat attccagctc agcctccatg      300

caactccgca gcctgacatc tgaggactct gcggtctatt actgtgcaag tgatggtgac      360

tacgtctcgg gctttgccta ctggggccaa ggcaccactc tcacagtctc ctca            414


<210>  22
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22

Ala Thr Gly Gly Ala Ala Thr Cys Ala Cys Ala Gly Ala Cys Thr Cys 
1               5                   10                  15      


Thr Gly Gly Thr Cys Thr Thr Cys Ala Thr Ala Thr Cys Cys Ala Thr 
            20                  25                  30          


Ala Cys Thr Gly Cys Thr Cys Thr Gly Gly Thr Thr Ala Thr Ala Thr 
        35                  40                  45              


Gly Gly Thr Gly Cys Thr Gly Ala Thr Gly Gly Gly Ala Ala Cys Ala 
    50                  55                  60                  


Thr Thr Gly Thr Ala Ala Thr Gly Ala Cys Cys Cys Ala Ala Thr Cys 
65                  70                  75                  80  


Thr Cys Cys Cys Ala Ala Ala Thr Cys Cys Ala Thr Gly Thr Cys Cys 
                85                  90                  95      


Ala Thr Gly Thr Cys Ala Gly Thr Ala Gly Gly Ala Gly Ala Gly Ala 
            100                 105                 110         


Gly Gly Gly Thr Cys Ala Cys Cys Thr Thr Gly Ala Cys Cys Thr Gly 
        115                 120                 125             


Cys Ala Ala Gly Gly Cys Cys Ala Gly Thr Gly Ala Gly Ala Ala Thr 
    130                 135                 140                 


Gly Thr Gly Gly Gly Thr Ala Cys Thr Thr Ala Thr Gly Thr Ala Thr 
145                 150                 155                 160 


Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys Ala Gly Ala Ala 
                165                 170                 175     


Ala Cys Cys Ala Gly Ala Gly Cys Ala Gly Thr Cys Thr Cys Cys Thr 
            180                 185                 190         


Ala Ala Ala Cys Thr Ala Cys Thr Gly Ala Thr Ala Thr Ala Cys Gly 
        195                 200                 205             


Gly Gly Gly Cys Ala Thr Cys Cys Ala Ala Cys Cys Gly Gly Thr Ala 
    210                 215                 220                 


Cys Ala Cys Thr Gly Gly Gly Gly Thr Cys Cys Cys Cys Ala Ala Thr 
225                 230                 235                 240 


Cys Gly Cys Thr Thr Cys Ala Cys Ala Gly Gly Cys Ala Gly Thr Gly 
                245                 250                 255     


Gly Ala Thr Cys Thr Gly Cys Ala Ala Cys Ala Gly Ala Thr Thr Thr 
            260                 265                 270         


Cys Ala Cys Thr Cys Thr Gly Ala Cys Cys Ala Thr Cys Ala Gly Cys 
        275                 280                 285             


Ala Gly Thr Gly Thr Gly Cys Ala Gly Gly Cys Thr Gly Ala Ala Gly 
    290                 295                 300                 


Ala Cys Cys Thr Thr Gly Cys Ala Gly Ala Thr Thr Ala Thr Thr Ala 
305                 310                 315                 320 


Cys Thr Gly Thr Gly Gly Ala Cys Ala Gly Ala Gly Thr Thr Ala Cys 
                325                 330                 335     


Ala Gly Cys Thr Ala Thr Cys Cys Gly Thr Gly Gly Ala Cys Gly Thr 
            340                 345                 350         


Thr Cys Gly Gly Thr Gly Gly Ala Gly Gly Cys Ala Cys Cys Ala Ala 
        355                 360                 365             


Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys Ala Ala Ala 
    370                 375                 380     


<210>  23
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23

Cys Ala Gly Gly Thr Cys Cys Ala Gly Cys Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Ala Gly Cys Thr Gly Ala Gly Cys Thr 
            20                  25                  30          


Gly Ala Thr Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Thr Cys Ala Gly Thr Gly Ala Ala Ala Ala Thr Thr Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Thr Ala Thr Thr Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Cys Ala Thr Thr Cys Ala Ala Thr Thr Ala Cys Thr Thr Cys 
                85                  90                  95      


Thr Gly Gly Ala Thr Ala Gly Ala Gly Thr Gly Gly Gly Thr Ala Ala 
            100                 105                 110         


Ala Ala Cys Ala Gly Ala Gly Gly Cys Cys Thr Gly Gly Gly Cys Ala 
        115                 120                 125             


Thr Gly Gly Cys Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Ala Gly Ala Gly Ala Thr Thr Thr Thr Ala Cys Cys Thr Gly 
145                 150                 155                 160 


Gly Ala Ala Cys Thr Gly Gly Thr Ala Gly Thr Ala Cys Thr Ala Ala 
                165                 170                 175     


Cys Thr Ala Cys Ala Ala Thr Gly Ala Gly Ala Ala Gly Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Ala Ala Gly Gly Cys Cys Ala Thr Ala Thr 
        195                 200                 205             


Thr Cys Ala Cys Thr Gly Cys Ala Gly Ala Thr Ala Cys Ala Thr Cys 
    210                 215                 220                 


Cys Thr Cys Cys Ala Ala Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Ala Thr Gly Cys Ala Ala Cys Thr Cys Cys Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Thr Cys 
            260                 265                 270         


Thr Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Thr Ala Ala Gly Ala Thr Ala Cys Gly Ala Cys Thr Ala Thr Ala 
    290                 295                 300                 


Cys Cys Thr Cys Thr Thr Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala 
305                 310                 315                 320 


Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala Ala Cys Cys 
                325                 330                 335     


Thr Cys Ala Gly Thr Cys Ala Cys Ala Gly Thr Cys Thr Cys Cys Thr 
            340                 345                 350         


Cys Ala 
        


<210>  24
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
gacattgtgc tcacccaatc tccaggttct ttggctgtgt ctctagggca gagtgtcacc       60

atctcctgca gagccagtga aagtgttcaa tattctggca ctagtttaat gcactggtat      120

caacagaaac caggacagcc acccaaactc ctcatctatg gtgcatccaa cgtagagact      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaaattggaa ggttccttgg      300

acgttcggtg gaggcaccaa gctggaaata aaa                                   333


<210>  25
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  25

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              


Gln Tyr Ser Gly Thr Ser Leu Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Val Glu Thr Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Asn Trp Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  26
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              


Gln Tyr Ser Gly Thr Ser Leu Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Val Glu Thr Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Asn Trp Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  27
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgag       60

gtgcagctgg tgcagtccgg agcagaggtg aagaagccag gcgagtctct gaagatcagc      120

tgcaagggct ccggcttcac ctttaactac ttctggatcg agtgggtgcg gcagatgcca      180

ggcaagggcc tggagtggat gggagagatc ctgcctggca ccggctctac aaactacaat      240

gagaagttta agggccaggt gaccatcagc gccgacaaga gcatctccac agcctatctg      300

cagtggagct ccctgaaggc ctctgatacc gccatgtact attgtgccag atacgactat      360

acatctagca tggattattg gggccagggc accctggtga cagtgtcctc t               411


<210>  28
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28

Ala Thr Gly Gly Gly Cys Thr Gly Gly Ala Gly Cys Thr Gly Gly Ala 
1               5                   10                  15      


Thr Cys Cys Thr Gly Cys Thr Gly Thr Thr Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Gly Ala Gly Cys Gly Thr Gly Ala Cys Ala Gly Cys Ala Gly Gly Ala 
        35                  40                  45              


Gly Thr Gly Cys Ala Cys Ala Gly Cys Gly Ala Gly Ala Thr Cys Gly 
    50                  55                  60                  


Thr Gly Cys Thr Gly Ala Cys Cys Cys Ala Gly Thr Cys Thr Cys Cys 
65                  70                  75                  80  


Ala Gly Cys Cys Ala Cys Ala Cys Thr Gly Thr Cys Thr Cys Thr Gly 
                85                  90                  95      


Ala Gly Cys Cys Cys Ala Gly Gly Ala Gly Ala Gly Ala Gly Gly Gly 
            100                 105                 110         


Cys Cys Ala Cys Cys Cys Thr Gly Ala Gly Cys Thr Gly Cys Ala Gly 
        115                 120                 125             


Ala Gly Cys Cys Thr Cys Cys Gly Ala Gly Thr Cys Thr Gly Thr Gly 
    130                 135                 140                 


Cys Ala Gly Thr Ala Cys Ala Gly Cys Gly Gly Cys Ala Cys Ala Thr 
145                 150                 155                 160 


Cys Cys Cys Thr Gly Ala Thr Gly Cys Ala Cys Thr Gly Gly Thr Ala 
                165                 170                 175     


Thr Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys Ala Gly Gly Ala 
            180                 185                 190         


Cys Ala Gly Gly Cys Ala Cys Cys Thr Ala Gly Gly Cys Thr Gly Cys 
        195                 200                 205             


Thr Gly Ala Thr Cys Thr Ala Cys Gly Gly Cys Gly Cys Cys Thr Cys 
    210                 215                 220                 


Cys Ala Ala Cys Gly Thr Gly Gly Ala Gly Ala Cys Ala Gly Gly Ala 
225                 230                 235                 240 


Ala Thr Cys Cys Cys Ala Gly Cys Ala Cys Gly Gly Thr Thr Cys Ala 
                245                 250                 255     


Gly Cys Gly Gly Ala Thr Cys Cys Gly Gly Ala Thr Cys Thr Gly Gly 
            260                 265                 270         


Cys Ala Cys Ala Gly Ala Cys Thr Thr Thr Ala Cys Cys Cys Thr Gly 
        275                 280                 285             


Ala Cys Ala Ala Thr Cys Ala Gly Cys Thr Cys Cys Cys Thr Gly Gly 
    290                 295                 300                 


Ala Gly Cys Cys Thr Gly Ala Gly Gly Ala Thr Thr Thr Cys Gly Cys 
305                 310                 315                 320 


Cys Gly Thr Gly Thr Ala Cys Thr Ala Thr Thr Gly Thr Cys Ala Gly 
                325                 330                 335     


Cys Ala Gly Ala Ala Thr Thr Gly Gly Ala Ala Gly Gly Thr Gly Cys 
            340                 345                 350         


Cys Ala Thr Gly Gly Ala Cys Cys Thr Thr Thr Gly Gly Cys Cys Ala 
        355                 360                 365             


Gly Gly Gly Cys Ala Cys Ala Ala Ala Gly Gly Thr Gly Gly Ala Gly 
    370                 375                 380                 


Ala Thr Cys Ala Ala Gly 
385                 390 


<210>  29
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgac       60

atccagatga cccagtcccc tagctccctg tccgcctctg tgggcgatcg ggtgaccatc      120

acatgcagag ccagcgagtc cgtgcagtac tctggcacaa gcctgatgca ctggtatcag      180

cagaagcccg gcaaggcccc taagctgctg atctacggag catccaacgt ggagacagga      240

gtgccatctc ggttctctgg aagcggatcc ggcacagact tcacctttac aatctctagc      300

ctgcagccag aggatatcgc cacctactat tgtcagcaga attggaaggt gccctggacc      360

tttggccagg gcacaaagct ggagatcaag                                       390


<210>  30
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgac       60

atccagatga cccagtcccc tagctccctg tccgcctctg tgggcgatcg ggtgaccatc      120

acatgcagag ccagcgagtc cgtgcagtac tctggcacaa gcctgatgca ctggtatcag      180

cagaagcccg gcaaggcccc taagctgctg atctacggag catccaacgt ggagacagga      240

gtgccatctc ggttctctgg aagcggatcc ggcacagact ttaccctgac aatctctagc      300

ctgcagccag aggatttcgc cacctactat tgtcagcaga attggaaggt gccctggacc      360

tttggcggcg gcacaaaggt ggagatcaag                                       390


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  31

Cys Gln Cys Arg 
1               


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Cys Gln Cys Arg Arg 
1               5   


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  33

Cys Gln Cys Arg Arg Arg 
1               5       


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  34

Cys Gln Cys Arg Arg Arg Arg 
1               5           


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  35

Cys Gln Cys Arg Arg Lys 
1               5       


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Cys Gln Cys Arg Arg Lys Asn 
1               5           


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  37

Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys Gln Cys Arg Arg Lys Asn 
1               5                   10                  15      


<210>  38
<211>  59
<212>  PRT
<213>  Macaca fascicularis

<400>  38

Ser Val Val Val Gln Ser Thr Leu Val Phe Arg Glu Gly Thr Thr Asn 
1               5                   10                  15      


Val His Asp Val Glu Glu Thr Gln Phe Asn Gln Arg Lys Thr Glu Ala 
            20                  25                  30          


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Ile Ser Val Arg Asp Val 
        35                  40                  45              


Pro Phe Pro Phe Ser Ala Gln Thr Gly Ala Gly 
    50                  55                  


<210>  39
<211>  58
<212>  PRT
<213>  Mus musculus

<400>  39

Ser Val Val Val Glu Ser Thr Val Val Phe Arg Glu Gly Thr Phe Ser 
1               5                   10                  15      


Ala Ser Asp Val Lys Ser Gln Leu Ile Gln His Lys Lys Glu Ala Asp 
            20                  25                  30          


Ser Asp Tyr Asn Leu Thr Ile Ser Glu Val Lys Val Asn Glu Met Gln 
        35                  40                  45              


Phe Pro Pro Ser Ala Gln Ser Arg Pro Gly 
    50                  55              


