                         SEQUENCE LISTING

<110>  Instil Bio (UK) Limited
       Bridgeman, John
       Hawkins, Robert
       Rodriguez, Ruben
 
<120>  Chimeric molecules providing targeted costimulation for adoptive 
       cell therapy

<130>  Y8551-99026

<140>  PCT/US2021/042079
<141>  2021-07-16

<150>  US 63/053,498
<151>  2020-07-17

<160>  158   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  signal peptide

<400>  1

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro 
            20      


<210>  2
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(105)
<223>  CD3D ECD-TMD

<400>  2

Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys 
1               5                   10                  15      


Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser 
            20                  25                  30          


Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly 
        35                  40                  45              


Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr 
    50                  55                  60                  


Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro 
65                  70                  75                  80  


Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu 
                85                  90                  95      


Leu Ala Leu Gly Val Phe Cys Phe Ala 
            100                 105 


<210>  3
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  CD28-CD40 costimulatory domain

<400>  3

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        35                  40                  45              


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    50                  55                  60                  


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
65                  70                  75                  80  


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                85                  90                  95      


Ile Ser Val Gln Glu Arg Gln 
            100             


<210>  4
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Arg Ser 
        115                 120                 125             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    130                 135                 140                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
145                 150                 155                 160 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                165                 170                 175     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            180                 185                 190         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        195                 200                 205             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    210                 215                 220                 


Val Gln Glu Arg Gln 
225                 


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  signal peptide

<400>  5

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln 
            20          


<210>  6
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(130)
<223>  CD3E ECD-TMD

<400>  6

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val 
            100                 105                 110         


Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr 
        115                 120                 125             


Trp Ser 
    130 


<210>  7
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  CD28-CD40 costimulatory domain

<400>  7

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        35                  40                  45              


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    50                  55                  60                  


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
65                  70                  75                  80  


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                85                  90                  95      


Ile Ser Val Gln Glu Arg Gln 
            100             


<210>  8
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Arg Ser Lys Arg Ser Arg Leu Leu 
145                 150                 155                 160 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                165                 170                 175     


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            180                 185                 190         


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
        195                 200                 205             


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
    210                 215                 220                 


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
225                 230                 235                 240 


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
                245                 250                 255 


<210>  9
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  signal peptide

<400>  9

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala 
            20          


<210>  10
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(115)
<223>  CD3G ECD-TMD

<400>  10

Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
1               5                   10                  15      


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
            20                  25                  30          


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
        35                  40                  45              


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
    50                  55                  60                  


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
65                  70                  75                  80  


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe 
                85                  90                  95      


Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly Val Tyr 
            100                 105                 110         


Phe Ile Ala 
        115 


<210>  11
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  CD28-CD40 costimulatory domain

<400>  11

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        35                  40                  45              


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    50                  55                  60                  


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
65                  70                  75                  80  


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                85                  90                  95      


Ile Ser Val Gln Glu Arg Gln 
            100             


<210>  12
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Arg Ser Lys Arg Ser Arg Leu 
    130                 135                 140                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
145                 150                 155                 160 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro 
            180                 185                 190         


Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser 
        195                 200                 205             


Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val 
    210                 215                 220                 


Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
225                 230                 235                 240 


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  signal peptide

<400>  13

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala 
            20      


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  CD3Z ECD-TMD

<400>  14

Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly 
1               5                   10                  15      


Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu Phe Leu 
            20                  25                  30  


<210>  15
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  CD28-CD40 costimulatory domain

<400>  15

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        35                  40                  45              


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    50                  55                  60                  


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
65                  70                  75                  80  


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                85                  90                  95      


Ile Ser Val Gln Glu Arg Gln 
            100             


<210>  16
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    50                  55                  60                  


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
65                  70                  75                  80  


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
                85                  90                  95      


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
            100                 105                 110         


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
        115                 120                 125             


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
    130                 135                 140                 


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
145                 150                 


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  signal peptide

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  18
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc
<222>  (1)..(153)
<223>  TRDC ECD-TMD

<400>  18

Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr 
1               5                   10                  15      


Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile 
            20                  25                  30          


Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val 
        35                  40                  45              


Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu 
    50                  55                  60                  


Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val 
65                  70                  75                  80  


His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys 
                85                  90                  95      


Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys 
            100                 105                 110         


Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr 
        115                 120                 125             


Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe 
    130                 135                 140                 


Leu Leu Thr Ala Lys Leu Phe Phe Leu 
145                 150             


<210>  19
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  CD28-CD40 costimulatory domain

<400>  19

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        35                  40                  45              


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    50                  55                  60                  


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
65                  70                  75                  80  


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                85                  90                  95      


Ile Ser Val Gln Glu Arg Gln 
            100             


<210>  20
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Pro His Thr Lys Pro Ser Val Phe Val 
            20                  25                  30          


Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro 
        35                  40                  45              


Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe 
    50                  55                  60                  


Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys 
65                  70                  75                  80  


Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser Val Gln His 
                85                  90                  95      


Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser 
            100                 105                 110         


Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser 
        115                 120                 125             


Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn 
    130                 135                 140                 


Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr 
145                 150                 155                 160 


Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu Arg Ser 
                165                 170                 175     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            180                 185                 190         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        195                 200                 205             


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  signal peptide

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  22
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(161)
<223>  TRGC1 ECD-TMD

<400>  22

Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
            20                  25                  30          


Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu 
        35                  40                  45              


Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys 
    50                  55                  60                  


Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys 
65                  70                  75                  80  


Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys 
                85                  90                  95      


Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val 
            100                 105                 110         


Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr 
        115                 120                 125             


Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu 
    130                 135                 140                 


Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu 
145                 150                 155                 160 


Leu 
    


<210>  23
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  CD28-CD40 costimulatory domain

<400>  23

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        35                  40                  45              


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    50                  55                  60                  


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
65                  70                  75                  80  


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                85                  90                  95      


Ile Ser Val Gln Glu Arg Gln 
            100             


<210>  24
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys 
            20                  25                  30          


Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala 
        35                  40                  45              


Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys 
    50                  55                  60                  


Ile His Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu 
65                  70                  75                  80  


Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                85                  90                  95      


Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg 
            100                 105                 110         


His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro 
        115                 120                 125             


Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys 
    130                 135                 140                 


Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr 
145                 150                 155                 160 


Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile 
                165                 170                 175     


Ile Thr Cys Cys Leu Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            180                 185                 190         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        195                 200                 205             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
    210                 215                 220                 


Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu 
225                 230                 235                 240 


Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala 
                245                 250                 255     


Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu 
            260                 265                 270         


Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
        275                 280                 285 


<210>  25
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  signal peptide

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  26
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(136)
<223>  TRAC ECD-TMD

<400>  26

Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
1               5                   10                  15      


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
            20                  25                  30          


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
        35                  40                  45              


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
    50                  55                  60                  


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
65                  70                  75                  80  


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
                85                  90                  95      


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val 
            100                 105                 110         


Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
        115                 120                 125             


Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135     


<210>  27
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  CD28-CD40 costimulatory domain

<400>  27

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        35                  40                  45              


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    50                  55                  60                  


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
65                  70                  75                  80  


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                85                  90                  95      


Ile Ser Val Gln Glu Arg Gln 
            100             


<210>  28
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
            20                  25                  30          


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
        35                  40                  45              


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
    50                  55                  60                  


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
65                  70                  75                  80  


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
                85                  90                  95      


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
            100                 105                 110         


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
        115                 120                 125             


Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala 
    130                 135                 140                 


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ser Lys 
145                 150                 155                 160 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                165                 170                 175     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            180                 185                 190         


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
        195                 200                 205             


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
    210                 215                 220                 


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
225                 230                 235                 240 


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
                245                 250                 255     


Gln Glu Arg Gln 
            260 


<210>  29
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  signal peptide

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  30
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(169)
<223>  TRBC1 ECD-TMD

<400>  30

Val Leu Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
1               5                   10                  15      


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
            20                  25                  30          


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
        35                  40                  45              


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
    50                  55                  60                  


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
65                  70                  75                  80  


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
                85                  90                  95      


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
            100                 105                 110         


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
        115                 120                 125             


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
    130                 135                 140                 


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
145                 150                 155                 160 


Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 


<210>  31
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  CD28-CD40 costimulatory domain

<400>  31

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        35                  40                  45              


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    50                  55                  60                  


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
65                  70                  75                  80  


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                85                  90                  95      


Ile Ser Val Gln Glu Arg Gln 
            100             


<210>  32
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Leu Thr Pro Pro Lys Val Ser Leu Phe Glu 
            20                  25                  30          


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
        35                  40                  45              


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
    50                  55                  60                  


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
65                  70                  75                  80  


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
                85                  90                  95      


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
            100                 105                 110         


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
        115                 120                 125             


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
    130                 135                 140                 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
145                 150                 155                 160 


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
                165                 170                 175     


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ser 
            180                 185                 190         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        195                 200                 205             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    210                 215                 220                 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
225                 230                 235                 240 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
                245                 250                 255     


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
            260                 265                 270         


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
        275                 280                 285             


Val Gln Glu Arg Gln 
    290             


<210>  33
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        35                  40                  45              


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
    50                  55                  60                  


Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
65                  70                  75                  80  


Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Ala Gln Lys Leu Gln 
                85                  90                  95      


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met 
            100                 105                 110         


Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Gly Gly Tyr Asp Phe Asp Val Gly Thr Leu Tyr Trp Phe Phe Asp 
    130                 135                 140                 


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                165                 170                 175     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
            180                 185                 190         


Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Lys Thr 
    210                 215                 220                 


Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
                245                 250                 255     


Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg Thr Phe Gly Gly Gly 
            260                 265                 270         


Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile 
        275                 280                 285             


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
    290                 295                 300                 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
305                 310                 315                 320 


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
                325                 330                 335     


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
            340                 345                 350         


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
        355                 360                 365             


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
    370                 375                 380                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
385                 390                 395                 400 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                405                 410                 415     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                485                 490                 495     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            500                 505                 510         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        515                 520                 525             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    530                 535                 540                 


Val Gln Glu Arg Gln 
545                 


<210>  34
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            100                 105                 110         


Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                165                 170                 175     


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Tyr Asp 
        195                 200                 205             


Ser Glu Thr His Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr 
    210                 215                 220                 


Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg 
225                 230                 235                 240 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr Asp Phe 
                245                 250                 255     


Asp Val Gly Thr Leu Tyr Trp Phe Phe Asp Val Trp Gly Gln Gly Thr 
            260                 265                 270         


Thr Val Thr Val Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile 
        275                 280                 285             


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
    290                 295                 300                 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
305                 310                 315                 320 


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
                325                 330                 335     


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
            340                 345                 350         


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
        355                 360                 365             


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
    370                 375                 380                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
385                 390                 395                 400 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                405                 410                 415     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                485                 490                 495     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            500                 505                 510         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        515                 520                 525             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    530                 535                 540                 


Val Gln Glu Arg Gln 
545                 


<210>  35
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp 
    50                  55                  60                  


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
65                  70                  75                  80  


Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Gly Ser Gly Asn Trp Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
                165                 170                 175     


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
            180                 185                 190         


Gly Ile Ser Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala 
        195                 200                 205             


Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
    210                 215                 220                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
225                 230                 235                 240 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
                245                 250                 255     


Asn Thr Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  36
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr 
65                  70                  75                  80  


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            100                 105                 110         


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Arg Thr 
        115                 120                 125             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met His Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly 
        195                 200                 205             


Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
225                 230                 235                 240 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Gly Asn Trp 
                245                 250                 255     


Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  37
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
        35                  40                  45              


Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr Tyr 
    50                  55                  60                  


Trp Ser Trp Ile Arg Gln Ser Pro Glu Gly Leu Glu Trp Ile Gly Glu 
65                  70                  75                  80  


Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu Ser Arg 
                85                  90                  95      


Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu 
            100                 105                 110         


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
        115                 120                 125             


Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
                165                 170                 175     


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
            180                 185                 190         


Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        195                 200                 205             


Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile 
    210                 215                 220                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
225                 230                 235                 240 


Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
                245                 250                 255     


Arg Ser Asn Trp Pro Pro Ala Leu Thr Phe Gly Gly Gly Thr Lys Val 
            260                 265                 270         


Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val 
        275                 280                 285             


Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser 
    290                 295                 300                 


Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu 
305                 310                 315                 320 


His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn 
                325                 330                 335     


Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp 
            340                 345                 350         


Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr 
        355                 360                 365             


Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro 
    370                 375                 380                 


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
385                 390                 395                 400 


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
                405                 410                 415     


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            420                 425                 430         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        435                 440                 445             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    450                 455                 460                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
465                 470                 475                 480 


Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala 
                485                 490                 495     


Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu 
            500                 505                 510         


Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys 
        515                 520                 525             


Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln 
    530                 535                 540                 


Glu Arg Gln 
545         


<210>  38
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
        35                  40                  45              


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
65                  70                  75                  80  


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
            100                 105                 110         


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Ala 
        115                 120                 125             


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu 
                165                 170                 175     


Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp 
            180                 185                 190         


Ile Arg Gln Ser Pro Glu Gly Leu Glu Trp Ile Gly Glu Ile Asn His 
        195                 200                 205             


Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu Ser Arg Val Thr Ile 
    210                 215                 220                 


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
225                 230                 235                 240 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Pro 
                245                 250                 255     


Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val 
            260                 265                 270         


Thr Val Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val 
        275                 280                 285             


Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser 
    290                 295                 300                 


Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu 
305                 310                 315                 320 


His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn 
                325                 330                 335     


Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp 
            340                 345                 350         


Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr 
        355                 360                 365             


Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro 
    370                 375                 380                 


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
385                 390                 395                 400 


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
                405                 410                 415     


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            420                 425                 430         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        435                 440                 445             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    450                 455                 460                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
465                 470                 475                 480 


Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala 
                485                 490                 495     


Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu 
            500                 505                 510         


Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys 
        515                 520                 525             


Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln 
    530                 535                 540                 


Glu Arg Gln 
545         


<210>  39
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr 
        35                  40                  45              


Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly 
    50                  55                  60                  


Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp 
65                  70                  75                  80  


Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu 
                85                  90                  95      


Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
            100                 105                 110         


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Thr Arg Arg Tyr Phe Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
                165                 170                 175     


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln 
            180                 185                 190         


Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        195                 200                 205             


Pro Arg Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Ile Pro 
    210                 215                 220                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
225                 230                 235                 240 


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
                245                 250                 255     


Asn Thr Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  40
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
        35                  40                  45              


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
65                  70                  75                  80  


Ser Ala Ser Tyr Arg Tyr Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
            100                 105                 110         


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Thr Asp Pro Leu Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Thr Leu Arg Glu Ser 
145                 150                 155                 160 


Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr 
                165                 170                 175     


Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp Ile 
            180                 185                 190         


Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala His Ile Trp Trp 
        195                 200                 205             


Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile 
    210                 215                 220                 


Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met 
225                 230                 235                 240 


Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Thr Arg Arg Tyr 
                245                 250                 255     


Phe Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  41
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala Ser 
        35                  40                  45              


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Tyr 
    50                  55                  60                  


Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
65                  70                  75                  80  


Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
                85                  90                  95      


Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met 
            100                 105                 110         


Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
                165                 170                 175     


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
            180                 185                 190         


Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln 
        195                 200                 205             


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu 
    210                 215                 220                 


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
225                 230                 235                 240 


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
                245                 250                 255     


Tyr Cys Gln His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr 
            260                 265                 270         


Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile 
        275                 280                 285             


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
    290                 295                 300                 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
305                 310                 315                 320 


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
                325                 330                 335     


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
            340                 345                 350         


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
        355                 360                 365             


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
    370                 375                 380                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
385                 390                 395                 400 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                405                 410                 415     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                485                 490                 495     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            500                 505                 510         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        515                 520                 525             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    530                 535                 540                 


Val Gln Glu Arg Gln 
545                 


<210>  42
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
        35                  40                  45              


Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser Gly 
    50                  55                  60                  


Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
65                  70                  75                  80  


Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg 
                85                  90                  95      


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            100                 105                 110         


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg Asp 
        115                 120                 125             


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
145                 150                 155                 160 


Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val 
                165                 170                 175     


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Tyr Met 
            180                 185                 190         


Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly 
        195                 200                 205             


Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys Asn 
    210                 215                 220                 


Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                245                 250                 255     


Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Thr Val Thr Val Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile 
        275                 280                 285             


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
    290                 295                 300                 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
305                 310                 315                 320 


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
                325                 330                 335     


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
            340                 345                 350         


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
        355                 360                 365             


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
    370                 375                 380                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
385                 390                 395                 400 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                405                 410                 415     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                485                 490                 495     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            500                 505                 510         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        515                 520                 525             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    530                 535                 540                 


Val Gln Glu Arg Gln 
545                 


<210>  43
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp 
    50                  55                  60                  


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
65                  70                  75                  80  


Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                165                 170                 175     


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
            180                 185                 190         


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        195                 200                 205             


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
225                 230                 235                 240 


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu 
                245                 250                 255     


Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  44
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala Val 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            100                 105                 110         


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala Thr 
        115                 120                 125             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr 
        195                 200                 205             


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro 
                245                 250                 255     


Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  45
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        35                  40                  45              


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Trp 
    50                  55                  60                  


Ile Gly Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
65                  70                  75                  80  


Tyr Leu Tyr Pro Gly Gly Leu Tyr Thr Asn Tyr Asn Glu Lys Phe Lys 
                85                  90                  95      


Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr Met 
            100                 105                 110         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Tyr Arg Asp Tyr Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
                165                 170                 175     


Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Thr Lys 
            180                 185                 190         


Ser Leu Leu Asn Ser Asp Gly Phe Thr Tyr Leu Gly Trp Cys Leu Gln 
        195                 200                 205             


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn Arg 
    210                 215                 220                 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
225                 230                 235                 240 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
                245                 250                 255     


Tyr Cys Phe Gln Ser Asn Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr 
            260                 265                 270         


Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile 
        275                 280                 285             


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
    290                 295                 300                 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
305                 310                 315                 320 


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
                325                 330                 335     


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
            340                 345                 350         


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
        355                 360                 365             


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
    370                 375                 380                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
385                 390                 395                 400 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                405                 410                 415     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                485                 490                 495     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            500                 505                 510         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        515                 520                 525             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    530                 535                 540                 


Val Gln Glu Arg Gln 
545                 


<210>  46
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly Gln 
        35                  40                  45              


Pro Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser Asp 
    50                  55                  60                  


Gly Phe Thr Tyr Leu Gly Trp Cys Leu Gln Lys Pro Gly Gln Ser Pro 
65                  70                  75                  80  


Gln Leu Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro Asp 
                85                  90                  95      


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
            100                 105                 110         


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ser Asn 
        115                 120                 125             


Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
                165                 170                 175     


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Trp 
            180                 185                 190         


Ile Gly Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        195                 200                 205             


Tyr Leu Tyr Pro Gly Gly Leu Tyr Thr Asn Tyr Asn Glu Lys Phe Lys 
    210                 215                 220                 


Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr Met 
225                 230                 235                 240 


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Tyr Arg Asp Tyr Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile 
        275                 280                 285             


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
    290                 295                 300                 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
305                 310                 315                 320 


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
                325                 330                 335     


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
            340                 345                 350         


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
        355                 360                 365             


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
    370                 375                 380                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
385                 390                 395                 400 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                405                 410                 415     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                485                 490                 495     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            500                 505                 510         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        515                 520                 525             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    530                 535                 540                 


Val Gln Glu Arg Gln 
545                 


<210>  47
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
        35                  40                  45              


Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Gly Tyr 
    50                  55                  60                  


Trp Asn Trp Ile Arg Lys His Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
65                  70                  75                  80  


Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys Ser 
                85                  90                  95      


Arg Ile Thr Ile Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln 
            100                 105                 110         


Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        115                 120                 125             


Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
                165                 170                 175     


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
            180                 185                 190         


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
        195                 200                 205             


Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Lys Leu His Ser Gly 
    210                 215                 220                 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
225                 230                 235                 240 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
                245                 250                 255     


Gln Gly Ser Ala Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln 
        275                 280                 285             


Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys 
    290                 295                 300                 


Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys 
305                 310                 315                 320 


Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser 
                325                 330                 335     


Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys 
            340                 345                 350         


Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn 
        355                 360                 365             


Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro 
    370                 375                 380                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
385                 390                 395                 400 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                405                 410                 415     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            420                 425                 430         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        435                 440                 445             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    450                 455                 460                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
465                 470                 475                 480 


Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His 
                485                 490                 495     


Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly 
            500                 505                 510         


Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro 
        515                 520                 525             


Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg 
    530                 535                 540                 


Gln 
545 


<210>  48
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            100                 105                 110         


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Trp Thr 
        115                 120                 125             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala 
                165                 170                 175     


Val Tyr Gly Gly Ser Phe Ser Ser Gly Tyr Trp Asn Trp Ile Arg Lys 
            180                 185                 190         


His Pro Gly Lys Gly Leu Glu Tyr Ile Gly Tyr Ile Ser Tyr Asn Gly 
        195                 200                 205             


Ile Thr Tyr His Asn Pro Ser Leu Lys Ser Arg Ile Thr Ile Asn Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn Ser Val Thr Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Lys Tyr Asp Tyr Asp 
                245                 250                 255     


Gly Gly His Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln 
        275                 280                 285             


Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys 
    290                 295                 300                 


Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys 
305                 310                 315                 320 


Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser 
                325                 330                 335     


Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys 
            340                 345                 350         


Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn 
        355                 360                 365             


Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro 
    370                 375                 380                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
385                 390                 395                 400 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                405                 410                 415     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            420                 425                 430         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        435                 440                 445             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    450                 455                 460                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
465                 470                 475                 480 


Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His 
                485                 490                 495     


Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly 
            500                 505                 510         


Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro 
        515                 520                 525             


Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg 
    530                 535                 540                 


Gln 
545 


<210>  49
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr 
    50                  55                  60                  


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr 
65                  70                  75                  80  


Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
                165                 170                 175     


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
            180                 185                 190         


Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        195                 200                 205             


Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
225                 230                 235                 240 


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
                245                 250                 255     


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  50
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
        35                  40                  45              


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr 
    50                  55                  60                  


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
65                  70                  75                  80  


Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
                85                  90                  95      


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
            100                 105                 110         


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp 
        115                 120                 125             


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp 
        195                 200                 205             


Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu 
                245                 250                 255     


Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  51
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Val Ala Ser Gly Val Thr Phe Asp Asp Tyr Gly 
    50                  55                  60                  


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
65                  70                  75                  80  


Gly Ile Asn Trp Asn Gly Gly Asp Thr Asp Tyr Ser Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Asp Phe Tyr Gly Ser Gly Ser Tyr Tyr His Val Pro Phe Asp Tyr 
    130                 135                 140                 


Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
                165                 170                 175     


Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
            180                 185                 190         


Cys Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu Ala Trp Tyr Gln 
        195                 200                 205             


Gln Lys Arg Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
    210                 215                 220                 


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Asp Gly Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Ser Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
                245                 250                 255     


Tyr Tyr Cys His Gln Tyr Asp Met Ser Pro Phe Thr Phe Gly Pro Gly 
            260                 265                 270         


Thr Lys Val Asp Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile 
        275                 280                 285             


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
    290                 295                 300                 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
305                 310                 315                 320 


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
                325                 330                 335     


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
            340                 345                 350         


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
        355                 360                 365             


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
    370                 375                 380                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
385                 390                 395                 400 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                405                 410                 415     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                485                 490                 495     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            500                 505                 510         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        515                 520                 525             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    530                 535                 540                 


Val Gln Glu Arg Gln 
545                 


<210>  52
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
        35                  40                  45              


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr 
    50                  55                  60                  


Leu Ala Trp Tyr Gln Gln Lys Arg Gly Gln Ala Pro Arg Leu Leu Ile 
65                  70                  75                  80  


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
                85                  90                  95      


Asp Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Arg Leu Glu Pro 
            100                 105                 110         


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Asp Met Ser Pro Phe 
        115                 120                 125             


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Val Ala Ser Gly Val Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp Asn 
        195                 200                 205             


Gly Gly Asp Thr Asp Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Asp Phe Tyr Gly 
                245                 250                 255     


Ser Gly Ser Tyr Tyr His Val Pro Phe Asp Tyr Trp Gly Gln Gly Ile 
            260                 265                 270         


Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile 
        275                 280                 285             


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
    290                 295                 300                 


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
305                 310                 315                 320 


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
                325                 330                 335     


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
            340                 345                 350         


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
        355                 360                 365             


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
    370                 375                 380                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
385                 390                 395                 400 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                405                 410                 415     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            420                 425                 430         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        435                 440                 445             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    450                 455                 460                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
465                 470                 475                 480 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                485                 490                 495     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            500                 505                 510         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        515                 520                 525             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    530                 535                 540                 


Val Gln Glu Arg Gln 
545                 


<210>  53
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Thr Tyr 
    50                  55                  60                  


Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 
65                  70                  75                  80  


Cys Ile Tyr Thr Gly Asp Gly Thr Asn Tyr Ser Ala Ser Trp Ala Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
        115                 120                 125             


Arg Pro Asp Ile Thr Tyr Gly Phe Ala Ile Asn Phe Trp Gly Pro Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                165                 170                 175     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Lys Cys Gln Ala Ser 
            180                 185                 190         


Gln Ser Ile Ser Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        195                 200                 205             


Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
225                 230                 235                 240 


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Cys 
                245                 250                 255     


Thr Gly Tyr Gly Ile Ser Trp Pro Ile Gly Gly Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln 
        275                 280                 285             


Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys 
    290                 295                 300                 


Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys 
305                 310                 315                 320 


Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser 
                325                 330                 335     


Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys 
            340                 345                 350         


Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn 
        355                 360                 365             


Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro 
    370                 375                 380                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
385                 390                 395                 400 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                405                 410                 415     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            420                 425                 430         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        435                 440                 445             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    450                 455                 460                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
465                 470                 475                 480 


Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His 
                485                 490                 495     


Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly 
            500                 505                 510         


Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro 
        515                 520                 525             


Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg 
    530                 535                 540                 


Gln 
545 


<210>  54
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Arg Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            100                 105                 110         


Asp Val Ala Thr Tyr Tyr Cys Gln Cys Thr Gly Tyr Gly Ile Ser Trp 
        115                 120                 125             


Pro Ile Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Ser Phe Ser Ser Thr Tyr Val Cys Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Tyr Thr Gly 
        195                 200                 205             


Asp Gly Thr Asn Tyr Ser Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Pro Asp Ile Thr 
                245                 250                 255     


Tyr Gly Phe Ala Ile Asn Phe Trp Gly Pro Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln 
        275                 280                 285             


Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys 
    290                 295                 300                 


Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys 
305                 310                 315                 320 


Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser 
                325                 330                 335     


Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys 
            340                 345                 350         


Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn 
        355                 360                 365             


Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro 
    370                 375                 380                 


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
385                 390                 395                 400 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
                405                 410                 415     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            420                 425                 430         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        435                 440                 445             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    450                 455                 460                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
465                 470                 475                 480 


Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His 
                485                 490                 495     


Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly 
            500                 505                 510         


Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro 
        515                 520                 525             


Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg 
    530                 535                 540                 


Gln 
545 


<210>  55
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        35                  40                  45              


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr 
    50                  55                  60                  


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
65                  70                  75                  80  


Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
                85                  90                  95      


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met 
            100                 105                 110         


Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr Phe 
    130                 135                 140                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
                165                 170                 175     


Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr 
            180                 185                 190         


Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp Tyr 
        195                 200                 205             


Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala Ser 
    210                 215                 220                 


Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
225                 230                 235                 240 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
                245                 250                 255     


Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly Gly 
            260                 265                 270         


Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val 
    290                 295                 300                 


Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg 
305                 310                 315                 320 


Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val 
                325                 330                 335     


Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe 
            340                 345                 350         


Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln 
        355                 360                 365             


Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val 
    370                 375                 380                 


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
385                 390                 395                 400 


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
                405                 410                 415     


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            420                 425                 430         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        435                 440                 445             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    450                 455                 460                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
465                 470                 475                 480 


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr 
                485                 490                 495     


Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro 
            500                 505                 510         


Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu 
        515                 520                 525             


His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile 
    530                 535                 540                 


Ser Val Gln Glu Arg Gln 
545                 550 


<210>  56
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr 
65                  70                  75                  80  


Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            100                 105                 110         


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                165                 170                 175     


Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser 
        195                 200                 205             


Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr 
    210                 215                 220                 


Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg 
225                 230                 235                 240 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly 
                245                 250                 255     


Tyr Cys Thr Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val 
    290                 295                 300                 


Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg 
305                 310                 315                 320 


Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val 
                325                 330                 335     


Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe 
            340                 345                 350         


Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln 
        355                 360                 365             


Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val 
    370                 375                 380                 


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
385                 390                 395                 400 


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
                405                 410                 415     


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            420                 425                 430         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        435                 440                 445             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    450                 455                 460                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
465                 470                 475                 480 


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr 
                485                 490                 495     


Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro 
            500                 505                 510         


Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu 
        515                 520                 525             


His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile 
    530                 535                 540                 


Ser Val Gln Glu Arg Gln 
545                 550 


<210>  57
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ile 
            20                  25                  30          


Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn 
        35                  40                  45              


Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala 
    50                  55                  60                  


Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr 
65                  70                  75                  80  


Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn 
                85                  90                  95      


Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn 
            100                 105                 110         


Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met 
        115                 120                 125             


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
    130                 135                 140                 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
145                 150                 155                 160 


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
                165                 170                 175     


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
            180                 185                 190         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        195                 200                 205             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    210                 215                 220                 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
225                 230                 235                 240 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
                245                 250                 255     


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
            260                 265                 270         


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
        275                 280                 285             


Val Gln Glu Arg Gln 
    290             


<210>  58
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  58

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Phe 
            20                  25                  30          


Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn 
        35                  40                  45              


Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp 
    50                  55                  60                  


Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile 
65                  70                  75                  80  


Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val 
                85                  90                  95      


Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro Ala 
            100                 105                 110         


Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu 
        115                 120                 125             


Ala Leu Gly Val Phe Cys Phe Ala Arg Ser Lys Arg Ser Arg Leu Leu 
    130                 135                 140                 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
145                 150                 155                 160 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                165                 170                 175     


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
            180                 185                 190         


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
        195                 200                 205             


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
    210                 215                 220                 


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
225                 230                 235                 


<210>  59
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  59

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Tyr Lys Asp Asp Asp Asp Lys Asp Gly 
            20                  25                  30          


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        35                  40                  45              


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    50                  55                  60                  


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
65                  70                  75                  80  


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                85                  90                  95      


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            100                 105                 110         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        115                 120                 125             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    130                 135                 140                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
145                 150                 155                 160 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                165                 170                 175     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            180                 185                 190         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        195                 200                 205             


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    210                 215                 220                 


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
225                 230                 235                 240 


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                245                 250                 255     


Ile Ser Val Gln Glu Arg Gln 
            260             


<210>  60
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  60

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
        35                  40                  45              


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
    50                  55                  60                  


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
65                  70                  75                  80  


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
                85                  90                  95      


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
            100                 105                 110         


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe 
        115                 120                 125             


Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly Val Tyr 
    130                 135                 140                 


Phe Ile Ala Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
145                 150                 155                 160 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                165                 170                 175     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
            180                 185                 190         


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
        195                 200                 205             


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
    210                 215                 220                 


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
225                 230                 235                 240 


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
                245                 250 


<210>  61
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  61

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    50                  55                  60                  


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
65                  70                  75                  80  


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
                85                  90                  95      


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
            100                 105                 110         


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
        115                 120                 125             


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
    130                 135                 140                 


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Glu Gln Lys Leu Ile Ser 
145                 150                 155                 160 


Glu Glu Asp Leu 
                


<210>  62
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser 
            20                  25                  30          


Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn 
        35                  40                  45              


Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn 
    50                  55                  60                  


Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile 
65                  70                  75                  80  


Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp 
                85                  90                  95      


Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His 
            100                 105                 110         


Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro 
        115                 120                 125             


Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro 
    130                 135                 140                 


Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val 
145                 150                 155                 160 


Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu 
                165                 170                 175     


Leu Thr Ala Lys Leu Phe Phe Leu Arg Ser Lys Arg Ser Arg Leu Leu 
            180                 185                 190         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        195                 200                 205             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    210                 215                 220                 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
225                 230                 235                 240 


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
                245                 250                 255     


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
            260                 265                 270         


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
        275                 280                 285         


<210>  63
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Lys Gln 
            20                  25                  30          


Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile 
        35                  40                  45              


Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu 
    50                  55                  60                  


Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu Lys Lys Ser 
65                  70                  75                  80  


Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp 
                85                  90                  95      


Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp 
            100                 105                 110         


Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val 
        115                 120                 125             


Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met 
    130                 135                 140                 


Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
145                 150                 155                 160 


Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu 
                165                 170                 175     


Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Ser 
            180                 185                 190         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        195                 200                 205             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    210                 215                 220                 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
225                 230                 235                 240 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
                245                 250                 255     


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
            260                 265                 270         


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
        275                 280                 285             


Val Gln Glu Arg Gln 
    290             


<210>  64
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ile 
            20                  25                  30          


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
        35                  40                  45              


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
    50                  55                  60                  


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
65                  70                  75                  80  


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
                85                  90                  95      


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
            100                 105                 110         


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
        115                 120                 125             


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
    130                 135                 140                 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
145                 150                 155                 160 


Thr Leu Arg Leu Trp Ser Ser Arg Ser Lys Arg Ser Arg Leu Leu His 
                165                 170                 175     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            180                 185                 190         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        195                 200                 205             


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
    210                 215                 220                 


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
225                 230                 235                 240 


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
                245                 250                 255     


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            260                 265                 270 


<210>  65
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Val Leu Thr 
            20                  25                  30          


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        35                  40                  45              


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    50                  55                  60                  


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
65                  70                  75                  80  


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                85                  90                  95      


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            100                 105                 110         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        115                 120                 125             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    130                 135                 140                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
145                 150                 155                 160 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                165                 170                 175     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            180                 185                 190         


Val Lys Arg Lys Asn Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        195                 200                 205             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    210                 215                 220                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
225                 230                 235                 240 


Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu 
                245                 250                 255     


Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala 
            260                 265                 270         


Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu 
        275                 280                 285             


Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    290                 295                 300     


<210>  66
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser 
            20                  25                  30          


Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn 
        35                  40                  45              


Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn 
    50                  55                  60                  


Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile 
65                  70                  75                  80  


Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp 
                85                  90                  95      


Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His 
            100                 105                 110         


Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro 
        115                 120                 125             


Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro 
    130                 135                 140                 


Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val 
145                 150                 155                 160 


Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu 
                165                 170                 175     


Leu Thr Ala Lys Leu Phe Phe Leu Arg Ser Lys Arg Ser Arg Leu Leu 
            180                 185                 190         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        195                 200                 205             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    210                 215                 220                 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
225                 230                 235                 240 


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
                245                 250                 255     


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
            260                 265                 270         


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Arg 
        275                 280                 285             


Ala Lys Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
    290                 295                 300                 


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
305                 310                 315                 320 


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Tyr Lys 
                325                 330                 335     


Asp Asp Asp Asp Lys Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys 
            340                 345                 350         


Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala 
        355                 360                 365             


Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys 
    370                 375                 380                 


Ile His Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu 
385                 390                 395                 400 


Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                405                 410                 415     


Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg 
            420                 425                 430         


His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro 
        435                 440                 445             


Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys 
    450                 455                 460                 


Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr 
465                 470                 475                 480 


Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile 
                485                 490                 495     


Ile Thr Cys Cys Leu Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            500                 505                 510         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        515                 520                 525             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
    530                 535                 540                 


Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu 
545                 550                 555                 560 


Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala 
                565                 570                 575     


Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu 
            580                 585                 590         


Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
        595                 600                 605 


<210>  67
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ile 
            20                  25                  30          


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
        35                  40                  45              


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
    50                  55                  60                  


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
65                  70                  75                  80  


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
                85                  90                  95      


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
            100                 105                 110         


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
        115                 120                 125             


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
    130                 135                 140                 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
145                 150                 155                 160 


Thr Leu Arg Leu Trp Ser Ser Arg Ser Lys Arg Ser Arg Leu Leu His 
                165                 170                 175     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            180                 185                 190         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        195                 200                 205             


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
    210                 215                 220                 


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
225                 230                 235                 240 


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
                245                 250                 255     


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Arg Ala 
            260                 265                 270         


Lys Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
        275                 280                 285             


Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu 
    290                 295                 300                 


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Tyr Lys Asp 
305                 310                 315                 320 


Asp Asp Asp Lys Val Leu Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
                325                 330                 335     


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            340                 345                 350         


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        355                 360                 365             


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    370                 375                 380                 


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
385                 390                 395                 400 


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                405                 410                 415     


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            420                 425                 430         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        435                 440                 445             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    450                 455                 460                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
465                 470                 475                 480 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ser Lys 
                485                 490                 495     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            500                 505                 510         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        515                 520                 525             


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
    530                 535                 540                 


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
545                 550                 555                 560 


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
                565                 570                 575     


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
            580                 585                 590         


Gln Glu Arg Gln 
        595     


<210>  68
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  68

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Phe 
            20                  25                  30          


Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn 
        35                  40                  45              


Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp 
    50                  55                  60                  


Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile 
65                  70                  75                  80  


Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val 
                85                  90                  95      


Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro Ala 
            100                 105                 110         


Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu 
        115                 120                 125             


Ala Leu Gly Val Phe Cys Phe Ala Arg Ser Lys Arg Ser Arg Leu Leu 
    130                 135                 140                 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
145                 150                 155                 160 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                165                 170                 175     


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
            180                 185                 190         


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
        195                 200                 205             


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
    210                 215                 220                 


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Arg 
225                 230                 235                 240 


Ala Lys Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
                245                 250                 255     


Asp Val Glu Glu Asn Pro Gly Pro Met Gln Ser Gly Thr His Trp Arg 
            260                 265                 270         


Val Leu Gly Leu Cys Leu Leu Ser Val Gly Val Trp Gly Gln Asp Tyr 
        275                 280                 285             


Lys Asp Asp Asp Asp Lys Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
    290                 295                 300                 


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
305                 310                 315                 320 


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
                325                 330                 335     


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
            340                 345                 350         


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
        355                 360                 365             


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
    370                 375                 380                 


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
385                 390                 395                 400 


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
                405                 410                 415     


Leu Leu Leu Val Tyr Tyr Trp Ser Arg Ser Lys Arg Ser Arg Leu Leu 
            420                 425                 430         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        435                 440                 445             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    450                 455                 460                 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
465                 470                 475                 480 


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
                485                 490                 495     


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
            500                 505                 510         


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
        515                 520                 525         


<210>  69
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  69

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
        35                  40                  45              


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
    50                  55                  60                  


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
65                  70                  75                  80  


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
                85                  90                  95      


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
            100                 105                 110         


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe 
        115                 120                 125             


Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly Val Tyr 
    130                 135                 140                 


Phe Ile Ala Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
145                 150                 155                 160 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                165                 170                 175     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
            180                 185                 190         


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
        195                 200                 205             


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
    210                 215                 220                 


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
225                 230                 235                 240 


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Arg Ala Lys Arg Gly Ser 
                245                 250                 255     


Gly Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu 
            260                 265                 270         


Ser Val Gly Val Trp Gly Gln Asp Tyr Lys Asp Asp Asp Asp Lys Asp 
        275                 280                 285             


Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser 
    290                 295                 300                 


Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser 
305                 310                 315                 320 


Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp 
                325                 330                 335     


Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe 
            340                 345                 350         


Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser 
        355                 360                 365             


Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys 
    370                 375                 380                 


Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile 
385                 390                 395                 400 


Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp 
                405                 410                 415     


Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            420                 425                 430         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        435                 440                 445             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys 
    450                 455                 460                 


Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn 
465                 470                 475                 480 


Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu 
                485                 490                 495     


Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser 
            500                 505                 510         


Arg Ile Ser Val Gln Glu Arg Gln 
        515                 520 


<210>  70
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  70

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Phe 
            20                  25                  30          


Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn 
        35                  40                  45              


Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp 
    50                  55                  60                  


Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile 
65                  70                  75                  80  


Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val 
                85                  90                  95      


Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro Ala 
            100                 105                 110         


Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu 
        115                 120                 125             


Ala Leu Gly Val Phe Cys Phe Ala Gly His Glu Thr Gly Arg Leu Ser 
    130                 135                 140                 


Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln 
145                 150                 155                 160 


Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser His Leu Gly Gly Asn 
                165                 170                 175     


Trp Ala Arg Asn Lys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            180                 185                 190         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        195                 200                 205             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys 
    210                 215                 220                 


Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro 
225                 230                 235                 240 


Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala 
                245                 250                 255     


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
            260                 265                 270         


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Arg Ala Lys Arg 
        275                 280                 285             


Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
    290                 295                 300                 


Glu Asn Pro Gly Pro Met Gln Ser Gly Thr His Trp Arg Val Leu Gly 
305                 310                 315                 320 


Leu Cys Leu Leu Ser Val Gly Val Trp Gly Gln Asp Tyr Lys Asp Asp 
                325                 330                 335     


Asp Asp Lys Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro 
            340                 345                 350         


Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln 
        355                 360                 365             


Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly 
    370                 375                 380                 


Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser 
385                 390                 395                 400 


Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr 
                405                 410                 415     


Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg 
            420                 425                 430         


Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala 
        435                 440                 445             


Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu 
    450                 455                 460                 


Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr 
465                 470                 475                 480 


Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg 
                485                 490                 495     


Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln 
            500                 505                 510         


Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile Arg Ser Lys Arg 
        515                 520                 525             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    530                 535                 540                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
545                 550                 555                 560 


Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala 
                565                 570                 575     


Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu 
            580                 585                 590         


Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys 
        595                 600                 605             


Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln 
    610                 615                 620                 


Glu Arg Gln 
625         


<210>  71
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  71

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Phe 
            20                  25                  30          


Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn 
        35                  40                  45              


Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp 
    50                  55                  60                  


Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile 
65                  70                  75                  80  


Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val 
                85                  90                  95      


Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro Ala 
            100                 105                 110         


Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu 
        115                 120                 125             


Ala Leu Gly Val Phe Cys Phe Ala Gly His Glu Thr Gly Arg Leu Ser 
    130                 135                 140                 


Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln 
145                 150                 155                 160 


Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser His Leu Gly Gly Asn 
                165                 170                 175     


Trp Ala Arg Asn Lys Arg Ala Lys Arg Gly Ser Gly Glu Gly Arg Gly 
            180                 185                 190         


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gln 
        195                 200                 205             


Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser Val Gly 
    210                 215                 220                 


Val Trp Gly Gln Asp Tyr Lys Asp Asp Asp Asp Lys Asp Gly Asn Glu 
225                 230                 235                 240 


Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly 
                245                 250                 255     


Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu 
            260                 265                 270         


Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn 
        275                 280                 285             


Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu 
    290                 295                 300                 


Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu 
305                 310                 315                 320 


Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys 
                325                 330                 335     


Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile 
            340                 345                 350         


Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn 
        355                 360                 365             


Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly 
    370                 375                 380                 


Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro 
385                 390                 395                 400 


Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu 
                405                 410                 415     


Asn Gln Arg Arg Ile 
            420     


<210>  72
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  72

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Phe 
            20                  25                  30          


Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn 
        35                  40                  45              


Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp 
    50                  55                  60                  


Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile 
65                  70                  75                  80  


Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val 
                85                  90                  95      


Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro Ala 
            100                 105                 110         


Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu 
        115                 120                 125             


Ala Leu Gly Val Phe Cys Phe Ala Arg Ala Lys Arg Gly Ser Gly Glu 
    130                 135                 140                 


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
145                 150                 155                 160 


Pro Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu 
                165                 170                 175     


Ser Val Gly Val Trp Gly Gln Asp Tyr Lys Asp Asp Asp Asp Lys Asp 
            180                 185                 190         


Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser 
        195                 200                 205             


Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser 
    210                 215                 220                 


Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp 
225                 230                 235                 240 


Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe 
                245                 250                 255     


Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser 
            260                 265                 270         


Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys 
        275                 280                 285             


Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile 
    290                 295                 300                 


Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp 
305                 310                 315                 320 


Ser 
    


<210>  73
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  73

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
        35                  40                  45              


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
    50                  55                  60                  


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
65                  70                  75                  80  


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
                85                  90                  95      


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
            100                 105                 110         


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe 
        115                 120                 125             


Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly Val Tyr 
    130                 135                 140                 


Phe Ile Ala Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys 
145                 150                 155                 160 


Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg 
                165                 170                 175     


Glu Asp Asp Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
            180                 185                 190         


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
        195                 200                 205             


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
    210                 215                 220                 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
225                 230                 235                 240 


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
                245                 250                 255     


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
            260                 265                 270         


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
        275                 280                 285             


Ile Ser Val Gln Glu Arg Gln Arg Ala Lys Arg Gly Ser Gly Glu Gly 
    290                 295                 300                 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
305                 310                 315                 320 


Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
                325                 330                 335     


Val Gly Val Trp Gly Gln Asp Tyr Lys Asp Asp Asp Asp Lys Asp Gly 
            340                 345                 350         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        355                 360                 365             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    370                 375                 380                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
385                 390                 395                 400 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                405                 410                 415     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            420                 425                 430         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        435                 440                 445             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    450                 455                 460                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
465                 470                 475                 480 


Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
                485                 490                 495     


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            500                 505                 510         


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        515                 520                 525             


Gly Leu Asn Gln Arg Arg Ile Arg Ser Lys Arg Ser Arg Leu Leu His 
    530                 535                 540                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
545                 550                 555                 560 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                565                 570                 575     


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
            580                 585                 590         


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
        595                 600                 605             


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
    610                 615                 620                 


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
625                 630                 635             


<210>  74
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  74

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
        35                  40                  45              


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
    50                  55                  60                  


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
65                  70                  75                  80  


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
                85                  90                  95      


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
            100                 105                 110         


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe 
        115                 120                 125             


Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly Val Tyr 
    130                 135                 140                 


Phe Ile Ala Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys 
145                 150                 155                 160 


Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg 
                165                 170                 175     


Glu Asp Asp Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
            180                 185                 190         


Arg Ala Lys Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
        195                 200                 205             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gln Ser Gly Thr His Trp 
    210                 215                 220                 


Arg Val Leu Gly Leu Cys Leu Leu Ser Val Gly Val Trp Gly Gln Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys Asp Gly Asn Glu Glu Met Gly Gly Ile 
                245                 250                 255     


Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu 
            260                 265                 270         


Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp 
        275                 280                 285             


Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu 
    290                 295                 300                 


Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr 
305                 310                 315                 320 


Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr 
                325                 330                 335     


Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val 
            340                 345                 350         


Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly 
        355                 360                 365             


Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala 
    370                 375                 380                 


Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln 
385                 390                 395                 400 


Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile 
                405                 410                 415     


Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
            420                 425                 430         


<210>  75
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  75

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
        35                  40                  45              


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
    50                  55                  60                  


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
65                  70                  75                  80  


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
                85                  90                  95      


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
            100                 105                 110         


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe 
        115                 120                 125             


Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly Val Tyr 
    130                 135                 140                 


Phe Ile Ala Arg Ala Lys Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu 
145                 150                 155                 160 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gln Ser Gly 
                165                 170                 175     


Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser Val Gly Val Trp 
            180                 185                 190         


Gly Gln Asp Tyr Lys Asp Asp Asp Asp Lys Asp Gly Asn Glu Glu Met 
        195                 200                 205             


Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr 
    210                 215                 220                 


Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln 
225                 230                 235                 240 


His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly 
                245                 250                 255     


Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln 
            260                 265                 270         


Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala 
        275                 280                 285             


Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu 
    290                 295                 300                 


Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile 
305                 310                 315                 320 


Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
                325                 330         


<210>  76
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  76

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
                165                 170                 175     


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
            180                 185                 190         


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val 
        195                 200                 205             


Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln 
    210                 215                 220                 


Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro 
225                 230                 235                 240 


Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly 
                245                 250                 255     


Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu 
        275         


<210>  77

<400>  77
000

<210>  78
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  78

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                165                 170                 


<210>  79
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  79

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    50                  55                  60      


<210>  80
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  80

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                165                 170                 175     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            180                 185                 190         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        195                 200                 205             


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    210                 215                 220                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
225                 230                 235                 240 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                245                 250                 255     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            260                 265                 270         


Ala Leu Pro Pro Arg Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        275                 280                 285             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    290                 295                 300                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys 
305                 310                 315                 320 


Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro 
                325                 330                 335     


Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala 
            340                 345                 350         


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
        355                 360                 365             


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Glu Gln Lys Leu 
    370                 375                 380                 


Ile Ser Glu Glu Asp Leu 
385                 390 


<210>  81
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  81

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                165                 170                 175     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            180                 185                 190         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        195                 200                 205             


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    210                 215                 220                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
225                 230                 235                 240 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                245                 250                 255     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            260                 265                 270         


Ala Leu Pro Pro Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
        275                 280                 285         


<210>  82
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  82

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    50                  55                  60                  


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
65                  70                  75                  80  


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
                85                  90                  95      


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
            100                 105                 110         


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
        115                 120                 125             


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
    130                 135                 140                 


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Arg Val Lys Phe Ser Arg 
145                 150                 155                 160 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                165                 170                 175     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            180                 185                 190         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
        195                 200                 205             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    210                 215                 220                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
225                 230                 235                 240 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                245                 250                 255     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Val Lys Phe Ser 
            260                 265                 270         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        275                 280                 285             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    290                 295                 300                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
305                 310                 315                 320 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                325                 330                 335     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            340                 345                 350         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        355                 360                 365             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Gln Lys Leu 
    370                 375                 380                 


Ile Ser Glu Glu Asp Leu 
385                 390 


<210>  83
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  83

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    50                  55                  60                  


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
65                  70                  75                  80  


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
                85                  90                  95      


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
            100                 105                 110         


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
        115                 120                 125             


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
    130                 135                 140                 


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Arg Val Lys Phe Ser Arg 
145                 150                 155                 160 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                165                 170                 175     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            180                 185                 190         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
        195                 200                 205             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    210                 215                 220                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
225                 230                 235                 240 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                245                 250                 255     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Gln Lys Leu Ile 
            260                 265                 270         


Ser Glu Glu Asp Leu 
        275         


<210>  84
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  84

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Val Ile His Val 
        35                  40                  45              


Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly His Asn Val 
    50                  55                  60                  


Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln Lys Glu Lys 
65                  70                  75                  80  


Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile Trp Pro Glu 
                85                  90                  95      


Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu Ser Ile Val 
            100                 105                 110         


Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu Cys Val Val 
        115                 120                 125             


Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu Ala Glu Val 
    130                 135                 140                 


Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe 
145                 150                 155                 160 


Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys Ser Thr Ser Gly 
                165                 170                 175     


Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn Gly Glu Glu Leu 
            180                 185                 190         


Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu Thr Glu Leu Tyr 
        195                 200                 205             


Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr Asn His Ser Phe 
    210                 215                 220                 


Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn Gln Thr Phe Asn 
225                 230                 235                 240 


Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn Leu Leu Pro Ser 
                245                 250                 255     


Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile Cys Cys 
            260                 265                 270         


Leu 
    


<210>  85
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  85

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro Glu Gln Lys 
            500                 505                 510         


Leu Ile Ser Glu Glu Asp Leu 
        515                 


<210>  86
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  86

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Phe Gln Pro Gln Pro Glu Gln Lys 
            500                 505                 510         


Leu Ile Ser Glu Glu Asp Leu 
        515                 


<210>  87
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  87

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Val Ile His Val 
        35                  40                  45              


Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly His Asn Val 
    50                  55                  60                  


Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln Lys Glu Lys 
65                  70                  75                  80  


Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile Trp Pro Glu 
                85                  90                  95      


Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu Ser Ile Val 
            100                 105                 110         


Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu Cys Val Val 
        115                 120                 125             


Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu Ala Glu Val 
    130                 135                 140                 


Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe 
145                 150                 155                 160 


Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys Ser Thr Ser Gly 
                165                 170                 175     


Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn Gly Glu Glu Leu 
            180                 185                 190         


Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu Thr Glu Leu Tyr 
        195                 200                 205             


Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr Asn His Ser Phe 
    210                 215                 220                 


Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn Gln Thr Phe Asn 
225                 230                 235                 240 


Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn Leu Leu Pro Ser 
                245                 250                 255     


Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile Cys Cys 
            260                 265                 270         


Leu Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
        275                 280                 285             


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
    290                 295                 300                 


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
305                 310                 315                 320 


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
                325                 330                 335     


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
            340                 345                 350         


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
        355                 360                 365             


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
    370                 375                 380                 


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
385                 390                 395                 400 


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
                405                 410                 415     


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
            420                 425                 430         


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
        435                 440                 445             


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
    450                 455                 460                 


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
465                 470                 475                 480 


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
                485                 490                 495     


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
            500                 505                 510         


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
        515                 520                 525             


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
    530                 535                 540                 


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
545                 550                 555                 560 


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
                565                 570                 575     


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
            580                 585                 590         


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
        595                 600                 605             


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
    610                 615                 620                 


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
625                 630                 635                 640 


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
                645                 650                 655     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
            660                 665                 670         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
        675                 680                 685             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
    690                 695                 700                 


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
705                 710                 715                 720 


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
                725                 730                 735     


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
            740                 745                 750         


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
        755                 760                 765             


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
    770                 775                 780     


<210>  88
<211>  884
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  88

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Val Ile His Val 
        35                  40                  45              


Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly His Asn Val 
    50                  55                  60                  


Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln Lys Glu Lys 
65                  70                  75                  80  


Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile Trp Pro Glu 
                85                  90                  95      


Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu Ser Ile Val 
            100                 105                 110         


Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu Cys Val Val 
        115                 120                 125             


Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu Ala Glu Val 
    130                 135                 140                 


Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe 
145                 150                 155                 160 


Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys Ser Thr Ser Gly 
                165                 170                 175     


Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn Gly Glu Glu Leu 
            180                 185                 190         


Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu Thr Glu Leu Tyr 
        195                 200                 205             


Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr Asn His Ser Phe 
    210                 215                 220                 


Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn Gln Thr Phe Asn 
225                 230                 235                 240 


Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn Leu Leu Pro Ser 
                245                 250                 255     


Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile Cys Cys 
            260                 265                 270         


Leu Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
        275                 280                 285             


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
    290                 295                 300                 


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
305                 310                 315                 320 


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
                325                 330                 335     


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
            340                 345                 350         


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
        355                 360                 365             


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
    370                 375                 380                 


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
385                 390                 395                 400 


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
                405                 410                 415     


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
            420                 425                 430         


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
        435                 440                 445             


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
    450                 455                 460                 


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
465                 470                 475                 480 


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
                485                 490                 495     


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
            500                 505                 510         


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
        515                 520                 525             


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
    530                 535                 540                 


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
545                 550                 555                 560 


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
                565                 570                 575     


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
            580                 585                 590         


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
        595                 600                 605             


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
    610                 615                 620                 


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
625                 630                 635                 640 


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
                645                 650                 655     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
            660                 665                 670         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
        675                 680                 685             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
    690                 695                 700                 


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
705                 710                 715                 720 


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
                725                 730                 735     


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
            740                 745                 750         


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
        755                 760                 765             


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro Arg Ser Lys 
    770                 775                 780                 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
785                 790                 795                 800 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
                805                 810                 815     


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
            820                 825                 830         


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
        835                 840                 845             


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
    850                 855                 860                 


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
865                 870                 875                 880 


Gln Glu Arg Gln 
                


<210>  89
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  89

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Val Ile His Val 
        35                  40                  45              


Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly His Asn Val 
    50                  55                  60                  


Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln Lys Glu Lys 
65                  70                  75                  80  


Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile Trp Pro Glu 
                85                  90                  95      


Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu Ser Ile Val 
            100                 105                 110         


Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu Cys Val Val 
        115                 120                 125             


Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu Ala Glu Val 
    130                 135                 140                 


Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe 
145                 150                 155                 160 


Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys Ser Thr Ser Gly 
                165                 170                 175     


Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn Gly Glu Glu Leu 
            180                 185                 190         


Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu Thr Glu Leu Tyr 
        195                 200                 205             


Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr Asn His Ser Phe 
    210                 215                 220                 


Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn Gln Thr Phe Asn 
225                 230                 235                 240 


Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn Leu Leu Pro Ser 
                245                 250                 255     


Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile Cys Cys 
            260                 265                 270         


Leu Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
        275                 280                 285             


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
    290                 295                 300                 


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
305                 310                 315                 320 


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
                325                 330                 335     


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
            340                 345                 350         


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
        355                 360                 365             


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
    370                 375                 380                 


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
385                 390                 395                 400 


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
                405                 410                 415     


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
            420                 425                 430         


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
        435                 440                 445             


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
    450                 455                 460                 


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
465                 470                 475                 480 


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
                485                 490                 495     


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
            500                 505                 510         


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
        515                 520                 525             


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
    530                 535                 540                 


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
545                 550                 555                 560 


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
                565                 570                 575     


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
            580                 585                 590         


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
        595                 600                 605             


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
    610                 615                 620                 


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
625                 630                 635                 640 


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
                645                 650                 655     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
            660                 665                 670         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
        675                 680                 685             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
    690                 695                 700                 


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
705                 710                 715                 720 


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
                725                 730                 735     


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
            740                 745                 750         


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
        755                 760                 765             


Phe Phe Thr Ala Thr Glu Gly Gln Phe Gln Pro Gln Pro 
    770                 775                 780     


<210>  90
<211>  884
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  90

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Val Ile His Val 
        35                  40                  45              


Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly His Asn Val 
    50                  55                  60                  


Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln Lys Glu Lys 
65                  70                  75                  80  


Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile Trp Pro Glu 
                85                  90                  95      


Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu Ser Ile Val 
            100                 105                 110         


Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu Cys Val Val 
        115                 120                 125             


Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu Ala Glu Val 
    130                 135                 140                 


Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe 
145                 150                 155                 160 


Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys Ser Thr Ser Gly 
                165                 170                 175     


Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn Gly Glu Glu Leu 
            180                 185                 190         


Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu Thr Glu Leu Tyr 
        195                 200                 205             


Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr Asn His Ser Phe 
    210                 215                 220                 


Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn Gln Thr Phe Asn 
225                 230                 235                 240 


Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn Leu Leu Pro Ser 
                245                 250                 255     


Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile Cys Cys 
            260                 265                 270         


Leu Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
        275                 280                 285             


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
    290                 295                 300                 


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
305                 310                 315                 320 


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
                325                 330                 335     


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
            340                 345                 350         


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
        355                 360                 365             


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
    370                 375                 380                 


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
385                 390                 395                 400 


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
                405                 410                 415     


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
            420                 425                 430         


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
        435                 440                 445             


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
    450                 455                 460                 


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
465                 470                 475                 480 


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
                485                 490                 495     


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
            500                 505                 510         


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
        515                 520                 525             


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
    530                 535                 540                 


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
545                 550                 555                 560 


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
                565                 570                 575     


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
            580                 585                 590         


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
        595                 600                 605             


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
    610                 615                 620                 


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
625                 630                 635                 640 


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
                645                 650                 655     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
            660                 665                 670         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
        675                 680                 685             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
    690                 695                 700                 


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
705                 710                 715                 720 


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
                725                 730                 735     


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
            740                 745                 750         


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
        755                 760                 765             


Phe Phe Thr Ala Thr Glu Gly Gln Phe Gln Pro Gln Pro Arg Ser Lys 
    770                 775                 780                 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
785                 790                 795                 800 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
                805                 810                 815     


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
            820                 825                 830         


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
        835                 840                 845             


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
    850                 855                 860                 


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
865                 870                 875                 880 


Gln Glu Arg Gln 
                


<210>  91
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  91

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu Pro 
        35                  40                  45              


Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu Pro 
    50                  55                  60                  


Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly Ile 
65                  70                  75                  80  


Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr Pro 
                85                  90                  95      


Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro Ile 
            100                 105                 110         


Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser 
        115                 120                 125             


Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu 
    130                 135                 140                 


Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp Gly 
145                 150                 155                 160 


Pro Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro Ala 
                165                 170                 175     


Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly Tyr 
            180                 185                 190         


Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala Pro 
        195                 200                 205             


Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe Ser 
    210                 215                 220                 


Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser 
225                 230                 235                 240 


Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln 
                245                 250                 255     


Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser Ser 
            260                 265                 270         


Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu Asn 
        275                 280                 285             


Leu Gln Glu Leu Asn 
    290             


<210>  92
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  92

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu Pro 
        35                  40                  45              


Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu Pro 
    50                  55                  60                  


Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly Ile 
65                  70                  75                  80  


Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr Pro 
                85                  90                  95      


Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro Ile 
            100                 105                 110         


Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser 
        115                 120                 125             


Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu 
    130                 135                 140                 


Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp Gly 
145                 150                 155                 160 


Pro Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro Ala 
                165                 170                 175     


Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly Tyr 
            180                 185                 190         


Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala Pro 
        195                 200                 205             


Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe Ser 
    210                 215                 220                 


Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser 
225                 230                 235                 240 


Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln 
                245                 250                 255     


Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser Ser 
            260                 265                 270         


Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu Asn 
        275                 280                 285             


Leu Gln Glu Leu Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
    290                 295                 300                 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
305                 310                 315                 320 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys 
                325                 330                 335     


Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro 
            340                 345                 350         


Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala 
        355                 360                 365             


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
    370                 375                 380                 


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
385                 390                 395     


<210>  93
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  93

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu 
        35                  40                  45              


Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys 
    50                  55                  60                  


Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr 
65                  70                  75                  80  


Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu 
                85                  90                  95      


Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu 
            100                 105                 110         


Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val 
        115                 120                 125             


Gln Leu Leu Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu 
    130                 135                 140                 


Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser 
145                 150                 155                 160 


Pro Ser Val Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly 
                165                 170                 175     


Lys Thr Leu Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp 
            180                 185                 190         


Thr Cys Thr Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp 
        195                 200                 205             


Ile Val Val Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys 
    210                 215                 220                 


Glu Gly Glu Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu 
225                 230                 235                 240 


Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser 
                245                 250                 255     


Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser 
            260                 265                 270         


Val Lys Arg Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu 
        275                 280                 285             


Pro Leu His Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser 
    290                 295                 300                 


Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln 
305                 310                 315                 320 


Glu Val Asn Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu 
                325                 330                 335     


Thr Cys Glu Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu 
            340                 345                 350         


Lys Leu Glu Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val 
        355                 360                 365             


Trp Val Leu Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp 
    370                 375                 380                 


Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
385                 390                 395                 400 


Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala 
                405                 410                 415     


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
            420                 425                 430         


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
        435                 440                 445             


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
    450                 455                 460                 


Cys Ser Pro Ile 
465             


<210>  94
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  94

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu 
        35                  40                  45              


Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys 
    50                  55                  60                  


Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr 
65                  70                  75                  80  


Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu 
                85                  90                  95      


Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu 
            100                 105                 110         


Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val 
        115                 120                 125             


Gln Leu Leu Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu 
    130                 135                 140                 


Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser 
145                 150                 155                 160 


Pro Ser Val Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly 
                165                 170                 175     


Lys Thr Leu Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp 
            180                 185                 190         


Thr Cys Thr Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp 
        195                 200                 205             


Ile Val Val Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys 
    210                 215                 220                 


Glu Gly Glu Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu 
225                 230                 235                 240 


Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser 
                245                 250                 255     


Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser 
            260                 265                 270         


Val Lys Arg Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu 
        275                 280                 285             


Pro Leu His Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser 
    290                 295                 300                 


Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln 
305                 310                 315                 320 


Glu Val Asn Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu 
                325                 330                 335     


Thr Cys Glu Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu 
            340                 345                 350         


Lys Leu Glu Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val 
        355                 360                 365             


Trp Val Leu Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp 
    370                 375                 380                 


Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
385                 390                 395                 400 


Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala 
                405                 410                 415     


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
            420                 425                 430         


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
        435                 440                 445             


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
    450                 455                 460                 


Cys Ser Pro Ile Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
465                 470                 475                 480 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                485                 490                 495     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val 
            500                 505                 510         


Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln 
        515                 520                 525             


Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro 
    530                 535                 540                 


Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly 
545                 550                 555                 560 


Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
                565                 570     


<210>  95
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  95

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser 
            20                  25                  30          


Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu Thr 
        35                  40                  45              


Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly Cys 
    50                  55                  60                  


Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe Leu 
65                  70                  75                  80  


Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp Thr 
                85                  90                  95      


Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr Leu 
            100                 105                 110         


Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala Leu 
        115                 120                 125             


Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro 
    130                 135                 140                 


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
145                 150                 155                 160 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                165                 170                 175     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            180                 185                 190         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        195                 200                 205             


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
    210                 215                 220                 


Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu 
225                 230                 235                 240 


Ser Ala Arg Tyr Val Arg Ala Lys Arg Gly Ser Gly Glu Gly Arg Gly 
                245                 250                 255     


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg 
            260                 265                 270         


Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu His Gly 
        275                 280                 285             


Asn Ser Val Asp Tyr Lys Asp Asp Asp Asp Lys Leu Gln Gln Thr Pro 
    290                 295                 300                 


Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val Met Leu Ser Cys Glu 
305                 310                 315                 320 


Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg 
                325                 330                 335     


Gln Ala Pro Ser Ser Asp Ser His His Glu Phe Leu Ala Leu Trp Asp 
            340                 345                 350         


Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val Glu Gln Glu Lys Ile 
        355                 360                 365             


Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu Asn Leu Thr Ser Val 
    370                 375                 380                 


Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met Ile Val Gly Ser Pro 
385                 390                 395                 400 


Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser Val Val Asp Phe Leu 
                405                 410                 415     


Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr Leu Lys Lys Arg Val 
            420                 425                 430         


Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro 
        435                 440                 445             


Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser 
    450                 455                 460                 


Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu 
465                 470                 475                 480 


Arg Phe Met Lys Gln Phe Tyr Lys 
                485             


<210>  96
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  96

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser 
            20                  25                  30          


Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu Thr 
        35                  40                  45              


Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly Cys 
    50                  55                  60                  


Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe Leu 
65                  70                  75                  80  


Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp Thr 
                85                  90                  95      


Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr Leu 
            100                 105                 110         


Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala Leu 
        115                 120                 125             


Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro 
    130                 135                 140                 


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
145                 150                 155                 160 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                165                 170                 175     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            180                 185                 190         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        195                 200                 205             


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
    210                 215                 220                 


Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu 
225                 230                 235                 240 


Ser Ala Arg Tyr Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
                245                 250                 255     


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
            260                 265                 270         


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys 
        275                 280                 285             


Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro 
    290                 295                 300                 


Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala 
305                 310                 315                 320 


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
                325                 330                 335     


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Arg Ala Lys Arg 
            340                 345                 350         


Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
        355                 360                 365             


Glu Asn Pro Gly Pro Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala 
    370                 375                 380                 


Gln Leu Thr Val Leu His Gly Asn Ser Val Asp Tyr Lys Asp Asp Asp 
385                 390                 395                 400 


Asp Lys Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys 
                405                 410                 415     


Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg 
            420                 425                 430         


Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His 
        435                 440                 445             


Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu 
    450                 455                 460                 


Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe 
465                 470                 475                 480 


Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe 
                485                 490                 495     


Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln 
            500                 505                 510         


Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys 
        515                 520                 525             


Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln 
    530                 535                 540                 


Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly 
545                 550                 555                 560 


Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys 
                565                 570                 575     


Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys Arg 
            580                 585                 590         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        595                 600                 605             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    610                 615                 620                 


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr 
625                 630                 635                 640 


Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro 
                645                 650                 655     


Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu 
            660                 665                 670         


His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile 
        675                 680                 685             


Ser Val Gln Glu Arg Gln 
    690                 


<210>  97
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  97

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
        35                  40                  45              


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
    50                  55                  60                  


Leu Glu Phe Ile Leu Ala Ala His Asn Cys Thr Tyr Gly Cys Thr Gly 
65                  70                  75                  80  


Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
                85                  90                  95      


Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu 
            100                 105                 110         


Gly Ile Gly Leu Phe Met Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        115                 120                 125             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    130                 135                 140                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
145                 150                 155                 160 


Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu 
                165                 170                 175     


Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala 
            180                 185                 190         


Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu 
        195                 200                 205             


Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    210                 215                 220     


<210>  98
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  98

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
        35                  40                  45              


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
    50                  55                  60                  


Leu Glu Phe Ile Leu Ala Ala His Phe Trp Val Leu Val Val Val Gly 
65                  70                  75                  80  


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                85                  90                  95      


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            100                 105                 110         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        115                 120                 125             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
    130                 135                 140                 


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
145                 150                 155                 160 


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
                165                 170                 175     


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
            180                 185                 190         


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
        195                 200         


<210>  99
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  99

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu 
            20                  25                  30          


Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser 
        35                  40                  45              


Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu Asn Cys Thr Tyr 
    50                  55                  60                  


Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys 
65                  70                  75                  80  


Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu 
                85                  90                  95      


Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Ser Lys Arg Ser Arg 
            100                 105                 110         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        115                 120                 125             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    130                 135                 140                 


Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His 
145                 150                 155                 160 


Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly 
                165                 170                 175     


Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro 
            180                 185                 190         


Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg 
        195                 200                 205             


Gln 
    


<210>  100
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  100

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu 
            20                  25                  30          


Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser 
        35                  40                  45              


Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu Phe Trp Val Leu 
    50                  55                  60                  


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
65                  70                  75                  80  


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
                85                  90                  95      


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            100                 105                 110         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120                 125             


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
    130                 135                 140                 


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
145                 150                 155                 160 


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
                165                 170                 175     


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            180                 185                 190 


<210>  101
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  101

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Thr Gln His Lys Val Leu Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln 
        35                  40                  45              


Lys Lys Val Glu Gln Leu Ser Arg Glu Leu Ser Thr Asn Cys Thr Tyr 
    50                  55                  60                  


Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys 
65                  70                  75                  80  


Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu 
                85                  90                  95      


Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Ser Lys Arg Ser Arg 
            100                 105                 110         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        115                 120                 125             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    130                 135                 140                 


Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His 
145                 150                 155                 160 


Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly 
                165                 170                 175     


Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro 
            180                 185                 190         


Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg 
        195                 200                 205             


Gln 
    


<210>  102
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  102

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Thr Gln His Lys Val Leu Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln 
        35                  40                  45              


Lys Lys Val Glu Gln Leu Ser Arg Glu Leu Ser Thr Phe Trp Val Leu 
    50                  55                  60                  


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
65                  70                  75                  80  


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
                85                  90                  95      


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            100                 105                 110         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120                 125             


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
    130                 135                 140                 


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
145                 150                 155                 160 


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
                165                 170                 175     


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            180                 185                 190 


<210>  103
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  103

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Glu Gln Lys Leu Ile Ser Glu Glu 
            20                  25                  30          


Asp Leu Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu 
        35                  40                  45              


Thr Gln Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met 
    50                  55                  60                  


Phe Asn Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val 
65                  70                  75                  80  


Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala 
                85                  90                  95      


Gly Tyr Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu 
            100                 105                 110         


Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala 
        115                 120                 125             


Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu 
    130                 135                 140                 


Leu Pro Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe 
145                 150                 155                 160 


Ser Asn Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp 
                165                 170                 175     


Ile Val Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn 
            180                 185                 190         


His Leu Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser 
        195                 200                 205             


Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile 
    210                 215                 220                 


Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp 
225                 230                 235                 240 


Cys Cys His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser 
                245                 250                 255     


Asp Cys Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp 
            260                 265                 270         


Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp 
        275                 280                 285             


Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys 
    290                 295                 300                 


Cys Pro Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala 
305                 310                 315                 320 


Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys 
                325                 330                 335     


Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile 
            340                 345                 350         


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
        355                 360                 365             


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
    370                 375                 380                 


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
385                 390                 395                 400 


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
                405                 410                 415     


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
            420                 425                 430         


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
        435                 440                 445             


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
    450                 455                 460                 


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
465                 470                 475                 480 


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
                485                 490                 495     


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
            500                 505                 510         


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
        515                 520                 525             


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
    530                 535                 540                 


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
545                 550                 555                 560 


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
                565                 570                 575     


Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys 
            580                 585                 590         


Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly 
        595                 600                 605             


Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly 
    610                 615                 620                 


His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly 
625                 630                 635                 640 


Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
                645                 650                 655     


Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu 
            660                 665                 670         


Gly Ile Gly Leu Phe Met Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        675                 680                 685             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    690                 695                 700                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
705                 710                 715                 720 


Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu 
                725                 730                 735     


Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala 
            740                 745                 750         


Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu 
        755                 760                 765             


Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    770                 775                 780     


<210>  104
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  104

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Glu Gln Lys Leu Ile Ser Glu Glu 
            20                  25                  30          


Asp Leu Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly 
        35                  40                  45              


Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser 
    50                  55                  60                  


Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg 
65                  70                  75                  80  


Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu 
                85                  90                  95      


Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His 
            100                 105                 110         


Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly 
        115                 120                 125             


Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys 
    130                 135                 140                 


Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val 
145                 150                 155                 160 


Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn 
                165                 170                 175     


Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn 
            180                 185                 190         


Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu 
        195                 200                 205             


Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Ser Lys 
    210                 215                 220                 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
225                 230                 235                 240 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
                245                 250                 255     


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
            260                 265                 270         


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
        275                 280                 285             


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
    290                 295                 300                 


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
305                 310                 315                 320 


Gln Glu Arg Gln 
                


<210>  105
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  105

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Glu Gln Lys Leu Ile Ser Glu Glu 
            20                  25                  30          


Asp Leu Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
        35                  40                  45              


Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly 
    50                  55                  60                  


Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
65                  70                  75                  80  


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                85                  90                  95      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            100                 105                 110         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro 
        115                 120                 125             


Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe 
    130                 135                 140                 


Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr 
145                 150                 155                 160 


Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg 
                165                 170                 175     


Ile Ser Val Gln Glu Arg Gln 
            180             


<210>  106
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  106

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
        35                  40                  45              


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
    50                  55                  60                  


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
65                  70                  75                  80  


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
                85                  90                  95      


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
            100                 105                 110         


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
        115                 120                 125             


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
    130                 135                 140                 


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
145                 150                 155                 160 


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
                165                 170                 175     


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
            180                 185                 190         


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
        195                 200                 205             


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
    210                 215                 220                 


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
225                 230                 235                 240 


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
                245                 250                 255     


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
            260                 265                 270         


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
        275                 280                 285             


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
    290                 295                 300                 


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
305                 310                 315                 320 


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
                325                 330                 335     


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
            340                 345                 350         


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
        355                 360                 365             


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
    370                 375                 380                 


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
385                 390                 395                 400 


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
                405                 410                 415     


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
            420                 425                 430         


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
        435                 440                 445             


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
    450                 455                 460                 


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
465                 470                 475                 480 


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
                485                 490                 495     


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
            500                 505                 510         


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
        515                 520                 525             


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
    530                 535                 540                 


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
545                 550                 555                 560 


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
                565                 570                 575     


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
            580                 585                 590         


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
        595                 600                 605             


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
    610                 615                 620                 


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
625                 630                 635                 640 


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
                645                 650                 655     


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu 
            660                 665                 670         


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Arg Ser Lys 
        675                 680                 685             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    690                 695                 700                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
705                 710                 715                 720 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                725                 730                 735     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            740                 745                 750         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        755                 760                 765             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    770                 775                 780                 


Gln Glu Arg Gln 
785             


<210>  107
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  107

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
        35                  40                  45              


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
    50                  55                  60                  


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
65                  70                  75                  80  


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
                85                  90                  95      


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
            100                 105                 110         


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
        115                 120                 125             


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
    130                 135                 140                 


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
145                 150                 155                 160 


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
                165                 170                 175     


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
            180                 185                 190         


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
        195                 200                 205             


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
    210                 215                 220                 


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
225                 230                 235                 240 


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
                245                 250                 255     


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
            260                 265                 270         


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
        275                 280                 285             


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
    290                 295                 300                 


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
305                 310                 315                 320 


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
                325                 330                 335     


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
            340                 345                 350         


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
        355                 360                 365             


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
    370                 375                 380                 


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
385                 390                 395                 400 


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
                405                 410                 415     


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
            420                 425                 430         


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
        435                 440                 445             


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
    450                 455                 460                 


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
465                 470                 475                 480 


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
                485                 490                 495     


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
            500                 505                 510         


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
        515                 520                 525             


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
    530                 535                 540                 


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
545                 550                 555                 560 


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
                565                 570                 575     


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
            580                 585                 590         


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
        595                 600                 605             


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
    610                 615                 620                 


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
625                 630                 635                 640 


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
                645                 650                 655     


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Glu Gly Ile Leu 
            660                 665                 670         


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Arg Ser Lys 
        675                 680                 685             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    690                 695                 700                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
705                 710                 715                 720 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                725                 730                 735     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            740                 745                 750         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        755                 760                 765             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    770                 775                 780                 


Gln Glu Arg Gln 
785             


<210>  108
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  108

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
        35                  40                  45              


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
    50                  55                  60                  


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
65                  70                  75                  80  


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
                85                  90                  95      


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
            100                 105                 110         


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
        115                 120                 125             


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
    130                 135                 140                 


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
145                 150                 155                 160 


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
                165                 170                 175     


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
            180                 185                 190         


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
        195                 200                 205             


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
    210                 215                 220                 


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
225                 230                 235                 240 


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
                245                 250                 255     


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
            260                 265                 270         


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
        275                 280                 285             


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
    290                 295                 300                 


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
305                 310                 315                 320 


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
                325                 330                 335     


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
            340                 345                 350         


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
        355                 360                 365             


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
    370                 375                 380                 


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
385                 390                 395                 400 


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
                405                 410                 415     


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
            420                 425                 430         


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
        435                 440                 445             


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
    450                 455                 460                 


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
465                 470                 475                 480 


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
                485                 490                 495     


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
            500                 505                 510         


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
        515                 520                 525             


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
    530                 535                 540                 


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
545                 550                 555                 560 


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
                565                 570                 575     


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
            580                 585                 590         


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
        595                 600                 605             


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
    610                 615                 620                 


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
625                 630                 635                 640 


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
                645                 650                 655     


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Asp Ile Leu 
            660                 665                 670         


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Arg Ser Lys 
        675                 680                 685             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    690                 695                 700                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
705                 710                 715                 720 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                725                 730                 735     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            740                 745                 750         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        755                 760                 765             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    770                 775                 780                 


Gln Glu Arg Gln 
785             


<210>  109
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  109

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
        35                  40                  45              


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
    50                  55                  60                  


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
65                  70                  75                  80  


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
                85                  90                  95      


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
            100                 105                 110         


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
        115                 120                 125             


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
    130                 135                 140                 


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
145                 150                 155                 160 


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
                165                 170                 175     


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
            180                 185                 190         


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
        195                 200                 205             


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
    210                 215                 220                 


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
225                 230                 235                 240 


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
                245                 250                 255     


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
            260                 265                 270         


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
        275                 280                 285             


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
    290                 295                 300                 


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
305                 310                 315                 320 


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
                325                 330                 335     


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
            340                 345                 350         


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
        355                 360                 365             


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
    370                 375                 380                 


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
385                 390                 395                 400 


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
                405                 410                 415     


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
            420                 425                 430         


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
        435                 440                 445             


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
    450                 455                 460                 


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
465                 470                 475                 480 


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
                485                 490                 495     


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
            500                 505                 510         


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
        515                 520                 525             


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
    530                 535                 540                 


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
545                 550                 555                 560 


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
                565                 570                 575     


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
            580                 585                 590         


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
        595                 600                 605             


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
    610                 615                 620                 


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
625                 630                 635                 640 


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
                645                 650                 655     


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Arg Ile Leu 
            660                 665                 670         


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Arg Ser Lys 
        675                 680                 685             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    690                 695                 700                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
705                 710                 715                 720 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                725                 730                 735     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            740                 745                 750         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        755                 760                 765             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    770                 775                 780                 


Gln Glu Arg Gln 
785             


<210>  110
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  110

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        35                  40                  45              


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    50                  55                  60                  


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
65                  70                  75                  80  


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                85                  90                  95      


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            100                 105                 110         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        115                 120                 125             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    130                 135                 140                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
145                 150                 155                 160 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                165                 170                 175     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            180                 185                 190         


Ile Leu Ile Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        195                 200                 205             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    210                 215                 220                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
225                 230                 235                 240 


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
                245                 250                 255     


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
            260                 265                 270         


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
        275                 280                 285             


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    290                 295             


<210>  111
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  111

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        35                  40                  45              


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    50                  55                  60                  


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
65                  70                  75                  80  


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                85                  90                  95      


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            100                 105                 110         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        115                 120                 125             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    130                 135                 140                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
145                 150                 155                 160 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                165                 170                 175     


Ala Val Glu Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            180                 185                 190         


Ile Leu Ile Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        195                 200                 205             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    210                 215                 220                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
225                 230                 235                 240 


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
                245                 250                 255     


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
            260                 265                 270         


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
        275                 280                 285             


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    290                 295             


<210>  112
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  112

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        35                  40                  45              


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    50                  55                  60                  


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
65                  70                  75                  80  


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                85                  90                  95      


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            100                 105                 110         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        115                 120                 125             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    130                 135                 140                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
145                 150                 155                 160 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                165                 170                 175     


Ala Val Val Asp Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            180                 185                 190         


Ile Leu Ile Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        195                 200                 205             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    210                 215                 220                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
225                 230                 235                 240 


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
                245                 250                 255     


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
            260                 265                 270         


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
        275                 280                 285             


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    290                 295             


<210>  113
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  113

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        35                  40                  45              


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    50                  55                  60                  


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
65                  70                  75                  80  


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                85                  90                  95      


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            100                 105                 110         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        115                 120                 125             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    130                 135                 140                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
145                 150                 155                 160 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                165                 170                 175     


Ala Val Val Arg Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            180                 185                 190         


Ile Leu Ile Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        195                 200                 205             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    210                 215                 220                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
225                 230                 235                 240 


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
                245                 250                 255     


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
            260                 265                 270         


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
        275                 280                 285             


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    290                 295             


<210>  114
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  114

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly 
        35                  40                  45              


Val Val Phe Gly Ile Leu Ile Arg Ser Lys Arg Ser Arg Leu Leu His 
    50                  55                  60                  


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
65                  70                  75                  80  


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  90                  95      


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
            100                 105                 110         


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
        115                 120                 125             


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
    130                 135                 140                 


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
145                 150                 155             


<210>  115
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  115

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Ser Ile Ile Ser Ala Val Glu Gly Ile Leu Leu Val Val Val Leu Gly 
        35                  40                  45              


Val Val Phe Gly Ile Leu Ile Arg Ser Lys Arg Ser Arg Leu Leu His 
    50                  55                  60                  


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
65                  70                  75                  80  


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  90                  95      


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
            100                 105                 110         


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
        115                 120                 125             


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
    130                 135                 140                 


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
145                 150                 155             


<210>  116
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  116

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Ser Ile Ile Ser Ala Val Val Asp Ile Leu Leu Val Val Val Leu Gly 
        35                  40                  45              


Val Val Phe Gly Ile Leu Ile Arg Ser Lys Arg Ser Arg Leu Leu His 
    50                  55                  60                  


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
65                  70                  75                  80  


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  90                  95      


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
            100                 105                 110         


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
        115                 120                 125             


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
    130                 135                 140                 


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
145                 150                 155             


<210>  117
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  117

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Ser Ile Ile Ser Ala Val Val Arg Ile Leu Leu Val Val Val Leu Gly 
        35                  40                  45              


Val Val Phe Gly Ile Leu Ile Arg Ser Lys Arg Ser Arg Leu Leu His 
    50                  55                  60                  


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
65                  70                  75                  80  


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  90                  95      


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
            100                 105                 110         


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
        115                 120                 125             


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
    130                 135                 140                 


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
145                 150                 155             


<210>  118
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  118

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
        35                  40                  45              


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Gly Ser Asp Phe 
    50                  55                  60                  


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
65                  70                  75                  80  


Tyr Ile Asp Pro Arg Ser Asp Ile Pro Tyr Tyr Ala Ser Trp Ala Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 
            100                 105                 110         


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
        115                 120                 125             


Leu Asn Ala Gly Tyr Phe Asn Gly Ile Phe Tyr Ile Trp Gly Pro Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Ser Ser 
                165                 170                 175     


Val Ser Ala Ala Val Gly Asp Thr Val Thr Ile Asn Cys Gln Ala Ser 
            180                 185                 190         


Glu Thr Val Ala Thr Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        195                 200                 205             


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val 
    210                 215                 220                 


Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
225                 230                 235                 240 


Ile Ser Gly Met Lys Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Tyr 
                245                 250                 255     


Gly Tyr Ile Ser Thr Gly Ser Asn Thr Phe Gly Ala Gly Thr Asn Val 
            260                 265                 270         


Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys 
        275                 280                 285             


Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys 
    290                 295                 300                 


Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His 
305                 310                 315                 320 


Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr 
                325                 330                 335     


Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly 
            340                 345                 350         


Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val 
        355                 360                 365             


Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro 
    370                 375                 380                 


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
385                 390                 395                 400 


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
                405                 410                 415     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            420                 425                 430         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        435                 440                 445             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    450                 455                 460                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
465                 470                 475                 480 


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
                485                 490                 495     


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
            500                 505                 510         


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
        515                 520                 525             


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
    530                 535                 540                 


Arg Gln 
545     


<210>  119
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  119

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly Asp 
        35                  40                  45              


Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Thr Val Ala Thr Leu Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Arg Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Met Lys Ala Glu 
            100                 105                 110         


Asp Ala Ala Thr Tyr Tyr Cys Gln Tyr Gly Tyr Ile Ser Thr Gly Ser 
        115                 120                 125             


Asn Thr Phe Gly Ala Gly Thr Asn Val Glu Ile Lys Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Glu Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro Leu Thr Leu Thr 
                165                 170                 175     


Cys Thr Ala Ser Gly Phe Ser Leu Gly Ser Asp Phe Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asp Pro 
        195                 200                 205             


Arg Ser Asp Ile Pro Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr Ser Pro Thr 
225                 230                 235                 240 


Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu Asn Ala Gly 
                245                 250                 255     


Tyr Phe Asn Gly Ile Phe Tyr Ile Trp Gly Pro Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys 
        275                 280                 285             


Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys 
    290                 295                 300                 


Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His 
305                 310                 315                 320 


Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr 
                325                 330                 335     


Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly 
            340                 345                 350         


Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val 
        355                 360                 365             


Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro 
    370                 375                 380                 


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
385                 390                 395                 400 


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
                405                 410                 415     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            420                 425                 430         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        435                 440                 445             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    450                 455                 460                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
465                 470                 475                 480 


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
                485                 490                 495     


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
            500                 505                 510         


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
        515                 520                 525             


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
    530                 535                 540                 


Arg Gln 
545     


<210>  120
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  120

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
        35                  40                  45              


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Gly Ser Asp Phe 
    50                  55                  60                  


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
65                  70                  75                  80  


Tyr Ile Asp Pro Arg Ser Asp Ile Pro Tyr Tyr Ala Ser Trp Ala Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 
            100                 105                 110         


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp 
        115                 120                 125             


Leu Asn Ala Gly Tyr Phe Asn Gly Ile Phe Tyr Ile Trp Gly Pro Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Glu Leu Asp Met Thr Gln Thr Pro Ser Ser 
                165                 170                 175     


Thr Ser Glu Pro Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
            180                 185                 190         


Gln Thr Ile Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly His 
        195                 200                 205             


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Gln Phe Thr Leu Thr 
225                 230                 235                 240 


Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly 
                245                 250                 255     


Val Tyr Asp Tyr Arg Ser Asp Asp Gly Ala Ala Phe Gly Gly Gly Thr 
            260                 265                 270         


Glu Leu Glu Ile Leu Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu 
        275                 280                 285             


Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu 
    290                 295                 300                 


Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser 
305                 310                 315                 320 


Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly 
                325                 330                 335     


Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys 
            340                 345                 350         


Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu 
        355                 360                 365             


Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr 
    370                 375                 380                 


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
385                 390                 395                 400 


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
                405                 410                 415     


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
            420                 425                 430         


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
        435                 440                 445             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    450                 455                 460                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
465                 470                 475                 480 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                485                 490                 495     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            500                 505                 510         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        515                 520                 525             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    530                 535                 540                 


Gln Glu Arg Gln 
545             


<210>  121
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  121

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Leu Asp Met Thr Gln Thr Pro Ser Ser Thr Ser Glu Pro Val Gly Gly 
        35                  40                  45              


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Thr Ile Ser Ser Tyr Leu 
    50                  55                  60                  


Ser Trp Tyr Gln Gln Lys Pro Gly His Pro Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Arg Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Cys Asp 
            100                 105                 110         


Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Asp Tyr Arg Ser Asp 
        115                 120                 125             


Asp Gly Ala Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Glu Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro Leu Thr 
                165                 170                 175     


Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Gly Ser Asp Phe Met Ser 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile 
        195                 200                 205             


Asp Pro Arg Ser Asp Ile Pro Tyr Tyr Ala Ser Trp Ala Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr Ser 
225                 230                 235                 240 


Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Leu Asn 
                245                 250                 255     


Ala Gly Tyr Phe Asn Gly Ile Phe Tyr Ile Trp Gly Pro Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu 
        275                 280                 285             


Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu 
    290                 295                 300                 


Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser 
305                 310                 315                 320 


Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly 
                325                 330                 335     


Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys 
            340                 345                 350         


Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu 
        355                 360                 365             


Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr 
    370                 375                 380                 


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
385                 390                 395                 400 


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
                405                 410                 415     


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
            420                 425                 430         


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
        435                 440                 445             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    450                 455                 460                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
465                 470                 475                 480 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                485                 490                 495     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            500                 505                 510         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        515                 520                 525             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    530                 535                 540                 


Gln Glu Arg Gln 
545             


<210>  122
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  122

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gln 
            20                  25                  30          


Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro Leu 
        35                  40                  45              


Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Asn Asp Met 
    50                  55                  60                  


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Val 
65                  70                  75                  80  


Ile Tyr Ser Asp Asp Thr Pro Asp Tyr Ala Thr Trp Ala Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Ile Thr Ser 
            100                 105                 110         


Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly His Tyr 
        115                 120                 125             


Asp Ser Ala Val Tyr Ala Tyr Ala Leu Asn Ile Trp Gly Pro Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Ser Ser Val 
                165                 170                 175     


Ser Ala Ala Val Gly Gly Thr Val Thr Ile Thr Cys Gln Ala Ser Gln 
            180                 185                 190         


Ser Leu Ser Asn Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        195                 200                 205             


Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro 
    210                 215                 220                 


Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
225                 230                 235                 240 


Ser Gly Met Lys Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly 
                245                 250                 255     


His Tyr Ser Gly Leu Thr Phe Gly Asn Gly Thr Asn Val Glu Ile Lys 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  123
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  123

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
            20                  25                  30          


Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly Gly 
        35                  40                  45              


Thr Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Leu Ser Asn Leu Leu 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Arg Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Met Lys Ala Glu 
            100                 105                 110         


Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly His Tyr Ser Gly Leu Thr 
        115                 120                 125             


Phe Gly Asn Gly Thr Asn Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Leu Glu Glu Ser Gly 
145                 150                 155                 160 


Gly Arg Leu Val Thr Pro Gly Thr Pro Leu Thr Leu Thr Cys Thr Val 
                165                 170                 175     


Ser Gly Phe Ser Leu Ser Thr Asn Asp Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Tyr Ser Asp Asp Thr 
        195                 200                 205             


Pro Asp Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Thr 
    210                 215                 220                 


Ser Thr Thr Val Asp Leu Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Ala Arg Gly His Tyr Asp Ser Ala Val Tyr Ala 
                245                 250                 255     


Tyr Ala Leu Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro 
        275                 280                 285             


Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser 
    290                 295                 300                 


Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu 
305                 310                 315                 320 


Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln 
                325                 330                 335     


Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly 
            340                 345                 350         


Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr 
        355                 360                 365             


Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
    370                 375                 380                 


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
385                 390                 395                 400 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
                405                 410                 415     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            420                 425                 430         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        435                 440                 445             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    450                 455                 460                 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
465                 470                 475                 480 


Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
                485                 490                 495     


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            500                 505                 510         


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        515                 520                 525             


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    530                 535                 540             


<210>  124
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  124

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Ser Thr 
            20                  25                  30          


Thr Gly Val Ala Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser 
        35                  40                  45              


Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala 
    50                  55                  60                  


Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val 
65                  70                  75                  80  


Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His 
                85                  90                  95      


Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly 
            100                 105                 110         


Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Arg Ser Lys Arg Ser 
        115                 120                 125             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    130                 135                 140                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
145                 150                 155                 160 


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
                165                 170                 175     


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
            180                 185                 190         


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
        195                 200                 205             


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
    210                 215                 220                 


Arg Gln 
225     


<210>  125
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  125

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ile Thr Leu 
            20                  25                  30          


Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile 
        35                  40                  45              


Ser Tyr Gly Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    50                  55                  60                  


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
65                  70                  75                  80  


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
                85                  90                  95      


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
            100                 105                 110         


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
        115                 120                 125             


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
    130                 135                 140                 


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
145                 150                 


<210>  126
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  126

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gln Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Glu Gln Lys Leu Ile Ser Glu Glu 
            20                  25                  30          


Asp Leu Ala Pro Pro Pro Asn Leu Pro Asp Pro Lys Phe Glu Ser Lys 
        35                  40                  45              


Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu Glu Leu Leu Cys Phe Thr 
    50                  55                  60                  


Glu Arg Leu Glu Asp Leu Val Cys Phe Trp Glu Glu Ala Ala Ser Ala 
65                  70                  75                  80  


Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser Tyr Gln Leu Glu Asp Glu 
                85                  90                  95      


Pro Trp Lys Leu Cys Arg Leu His Gln Ala Pro Thr Ala Arg Gly Ala 
            100                 105                 110         


Val Arg Phe Trp Cys Ser Leu Pro Thr Ala Asp Thr Ser Ser Phe Val 
        115                 120                 125             


Pro Leu Glu Leu Arg Val Thr Ala Ala Ser Gly Ala Pro Arg Tyr His 
    130                 135                 140                 


Arg Val Ile His Ile Asn Glu Val Val Leu Leu Asp Ala Pro Val Gly 
145                 150                 155                 160 


Leu Val Ala Arg Leu Ala Asp Glu Ser Gly His Val Val Leu Arg Trp 
                165                 170                 175     


Leu Pro Pro Pro Glu Thr Pro Met Thr Ser His Ile Arg Tyr Glu Val 
            180                 185                 190         


Asp Val Ser Ala Gly Asn Gly Ala Gly Ser Val Gln Arg Val Glu Ile 
        195                 200                 205             


Leu Glu Gly Arg Thr Glu Cys Val Leu Ser Asn Leu Arg Gly Arg Thr 
    210                 215                 220                 


Arg Tyr Thr Phe Ala Val Arg Ala Arg Met Ala Glu Pro Ser Phe Gly 
225                 230                 235                 240 


Gly Phe Trp Ser Ala Trp Ser Glu Pro Val Ser Leu Leu Thr Pro Ser 
                245                 250                 255     


Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser Leu Ile Leu Val Val Ile 
            260                 265                 270         


Leu Val Leu Leu Thr Val Leu Ala Leu Leu Ser Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
                325                 330                 335     


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
            340                 345                 350         


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
        355                 360                 365             


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
    370                 375                 380                 


Arg Gln 
385     


<210>  127
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  127

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gln Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Glu Gln Lys Leu Ile Ser Glu Glu 
            20                  25                  30          


Asp Leu Leu Ile Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val 
        35                  40                  45              


Leu Leu Thr Val Leu Ala Leu Leu Ser Arg Ser Lys Arg Ser Arg Leu 
    50                  55                  60                  


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
65                  70                  75                  80  


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                85                  90                  95      


Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro 
            100                 105                 110         


Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser 
        115                 120                 125             


Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val 
    130                 135                 140                 


Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
145                 150                 155                 160 


<210>  128
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  128

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Gln Asp Val Ser Leu Leu Ala Ser Asp Ser Glu Pro Leu 
        35                  40                  45              


Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu Thr Cys Phe Trp Asp Glu 
    50                  55                  60                  


Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln Leu Leu Tyr Ala Tyr Pro 
65                  70                  75                  80  


Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser Ser Gln Ser Met Pro His 
                85                  90                  95      


Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro Asp Gln Glu Glu Val Arg 
            100                 105                 110         


Leu Phe Phe Pro Leu His Leu Trp Val Lys Asn Val Phe Leu Asn Gln 
        115                 120                 125             


Thr Arg Thr Gln Arg Val Leu Phe Val Asp Ser Val Gly Leu Pro Ala 
    130                 135                 140                 


Pro Pro Ser Ile Ile Lys Ala Met Gly Gly Ser Gln Pro Gly Glu Leu 
145                 150                 155                 160 


Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu Ile Ser Asp Phe Leu Arg 
                165                 170                 175     


Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro Lys Asn Ser Thr Gly Pro 
            180                 185                 190         


Thr Val Ile Gln Leu Ile Ala Thr Glu Thr Cys Cys Pro Ala Leu Gln 
        195                 200                 205             


Arg Pro His Ser Ala Ser Ala Leu Asp Gln Ser Pro Cys Ala Gln Pro 
    210                 215                 220                 


Thr Met Pro Trp Gln Asp Gly Pro Lys Gln Thr Ser Pro Ser Arg Glu 
225                 230                 235                 240 


Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser Cys Leu Ile Ser Gly Leu 
                245                 250                 255     


Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu Arg Ser Glu Pro Asp Gly 
            260                 265                 270         


Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp Ser Leu Pro Val Thr Val 
        275                 280                 285             


Asp Leu Pro Gly Asp Ala Val Ala Leu Gly Leu Gln Cys Phe Thr Leu 
    290                 295                 300                 


Asp Leu Lys Asn Val Thr Cys Gln Trp Gln Gln Gln Asp His Ala Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Phe Tyr His Ser Arg Ala Arg Cys Cys Pro Arg Asp 
                325                 330                 335     


Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu Glu Glu Lys Thr Asn Pro 
            340                 345                 350         


Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys His Phe Lys Ser Arg Asn 
        355                 360                 365             


Asp Ser Ile Ile His Ile Leu Val Glu Val Thr Thr Ala Pro Gly Thr 
    370                 375                 380                 


Val His Ser Tyr Leu Gly Ser Pro Phe Trp Ile His Gln Ala Val Arg 
385                 390                 395                 400 


Leu Pro Thr Pro Asn Leu His Trp Arg Glu Ile Ser Ser Gly His Leu 
                405                 410                 415     


Glu Leu Glu Trp Gln His Pro Ser Ser Trp Ala Ala Gln Glu Thr Cys 
            420                 425                 430         


Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His Gln Asp Trp Lys Val Leu 
        435                 440                 445             


Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr Leu Glu Leu Arg Pro Arg 
    450                 455                 460                 


Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg Leu Asn Gly Pro Thr Tyr 
465                 470                 475                 480 


Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro Thr Arg Val Glu Thr Ala 
                485                 490                 495     


Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu His Leu Val Leu 
            500                 505                 510         


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys 
        515                 520                 525             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    530                 535                 540                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
545                 550                 555                 560 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                565                 570                 575     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            580                 585                 590         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        595                 600                 605             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    610                 615                 620                 


Gln Glu Arg Gln 
625             


<210>  129
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  129

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu 
        35                  40                  45              


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys Arg Ser 
    50                  55                  60                  


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
65                  70                  75                  80  


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
                85                  90                  95      


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
            100                 105                 110         


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
        115                 120                 125             


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
    130                 135                 140                 


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
145                 150                 155                 160 


Arg Gln 
        


<210>  130
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  130

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Gln Asp Val Ser Leu Leu Ala Ser Asp Ser Glu Pro Leu 
        35                  40                  45              


Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu Thr Cys Phe Trp Asp Glu 
    50                  55                  60                  


Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln Leu Leu Tyr Ala Tyr Pro 
65                  70                  75                  80  


Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser Ser Gln Ser Met Pro His 
                85                  90                  95      


Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro Asp Gln Glu Glu Val Arg 
            100                 105                 110         


Leu Phe Phe Pro Leu His Leu Trp Val Lys Asn Val Phe Leu Asn Gln 
        115                 120                 125             


Thr Arg Thr Gln Arg Val Leu Phe Val Asp Ser Val Gly Leu Pro Ala 
    130                 135                 140                 


Pro Pro Ser Ile Ile Lys Ala Met Gly Gly Ser Gln Pro Gly Glu Leu 
145                 150                 155                 160 


Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu Ile Ser Asp Phe Leu Arg 
                165                 170                 175     


Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro Lys Asn Ser Thr Gly Pro 
            180                 185                 190         


Thr Val Ile Gln Leu Ile Ala Thr Glu Thr Cys Cys Pro Ala Leu Gln 
        195                 200                 205             


Arg Pro His Ser Ala Ser Ala Leu Asp Gln Ser Pro Cys Ala Gln Pro 
    210                 215                 220                 


Thr Met Pro Trp Gln Asp Gly Pro Lys Gln Thr Ser Pro Ser Arg Glu 
225                 230                 235                 240 


Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser Cys Leu Ile Ser Gly Leu 
                245                 250                 255     


Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu Arg Ser Glu Pro Asp Gly 
            260                 265                 270         


Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp Ser Leu Pro Val Thr Val 
        275                 280                 285             


Asp Leu Pro Gly Asp Ala Val Ala Leu Gly Leu Gln Cys Phe Thr Leu 
    290                 295                 300                 


Asp Leu Lys Asn Val Thr Cys Gln Trp Gln Gln Gln Asp His Ala Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Phe Tyr His Ser Arg Ala Arg Cys Cys Pro Arg Asp 
                325                 330                 335     


Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu Glu Glu Lys Thr Asn Pro 
            340                 345                 350         


Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys His Phe Lys Ser Arg Asn 
        355                 360                 365             


Asp Ser Ile Ile His Ile Leu Val Glu Val Thr Thr Ala Pro Gly Thr 
    370                 375                 380                 


Val His Ser Tyr Leu Gly Ser Pro Phe Trp Ile His Gln Ala Val Arg 
385                 390                 395                 400 


Leu Pro Thr Pro Asn Leu His Trp Arg Glu Ile Ser Ser Gly His Leu 
                405                 410                 415     


Glu Leu Glu Trp Gln His Pro Ser Ser Trp Ala Ala Gln Glu Thr Cys 
            420                 425                 430         


Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His Gln Asp Trp Lys Val Leu 
        435                 440                 445             


Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr Leu Glu Leu Arg Pro Arg 
    450                 455                 460                 


Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg Leu Asn Gly Pro Thr Tyr 
465                 470                 475                 480 


Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro Thr Arg Val Glu Thr Ala 
                485                 490                 495     


Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu His Leu Val Leu 
            500                 505                 510         


Gly Leu Asn Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys 
        515                 520                 525             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    530                 535                 540                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
545                 550                 555                 560 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                565                 570                 575     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            580                 585                 590         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        595                 600                 605             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    610                 615                 620                 


Gln Glu Arg Gln 
625             


<210>  131
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  131

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu 
        35                  40                  45              


Asn Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys Arg Ser 
    50                  55                  60                  


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
65                  70                  75                  80  


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
                85                  90                  95      


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
            100                 105                 110         


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
        115                 120                 125             


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
    130                 135                 140                 


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
145                 150                 155                 160 


Arg Gln 
        


<210>  132
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  132

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Gln Asp Val Ser Leu Leu Ala Ser Asp Ser Glu Pro Leu 
        35                  40                  45              


Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu Thr Cys Phe Trp Asp Glu 
    50                  55                  60                  


Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln Leu Leu Tyr Ala Tyr Pro 
65                  70                  75                  80  


Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser Ser Gln Ser Met Pro His 
                85                  90                  95      


Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro Asp Gln Glu Glu Val Arg 
            100                 105                 110         


Leu Phe Phe Pro Leu His Leu Trp Val Lys Asn Val Phe Leu Asn Gln 
        115                 120                 125             


Thr Arg Thr Gln Arg Val Leu Phe Val Asp Ser Val Gly Leu Pro Ala 
    130                 135                 140                 


Pro Pro Ser Ile Ile Lys Ala Met Gly Gly Ser Gln Pro Gly Glu Leu 
145                 150                 155                 160 


Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu Ile Ser Asp Phe Leu Arg 
                165                 170                 175     


Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro Lys Asn Ser Thr Gly Pro 
            180                 185                 190         


Thr Val Ile Gln Leu Ile Ala Thr Glu Thr Cys Cys Pro Ala Leu Gln 
        195                 200                 205             


Arg Pro His Ser Ala Ser Ala Leu Asp Gln Ser Pro Cys Ala Gln Pro 
    210                 215                 220                 


Thr Met Pro Trp Gln Asp Gly Pro Lys Gln Thr Ser Pro Ser Arg Glu 
225                 230                 235                 240 


Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser Cys Leu Ile Ser Gly Leu 
                245                 250                 255     


Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu Arg Ser Glu Pro Asp Gly 
            260                 265                 270         


Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp Ser Leu Pro Val Thr Val 
        275                 280                 285             


Asp Leu Pro Gly Asp Ala Val Ala Leu Gly Leu Gln Cys Phe Thr Leu 
    290                 295                 300                 


Asp Leu Lys Asn Val Thr Cys Gln Trp Gln Gln Gln Asp His Ala Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Phe Tyr His Ser Arg Ala Arg Cys Cys Pro Arg Asp 
                325                 330                 335     


Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu Glu Glu Lys Thr Asn Pro 
            340                 345                 350         


Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys His Phe Lys Ser Arg Asn 
        355                 360                 365             


Asp Ser Ile Ile His Ile Leu Val Glu Val Thr Thr Ala Pro Gly Thr 
    370                 375                 380                 


Val His Ser Tyr Leu Gly Ser Pro Phe Trp Ile His Gln Ala Val Arg 
385                 390                 395                 400 


Leu Pro Thr Pro Asn Leu His Trp Arg Glu Ile Ser Ser Gly His Leu 
                405                 410                 415     


Glu Leu Glu Trp Gln His Pro Ser Ser Trp Ala Ala Gln Glu Thr Cys 
            420                 425                 430         


Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His Gln Asp Trp Lys Val Leu 
        435                 440                 445             


Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr Leu Glu Leu Arg Pro Arg 
    450                 455                 460                 


Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg Leu Asn Gly Pro Thr Tyr 
465                 470                 475                 480 


Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro Thr Arg Val Glu Thr Ala 
                485                 490                 495     


Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu His Leu Val Leu 
            500                 505                 510         


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Lys Arg Ser Lys 
        515                 520                 525             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    530                 535                 540                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
545                 550                 555                 560 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                565                 570                 575     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            580                 585                 590         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        595                 600                 605             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    610                 615                 620                 


Gln Glu Arg Gln 
625             


<210>  133
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  133

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu 
        35                  40                  45              


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Lys Arg Ser Lys Arg Ser 
    50                  55                  60                  


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
65                  70                  75                  80  


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
                85                  90                  95      


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
            100                 105                 110         


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
        115                 120                 125             


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
    130                 135                 140                 


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
145                 150                 155                 160 


Arg Gln 
        


<210>  134
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  134

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Gln Asp Val Ser Leu Leu Ala Ser Asp Ser Glu Pro Leu 
        35                  40                  45              


Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu Thr Cys Phe Trp Asp Glu 
    50                  55                  60                  


Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln Leu Leu Tyr Ala Tyr Pro 
65                  70                  75                  80  


Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser Ser Gln Ser Met Pro His 
                85                  90                  95      


Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro Asp Gln Glu Glu Val Arg 
            100                 105                 110         


Leu Phe Phe Pro Leu His Leu Trp Val Lys Asn Val Phe Leu Asn Gln 
        115                 120                 125             


Thr Arg Thr Gln Arg Val Leu Phe Val Asp Ser Val Gly Leu Pro Ala 
    130                 135                 140                 


Pro Pro Ser Ile Ile Lys Ala Met Gly Gly Ser Gln Pro Gly Glu Leu 
145                 150                 155                 160 


Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu Ile Ser Asp Phe Leu Arg 
                165                 170                 175     


Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro Lys Asn Ser Thr Gly Pro 
            180                 185                 190         


Thr Val Ile Gln Leu Ile Ala Thr Glu Thr Cys Cys Pro Ala Leu Gln 
        195                 200                 205             


Arg Pro His Ser Ala Ser Ala Leu Asp Gln Ser Pro Cys Ala Gln Pro 
    210                 215                 220                 


Thr Met Pro Trp Gln Asp Gly Pro Lys Gln Thr Ser Pro Ser Arg Glu 
225                 230                 235                 240 


Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser Cys Leu Ile Ser Gly Leu 
                245                 250                 255     


Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu Arg Ser Glu Pro Asp Gly 
            260                 265                 270         


Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp Ser Leu Pro Val Thr Val 
        275                 280                 285             


Asp Leu Pro Gly Asp Ala Val Ala Leu Gly Leu Gln Cys Phe Thr Leu 
    290                 295                 300                 


Asp Leu Lys Asn Val Thr Cys Gln Trp Gln Gln Gln Asp His Ala Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Phe Tyr His Ser Arg Ala Arg Cys Cys Pro Arg Asp 
                325                 330                 335     


Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu Glu Glu Lys Thr Asn Pro 
            340                 345                 350         


Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys His Phe Lys Ser Arg Asn 
        355                 360                 365             


Asp Ser Ile Ile His Ile Leu Val Glu Val Thr Thr Ala Pro Gly Thr 
    370                 375                 380                 


Val His Ser Tyr Leu Gly Ser Pro Phe Trp Ile His Gln Ala Val Arg 
385                 390                 395                 400 


Leu Pro Thr Pro Asn Leu His Trp Arg Glu Ile Ser Ser Gly His Leu 
                405                 410                 415     


Glu Leu Glu Trp Gln His Pro Ser Ser Trp Ala Ala Gln Glu Thr Cys 
            420                 425                 430         


Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His Gln Asp Trp Lys Val Leu 
        435                 440                 445             


Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr Leu Glu Leu Arg Pro Arg 
    450                 455                 460                 


Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg Leu Asn Gly Pro Thr Tyr 
465                 470                 475                 480 


Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro Thr Arg Val Glu Thr Ala 
                485                 490                 495     


Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu Leu Leu Val Leu 
            500                 505                 510         


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys 
        515                 520                 525             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    530                 535                 540                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
545                 550                 555                 560 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                565                 570                 575     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            580                 585                 590         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        595                 600                 605             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    610                 615                 620                 


Gln Glu Arg Gln 
625             


<210>  135
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  135

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Ile Ser Leu Val Thr Ala Leu Leu Leu Val Leu Gly Leu 
        35                  40                  45              


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys Arg Ser 
    50                  55                  60                  


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
65                  70                  75                  80  


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
                85                  90                  95      


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
            100                 105                 110         


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
        115                 120                 125             


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
    130                 135                 140                 


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
145                 150                 155                 160 


Arg Gln 
        


<210>  136
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  136

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Gln Asp Val Ser Leu Leu Ala Ser Asp Ser Glu Pro Leu 
        35                  40                  45              


Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu Thr Cys Phe Trp Asp Glu 
    50                  55                  60                  


Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln Leu Leu Tyr Ala Tyr Pro 
65                  70                  75                  80  


Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser Ser Gln Ser Met Pro His 
                85                  90                  95      


Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro Asp Gln Glu Glu Val Arg 
            100                 105                 110         


Leu Phe Phe Pro Leu His Leu Trp Val Lys Asn Val Phe Leu Asn Gln 
        115                 120                 125             


Thr Arg Thr Gln Arg Val Leu Phe Val Asp Ser Val Gly Leu Pro Ala 
    130                 135                 140                 


Pro Pro Ser Ile Ile Lys Ala Met Gly Gly Ser Gln Pro Gly Glu Leu 
145                 150                 155                 160 


Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu Ile Ser Asp Phe Leu Arg 
                165                 170                 175     


Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro Lys Asn Ser Thr Gly Pro 
            180                 185                 190         


Thr Val Ile Gln Leu Ile Ala Thr Glu Thr Cys Cys Pro Ala Leu Gln 
        195                 200                 205             


Arg Pro His Ser Ala Ser Ala Leu Asp Gln Ser Pro Cys Ala Gln Pro 
    210                 215                 220                 


Thr Met Pro Trp Gln Asp Gly Pro Lys Gln Thr Ser Pro Ser Arg Glu 
225                 230                 235                 240 


Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser Cys Leu Ile Ser Gly Leu 
                245                 250                 255     


Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu Arg Ser Glu Pro Asp Gly 
            260                 265                 270         


Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp Ser Leu Pro Val Thr Val 
        275                 280                 285             


Asp Leu Pro Gly Asp Ala Val Ala Leu Gly Leu Gln Cys Phe Thr Leu 
    290                 295                 300                 


Asp Leu Lys Asn Val Thr Cys Gln Trp Gln Gln Gln Asp His Ala Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Phe Tyr His Ser Arg Ala Arg Cys Cys Pro Arg Asp 
                325                 330                 335     


Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu Glu Glu Lys Thr Asn Pro 
            340                 345                 350         


Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys His Phe Lys Ser Arg Asn 
        355                 360                 365             


Asp Ser Ile Ile His Ile Leu Val Glu Val Thr Thr Ala Pro Gly Thr 
    370                 375                 380                 


Val His Ser Tyr Leu Gly Ser Pro Phe Trp Ile His Gln Ala Val Arg 
385                 390                 395                 400 


Leu Pro Thr Pro Asn Leu His Trp Arg Glu Ile Ser Ser Gly His Leu 
                405                 410                 415     


Glu Leu Glu Trp Gln His Pro Ser Ser Trp Ala Ala Gln Glu Thr Cys 
            420                 425                 430         


Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His Gln Asp Trp Lys Val Leu 
        435                 440                 445             


Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr Leu Glu Leu Arg Pro Arg 
    450                 455                 460                 


Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg Leu Asn Gly Pro Thr Tyr 
465                 470                 475                 480 


Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro Thr Arg Val Glu Thr Ala 
                485                 490                 495     


Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu His Leu Val Leu 
            500                 505                 510         


Gly Leu Asn Ala Val Leu Gly Leu Leu Leu Leu Arg Lys Arg Ser Lys 
        515                 520                 525             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    530                 535                 540                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
545                 550                 555                 560 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                565                 570                 575     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            580                 585                 590         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        595                 600                 605             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    610                 615                 620                 


Gln Glu Arg Gln 
625             


<210>  137
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  137

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu 
        35                  40                  45              


Asn Ala Val Leu Gly Leu Leu Leu Leu Arg Lys Arg Ser Lys Arg Ser 
    50                  55                  60                  


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
65                  70                  75                  80  


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
                85                  90                  95      


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
            100                 105                 110         


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
        115                 120                 125             


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
    130                 135                 140                 


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
145                 150                 155                 160 


Arg Gln 
        


<210>  138
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  138

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Gln Asp Val Ser Leu Leu Ala Ser Asp Ser Glu Pro Leu 
        35                  40                  45              


Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu Thr Cys Phe Trp Asp Glu 
    50                  55                  60                  


Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln Leu Leu Tyr Ala Tyr Pro 
65                  70                  75                  80  


Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser Ser Gln Ser Met Pro His 
                85                  90                  95      


Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro Asp Gln Glu Glu Val Arg 
            100                 105                 110         


Leu Phe Phe Pro Leu His Leu Trp Val Lys Asn Val Phe Leu Asn Gln 
        115                 120                 125             


Thr Arg Thr Gln Arg Val Leu Phe Val Asp Ser Val Gly Leu Pro Ala 
    130                 135                 140                 


Pro Pro Ser Ile Ile Lys Ala Met Gly Gly Ser Gln Pro Gly Glu Leu 
145                 150                 155                 160 


Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu Ile Ser Asp Phe Leu Arg 
                165                 170                 175     


Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro Lys Asn Ser Thr Gly Pro 
            180                 185                 190         


Thr Val Ile Gln Leu Ile Ala Thr Glu Thr Cys Cys Pro Ala Leu Gln 
        195                 200                 205             


Arg Pro His Ser Ala Ser Ala Leu Asp Gln Ser Pro Cys Ala Gln Pro 
    210                 215                 220                 


Thr Met Pro Trp Gln Asp Gly Pro Lys Gln Thr Ser Pro Ser Arg Glu 
225                 230                 235                 240 


Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser Cys Leu Ile Ser Gly Leu 
                245                 250                 255     


Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu Arg Ser Glu Pro Asp Gly 
            260                 265                 270         


Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp Ser Leu Pro Val Thr Val 
        275                 280                 285             


Asp Leu Pro Gly Asp Ala Val Ala Leu Gly Leu Gln Cys Phe Thr Leu 
    290                 295                 300                 


Asp Leu Lys Asn Val Thr Cys Gln Trp Gln Gln Gln Asp His Ala Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Phe Tyr His Ser Arg Ala Arg Cys Cys Pro Arg Asp 
                325                 330                 335     


Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu Glu Glu Lys Thr Asn Pro 
            340                 345                 350         


Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys His Phe Lys Ser Arg Asn 
        355                 360                 365             


Asp Ser Ile Ile His Ile Leu Val Glu Val Thr Thr Ala Pro Gly Thr 
    370                 375                 380                 


Val His Ser Tyr Leu Gly Ser Pro Phe Trp Ile His Gln Ala Val Arg 
385                 390                 395                 400 


Leu Pro Thr Pro Asn Leu His Trp Arg Glu Ile Ser Ser Gly His Leu 
                405                 410                 415     


Glu Leu Glu Trp Gln His Pro Ser Ser Trp Ala Ala Gln Glu Thr Cys 
            420                 425                 430         


Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His Gln Asp Trp Lys Val Leu 
        435                 440                 445             


Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr Leu Glu Leu Arg Pro Arg 
    450                 455                 460                 


Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg Leu Asn Gly Pro Thr Tyr 
465                 470                 475                 480 


Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro Thr Arg Val Glu Thr Ala 
                485                 490                 495     


Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu Tyr Leu Val Leu 
            500                 505                 510         


Gly Leu Asn Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys 
        515                 520                 525             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    530                 535                 540                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
545                 550                 555                 560 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                565                 570                 575     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            580                 585                 590         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        595                 600                 605             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    610                 615                 620                 


Gln Glu Arg Gln 
625             


<210>  139
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  139

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Ile Ser Leu Val Thr Ala Leu Tyr Leu Val Leu Gly Leu 
        35                  40                  45              


Asn Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys Arg Ser 
    50                  55                  60                  


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
65                  70                  75                  80  


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
                85                  90                  95      


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
            100                 105                 110         


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
        115                 120                 125             


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
    130                 135                 140                 


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
145                 150                 155                 160 


Arg Gln 
        


<210>  140
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  140

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Gln Asp Val Ser Leu Leu Ala Ser Asp Ser Glu Pro Leu 
        35                  40                  45              


Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu Thr Cys Phe Trp Asp Glu 
    50                  55                  60                  


Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln Leu Leu Tyr Ala Tyr Pro 
65                  70                  75                  80  


Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser Ser Gln Ser Met Pro His 
                85                  90                  95      


Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro Asp Gln Glu Glu Val Arg 
            100                 105                 110         


Leu Phe Phe Pro Leu His Leu Trp Val Lys Asn Val Phe Leu Asn Gln 
        115                 120                 125             


Thr Arg Thr Gln Arg Val Leu Phe Val Asp Ser Val Gly Leu Pro Ala 
    130                 135                 140                 


Pro Pro Ser Ile Ile Lys Ala Met Gly Gly Ser Gln Pro Gly Glu Leu 
145                 150                 155                 160 


Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu Ile Ser Asp Phe Leu Arg 
                165                 170                 175     


Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro Lys Asn Ser Thr Gly Pro 
            180                 185                 190         


Thr Val Ile Gln Leu Ile Ala Thr Glu Thr Cys Cys Pro Ala Leu Gln 
        195                 200                 205             


Arg Pro His Ser Ala Ser Ala Leu Asp Gln Ser Pro Cys Ala Gln Pro 
    210                 215                 220                 


Thr Met Pro Trp Gln Asp Gly Pro Lys Gln Thr Ser Pro Ser Arg Glu 
225                 230                 235                 240 


Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser Cys Leu Ile Ser Gly Leu 
                245                 250                 255     


Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu Arg Ser Glu Pro Asp Gly 
            260                 265                 270         


Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp Ser Leu Pro Val Thr Val 
        275                 280                 285             


Asp Leu Pro Gly Asp Ala Val Ala Leu Gly Leu Gln Cys Phe Thr Leu 
    290                 295                 300                 


Asp Leu Lys Asn Val Thr Cys Gln Trp Gln Gln Gln Asp His Ala Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Phe Tyr His Ser Arg Ala Arg Cys Cys Pro Arg Asp 
                325                 330                 335     


Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu Glu Glu Lys Thr Asn Pro 
            340                 345                 350         


Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys His Phe Lys Ser Arg Asn 
        355                 360                 365             


Asp Ser Ile Ile His Ile Leu Val Glu Val Thr Thr Ala Pro Gly Thr 
    370                 375                 380                 


Val His Ser Tyr Leu Gly Ser Pro Phe Trp Ile His Gln Ala Val Arg 
385                 390                 395                 400 


Leu Pro Thr Pro Asn Leu His Trp Arg Glu Ile Ser Ser Gly His Leu 
                405                 410                 415     


Glu Leu Glu Trp Gln His Pro Ser Ser Trp Ala Ala Gln Glu Thr Cys 
            420                 425                 430         


Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His Gln Asp Trp Lys Val Leu 
        435                 440                 445             


Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr Leu Glu Leu Arg Pro Arg 
    450                 455                 460                 


Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg Leu Asn Gly Pro Thr Tyr 
465                 470                 475                 480 


Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro Thr Arg Val Glu Thr Ala 
                485                 490                 495     


Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Trp Cys Leu Val Leu 
            500                 505                 510         


Gly Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys 
        515                 520                 525             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    530                 535                 540                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
545                 550                 555                 560 


Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys 
                565                 570                 575     


Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp 
            580                 585                 590         


Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly 
        595                 600                 605             


Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val 
    610                 615                 620                 


Gln Glu Arg Gln 
625             


<210>  141
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  141

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Glu Gln Lys Leu Ile Ser Glu 
            20                  25                  30          


Glu Asp Leu Ile Ser Leu Val Thr Ala Trp Cys Leu Val Leu Gly Leu 
        35                  40                  45              


Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Arg Ser Lys Arg Ser 
    50                  55                  60                  


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
65                  70                  75                  80  


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
                85                  90                  95      


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
            100                 105                 110         


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
        115                 120                 125             


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
    130                 135                 140                 


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
145                 150                 155                 160 


Arg Gln 
        


<210>  142
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  142

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            20                  25                  30          


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        35                  40                  45              


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    50                  55                  60                  


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
65                  70                  75                  80  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                85                  90                  95      


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            100                 105                 110         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        115                 120                 125             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    130                 135                 140                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
145                 150                 155                 160 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                165                 170                 175     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            180                 185                 190         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        195                 200                 205             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    210                 215                 220                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
225                 230                 235                 240 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
                325                 330                 335     


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
            340                 345                 350         


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
        355                 360                 365             


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
    370                 375                 380                 


Arg Gln 
385     


<210>  143
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  143

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
        35                  40                  45              


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu 
    50                  55                  60                  


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
65                  70                  75                  80  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                85                  90                  95      


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            100                 105                 110         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        115                 120                 125             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    130                 135                 140                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
145                 150                 155                 160 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                165                 170                 175     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            180                 185                 190         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        195                 200                 205             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    210                 215                 220                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
225                 230                 235                 240 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro 
                245                 250                 255     


Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            260                 265                 270         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        275                 280                 285             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    290                 295                 300                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
305                 310                 315                 320 


Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala 
                325                 330                 335     


Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu 
            340                 345                 350         


Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys 
        355                 360                 365             


Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln 
    370                 375                 380                 


Glu Arg Gln 
385         


<210>  144
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  144

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        35                  40                  45              


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    50                  55                  60                  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
65                  70                  75                  80  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                85                  90                  95      


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
            100                 105                 110         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        115                 120                 125             


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
    130                 135                 140                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
145                 150                 155                 160 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                165                 170                 175     


Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            180                 185                 190         


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        195                 200                 205             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    210                 215                 220                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
225                 230                 235                 240 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Phe Trp Val Leu Val Val Val 
                245                 250                 255     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            260                 265                 270         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        275                 280                 285             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    290                 295                 300                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val 
305                 310                 315                 320 


Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln 
                325                 330                 335     


Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro 
            340                 345                 350         


Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly 
        355                 360                 365             


Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    370                 375                 


<210>  145
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  145

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
            20                  25                  30          


Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        35                  40                  45              


Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    50                  55                  60                  


Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
65                  70                  75                  80  


Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                85                  90                  95      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            100                 105                 110         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
        115                 120                 125             


Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    130                 135                 140                 


Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
145                 150                 155                 160 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                165                 170                 175     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            180                 185                 190         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        195                 200                 205             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    210                 215                 220                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro 
225                 230                 235                 240 


Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
                245                 250                 255     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            260                 265                 270         


Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg 
        275                 280                 285             


Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Phe Trp Val Leu 
    290                 295                 300                 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
305                 310                 315                 320 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
                325                 330                 335     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            340                 345                 350         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        355                 360                 365             


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
    370                 375                 380                 


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
385                 390                 395                 400 


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
                405                 410                 415     


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            420                 425                 430 


<210>  146
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  146

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
            20                  25                  30          


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
145                 150                 155                 160 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Trp Val Leu Val Val 
                245                 250                 255     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            260                 265                 270         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        275                 280                 285             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    290                 295                 300                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys 
305                 310                 315                 320 


Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro 
                325                 330                 335     


Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala 
            340                 345                 350         


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
        355                 360                 365             


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    370                 375                 380 


<210>  147
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  147

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
145                 150                 155                 160 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Trp Val Leu Val Val 
                245                 250                 255     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            260                 265                 270         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        275                 280                 285             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    290                 295                 300                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys 
305                 310                 315                 320 


Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro 
                325                 330                 335     


Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala 
            340                 345                 350         


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
        355                 360                 365             


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    370                 375                 380 


<210>  148
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  148

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            20                  25                  30          


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        35                  40                  45              


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    50                  55                  60                  


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
65                  70                  75                  80  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                85                  90                  95      


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            100                 105                 110         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        115                 120                 125             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    130                 135                 140                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
145                 150                 155                 160 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                165                 170                 175     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            180                 185                 190         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        195                 200                 205             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    210                 215                 220                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
225                 230                 235                 240 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala 
                245                 250                 255     


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
            260                 265                 270         


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
        275                 280                 285             


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    290                 295                 300                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
305                 310                 315                 320 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                325                 330                 335     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            340                 345                 350         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys 
        355                 360                 365             


Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile 
    370                 375                 380                 


Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln 
385                 390                 395                 400 


Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu 
                405                 410                 415     


Ser Arg Ile Ser Val Gln Glu Arg Gln 
            420                 425 


<210>  149
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  149

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
        35                  40                  45              


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu 
    50                  55                  60                  


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
65                  70                  75                  80  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                85                  90                  95      


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            100                 105                 110         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        115                 120                 125             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    130                 135                 140                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
145                 150                 155                 160 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                165                 170                 175     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            180                 185                 190         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        195                 200                 205             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    210                 215                 220                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
225                 230                 235                 240 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro 
                245                 250                 255     


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
            260                 265                 270         


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
        275                 280                 285             


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
    290                 295                 300                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
305                 310                 315                 320 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                325                 330                 335     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            340                 345                 350         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala 
        355                 360                 365             


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
    370                 375                 380                 


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
385                 390                 395                 400 


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
                405                 410                 415     


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            420                 425     


<210>  150
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  150

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        35                  40                  45              


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    50                  55                  60                  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
65                  70                  75                  80  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                85                  90                  95      


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
            100                 105                 110         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        115                 120                 125             


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
    130                 135                 140                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
145                 150                 155                 160 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                165                 170                 175     


Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            180                 185                 190         


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        195                 200                 205             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    210                 215                 220                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
225                 230                 235                 240 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Val Met Tyr Pro Pro 
                245                 250                 255     


Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys 
            260                 265                 270         


Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
        355                 360                 365             


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
    370                 375                 380                 


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
385                 390                 395                 400 


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
                405                 410                 415     


Arg Gln 
        


<210>  151
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  151

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
            20                  25                  30          


Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
        35                  40                  45              


Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
    50                  55                  60                  


Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
65                  70                  75                  80  


Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                85                  90                  95      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            100                 105                 110         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
        115                 120                 125             


Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    130                 135                 140                 


Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
145                 150                 155                 160 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                165                 170                 175     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            180                 185                 190         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        195                 200                 205             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    210                 215                 220                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro 
225                 230                 235                 240 


Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
                245                 250                 255     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            260                 265                 270         


Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg 
        275                 280                 285             


Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Val Met 
    290                 295                 300                 


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
305                 310                 315                 320 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
                325                 330                 335     


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            340                 345                 350         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        355                 360                 365             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    370                 375                 380                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
385                 390                 395                 400 


Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn 
                405                 410                 415     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            420                 425                 430         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        435                 440                 445             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    450                 455                 460                 


Val Gln Glu Arg Gln 
465                 


<210>  152
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  152

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
            20                  25                  30          


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
145                 150                 155                 160 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Val Met Tyr Pro 
                245                 250                 255     


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
            260                 265                 270         


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
        275                 280                 285             


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala 
        355                 360                 365             


Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu 
    370                 375                 380                 


Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys 
385                 390                 395                 400 


Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln 
                405                 410                 415     


Glu Arg Gln 
            


<210>  153
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  153

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
145                 150                 155                 160 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Val Met Tyr Pro 
                245                 250                 255     


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
            260                 265                 270         


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
        275                 280                 285             


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
    290                 295                 300                 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
305                 310                 315                 320 


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
                325                 330                 335     


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
            340                 345                 350         


Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala 
        355                 360                 365             


Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu 
    370                 375                 380                 


Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys 
385                 390                 395                 400 


Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln 
                405                 410                 415     


Glu Arg Gln 
            


<210>  154
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(61)
<223>  CD40

<400>  154

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  155
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(124)
<223>  CD40_tandem

<400>  155

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Lys Lys 
    50                  55                  60                  


Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro 
65                  70                  75                  80  


Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala 
                85                  90                  95      


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
            100                 105                 110         


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
        115                 120                 


<210>  156
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(62)
<223>  CD40_P227A

<400>  156

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Ala His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  157

Ala Ala Ala Gly Ser Gly Gly Ser Gly 
1               5                   


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  158

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


