                               SEQUENCE LISTING

<110> SALK INSTITUTE FOR BIOLOGICAL STUDIES
 
<120> SONOGENETIC STIMULATION OF CELLS EXPRESSING TRPA1

<130> 167776.011401/PCT

<140> PCT/US2021/041814
<141> 2021-07-15

<150> 63/053,418
<151> 2020-07-17

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 1119
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val Pro Asp Asp Thr Glu Asp Phe 
            20                  25                  30          


Lys Glu Ser Leu Lys Val Val Phe Glu Gly Ser Ala Tyr Gly Leu Gln 
        35                  40                  45              


Asn Phe Asn Lys Gln Lys Lys Leu Lys Arg Cys Asp Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu Leu Met Glu 
65                  70                  75                  80  


Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His Glu Met Asp Asp 
                85                  90                  95      


Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn Gln Ile Glu 
            100                 105                 110         


Ser Val Lys Phe Leu Leu Ser Arg Gly Ala Asn Pro Asn Leu Arg Asn 
        115                 120                 125             


Phe Asn Met Met Ala Pro Leu His Ile Ala Val Gln Gly Met Asn Asn 
    130                 135                 140                 


Glu Val Met Lys Val Leu Leu Glu His Arg Thr Ile Asp Val Asn Leu 
145                 150                 155                 160 


Glu Gly Glu Asn Gly Asn Thr Ala Val Ile Ile Ala Cys Thr Thr Asn 
                165                 170                 175     


Asn Ser Glu Ala Leu Gln Ile Leu Leu Lys Lys Gly Ala Lys Pro Cys 
            180                 185                 190         


Lys Ser Asn Lys Trp Gly Cys Phe Pro Ile His Gln Ala Ala Phe Ser 
        195                 200                 205             


Gly Ser Lys Glu Cys Met Glu Ile Ile Leu Arg Phe Gly Glu Glu His 
    210                 215                 220                 


Gly Tyr Ser Arg Gln Leu His Ile Asn Phe Met Asn Asn Gly Lys Ala 
225                 230                 235                 240 


Thr Pro Leu His Leu Ala Val Gln Asn Gly Asp Leu Glu Met Ile Lys 
                245                 250                 255     


Met Cys Leu Asp Asn Gly Ala Gln Ile Asp Pro Val Glu Lys Gly Arg 
            260                 265                 270         


Cys Thr Ala Ile His Phe Ala Ala Thr Gln Gly Ala Thr Glu Ile Val 
        275                 280                 285             


Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile Val Asn Thr 
    290                 295                 300                 


Thr Asp Gly Cys His Glu Thr Met Leu His Arg Ala Ser Leu Phe Asp 
305                 310                 315                 320 


His His Glu Leu Ala Asp Tyr Leu Ile Ser Val Gly Ala Asp Ile Asn 
                325                 330                 335     


Lys Ile Asp Ser Glu Gly Arg Ser Pro Leu Ile Leu Ala Thr Ala Ser 
            340                 345                 350         


Ala Ser Trp Asn Ile Val Asn Leu Leu Leu Ser Lys Gly Ala Gln Val 
        355                 360                 365             


Asp Ile Lys Asp Asn Phe Gly Arg Asn Phe Leu His Leu Thr Val Gln 
    370                 375                 380                 


Gln Pro Tyr Gly Leu Lys Asn Leu Arg Pro Glu Phe Met Gln Met Gln 
385                 390                 395                 400 


Gln Ile Lys Glu Leu Val Met Asp Glu Asp Asn Asp Gly Cys Thr Pro 
                405                 410                 415     


Leu His Tyr Ala Cys Arg Gln Gly Gly Pro Gly Ser Val Asn Asn Leu 
            420                 425                 430         


Leu Gly Phe Asn Val Ser Ile His Ser Lys Ser Lys Asp Lys Lys Ser 
        435                 440                 445             


Pro Leu His Phe Ala Ala Ser Tyr Gly Arg Ile Asn Thr Cys Gln Arg 
    450                 455                 460                 


Leu Leu Gln Asp Ile Ser Asp Thr Arg Leu Leu Asn Glu Gly Asp Leu 
465                 470                 475                 480 


His Gly Met Thr Pro Leu His Leu Ala Ala Lys Asn Gly His Asp Lys 
                485                 490                 495     


Val Val Gln Leu Leu Leu Lys Lys Gly Ala Leu Phe Leu Ser Asp His 
            500                 505                 510         


Asn Gly Trp Thr Ala Leu His His Ala Ser Met Gly Gly Tyr Thr Gln 
        515                 520                 525             


Thr Met Lys Val Ile Leu Asp Thr Asn Leu Lys Cys Thr Asp Arg Leu 
    530                 535                 540                 


Asp Glu Asp Gly Asn Thr Ala Leu His Phe Ala Ala Arg Glu Gly His 
545                 550                 555                 560 


Ala Lys Ala Val Ala Leu Leu Leu Ser His Asn Ala Asp Ile Val Leu 
                565                 570                 575     


Asn Lys Gln Gln Ala Ser Phe Leu His Leu Ala Leu His Asn Lys Arg 
            580                 585                 590         


Lys Glu Val Val Leu Thr Ile Ile Arg Ser Lys Arg Trp Asp Glu Cys 
        595                 600                 605             


Leu Lys Ile Phe Ser His Asn Ser Pro Gly Asn Lys Cys Pro Ile Thr 
    610                 615                 620                 


Glu Met Ile Glu Tyr Leu Pro Glu Cys Met Lys Val Leu Leu Asp Phe 
625                 630                 635                 640 


Cys Met Leu His Ser Thr Glu Asp Lys Ser Cys Arg Asp Tyr Tyr Ile 
                645                 650                 655     


Glu Tyr Asn Phe Lys Tyr Leu Gln Cys Pro Leu Glu Phe Thr Lys Lys 
            660                 665                 670         


Thr Pro Thr Gln Asp Val Ile Tyr Glu Pro Leu Thr Ala Leu Asn Ala 
        675                 680                 685             


Met Val Gln Asn Asn Arg Ile Glu Leu Leu Asn His Pro Val Cys Lys 
    690                 695                 700                 


Glu Tyr Leu Leu Met Lys Trp Leu Ala Tyr Gly Phe Arg Ala His Met 
705                 710                 715                 720 


Met Asn Leu Gly Ser Tyr Cys Leu Gly Leu Ile Pro Met Thr Ile Leu 
                725                 730                 735     


Val Val Asn Ile Lys Pro Gly Met Ala Phe Asn Ser Thr Gly Ile Ile 
            740                 745                 750         


Asn Glu Thr Ser Asp His Ser Glu Ile Leu Asp Thr Thr Asn Ser Tyr 
        755                 760                 765             


Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser Ser Ile Phe Gly 
    770                 775                 780                 


Tyr Cys Lys Glu Ala Gly Gln Ile Phe Gln Gln Lys Arg Asn Tyr Phe 
785                 790                 795                 800 


Met Asp Ile Ser Asn Val Leu Glu Trp Ile Ile Tyr Thr Thr Gly Ile 
                805                 810                 815     


Ile Phe Val Leu Pro Leu Phe Val Glu Ile Pro Ala His Leu Gln Trp 
            820                 825                 830         


Gln Cys Gly Ala Ile Ala Val Tyr Phe Tyr Trp Met Asn Phe Leu Leu 
        835                 840                 845             


Tyr Leu Gln Arg Phe Glu Asn Cys Gly Ile Phe Ile Val Met Leu Glu 
    850                 855                 860                 


Val Ile Leu Lys Thr Leu Leu Arg Ser Thr Val Val Phe Ile Phe Leu 
865                 870                 875                 880 


Leu Leu Ala Phe Gly Leu Ser Phe Tyr Ile Leu Leu Asn Leu Gln Asp 
                885                 890                 895     


Pro Phe Ser Ser Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met 
            900                 905                 910         


Leu Gly Asp Ile Asn Tyr Arg Glu Ser Phe Leu Glu Pro Tyr Leu Arg 
        915                 920                 925             


Asn Glu Leu Ala His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe 
    930                 935                 940                 


Thr Ile Phe Val Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala 
945                 950                 955                 960 


Val Gly Asp Ile Ala Glu Val Gln Lys His Ala Ser Leu Lys Arg Ile 
                965                 970                 975     


Ala Met Gln Val Glu Leu His Thr Ser Leu Glu Lys Lys Leu Pro Leu 
            980                 985                 990         


Trp Phe Leu Arg Lys Val Asp Gln  Lys Ser Thr Ile Val  Tyr Pro Asn 
        995                 1000                 1005             


Lys Pro  Arg Ser Gly Gly Met  Leu Phe His Ile Phe  Cys Phe Leu 
    1010                 1015                 1020             


Phe Cys  Thr Gly Glu Ile Arg  Gln Glu Ile Pro Asn  Ala Asp Lys 
    1025                 1030                 1035             


Ser Leu  Glu Met Glu Ile Leu  Lys Gln Lys Tyr Arg  Leu Lys Asp 
    1040                 1045                 1050             


Leu Thr  Phe Leu Leu Glu Lys  Gln His Glu Leu Ile  Lys Leu Ile 
    1055                 1060                 1065             


Ile Gln  Lys Met Glu Ile Ile  Ser Glu Thr Glu Asp  Asp Asp Ser 
    1070                 1075                 1080             


His Cys  Ser Phe Gln Asp Arg  Phe Lys Lys Glu Gln  Met Glu Gln 
    1085                 1090                 1095             


Arg Asn  Ser Arg Trp Asn Thr  Val Leu Arg Ala Val  Lys Ala Lys 
    1100                 1105                 1110             


Thr His  His Leu Glu Pro 
    1115                 


<210> 2
<211> 1119
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val Pro Asp Asp Thr Glu Asp Phe 
            20                  25                  30          


Lys Glu Ser Leu Lys Val Val Phe Glu Gly Ser Ala Tyr Gly Leu Gln 
        35                  40                  45              


Asn Phe Asn Lys Gln Lys Lys Leu Lys Arg Cys Asp Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu Leu Met Glu 
65                  70                  75                  80  


Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His Glu Met Asp Asp 
                85                  90                  95      


Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn Gln Ile Glu 
            100                 105                 110         


Ser Val Lys Phe Leu Leu Ser Arg Gly Ala Asn Pro Asn Leu Arg Asn 
        115                 120                 125             


Phe Asn Met Met Ala Pro Leu His Ile Ala Val Gln Gly Met Asn Asn 
    130                 135                 140                 


Glu Val Met Lys Val Leu Leu Glu His Arg Thr Ile Asp Val Asn Leu 
145                 150                 155                 160 


Glu Gly Glu Asn Gly Asn Thr Ala Val Ile Ile Ala Cys Thr Thr Asn 
                165                 170                 175     


Asn Ser Glu Ala Leu Gln Ile Leu Leu Lys Lys Gly Ala Lys Pro Cys 
            180                 185                 190         


Lys Ser Asn Lys Trp Gly Cys Phe Pro Ile His Gln Ala Ala Phe Ser 
        195                 200                 205             


Gly Ser Lys Glu Cys Met Glu Ile Ile Leu Arg Phe Gly Glu Glu His 
    210                 215                 220                 


Gly Tyr Ser Arg Gln Leu His Ile Asn Phe Met Asn Asn Gly Lys Ala 
225                 230                 235                 240 


Thr Pro Leu His Leu Ala Val Gln Asn Gly Asp Leu Glu Met Ile Lys 
                245                 250                 255     


Met Cys Leu Asp Asn Gly Ala Gln Ile Asp Pro Val Glu Lys Gly Arg 
            260                 265                 270         


Cys Thr Ala Ile His Phe Ala Ala Thr Gln Gly Ala Thr Glu Ile Val 
        275                 280                 285             


Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile Val Asn Thr 
    290                 295                 300                 


Thr Asp Gly Cys His Glu Thr Met Leu His Arg Ala Ser Leu Phe Asp 
305                 310                 315                 320 


His His Glu Leu Ala Asp Tyr Leu Ile Ser Val Gly Ala Asp Ile Asn 
                325                 330                 335     


Lys Ile Asp Ser Glu Gly Arg Ser Pro Leu Ile Leu Ala Thr Ala Ser 
            340                 345                 350         


Ala Ser Trp Asn Ile Val Asn Leu Leu Leu Ser Lys Gly Ala Gln Val 
        355                 360                 365             


Asp Ile Lys Asp Asn Phe Gly Arg Asn Phe Leu His Leu Thr Val Gln 
    370                 375                 380                 


Gln Pro Tyr Gly Leu Lys Asn Leu Arg Pro Glu Phe Met Gln Met Gln 
385                 390                 395                 400 


Gln Ile Lys Glu Leu Val Met Asp Glu Asp Asn Asp Gly Cys Thr Pro 
                405                 410                 415     


Leu His Tyr Ala Cys Arg Gln Gly Gly Pro Gly Ser Val Asn Asn Leu 
            420                 425                 430         


Leu Gly Phe Asn Val Ser Ile His Ser Lys Ser Lys Asp Lys Lys Ser 
        435                 440                 445             


Pro Leu His Phe Ala Ala Ser Tyr Gly Arg Ile Asn Thr Cys Gln Arg 
    450                 455                 460                 


Leu Leu Gln Asp Ile Ser Asp Thr Arg Leu Leu Asn Glu Gly Asp Leu 
465                 470                 475                 480 


His Gly Met Thr Pro Leu His Leu Ala Ala Lys Asn Gly His Asp Lys 
                485                 490                 495     


Val Val Gln Leu Leu Leu Lys Lys Gly Ala Leu Phe Leu Ser Asp His 
            500                 505                 510         


Asn Gly Trp Thr Ala Leu His His Ala Ser Met Gly Gly Tyr Thr Gln 
        515                 520                 525             


Thr Met Lys Val Ile Leu Asp Thr Asn Leu Lys Cys Thr Asp Arg Leu 
    530                 535                 540                 


Asp Glu Asp Gly Asn Thr Ala Leu His Phe Ala Ala Arg Glu Gly His 
545                 550                 555                 560 


Ala Lys Ala Val Ala Leu Leu Leu Ser His Asn Ala Asp Ile Val Leu 
                565                 570                 575     


Asn Lys Gln Gln Ala Ser Phe Leu His Leu Ala Leu His Asn Lys Arg 
            580                 585                 590         


Lys Glu Val Val Leu Thr Ile Ile Arg Ser Lys Arg Trp Asp Glu Cys 
        595                 600                 605             


Leu Lys Ile Phe Ser His Asn Ser Pro Gly Asn Lys Cys Pro Ile Thr 
    610                 615                 620                 


Glu Met Ile Glu Tyr Leu Pro Glu Cys Met Lys Val Leu Leu Asp Phe 
625                 630                 635                 640 


Cys Met Leu His Ser Thr Glu Asp Lys Ser Cys Arg Asp Tyr Tyr Ile 
                645                 650                 655     


Glu Tyr Asn Phe Lys Tyr Leu Gln Cys Pro Leu Glu Phe Thr Lys Lys 
            660                 665                 670         


Thr Pro Thr Gln Asp Val Ile Tyr Glu Pro Leu Thr Ala Leu Asn Ala 
        675                 680                 685             


Met Val Gln Asn Asn Arg Ile Glu Leu Leu Asn His Pro Val Cys Lys 
    690                 695                 700                 


Glu Tyr Leu Leu Met Lys Trp Leu Ala Tyr Gly Phe Arg Ala His Met 
705                 710                 715                 720 


Met Asn Leu Gly Ser Tyr Cys Leu Gly Leu Ile Pro Met Thr Ile Leu 
                725                 730                 735     


Val Val Asn Ile Lys Pro Gly Met Ala Phe Asn Ser Thr Gly Ile Ile 
            740                 745                 750         


Asn Glu Thr Ser Asp His Ser Glu Ile Leu Asp Thr Thr Asn Ser Tyr 
        755                 760                 765             


Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser Ser Ile Phe Gly 
    770                 775                 780                 


Tyr Cys Lys Glu Ala Gly Gln Ile Phe Gln Gln Lys Arg Asn Tyr Phe 
785                 790                 795                 800 


Met Asp Ile Ser Asn Val Leu Glu Trp Ile Ile Tyr Thr Thr Gly Ile 
                805                 810                 815     


Ile Phe Val Leu Pro Leu Phe Val Glu Ile Pro Ala His Leu Gln Trp 
            820                 825                 830         


Gln Cys Gly Ala Ile Ala Val Tyr Phe Tyr Trp Met Asn Phe Leu Leu 
        835                 840                 845             


Tyr Leu Gln Arg Phe Glu Asn Cys Gly Ile Phe Ile Val Met Leu Glu 
    850                 855                 860                 


Val Ile Leu Lys Thr Leu Leu Arg Ser Thr Val Val Phe Ile Phe Leu 
865                 870                 875                 880 


Leu Leu Ala Phe Gly Leu Ser Phe Tyr Ile Leu Leu Asn Leu Gln Asp 
                885                 890                 895     


Pro Phe Ser Ser Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met 
            900                 905                 910         


Leu Gly Asp Ile Asn Tyr Arg Glu Ser Phe Leu Glu Pro Tyr Leu Arg 
        915                 920                 925             


Asn Glu Leu Ala His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe 
    930                 935                 940                 


Thr Ile Phe Val Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala 
945                 950                 955                 960 


Val Gly Asp Ile Ala Glu Val Gln Lys His Ala Ser Leu Lys Arg Ile 
                965                 970                 975     


Ala Met Gln Val Glu Leu His Thr Ser Leu Glu Lys Lys Leu Pro Leu 
            980                 985                 990         


Trp Phe Leu Arg Lys Val Asp Gln  Lys Ser Thr Ile Val  Tyr Pro Asn 
        995                 1000                 1005             


Lys Pro  Arg Ser Gly Gly Met  Leu Phe His Ile Phe  Cys Phe Leu 
    1010                 1015                 1020             


Phe Cys  Thr Gly Glu Ile Arg  Gln Glu Ile Pro Asn  Ala Asp Lys 
    1025                 1030                 1035             


Ser Leu  Glu Met Glu Ile Leu  Lys Gln Lys Tyr Arg  Leu Lys Asp 
    1040                 1045                 1050             


Leu Thr  Phe Leu Leu Glu Lys  Gln His Glu Leu Ile  Lys Leu Ile 
    1055                 1060                 1065             


Ile Gln  Lys Met Glu Ile Ile  Ser Glu Thr Glu Asp  Asp Asp Ser 
    1070                 1075                 1080             


His Cys  Ser Phe Gln Asp Arg  Phe Lys Lys Glu Gln  Met Glu Gln 
    1085                 1090                 1095             


Arg Asn  Ser Arg Trp Asn Thr  Val Leu Arg Ala Val  Lys Ala Lys 
    1100                 1105                 1110             


Thr His  His Leu Glu Pro 
    1115                 


<210> 3
<211> 5191
<212> DNA
<213> Homo sapiens

<400> 3
ccagaagttc tccagggctt ccgcagagcg actttttcgc tgcctgtgag ctgcagcgcg       60

ggagagctcg ggctcgcgcg gaccccagcg cctggcaggc tgacagcgct ctctcgcccc      120

aggtgcccgc gcgcgtggtg agcagctgca ccaggtggcg tccggggtgg ggtcaatgaa      180

gcgcagcctg aggaagatgt ggcgccctgg agaaaagaag gagccccagg gcgttgtcta      240

tgaggatgtg ccggacgaca cggaggattt caaggaatcg cttaaggtgg tttttgaagg      300

aagtgcatat ggattacaaa actttaataa gcaaaagaaa ttaaaaagat gtgacgatat      360

ggacaccttc ttcttgcatt atgctgcagc agaaggccaa attgagctaa tggagaagat      420

caccagagat tcctctttgg aagtgctgca tgaaatggat gattatggaa atacccctct      480

gcattgtgct gtagaaaaaa accaaattga aagcgttaag tttcttctca gcagaggagc      540

aaacccaaat ctccgaaact tcaacatgat ggctcctctc cacatagctg tgcagggcat      600

gaataatgag gtgatgaagg tcttgcttga gcatagaact attgatgtta atttggaagg      660

agaaaatgga aacacagctg tgatcattgc gtgcaccaca aataatagcg aagcattgca      720

gattttgctt aaaaaaggag ctaagccatg taaatcaaat aaatggggat gtttccctat      780

tcaccaagct gcattttcag gttccaaaga atgcatggaa ataatactaa ggtttggtga      840

agagcatggg tacagtagac agttgcacat taactttatg aataatggga aagccacccc      900

tctccacctg gctgtgcaaa atggtgactt ggaaatgatc aaaatgtgcc tggacaatgg      960

tgcacaaata gacccagtgg agaagggaag gtgcacagcc attcattttg ctgccaccca     1020

gggagccact gagattgtta aactgatgat atcgtcctat tctggtagcg tggatattgt     1080

taacacaacc gatggatgtc atgagaccat gcttcacaga gcttcattgt ttgatcacca     1140

tgagctagca gactatttaa tttcagtggg agcagatatt aataagatcg attctgaagg     1200

acgctctcca cttatattag caactgcttc tgcatcttgg aatattgtaa atttgctact     1260

ctctaaaggt gcccaagtag acataaaaga taattttgga cgtaattttc tgcatttaac     1320

tgtacagcaa ccttatggat taaaaaatct gcgacctgaa tttatgcaga tgcaacagat     1380

caaagagctg gtaatggatg aagacaacga tgggtgtact cctctacatt atgcatgtag     1440

acaggggggc cctggttctg taaataacct acttggcttt aatgtgtcca ttcattccaa     1500

aagcaaagat aagaaatcac ctctgcattt tgcagccagt tatgggcgta tcaatacctg     1560

tcagaggctc ctacaagaca taagtgatac gaggcttctg aatgaaggtg accttcatgg     1620

aatgactcct ctccatctgg cagcaaagaa tggacatgat aaagtagttc agcttcttct     1680

gaaaaaaggt gcattgtttc tcagtgacca caatggctgg acagctttgc atcatgcgtc     1740

catgggcggg tacactcaga ccatgaaggt cattcttgat actaatttga agtgcacaga     1800

tcgcctggat gaagacggga acactgcact tcactttgct gcaagggaag gccacgccaa     1860

agccgttgcg cttcttctga gccacaatgc tgacatagtc ctgaacaagc agcaggcctc     1920

ctttttgcac cttgcacttc acaataagag gaaggaggtt gttcttacga tcatcaggag     1980

caaaagatgg gatgaatgtc ttaagatttt cagtcataat tctccaggca ataaatgtcc     2040

aattacagaa atgatagaat acctccctga atgcatgaag gtacttttag atttctgcat     2100

gttgcattcc acagaagaca agtcctgccg agactattat atcgagtata atttcaaata     2160

tcttcaatgt ccattagaat tcaccaaaaa aacacctaca caggatgtta tatatgaacc     2220

gcttacagcc ctcaacgcaa tggtacaaaa taaccgcata gagcttctca atcatcctgt     2280

gtgtaaagaa tatttactca tgaaatggtt ggcttatgga tttagagctc atatgatgaa     2340

tttaggatct tactgtcttg gtctcatacc tatgaccatt ctcgttgtca atataaaacc     2400

aggaatggct ttcaactcaa ctggcatcat caatgaaact agtgatcatt cagaaatact     2460

agataccacg aattcatatc taataaaaac ttgtatgatt ttagtgtttt tatcaagtat     2520

atttgggtat tgcaaagaag cggggcaaat tttccaacag aaaaggaatt attttatgga     2580

tataagcaat gttcttgaat ggattatcta cacgacgggc atcatttttg tgctgccctt     2640

gtttgttgaa ataccagctc atctgcagtg gcaatgtgga gcaattgctg tttacttcta     2700

ttggatgaat ttcttattgt atcttcaaag atttgaaaat tgtggaattt ttattgttat     2760

gttggaggta attttgaaaa ctttgttgag gtctacagtt gtatttatct tccttcttct     2820

ggcttttgga ctcagctttt acatcctcct gaatttacag gatcccttca gctctccatt     2880

gctttctata atccagacct tcagcatgat gctaggagat atcaattatc gagagtcctt     2940

cctagaacca tatctgagaa atgaattggc acatccagtt ctgtcctttg cacaacttgt     3000

ttccttcaca atatttgtcc caattgtcct catgaattta cttattggtt tggcagttgg     3060

cgacattgct gaggtccaga aacatgcatc attgaagagg atagctatgc aggtggaact     3120

tcataccagc ttagagaaga agctgccact ttggtttcta cgcaaagtgg atcagaaatc     3180

caccatcgtg tatcccaaca aacccagatc tggtgggatg ttattccata tattctgttt     3240

tttattttgc actggggaaa taagacaaga aataccaaat gctgataaat ctttagaaat     3300

ggaaatatta aagcagaaat accggctgaa ggatcttact tttctcctgg aaaaacagca     3360

tgagctcatt aaactgatca ttcagaagat ggagatcatc tctgagacag aggatgatga     3420

tagccattgt tcttttcaag acaggtttaa gaaagagcag atggaacaaa ggaatagcag     3480

atggaatact gtgttgagag cagtcaaggc aaaaacacac catcttgagc cttagctcct     3540

cagaccttca gtgaggcttc taatgggggg tgcatgactt gctggttcta actttcaatt     3600

taaaaagagt gaggaagaag cagaatgatt cattttgctg cgtgtgaaat catggttcct     3660

gcatgctgta taaaagtaaa ccatctttta tcctctattc atattttcta ccaatcacta     3720

tgtattgggg atatctttgc agatatgttc aaattggact ggactttgat gagatataat     3780

ctcattattt gaatgggtag aaaatgaatt tgctagaaca cacattttta atgaaaagaa     3840

gtaataaatg taactattaa gctaaaatgc aaatgtcagt actgaattcc tgcttgttaa     3900

ttacataata tgtgatgctc tagaaaatag tcacaagtat taataatgcc ttagatgata     3960

gtcttaaata ttaggttgag gtctacctaa cctaagctgc ttcctggaaa gcttcatgtt     4020

gaaagaacct atgggtggca ccatgtggac ttttctgtcc ctactgtgat gaatagcccc     4080

acccttcttg ctgtccccaa cacacctgat gtcactttga gccatatagt tgaagtacaa     4140

attaataggc cttatgatat gcacgaattt tactatagat aatatatgtt gtttctggtt     4200

ttgtttgcca atgagcataa taaatgtaaa acctatatag tatccctgtg attattgtat     4260

gagcctttgt ttgagatttg aaaacaacat ggctccatca catattccct tttttctttt     4320

gatgtctact caaatcatga attaatcaca tacctcatca ttaatctttt caaggtcctt     4380

ctattgtttt gtctgatttt ctccatcatc ctgattagca tgtttattcc ctcactaccc     4440

ccaggagata ttcactgtaa tgaatatgtc tttggctatg tatgtgtcct tgtgttatgt     4500

tgtacagtgt tgttttgagt ctgttattat ttacacagat gttattatgc tatagcttct     4560

atttctgttt ttgcttctta tttctcttat aattctcact tatttcctat tttttctact     4620

catttctatt tgttactcct ttttactgga catgatgttt acaagataca actgtgttac     4680

tgtattccat ctagtacggg gcctttggtg tggcttacta tttcattgtg tgcacccacc     4740

cacccaccac actggacttt tctagagatg gacagcttgg ttacctccac cttcctgcac     4800

tcattctcaa acatactgat gttcatacaa accagcagag tgctgaggga cgatatgtac     4860

tattacaaaa ccagacactt ttacattcat ggtccaacag atcacatggc ctagaggcaa     4920

tgttgcatat accttaatct ttgatatgaa taatatcttt gttctttata tttcttaaaa     4980

cagaaagggt ggaaaatcac tatacagaag caatatccaa agatctcctg atcataaaga     5040

caaggggtct tttcagtctt ccctctcctc aaaccttgtg tagcattgca caatatagat     5100

ctcagtcaac attcactgag tgccaagaat gtgagaaaca ctgtaccatg cctgtcatgc     5160

gaaatattta aataaacaga ttgtcttaca a                                    5191


<210> 4
<211> 1119
<212> PRT
<213> Homo sapiens

<400> 4
Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val Pro Asp Asp Thr Glu Asp Phe 
            20                  25                  30          


Lys Glu Ser Leu Lys Val Val Phe Glu Gly Ser Ala Tyr Gly Leu Gln 
        35                  40                  45              


Asn Phe Asn Lys Gln Lys Lys Leu Lys Arg Cys Asp Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu Leu Met Glu 
65                  70                  75                  80  


Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His Glu Met Asp Asp 
                85                  90                  95      


Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn Gln Ile Glu 
            100                 105                 110         


Ser Val Lys Phe Leu Leu Ser Arg Gly Ala Asn Pro Asn Leu Arg Asn 
        115                 120                 125             


Phe Asn Met Met Ala Pro Leu His Ile Ala Val Gln Gly Met Asn Asn 
    130                 135                 140                 


Glu Val Met Lys Val Leu Leu Glu His Arg Thr Ile Asp Val Asn Leu 
145                 150                 155                 160 


Glu Gly Glu Asn Gly Asn Thr Ala Val Ile Ile Ala Cys Thr Thr Asn 
                165                 170                 175     


Asn Ser Glu Ala Leu Gln Ile Leu Leu Lys Lys Gly Ala Lys Pro Cys 
            180                 185                 190         


Lys Ser Asn Lys Trp Gly Cys Phe Pro Ile His Gln Ala Ala Phe Ser 
        195                 200                 205             


Gly Ser Lys Glu Cys Met Glu Ile Ile Leu Arg Phe Gly Glu Glu His 
    210                 215                 220                 


Gly Tyr Ser Arg Gln Leu His Ile Asn Phe Met Asn Asn Gly Lys Ala 
225                 230                 235                 240 


Thr Pro Leu His Leu Ala Val Gln Asn Gly Asp Leu Glu Met Ile Lys 
                245                 250                 255     


Met Cys Leu Asp Asn Gly Ala Gln Ile Asp Pro Val Glu Lys Gly Arg 
            260                 265                 270         


Cys Thr Ala Ile His Phe Ala Ala Thr Gln Gly Ala Thr Glu Ile Val 
        275                 280                 285             


Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile Val Asn Thr 
    290                 295                 300                 


Thr Asp Gly Cys His Glu Thr Met Leu His Arg Ala Ser Leu Phe Asp 
305                 310                 315                 320 


His His Glu Leu Ala Asp Tyr Leu Ile Ser Val Gly Ala Asp Ile Asn 
                325                 330                 335     


Lys Ile Asp Ser Glu Gly Arg Ser Pro Leu Ile Leu Ala Thr Ala Ser 
            340                 345                 350         


Ala Ser Trp Asn Ile Val Asn Leu Leu Leu Ser Lys Gly Ala Gln Val 
        355                 360                 365             


Asp Ile Lys Asp Asn Phe Gly Arg Asn Phe Leu His Leu Thr Val Gln 
    370                 375                 380                 


Gln Pro Tyr Gly Leu Lys Asn Leu Arg Pro Glu Phe Met Gln Met Gln 
385                 390                 395                 400 


Gln Ile Lys Glu Leu Val Met Asp Glu Asp Asn Asp Gly Cys Thr Pro 
                405                 410                 415     


Leu His Tyr Ala Cys Arg Gln Gly Gly Pro Gly Ser Val Asn Asn Leu 
            420                 425                 430         


Leu Gly Phe Asn Val Ser Ile His Ser Lys Ser Lys Asp Lys Lys Ser 
        435                 440                 445             


Pro Leu His Phe Ala Ala Ser Tyr Gly Arg Ile Asn Thr Cys Gln Arg 
    450                 455                 460                 


Leu Leu Gln Asp Ile Ser Asp Thr Arg Leu Leu Asn Glu Gly Asp Leu 
465                 470                 475                 480 


His Gly Met Thr Pro Leu His Leu Ala Ala Lys Asn Gly His Asp Lys 
                485                 490                 495     


Val Val Gln Leu Leu Leu Lys Lys Gly Ala Leu Phe Leu Ser Asp His 
            500                 505                 510         


Asn Gly Trp Thr Ala Leu His His Ala Ser Met Gly Gly Tyr Thr Gln 
        515                 520                 525             


Thr Met Lys Val Ile Leu Asp Thr Asn Leu Lys Cys Thr Asp Arg Leu 
    530                 535                 540                 


Asp Glu Asp Gly Asn Thr Ala Leu His Phe Ala Ala Arg Glu Gly His 
545                 550                 555                 560 


Ala Lys Ala Val Ala Leu Leu Leu Ser His Asn Ala Asp Ile Val Leu 
                565                 570                 575     


Asn Lys Gln Gln Ala Ser Phe Leu His Leu Ala Leu His Asn Lys Arg 
            580                 585                 590         


Lys Glu Val Val Leu Thr Ile Ile Arg Ser Lys Arg Trp Asp Glu Cys 
        595                 600                 605             


Leu Lys Ile Phe Ser His Asn Ser Pro Gly Asn Lys Cys Pro Ile Thr 
    610                 615                 620                 


Glu Met Ile Glu Tyr Leu Pro Glu Cys Met Lys Val Leu Leu Asp Phe 
625                 630                 635                 640 


Cys Met Leu His Ser Thr Glu Asp Lys Ser Cys Arg Asp Tyr Tyr Ile 
                645                 650                 655     


Glu Tyr Asn Phe Lys Tyr Leu Gln Cys Pro Leu Glu Phe Thr Lys Lys 
            660                 665                 670         


Thr Pro Thr Gln Asp Val Ile Tyr Glu Pro Leu Thr Ala Leu Asn Ala 
        675                 680                 685             


Met Val Gln Asn Asn Arg Ile Glu Leu Leu Asn His Pro Val Cys Lys 
    690                 695                 700                 


Glu Tyr Leu Leu Met Lys Trp Leu Ala Tyr Gly Phe Arg Ala His Met 
705                 710                 715                 720 


Met Asn Leu Gly Ser Tyr Cys Leu Gly Leu Ile Pro Met Thr Ile Leu 
                725                 730                 735     


Val Val Asn Ile Lys Pro Gly Met Ala Phe Asn Ser Thr Gly Ile Ile 
            740                 745                 750         


Asn Glu Thr Ser Asp His Ser Glu Ile Leu Asp Thr Thr Asn Ser Tyr 
        755                 760                 765             


Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser Ser Ile Phe Gly 
    770                 775                 780                 


Tyr Cys Lys Glu Ala Gly Gln Ile Phe Gln Gln Lys Arg Asn Tyr Phe 
785                 790                 795                 800 


Met Asp Ile Ser Asn Val Leu Glu Trp Ile Ile Tyr Thr Thr Gly Ile 
                805                 810                 815     


Ile Phe Val Leu Pro Leu Phe Val Glu Ile Pro Ala His Leu Gln Trp 
            820                 825                 830         


Gln Cys Gly Ala Ile Ala Val Tyr Phe Tyr Trp Met Asn Phe Leu Leu 
        835                 840                 845             


Tyr Leu Gln Arg Phe Glu Asn Cys Gly Ile Phe Ile Val Met Leu Glu 
    850                 855                 860                 


Val Ile Leu Lys Thr Leu Leu Arg Ser Thr Val Val Phe Ile Phe Leu 
865                 870                 875                 880 


Leu Leu Ala Phe Gly Leu Ser Phe Tyr Ile Leu Leu Asn Leu Gln Asp 
                885                 890                 895     


Pro Phe Ser Ser Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met 
            900                 905                 910         


Leu Gly Asp Ile Asn Tyr Arg Glu Ser Phe Leu Glu Pro Tyr Leu Arg 
        915                 920                 925             


Asn Glu Leu Ala His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe 
    930                 935                 940                 


Thr Ile Phe Val Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala 
945                 950                 955                 960 


Val Gly Asp Ile Ala Glu Val Gln Lys His Ala Ser Leu Lys Arg Ile 
                965                 970                 975     


Ala Met Gln Val Glu Leu His Thr Ser Leu Glu Lys Lys Leu Pro Leu 
            980                 985                 990         


Trp Phe Leu Arg Lys Val Asp Gln  Lys Ser Thr Ile Val  Tyr Pro Asn 
        995                 1000                 1005             


Lys Pro  Arg Ser Gly Gly Met  Leu Phe His Ile Phe  Cys Phe Leu 
    1010                 1015                 1020             


Phe Cys  Thr Gly Glu Ile Arg  Gln Glu Ile Pro Asn  Ala Asp Lys 
    1025                 1030                 1035             


Ser Leu  Glu Met Glu Ile Leu  Lys Gln Lys Tyr Arg  Leu Lys Asp 
    1040                 1045                 1050             


Leu Thr  Phe Leu Leu Glu Lys  Gln His Glu Leu Ile  Lys Leu Ile 
    1055                 1060                 1065             


Ile Gln  Lys Met Glu Ile Ile  Ser Glu Thr Glu Asp  Asp Asp Ser 
    1070                 1075                 1080             


His Cys  Ser Phe Gln Asp Arg  Phe Lys Lys Glu Gln  Met Glu Gln 
    1085                 1090                 1095             


Arg Asn  Ser Arg Trp Asn Thr  Val Leu Arg Ala Val  Lys Ala Lys 
    1100                 1105                 1110             


Thr His  His Leu Glu Pro 
    1115                 


<210> 5
<211> 1119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val Pro Asp Asp Thr Glu Asp Phe 
            20                  25                  30          


Lys Glu Ser Leu Lys Val Val Phe Glu Gly Ser Ala Tyr Gly Leu Gln 
        35                  40                  45              


Asn Phe Asn Lys Gln Lys Lys Leu Lys Arg Cys Asp Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu Leu Met Glu 
65                  70                  75                  80  


Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His Glu Met Asp Asp 
                85                  90                  95      


Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn Gln Ile Glu 
            100                 105                 110         


Ser Val Lys Phe Leu Leu Ser Arg Gly Ala Asn Pro Asn Leu Arg Asn 
        115                 120                 125             


Phe Asn Met Met Ala Pro Leu His Ile Ala Val Gln Gly Met Asn Asn 
    130                 135                 140                 


Glu Val Met Lys Val Leu Leu Glu His Arg Thr Ile Asp Val Asn Leu 
145                 150                 155                 160 


Glu Gly Glu Asn Gly Asn Thr Ala Val Ile Ile Ala Cys Thr Thr Asn 
                165                 170                 175     


Asn Ser Glu Ala Leu Gln Ile Leu Leu Lys Lys Gly Ala Lys Pro Cys 
            180                 185                 190         


Lys Ser Asn Lys Trp Gly Cys Phe Pro Ile His Gln Ala Ala Phe Ser 
        195                 200                 205             


Gly Ser Lys Glu Cys Met Glu Ile Ile Leu Arg Phe Gly Glu Glu His 
    210                 215                 220                 


Gly Tyr Ser Arg Gln Leu His Ile Asn Phe Met Asn Asn Gly Lys Ala 
225                 230                 235                 240 


Thr Pro Leu His Leu Ala Val Gln Asn Gly Asp Leu Glu Met Ile Lys 
                245                 250                 255     


Met Cys Leu Asp Asn Gly Ala Gln Ile Asp Pro Val Glu Lys Gly Arg 
            260                 265                 270         


Cys Thr Ala Ile His Phe Ala Ala Thr Gln Gly Ala Thr Glu Ile Val 
        275                 280                 285             


Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile Val Asn Thr 
    290                 295                 300                 


Thr Asp Gly Cys His Glu Thr Met Leu His Arg Ala Ser Leu Phe Asp 
305                 310                 315                 320 


His His Glu Leu Ala Asp Tyr Leu Ile Ser Val Gly Ala Asp Ile Asn 
                325                 330                 335     


Lys Ile Asp Ser Glu Gly Arg Ser Pro Leu Ile Leu Ala Thr Ala Ser 
            340                 345                 350         


Ala Ser Trp Asn Ile Val Asn Leu Leu Leu Ser Lys Gly Ala Gln Val 
        355                 360                 365             


Asp Ile Lys Asp Asn Phe Gly Arg Asn Phe Leu His Leu Thr Val Gln 
    370                 375                 380                 


Gln Pro Tyr Gly Leu Lys Asn Leu Arg Pro Glu Phe Met Gln Met Gln 
385                 390                 395                 400 


Gln Ile Lys Glu Leu Val Met Asp Glu Asp Asn Asp Gly Cys Thr Pro 
                405                 410                 415     


Leu His Tyr Ala Cys Arg Gln Gly Gly Pro Gly Ser Val Asn Asn Leu 
            420                 425                 430         


Leu Gly Phe Asn Val Ser Ile His Ser Lys Ser Lys Asp Lys Lys Ser 
        435                 440                 445             


Pro Leu His Phe Ala Ala Ser Tyr Gly Arg Ile Asn Thr Cys Gln Arg 
    450                 455                 460                 


Leu Leu Gln Asp Ile Ser Asp Thr Arg Leu Leu Asn Glu Gly Asp Leu 
465                 470                 475                 480 


His Gly Met Thr Pro Leu His Leu Ala Ala Lys Asn Gly His Asp Lys 
                485                 490                 495     


Val Val Gln Leu Leu Leu Lys Lys Gly Ala Leu Phe Leu Ser Asp His 
            500                 505                 510         


Asn Gly Trp Thr Ala Leu His His Ala Ser Met Gly Gly Tyr Thr Gln 
        515                 520                 525             


Thr Met Lys Val Ile Leu Asp Thr Asn Leu Lys Cys Thr Asp Arg Leu 
    530                 535                 540                 


Asp Glu Asp Gly Asn Thr Ala Leu His Phe Ala Ala Arg Glu Gly His 
545                 550                 555                 560 


Ala Lys Ala Val Ala Leu Leu Leu Ser His Asn Ala Asp Ile Val Leu 
                565                 570                 575     


Asn Lys Gln Gln Ala Ser Phe Leu His Leu Ala Leu His Asn Lys Arg 
            580                 585                 590         


Lys Glu Val Val Leu Thr Ile Ile Arg Ser Lys Arg Trp Asp Glu Cys 
        595                 600                 605             


Leu Lys Ile Phe Ser His Asn Ser Pro Gly Asn Lys Cys Pro Ile Thr 
    610                 615                 620                 


Glu Met Ile Glu Tyr Leu Pro Glu Cys Met Lys Val Leu Leu Asp Phe 
625                 630                 635                 640 


Cys Met Leu His Ser Thr Glu Asp Lys Ser Cys Arg Asp Tyr Tyr Ile 
                645                 650                 655     


Glu Tyr Asn Phe Lys Tyr Leu Gln Cys Pro Leu Glu Phe Thr Lys Lys 
            660                 665                 670         


Thr Pro Thr Gln Asp Val Ile Tyr Glu Pro Leu Thr Ala Leu Asn Ala 
        675                 680                 685             


Met Val Gln Asn Asn Arg Ile Glu Leu Leu Asn His Pro Val Cys Lys 
    690                 695                 700                 


Glu Tyr Leu Leu Met Lys Trp Leu Ala Tyr Gly Phe Arg Ala His Met 
705                 710                 715                 720 


Met Asn Leu Gly Ser Tyr Cys Leu Gly Leu Ile Pro Met Thr Ile Leu 
                725                 730                 735     


Val Val Asn Ile Lys Pro Gly Met Ala Phe Asn Ser Thr Gly Ile Ile 
            740                 745                 750         


Asn Glu Thr Ser Asp His Ser Glu Ile Leu Asp Thr Thr Asn Ser Tyr 
        755                 760                 765             


Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser Ser Ile Phe Gly 
    770                 775                 780                 


Tyr Cys Lys Glu Ala Gly Gln Ile Phe Gln Gln Lys Arg Asn Tyr Phe 
785                 790                 795                 800 


Met Asp Ile Ser Asn Val Leu Glu Trp Ile Ile Tyr Thr Thr Gly Ile 
                805                 810                 815     


Ile Phe Val Leu Pro Leu Phe Val Glu Ile Pro Ala His Leu Gln Trp 
            820                 825                 830         


Gln Cys Gly Ala Ile Ala Val Tyr Phe Tyr Trp Met Asn Phe Leu Leu 
        835                 840                 845             


Tyr Leu Gln Arg Phe Glu Asn Cys Gly Ile Phe Ile Val Met Leu Glu 
    850                 855                 860                 


Val Ile Leu Lys Thr Leu Leu Arg Ser Thr Val Val Phe Ile Phe Leu 
865                 870                 875                 880 


Leu Leu Ala Phe Gly Leu Ser Phe Tyr Ile Leu Leu Asn Leu Gln Asp 
                885                 890                 895     


Pro Phe Ser Ser Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met 
            900                 905                 910         


Leu Gly Asp Ile Asn Tyr Arg Glu Ser Phe Leu His Pro Tyr Leu Arg 
        915                 920                 925             


Asn Glu Leu Ala His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe 
    930                 935                 940                 


Thr Ile Phe Val Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala 
945                 950                 955                 960 


Val Gly Asp Ile Ala Glu Val Gln Lys His Ala Ser Leu Lys Arg Ile 
                965                 970                 975     


Ala Met Gln Val Glu Leu His Thr Ser Leu Glu Lys Lys Leu Pro Leu 
            980                 985                 990         


Trp Phe Leu Arg Lys Val Asp Gln  Lys Ser Thr Ile Val  Tyr Pro Asn 
        995                 1000                 1005             


Lys Pro  Arg Ser Gly Gly Met  Leu Phe His Ile Phe  Cys Phe Leu 
    1010                 1015                 1020             


Phe Cys  Thr Gly Glu Ile Arg  Gln Glu Ile Pro Asn  Ala Asp Lys 
    1025                 1030                 1035             


Ser Leu  Glu Met Glu Ile Leu  Lys Gln Lys Tyr Arg  Leu Lys Asp 
    1040                 1045                 1050             


Leu Thr  Phe Leu Leu Glu Lys  Gln His Glu Leu Ile  Lys Leu Ile 
    1055                 1060                 1065             


Ile Gln  Lys Met Glu Ile Ile  Ser Glu Thr Glu Asp  Asp Asp Ser 
    1070                 1075                 1080             


His Cys  Ser Phe Gln Asp Arg  Phe Lys Lys Glu Gln  Met Glu Gln 
    1085                 1090                 1095             


Arg Asn  Ser Arg Trp Asn Thr  Val Leu Arg Ala Val  Lys Ala Lys 
    1100                 1105                 1110             


Thr His  His Leu Glu Pro 
    1115                 


<210> 6
<211> 1105
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val Pro Asp Asp Thr Glu Asp Phe 
            20                  25                  30          


Lys Glu Ser Leu Lys Val Val Phe Glu Gly Ser Ala Tyr Gly Leu Gln 
        35                  40                  45              


Asn Phe Asn Lys Gln Lys Lys Leu Lys Arg Cys Asp Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu Leu Met Glu 
65                  70                  75                  80  


Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His Glu Met Asp Asp 
                85                  90                  95      


Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn Gln Ile Glu 
            100                 105                 110         


Ser Val Lys Phe Leu Leu Ser Arg Gly Ala Asn Pro Asn Leu Arg Asn 
        115                 120                 125             


Phe Asn Met Met Ala Pro Leu His Ile Ala Val Gln Gly Met Asn Asn 
    130                 135                 140                 


Glu Val Met Lys Val Leu Leu Glu His Arg Thr Ile Asp Val Asn Leu 
145                 150                 155                 160 


Glu Gly Glu Asn Gly Asn Thr Ala Val Ile Ile Ala Cys Thr Thr Asn 
                165                 170                 175     


Asn Ser Glu Ala Leu Gln Ile Leu Leu Lys Lys Gly Ala Lys Pro Cys 
            180                 185                 190         


Lys Ser Asn Lys Trp Gly Cys Phe Pro Ile His Gln Ala Ala Phe Ser 
        195                 200                 205             


Gly Ser Lys Glu Cys Met Glu Ile Ile Leu Arg Phe Gly Glu Glu His 
    210                 215                 220                 


Gly Tyr Ser Arg Gln Leu His Ile Asn Phe Met Asn Asn Gly Lys Ala 
225                 230                 235                 240 


Thr Pro Leu His Leu Ala Val Gln Asn Gly Asp Leu Glu Met Ile Lys 
                245                 250                 255     


Met Cys Leu Asp Asn Gly Ala Gln Ile Asp Pro Val Glu Lys Gly Arg 
            260                 265                 270         


Cys Thr Ala Ile His Phe Ala Ala Thr Gln Gly Ala Thr Glu Ile Val 
        275                 280                 285             


Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile Val Asn Thr 
    290                 295                 300                 


Thr Asp Gly Cys His Glu Thr Met Leu His Arg Ala Ser Leu Phe Asp 
305                 310                 315                 320 


His His Glu Leu Ala Asp Tyr Leu Ile Ser Val Gly Ala Asp Ile Asn 
                325                 330                 335     


Lys Ile Asp Ser Glu Gly Arg Ser Pro Leu Ile Leu Ala Thr Ala Ser 
            340                 345                 350         


Ala Ser Trp Asn Ile Val Asn Leu Leu Leu Ser Lys Gly Ala Gln Val 
        355                 360                 365             


Asp Ile Lys Asp Asn Phe Gly Arg Asn Phe Leu His Leu Thr Val Gln 
    370                 375                 380                 


Gln Pro Tyr Gly Leu Lys Asn Leu Arg Pro Glu Phe Met Gln Met Gln 
385                 390                 395                 400 


Gln Ile Lys Glu Leu Val Met Asp Glu Asp Asn Asp Gly Cys Thr Pro 
                405                 410                 415     


Leu His Tyr Ala Cys Arg Gln Gly Gly Pro Gly Ser Val Asn Asn Leu 
            420                 425                 430         


Leu Gly Phe Asn Val Ser Ile His Ser Lys Ser Lys Asp Lys Lys Ser 
        435                 440                 445             


Pro Leu His Phe Ala Ala Ser Tyr Gly Arg Ile Asn Thr Cys Gln Arg 
    450                 455                 460                 


Leu Leu Gln Asp Ile Ser Asp Thr Arg Leu Leu Asn Glu Gly Asp Leu 
465                 470                 475                 480 


His Gly Met Thr Pro Leu His Leu Ala Ala Lys Asn Gly His Asp Lys 
                485                 490                 495     


Val Val Gln Leu Leu Leu Lys Lys Gly Ala Leu Phe Leu Ser Asp His 
            500                 505                 510         


Asn Gly Trp Thr Ala Leu His His Ala Ser Met Gly Gly Tyr Thr Gln 
        515                 520                 525             


Thr Met Lys Val Ile Leu Asp Thr Asn Leu Lys Cys Thr Asp Arg Leu 
    530                 535                 540                 


Asp Glu Asp Gly Asn Thr Ala Leu His Phe Ala Ala Arg Glu Gly His 
545                 550                 555                 560 


Ala Lys Ala Val Ala Leu Leu Leu Ser His Asn Ala Asp Ile Val Leu 
                565                 570                 575     


Asn Lys Gln Gln Ala Ser Phe Leu His Leu Ala Leu His Asn Lys Arg 
            580                 585                 590         


Lys Glu Val Val Leu Thr Ile Ile Arg Ser Lys Arg Trp Asp Glu Cys 
        595                 600                 605             


Leu Lys Ile Phe Ser His Asn Ser Pro Gly Asn Lys Cys Pro Ile Thr 
    610                 615                 620                 


Glu Met Ile Glu Tyr Leu Pro Glu Cys Met Lys Val Leu Leu Asp Phe 
625                 630                 635                 640 


Cys Met Leu His Ser Thr Glu Asp Lys Ser Cys Arg Asp Tyr Tyr Ile 
                645                 650                 655     


Glu Tyr Asn Phe Lys Tyr Leu Gln Cys Pro Leu Glu Phe Thr Lys Lys 
            660                 665                 670         


Thr Pro Thr Gln Asp Val Ile Tyr Glu Pro Leu Thr Ala Leu Asn Ala 
        675                 680                 685             


Met Val Gln Asn Asn Arg Ile Glu Leu Leu Asn His Pro Val Cys Lys 
    690                 695                 700                 


Glu Tyr Leu Leu Met Lys Trp Leu Ala Tyr Gly Phe Arg Ala His Met 
705                 710                 715                 720 


Met Asn Leu Gly Ser Tyr Cys Leu Gly Leu Ile Pro Met Thr Ile Leu 
                725                 730                 735     


Val Val Asn Ile Lys Pro Gly Met Ala Phe Asn Ser Thr Gly Ile Ile 
            740                 745                 750         


Asn Glu Thr Ser Asp His Ser Glu Ile Leu Asp Thr Thr Asn Ser Tyr 
        755                 760                 765             


Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser Ser Ile Phe Gly 
    770                 775                 780                 


Tyr Cys Lys Glu Ala Gly Gln Ile Phe Gln Gln Lys Arg Asn Tyr Phe 
785                 790                 795                 800 


Met Asp Ile Ser Asn Val Leu Glu Trp Ile Ile Tyr Thr Thr Gly Ile 
                805                 810                 815     


Ile Phe Val Leu Pro Leu Phe Val Glu Ile Pro Ala His Leu Gln Trp 
            820                 825                 830         


Gln Cys Gly Ala Ile Ala Val Tyr Phe Tyr Trp Met Asn Phe Leu Leu 
        835                 840                 845             


Tyr Leu Gln Arg Phe Glu Asn Cys Gly Ile Phe Ile Val Met Leu Glu 
    850                 855                 860                 


Val Ile Leu Lys Thr Leu Leu Arg Ser Thr Val Val Phe Ile Phe Leu 
865                 870                 875                 880 


Leu Leu Ala Phe Gly Leu Ser Phe Tyr Ile Leu Leu Asn Leu Gln Asp 
                885                 890                 895     


Pro Phe Ser Ser Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met 
            900                 905                 910         


Leu Gly Asp Ile Asn Tyr Arg Glu Ser Phe Leu Glu Pro Tyr Leu Arg 
        915                 920                 925             


Asn Glu Leu Ala His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe 
    930                 935                 940                 


Thr Ile Phe Val Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala 
945                 950                 955                 960 


Val Gly Asp Ile Ala Glu Val Gln Lys His Ala Ser Leu Lys Arg Ile 
                965                 970                 975     


Ala Met Gln Val Glu Leu His Thr Ser Leu Glu Lys Lys Leu Pro Leu 
            980                 985                 990         


Trp Phe Leu Arg Lys Val Asp Gln  Lys Ser Thr Ile Val  Tyr Pro Asn 
        995                 1000                 1005             


Lys Pro  Arg Ser Gly Gly Met  Leu Phe His Ile Phe  Cys Phe Leu 
    1010                 1015                 1020             


Phe Cys  Thr Gly Glu Ile Arg  Gln Glu Ile Pro Asn  Ala Asp Lys 
    1025                 1030                 1035             


Ser Leu  Glu Met Glu Ile Leu  Lys Gln Lys Tyr Arg  Leu Lys Asp 
    1040                 1045                 1050             


Leu Thr  Phe Leu Leu Glu Lys  Gln His Glu Leu Ile  Lys Leu Ile 
    1055                 1060                 1065             


Ile Gln  Lys Met Glu Ile Ile  Ser Glu Thr Glu Asp  Asp Asp Ser 
    1070                 1075                 1080             


His Cys  Ser Phe Gln Asp Arg  Phe Lys Lys Glu Gln  Met Glu Gln 
    1085                 1090                 1095             


Arg Phe  Cys Tyr Glu Asn Glu  
    1100                 1105 


<210> 7
<211> 1096
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val Pro Asp Asp Thr Glu Asp Phe 
            20                  25                  30          


Lys Glu Ser Leu Lys Val Val Phe Glu Gly Ser Ala Tyr Gly Leu Gln 
        35                  40                  45              


Asn Phe Asn Lys Gln Lys Lys Leu Lys Arg Cys Asp Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Asp Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn 
65                  70                  75                  80  


Gln Ile Glu Ser Val Lys Phe Leu Leu Ser Arg Gly Ala Asn Pro Asn 
                85                  90                  95      


Leu Arg Asn Phe Asn Met Met Ala Pro Leu His Ile Ala Val Gln Gly 
            100                 105                 110         


Met Asn Asn Glu Val Met Lys Val Leu Leu Glu His Arg Thr Ile Asp 
        115                 120                 125             


Val Asn Leu Glu Gly Glu Asn Gly Asn Thr Ala Val Ile Ile Ala Cys 
    130                 135                 140                 


Thr Thr Asn Asn Ser Glu Ala Leu Gln Ile Leu Leu Lys Lys Gly Ala 
145                 150                 155                 160 


Lys Pro Cys Lys Ser Asn Lys Trp Gly Cys Phe Pro Ile His Gln Ala 
                165                 170                 175     


Ala Phe Ser Gly Ser Lys Glu Cys Met Glu Ile Ile Leu Arg Phe Gly 
            180                 185                 190         


Glu Glu His Gly Tyr Ser Arg Gln Leu His Ile Asn Phe Met Asn Asn 
        195                 200                 205             


Gly Lys Ala Thr Pro Leu His Leu Ala Val Gln Asn Gly Asp Leu Glu 
    210                 215                 220                 


Met Ile Lys Met Cys Leu Asp Asn Gly Ala Gln Ile Asp Pro Val Glu 
225                 230                 235                 240 


Lys Gly Arg Cys Thr Ala Ile His Phe Ala Ala Thr Gln Gly Ala Thr 
                245                 250                 255     


Glu Ile Val Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile 
            260                 265                 270         


Val Asn Thr Thr Asp Gly Cys His Glu Thr Met Leu His Arg Ala Ser 
        275                 280                 285             


Leu Phe Asp His His Glu Leu Ala Asp Tyr Leu Ile Ser Val Gly Ala 
    290                 295                 300                 


Asp Ile Asn Lys Ile Asp Ser Glu Gly Arg Ser Pro Leu Ile Leu Ala 
305                 310                 315                 320 


Thr Ala Ser Ala Ser Trp Asn Ile Val Asn Leu Leu Leu Ser Lys Gly 
                325                 330                 335     


Ala Gln Val Asp Ile Lys Asp Asn Phe Gly Arg Asn Phe Leu His Leu 
            340                 345                 350         


Thr Val Gln Gln Pro Tyr Gly Leu Lys Asn Leu Arg Pro Glu Phe Met 
        355                 360                 365             


Gln Met Gln Gln Ile Lys Glu Leu Val Met Asp Glu Asp Asn Asp Gly 
    370                 375                 380                 


Cys Thr Pro Leu His Tyr Ala Cys Arg Gln Gly Gly Pro Gly Ser Val 
385                 390                 395                 400 


Asn Asn Leu Leu Gly Phe Asn Val Ser Ile His Ser Lys Ser Lys Asp 
                405                 410                 415     


Lys Lys Ser Pro Leu His Phe Ala Ala Ser Tyr Gly Arg Ile Asn Thr 
            420                 425                 430         


Cys Gln Arg Leu Leu Gln Asp Ile Ser Asp Thr Arg Leu Leu Asn Glu 
        435                 440                 445             


Gly Asp Leu His Gly Met Thr Pro Leu His Leu Ala Ala Lys Asn Gly 
    450                 455                 460                 


His Asp Lys Val Val Gln Leu Leu Leu Lys Lys Gly Ala Leu Phe Leu 
465                 470                 475                 480 


Ser Asp His Asn Gly Trp Thr Ala Leu His His Ala Ser Met Gly Gly 
                485                 490                 495     


Tyr Thr Gln Thr Met Lys Val Ile Leu Asp Thr Asn Leu Lys Cys Thr 
            500                 505                 510         


Asp Arg Leu Asp Glu Asp Gly Asn Thr Ala Leu His Phe Ala Ala Arg 
        515                 520                 525             


Glu Gly His Ala Lys Ala Val Ala Leu Leu Leu Ser His Asn Ala Asp 
    530                 535                 540                 


Ile Val Leu Asn Lys Gln Gln Ala Ser Phe Leu His Leu Ala Leu His 
545                 550                 555                 560 


Asn Lys Arg Lys Glu Val Val Leu Thr Ile Ile Arg Ser Lys Arg Trp 
                565                 570                 575     


Asp Glu Cys Leu Lys Ile Phe Ser His Asn Ser Pro Gly Asn Lys Cys 
            580                 585                 590         


Pro Ile Thr Glu Met Ile Glu Tyr Leu Pro Glu Cys Met Lys Val Leu 
        595                 600                 605             


Leu Asp Phe Cys Met Leu His Ser Thr Glu Asp Lys Ser Cys Arg Asp 
    610                 615                 620                 


Tyr Tyr Ile Glu Tyr Asn Phe Lys Tyr Leu Gln Cys Pro Leu Glu Phe 
625                 630                 635                 640 


Thr Lys Lys Thr Pro Thr Gln Asp Val Ile Tyr Glu Pro Leu Thr Ala 
                645                 650                 655     


Leu Asn Ala Met Val Gln Asn Asn Arg Ile Glu Leu Leu Asn His Pro 
            660                 665                 670         


Val Cys Lys Glu Tyr Leu Leu Met Lys Trp Leu Ala Tyr Gly Phe Arg 
        675                 680                 685             


Ala His Met Met Asn Leu Gly Ser Tyr Cys Leu Gly Leu Ile Pro Met 
    690                 695                 700                 


Thr Ile Leu Val Val Asn Ile Lys Pro Gly Met Ala Phe Asn Ser Thr 
705                 710                 715                 720 


Gly Ile Ile Asn Glu Thr Ser Asp His Ser Glu Ile Leu Asp Thr Thr 
                725                 730                 735     


Asn Ser Tyr Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser Ser 
            740                 745                 750         


Ile Phe Gly Tyr Cys Lys Glu Ala Gly Gln Ile Phe Gln Gln Lys Arg 
        755                 760                 765             


Asn Tyr Phe Met Asp Ile Ser Asn Val Leu Glu Trp Ile Ile Tyr Thr 
    770                 775                 780                 


Thr Gly Ile Ile Phe Val Leu Pro Leu Phe Val Glu Ile Pro Ala His 
785                 790                 795                 800 


Leu Gln Trp Gln Cys Gly Ala Ile Ala Val Tyr Phe Tyr Trp Met Asn 
                805                 810                 815     


Phe Leu Leu Tyr Leu Gln Arg Phe Glu Asn Cys Gly Ile Phe Ile Val 
            820                 825                 830         


Met Leu Glu Val Ile Leu Lys Thr Leu Leu Arg Ser Thr Val Val Phe 
        835                 840                 845             


Ile Phe Leu Leu Leu Ala Phe Gly Leu Ser Phe Tyr Ile Leu Leu Asn 
    850                 855                 860                 


Leu Gln Asp Pro Phe Ser Ser Pro Leu Leu Ser Ile Ile Gln Thr Phe 
865                 870                 875                 880 


Ser Met Met Leu Gly Asp Ile Asn Tyr Arg Glu Ser Phe Leu Glu Pro 
                885                 890                 895     


Tyr Leu Arg Asn Glu Leu Ala His Pro Val Leu Ser Phe Ala Gln Leu 
            900                 905                 910         


Val Ser Phe Thr Ile Phe Val Pro Ile Val Leu Met Asn Leu Leu Ile 
        915                 920                 925             


Gly Leu Ala Val Gly Asp Ile Ala Glu Val Gln Lys His Ala Ser Leu 
    930                 935                 940                 


Lys Arg Ile Ala Met Gln Val Glu Leu His Thr Ser Leu Glu Lys Lys 
945                 950                 955                 960 


Leu Pro Leu Trp Phe Leu Arg Lys Val Asp Gln Lys Ser Thr Ile Val 
                965                 970                 975     


Tyr Pro Asn Lys Pro Arg Ser Gly Gly Met Leu Phe His Ile Phe Cys 
            980                 985                 990         


Phe Leu Phe Cys Thr Gly Glu Ile  Arg Gln Glu Ile Pro  Asn Ala Asp 
        995                 1000                 1005             


Lys Ser  Leu Glu Met Glu Ile  Leu Lys Gln Lys Tyr  Arg Leu Lys 
    1010                 1015                 1020             


Asp Leu  Thr Phe Leu Leu Glu  Lys Gln His Glu Leu  Ile Lys Leu 
    1025                 1030                 1035             


Ile Ile  Gln Lys Met Glu Ile  Ile Ser Glu Thr Glu  Asp Asp Asp 
    1040                 1045                 1050             


Ser His  Cys Ser Phe Gln Asp  Arg Phe Lys Lys Glu  Gln Met Glu 
    1055                 1060                 1065             


Gln Arg  Asn Ser Arg Trp Asn  Thr Val Leu Arg Ala  Val Lys Ala 
    1070                 1075                 1080             


Lys Thr  His His Leu Glu Pro  Phe Cys Tyr Glu Asn  Glu 
    1085                 1090                 1095     


<210> 8
<211> 137
<212> DNA
<213> Mus musculus

<400> 8
gtgattttta aaacattgct gagatcgacc ggagtgttta tcttcctcct actggctttt       60

ggcctcagct tttatgttct cctgaatttc caagatgcct tcagcacccc attgctttcc      120

ttaatccaga cattcag                                                     137


<210> 9
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> K or R

<220>
<221> MOD_RES
<222> (12)..(12)
<223> G, E, or A

<400> 9
Met Lys Arg Ser Leu Arg Xaa Met Leu Arg Pro Xaa Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Gln Gly Val 
            20                  25  


<210> 10
<211> 25
<212> PRT
<213> Homo sapiens

<400> 10
Met Lys Arg Ser Leu Arg Lys Met Trp Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Glu Asp Val 
            20                  25  


<210> 11
<211> 25
<212> PRT
<213> Mus sp.

<400> 11
Met Lys Arg Gly Leu Arg Arg Ile Leu Leu Pro Glu Glu Arg Lys Glu 
1               5                   10                  15      


Val Gln Gly Val Val Tyr Arg Gly Val 
            20                  25  


<210> 12
<211> 25
<212> PRT
<213> Castor sp.

<400> 12
Met Lys Arg Ser Leu Arg Lys Met Leu Arg Pro Ala Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Asn Tyr Gln Gly Val 
            20                  25  


<210> 13
<211> 25
<212> PRT
<213> Vicugna sp.

<400> 13
Met Lys Arg Ser Leu Arg Lys Met Leu Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Gln Gly Val 
            20                  25  


<210> 14
<211> 25
<212> PRT
<213> Equus sp.

<400> 14
Met Lys Arg Ser Leu Arg Lys Met Leu Arg Pro Gly Glu Lys Lys Glu 
1               5                   10                  15      


Pro Pro Gly Val Val Tyr Gln Gly Val 
            20                  25  


<210> 15
<211> 25
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Bat sequence

<400> 15
Met Arg Arg Ser Leu Lys Arg Met Leu Arg Thr Ala Gly Lys Lys Glu 
1               5                   10                  15      


Pro Gln Gly Val Val Tyr Gln Gly Val 
            20                  25  


<210> 16
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> K, R, N, or Q

<220>
<221> MOD_RES
<222> (3)..(3)
<223> R or F

<220>
<221> MOD_RES
<222> (4)..(4)
<223> S or absent

<220>
<221> MOD_RES
<222> (5)..(5)
<223> L, I, or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R, L, or absent

<220>
<221> MOD_RES
<222> (7)..(7)
<223> K or absent

<220>
<221> MOD_RES
<222> (8)..(8)
<223> M, L, W, or absent

<220>
<221> MOD_RES
<222> (9)..(9)
<223> W, F, or absent

<220>
<221> MOD_RES
<222> (10)..(10)
<223> R, Q, or absent

<220>
<221> MOD_RES
<222> (11)..(11)
<223> E, G, or S

<220>
<221> MOD_RES
<222> (13)..(13)
<223> K, E, or D

<220>
<221> MOD_RES
<222> (14)..(14)
<223> E, K, V, or L

<220>
<221> MOD_RES
<222> (15)..(15)
<223> P, A, K, or V

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Q, A, or R

<220>
<221> MOD_RES
<222> (17)..(17)
<223> G, D, S, Q, or R

<220>
<221> MOD_RES
<222> (18)..(18)
<223> P, T, N, or absent

<220>
<221> MOD_RES
<222> (19)..(19)
<223> V, D, T, or S

<220>
<221> MOD_RES
<222> (20)..(20)
<223> V, T, S, C, or F

<220>
<221> MOD_RES
<222> (22)..(22)
<223> E, H, T, or K

<220>
<221> MOD_RES
<222> (23)..(23)
<223> D, G, Y, or C

<400> 16
Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Tyr Xaa Xaa Val 
            20                  


<210> 17
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Alligator sequence

<400> 17
Met Arg Arg Ser Leu Leu Lys Leu Phe Gln Gly Arg Glu Lys Ala Ala 
1               5                   10                  15      


Asp Pro Asp Thr Tyr His Gly Val 
            20                  


<210> 18
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Snake sequence

<400> 18
Met Lys Arg Ser Ile Leu Lys Trp Phe Gln Ser Arg Asp Glu Lys Gln 
1               5                   10                  15      


Ser Thr Ser Tyr Glu Gly Val 
            20              


<210> 19
<211> 17
<212> PRT
<213> Poecilia sp.

<400> 19
Met Asn Phe Ser Arg Asp Val Ala Arg Gln Thr Ser Cys Tyr Thr Tyr 
1               5                   10                  15      


Val 
    


<210> 20
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Zebrafish sequence

<400> 20
Met Gln Phe Gly Lys Glu Leu Val Arg Arg Asn Ser Phe Tyr Lys Cys 
1               5                   10                  15      


Val 
    


<210> 21
<211> 25
<212> PRT
<213> Homo sapiens

<400> 21
Thr Asn Ser Tyr Leu Ile Lys Thr Cys Met Ile Leu Val Phe Leu Ser 
1               5                   10                  15      


Ser Ile Phe Gly Tyr Cys Lys Glu Ala 
            20                  25  


<210> 22
<211> 25
<212> PRT
<213> Mus sp.

<400> 22
Leu Asn Ser Phe Pro Ile Lys Ile Cys Met Ile Leu Val Phe Leu Ser 
1               5                   10                  15      


Ser Ile Phe Gly Tyr Cys Lys Glu Val 
            20                  25  


<210> 23
<211> 25
<212> PRT
<213> Castor sp.

<400> 23
Thr Asn Ser Tyr Pro Ile Lys Val Cys Met Val Leu Val Phe Leu Ser 
1               5                   10                  15      


Ser Ile Phe Gly Tyr Cys Lys Glu Val 
            20                  25  


<210> 24
<211> 25
<212> PRT
<213> Vicugna sp.

<400> 24
Lys Asn Ser Tyr Thr Ile Lys Val Cys Met Ile Leu Val Leu Leu Ser 
1               5                   10                  15      


Ser Ile Phe Gly Tyr Cys Lys Glu Val 
            20                  25  


<210> 25
<211> 25
<212> PRT
<213> Equus sp.

<400> 25
Lys Asn Ser Tyr Ser Ile Lys Val Cys Met Ile Leu Val Phe Leu Ser 
1               5                   10                  15      


Ser Ile Phe Gly Tyr Cys Lys Glu Val 
            20                  25  


<210> 26
<211> 25
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Bat sequence

<400> 26
Lys Asp Ser Tyr Ser Ile Lys Val Cys Met Ile Leu Val Phe Leu Ser 
1               5                   10                  15      


Ser Leu Phe Gly Tyr Cys Lys Glu Leu 
            20                  25  


<210> 27
<211> 25
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Alligator sequence

<400> 27
Glu Glu Ser Tyr Phe Ile Arg Val Cys Met Cys Leu Val Leu Ile Met 
1               5                   10                  15      


Ser Leu Leu Gly Ile Cys Lys Glu Ile 
            20                  25  


<210> 28
<211> 25
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Snake sequence

<400> 28
Lys Asp Ser Asn Phe Ile Lys Val Cys Met Ser Leu Val Phe Ile Met 
1               5                   10                  15      


Ser Leu Phe Gly Ile Cys Lys Glu Ile 
            20                  25  


<210> 29
<211> 25
<212> PRT
<213> Poecilia sp.

<400> 29
Glu Gln Ser Met Phe Leu Ser Phe Cys Met Val Met Val Leu Ile Thr 
1               5                   10                  15      


Asn Val Tyr Ser Ile Gly Lys Glu Val 
            20                  25  


<210> 30
<211> 25
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Zebrafish sequence

<400> 30
Glu Gln Gln Tyr Leu Ile Ser Val Cys Ile Ile Met Val Ile Val Met 
1               5                   10                  15      


Asn Val Tyr Ser Ile Cys Lys Glu Val 
            20                  25  


<210> 31
<211> 31
<212> PRT
<213> Homo sapiens

<400> 31
Met Asp Thr Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu 
1               5                   10                  15      


Leu Met Glu Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His 
            20                  25                  30      


<210> 32
<211> 6
<212> PRT
<213> Mus sp.

<400> 32
Ala Ala Ala Glu Gly Gln 
1               5       


<210> 33
<211> 4
<212> PRT
<213> Mus sp.

<400> 33
Glu Leu Met Glu 
1               


<210> 34
<211> 6
<212> PRT
<213> Castor sp.

<400> 34
Ala Ala Ala Glu Gly Gln 
1               5       


<210> 35
<211> 4
<212> PRT
<213> Vicugna sp.

<400> 35
Glu Leu Met Glu 
1               


<210> 36
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Bat sequence

<400> 36
Leu His Tyr Ala Ala 
1               5   


<210> 37
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Alligator sequence

<400> 37
Gly Gln Ile Glu Leu Met 
1               5       


<210> 38
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Zebrafish sequence

<400> 38
Leu His Tyr Ala 
1               


<210> 39
<211> 159
<212> PRT
<213> Homo sapiens

<400> 39
Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met Leu Gly Asp Ile 
1               5                   10                  15      


Asn Tyr Arg Glu Ser Phe Leu Glu Pro Tyr Leu Arg Asn Glu Leu Ala 
            20                  25                  30          


His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe Thr Ile Phe Val 
        35                  40                  45              


Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Leu His Tyr Ala Ala Ala Glu Gly Gln Ile Glu Leu Met Glu 
65                  70                  75                  80  


Lys Ile Thr Arg Asp Ser Ser Leu Glu Val Leu His Glu Met Asp Asp 
                85                  90                  95      


Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn Gln Ile Glu 
            100                 105                 110         


Ser Val Lys Phe Leu Leu Ser Arg Asp Asp Ser His Cys Ser Phe Gln 
        115                 120                 125             


Asp Arg Phe Lys Lys Glu Gln Met Glu Gln Arg Asn Ser Arg Trp Asn 
    130                 135                 140                 


Thr Val Leu Arg Ala Val Lys Ala Lys Thr His His Leu Glu Pro 
145                 150                 155                 


<210> 40
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Pro Leu Leu Ser Ile Ile Gln Thr Phe Ser Met Met Leu Gly Asp Ile 
1               5                   10                  15      


Asn Tyr Arg Glu Ser Phe Leu His Pro Tyr Leu Arg Asn Glu Leu Ala 
            20                  25                  30          


His Pro Val Leu Ser Phe Ala Gln Leu Val Ser Phe Thr Ile Phe Val 
        35                  40                  45              


Pro Ile Val Leu Met Asn Leu Leu Ile Gly Leu Ala Asp Met Asp Thr 
    50                  55                  60                  


Phe Phe Asp Tyr Gly Asn Thr Pro Leu His Cys Ala Val Glu Lys Asn 
65                  70                  75                  80  


Gln Ile Glu Ser Val Lys Phe Leu Leu Ser Arg Asp Asp Ser His Cys 
                85                  90                  95      


Ser Phe Gln Asp Arg Phe Lys Lys Glu Gln Met Glu Gln Arg Phe Cys 
            100                 105                 110         


Tyr Glu Asn Glu 
        115     


