                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> NOVEL ANTI-PD1 ANTIBODIES FOR INHIBITING T-CELL ACTIVITY

<130> 701039-097810WOPT

<140> PCT/US2021/041407
<141> 2021-07-13

<150> 63/124,270
<151> 2020-12-11

<150> 62/705,726
<151> 2020-07-13

<160> 132   

<170> PatentIn version 3.5

<210> 1
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Gln Gly His Leu Val Glu Ser Gly Gly Asp Val Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Glu Ser Gly Val Asp Leu Ser Asp Phe 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Lys Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Glu Met Ile Ser Leu Arg Val Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Arg Arg Gly Pro Trp Phe Thr Tyr Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Thr 
        115                 


<210> 2
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Glu Ile Val Leu Thr Gln Ser Pro Val Ile Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asp 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Val Asp Leu Ser Asp Phe Gly 
1               5               


<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Ile Trp Tyr Asp Gly Ser Lys Lys 
1               5               


<210> 5
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ala Arg Gly Ile Arg Arg Gly Pro Trp Phe Thr Tyr 
1               5                   10          


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gln Ser Ile Ser Ser Asp 
1               5       


<210> 7
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Asp Ala Ser 
1           


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210> 9
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gln Leu Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Val Phe Ser Asp Phe 
            20                  25                  30          


Gly Leu Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Arg Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys His Ser Lys Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Glu Ile Glu Val Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asp Thr Asp 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Arg Pro Gly Gln Thr Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Thr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Val Val Phe Ser Asp Phe Gly 
1               5               


<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ile Trp Tyr Asp Gly Ser Arg Lys 
1               5               


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Ala Arg Cys His Ser Lys Glu Asp Tyr 
1               5                   


<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Gln Ser Ile Asp Thr Asp 
1               5       


<210> 15
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Asp Ala Ser 
1           


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gln Gln Arg Thr Thr Trp Pro Leu Thr 
1               5                   


<210> 17
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ala Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Arg Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys His Ser Lys Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 18
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Glu Ile Val Leu Thr Gln Phe Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Asn Ile Asp Ser Asp 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Thr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Val Ala Phe Ser Asp Tyr Gly 
1               5               


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Val Ile Trp Tyr Asp Gly Ser Arg Lys His 
1               5                   10  


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Ala Arg Cys His Ser Lys Asp Asp Tyr 
1               5                   


<210> 22
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Gln Asn Ile Asp Ser Asp 
1               5       


<210> 23
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Asp Ala Ser 
1           


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gln Gln Arg Thr Thr Trp Pro Leu Thr 
1               5                   


<210> 25
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Val Thr Phe Gly Asp Phe 
            20                  25                  30          


Gly Phe Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Arg Lys His Tyr Ala Glu Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Met Met Tyr 
65                  70                  75                  80  


Leu Glu Met Thr Gly Leu Arg Val Glu Asp Thr Ala Lys Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser His Ser His Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 26
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


His Asp Ala Phe Lys Arg Ala Ala Gly Ile Pro Thr Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asp Asn Trp Pro Leu 
                85                  90                  95      


Asn Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gly Val Thr Phe Gly Asp Phe Gly 
1               5               


<210> 28
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Ile Trp Tyr Asp Gly Ser Arg Lys 
1               5               


<210> 29
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Thr Arg Ser His Ser His Glu Asp Tyr 
1               5                   


<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Gln Ser Ile Ser Asn Tyr 
1               5       


<210> 31
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Asp Ala Phe 
1           


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Gln Gln Arg Asp Asn Trp Pro Leu Asn 
1               5                   


<210> 33
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Val Phe Ser Asp Tyr 
            20                  25                  30          


Gly Leu Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Lys Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Asp Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Gly Ile Arg Gln Gly Pro Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Arg Val Thr Val Ser Pro 
        115                 


<210> 34
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asp 
            20                  25                  30          


Leu Thr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Val Val Tyr Tyr Cys Leu Gln Arg Ser Asp Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Gly Val Val Phe Ser Asp Tyr Gly 
1               5               


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Ile Trp Tyr Asp Gly Ser Lys Lys 
1               5               


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Ser Arg Gly Ile Arg Gln Gly Pro Trp Phe Ala Tyr 
1               5                   10          


<210> 38
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Gln Ser Ile Ser Ser Asp 
1               5       


<210> 39
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Asp Ala Ser 
1           


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Leu Gln Arg Ser Asp Trp Pro Leu Thr 
1               5                   


<210> 41
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ala Val Phe Arg Asp Leu 
            20                  25                  30          


Gly Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Gly Arg Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Met Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Val Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser His Ser Thr Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 42
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asp 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


His Gly Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asp Ser Trp Pro Leu 
                85                  90                  95      


Asn Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Ala Val Phe Arg Asp Leu Gly 
1               5               


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Ile Trp Tyr Asp Gly Gly Arg Lys 
1               5               


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Thr Arg Ser His Ser Thr Asp Asp Tyr 
1               5                   


<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gln Ser Ile Ser Ser Asp 
1               5       


<210> 47
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Gly Ala Ser 
1           


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gln Gln Arg Asp Ser Trp Pro Leu Asn 
1               5                   


<210> 49
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Gln Glu Trp Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Lys Val Thr Phe Asn Asp Phe 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Ser Arg Asn His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Leu Ser Arg Asp Asn Ser Lys Asn Met Val His 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Arg Thr Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile His Ser Asn Asp Asp Tyr Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 50
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Phe Ile 
        35                  40                  45              


Phe Asp Ala Ser Lys Arg Val Asn Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asp Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Ser Arg Val Glu Ile Lys 
            100                 105         


<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Lys Val Thr Phe Asn Asp Phe Gly 
1               5               


<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Ile Trp Tyr Asp Gly Ser Arg Asn 
1               5               


<210> 53
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Ala Arg Gly Ile His Ser Asn Asp Asp Tyr 
1               5                   10  


<210> 54
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Gln Ser Val Ser Ser Asp 
1               5       


<210> 55
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Asp Ala Ser 
1           


<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Gln Gln Arg Thr Asp Trp Pro Leu Thr 
1               5                   


<210> 57
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Val Val Phe Ser Asp Tyr 
            20                  25                  30          


Gly Phe Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Arg Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Arg Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Gly Leu Arg Val Glu Asp Thr Ala Lys Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser His Ser His Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 58
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Asn Ile Asp Asn Ser 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asp His Trp Pro Leu 
                85                  90                  95      


Asn Phe Gly Gly Gly Thr Lys Val Glu Val Lys 
            100                 105         


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Gly Val Val Phe Ser Asp Tyr Gly 
1               5               


<210> 60
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Ile Trp Tyr Asp Gly Ser Arg Lys 
1               5               


<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Thr Arg Ser His Ser His Glu Asp Tyr 
1               5                   


<210> 62
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Gln Asn Ile Asp Asn Ser 
1               5       


<210> 63
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Asp Ala Ser 
1           


<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Gln Gln Arg Asp His Trp Pro Leu Asn 
1               5                   


<210> 65
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Val Ile Ser Asp Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ser Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Leu Ile Gly Ala Thr Arg Arg Gly Asn Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210> 66
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Glu Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asp Ser Asp 
            20                  25                  30          


Leu Ala Trp Ser Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 
            100                 105         


<210> 67
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Gly Leu Val Ile Ser Asp Tyr Gly 
1               5               


<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Ile Trp Tyr Asp Gly Ser Lys Lys 
1               5               


<210> 69
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Ala Arg Phe Leu Ile Gly Ala Thr Arg Arg Gly Asn Ala Met Asp Tyr 
1               5                   10                  15      


<210> 70
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Gln Ser Ile Asp Ser Asp 
1               5       


<210> 71
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Asp Ala Ser 
1           


<210> 72
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Gln Gln Arg Ser Asp Trp Pro Leu Thr 
1               5                   


<210> 73
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Val Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Leu Ile Gly Ala Thr Arg Arg Gly Asn Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Ile Val Ser Ser 
        115                 120             


<210> 74
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Glu Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asp Ser Asp 
            20                  25                  30          


Leu Ala Trp Ser Gln Gln Lys Thr Gly Gln Pro Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 
            100                 105         


<210> 75
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Gly Leu Val Phe Arg Asp Tyr Gly 
1               5               


<210> 76
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Ile Trp Tyr Asp Gly Thr Lys Lys 
1               5               


<210> 77
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Ala Arg Phe Leu Ile Gly Ala Thr Arg Arg Gly Asn Ala Met Asp Tyr 
1               5                   10                  15      


<210> 78
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
Gln Ser Ile Asp Ser Asp 
1               5       


<210> 79
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Asp Ala Ser 
1           


<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Gln Gln Arg Ser Asp Trp Pro Leu Thr 
1               5                   


<210> 81
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ala Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Gly Leu Lys Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210> 82
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Ser 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Asn Pro Gly Gln Ser Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Thr Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Asp Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 83
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Gly Val Ala Phe Arg Asp Tyr Gly 
1               5               


<210> 84
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr 
1               5                   10  


<210> 85
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Ala Arg Asn Asp Asp Tyr 
1               5       


<210> 86
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Gln Ser Val Ser Asn Ser 
1               5       


<210> 87
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 87
Asp Thr Ser 
1           


<210> 88
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
His Gln Arg Ser Asp Trp Pro Leu Thr 
1               5                   


<210> 89
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Leu Ile Trp Tyr Asp Gly Ser Lys Lys Phe 
1               5                   10  


<210> 90
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Val Ile Trp Tyr Asp Gly Ser Arg Lys His 
1               5                   10  


<210> 91
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Val Ile Trp Tyr Asp Gly Ser Arg Lys His 
1               5                   10  


<210> 92
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Leu Ile Trp Tyr Asp Gly Ser Lys Lys Phe 
1               5                   10  


<210> 93
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Val Ile Trp Tyr Asp Gly Gly Arg Lys His 
1               5                   10  


<210> 94
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 94
Ile Ile Trp Tyr Asp Gly Ser Arg Asn His 
1               5                   10  


<210> 95
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 95
Val Ile Trp Tyr Asp Gly Ser Arg Lys His 
1               5                   10  


<210> 96
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 96
Leu Ile Trp Tyr Asp Gly Ser Lys Lys Tyr 
1               5                   10  


<210> 97
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 97
Leu Ile Trp Tyr Asp Gly Thr Lys Lys Tyr 
1               5                   10  


<210> 98
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 98
Gly Gly Gly Gly Ser 
1               5   


<210> 99
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 99
His His His His His His 
1               5       


<210> 100
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 100
Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro 
1               5                   10  


<210> 101
<211> 340
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 101
caggtgcagt tggtggagtc tgggggagac gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggagt cgccttcagg gactatggca tgcactgggt ccgccaggca      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa gaaatattat      180

ggagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa catgttgtat      240

ctggaaatga acggcctgaa agccgaggac acggcaatgt attattgtgc gaggaacgat      300

gactactggg gccagggaac cctggtcacc gtctcctcag                            340


<210> 102
<211> 349
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 102
caggtgcagc tggtggagtc tgggggagac gtggtccagc cgggggggtc cctgagactc       60

tcctgtgcgg cgtctggagt cgccttcagt gactatggca tggaatgggt ccgccaggct      120

ccaggcaagg ggctggagtg gctggcagtt atctggtatg atggaagtag gaaacactat      180

gcagactccg tgaagggccg attcaccatc tcccgcgaca attccaagaa cattctgtat      240

ctacaaatga acagcctgag agccgaggac acggctatgt attactgtgc gagatgccac      300

tctaaagatg actactgggg ccagggaacc ctggtcaccg tctcctcag                  349


<210> 103
<211> 352
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 103
caggagtggt tggtggagtc ggggggagac gtggtccagc cgggggggtc cctgagactc       60

tcctgtgcga cgtctaaagt caccttcaat gactttggca ttcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcaatt atttggtatg atggaagcag gaatcactac      180

gcagactccg tgaggggccg attcaccctc tccagggaca attccaaaaa catggtccat      240

cttcacatga gtagcctgag aaccgaggac acggctatgt attattgtgc gcgaggaata      300

cactctaacg atgactattg gggccaggga accatggtca ccgtctcctc ag              352


<210> 104
<211> 349
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 104
caggttcagc tggtggaatc tgggggagac gtggtccagc cgggggggtc cctgagactc       60

tcctgtgcag tgtctggagt caccttcggt gactttggct tcgaatgggt ccgccaggct      120

ccaggcaagg gtctggagtg ggtggcagtt atttggtacg acggaagcag aaaacattat      180

gcagagtccg tgaggggccg atttaccatc tccagagaca attccaggaa catgatgtat      240

ctggaaatga ctggactgag agtcgaggac acggctaaat attactgtac gagaagtcac      300

tctcacgagg actactgggg ccagggaacc ctggtcaccg tctcctcag                  349


<210> 105
<211> 349
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 105
caggtgcagc tggtggagtc tgggggagac gtggtccagc ctggggggtc cctgagactc       60

tcctgtacag tgtctggagc cgtcttccgt gacttgggca tggaatgggt ccgtcaggcc      120

ccaggcaagg ggctggaatg gttggcagtt atatggtacg acggaggtag aaaacactat      180

gcggactccg tgaagggccg gttcaccatc tccagagaca attccaggaa catgctcttt      240

ctgcaaatga atggactgag agtcgacgac acggctatgt attactgtac gagaagccac      300

tctaccgatg attactgggg ccagggaacc ctggtcaccg tctcctcag                  349


<210> 106
<211> 349
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 106
caggtgcagt tggtggagtc tgggggagac gtggtccagt cgggggggtc cctgagactc       60

tcctgtgcag tgtctggagt cgtcttcagt gattatggct tcgaatgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtacg acggaagtag gaaacattat      180

gcagactccg tccagggccg attcaccatt tccagagaca atttccggaa catgttgtat      240

ctacaaatga ctggactgag agtcgaggac acggctaaat actattgtac gagaagccac      300

tctcacgagg actactgggg ccagggaacc ctggtcaccg tctcctcag                  349


<210> 107
<211> 349
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 107
caattacaac tggtggagtc tgggggagac gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcgg cgtctggggt cgtcttcagt gactttggcc tggaatgggt ccgccaggct      120

ccaggcaagg ggctggagtg gctggcagtt atctggtatg atggaagtcg gaaacattat      180

gcagactccg tgaagggccg attcaccatc tccagggaca attccaagaa catgctctat      240

ctgcaaatga acagtctgag agtcgaggac acggctatgt actactgtgc gcgatgtcac      300

tctaaagagg actactgggg ccagggaacc cttgtcaccg tctcctcag                  349


<210> 108
<211> 370
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 108
caggtgcagc tggtggagtc tgggggagac gtggtccagc ctggggggtc cctgagactc       60

tcctgttcag cgtctggact cgtattcaga gactatggca tgaactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtcggactt atatggtatg atggaactaa aaaatattat      180

tcagacttcg tgaagggccg attcaccatc tccagagaca attccaagaa catgttgtat      240

ctacaaatga acaacctgag agccgaggac acggctattt attactgtgc gagatttcta      300

ataggtgcga cgaggagggg caatgctatg gactactggg gtcaagggac ctcagtcatc      360

gtctcatcag                                                             370


<210> 109
<211> 370
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 109
caggtgcagt tggtggagtc tgggggagac gtggtccagc ctggggggtc cctgagactc       60

tcctgttcag cgtctgggct cgtaatcagt gactatggca tgaactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtcggactt atatggtatg atggaagtaa aaaatattac      180

tcagacttcg tgaagggccg attcaccatc tccagagaca attccaagaa catattgtat      240

ctacaaatga acaacctgag agccgaggac acggctatgt attactgtgc gagatttcta      300

ataggtgcga cgaggagggg caatgctatg gactattggg gtcaaggaac ctcagtcacc      360

gtctcatcag                                                             370


<210> 110
<211> 358
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 110
caggggcacc tggtggagtc tgggggagac gtggtcctgc ctggggggtc cctgagactc       60

tcctgtacag agtctggtgt cgacctcagt gactttggca tacattgggt ccgccagact      120

ccaggcaagg gtctggagtg ggtggcactt atctggtatg atggaagtaa aaaattttat      180

gctgactccg tgaaggaccg attcaccatt tccagagaca attccaagaa tatggtgtat      240

ctggaaatga tcagcctgag agtcgaggat acggctatgt acttctgtgc gagagggata      300

cgacgggggc cctggttcac ttactggggc ccagggactc tggttacagt ctctacag        358


<210> 111
<211> 370
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 111
caggtgcagt tggtggagtc tgggggagac gtggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cgtctggagt cgccttcagg aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg gcctggagtg ggtggcaatt atatggtatg atggaagtaa taaatattat      180

gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa tatgttgtat      240

cttcaaatga atagcctgag agccgaggac acggctatgt attactgtgc gagactctct      300

ataggtacga cccattactt tgatacggac gactactggg gtcaaggaac ctcagtcacc      360

gtctcctcag                                                             370


<210> 112
<211> 358
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 112
caggtgcaac tggtggagtc tgggggagac gtggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cgtctggagt cgtcttcagt gactatggct tgtattgggt ccgccaggct      120

ccaggcaagg gcctggagtg ggtggccctt atatggtatg atgggagtaa gaaattttat      180

gctgactccg tgaagggccg attctccatc tccagagaca attccaagaa catgttgtat      240

ttacaaatga ataatttgag agccgacgac tcggctattt attattgttc gagagggata      300

cgacaggggc catggtttgc ttactggggc caagggactc gtgtcactgt ctctccag        358


<210> 113
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 113
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc aactccttat cctggtacca acagaaccct      120

ggccagtctc ccaggctcat catctatgat acatccaaga gggccactgg catcccagcc      180

aggttcagtg gcagtggatc tgggacagac ttcactctca ccatcaacaa tctagagact      240

gaagattttg cagtttatta ctgtcaccag cgtagcgact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210> 114
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 114
gaaattgtgt tgacacagtt tccggccacc ctgtctctgt ctcccgggga aagagccacc       60

ctctcctgca ggaccagtca gaatattgac agcgacttag cctggttcca acagaaacct      120

ggccaggctc ccaggctcat catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcggtgggtc tgggacagac ttcactctca ccatcaccag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtaccacct ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210> 115
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 115
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgcc ggaccagtca gagtgttagc agcgacttag cctggttcca acagaaacct      120

ggccaggctc ccaggctctt catatttgat gcatccaaaa gggtcaatgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctggaacct      240

gaagattttg cagtttatta ttgtcagcaa cgtaccgact ggcctctcac tttcggcgga      300

gggtccaggg tggagatcaa ac                                               322


<210> 116
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 116
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgta gggccagtca gagtattagc aactacttag cctggttcca acagaaatct      120

ggccaggctc ccaggctcat catccatgat gcatttaaac gggccgctgg catcccaacc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag tctagagcct      240

gaagattttg cagtttatta ttgtcagcag cgtgacaact ggcctctcaa tttcggcgga      300

gggactaagg tggagatcaa ac                                               322


<210> 117
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 117
gaaattgtgt tgacacagtc gccagccact ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgta gggccagtca gagtattagc agcgacttag cctggttcca acagaaacct      120

ggccaggctc ccaggctcat catccatggt gcatccaaaa gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cggtttatta ctgtcagcag cgtgacagct ggcctctcaa tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210> 118
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 118
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgtg gggccagtca gaatattgac aactccttag cctggttcca acagaaacct      120

ggccaggctc ccaggctcat catctatgat gcatctaaaa gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcac tctagagcct      240

gaagattttg cagtttatta ttgtcagcag cgtgaccatt ggcctctcaa tttcggcgga      300

gggaccaagg tggaagtcaa ac                                               322


<210> 119
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 119
gaaattgaag tgacacagtc tccggccacc ctgtccttgt ctccagggga aagagccacc       60

ctctcctgta gggccagtca gagtattgac accgacttag cctggttcca gcagagacct      120

ggccagactc ccagactcat catctatgat gcatccaaaa gggccactgg catcccagcc      180

aggttcagtg gcggtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttacta ctgtcagcag cgtaccacct ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210> 120
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 120
gaagttgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattgac agcgacttag cctggtccca acagaaaact      120

ggccagcctc ccagactcat catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagtag tctagagcct      240

gaagattttg cagtttatta ttgtcagcaa cgtagcgact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcag ac                                               322


<210> 121
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 121
gaagttgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattgac agcgacttag cctggtccca acagaaacct      120

ggccagcctc ccagactcat catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ttgtcagcaa cgtagcgact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcag ac                                               322


<210> 122
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 122
gaaattgtgt tgacacagtc tccagtcatc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattagc agcgacttgg cctggttcca acagacacct      120

ggccaggctc ccaggctcat catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cggagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210> 123
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 123
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaggtt      120

ggccaggctc ccaggctcat catctttgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcaccag cctagatcct      240

gaagattttg cagtttatta ctgtcagcaa cgtagcgcct ggcctctcac tttcggcgga      300

gggaccaagg tggagatcag ac                                               322


<210> 124
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 124
gaaattgtgc tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagcattagc agcgacttaa cctggttcca acagaaacct      120

ggccaggctc ccaggctcat catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagtag cctcgagcct      240

gaagattttg tagtttatta ctgtctgcaa cgtagcgact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210> 125
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 125
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ala Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210> 126
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 126
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210> 127
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 127
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 128
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 128
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 129
<211> 340
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 129
caggtgcagc tggtggagtc tgggggagac gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggagt cgccttcagt aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa catgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctatgt attactgtgc gaggaacgat      300

gactactggg gccagggaac cctggtcacc gtctcctcag                            340


<210> 130
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 130
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcat catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210> 131
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 131
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ala Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Ile Gly Thr Thr His Tyr Phe Asp Thr Asp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210> 132
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 132
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Val Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


Phe Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Asp Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ala Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 
            100                 105         


