               SEQUENCE LISTING

<110> Sorrentino Pinto

<120> METODI E KIT PER LA D IAGNOSI DEL TUMORE DEL POLMONE BI5513R

<130> BI5513R

<160> 4

<170> BiSSAP 1.3.6

<210> 1
<211> 263
<212> PRT
<213> Homo sapiens


<220> 
<223> Sequenza Amminoacidica della isoforma 4 della proteina umana
      caspasi-4

<400> 1
Met Ala Glu Gly Asn His Arg Lys Lys Pro Leu Lys Val Leu Glu Ser 
1               5                   10                  15      
Leu Gly Lys Asp Phe Leu Thr Gly Val Leu Asp Asn Leu Val Glu Gln 
            20                  25                  30          
Asn Val Leu Asn Trp Lys Glu Glu Glu Lys Lys Lys Tyr Tyr Asp Ala 
        35                  40                  45              
Lys Thr Glu Asp Lys Val Arg Val Met Ala Asp Ser Met Gln Glu Lys 
    50                  55                  60                  
Gln Arg Met Ala Gly Gln Met Leu Leu Gln Thr Phe Phe Asn Ile Asp 
65                  70                  75                  80  
Gln Ile Ser Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro 
                85                  90                  95      
Pro Glu Ser Gly Glu Ser Thr Asp Ala Leu Lys Leu Cys Pro His Glu 
            100                 105                 110         
Glu Phe Leu Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile 
        115                 120                 125             
Lys Glu Arg Asn Asn Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr 
    130                 135                 140                 
Glu Phe Asp His Leu Pro Pro Arg Asn Gly Ala Asp Phe Asp Ile Thr 
145                 150                 155                 160 
Gly Met Lys Glu Leu Leu Glu Gly Leu Asp Tyr Ser Val Asp Val Glu 
                165                 170                 175     
Glu Asn Leu Thr Ala Arg Asp Met Glu Ser Ala Leu Arg Ala Phe Ala 
            180                 185                 190         
Thr Arg Pro Glu His Lys Ser Ser Asp Ser Thr Phe Leu Val Leu Met 
        195                 200                 205             
Ser His Gly Ile Leu Glu Gly Ile Cys Gly Thr Val His Asp Glu Lys 
    210                 215                 220                 
Lys Pro Asp Val Leu Leu Tyr Asp Thr Ile Phe Gln Ile Phe Asn Asn 
225                 230                 235                 240 
Arg Asn Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Val Gln 
                245                 250                 255     
Ala Cys Arg Gly Gly Glu Cys 
            260             

<210> 2
<211> 377
<212> PRT
<213> Homo sapiens


<220> 
<223> Sequenza Amminoacidica della isoforma 1 della proteina umana
      caspasi-4

<400> 2
Met Ala Glu Gly Asn His Arg Lys Lys Pro Leu Lys Val Leu Glu Ser 
1               5                   10                  15      
Leu Gly Lys Asp Phe Leu Thr Gly Val Leu Asp Asn Leu Val Glu Gln 
            20                  25                  30          
Asn Val Leu Asn Trp Lys Glu Glu Glu Lys Lys Lys Tyr Tyr Asp Ala 
        35                  40                  45              
Lys Thr Glu Asp Lys Val Arg Val Met Ala Asp Ser Met Gln Glu Lys 
    50                  55                  60                  
Gln Arg Met Ala Gly Gln Met Leu Leu Gln Thr Phe Phe Asn Ile Asp 
65                  70                  75                  80  
Gln Ile Ser Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro 
                85                  90                  95      
Pro Glu Ser Gly Glu Ser Thr Asp Ala Leu Lys Leu Cys Pro His Glu 
            100                 105                 110         
Glu Phe Leu Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile 
        115                 120                 125             
Lys Glu Arg Asn Asn Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr 
    130                 135                 140                 
Glu Phe Asp His Leu Pro Pro Arg Asn Gly Ala Asp Phe Asp Ile Thr 
145                 150                 155                 160 
Gly Met Lys Glu Leu Leu Glu Gly Leu Asp Tyr Ser Val Asp Val Glu 
                165                 170                 175     
Glu Asn Leu Thr Ala Arg Asp Met Glu Ser Ala Leu Arg Ala Phe Ala 
            180                 185                 190         
Thr Arg Pro Glu His Lys Ser Ser Asp Ser Thr Phe Leu Val Leu Met 
        195                 200                 205             
Ser His Gly Ile Leu Glu Gly Ile Cys Gly Thr Val His Asp Glu Lys 
    210                 215                 220                 
Lys Pro Asp Val Leu Leu Tyr Asp Thr Ile Phe Gln Ile Phe Asn Asn 
225                 230                 235                 240 
Arg Asn Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Val Gln 
                245                 250                 255     
Ala Cys Arg Gly Ala Asn Arg Gly Glu Leu Trp Val Arg Asp Ser Pro 
            260                 265                 270         
Ala Ser Leu Glu Val Ala Ser Ser Gln Ser Ser Glu Asn Leu Glu Glu 
        275                 280                 285             
Asp Ala Val Tyr Lys Thr His Val Glu Lys Asp Phe Ile Ala Phe Cys 
    290                 295                 300                 
Ser Ser Thr Pro His Asn Val Ser Trp Arg Asp Ser Thr Met Gly Ser 
305                 310                 315                 320 
Ile Phe Ile Thr Gln Leu Ile Thr Cys Phe Gln Lys Tyr Ser Trp Cys 
                325                 330                 335     
Cys His Leu Glu Glu Val Phe Arg Lys Val Gln Gln Ser Phe Glu Thr 
            340                 345                 350         
Pro Arg Ala Lys Ala Gln Met Pro Thr Ile Glu Arg Leu Ser Met Thr 
        355                 360                 365             
Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    370                 375         

<210> 3
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> Sequenza Amminoacidica dell’epitopo della sequenza della isoforma
      4 della proteina umana caspasi-4 comprendente il frammento
      252-263 aa.

<400> 3
Val Ile Ile Val Gln Ala Cys Arg Gly Gly Glu Cys 
1               5                   10          

<210> 4
<211> 15
<212> DNA
<213> Homo sapiens


<220> 
<223> Sequenza nucleotidica che differenzia l’isoforma 4 dall’isoforma
      1 della proteina umana caspasi-4

<400> 4
ggtggtgagt gctga                                                     15


