                         SEQUENCE LISTING

<110>  UCL BUSINESS LTD
 
<120>  GENE THERAPY FOR NEUROMUSCULAR AND NEUROMOTOR DISORDERS

<130>  007966286

<140>  PCT/EP2021/069854
<141>  2021-07-15

<150>  GB 2010981.5
<151>  2020-07-16

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaacgagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga acctcttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggttgcctcc ctccgtcccc ggcggacgtg ttcatgattc ctcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca atacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacgtgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgcgggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcatcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta tctatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  2
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacgcaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga acctcttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctaccaaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accatcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccgtgtt accggcagca gcgcgtttct aaaacataaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggcgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  3
<211>  5906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3
atgcccaaca acctgacgga ctgcgaggac ggcgatgggg gagccaaccc gggtgatggc       60

aaccccaagg aaagcagtcc cttcatcaac agcaccgaca cagagaaggg aaaggagtat      120

gatggcaaga acatggcctt gtttgaggag gagatggaca ccagccctat ggtgtcctcc      180

ttgctcagtg gcctggccaa ctacaccaac ctgccccagg gaagtaggga gcatgaagag      240

gcagaaaaca atgagggtgg aaaaaagaag ccggtgcagg ccccacgcat gggcaccttc      300

atgggcgtgt acctgccgtg cctgcagaac atctttggcg tcatcctctt cctgcggctc      360

acctgggtgg tgggcattgc aggcatcatg gagtccttct gcatggtgtt catctgctgc      420

tcctgtacga tgctcacggc catctccatg agtgcaattg caacgaatgg tgttgtgcct      480

gctggtggct cctactacat gatttccagg tctctgggcc cagagtttgg gggtgccgtg      540

ggcctctgct tctacctggg cactaccttt gcaggagcca tgtacatcct gggcaccatc      600

gaaatcctgc tggcttacct cttcccagcc atggccatct tcaaggcaga agatgccagt      660

ggggaggcag cagccatgct gaacaacatg cgtgtttacg gcacctgtgt gctcacctgc      720

atggccactg tggtgtttgt gggtgtcaag tatgtcaaca agtttgccct tgtcttcctg      780

ggttgtgtca tcctctccat cctggccatc tatgctgggg tcatcaagtc tgccttcgac      840

ccacccaact tcccgatctg cctcctgggt aaccgcacgc tgtctcgcca tggctttgat      900

gtctgtgcca agctggcttg ggaaggaaat gagacggtga ccacacggct atggggcctt      960

ttctgctcct ctcgcttcct caacgccacc tgtgatgaat acttcacccg aaacaatgtc     1020

acagagatcc agggcatccc tggtgctgcc agtggcctca tcaaagagaa cctctggagc     1080

tcctacctga ccaagggcgt gattgtggag aggagtggga tgacctcggt gggcctggcc     1140

gatggcactc ctatcgacat ggaccaccct tatgtcttca gtgatatgac ctcctacttc     1200

accctgctgg ttggcatcta cttcccctca gtcacaggga tcatggctgg ttctaaccgc     1260

tctggggacc tgagggatgc ccagaagtca atccccactg gcaccatcct ggccatcgcc     1320

accacctctg ctgtctacat cagctccgtt gttctgtttg gggcctgcat tgagggggtc     1380

gtcctgcggg acaagtttgg cgaagctgtg aatggcaacc tcgtggtggg cactctggcc     1440

tggccatctc catgggtaat tgtcatcgga tccttcttct ccacctgtgg gctgggctgc     1500

agagcctcac gggggcccca cgcctgctgc aggccatctc gagggatggc attgtgccct     1560

tcctgcaggt ctttggccat ggcaaggcca atggagagcc gacctgggcc ctgctcctga     1620

ctgcctgcat ctgcgagatt ggcatcctca ttgcatccct cgacgaggtg gcccccatcc     1680

tctctatgtt cttcctgatg tgctacatgt ttgtgaatct ggcctgtgca gtgcagacgc     1740

tgctgaggac acccaactgg aggccacgct ttcgatatta ccactggacc ctctccttcc     1800

tgggcatgag cctctgcctg gccctcatgt tcatctgctc ctggtattat gcactggtag     1860

ccatgctcat tgctggactc atctacaagt acattgagta ccgtggggca gagaaggagt     1920

ggggcgatgg gatacgaggt ctgtctctca gtgcggctcg ctatgccctc ttacgcctgg     1980

aggaagggcc cccacacacc aagaactgga ggccacagct gctggtgctg gtgcgtgtgg     2040

accaagacca gaatgtggtg cacccccagc tgctctcact gacctcccag ctgaaggcag     2100

ggaagggcct gaccatcgtg ggctctgtcc ttgagggcac ctttctggaa aatcatccac     2160

aggcccagcg ggcagaagag tctatcaggc gcctgatgga ggcagagaag gtgaagggct     2220

tctgccaggt ggtgatctcc tccaacttgc gtgatggcgt gtcccatctg atccagtccg     2280

ggggcctcgg ggggctgcag cacaacactg tgcttgttgg ctggccccgc aactggcgcc     2340

agaaggaaga tcatcagacg tggaggaact tcattgagct ggtccgggaa accacagctg     2400

gccacttagc cctgctggtc accaagaacg tttccatgtt tcctgggaac cctgagcgct     2460

tctctgaggg cagcatcgac gtttggtgga ttgtgcacga tggaggcatg ctcatgctgc     2520

tgcccttcct gctgcggcac cacaaggtct ggcggaagtg caagatgcgt atcttcactg     2580

tggcccagat ggatgacaat agcatccaga tgaagaagga tctgaccaca tttctgtatc     2640

atttacgcat cactgcggag gtcgaggtgg tggagatgca tgagagcgac atctcagctt     2700

acacctatga gaagacgttg gtgatggagc agcgttccca gatcctcaaa cagatgcatt     2760

taaccaagaa tgagcgggag cgggagatcc agagtatcac agatgagtca cgaggctcaa     2820

tccggagaaa gaatccagcc aacacgcggc tccgcctgaa cgtcccagaa gagacggctg     2880

gtgacagtga agagaagcca gaggaggagg tgcagctgat ccacgatcag agtgctccca     2940

gctgccccag cagctccccg tccccagggg aggagcctga gggggaaggg gagacagatc     3000

cggagaaggt gcatctcacc tggaccaagg acaagtcggt ggcagagaag aataagggcc     3060

ccagtcctgt ctcctctgag ggcatcaagg acttcttcag catgaagccg gagtgggaga     3120

acttgaacca gtccaacgtg cggcgcatgc acacggccgt gcggctgaac gaggtcatcg     3180

tgaagaaatc ccgggacgcc aagcttgttt tgctcaacat gcctgggcct ccccgcaacc     3240

gcaatggtga tgaaaactac atggagtttc tcgaggtcct cacagagcac ctggaccggg     3300

tgatgctggt ccgcggtggt ggccgagagg tcatcaccat ctactcctga gaaccaggtc     3360

ctgccacccg ggcccgagcg cgcccggccc gcggctccgg agccctcgcc gcgccccccg     3420

ccgctgtcac cgtttacata cagaccctgt gcccgtgtcc tggcccctta ccccgctgcc     3480

tgaagcccgg aggccacgcc tgttggggct gattcggaga gggcgccccg ccgcgcagag     3540

accagagctc ctcagtgcca gtttggcccc tgggtcttcg ctgccctttt tctaagcccg     3600

gcctcgtctc gccggaggag acgctgcaat aaaggttggg agaaggcgcg gaaaggagag     3660

gagctggggc cttggggacc cccaggtagt ccatgcggcc cattcctccc cttcccactc     3720

ccgccgcggt cctcgctctg cgctcctccg gcgctgctcc ctggctcccg gcggcccgga     3780

ggcccgcggg gtgggaaggc cgcgcttgcc gtctccgccg ccccttctcg ccgagccgtg     3840

gggcgcgggc ggccgagcct atacatagtg tacaggagac atcgcgtgta tttttaacgt     3900

ccccatattt atgtgactag aagcgcaaca gacttctcgc catagtcgag ctctcccgct     3960

gggggcactg cggggaggcg aggcctcggg aagctgaatt ttccttgacg tccaagagtt     4020

tgagagcgaa agtgctttag gcccaggcgg gggtcgtggc ctcgttccct cgacacctcc     4080

gtcctgctct cgcctcttcg ccctttccgc gcgcccttgg cttcccaccc tcctctccag     4140

tccttttccg agatgaggtg agacaagggt ccaacttttc ctggattcgc ctcccagcgg     4200

acgtgagctt ccactgcggc tgcagagacg cgagcaacct cttctcatcg gctcttatgc     4260

aagttggggc caggataggg gaggggtgct cctcaagagg aagaaaccga gaggcccgcg     4320

ccccaccgag gaagccccgc cccggtgcct tcgctgggga gcaggcgtct ctcctcagtc     4380

ggcttgtcgc ctgctccccg tatcccatgg ctcctcgcca aagactgaaa ttgtggagct     4440

ggagggcgcc ccctccccgg agtttcctcc ctgggacaag tgagggagga gggggccgat     4500

tctggtttag gggccggacc cactgagagg ccccagagcc gcccgtgatg ttcctccccc     4560

gtccccatct ggcagctcct gtctcgcctg agggacccag ccgccttctc cgtgctctgg     4620

ggccgggcct cgctgcttag cagcggcctc tagctccgtc tcccggggac ctgggcctga     4680

gggagggctg gagtcagcac gcgctttgtc cttagcgcct gtctgctctc ctctaactag     4740

gacccagggc ctttggcttc cccagctcat ccttggccct tccgctccac cagcctggtc     4800

tgaggcgtgc tctgtcctta gagaaggcgc ggtggccggg ttcccttccc ctagggcaca     4860

ttactaaggg ggtcaggcac tgcatgctcg ttccagcacc atctgggact gggtacagta     4920

cctccagccc cagggccctg acctgcgcac ctagcttgac atctcacgca cctcccagag     4980

ctggcgccac tgagtaatcc ggacctcacc acctcttttc ctttgagccc aaggcagagc     5040

tagagctgga gctggcgcca cccagacagc gtcaggtgtg gctggggtag gtttggaggt     5100

ctgccagtta cgccaagtcc cctctgagat tcgatcaggg gactggatag attctttcag     5160

gtactcaatc aggaagctgg aggtgttaga caccagcccc ctgcatcctt cagtagacct     5220

ccctctgaac accacagcca ggtcctgcct tctgggggcc tgaatattcc agagctgatg     5280

tgatgggctg tgcagaaggg ggctgtatca acatcaatta gggaaccaaa gttgcactat     5340

ctgggcccag attgtctggt tggcaagagc aaagtttccg ttgatgaaac agacatccca     5400

caacaaaaac ccaagttttc tgtgctacat gtgcaatatt tgttatgaat gttatcacaa     5460

gtcattcatc aagttatctt tataatcact gtagttagat gtttcatgtc cattcaagtg     5520

acttttattc tgagtgcaat atttcaatag ccttgtagtg ataactagtg ttgcttttgt     5580

ttagatgatc tatgtgcagg gcaatgcaat gaagttgaaa ccccttggta ataggagagg     5640

ttgcaaacca aatcaagagt atttattact attactgcta ttattattag gcctgccttt     5700

aattttcagt gtaagtgttc agtatgccgc atcctgcctc agtattgatc ttgtgttctt     5760

tgtgccaata tgaaaaggag agggttggtt ctttccttta ttgttgaatg ctcccattta     5820

atgctttatg gcttttactg tattactttt ttagactccc gtctgcacaa aatgcaataa     5880

aaataatttt attataaaaa aaaaaa                                          5906


<210>  4
<211>  1116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Met Pro Asn Asn Leu Thr Asp Cys Glu Asp Gly Asp Gly Gly Ala Asn 
1               5                   10                  15      


Pro Gly Asp Gly Asn Pro Lys Glu Ser Ser Pro Phe Ile Asn Ser Thr 
            20                  25                  30          


Asp Thr Glu Lys Gly Lys Glu Tyr Asp Gly Lys Asn Met Ala Leu Phe 
        35                  40                  45              


Glu Glu Glu Met Asp Thr Ser Pro Met Val Ser Ser Leu Leu Ser Gly 
    50                  55                  60                  


Leu Ala Asn Tyr Thr Asn Leu Pro Gln Gly Ser Arg Glu His Glu Glu 
65                  70                  75                  80  


Ala Glu Asn Asn Glu Gly Gly Lys Lys Lys Pro Val Gln Ala Pro Arg 
                85                  90                  95      


Met Gly Thr Phe Met Gly Val Tyr Leu Pro Cys Leu Gln Asn Ile Phe 
            100                 105                 110         


Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Val Val Gly Ile Ala Gly 
        115                 120                 125             


Ile Met Glu Ser Phe Cys Met Val Phe Ile Cys Cys Ser Cys Thr Met 
    130                 135                 140                 


Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr Asn Gly Val Val Pro 
145                 150                 155                 160 


Ala Gly Gly Ser Tyr Tyr Met Ile Ser Arg Ser Leu Gly Pro Glu Phe 
                165                 170                 175     


Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly Thr Thr Phe Ala Gly 
            180                 185                 190         


Ala Met Tyr Ile Leu Gly Thr Ile Glu Ile Leu Leu Ala Tyr Leu Phe 
        195                 200                 205             


Pro Ala Met Ala Ile Phe Lys Ala Glu Asp Ala Ser Gly Glu Ala Ala 
    210                 215                 220                 


Ala Met Leu Asn Asn Met Arg Val Tyr Gly Thr Cys Val Leu Thr Cys 
225                 230                 235                 240 


Met Ala Thr Val Val Phe Val Gly Val Lys Tyr Val Asn Lys Phe Ala 
                245                 250                 255     


Leu Val Phe Leu Gly Cys Val Ile Leu Ser Ile Leu Ala Ile Tyr Ala 
            260                 265                 270         


Gly Val Ile Lys Ser Ala Phe Asp Pro Pro Asn Phe Pro Ile Cys Leu 
        275                 280                 285             


Leu Gly Asn Arg Thr Leu Ser Arg His Gly Phe Asp Val Cys Ala Lys 
    290                 295                 300                 


Leu Ala Trp Glu Gly Asn Glu Thr Val Thr Thr Arg Leu Trp Gly Leu 
305                 310                 315                 320 


Phe Cys Ser Ser Arg Phe Leu Asn Ala Thr Cys Asp Glu Tyr Phe Thr 
                325                 330                 335     


Arg Asn Asn Val Thr Glu Ile Gln Gly Ile Pro Gly Ala Ala Ser Gly 
            340                 345                 350         


Leu Ile Lys Glu Asn Leu Trp Ser Ser Tyr Leu Thr Lys Gly Val Ile 
        355                 360                 365             


Val Glu Arg Ser Gly Met Thr Ser Val Gly Leu Ala Asp Gly Thr Pro 
    370                 375                 380                 


Ile Asp Met Asp His Pro Tyr Val Phe Ser Asp Met Thr Ser Tyr Phe 
385                 390                 395                 400 


Thr Leu Leu Val Gly Ile Tyr Phe Pro Ser Val Thr Gly Ile Met Ala 
                405                 410                 415     


Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln Lys Ser Ile Pro 
            420                 425                 430         


Thr Gly Thr Ile Leu Ala Ile Ala Thr Thr Ser Ala Val Tyr Ile Ser 
        435                 440                 445             


Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val Val Leu Arg Asp 
    450                 455                 460                 


Lys Phe Gly Glu Ala Val Asn Gly Asn Leu Val Val Gly Thr Leu Ala 
465                 470                 475                 480 


Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe Phe Ser Thr Cys 
                485                 490                 495     


Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg Leu Leu Gln Ala 
            500                 505                 510         


Ile Ser Arg Asp Gly Ile Val Pro Phe Leu Gln Val Phe Gly His Gly 
        515                 520                 525             


Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu Thr Ala Cys Ile 
    530                 535                 540                 


Cys Glu Ile Gly Ile Leu Ile Ala Ser Leu Asp Glu Val Ala Pro Ile 
545                 550                 555                 560 


Leu Ser Met Phe Phe Leu Met Cys Tyr Met Phe Val Asn Leu Ala Cys 
                565                 570                 575     


Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg Pro Arg Phe Arg 
            580                 585                 590         


Tyr Tyr His Trp Thr Leu Ser Phe Leu Gly Met Ser Leu Cys Leu Ala 
        595                 600                 605             


Leu Met Phe Ile Cys Ser Trp Tyr Tyr Ala Leu Val Ala Met Leu Ile 
    610                 615                 620                 


Ala Gly Leu Ile Tyr Lys Tyr Ile Glu Tyr Arg Gly Ala Glu Lys Glu 
625                 630                 635                 640 


Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala Ala Arg Tyr Ala 
                645                 650                 655     


Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys Asn Trp Arg Pro 
            660                 665                 670         


Gln Leu Leu Val Leu Val Arg Val Asp Gln Asp Gln Asn Val Val His 
        675                 680                 685             


Pro Gln Leu Leu Ser Leu Thr Ser Gln Leu Lys Ala Gly Lys Gly Leu 
    690                 695                 700                 


Thr Ile Val Gly Ser Val Leu Glu Gly Thr Phe Leu Glu Asn His Pro 
705                 710                 715                 720 


Gln Ala Gln Arg Ala Glu Glu Ser Ile Arg Arg Leu Met Glu Ala Glu 
                725                 730                 735     


Lys Val Lys Gly Phe Cys Gln Val Val Ile Ser Ser Asn Leu Arg Asp 
            740                 745                 750         


Gly Val Ser His Leu Ile Gln Ser Gly Gly Leu Gly Gly Leu Gln His 
        755                 760                 765             


Asn Thr Val Leu Val Gly Trp Pro Arg Asn Trp Arg Gln Lys Glu Asp 
    770                 775                 780                 


His Gln Thr Trp Arg Asn Phe Ile Glu Leu Val Arg Glu Thr Thr Ala 
785                 790                 795                 800 


Gly His Leu Ala Leu Leu Val Thr Lys Asn Val Ser Met Phe Pro Gly 
                805                 810                 815     


Asn Pro Glu Arg Phe Ser Glu Gly Ser Ile Asp Val Trp Trp Ile Val 
            820                 825                 830         


His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu Leu Arg His His 
        835                 840                 845             


Lys Val Trp Arg Lys Cys Lys Met Arg Ile Phe Thr Val Ala Gln Met 
    850                 855                 860                 


Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Thr Thr Phe Leu Tyr 
865                 870                 875                 880 


His Leu Arg Ile Thr Ala Glu Val Glu Val Val Glu Met His Glu Ser 
                885                 890                 895     


Asp Ile Ser Ala Tyr Thr Tyr Glu Lys Thr Leu Val Met Glu Gln Arg 
            900                 905                 910         


Ser Gln Ile Leu Lys Gln Met His Leu Thr Lys Asn Glu Arg Glu Arg 
        915                 920                 925             


Glu Ile Gln Ser Ile Thr Asp Glu Ser Arg Gly Ser Ile Arg Arg Lys 
    930                 935                 940                 


Asn Pro Ala Asn Thr Arg Leu Arg Leu Asn Val Pro Glu Glu Thr Ala 
945                 950                 955                 960 


Gly Asp Ser Glu Glu Lys Pro Glu Glu Glu Val Gln Leu Ile His Asp 
                965                 970                 975     


Gln Ser Ala Pro Ser Cys Pro Ser Ser Ser Pro Ser Pro Gly Glu Glu 
            980                 985                 990         


Pro Glu Gly Glu Gly Glu Thr Asp  Pro Glu Lys Val His  Leu Thr Trp 
        995                 1000                 1005             


Thr Lys  Asp Lys Ser Val Ala  Glu Lys Asn Lys Gly  Pro Ser Pro 
    1010                 1015                 1020             


Val Ser  Ser Glu Gly Ile Lys  Asp Phe Phe Ser Met  Lys Pro Glu 
    1025                 1030                 1035             


Trp Glu  Asn Leu Asn Gln Ser  Asn Val Arg Arg Met  His Thr Ala 
    1040                 1045                 1050             


Val Arg  Leu Asn Glu Val Ile  Val Lys Lys Ser Arg  Asp Ala Lys 
    1055                 1060                 1065             


Leu Val  Leu Leu Asn Met Pro  Gly Pro Pro Arg Asn  Arg Asn Gly 
    1070                 1075                 1080             


Asp Glu  Asn Tyr Met Glu Phe  Leu Glu Val Leu Thr  Glu His Leu 
    1085                 1090                 1095             


Asp Arg  Val Met Leu Val Arg  Gly Gly Gly Arg Glu  Val Ile Thr 
    1100                 1105                 1110             


Ile Tyr  Ser 
    1115     


<210>  5
<211>  7985
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5
agaaatggac cgagcggacc cgccgccgca cgcaccctgc tccactccaa gctcctaagg       60

gctcctggcg cgccgcgtag ccttggcgag gtccgcgctg gggtgcggag agcgaaggga      120

actggagagc catgtagatc caggctctcg cccgcccgcc tccttcggga tcgaatcaag      180

ggctcccata gtgttaggag ggggcgagag tgctgtttat cgtcatttgc ctcggagctt      240

cgagagaggg tggtattttg cttttccgcc ccgcatcctc cggaactccc tgcaccggag      300

agaggacggc gtctccaggt tgctggcaac cggtgagaat gggggtaggg aaggaacatt      360

ttcgccgtag ctgctccgta aagcgattgt ccaactgaga ggggcgtcgg acgagtggac      420

cagggcggcg agtttgcccg gcgcgtctcg gatgctgctg cggcggccgc cgcggctccc      480

gccagggcac tgcaaagacg acctgccgca ttcccactcg ggctctccgc tgactcagca      540

ccgcccctgc gccaagccag ccggccagcg tgcatcgatc gccctggtgg gagcttagaa      600

ggcggcaggc gaagaggggt aggagggggg agagccgagg agaagcagag agggtggcag      660

gcgtggggat ctgccgagcc ggcactgcac cgggtcctag gaaggctctc ggaggggagg      720

ggaggccagg gcgacccccg aagcaatggc ccagtccgct agaacggcac tgcgttaagg      780

cacctgggat caggaagaaa tatctaaaca acaacaacag aaaaccaaca aacccccaaa      840

cccaaaccca accctctgca aaaagctgca cccggcccgc aggcgagggg gattccaaac      900

tgagtgaaag gcagggtgga ggggaaggca gcgagaggca aagtcgcaga tctcccgacc      960

tgctcgtgtt gaagcacctc cccctgggcg tgagggagac gcgcgctccg gtgggggggc     1020

cgcttgggtc ccccccaccc ctggtccctg gctgcttccc accccgggct ctctcctggc     1080

ctcccacccc cgcgcccggc ttccaccatg acggtgatgt ctggggagaa cgtggacgag     1140

gcttcggccg ccccgggcca cccccaggat ggcagctacc cccggcaggc cgaccacgac     1200

gaccacgagt gctgcgagcg cgtggtgatc aacatctccg ggctgcgctt cgagacgcag     1260

ctcaagaccc tggcgcagtt ccccaacacg ctgctgggca accctaagaa acgcatgcgc     1320

tacttcgacc ccctgaggaa cgagtacttc ttcgaccgca accggcccag cttcgacgcc     1380

atcctctact actaccagtc cggcggccgc ctgcggaggc cggtcaacgt gcccctggac     1440

atgttctccg aggagatcaa gttttacgag ttgggcgagg aggccatgga gaagttccgg     1500

gaggacgagg gcttcatcaa ggaggaggag cgccctctgc ccgagaagga gtaccagcgc     1560

caggtgtggc tgctcttcga gtaccccgag agctcggggc ccgccagggt catcgccatc     1620

gtctccgtca tggtcatcct catctccatc gtcatctttt gcctggagac gctccccgag     1680

ctgaaggatg acaaggactt cacgggcacc gtccaccgca tcgacaacac cacggtcatc     1740

tacaattcca acatcttcac agaccccttc ttcatcgtgg aaacgctgtg tatcatctgg     1800

ttctccttcg agctggtggt gcgcttcttc gcctgcccca gcaagacgga cttcttcaaa     1860

aacatcatga acttcataga cattgtggcc atcattcctt atttcatcac gctgggcacc     1920

gagatagctg agcaggaagg aaaccagaag ggcgagcagg ccacctccct ggccatcctc     1980

agggtcatcc gcttggtaag ggtttttaga atcttcaagc tctcccgcca ctctaagggc     2040

ctccagatcc tgggccagac cctcaaagct agtatgagag agctagggct gctcatcttt     2100

ttcctcttca tcggggtcat cctgttttct agtgcagtgt actttgccga ggcggaagaa     2160

gctgagtcgc acttctccag tatccccgat gctttctggt gggcggtggt gtccatgacc     2220

actgtaggat acggtgacat gtaccctgtg acaattggag gcaagatcgt gggctccttg     2280

tgtgccatcg ctggtgtgct aacaattgcc ctgcccgtac ctgtcattgt gtccaatttc     2340

aactatttct accaccgaga aactgagggg gaagagcagg ctcagttgct ccacgtcagt     2400

tcccctaact tagcctctga cagtgacctc agtcgccgca gttcctctac tatgagcaag     2460

tctgagtaca tggagatcga agaggatatg aataatagca tagcccatta tagacaggtc     2520

aatatcagaa ctgccaattg caccactgct aaccaaaact gcgttaataa gagcaagcta     2580

ctgaccgatg tttaaaaaac aaaggcaagc aaacaaaaaa gccccactta gcagctcaaa     2640

agacttaaaa aacaaaacag aaaacctagt gactcatgtc acgctttgta gatactttac     2700

taagtagact tggaatgctc tatttaactg tcaatgcgtt gttgcattga ggattttggg     2760

ggtggtgaac cagaagcttt caagatccat gacaaaataa actattttcc ttttattaaa     2820

aaatgggaaa agagagagta ttttctaaaa ctggcttaaa aagattcagt ccacgaacta     2880

gtctaggtaa aataataatc atatgcttcc ccaaactgaa acatttttaa tgctttggtt     2940

tctttaactt ttttaaaaac tcagaacaag atgatcactt agaaatatga aattgaaatt     3000

cgcatgggac tccagtaaaa catctttgca aactgcgtag cacattgaag acagtgcatc     3060

agatgtatta tatgtaacat gatagaccag ccaaaatgga caatgaatag atatttttat     3120

ttcgatcaac tgaactgcat attacaaggt gaaaaaagaa aactccgatt acttaagact     3180

ggttcacaaa gcaccttata aattggatac tggtcctgat ctgtagggat ttccccctgg     3240

gcccattctc tttctaatcc agattattct ctaagaaaaa gttaactgaa ttaaattaat     3300

tgattcttct gcagtgccgc taaatggtct caactgcaga tgagccaaat acaggtcttt     3360

tctcaccagg cctgcactcc gacccctggc tttcagaact ggatgtaaaa ccttagcctc     3420

cttattgcaa gagagcacaa atgaagttaa atgtaagcat gtttgaatct gatacaattt     3480

attttataat cgcatgctga gaagttaacc cagacaatag gggataagct taagttgaaa     3540

tcgattcttc taaaaataga tcctttttca tttgcattca ccaaaagtgc actcctccat     3600

ttattaacta ttttattagt aaataaagta ctgtatttaa gtgcatatgt tagtcagatg     3660

ggaacaataa ctttttggag ctcaaagcat gttctcttat tcagcattat ggcctatttg     3720

actaagatgt accttgaatt aattaatgca tgatttcagt aataaaaatt ttaaaagtaa     3780

taaaaattac aagtctgtgg ggtgaaaggc ccaatagaaa ttatgggggg tgggggtggg     3840

ggcactcagt caattttcct gcctttgctc agggaaatac caggtttttg tgcaggtata     3900

ggcggagaga ggaccaatat gcccatccct taaagggaag ccatgtgaaa aactcaataa     3960

gtcatcaaag tacatatagc aacacctaag aacaagtatt ctttctagct gaagacaaac     4020

acaagcaaca caaacaagca aacaaacaaa caaacaaaaa ggtgcaatac tgcatgtttt     4080

ttggtgcatt cttaggatgt aaatgaaaat gtttctctat tatatgcatc cgaagcagag     4140

ctgatttttt tttctttgca gtcattcttt gaagtctgta gagacttcag ccctcccctt     4200

gaggctccct gaagaaacta aaccaattga tttaatagtt gcttagtgcc tttatcctgt     4260

acccacagtg aactgtagaa agtgcctcct taacacagct gagaagttag gtagcaaaag     4320

tggggaaggg ttggggcaca gaccttttgc tttttctttt tccattctcg ctctctcatt     4380

tcaccactgt gagaagacca caccacccta aaccctggag aggagagacc caggagggtg     4440

ctgtctctct ggccatctac tagcattggt ccctttgaca gcctgacgct ggatgtgaac     4500

tgagacccat ctttgaactg gacatgaact gtgaacttgt tttttcctct ctccaccaaa     4560

gccaagataa actttttggg aatttgtttc ctatcgaggg ccactttgga cacacaaggc     4620

ttcctcaggt ccagtgtagt gctcctggca cctttcctta tttttttctc tgtcggtaac     4680

agcactttgc aaatctctct gacggtccag tcttttcagg cattgttgtg gatgtgggaa     4740

cactcagttc ataataacct ttcctaggcc ttccctcctg gtctacccct ttcagatatt     4800

tcctgatgcc cctatgatct tcccacctgg cagtcacttc acaggttgaa catctaactt     4860

ctgctgcccc cccgttaccc agcccagaga atggtgggga ccctgttcct ggctgaaaga     4920

gagccacgga acacaggcct ctggagctcg gcagctgccc accggtggag aggtactcac     4980

agcctttcaa aggaccctga ggtggggaat cttcattctg cacttagcat gtggctgcct     5040

gttacctgac attctggccc agcttcttct gaaaatctgt cctgcttctc ccaccccttt     5100

cccccatcct gtcctagaac tagcagtgag gcaatcaccc tagaaactcg agttacaccc     5160

attctggcta actcgattaa aagaaagaac atggatatct tattttccta tgtgactttt     5220

gtgaatctgt gagatgaaca caacacacat cgtggaagat gaggggccaa gaactgcgca     5280

gcatccgact acagggcatt aaaccctccc atgtgatgtc tccttctcgt ctgaacctta     5340

actcattctg gcgattcctt tcctacttgc ttaaaaatcc ccaattagga aaaaaatgcc     5400

aacctcctcc caggcttggg gttatcttga tctttcattt caacgttgag gtctagtgca     5460

cacagaactt gaaacaccgc actctgtcaa cagcaataat ccactcagta ctgtgggatg     5520

gatgggttaa tggatgagaa aacggcacca agactgactt tgggtatttg gtatatttac     5580

cgtggttaca ctctggactg gttgattctt ctgcatgtga tatagaaaaa agtgctgcat     5640

gcggtgaacc tgtcagtctg ggactggggg tgagttgttg ttatgagttt ggggtggtgt     5700

gaggaaagtg aatgctgctt agctcatctg tagctcattg caatgaattc agtaagaatg     5760

gagtacaggg attatctgtg tagcataggc atgcaatgtt tgaccaagct cttaccctcg     5820

cactgtaatg tgttgaaatg tctttgtaga cctgaaggtg cacttaacaa aactgcctat     5880

taagggatga ctattttttg gtttacttat tcatatttat tttagcagcc tttttacctt     5940

ttcttcccct tcctaggcat ggagctgtaa cagctcatgt cctgactatg tgttttctcc     6000

agaaggagaa gacttctgat gtgctgatag ctataattcc tctcttccag tctattgggg     6060

ccctagttca atagggtggc aatagaagag ttggtcacac cagggctgtt agccatccca     6120

gaatctctga agtggttaac tcacctgaag tgatctgaat cagagagacc aaagacattc     6180

atttcctctg tcctcagatt tctagaagac aaattctagc caggaaaact ttctgttttt     6240

gcatctccct tttcccattt gtgcccaact ccccttgcac tccctggaga cttgagttct     6300

gattttcagt tatatcagct cattgggagt gtgttcgtgg gtgagccttg cagaatcaga     6360

taaaccaata gcaagtcctt ctccaggatt ctggccagtg ggcagtcatt tccctgaaat     6420

gaattgtagg gcaggtttag attccactat ggtggacgtg aagcacaggt ggtgtcacaa     6480

tcttgatttg cttgagaatt aaaaaaatac atgtaaatgg taaatgagga atacattttt     6540

ttaaagtaga aatttggttt agcctataaa aggccttctt cacattgtgt atagttacac     6600

gtttttcaaa ttaggtacca tctaaaagtc aataaaaata gtttcctagc cctctcattt     6660

aatataggag acctcaaaac acatgctttt taacaatttt acattttaat tcttagtttg     6720

gtagattgga ttgaaagaaa ggagaaagaa cattagcaga aggcactttc ccattttctt     6780

ccaggaatga cttattcctg gggtggtgag aattggtggg tggtaaccat ccatagtata     6840

aaattgttag aaagaatata aactgccaaa caagcatgtt atcttcaggc ttttccaagc     6900

aagaatgaag tcttttgatg tttatgttca ttttaagaag acaaacaaac taaaatttta     6960

agaccagaca caacccaagt tgaattgtga tctcaggagg tgaactctca ttcaccatgt     7020

ggcatattac tacctgtatt tatatcatgg aatttcaggg tatatgtgaa catgtctagt     7080

atgactcagg taaaccttta aagaatgtat gttacttacc atttttgtaa agaagcaaac     7140

aggagctgaa ttgttaacca aaactgttcc attaccttgg gtcactgtgc aaactaattc     7200

agggtacaga tataaagttt agaagccttg ggattaaatg ccagcctctt tgctcaggca     7260

aaatgaccct gggctttctt gggaagtcca gcatgtatgt aaggggtgag gccctgctga     7320

cctcagggct tttcgcttta aggagattaa ccctagtcac agtgattttc atttaggagc     7380

taactaggag tttactcttt atgacgtgaa acttcaaaga gtatagaaaa cttttgtacc     7440

acaatcaaag aagaagaaat ggtgtatgga aagaaaacaa aacaaaacaa gaaatctctt     7500

gtaaaatatt ccaggtcaaa gttgtctcct ctccaaacct tgcagaagca cctttcttct     7560

cttcagcgca ctgttttggg actgtttatg cagcagatgt aagtagacaa catggactcc     7620

atgtgacatg cctctaatag taaagataaa gtattactga ggttaaaaat aaaaattgag     7680

tagtattaat ttaaagtgca ccatcaggac aacaaaccat ttaagctgaa aaaacgctat     7740

tttatttctt gagtttgcca gttgcttcca ccttgagtta aggacgtgtc tcatcttcac     7800

ctactgcgca ttctcccttc tctaactgtg taatatgtca ggtcaaggac attgaatgtt     7860

atgaattgag aacctaattg atgcgcatag ttttcatcta tgcaatttta cttgcttctg     7920

tcactttacg atctgttcat atttggcatc aattaaagat actttttaag gatcttatca     7980

aggaa                                                                 7985


<210>  6
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Met Thr Val Met Ser Gly Glu Asn Val Asp Glu Ala Ser Ala Ala Pro 
1               5                   10                  15      


Gly His Pro Gln Asp Gly Ser Tyr Pro Arg Gln Ala Asp His Asp Asp 
            20                  25                  30          


His Glu Cys Cys Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe 
        35                  40                  45              


Glu Thr Gln Leu Lys Thr Leu Ala Gln Phe Pro Asn Thr Leu Leu Gly 
    50                  55                  60                  


Asn Pro Lys Lys Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr 
65                  70                  75                  80  


Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr 
                85                  90                  95      


Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Met 
            100                 105                 110         


Phe Ser Glu Glu Ile Lys Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu 
        115                 120                 125             


Lys Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu 
    130                 135                 140                 


Pro Glu Lys Glu Tyr Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro 
145                 150                 155                 160 


Glu Ser Ser Gly Pro Ala Arg Val Ile Ala Ile Val Ser Val Met Val 
                165                 170                 175     


Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Leu 
            180                 185                 190         


Lys Asp Asp Lys Asp Phe Thr Gly Thr Val His Arg Ile Asp Asn Thr 
        195                 200                 205             


Thr Val Ile Tyr Asn Ser Asn Ile Phe Thr Asp Pro Phe Phe Ile Val 
    210                 215                 220                 


Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Val Val Arg Phe 
225                 230                 235                 240 


Phe Ala Cys Pro Ser Lys Thr Asp Phe Phe Lys Asn Ile Met Asn Phe 
                245                 250                 255     


Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu 
            260                 265                 270         


Ile Ala Glu Gln Glu Gly Asn Gln Lys Gly Glu Gln Ala Thr Ser Leu 
        275                 280                 285             


Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
    290                 295                 300                 


Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys 
305                 310                 315                 320 


Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly 
                325                 330                 335     


Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Glu Glu Ala 
            340                 345                 350         


Glu Ser His Phe Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val 
        355                 360                 365             


Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Val Thr Ile Gly 
    370                 375                 380                 


Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile 
385                 390                 395                 400 


Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His 
                405                 410                 415     


Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Leu Leu His Val Ser Ser 
            420                 425                 430         


Pro Asn Leu Ala Ser Asp Ser Asp Leu Ser Arg Arg Ser Ser Ser Thr 
        435                 440                 445             


Met Ser Lys Ser Glu Tyr Met Glu Ile Glu Glu Asp Met Asn Asn Ser 
    450                 455                 460                 


Ile Ala His Tyr Arg Gln Val Asn Ile Arg Thr Ala Asn Cys Thr Thr 
465                 470                 475                 480 


Ala Asn Gln Asn Cys Val Asn Lys Ser Lys Leu Leu Thr Asp Val 
                485                 490                 495 


<210>  7
<211>  1496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7
gaattcgcaa ttaaggagat aataggtatg ccgatcacca tcaacaactt ccgttactcc       60

gacccggtta acaacgacac catcatcatg atggaaccgc cgtactgcaa aggtctagac      120

atctactaca aagccttcaa aatcaccgac cgtatctgga tcgttccgga acgttacgaa      180

tttggtacca aaccggaaga cttcaacccg ccgtcctccc tgatcgaagg tgcttccgaa      240

tactacgacc cgaactacct gcgtaccgac tccgacaaag accgtttcct gcagaccatg      300

gttaaactgt tcaaccgtat caaaaacaac gttgctggtg aagctctgct ggacaaaatc      360

atcaacgcta tcccgtacct gggtaactcc tactccctgc tggacaaatt cgacaccaac      420

tccaactccg tttccttcaa cctgctggaa caggatccgt ccggtgctac caccaaatcc      480

gctatgctga ccaacctgat catcttcggt ccgggtccgg ttctgaacaa aaacgaagtt      540

cgtggtatcg ttctgcgtgt tgacaacaaa aactacttcc cgtgccgtga cggtttcggt      600

tccatcatgc agatggcttt ctgcccggaa tacgtaccga ccttcgacaa cgttatcgaa      660

aacatcacct ccctgaccat cggtaaatcc aaatacttcc aggacccggc tctgctgctg      720

atgcacgaac tgatccacgt tctgcacggt ctgtacggca tgcaggtttc ctcccacgaa      780

atcatcccgt ccaaacagga aatctacatg cagcacacct acccgatctc cgctgaagag      840

ctcttcacct tcggtggtca ggacgctaac ctgatctcca tcgatatcaa aaacgacctg      900

tacgaaaaaa ccctgaacga ctacaaagct atcgctaaca aactgtccca ggttacctcc      960

tgcaacgacc cgaacatcga catcgactcc tacaaacaga tctatcagca gaagtatcag     1020

tttgataagg attccaacgg ccagtatata gtgaacgagg ataagtttca gatactgtat     1080

aactccataa tgtatggctt tactgagata gagctgggca agaagtttaa cataaagact     1140

cgcttaagct atttttccat gaaccacgat cctgtgaaga tacctaacct gctggatgat     1200

actatatata acgatactga gggctttaac atagagtcca aggatctgaa gtccgagtat     1260

aagggccaga acatgagggt gaacactaac gcctttagga acgtcgacgg ttccggtctg     1320

gtttccaaac tgatcggtct gtgcaaaaaa atcatcccgc cgaccaacat ccgtgaaaac     1380

ctgtacaacc gtaccgctta atttaaagca gctgcgatcg taactaagta ataaacggtc     1440

gtaacacaac aattgcattc cggggtttta tgtttcaggt tgggggtggt aagctt         1496


<210>  8
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Met Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val Asn Asn 
1               5                   10                  15      


Asp Thr Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu Asp Ile 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Val Pro Glu 
        35                  40                  45              


Arg Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn Pro Pro Ser Ser 
    50                  55                  60                  


Leu Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro Asn Tyr Leu Arg Thr 
65                  70                  75                  80  


Asp Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu Phe Asn 
                85                  90                  95      


Arg Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu Asp Lys Ile Ile 
            100                 105                 110         


Asn Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser Leu Leu Asp Lys Phe 
        115                 120                 125             


Asp Thr Asn Ser Asn Ser Val Ser Phe Asn Leu Leu Glu Gln Asp Pro 
    130                 135                 140                 


Ser Gly Ala Thr Thr Lys Ser Ala Met Leu Thr Asn Leu Ile Ile Phe 
145                 150                 155                 160 


Gly Pro Gly Pro Val Leu Asn Lys Asn Glu Val Arg Gly Ile Val Leu 
                165                 170                 175     


Arg Val Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe Gly Ser 
            180                 185                 190         


Ile Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro Thr Phe Asp Asn 
        195                 200                 205             


Val Ile Glu Asn Ile Thr Ser Leu Thr Ile Gly Lys Ser Lys Tyr Phe 
    210                 215                 220                 


Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His 
225                 230                 235                 240 


Gly Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile Pro Ser Lys 
                245                 250                 255     


Gln Glu Ile Tyr Met Gln His Thr Tyr Pro Ile Ser Ala Glu Glu Leu 
            260                 265                 270         


Phe Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys 
        275                 280                 285             


Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn 
    290                 295                 300                 


Lys Leu Ser Gln Val Thr Ser Cys Asn Asp Pro Asn Ile Asp Ile Asp 
305                 310                 315                 320 


Ser Tyr Lys Gln Ile Tyr Gln Gln Lys Tyr Gln Phe Asp Lys Asp Ser 
                325                 330                 335     


Asn Gly Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln Ile Leu Tyr Asn 
            340                 345                 350         


Ser Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly Lys Lys Phe Asn 
        355                 360                 365             


Ile Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His Asp Pro Val Lys 
    370                 375                 380                 


Ile Pro Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp Thr Glu Gly Phe 
385                 390                 395                 400 


Asn Ile Glu Ser Lys Asp Leu Lys Ser Glu Tyr Lys Gly Gln Asn Met 
                405                 410                 415     


Arg Val Asn Thr Asn Ala Phe Arg Asn Val Asp Gly Ser Gly Leu Val 
            420                 425                 430         


Ser Lys Leu Ile Gly Leu Cys Lys Lys Ile Ile Pro Pro Thr Asn Ile 
        435                 440                 445             


Arg Glu Asn Leu Tyr Asn Arg Thr Ala 
    450                 455         


<210>  9
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9
atggccaact tcacacctgt caatggcagc tcgggcaatc agtccgtgcg cctggtcacg       60

tcatcatccc acaatcgcta tgagacggtg gaaatggtct tcattgccac agtgacaggc      120

tccctgagcc tggtgactgt cgtgggcaac atcctggtga tgctgtccat caaggtcaac      180

aggcagctgc agacagtcaa caactacttc ctcttcagcc tggcgtgtgc tgatctcatc      240

ataggcgcct tctccatgaa cctctacacc gtgtacatca tcaagggcta ctggcccctg      300

ggcgccgtgg tctgcgacct gtggctggcc ctggactgcg tggtgagcaa cgcctccgtc      360

atgaaccttc tcatcatcag ctttgaccgc tacttctgcg tcaccaagcc tctcacctac      420

cctgcccggc gcaccaccaa gatggcaggc ctcatgattg ctgctgcctg ggtactgtcc      480

ttcgtgctct gggcgcctgc catcttgttc tggcagtttg tggtgggtaa gcggacggtg      540

cccgacaacc agtgcttcat ccagttcctg tccaacccag cagtgacctt tggcacagcc      600

attgctggct tctacctgcc tgtggtcatc atgacggtgc tgtacatcca catctccctg      660

gccagtcgca gccgagtcca caagcaccgg cccgagggcc cgaaggagaa gaaagccaag      720

acgctggcct tcctcaagag cccactaatg aagcagagcg tcaagaagcc cccgcccggg      780

gaggccgccc gggaggagct gcgcaatggc aagctggagg aggccccccc gccagcgctg      840

ccaccgccac cgcgccccgt ggctgataag gacacttcca atgagtccag ctcaggcagt      900

gccacccaga acaccaagga acgcccagcc acagagctgt ccaccacaga ggccaccacg      960

cccgccatgc ccgcccctcc cctgcagccg cgggccctca acccagcctc cagatggtcc     1020

aagatccaga ttgtgacgaa gcagacaggc aatgagtgtg tgacagccat tgagattgtg     1080

cctgccacgc cggctggcat gcgccctgcg gccaacgtgg cccgcaagtt cgccagcatc     1140

gctcgcaacc aggtgcgcaa gaagcggcag atggcggccc gggagcgcaa agtgacacga     1200

acgatctttg ccattctgct ggccttcatc ctcacctgga cgccctacaa cgtcatggtc     1260

ctggtgaaca ccttctgcca gagctgcatc cctgacacgg tgtggtccat tggctactgg     1320

ctctgctacg tcaacagcac catcaaccct gcctgctatg ctctgtgcaa cgccaccttt     1380

aaaaagacct tccggcacct gctgctgtgc cagtatcgga acatcggcac tgccaggcgg     1440

gatccaccgg tc                                                         1452


<210>  10
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Met Ala Asn Phe Thr Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val 
1               5                   10                  15      


Arg Leu Val Thr Ser Ser Ser His Asn Arg Tyr Glu Thr Val Glu Met 
            20                  25                  30          


Val Phe Ile Ala Thr Val Thr Gly Ser Leu Ser Leu Val Thr Val Val 
        35                  40                  45              


Gly Asn Ile Leu Val Met Leu Ser Ile Lys Val Asn Arg Gln Leu Gln 
    50                  55                  60                  


Thr Val Asn Asn Tyr Phe Leu Phe Ser Leu Ala Cys Ala Asp Leu Ile 
65                  70                  75                  80  


Ile Gly Ala Phe Ser Met Asn Leu Tyr Thr Val Tyr Ile Ile Lys Gly 
                85                  90                  95      


Tyr Trp Pro Leu Gly Ala Val Val Cys Asp Leu Trp Leu Ala Leu Asp 
            100                 105                 110         


Cys Val Val Ser Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe 
        115                 120                 125             


Asp Arg Tyr Phe Cys Val Thr Lys Pro Leu Thr Tyr Pro Ala Arg Arg 
    130                 135                 140                 


Thr Thr Lys Met Ala Gly Leu Met Ile Ala Ala Ala Trp Val Leu Ser 
145                 150                 155                 160 


Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Phe Val Val Gly 
                165                 170                 175     


Lys Arg Thr Val Pro Asp Asn Gln Cys Phe Ile Gln Phe Leu Ser Asn 
            180                 185                 190         


Pro Ala Val Thr Phe Gly Thr Ala Ile Ala Gly Phe Tyr Leu Pro Val 
        195                 200                 205             


Val Ile Met Thr Val Leu Tyr Ile His Ile Ser Leu Ala Ser Arg Ser 
    210                 215                 220                 


Arg Val His Lys His Arg Pro Glu Gly Pro Lys Glu Lys Lys Ala Lys 
225                 230                 235                 240 


Thr Leu Ala Phe Leu Lys Ser Pro Leu Met Lys Gln Ser Val Lys Lys 
                245                 250                 255     


Pro Pro Pro Gly Glu Ala Ala Arg Glu Glu Leu Arg Asn Gly Lys Leu 
            260                 265                 270         


Glu Glu Ala Pro Pro Pro Ala Leu Pro Pro Pro Pro Arg Pro Val Ala 
        275                 280                 285             


Asp Lys Asp Thr Ser Asn Glu Ser Ser Ser Gly Ser Ala Thr Gln Asn 
    290                 295                 300                 


Thr Lys Glu Arg Pro Ala Thr Glu Leu Ser Thr Thr Glu Ala Thr Thr 
305                 310                 315                 320 


Pro Ala Met Pro Ala Pro Pro Leu Gln Pro Arg Ala Leu Asn Pro Ala 
                325                 330                 335     


Ser Arg Trp Ser Lys Ile Gln Ile Val Thr Lys Gln Thr Gly Asn Glu 
            340                 345                 350         


Cys Val Thr Ala Ile Glu Ile Val Pro Ala Thr Pro Ala Gly Met Arg 
        355                 360                 365             


Pro Ala Ala Asn Val Ala Arg Lys Phe Ala Ser Ile Ala Arg Asn Gln 
    370                 375                 380                 


Val Arg Lys Lys Arg Gln Met Ala Ala Arg Glu Arg Lys Val Thr Arg 
385                 390                 395                 400 


Thr Ile Phe Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr 
                405                 410                 415     


Asn Val Met Val Leu Val Asn Thr Phe Cys Gln Ser Cys Ile Pro Asp 
            420                 425                 430         


Thr Val Trp Ser Ile Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile 
        435                 440                 445             


Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys Lys Thr Phe 
    450                 455                 460                 


Arg His Leu Leu Leu Cys Gln Tyr Arg Asn Ile Gly Thr Ala Arg Arg 
465                 470                 475                 480 


Asp Pro Pro Val 
                


<210>  11
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gactggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gaccctttaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagtgt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggtactcga accttttggt ctggctgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagaccgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataatgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caaggaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggacac ggaataccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatga tgagaacggg caataacttt accttcagct acacattcga ggacgcgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacttgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatact tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  12
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Asp Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Cys Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Ala Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Glu Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Thr Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Met Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Ala Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  13
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  14
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  15
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Glu Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Ser Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Tyr Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Ile 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  16
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Arg 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Gln Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Ile Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Thr Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn Gly 
            500                 505                 510         


Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly Lys 
    530                 535                 540                 


Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg Phe 
                565                 570                 575     


Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala Thr 
            580                 585                 590         


Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Ala Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735 


