                         SEQUENCE LISTING

<110>  ONCIMMUNE LIMITED
 
<120>  ANTIBODY ASSAY

<130>  NLW/NTR/P209609WO00

<150>  CN202010677754.6
<151>  2020-07-14

<150>  GB2017434.8
<151>  2020-11-04

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  2
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser His Trp Ala Pro Glu Trp Lys Arg Ala Glu Ala Asn Pro Arg 
1               5                   10                  15      


Asp Leu Gly Ala Ser Trp Asp Val Arg Gly Ser Arg Gly Ser Gly Trp 
            20                  25                  30          


Ser Gly Pro Phe Gly His Gln Gly Pro Arg Ala Ala Gly Ser Arg Glu 
        35                  40                  45              


Pro Pro Leu Cys Phe Lys Ile Lys Asn Asn Met Val Gly Val Val Ile 
    50                  55                  60                  


Gly Tyr Ser Gly Ser Lys Ile Lys Asp Leu Gln His Ser Thr Asn Thr 
65                  70                  75                  80  


Lys Ile Gln Ile Ile Asn Gly Glu Ser Glu Ala Lys Val Arg Ile Phe 
                85                  90                  95      


Gly Asn Arg Glu Met Lys Ala Lys Ala Lys Ala Ala Ile Glu Thr Leu 
            100                 105                 110         


Ile Arg Lys Gln Glu Ser Tyr Asn Ser Glu Ser Ser Val Asp Asn Ala 
        115                 120                 125             


Ala Ser Gln Thr Pro Ile Gly Arg Asn Leu Gly Arg Asn Asp Ile Val 
    130                 135                 140                 


Gly Glu Ala Glu Pro Leu Ser Asn Trp Asp Arg Ile Arg Ala Ala Val 
145                 150                 155                 160 


Val Glu Cys Glu Lys Arg Lys Trp Ala Asp Leu Pro Pro Val Lys Lys 
                165                 170                 175     


Asn Phe Tyr Ile Glu Ser Lys Ala Thr Ser Cys Met Ser Glu Met Gln 
            180                 185                 190         


Val Ile Asn Trp Arg Lys Glu Asn Phe Asn Ile Thr Cys Asp Asp Leu 
        195                 200                 205             


Lys Ser Gly Glu Lys Arg Leu Ile Pro Lys Pro Thr Cys Arg Phe Lys 
    210                 215                 220                 


Asp Ala Phe Gln Gln Tyr Pro Asp Leu Leu Lys Ser Ile Ile Arg Val 
225                 230                 235                 240 


Gly Ile Leu Lys Pro Thr Pro Ile Gln Ser Gln Ala Trp Pro Ile Ile 
                245                 250                 255     


Leu Gln Gly Ile Asp Leu Ile Val Val Ala Gln Thr Gly Thr Gly Lys 
            260                 265                 270         


Thr Leu Ser Tyr Leu Met Pro Gly Phe Ile His Leu Asp Ser Gln Pro 
        275                 280                 285             


Ile Ser Arg Glu Gln Arg Asn Gly Pro Gly Met Leu Val Leu Thr Pro 
    290                 295                 300                 


Thr Arg Glu Leu Ala Leu His Val Glu Ala Glu Cys Ser Lys Tyr Ser 
305                 310                 315                 320 


Tyr Lys Gly Leu Lys Ser Ile Cys Ile Tyr Gly Gly Arg Asn Arg Asn 
                325                 330                 335     


Gly Gln Ile Glu Asp Ile Ser Lys Gly Val Asp Ile Ile Ile Ala Thr 
            340                 345                 350         


Pro Gly Arg Leu Asn Asp Leu Gln Met Asn Asn Ser Val Asn Leu Arg 
        355                 360                 365             


Ser Ile Thr Tyr Leu Val Ile Asp Glu Ala Asp Lys Met Leu Asp Met 
    370                 375                 380                 


Glu Phe Glu Pro Gln Ile Arg Lys Ile Leu Leu Asp Val Arg Pro Asp 
385                 390                 395                 400 


Arg Gln Thr Val Met Thr Ser Ala Thr Trp Pro Asp Thr Val Arg Gln 
                405                 410                 415     


Leu Ala Leu Ser Tyr Leu Lys Asp Pro Met Ile Val Tyr Val Gly Asn 
            420                 425                 430         


Leu Asn Leu Val Ala Val Asn Thr Val Lys Gln Asn Ile Ile Val Thr 
        435                 440                 445             


Thr Glu Lys Glu Lys Arg Ala Leu Thr Gln Glu Phe Val Glu Asn Met 
    450                 455                 460                 


Ser Pro Asn Asp Lys Val Ile Met Phe Val Ser Gln Lys His Ile Ala 
465                 470                 475                 480 


Asp Asp Leu Ser Ser Asp Phe Asn Ile Gln Gly Ile Ser Ala Glu Ser 
                485                 490                 495     


Leu His Gly Asn Ser Glu Gln Ser Asp Gln Glu Arg Ala Val Glu Asp 
            500                 505                 510         


Phe Lys Ser Gly Asn Ile Lys Ile Leu Ile Thr Thr Asp Ile Val Ser 
        515                 520                 525             


Arg Gly Leu Asp Leu Asn Asp Val Thr His Val Tyr Asn Tyr Asp Phe 
    530                 535                 540                 


Pro Arg Asn Ile Asp Val Tyr Val His Arg Val Gly Tyr Ile Gly Arg 
545                 550                 555                 560 


Thr Gly Lys Thr Gly Thr Ser Val Thr Leu Ile Thr Gln Arg Asp Ser 
                565                 570                 575     


Lys Met Ala Gly Glu Leu Ile Lys Ile Leu Asp Arg Ala Asn Gln Ser 
            580                 585                 590         


Val Pro Glu Asp Leu Val Val Met Ala Glu Gln Tyr Lys Leu Asn Gln 
        595                 600                 605             


Gln Lys Arg His Arg Glu Thr Arg Ser Arg Glu Pro Gly Gln Arg Arg 
    610                 615                 620                 


Lys Glu Phe Tyr Phe Leu Ser 
625                 630     


<210>  3
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Phe Ser Arg Arg Ser Phe His Arg Ser Leu Ser Ser Ser Leu 
1               5                   10                  15      


Gln Ala Pro Val Val Ser Thr Val Gly Met Gln Arg Leu Gly Thr Thr 
            20                  25                  30          


Pro Ser Val Tyr Gly Gly Ala Gly Gly Arg Gly Ile Arg Ile Ser Asn 
        35                  40                  45              


Ser Arg His Thr Val Asn Tyr Gly Ser Asp Leu Thr Gly Gly Gly Asp 
    50                  55                  60                  


Leu Phe Val Gly Asn Glu Lys Met Ala Met Gln Asn Leu Asn Asp Arg 
65                  70                  75                  80  


Leu Ala Ser Tyr Leu Glu Lys Val Arg Thr Leu Glu Gln Ser Asn Ser 
                85                  90                  95      


Lys Leu Glu Val Gln Ile Lys Gln Trp Tyr Glu Thr Asn Ala Pro Arg 
            100                 105                 110         


Ala Gly Arg Asp Tyr Ser Ala Tyr Tyr Arg Gln Ile Glu Glu Leu Arg 
        115                 120                 125             


Ser Gln Ile Lys Asp Ala Gln Leu Gln Asn Ala Arg Cys Val Leu Gln 
    130                 135                 140                 


Ile Asp Asn Ala Lys Leu Ala Ala Glu Asp Phe Arg Leu Lys Tyr Glu 
145                 150                 155                 160 


Thr Glu Arg Gly Ile Arg Leu Thr Val Glu Ala Asp Leu Gln Gly Leu 
                165                 170                 175     


Asn Lys Val Phe Asp Asp Leu Thr Leu His Lys Thr Asp Leu Glu Ile 
            180                 185                 190         


Gln Ile Glu Glu Leu Asn Lys Asp Leu Ala Leu Leu Lys Lys Glu His 
        195                 200                 205             


Gln Glu Glu Val Asp Gly Leu His Lys His Leu Gly Asn Thr Val Asn 
    210                 215                 220                 


Val Glu Val Asp Ala Ala Pro Gly Leu Asn Leu Gly Val Ile Met Asn 
225                 230                 235                 240 


Glu Met Arg Gln Lys Tyr Glu Val Met Ala Gln Lys Asn Leu Gln Glu 
                245                 250                 255     


Ala Lys Glu Gln Phe Glu Arg Gln Thr Ala Val Leu Gln Gln Gln Val 
            260                 265                 270         


Thr Val Asn Thr Glu Glu Leu Lys Gly Thr Glu Val Gln Leu Thr Glu 
        275                 280                 285             


Leu Arg Arg Thr Ser Gln Ser Leu Glu Ile Glu Leu Gln Ser His Leu 
    290                 295                 300                 


Ser Met Lys Glu Ser Leu Glu His Thr Leu Glu Glu Thr Lys Ala Arg 
305                 310                 315                 320 


Tyr Ser Ser Gln Leu Ala Asn Leu Gln Ser Leu Leu Ser Ser Leu Glu 
                325                 330                 335     


Ala Gln Leu Met Gln Ile Arg Ser Asn Met Glu Arg Gln Asn Asn Glu 
            340                 345                 350         


Tyr His Ile Leu Leu Asp Ile Lys Thr Arg Leu Glu Gln Glu Ile Ala 
        355                 360                 365             


Thr Tyr Arg Arg Leu Leu Glu Gly Glu Asp Val Lys Thr Thr Glu Tyr 
    370                 375                 380                 


Gln Leu Ser Thr Leu Glu Glu Arg Asp Ile Lys Lys Thr Arg Lys Ile 
385                 390                 395                 400 


Lys Thr Val Val Gln Glu Val Val Asp Gly Lys Val Val Ser Ser Glu 
                405                 410                 415     


Val Lys Glu Val Glu Glu Asn Ile 
            420                 


<210>  4
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly 
1               5                   10                  15      


Pro Arg Ala Phe Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg 
            20                  25                  30          


Ile Ser Ser Ser Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly 
        35                  40                  45              


Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr 
    50                  55                  60                  


Ala Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val 
65                  70                  75                  80  


Asp Pro Asn Ile Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln 
        115                 120                 125             


Gln Lys Thr Ala Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile 
    130                 135                 140                 


Asn Asn Leu Arg Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys 
145                 150                 155                 160 


Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys 
                165                 170                 175     


Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu 
            180                 185                 190         


Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val 
        195                 200                 205             


Glu Leu Glu Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu 
    210                 215                 220                 


Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser 
225                 230                 235                 240 


Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met 
                245                 250                 255     


Asp Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn 
            260                 265                 270         


Arg Ser Arg Ala Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu 
        275                 280                 285             


Leu Gln Ser Leu Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys 
    290                 295                 300                 


Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu 
305                 310                 315                 320 


Ile Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala 
                325                 330                 335     


Asp Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys 
            340                 345                 350         


Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala 
        355                 360                 365             


Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu 
    370                 375                 380                 


Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser 
385                 390                 395                 400 


Arg Leu Glu Ser Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr 
                405                 410                 415     


Ser Gly Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser 
            420                 425                 430         


Pro Gly Leu Ser Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly 
        435                 440                 445             


Ser Ser Ser Phe Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys 
    450                 455                 460                 


Lys Ile Glu Thr Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val 
465                 470                 475                 480 


Leu Pro Lys 
            


<210>  5
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln Leu 
1               5                   10                  15      


Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn Asn 
            20                  25                  30          


Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg Asn 
        35                  40                  45              


Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr Val 
    50                  55                  60                  


Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu Gln 
65                  70                  75                  80  


Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala Val 
                85                  90                  95      


Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro Met 
            100                 105                 110         


Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn Asn 
        115                 120                 125             


Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val Ser 
    130                 135                 140                 


Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu Gly 
145                 150                 155                 160 


Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp Gly 
                165                 170                 175     


Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala Gln 
            180                 185                 190         


Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His 
        195                 200                 205             


Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu 
    210                 215                 220                 


Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro 
225                 230                 235                 240 


Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro 
                245                 250                 255     


Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg 
            260                 265                 270         


Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala 
        275                 280                 285             


Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys 
    290                 295                 300                 


Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe 
305                 310                 315                 320 


Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn 
                325                 330                 335     


Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg 
            340                 345                 350         


Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp 
        355                 360                 365             


Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala 
    370                 375                 380                 


Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile 
385                 390                 395                 400 


Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val 
                405                 410                 415     


Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser 
            420                 425                 430         


Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn 
        435                 440                 445             


Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys 
    450                 455                 460                 


Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val 
465                 470                 475                 480 


Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg 
                485                 490                 495     


Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp 
            500                 505                 510         


Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser 
        515                 520                 525             


Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile 
    530                 535                 540                 


Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr 
545                 550                 555                 560 


Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly 
                565                 570                 575     


Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys 
            580                 585                 590         


His Leu Cys His Pro Asn Cys Thr Tyr Gly 
        595                 600         


<210>  6
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys 
1               5                   10                  15      


Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile 
            20                  25                  30          


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
        35                  40                  45              


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
    50                  55                  60                  


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
65                  70                  75                  80  


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
                85                  90                  95      


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
            100                 105                 110         


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
        115                 120                 125             


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
    130                 135                 140                 


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
145                 150                 155                 160 


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
                165                 170                 175     


<210>  7
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu 
1               5                   10                  15      


Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro 
            20                  25                  30          


Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile 
        35                  40                  45              


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp 
    50                  55                  60                  


Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu 
65                  70                  75                  80  


Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                85                  90                  95      


Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly 
            100                 105                 110         


Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe 
        115                 120                 125             


Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser 
    130                 135                 140                 


Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr 
145                 150                 155                 160 


Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                165                 170                 175     


Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            180                 185                 190         


Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys 
        195                 200                 205             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr 
    210                 215                 220                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
225                 230                 235                 240 


Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile 
                245                 250                 255     


Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            260                 265                 270         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala 
        275                 280                 285             


Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met 
    290                 295                 300                 


Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met 
305                 310                 315                 320 


His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp 
                325                 330                 335     


Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro 
            340                 345                 350         


Gln Gln Gly 
        355 


<210>  8
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln Leu 
1               5                   10                  15      


Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn Asn 
            20                  25                  30          


Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg Asn 
        35                  40                  45              


Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr Val 
    50                  55                  60                  


Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu Gln 
65                  70                  75                  80  


Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala Val 
                85                  90                  95      


Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro Met 
            100                 105                 110         


Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn Asn 
        115                 120                 125             


Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val Ser 
    130                 135                 140                 


Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu Gly 
145                 150                 155                 160 


Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp Gly 
                165                 170                 175     


Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala Gln 
            180                 185                 190         


Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His 
        195                 200                 205             


Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu 
    210                 215                 220                 


Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro 
225                 230                 235                 240 


Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro 
                245                 250                 255     


Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg 
            260                 265                 270         


Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala 
        275                 280                 285             


Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys 
    290                 295                 300                 


Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe 
305                 310                 315                 320 


Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn 
                325                 330                 335     


Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg 
            340                 345                 350         


Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp 
        355                 360                 365             


Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
    370                 375             


<210>  9
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu 
1               5                   10                  15      


Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro 
            20                  25                  30          


Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile 
        35                  40                  45              


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp 
    50                  55                  60                  


Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu 
65                  70                  75                  80  


Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                85                  90                  95      


Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly 
            100                 105                 110         


Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe 
        115                 120                 125             


Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser 
    130                 135                 140                 


Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr 
145                 150                 155                 160 


Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                165                 170                 175     


Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            180                 185                 190         


Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys 
        195                 200                 205             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr 
    210                 215                 220                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
225                 230                 235                 240 


Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile 
                245                 250                 255     


Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            260                 265                 270         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala 
        275                 280                 285             


Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met 
    290                 295                 300                 


Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met 
305                 310                 315                 320 


His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp 
                325                 330                 335     


Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro 
            340                 345                 350         


Gln Gln 
        


<210>  10
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Ser Cys 
1               5                   10                  15      


Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val 
            20                  25                  30          


Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly 
        35                  40                  45              


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
    50                  55                  60                  


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
65                  70                  75                  80  


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
                85                  90                  95      


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
            100                 105                 110         


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
        115                 120                 125             


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
    130                 135                 140                 


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
145                 150                 155                 160 


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
                165                 170                 175     


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
            180                 185                 190         


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
        195                 200                 205             


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
    210                 215                 220                 


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
225                 230                 235                 240 


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
                245                 250                 255     


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
            260                 265                 270         


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
        275                 280                 285             


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
    290                 295                 300                 


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
305                 310                 315                 320 


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly 
                325                 330                 335     


<210>  11
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Gln Leu Leu Val Leu Lys Ile Glu Asp Pro Gly Cys Phe Trp 
1               5                   10                  15      


Val Ile Ile Lys Gly Cys Ser Pro Phe Leu Asp His Asp Val Asp Tyr 
            20                  25                  30          


Gln Lys Leu Asn Ser Ala Met Asn Asp Phe Tyr Asn Ser Thr Cys Gln 
        35                  40                  45              


Asp Ile Glu Ile Lys Pro Leu Thr Leu Glu Glu Gly Gln Val Cys Val 
    50                  55                  60                  


Val Tyr Cys Glu Glu Leu Lys Cys Trp Cys Arg Ala Ile Val Lys Ser 
65                  70                  75                  80  


Ile Thr Ser Ser Ala Asp Gln Tyr Leu Ala Glu Cys Phe Leu Val Asp 
                85                  90                  95      


Phe Ala Lys Asn Ile Pro Val Lys Ser Lys Asn Ile Arg Val Val Val 
            100                 105                 110         


Glu Ser Phe Met Gln Leu Pro Tyr Arg Ala Lys Lys Phe Ser Leu Tyr 
        115                 120                 125             


Cys Thr Lys Pro Val Thr Leu His Ile Asp Phe Cys Arg Asp Ser Thr 
    130                 135                 140                 


Asp Ile Val Pro Ala Lys Lys Trp Asp Asn Ala Ala Ile Gln Tyr Phe 
145                 150                 155                 160 


Gln Asn Leu Leu Lys Ala Thr Thr Gln Val Glu Ala Arg Leu Cys Ala 
                165                 170                 175     


Val Glu Glu Asp Thr Phe Glu Val Tyr Leu Tyr Val Thr Ile Lys Asp 
            180                 185                 190         


Glu Lys Val Cys Val Asn Asp Asp Leu Val Ala Lys Asn Tyr Ala Cys 
        195                 200                 205             


Tyr Met Ser Pro Thr Lys Asn Lys Asn Leu Asp Tyr Leu Glu Lys Pro 
    210                 215                 220                 


Arg Leu Asn Ile Lys Ser Ala Pro Ser Phe Asn Lys Leu Asn Pro Ala 
225                 230                 235                 240 


Leu Thr Leu Trp Pro Met Phe Leu Gln Gly Lys Asp Val Gln Gly Met 
                245                 250                 255     


Glu Asp Ser His Gly Val Asn Phe Pro Ala Gln Ser Leu Gln His Thr 
            260                 265                 270         


Trp Cys Lys Gly Ile Val Gly Asp Leu Arg Pro Thr Ala Thr Ala Gln 
        275                 280                 285             


Asp Lys Ala Val Lys Cys Asn Met Asp Ser Leu Arg Asp Ser Pro Lys 
    290                 295                 300                 


Asp Lys Ser Glu Lys Lys His His Cys Ile Ser Leu Lys Asp Thr Asn 
305                 310                 315                 320 


Lys Arg Val Glu Ser Ser Val Tyr Trp Pro Ala Lys Arg Gly Ile Thr 
                325                 330                 335     


Ile Tyr Ala Asp Pro Asp Val Pro Glu Ala Ser Ala Leu Ser Gln Lys 
            340                 345                 350         


Ser Asn Glu Lys Pro Leu Arg Leu Thr Glu Lys Lys Glu Tyr Asp Glu 
        355                 360                 365             


Lys Asn Ser Cys Val Lys 
    370                 


<210>  12
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Met Ile Ile Ser Thr Met Glu Pro Gln Val Ser Asn Gly Pro 
1               5                   10                  15      


Thr Ser Asn Thr Ser Asn Gly Pro Ser Ser Asn Asn Arg Asn Cys Pro 
            20                  25                  30          


Ser Pro Met Gln Thr Gly Ala Thr Thr Asp Asp Ser Lys Thr Asn Leu 
        35                  40                  45              


Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln Glu Glu Phe Arg Ser 
    50                  55                  60                  


Leu Phe Gly Ser Ile Gly Glu Ile Glu Ser Cys Lys Leu Val Arg Asp 
65                  70                  75                  80  


Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe Val Asn Tyr Ile Asp 
                85                  90                  95      


Pro Lys Asp Ala Glu Lys Ala Ile Asn Thr Leu Asn Gly Leu Arg Leu 
            100                 105                 110         


Gln Thr Lys Thr Ile Lys Val Ser Tyr Ala Arg Pro Ser Ser Ala Ser 
        115                 120                 125             


Ile Arg Asp Ala Asn Leu Tyr Val Ser Gly Leu Pro Lys Thr Met Thr 
    130                 135                 140                 


Gln Lys Glu Leu Glu Gln Leu Phe Ser Gln Tyr Gly Arg Ile Ile Thr 
145                 150                 155                 160 


Ser Arg Ile Leu Val Gly Gln Val Thr Gly Val Ser Arg Gly Val Gly 
                165                 170                 175     


Phe Ile Arg Phe Asp Lys Arg Ile Glu Ala Glu Glu Ala Ile Lys Gly 
            180                 185                 190         


Leu Asn Gly Gln Lys Pro Ser Gly Ala Thr Glu Pro Ile Thr Val Lys 
        195                 200                 205             


Phe Ala Asn Asn Pro Ser Gln Lys Ser Ser Gln Ala Leu Leu Ser Gln 
    210                 215                 220                 


Leu Tyr Gln Ser Pro Asn Arg Arg Tyr Pro Gly Pro Leu His His Gln 
225                 230                 235                 240 


Ala Gln Arg Phe Arg Leu Asp Asn Leu Leu Asn Met Ala Tyr Gly Val 
                245                 250                 255     


Lys Arg Phe Ser Pro Ile Thr Ile Asp Gly Met Thr Ser Leu Val Gly 
            260                 265                 270         


Met Asn Ile Pro Gly His Thr Gly Thr Gly Trp Cys Ile Phe Val Tyr 
        275                 280                 285             


Asn Leu Ser Pro Asp Ser Asp Glu Ser Val Leu Trp Gln Leu Phe Gly 
    290                 295                 300                 


Pro Phe Gly Ala Val Asn Asn Val Lys Val Ile Arg Asp Phe Asn Thr 
305                 310                 315                 320 


Asn Lys Cys Lys Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu 
                325                 330                 335     


Ala Ala Met Ala Ile Thr Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg 
            340                 345                 350         


Val Leu Gln Val Ser Phe Lys Thr Asn Lys Ala His Lys Ser 
        355                 360                 365     


<210>  13
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly His Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  14
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Ser Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Val 
1               5                   10                  15      


Glu Ala Gln Glu Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Val Ser Ser Ser Ser Pro Leu Val Pro 
        35                  40                  45              


Gly Thr Leu Glu Glu Val Pro Ala Ala Glu Ser Ala Gly Pro Pro Gln 
    50                  55                  60                  


Ser Pro Gln Gly Ala Ser Ala Leu Pro Thr Thr Ile Ser Phe Thr Cys 
65                  70                  75                  80  


Trp Arg Gln Pro Asn Glu Gly Ser Ser Ser Gln Glu Glu Glu Gly Pro 
                85                  90                  95      


Ser Thr Ser Pro Asp Ala Glu Ser Leu Phe Arg Glu Ala Leu Ser Asn 
            100                 105                 110         


Lys Val Asp Glu Leu Ala His Phe Leu Leu Arg Lys Tyr Arg Ala Lys 
        115                 120                 125             


Glu Leu Val Thr Lys Ala Glu Met Leu Glu Arg Val Ile Lys Asn Tyr 
    130                 135                 140                 


Lys Arg Cys Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Ser Leu Lys 
145                 150                 155                 160 


Met Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Ser Asn Thr 
                165                 170                 175     


Tyr Thr Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly 
            180                 185                 190         


Asn Asn Gln Ile Phe Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Gly 
        195                 200                 205             


Thr Ile Ala Met Glu Gly Asp Ser Ala Ser Glu Glu Glu Ile Trp Glu 
    210                 215                 220                 


Glu Leu Gly Val Met Gly Val Tyr Asp Gly Arg Glu His Thr Val Tyr 
225                 230                 235                 240 


Gly Glu Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr 
                245                 250                 255     


Leu Glu Tyr Arg Gln Val Pro Gly Ser Asn Pro Ala Arg Tyr Glu Phe 
            260                 265                 270         


Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu 
        275                 280                 285             


Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ala Tyr Pro Ser 
    290                 295                 300                 


Leu Arg Glu Ala Ala Leu Leu Glu Glu Glu Glu Gly Val 
305                 310                 315         


<210>  15
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  16
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
1               5                   10                  15      


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
            20                  25                  30          


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
        35                  40                  45              


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
    50                  55                  60                  


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
65                  70                  75                  80  


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
                85                  90                  95      


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
            100                 105             


<210>  17
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  18
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser 
                85                  90                  95  


<210>  19
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Pro Ala Val Thr Ala 
1               5                   10                  15      


Asp Asp Leu Arg Gln Leu Phe Gly Asp Arg Lys Leu Pro Leu Ala Gly 
            20                  25                  30          


Gln Val Leu Leu Lys Ser Gly Tyr Ala Phe Val Asp Tyr Pro Asp Gln 
        35                  40                  45              


Asn Trp Ala Ile Arg Ala Ile Glu Thr Leu Ser Gly Lys Val Glu Leu 
    50                  55                  60                  


His Gly Lys Ile Met Glu Val Asp Tyr Ser Val Ser Lys Lys Leu Arg 
65                  70                  75                  80  


Ser Arg Lys Ile Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu 
                85                  90                  95      


Val Leu Asp Gly Leu Leu Ala Gln Tyr Gly Thr Val Glu Asn Val Glu 
            100                 105                 110         


Gln Val Asn Thr Asp Thr Glu Thr Ala Val Val Asn Val Thr Tyr Ala 
        115                 120                 125             


Thr Arg Glu Glu Ala Lys Ile Ala Met Glu Lys Leu Ser Gly His Gln 
    130                 135                 140                 


Phe Glu Asn Tyr Ser Phe Lys Ile Ser Tyr Ile Pro Asp Glu Glu Val 
145                 150                 155                 160 


Ser Ser Pro Ser Pro Pro Gln Arg Ala Gln Arg Gly Asp His Ser Ser 
                165                 170                 175     


Arg Glu Gln Gly His Ala Pro Gly Gly Thr Ser Gln Ala Arg Gln Ile 
            180                 185                 190         


Asp Phe Pro Leu Arg Ile Leu Val Pro Thr Gln Phe Val Gly Ala Ile 
        195                 200                 205             


Ile Gly Lys Glu Gly Leu Thr Ile Lys Asn Ile Thr Lys Gln Thr Gln 
    210                 215                 220                 


Ser Arg Val Asp Ile His Arg Lys Glu Asn Ser Gly Ala Ala Glu Lys 
225                 230                 235                 240 


Pro Val Thr Ile His Ala Thr Pro Glu Gly Thr Ser Glu Ala Cys Arg 
                245                 250                 255     


Met Ile Leu Glu Ile Met Gln Lys Glu Ala Asp Glu Thr Lys Leu Ala 
            260                 265                 270         


Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Gly Leu Val Gly Arg 
        275                 280                 285             


Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu His Glu Thr 
    290                 295                 300                 


Gly Thr Lys Ile Thr Ile Ser Ser Leu Gln Asp Leu Ser Ile Tyr Asn 
305                 310                 315                 320 


Pro Glu Arg Thr Ile Thr Val Lys Gly Thr Val Glu Ala Cys Ala Ser 
                325                 330                 335     


Ala Glu Ile Glu Ile Met Lys Lys Leu Arg Glu Ala Phe Glu Asn Asp 
            340                 345                 350         


Met Leu Ala Val Asn Gln Gln Ala Asn Leu Ile Pro Gly Leu Asn Leu 
        355                 360                 365             


Ser Ala Leu Gly Ile Phe Ser Thr Gly Leu Ser Val Leu Ser Pro Pro 
    370                 375                 380                 


Ala Gly Pro Arg Gly Ala Pro Pro Ala Ala Pro Tyr His Pro Phe Thr 
385                 390                 395                 400 


Thr His Ser Gly Tyr Phe Ser Ser Leu Tyr Pro His His Gln Phe Gly 
                405                 410                 415     


Pro Phe Pro His His His Ser Tyr Pro Glu Gln Glu Ile Val Asn Leu 
            420                 425                 430         


Phe Ile Pro Thr Gln Ala Val Gly Ala Ile Ile Gly Lys Lys Gly Ala 
        435                 440                 445             


His Ile Lys Gln Leu Ala Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala 
    450                 455                 460                 


Pro Ala Glu Gly Pro Asp Val Ser Glu Arg Met Val Ile Ile Thr Gly 
465                 470                 475                 480 


Pro Pro Glu Ala Gln Phe Lys Ala Gln Gly Arg Ile Phe Gly Lys Leu 
                485                 490                 495     


Lys Glu Glu Asn Phe Phe Asn Pro Lys Glu Glu Val Lys Leu Glu Ala 
            500                 505                 510         


His Ile Arg Val Pro Ser Ser Thr Ala Gly Arg Val Ile Gly Lys Gly 
        515                 520                 525             


Gly Lys Thr Val Asn Glu Leu Gln Asn Leu Thr Ser Ala Glu Val Ile 
    530                 535                 540                 


Val Pro Arg Asp Gln Thr Pro Asp Glu Asn Glu Glu Val Ile Val Arg 
545                 550                 555                 560 


Ile Ile Gly His Phe Phe Ala Ser Gln Thr Ala Gln Arg Lys Ile Arg 
                565                 570                 575     


Glu Ile Val Gln Gln Val Lys Gln Gln Glu Gln Lys Tyr Pro Gln Gly 
            580                 585                 590         


Val Ala Ser Gln Arg Ser Lys 
        595                 


<210>  20
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  21
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asn Gly Asp Asp Thr Phe Ala Lys Arg Pro Arg Asp Asp Ala Lys 
1               5                   10                  15      


Ala Ser Glu Lys Arg Ser Lys Ala Phe Asp Asp Ile Ala Thr Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Lys Lys Met Lys Tyr Ser Glu Lys Ile Ser Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Asn Tyr Lys Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Cys Asn Lys Gln Ala Thr Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp His Asn Arg Arg Ile Gln Val Glu His 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu His Arg Ile Ile Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Asp Glu Asn Asp Ser Lys Gly Val Ser Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu His Pro Pro Gly Lys 
    130                 135                 140                 


Ala Asn Ile Ser Glu Lys Ile Asn Lys Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  22
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Leu Lys Val Thr Val Asn Gly Thr Ala Tyr Asp Val Asp Val 
1               5                   10                  15      


Asp Val Asp Lys Ser His Glu Asn Pro Met Gly Thr Ile Leu Phe Gly 
            20                  25                  30          


Gly Gly Thr Gly Gly Ala Pro Ala Pro Ala Ala Gly Gly Ala Gly Ala 
        35                  40                  45              


Gly Lys Ala Gly Glu Gly Glu Ile Pro Ala Pro Leu Ala Gly Thr Val 
    50                  55                  60                  


Ser Lys Ile Leu Val Lys Glu Gly Asp Thr Val Lys Ala Gly Gln Thr 
65                  70                  75                  80  


Val Leu Val Leu Glu Ala Met Lys Met Glu Thr Glu Ile Asn Ala Pro 
                85                  90                  95      


Thr Asp Gly Lys Val Glu Lys Val Leu Val Lys Glu Arg Asp Ala Val 
            100                 105                 110         


Gln Gly Gly Gln Gly Leu Ile Lys Ile Gly Asp Leu Glu Leu Ile Glu 
        115                 120                 125             


Gly 
    


<210>  23
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr 
1               5                   10                  15      


Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu 
            20                  25                  30          


Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn 
        35                  40                  45              


Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr 
    50                  55                  60                  


Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro 
65                  70                  75                  80  


Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro 
                85                  90                  95      


Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            100                 105                 110         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        115                 120                 125             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala 
    130                 135                 140                 


His Ser Ser His Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His 
145                 150                 155                 160 


Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp Ser Asp 
                165                 170             


<210>  24
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  25
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Glu Asn Ala Ala Pro Ser 
1               5                   10                  15      


Asp Leu Glu Ser Ile Phe Lys Asp Ala Lys Ile Pro Val Ser Gly Pro 
            20                  25                  30          


Phe Leu Val Lys Thr Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu Ser 
        35                  40                  45              


Trp Ala Leu Lys Ala Ile Glu Ala Leu Ser Gly Lys Ile Glu Leu His 
    50                  55                  60                  


Gly Lys Pro Ile Glu Val Glu His Ser Val Pro Lys Arg Gln Arg Ile 
65                  70                  75                  80  


Arg Lys Leu Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Val Gln Tyr Gly Val Val Glu Ser Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Asp Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Ser 
        115                 120                 125             


Lys Asp Gln Ala Arg Gln Ala Leu Asp Lys Leu Asn Gly Phe Gln Leu 
    130                 135                 140                 


Glu Asn Phe Thr Leu Lys Val Ala Tyr Ile Pro Asp Glu Met Ala Ala 
145                 150                 155                 160 


Gln Gln Asn Pro Leu Gln Gln Pro Arg Gly Arg Arg Gly Leu Gly Gln 
                165                 170                 175     


Arg Gly Ser Ser Arg Gln Gly Ser Pro Gly Ser Val Ser Lys Gln Lys 
            180                 185                 190         


Pro Cys Asp Leu Pro Leu Arg Leu Leu Val Pro Thr Gln Phe Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ser Ile Thr Ile Leu Ser Thr Pro Glu Gly Thr Ser Ala Ala 
                245                 250                 255     


Cys Lys Ser Ile Leu Glu Ile Met His Lys Glu Ala Gln Asp Ile Lys 
            260                 265                 270         


Phe Thr Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu Gln 
    290                 295                 300                 


Asp Thr Asp Thr Lys Ile Thr Ile Ser Pro Leu Gln Glu Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Asn Val Glu Thr Cys 
                325                 330                 335     


Ala Lys Ala Glu Glu Glu Ile Met Lys Lys Ile Arg Glu Ser Tyr Glu 
            340                 345                 350         


Asn Asp Ile Ala Ser Met Asn Leu Gln Ala His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Asn Ala Leu Gly Leu Phe Pro Pro Thr Ser Gly Met Pro Pro 
    370                 375                 380                 


Pro Thr Ser Gly Pro Pro Ser Ala Met Thr Pro Pro Tyr Pro Gln Phe 
385                 390                 395                 400 


Glu Gln Ser Glu Thr Glu Thr Val His Leu Phe Ile Pro Ala Leu Ser 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Gln Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala Pro Ala Glu Ala Pro Asp 
        435                 440                 445             


Ala Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Ile Lys Glu Glu Asn Phe Val 
465                 470                 475                 480 


Ser Pro Lys Glu Glu Val Lys Leu Glu Ala His Ile Arg Val Pro Ser 
                485                 490                 495     


Phe Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Ser Ser Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Val Val Lys Ile Thr Gly His Phe Tyr 
    530                 535                 540                 


Ala Cys Gln Val Ala Gln Arg Lys Ile Gln Glu Ile Leu Thr Gln Val 
545                 550                 555                 560 


Lys Gln His Gln Gln Gln Lys Ala Leu Gln Ser Gly Pro Pro Gln Ser 
                565                 570                 575     


Arg Arg Lys 
            


<210>  26
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  26

Thr Ser Pro Pro Trp Gly Leu Gly Pro Gly Ala Gly Asp Pro Ala Pro 
1               5                   10                  15      


Gly Ile Gly Pro Pro Glu Pro Trp Pro Gly Gly Cys Thr Gly Asp Glu 
            20                  25                  30          


Ala Glu Ser Arg Gly His Ser Lys Gly Trp Gly Arg Asn Tyr Ala Ser 
        35                  40                  45              


Ile Ile Arg Arg Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Arg 
    50                  55                  60                  


Leu Glu Arg Ala Val Ser Asp Arg Leu Ala Pro Gly Ala Pro Arg Gly 
65                  70                  75                  80  


Asn Pro Pro Lys Ala Ser Ala Ala Pro Asp Cys Thr Pro Ser Leu Glu 
                85                  90                  95      


Ala Gly Asn Pro Ala Pro Ala Ala Pro Cys Pro Leu Gly Glu Pro Lys 
            100                 105                 110         


Thr Gln Ala Cys Ser Gly Ser Glu Ser Pro Ser Asp Ser Glu Asn Glu 
        115                 120                 125             


Glu Ile Asp Val Val Thr Val Glu Lys Arg Gln Ser Leu Gly Ile Arg 
    130                 135                 140                 


Lys Pro Val Thr Ile Thr Val Arg Ala Asp Pro Leu Asp Pro Cys Met 
145                 150                 155                 160 


Lys His Phe His Ile Ser Ile His Gln Gln Gln His Asn Tyr Ala Ala 
                165                 170                 175     


Arg Phe Pro Pro Glu Ser Cys Ser Gln Glu Glu Ala Ser Glu Arg Gly 
            180                 185                 190         


Pro Gln Glu Glu 
        195     


