                         SEQUENCE LISTING

<110>  Danmarks Tekniske Universitet
 
<120>  Engineered probiotic bacteria for prebiotic-responsive control of
        colonization

<130>  P2794PC00

<150>  EP 20186080.6
<151>  2020-07-15

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  80
<212>  DNA
<213>  synthetic


<220>
<221>  promoter
<222>  (1)..(80)
<223>  Tet promoter

<400>  1
ttgacagctt atcatcgata agctttaatg cggtagttta tcacagttaa attgctaacg       60

cagtcaggca cagctttaat                                                   80


<210>  2
<211>  30
<212>  DNA
<213>  synthetic


<220>
<221>  promoter
<222>  (1)..(30)
<223>  pTac promoter

<400>  2
ttgacaatta atcatccggc tcgtataatg                                        30


<210>  3
<211>  36
<212>  DNA
<213>  synthetic


<220>
<221>  promoter
<222>  (1)..(36)
<223>  pMSKKL7 promoter

<400>  3
tgcttgactc gtcgttcctc ctacgtgtat aattgg                                 36


<210>  4
<211>  74
<212>  DNA
<213>  synthetic


<220>
<221>  promoter
<222>  (1)..(74)
<223>  pfnrS pormoter

<400>  4
tctgtataca aaaacgccgc aaagtttgag cgaagtcaat aaactctcta cccattcagg       60

gcaatatctc tctt                                                         74


<210>  5
<211>  1447
<212>  DNA
<213>  E. coli


<220>
<221>  CDS
<222>  (53)..(1447)
<223>  gene encoding RafY glycoporin

<400>  5
atcatgagat ttggaaagcg tagggtctct tttatttcag ggaacgtaaa ta atg aaa       58
                                                          Met Lys         
                                                          1               

aaa tcg aca tta tct tta gcc atc ggt tta tta ttg gca tgt agt acc        106
Lys Ser Thr Leu Ser Leu Ala Ile Gly Leu Leu Leu Ala Cys Ser Thr           
        5                   10                  15                        

gga atg gca aaa aca cag cat tta acg ctg gaa caa cgc atg gca ttg        154
Gly Met Ala Lys Thr Gln His Leu Thr Leu Glu Gln Arg Met Ala Leu           
    20                  25                  30                            

ctg gaa gaa cgc ctg gaa gcg gca gaa atg cgg gca gca aaa gca gag        202
Leu Glu Glu Arg Leu Glu Ala Ala Glu Met Arg Ala Ala Lys Ala Glu           
35                  40                  45                  50            

agc cag gtt aaa cag ctg cag aca caa caa gcc gct gag atc cgc gaa        250
Ser Gln Val Lys Gln Leu Gln Thr Gln Gln Ala Ala Glu Ile Arg Glu           
                55                  60                  65                

att aag gct gcc cag ggc aat acg ccg gta aat gga cag gca acg gcg        298
Ile Lys Ala Ala Gln Gly Asn Thr Pro Val Asn Gly Gln Ala Thr Ala           
            70                  75                  80                    

gaa tct gca aag aaa aat tcc acc tca cct aat ctt ttg ctc tca ggt        346
Glu Ser Ala Lys Lys Asn Ser Thr Ser Pro Asn Leu Leu Leu Ser Gly           
        85                  90                  95                        

tat ggc gat tta aaa atc tac ggc gac gta gaa ttt aat atg gat gcg        394
Tyr Gly Asp Leu Lys Ile Tyr Gly Asp Val Glu Phe Asn Met Asp Ala           
    100                 105                 110                           

gaa agt aat cat ggc ctt ctg gca atg acc aac gct gat gtg aat agc        442
Glu Ser Asn His Gly Leu Leu Ala Met Thr Asn Ala Asp Val Asn Ser           
115                 120                 125                 130           

gat ccc act aat gaa cag tgg aat ctc aat ggt cgt att ctg tta ggt        490
Asp Pro Thr Asn Glu Gln Trp Asn Leu Asn Gly Arg Ile Leu Leu Gly           
                135                 140                 145               

ttt gat ggt atg cga aaa ctg gat aat ggt tat ttc gcc ggg ttc tcc        538
Phe Asp Gly Met Arg Lys Leu Asp Asn Gly Tyr Phe Ala Gly Phe Ser           
            150                 155                 160                   

gca caa ccg ctg ggg gat atg cac ggc tca gta aat atc gat gat gcg        586
Ala Gln Pro Leu Gly Asp Met His Gly Ser Val Asn Ile Asp Asp Ala           
        165                 170                 175                       

gtt ttc ttc ttt ggc aaa gaa aac gac tgg aag gtc aaa gta ggc cgt        634
Val Phe Phe Phe Gly Lys Glu Asn Asp Trp Lys Val Lys Val Gly Arg           
    180                 185                 190                           

ttt gaa gcc tac gat atg ttc cca ctg aat cag gat acc ttt gtt gaa        682
Phe Glu Ala Tyr Asp Met Phe Pro Leu Asn Gln Asp Thr Phe Val Glu           
195                 200                 205                 210           

cat tcc ggt aat act gcg aac gat ctt tat gac gat ggc agc ggt tat        730
His Ser Gly Asn Thr Ala Asn Asp Leu Tyr Asp Asp Gly Ser Gly Tyr           
                215                 220                 225               

atc tat atg atg aaa gag ggc cgc ggg cgt tct aac gct ggc ggt aat        778
Ile Tyr Met Met Lys Glu Gly Arg Gly Arg Ser Asn Ala Gly Gly Asn           
            230                 235                 240                   

ttc ctc gtc agc aaa caa ctc gat aac tgg tat ttt gaa tta aac acg        826
Phe Leu Val Ser Lys Gln Leu Asp Asn Trp Tyr Phe Glu Leu Asn Thr           
        245                 250                 255                       

tta ctg gaa gac gga aca tct tta tat aac gac ggt aat tat cat gga        874
Leu Leu Glu Asp Gly Thr Ser Leu Tyr Asn Asp Gly Asn Tyr His Gly           
    260                 265                 270                           

cgc gat atg gaa cag cag aaa aat gtt gct tat ctg cgt ccg gta att        922
Arg Asp Met Glu Gln Gln Lys Asn Val Ala Tyr Leu Arg Pro Val Ile           
275                 280                 285                 290           

gcc tgg tcg ccg acg gaa gaa ttc acc gtt tcc gca gcg atg gaa gcg        970
Ala Trp Ser Pro Thr Glu Glu Phe Thr Val Ser Ala Ala Met Glu Ala           
                295                 300                 305               

aat gtg gta aat aat gct tat ggt tat acc gat agc aag ggt aat ttt       1018
Asn Val Val Asn Asn Ala Tyr Gly Tyr Thr Asp Ser Lys Gly Asn Phe           
            310                 315                 320                   

gtc gat cag tcc gat cgt acc ggt tat ggc atg agc atg acc tgg aat       1066
Val Asp Gln Ser Asp Arg Thr Gly Tyr Gly Met Ser Met Thr Trp Asn           
        325                 330                 335                       

ggc ctg aaa acc gat ccg gaa aat ggc atc gtg gtt aat ctt aat acc       1114
Gly Leu Lys Thr Asp Pro Glu Asn Gly Ile Val Val Asn Leu Asn Thr           
    340                 345                 350                           

gcc tat tta gat gct aat aat gaa aaa gat ttc acc gct ggg att aac       1162
Ala Tyr Leu Asp Ala Asn Asn Glu Lys Asp Phe Thr Ala Gly Ile Asn           
355                 360                 365                 370           

gcg ctg tgg aaa cgt ttc gag ctg ggt tat atc tac gca cat aat aag       1210
Ala Leu Trp Lys Arg Phe Glu Leu Gly Tyr Ile Tyr Ala His Asn Lys           
                375                 380                 385               

att gat gaa ttt agt ggc gtg gtt tgt gat aac gat tgc tgg att gat       1258
Ile Asp Glu Phe Ser Gly Val Val Cys Asp Asn Asp Cys Trp Ile Asp           
            390                 395                 400                   

gat gaa gga aca tac aac att cac acc att cat gcg tct tat cag ttc       1306
Asp Glu Gly Thr Tyr Asn Ile His Thr Ile His Ala Ser Tyr Gln Phe           
        405                 410                 415                       

gct aat gtg atg gat atg gag aac ttt aat att tac ctc ggc acg tat       1354
Ala Asn Val Met Asp Met Glu Asn Phe Asn Ile Tyr Leu Gly Thr Tyr           
    420                 425                 430                           

tac tcc att ctg gat agc gac ggc gat aag ata cac ggc gac gat agt       1402
Tyr Ser Ile Leu Asp Ser Asp Gly Asp Lys Ile His Gly Asp Asp Ser           
435                 440                 445                 450           

gat gac cgt tac ggc gca cgc gtt cgc ttt aaa tac ttc ttc tga           1447
Asp Asp Arg Tyr Gly Ala Arg Val Arg Phe Lys Tyr Phe Phe                   
                455                 460                                   


<210>  6
<211>  464
<212>  PRT
<213>  E. coli

<400>  6

Met Lys Lys Ser Thr Leu Ser Leu Ala Ile Gly Leu Leu Leu Ala Cys 
1               5                   10                  15      


Ser Thr Gly Met Ala Lys Thr Gln His Leu Thr Leu Glu Gln Arg Met 
            20                  25                  30          


Ala Leu Leu Glu Glu Arg Leu Glu Ala Ala Glu Met Arg Ala Ala Lys 
        35                  40                  45              


Ala Glu Ser Gln Val Lys Gln Leu Gln Thr Gln Gln Ala Ala Glu Ile 
    50                  55                  60                  


Arg Glu Ile Lys Ala Ala Gln Gly Asn Thr Pro Val Asn Gly Gln Ala 
65                  70                  75                  80  


Thr Ala Glu Ser Ala Lys Lys Asn Ser Thr Ser Pro Asn Leu Leu Leu 
                85                  90                  95      


Ser Gly Tyr Gly Asp Leu Lys Ile Tyr Gly Asp Val Glu Phe Asn Met 
            100                 105                 110         


Asp Ala Glu Ser Asn His Gly Leu Leu Ala Met Thr Asn Ala Asp Val 
        115                 120                 125             


Asn Ser Asp Pro Thr Asn Glu Gln Trp Asn Leu Asn Gly Arg Ile Leu 
    130                 135                 140                 


Leu Gly Phe Asp Gly Met Arg Lys Leu Asp Asn Gly Tyr Phe Ala Gly 
145                 150                 155                 160 


Phe Ser Ala Gln Pro Leu Gly Asp Met His Gly Ser Val Asn Ile Asp 
                165                 170                 175     


Asp Ala Val Phe Phe Phe Gly Lys Glu Asn Asp Trp Lys Val Lys Val 
            180                 185                 190         


Gly Arg Phe Glu Ala Tyr Asp Met Phe Pro Leu Asn Gln Asp Thr Phe 
        195                 200                 205             


Val Glu His Ser Gly Asn Thr Ala Asn Asp Leu Tyr Asp Asp Gly Ser 
    210                 215                 220                 


Gly Tyr Ile Tyr Met Met Lys Glu Gly Arg Gly Arg Ser Asn Ala Gly 
225                 230                 235                 240 


Gly Asn Phe Leu Val Ser Lys Gln Leu Asp Asn Trp Tyr Phe Glu Leu 
                245                 250                 255     


Asn Thr Leu Leu Glu Asp Gly Thr Ser Leu Tyr Asn Asp Gly Asn Tyr 
            260                 265                 270         


His Gly Arg Asp Met Glu Gln Gln Lys Asn Val Ala Tyr Leu Arg Pro 
        275                 280                 285             


Val Ile Ala Trp Ser Pro Thr Glu Glu Phe Thr Val Ser Ala Ala Met 
    290                 295                 300                 


Glu Ala Asn Val Val Asn Asn Ala Tyr Gly Tyr Thr Asp Ser Lys Gly 
305                 310                 315                 320 


Asn Phe Val Asp Gln Ser Asp Arg Thr Gly Tyr Gly Met Ser Met Thr 
                325                 330                 335     


Trp Asn Gly Leu Lys Thr Asp Pro Glu Asn Gly Ile Val Val Asn Leu 
            340                 345                 350         


Asn Thr Ala Tyr Leu Asp Ala Asn Asn Glu Lys Asp Phe Thr Ala Gly 
        355                 360                 365             


Ile Asn Ala Leu Trp Lys Arg Phe Glu Leu Gly Tyr Ile Tyr Ala His 
    370                 375                 380                 


Asn Lys Ile Asp Glu Phe Ser Gly Val Val Cys Asp Asn Asp Cys Trp 
385                 390                 395                 400 


Ile Asp Asp Glu Gly Thr Tyr Asn Ile His Thr Ile His Ala Ser Tyr 
                405                 410                 415     


Gln Phe Ala Asn Val Met Asp Met Glu Asn Phe Asn Ile Tyr Leu Gly 
            420                 425                 430         


Thr Tyr Tyr Ser Ile Leu Asp Ser Asp Gly Asp Lys Ile His Gly Asp 
        435                 440                 445             


Asp Ser Asp Asp Arg Tyr Gly Ala Arg Val Arg Phe Lys Tyr Phe Phe 
    450                 455                 460                 


<210>  7
<211>  1518
<212>  DNA
<213>  E. coli


<220>
<221>  CDS
<222>  (1)..(1518)
<223>  gene encoding ScrY sucrose porin

<400>  7
atg tat aaa aaa aca act ttg gca atg tta att gct ttg ctg acc ggt         48
Met Tyr Lys Lys Thr Thr Leu Ala Met Leu Ile Ala Leu Leu Thr Gly           
1               5                   10                  15                

gct aca acg gta cat gcg caa acg gat att agc agt atc gaa tct cga         96
Ala Thr Thr Val His Ala Gln Thr Asp Ile Ser Ser Ile Glu Ser Arg           
            20                  25                  30                    

ctg gcg gcg ttg gaa caa cgt tta aaa aat gcg gaa tcc cgc gcc cag        144
Leu Ala Ala Leu Glu Gln Arg Leu Lys Asn Ala Glu Ser Arg Ala Gln           
        35                  40                  45                        

gcg gca gaa gca agg gcc aaa aca gct gaa tta cag gtt cag aaa ctg        192
Ala Ala Glu Ala Arg Ala Lys Thr Ala Glu Leu Gln Val Gln Lys Leu           
    50                  55                  60                            

gct gaa aca caa caa caa aat cag cta aca act caa gaa gta gca cag        240
Ala Glu Thr Gln Gln Gln Asn Gln Leu Thr Thr Gln Glu Val Ala Gln           
65                  70                  75                  80            

aga aca gtt cag ctc gaa cag aaa tcc gca gaa aac agt ggt ttt gag        288
Arg Thr Val Gln Leu Glu Gln Lys Ser Ala Glu Asn Ser Gly Phe Glu           
                85                  90                  95                

ttt cat ggc tat gcc cgt tcc ggg tta ctg atg aat gat gcc gct tcc        336
Phe His Gly Tyr Ala Arg Ser Gly Leu Leu Met Asn Asp Ala Ala Ser           
            100                 105                 110                   

agt agc aaa agt ggg ccg tat ctg act ccc gca ggt gaa act ggt gga        384
Ser Ser Lys Ser Gly Pro Tyr Leu Thr Pro Ala Gly Glu Thr Gly Gly           
        115                 120                 125                       

gct gtt ggc cgt ctg gga aat gaa gcc gat acc tat gtc gag tta aat        432
Ala Val Gly Arg Leu Gly Asn Glu Ala Asp Thr Tyr Val Glu Leu Asn           
    130                 135                 140                           

gta gaa cat aaa caa aca cta gat aac ggt gcg acc aca cgc ttt aaa        480
Val Glu His Lys Gln Thr Leu Asp Asn Gly Ala Thr Thr Arg Phe Lys           
145                 150                 155                 160           

gca atg ttg gct gac gga caa aga gat tac aac gac tgg act ggc ggc        528
Ala Met Leu Ala Asp Gly Gln Arg Asp Tyr Asn Asp Trp Thr Gly Gly           
                165                 170                 175               

tcc agt aac ctg aat atc cga cag gct ttt gcc gaa ctg ggc gca tta        576
Ser Ser Asn Leu Asn Ile Arg Gln Ala Phe Ala Glu Leu Gly Ala Leu           
            180                 185                 190                   

cca agt ttt acc gga gca ttc aaa gac agt act gtc tgg gct ggt aaa        624
Pro Ser Phe Thr Gly Ala Phe Lys Asp Ser Thr Val Trp Ala Gly Lys           
        195                 200                 205                       

cgc ttt gat cgc gac aat ttt gat att cac tgg tta gac tcc gat gtc        672
Arg Phe Asp Arg Asp Asn Phe Asp Ile His Trp Leu Asp Ser Asp Val           
    210                 215                 220                           

gta ttt tta gcg gga acg ggc ggc ggt atc tat gac gta aaa tgg aac        720
Val Phe Leu Ala Gly Thr Gly Gly Gly Ile Tyr Asp Val Lys Trp Asn           
225                 230                 235                 240           

gat aca ttc cgc agt aac ttt tct ctc tac gga cgt aat ttc ggc gat        768
Asp Thr Phe Arg Ser Asn Phe Ser Leu Tyr Gly Arg Asn Phe Gly Asp           
                245                 250                 255               

ctt gat gat atc gac aat aac gtt cag aac tac atc ctc acc atg aat        816
Leu Asp Asp Ile Asp Asn Asn Val Gln Asn Tyr Ile Leu Thr Met Asn           
            260                 265                 270                   

cat tat gca ggc ccc ttc cag ttg atg gtt agc gga tta cgg gca aaa        864
His Tyr Ala Gly Pro Phe Gln Leu Met Val Ser Gly Leu Arg Ala Lys           
        275                 280                 285                       

gat aat gat gat cga aaa gat gcc aat ggt gat ctc att caa act gat        912
Asp Asn Asp Asp Arg Lys Asp Ala Asn Gly Asp Leu Ile Gln Thr Asp           
    290                 295                 300                           

gct gca aat act ggc gta cat gcg tta gtt ggt ctg cac aat gac act        960
Ala Ala Asn Thr Gly Val His Ala Leu Val Gly Leu His Asn Asp Thr           
305                 310                 315                 320           

ttc tat ggc ctg cgt gaa ggg acg gca aaa aca gca ctg cta tat ggc       1008
Phe Tyr Gly Leu Arg Glu Gly Thr Ala Lys Thr Ala Leu Leu Tyr Gly           
                325                 330                 335               

cat ggc ctg ggt gcg gaa gtc aaa ggg att ggc tcc gat ggc gct ctg       1056
His Gly Leu Gly Ala Glu Val Lys Gly Ile Gly Ser Asp Gly Ala Leu           
            340                 345                 350                   

ctg tct gag gcg aat acc tgg cgc ttc gca tct tac ggc aca aca cct       1104
Leu Ser Glu Ala Asn Thr Trp Arg Phe Ala Ser Tyr Gly Thr Thr Pro           
        355                 360                 365                       

ctg gga agc ggt tgg tat gtt gcg cca gca att ctc gca caa agc agt       1152
Leu Gly Ser Gly Trp Tyr Val Ala Pro Ala Ile Leu Ala Gln Ser Ser           
    370                 375                 380                           

aaa gat cgt tac gtc aaa ggc gat agc tac gaa tgg gtg acc ttc aat       1200
Lys Asp Arg Tyr Val Lys Gly Asp Ser Tyr Glu Trp Val Thr Phe Asn           
385                 390                 395                 400           

aca cgt ctg atc aaa gag gta aca cag aat ttt gct ctg gcc ttt gag       1248
Thr Arg Leu Ile Lys Glu Val Thr Gln Asn Phe Ala Leu Ala Phe Glu           
                405                 410                 415               

ggt agc tat caa tat atg gat ctg aag cca aag ggg tat caa aac cac       1296
Gly Ser Tyr Gln Tyr Met Asp Leu Lys Pro Lys Gly Tyr Gln Asn His           
            420                 425                 430                   

aac gcc gta aac ggc agc ttc tat aaa ctc acc ttt gct cca act cta       1344
Asn Ala Val Asn Gly Ser Phe Tyr Lys Leu Thr Phe Ala Pro Thr Leu           
        435                 440                 445                       

aaa gct aac gat atc aat aat ttc ttt agc cgt ccg gag ctt cgc ctg       1392
Lys Ala Asn Asp Ile Asn Asn Phe Phe Ser Arg Pro Glu Leu Arg Leu           
    450                 455                 460                           

ttt gcc acc tgg atg gac tgg agc agc aaa ctt gat gat ttt gcc agc       1440
Phe Ala Thr Trp Met Asp Trp Ser Ser Lys Leu Asp Asp Phe Ala Ser           
465                 470                 475                 480           

aat gac gct ttc ggc agc agt ggt ttc aat act ggt gga gag tgg aat       1488
Asn Asp Ala Phe Gly Ser Ser Gly Phe Asn Thr Gly Gly Glu Trp Asn           
                485                 490                 495               

ttt ggt gtc caa atg gaa acc tgg ttt taa                               1518
Phe Gly Val Gln Met Glu Thr Trp Phe                                       
            500                 505                                       


<210>  8
<211>  505
<212>  PRT
<213>  E. coli

<400>  8

Met Tyr Lys Lys Thr Thr Leu Ala Met Leu Ile Ala Leu Leu Thr Gly 
1               5                   10                  15      


Ala Thr Thr Val His Ala Gln Thr Asp Ile Ser Ser Ile Glu Ser Arg 
            20                  25                  30          


Leu Ala Ala Leu Glu Gln Arg Leu Lys Asn Ala Glu Ser Arg Ala Gln 
        35                  40                  45              


Ala Ala Glu Ala Arg Ala Lys Thr Ala Glu Leu Gln Val Gln Lys Leu 
    50                  55                  60                  


Ala Glu Thr Gln Gln Gln Asn Gln Leu Thr Thr Gln Glu Val Ala Gln 
65                  70                  75                  80  


Arg Thr Val Gln Leu Glu Gln Lys Ser Ala Glu Asn Ser Gly Phe Glu 
                85                  90                  95      


Phe His Gly Tyr Ala Arg Ser Gly Leu Leu Met Asn Asp Ala Ala Ser 
            100                 105                 110         


Ser Ser Lys Ser Gly Pro Tyr Leu Thr Pro Ala Gly Glu Thr Gly Gly 
        115                 120                 125             


Ala Val Gly Arg Leu Gly Asn Glu Ala Asp Thr Tyr Val Glu Leu Asn 
    130                 135                 140                 


Val Glu His Lys Gln Thr Leu Asp Asn Gly Ala Thr Thr Arg Phe Lys 
145                 150                 155                 160 


Ala Met Leu Ala Asp Gly Gln Arg Asp Tyr Asn Asp Trp Thr Gly Gly 
                165                 170                 175     


Ser Ser Asn Leu Asn Ile Arg Gln Ala Phe Ala Glu Leu Gly Ala Leu 
            180                 185                 190         


Pro Ser Phe Thr Gly Ala Phe Lys Asp Ser Thr Val Trp Ala Gly Lys 
        195                 200                 205             


Arg Phe Asp Arg Asp Asn Phe Asp Ile His Trp Leu Asp Ser Asp Val 
    210                 215                 220                 


Val Phe Leu Ala Gly Thr Gly Gly Gly Ile Tyr Asp Val Lys Trp Asn 
225                 230                 235                 240 


Asp Thr Phe Arg Ser Asn Phe Ser Leu Tyr Gly Arg Asn Phe Gly Asp 
                245                 250                 255     


Leu Asp Asp Ile Asp Asn Asn Val Gln Asn Tyr Ile Leu Thr Met Asn 
            260                 265                 270         


His Tyr Ala Gly Pro Phe Gln Leu Met Val Ser Gly Leu Arg Ala Lys 
        275                 280                 285             


Asp Asn Asp Asp Arg Lys Asp Ala Asn Gly Asp Leu Ile Gln Thr Asp 
    290                 295                 300                 


Ala Ala Asn Thr Gly Val His Ala Leu Val Gly Leu His Asn Asp Thr 
305                 310                 315                 320 


Phe Tyr Gly Leu Arg Glu Gly Thr Ala Lys Thr Ala Leu Leu Tyr Gly 
                325                 330                 335     


His Gly Leu Gly Ala Glu Val Lys Gly Ile Gly Ser Asp Gly Ala Leu 
            340                 345                 350         


Leu Ser Glu Ala Asn Thr Trp Arg Phe Ala Ser Tyr Gly Thr Thr Pro 
        355                 360                 365             


Leu Gly Ser Gly Trp Tyr Val Ala Pro Ala Ile Leu Ala Gln Ser Ser 
    370                 375                 380                 


Lys Asp Arg Tyr Val Lys Gly Asp Ser Tyr Glu Trp Val Thr Phe Asn 
385                 390                 395                 400 


Thr Arg Leu Ile Lys Glu Val Thr Gln Asn Phe Ala Leu Ala Phe Glu 
                405                 410                 415     


Gly Ser Tyr Gln Tyr Met Asp Leu Lys Pro Lys Gly Tyr Gln Asn His 
            420                 425                 430         


Asn Ala Val Asn Gly Ser Phe Tyr Lys Leu Thr Phe Ala Pro Thr Leu 
        435                 440                 445             


Lys Ala Asn Asp Ile Asn Asn Phe Phe Ser Arg Pro Glu Leu Arg Leu 
    450                 455                 460                 


Phe Ala Thr Trp Met Asp Trp Ser Ser Lys Leu Asp Asp Phe Ala Ser 
465                 470                 475                 480 


Asn Asp Ala Phe Gly Ser Ser Gly Phe Asn Thr Gly Gly Glu Trp Asn 
                485                 490                 495     


Phe Gly Val Gln Met Glu Thr Trp Phe 
            500                 505 


<210>  9
<211>  1341
<212>  DNA
<213>  E. coli


<220>
<221>  CDS
<222>  (1)..(1341)
<223>  gene endocing LamB maltodectrin porin

<400>  9
atg atg att act ctg cgc aaa ctt cct ctg gcg gtt gcc gtc gca gcg         48
Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala           
1               5                   10                  15                

ggc gta atg tct gct cag gca atg gct gtt gat ttc cac ggc tat gca         96
Gly Val Met Ser Ala Gln Ala Met Ala Val Asp Phe His Gly Tyr Ala           
            20                  25                  30                    

cgt tcc ggt att ggt tgg aca ggt agc ggc ggt gaa caa cag tgt ttc        144
Arg Ser Gly Ile Gly Trp Thr Gly Ser Gly Gly Glu Gln Gln Cys Phe           
        35                  40                  45                        

cag act acc ggt gct caa agt aaa tac cgt ctt ggc aac gaa tgt gaa        192
Gln Thr Thr Gly Ala Gln Ser Lys Tyr Arg Leu Gly Asn Glu Cys Glu           
    50                  55                  60                            

act tat gct gaa tta aaa ttg ggt cag gaa gtg tgg aaa gag ggc gat        240
Thr Tyr Ala Glu Leu Lys Leu Gly Gln Glu Val Trp Lys Glu Gly Asp           
65                  70                  75                  80            

aag agc ttc tat ttc gac act aac gtg gcc tat tcc gtc gca caa cag        288
Lys Ser Phe Tyr Phe Asp Thr Asn Val Ala Tyr Ser Val Ala Gln Gln           
                85                  90                  95                

aat gac tgg gaa gct acc gat ccg gcc ttc cgt gaa gca aac gtg cag        336
Asn Asp Trp Glu Ala Thr Asp Pro Ala Phe Arg Glu Ala Asn Val Gln           
            100                 105                 110                   

ggt aaa aac ctg atc gaa tgg ctg cca ggc tcc acc atc tgg gca ggt        384
Gly Lys Asn Leu Ile Glu Trp Leu Pro Gly Ser Thr Ile Trp Ala Gly           
        115                 120                 125                       

aag cgc ttc tac caa cgt cat gac gtt cat atg atc gac ttc tac tac        432
Lys Arg Phe Tyr Gln Arg His Asp Val His Met Ile Asp Phe Tyr Tyr           
    130                 135                 140                           

tgg gat att tct ggt cct ggt gcc ggt ctg gaa aac atc gat gtt ggc        480
Trp Asp Ile Ser Gly Pro Gly Ala Gly Leu Glu Asn Ile Asp Val Gly           
145                 150                 155                 160           

ttc ggt aaa ctc tct ctg gca gca acc cgc tcc tct gaa gct ggt ggt        528
Phe Gly Lys Leu Ser Leu Ala Ala Thr Arg Ser Ser Glu Ala Gly Gly           
                165                 170                 175               

tct tcc tct ttc gcc agc aac aat att tat gac tat acc aac gaa acc        576
Ser Ser Ser Phe Ala Ser Asn Asn Ile Tyr Asp Tyr Thr Asn Glu Thr           
            180                 185                 190                   

gcg aac gac gtt ttc gat gtg cgt tta gcg cag atg gaa atc aac ccg        624
Ala Asn Asp Val Phe Asp Val Arg Leu Ala Gln Met Glu Ile Asn Pro           
        195                 200                 205                       

ggc ggc aca tta gaa ctg ggt gtc gac tac ggt cgt gcc aac ttg cgt        672
Gly Gly Thr Leu Glu Leu Gly Val Asp Tyr Gly Arg Ala Asn Leu Arg           
    210                 215                 220                           

gat aac tat cgt ctg gtt gat ggc gca tcg aaa gac ggc tgg tta ttc        720
Asp Asn Tyr Arg Leu Val Asp Gly Ala Ser Lys Asp Gly Trp Leu Phe           
225                 230                 235                 240           

act gct gaa cat act cag agt gtc ctg aag ggc ttt aac aag ttt gtt        768
Thr Ala Glu His Thr Gln Ser Val Leu Lys Gly Phe Asn Lys Phe Val           
                245                 250                 255               

gtt cag tac gct act gac tcg atg acc tcg cag ggt aaa ggg ctg tcg        816
Val Gln Tyr Ala Thr Asp Ser Met Thr Ser Gln Gly Lys Gly Leu Ser           
            260                 265                 270                   

cag ggt tct ggc gtt gca ttt gat aac gaa aaa ttt gcc tac aat atc        864
Gln Gly Ser Gly Val Ala Phe Asp Asn Glu Lys Phe Ala Tyr Asn Ile           
        275                 280                 285                       

aac aac aac ggt cac atg ctg cgt atc ctc gac cac ggt gcg atc tcc        912
Asn Asn Asn Gly His Met Leu Arg Ile Leu Asp His Gly Ala Ile Ser           
    290                 295                 300                           

atg ggc gac aac tgg gac atg atg tac gtg ggt atg tac cag gat atc        960
Met Gly Asp Asn Trp Asp Met Met Tyr Val Gly Met Tyr Gln Asp Ile           
305                 310                 315                 320           

aac tgg gat aac gac aac ggc acc aag tgg tgg acc gtc ggt att cgc       1008
Asn Trp Asp Asn Asp Asn Gly Thr Lys Trp Trp Thr Val Gly Ile Arg           
                325                 330                 335               

ccg atg tac aag tgg acg cca atc atg agc acc gtg atg gaa atc ggc       1056
Pro Met Tyr Lys Trp Thr Pro Ile Met Ser Thr Val Met Glu Ile Gly           
            340                 345                 350                   

tac gac aac gtc gaa tcc cag cgc acc ggc gac aag aac aat cag tac       1104
Tyr Asp Asn Val Glu Ser Gln Arg Thr Gly Asp Lys Asn Asn Gln Tyr           
        355                 360                 365                       

aaa att acc ctc gca caa caa tgg cag gct ggc gac agc atc tgg tca       1152
Lys Ile Thr Leu Ala Gln Gln Trp Gln Ala Gly Asp Ser Ile Trp Ser           
    370                 375                 380                           

cgc ccg gct att cgt gtc ttc gca acc tac gcc aag tgg gat gag aaa       1200
Arg Pro Ala Ile Arg Val Phe Ala Thr Tyr Ala Lys Trp Asp Glu Lys           
385                 390                 395                 400           

tgg ggt tac gac tac acc ggt aac gct gat aac aac gcg aac ttc ggc       1248
Trp Gly Tyr Asp Tyr Thr Gly Asn Ala Asp Asn Asn Ala Asn Phe Gly           
                405                 410                 415               

aaa gcc gtt cct gct gat ttc aac ggc ggc agc ttc ggt cgt ggc gac       1296
Lys Ala Val Pro Ala Asp Phe Asn Gly Gly Ser Phe Gly Arg Gly Asp           
            420                 425                 430                   

agc gac gag tgg acc ttc ggt gcc cag atg gaa atc tgg tgg taa           1341
Ser Asp Glu Trp Thr Phe Gly Ala Gln Met Glu Ile Trp Trp                   
        435                 440                 445                       


<210>  10
<211>  446
<212>  PRT
<213>  E. coli

<400>  10

Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala 
1               5                   10                  15      


Gly Val Met Ser Ala Gln Ala Met Ala Val Asp Phe His Gly Tyr Ala 
            20                  25                  30          


Arg Ser Gly Ile Gly Trp Thr Gly Ser Gly Gly Glu Gln Gln Cys Phe 
        35                  40                  45              


Gln Thr Thr Gly Ala Gln Ser Lys Tyr Arg Leu Gly Asn Glu Cys Glu 
    50                  55                  60                  


Thr Tyr Ala Glu Leu Lys Leu Gly Gln Glu Val Trp Lys Glu Gly Asp 
65                  70                  75                  80  


Lys Ser Phe Tyr Phe Asp Thr Asn Val Ala Tyr Ser Val Ala Gln Gln 
                85                  90                  95      


Asn Asp Trp Glu Ala Thr Asp Pro Ala Phe Arg Glu Ala Asn Val Gln 
            100                 105                 110         


Gly Lys Asn Leu Ile Glu Trp Leu Pro Gly Ser Thr Ile Trp Ala Gly 
        115                 120                 125             


Lys Arg Phe Tyr Gln Arg His Asp Val His Met Ile Asp Phe Tyr Tyr 
    130                 135                 140                 


Trp Asp Ile Ser Gly Pro Gly Ala Gly Leu Glu Asn Ile Asp Val Gly 
145                 150                 155                 160 


Phe Gly Lys Leu Ser Leu Ala Ala Thr Arg Ser Ser Glu Ala Gly Gly 
                165                 170                 175     


Ser Ser Ser Phe Ala Ser Asn Asn Ile Tyr Asp Tyr Thr Asn Glu Thr 
            180                 185                 190         


Ala Asn Asp Val Phe Asp Val Arg Leu Ala Gln Met Glu Ile Asn Pro 
        195                 200                 205             


Gly Gly Thr Leu Glu Leu Gly Val Asp Tyr Gly Arg Ala Asn Leu Arg 
    210                 215                 220                 


Asp Asn Tyr Arg Leu Val Asp Gly Ala Ser Lys Asp Gly Trp Leu Phe 
225                 230                 235                 240 


Thr Ala Glu His Thr Gln Ser Val Leu Lys Gly Phe Asn Lys Phe Val 
                245                 250                 255     


Val Gln Tyr Ala Thr Asp Ser Met Thr Ser Gln Gly Lys Gly Leu Ser 
            260                 265                 270         


Gln Gly Ser Gly Val Ala Phe Asp Asn Glu Lys Phe Ala Tyr Asn Ile 
        275                 280                 285             


Asn Asn Asn Gly His Met Leu Arg Ile Leu Asp His Gly Ala Ile Ser 
    290                 295                 300                 


Met Gly Asp Asn Trp Asp Met Met Tyr Val Gly Met Tyr Gln Asp Ile 
305                 310                 315                 320 


Asn Trp Asp Asn Asp Asn Gly Thr Lys Trp Trp Thr Val Gly Ile Arg 
                325                 330                 335     


Pro Met Tyr Lys Trp Thr Pro Ile Met Ser Thr Val Met Glu Ile Gly 
            340                 345                 350         


Tyr Asp Asn Val Glu Ser Gln Arg Thr Gly Asp Lys Asn Asn Gln Tyr 
        355                 360                 365             


Lys Ile Thr Leu Ala Gln Gln Trp Gln Ala Gly Asp Ser Ile Trp Ser 
    370                 375                 380                 


Arg Pro Ala Ile Arg Val Phe Ala Thr Tyr Ala Lys Trp Asp Glu Lys 
385                 390                 395                 400 


Trp Gly Tyr Asp Tyr Thr Gly Asn Ala Asp Asn Asn Ala Asn Phe Gly 
                405                 410                 415     


Lys Ala Val Pro Ala Asp Phe Asn Gly Gly Ser Phe Gly Arg Gly Asp 
            420                 425                 430         


Ser Asp Glu Trp Thr Phe Gly Ala Gln Met Glu Ile Trp Trp 
        435                 440                 445     


<210>  11
<211>  1344
<212>  DNA
<213>  Pseudomonas putida


<220>
<221>  CDS
<222>  (1)..(1344)
<223>  carbohydrate porin from Pseudomonas putida

<400>  11
atg gaa cag cgc aaa cgc atc aag aca ctg gga tcg ttg gcc ttg ctt         48
Met Glu Gln Arg Lys Arg Ile Lys Thr Leu Gly Ser Leu Ala Leu Leu           
1               5                   10                  15                

gca ctt gta ggc agc agc ggt aca cag gct gcc gag gct ttt tcc agc         96
Ala Leu Val Gly Ser Ser Gly Thr Gln Ala Ala Glu Ala Phe Ser Ser           
            20                  25                  30                    

gaa tcc aaa tgg atg acc ggc gac tgg ggc ggc acc cgg acc gag ctg        144
Glu Ser Lys Trp Met Thr Gly Asp Trp Gly Gly Thr Arg Thr Glu Leu           
        35                  40                  45                        

ctg gac aag ggc tat gac ttc acc ctc gat tat gtg ggt gag gtg gct        192
Leu Asp Lys Gly Tyr Asp Phe Thr Leu Asp Tyr Val Gly Glu Val Ala           
    50                  55                  60                            

ggc aac ctg cat ggc ggc tac aac gac gac aag acg gca cgc tac agc        240
Gly Asn Leu His Gly Gly Tyr Asn Asp Asp Lys Thr Ala Arg Tyr Ser           
65                  70                  75                  80            

gac cag ttc gcc ctc ggc gcg cat ctg gac ttg cag aag ata ctg ggc        288
Asp Gln Phe Ala Leu Gly Ala His Leu Asp Leu Gln Lys Ile Leu Gly           
                85                  90                  95                

tgg cat gat gcc gag ttc aag ctg gca atc acc gag cga agc ggt cgc        336
Trp His Asp Ala Glu Phe Lys Leu Ala Ile Thr Glu Arg Ser Gly Arg           
            100                 105                 110                   

aac ctg tcc aac gac cgc atc agc gac ccg cgc gcc ggg cag ttc agc        384
Asn Leu Ser Asn Asp Arg Ile Ser Asp Pro Arg Ala Gly Gln Phe Ser           
        115                 120                 125                       

tcg gtg cag gag gtg tgg ggc cgt ggc cag acc tgg cgc ctg acc cag        432
Ser Val Gln Glu Val Trp Gly Arg Gly Gln Thr Trp Arg Leu Thr Gln           
    130                 135                 140                           

atg tgg atc aag cag aag tac ttc gac ggc gcg ctg gac gtg aaa ttt        480
Met Trp Ile Lys Gln Lys Tyr Phe Asp Gly Ala Leu Asp Val Lys Phe           
145                 150                 155                 160           

ggc cgt ttt ggc gag ggc gag gac ttc aac agc ttc cct tgc gac ttc        528
Gly Arg Phe Gly Glu Gly Glu Asp Phe Asn Ser Phe Pro Cys Asp Phe           
                165                 170                 175               

cag aac ctg gcc ttc tgc ggc tcg cag gtg ggc aac tgg gtg ggc ggc        576
Gln Asn Leu Ala Phe Cys Gly Ser Gln Val Gly Asn Trp Val Gly Gly           
            180                 185                 190                   

atc tgg tac aac tgg ccg gtc agc cag tgg gcg ctg cgg gtg aag tac        624
Ile Trp Tyr Asn Trp Pro Val Ser Gln Trp Ala Leu Arg Val Lys Tyr           
        195                 200                 205                       

aac atc acg ccg gag ttc ttc gta cag gtc ggg gcc ttc gag cag aac        672
Asn Ile Thr Pro Glu Phe Phe Val Gln Val Gly Ala Phe Glu Gln Asn           
    210                 215                 220                           

cct tcc aac ctg gaa acc ggc aac ggc ttc aag ctc agc ggc agt ggt        720
Pro Ser Asn Leu Glu Thr Gly Asn Gly Phe Lys Leu Ser Gly Ser Gly           
225                 230                 235                 240           

acc aag ggg gcg atc ttg ccg gtg gaa gcg gtg tgg tcg ccc aag gtc        768
Thr Lys Gly Ala Ile Leu Pro Val Glu Ala Val Trp Ser Pro Lys Val           
                245                 250                 255               

aat ggc ctg ccg ggc gag tac cgc ctg ggt tac tac tac agc acg gcc        816
Asn Gly Leu Pro Gly Glu Tyr Arg Leu Gly Tyr Tyr Tyr Ser Thr Ala           
            260                 265                 270                   

aag gct gac gat gtg tac gac gac gtc aac ggc aac ccg cag gcg ctg        864
Lys Ala Asp Asp Val Tyr Asp Asp Val Asn Gly Asn Pro Gln Ala Leu           
        275                 280                 285                       

aca ggt gaa gcc ttc aag tcg cac tcc agc aag cac gga tgg tgg gtg        912
Thr Gly Glu Ala Phe Lys Ser His Ser Ser Lys His Gly Trp Trp Val           
    290                 295                 300                           

gtg gcg cag cag cag gtc act gcc cat ggc ggc gac gtc aac cgg ggc        960
Val Ala Gln Gln Gln Val Thr Ala His Gly Gly Asp Val Asn Arg Gly           
305                 310                 315                 320           

ctc agc ctg ttc gcc aac ttc acc gtg cac gac aag gcc acc aac gtg       1008
Leu Ser Leu Phe Ala Asn Phe Thr Val His Asp Lys Ala Thr Asn Val           
                325                 330                 335               

gtc gac aac tac cag cag gtg ggg ctg gtc tac aaa ggc gct ttc gac       1056
Val Asp Asn Tyr Gln Gln Val Gly Leu Val Tyr Lys Gly Ala Phe Asp           
            340                 345                 350                   

gcc cgg ccc aag gat gac atc ggc ttc ggc gtg gcg cgt att cat gtg       1104
Ala Arg Pro Lys Asp Asp Ile Gly Phe Gly Val Ala Arg Ile His Val           
        355                 360                 365                       

aat gac gac gtg aag aag cgc gcc gaa ctg ctc aac gca cag agc ggc       1152
Asn Asp Asp Val Lys Lys Arg Ala Glu Leu Leu Asn Ala Gln Ser Gly           
    370                 375                 380                           

atc aac gat tac gac aac cct ggt ttc gtg ccg ctg cag cgt acc gaa       1200
Ile Asn Asp Tyr Asp Asn Pro Gly Phe Val Pro Leu Gln Arg Thr Glu           
385                 390                 395                 400           

tac aac gca gag ctc tac tac ggc ttc cac gtt acc aac tgg ctg acc       1248
Tyr Asn Ala Glu Leu Tyr Tyr Gly Phe His Val Thr Asn Trp Leu Thr           
                405                 410                 415               

gtg agg ccc aac ctg cag tac atc aag agc cct ggc ggg gtg gac gag       1296
Val Arg Pro Asn Leu Gln Tyr Ile Lys Ser Pro Gly Gly Val Asp Glu           
            420                 425                 430                   

gtg gat aac gcg ctg gtc gct ggc ttg aag att cag tcg tca ttc tga       1344
Val Asp Asn Ala Leu Val Ala Gly Leu Lys Ile Gln Ser Ser Phe               
        435                 440                 445                       


<210>  12
<211>  447
<212>  PRT
<213>  Pseudomonas putida

<400>  12

Met Glu Gln Arg Lys Arg Ile Lys Thr Leu Gly Ser Leu Ala Leu Leu 
1               5                   10                  15      


Ala Leu Val Gly Ser Ser Gly Thr Gln Ala Ala Glu Ala Phe Ser Ser 
            20                  25                  30          


Glu Ser Lys Trp Met Thr Gly Asp Trp Gly Gly Thr Arg Thr Glu Leu 
        35                  40                  45              


Leu Asp Lys Gly Tyr Asp Phe Thr Leu Asp Tyr Val Gly Glu Val Ala 
    50                  55                  60                  


Gly Asn Leu His Gly Gly Tyr Asn Asp Asp Lys Thr Ala Arg Tyr Ser 
65                  70                  75                  80  


Asp Gln Phe Ala Leu Gly Ala His Leu Asp Leu Gln Lys Ile Leu Gly 
                85                  90                  95      


Trp His Asp Ala Glu Phe Lys Leu Ala Ile Thr Glu Arg Ser Gly Arg 
            100                 105                 110         


Asn Leu Ser Asn Asp Arg Ile Ser Asp Pro Arg Ala Gly Gln Phe Ser 
        115                 120                 125             


Ser Val Gln Glu Val Trp Gly Arg Gly Gln Thr Trp Arg Leu Thr Gln 
    130                 135                 140                 


Met Trp Ile Lys Gln Lys Tyr Phe Asp Gly Ala Leu Asp Val Lys Phe 
145                 150                 155                 160 


Gly Arg Phe Gly Glu Gly Glu Asp Phe Asn Ser Phe Pro Cys Asp Phe 
                165                 170                 175     


Gln Asn Leu Ala Phe Cys Gly Ser Gln Val Gly Asn Trp Val Gly Gly 
            180                 185                 190         


Ile Trp Tyr Asn Trp Pro Val Ser Gln Trp Ala Leu Arg Val Lys Tyr 
        195                 200                 205             


Asn Ile Thr Pro Glu Phe Phe Val Gln Val Gly Ala Phe Glu Gln Asn 
    210                 215                 220                 


Pro Ser Asn Leu Glu Thr Gly Asn Gly Phe Lys Leu Ser Gly Ser Gly 
225                 230                 235                 240 


Thr Lys Gly Ala Ile Leu Pro Val Glu Ala Val Trp Ser Pro Lys Val 
                245                 250                 255     


Asn Gly Leu Pro Gly Glu Tyr Arg Leu Gly Tyr Tyr Tyr Ser Thr Ala 
            260                 265                 270         


Lys Ala Asp Asp Val Tyr Asp Asp Val Asn Gly Asn Pro Gln Ala Leu 
        275                 280                 285             


Thr Gly Glu Ala Phe Lys Ser His Ser Ser Lys His Gly Trp Trp Val 
    290                 295                 300                 


Val Ala Gln Gln Gln Val Thr Ala His Gly Gly Asp Val Asn Arg Gly 
305                 310                 315                 320 


Leu Ser Leu Phe Ala Asn Phe Thr Val His Asp Lys Ala Thr Asn Val 
                325                 330                 335     


Val Asp Asn Tyr Gln Gln Val Gly Leu Val Tyr Lys Gly Ala Phe Asp 
            340                 345                 350         


Ala Arg Pro Lys Asp Asp Ile Gly Phe Gly Val Ala Arg Ile His Val 
        355                 360                 365             


Asn Asp Asp Val Lys Lys Arg Ala Glu Leu Leu Asn Ala Gln Ser Gly 
    370                 375                 380                 


Ile Asn Asp Tyr Asp Asn Pro Gly Phe Val Pro Leu Gln Arg Thr Glu 
385                 390                 395                 400 


Tyr Asn Ala Glu Leu Tyr Tyr Gly Phe His Val Thr Asn Trp Leu Thr 
                405                 410                 415     


Val Arg Pro Asn Leu Gln Tyr Ile Lys Ser Pro Gly Gly Val Asp Glu 
            420                 425                 430         


Val Asp Asn Ala Leu Val Ala Gly Leu Lys Ile Gln Ser Ser Phe 
        435                 440                 445         


<210>  13
<211>  1671
<212>  DNA
<213>  Bifidobacterium


<220>
<221>  CDS
<222>  (1)..(1671)
<223>  gene ecoding alpha-glucosidase melD

<400>  13
atg act ttc acc aac aat gac tgg tgg cgc gac gcc gtc atc tac cag         48
Met Thr Phe Thr Asn Asn Asp Trp Trp Arg Asp Ala Val Ile Tyr Gln           
1               5                   10                  15                

att tac ccc cgc tca ttc agc gat gcc aat gga gac ggc aac ggt gat         96
Ile Tyr Pro Arg Ser Phe Ser Asp Ala Asn Gly Asp Gly Asn Gly Asp           
            20                  25                  30                    

ctc caa ggc gtg atc gat cgt ctc gac tat ctg cag gcg ctc ggg gtg        144
Leu Gln Gly Val Ile Asp Arg Leu Asp Tyr Leu Gln Ala Leu Gly Val           
        35                  40                  45                        

gac gcg ctc tgg ctt tct cca ttc tat cca tcg ccg ctg gcg gat gga        192
Asp Ala Leu Trp Leu Ser Pro Phe Tyr Pro Ser Pro Leu Ala Asp Gly           
    50                  55                  60                            

ggt tat gat gtt gcc gac tat tgc gat gtg gat ccc cgc ctt ggc aca        240
Gly Tyr Asp Val Ala Asp Tyr Cys Asp Val Asp Pro Arg Leu Gly Thr           
65                  70                  75                  80            

ctc gat cag ttc gac gaa tta gtg gcc aaa gcg cac gaa cgc ggt atc        288
Leu Asp Gln Phe Asp Glu Leu Val Ala Lys Ala His Glu Arg Gly Ile           
                85                  90                  95                

ggc atc atc gtg gac atc gtg ccg aac cac acg tcc gat cag cac cgt        336
Gly Ile Ile Val Asp Ile Val Pro Asn His Thr Ser Asp Gln His Arg           
            100                 105                 110                   

tgg ttc caa gag gcc ctg gct caa ggt ccg gaa tcg gaa acg gca caa        384
Trp Phe Gln Glu Ala Leu Ala Gln Gly Pro Glu Ser Glu Thr Ala Gln           
        115                 120                 125                       

cgg tat gtg ttc cgg cag ggc aag ggg gag cac ggc gaa ttg ccg cct        432
Arg Tyr Val Phe Arg Gln Gly Lys Gly Glu His Gly Glu Leu Pro Pro           
    130                 135                 140                           

acc aac tgg ctg agt aac ttc ggc ggt tcc gca tgg gag tcg tgt gga        480
Thr Asn Trp Leu Ser Asn Phe Gly Gly Ser Ala Trp Glu Ser Cys Gly           
145                 150                 155                 160           

gac ggc tgg tac tac ctg cat ctg ttc gcc aag gag cag ccg gac ctc        528
Asp Gly Trp Tyr Tyr Leu His Leu Phe Ala Lys Glu Gln Pro Asp Leu           
                165                 170                 175               

aat tgg gac aat ccc gag gtg cgg cat gag ttc ctg cgt gta ctc aca        576
Asn Trp Asp Asn Pro Glu Val Arg His Glu Phe Leu Arg Val Leu Thr           
            180                 185                 190                   

ttc tgg tgc gat cgc ggc gtg gac ggt ttc cgc atc gat gtc tcg cac        624
Phe Trp Cys Asp Arg Gly Val Asp Gly Phe Arg Ile Asp Val Ser His           
        195                 200                 205                       

ggt ctg gcc aaa gac ctg cgt gag ccg ctg cgc gac cgt atc gac ccg        672
Gly Leu Ala Lys Asp Leu Arg Glu Pro Leu Arg Asp Arg Ile Asp Pro           
    210                 215                 220                           

aca ctg atg tct cca cag gct acc gat ggt tcc gat ccg ctc tgg gac        720
Thr Leu Met Ser Pro Gln Ala Thr Asp Gly Ser Asp Pro Leu Trp Asp           
225                 230                 235                 240           

cgc gac gcc gtg cat gat atc tac cgt gaa tgg cgc gac ctg ttc aat        768
Arg Asp Ala Val His Asp Ile Tyr Arg Glu Trp Arg Asp Leu Phe Asn           
                245                 250                 255               

cag tac atg cca gcc aag tat gcg gtc ggc gaa tcg tgg tcg cca ttc        816
Gln Tyr Met Pro Ala Lys Tyr Ala Val Gly Glu Ser Trp Ser Pro Phe           
            260                 265                 270                   

acc acc cgt att ttc caa tac gcc aag cct gat gaa ctt ggt gcc gta        864
Thr Thr Arg Ile Phe Gln Tyr Ala Lys Pro Asp Glu Leu Gly Ala Val           
        275                 280                 285                       

ttt gac ttc tcc atg tca aag gcc gcc tgg aat cgc gaa gaa tac cgc        912
Phe Asp Phe Ser Met Ser Lys Ala Ala Trp Asn Arg Glu Glu Tyr Arg           
    290                 295                 300                           

acc acg att gag cgc acg cat cgc tat gct ctc gct gcc gaa acc gcc        960
Thr Thr Ile Glu Arg Thr His Arg Tyr Ala Leu Ala Ala Glu Thr Ala           
305                 310                 315                 320           

ccc acc tgg gtg ctc ggc aac cac gat gtg cca cgt atc gcc tcg cgt       1008
Pro Thr Trp Val Leu Gly Asn His Asp Val Pro Arg Ile Ala Ser Arg           
                325                 330                 335               

ctc gga ctg ccg agc ggt gca aac atc gag cag tgg gtg acg tcc aac       1056
Leu Gly Leu Pro Ser Gly Ala Asn Ile Glu Gln Trp Val Thr Ser Asn           
            340                 345                 350                   

ggc acg aat ccg ccg att gac ccc gcg ctc gcc gct cgt cgt gcc cgt       1104
Gly Thr Asn Pro Pro Ile Asp Pro Ala Leu Ala Ala Arg Arg Ala Arg           
        355                 360                 365                       

gca gca gcg ctg gtg atg ctc ggc ctg cca ggt acc gcc ttt gtg tat       1152
Ala Ala Ala Leu Val Met Leu Gly Leu Pro Gly Thr Ala Phe Val Tyr           
    370                 375                 380                           

cag ggt gaa gag ctt ggt ttg cct gag gac ttt gat ttg acc gaa gat       1200
Gln Gly Glu Glu Leu Gly Leu Pro Glu Asp Phe Asp Leu Thr Glu Asp           
385                 390                 395                 400           

gaa att cag gat ccc aat tgg gaa cgt tcc ggt cat tat ttc aag ggg       1248
Glu Ile Gln Asp Pro Asn Trp Glu Arg Ser Gly His Tyr Phe Lys Gly           
                405                 410                 415               

cgc gac ggt tgc cgc gta ccg ctg ccg tgg cag tca gac ggc ccg gcg       1296
Arg Asp Gly Cys Arg Val Pro Leu Pro Trp Gln Ser Asp Gly Pro Ala           
            420                 425                 430                   

ttc ggc ttc aat gcc acc ggt gct ttg tgg ctg ccc cag ccg gca tgg       1344
Phe Gly Phe Asn Ala Thr Gly Ala Leu Trp Leu Pro Gln Pro Ala Trp           
        435                 440                 445                       

ttt gcg cag tat gcc gct aat cgt cag att ggt gac ggg gct tcc gtc       1392
Phe Ala Gln Tyr Ala Ala Asn Arg Gln Ile Gly Asp Gly Ala Ser Val           
    450                 455                 460                           

ctg cac ctg tat cgt gct gcc atc gca ttg cgc aaa cag tgg gtg gac       1440
Leu His Leu Tyr Arg Ala Ala Ile Ala Leu Arg Lys Gln Trp Val Asp           
465                 470                 475                 480           

aac ggc acg gac ttc cag ttc tcg tgg ctt acc aac gaa gag tgt ccg       1488
Asn Gly Thr Asp Phe Gln Phe Ser Trp Leu Thr Asn Glu Glu Cys Pro           
                485                 490                 495               

gcg ccg ctg ctt ggt tgg cgc ttg ccg tcc ggc atg gtt gtg atg gcg       1536
Ala Pro Leu Leu Gly Trp Arg Leu Pro Ser Gly Met Val Val Met Ala           
            500                 505                 510                   

aac ttc tct gac agt caa cca gtc gcc ttg ccg cag ccg atg acc gtg       1584
Asn Phe Ser Asp Ser Gln Pro Val Ala Leu Pro Gln Pro Met Thr Val           
        515                 520                 525                       

cta ctt gtg tct gat gcg act gtg cag gcg aac act cag gtc gag agc       1632
Leu Leu Val Ser Asp Ala Thr Val Gln Ala Asn Thr Gln Val Glu Ser           
    530                 535                 540                           

gtt cct cca gct gct acc gtc tgg gcc ttg cca gca taa                   1671
Val Pro Pro Ala Ala Thr Val Trp Ala Leu Pro Ala                           
545                 550                 555                               


<210>  14
<211>  556
<212>  PRT
<213>  Bifidobacterium

<400>  14

Met Thr Phe Thr Asn Asn Asp Trp Trp Arg Asp Ala Val Ile Tyr Gln 
1               5                   10                  15      


Ile Tyr Pro Arg Ser Phe Ser Asp Ala Asn Gly Asp Gly Asn Gly Asp 
            20                  25                  30          


Leu Gln Gly Val Ile Asp Arg Leu Asp Tyr Leu Gln Ala Leu Gly Val 
        35                  40                  45              


Asp Ala Leu Trp Leu Ser Pro Phe Tyr Pro Ser Pro Leu Ala Asp Gly 
    50                  55                  60                  


Gly Tyr Asp Val Ala Asp Tyr Cys Asp Val Asp Pro Arg Leu Gly Thr 
65                  70                  75                  80  


Leu Asp Gln Phe Asp Glu Leu Val Ala Lys Ala His Glu Arg Gly Ile 
                85                  90                  95      


Gly Ile Ile Val Asp Ile Val Pro Asn His Thr Ser Asp Gln His Arg 
            100                 105                 110         


Trp Phe Gln Glu Ala Leu Ala Gln Gly Pro Glu Ser Glu Thr Ala Gln 
        115                 120                 125             


Arg Tyr Val Phe Arg Gln Gly Lys Gly Glu His Gly Glu Leu Pro Pro 
    130                 135                 140                 


Thr Asn Trp Leu Ser Asn Phe Gly Gly Ser Ala Trp Glu Ser Cys Gly 
145                 150                 155                 160 


Asp Gly Trp Tyr Tyr Leu His Leu Phe Ala Lys Glu Gln Pro Asp Leu 
                165                 170                 175     


Asn Trp Asp Asn Pro Glu Val Arg His Glu Phe Leu Arg Val Leu Thr 
            180                 185                 190         


Phe Trp Cys Asp Arg Gly Val Asp Gly Phe Arg Ile Asp Val Ser His 
        195                 200                 205             


Gly Leu Ala Lys Asp Leu Arg Glu Pro Leu Arg Asp Arg Ile Asp Pro 
    210                 215                 220                 


Thr Leu Met Ser Pro Gln Ala Thr Asp Gly Ser Asp Pro Leu Trp Asp 
225                 230                 235                 240 


Arg Asp Ala Val His Asp Ile Tyr Arg Glu Trp Arg Asp Leu Phe Asn 
                245                 250                 255     


Gln Tyr Met Pro Ala Lys Tyr Ala Val Gly Glu Ser Trp Ser Pro Phe 
            260                 265                 270         


Thr Thr Arg Ile Phe Gln Tyr Ala Lys Pro Asp Glu Leu Gly Ala Val 
        275                 280                 285             


Phe Asp Phe Ser Met Ser Lys Ala Ala Trp Asn Arg Glu Glu Tyr Arg 
    290                 295                 300                 


Thr Thr Ile Glu Arg Thr His Arg Tyr Ala Leu Ala Ala Glu Thr Ala 
305                 310                 315                 320 


Pro Thr Trp Val Leu Gly Asn His Asp Val Pro Arg Ile Ala Ser Arg 
                325                 330                 335     


Leu Gly Leu Pro Ser Gly Ala Asn Ile Glu Gln Trp Val Thr Ser Asn 
            340                 345                 350         


Gly Thr Asn Pro Pro Ile Asp Pro Ala Leu Ala Ala Arg Arg Ala Arg 
        355                 360                 365             


Ala Ala Ala Leu Val Met Leu Gly Leu Pro Gly Thr Ala Phe Val Tyr 
    370                 375                 380                 


Gln Gly Glu Glu Leu Gly Leu Pro Glu Asp Phe Asp Leu Thr Glu Asp 
385                 390                 395                 400 


Glu Ile Gln Asp Pro Asn Trp Glu Arg Ser Gly His Tyr Phe Lys Gly 
                405                 410                 415     


Arg Asp Gly Cys Arg Val Pro Leu Pro Trp Gln Ser Asp Gly Pro Ala 
            420                 425                 430         


Phe Gly Phe Asn Ala Thr Gly Ala Leu Trp Leu Pro Gln Pro Ala Trp 
        435                 440                 445             


Phe Ala Gln Tyr Ala Ala Asn Arg Gln Ile Gly Asp Gly Ala Ser Val 
    450                 455                 460                 


Leu His Leu Tyr Arg Ala Ala Ile Ala Leu Arg Lys Gln Trp Val Asp 
465                 470                 475                 480 


Asn Gly Thr Asp Phe Gln Phe Ser Trp Leu Thr Asn Glu Glu Cys Pro 
                485                 490                 495     


Ala Pro Leu Leu Gly Trp Arg Leu Pro Ser Gly Met Val Val Met Ala 
            500                 505                 510         


Asn Phe Ser Asp Ser Gln Pro Val Ala Leu Pro Gln Pro Met Thr Val 
        515                 520                 525             


Leu Leu Val Ser Asp Ala Thr Val Gln Ala Asn Thr Gln Val Glu Ser 
    530                 535                 540                 


Val Pro Pro Ala Ala Thr Val Trp Ala Leu Pro Ala 
545                 550                 555     


<210>  15
<211>  1437
<212>  DNA
<213>  Bifidobacterium


<220>
<221>  CDS
<222>  (1)..(1437)
<223>  gene enocding 1,3-fucosidase (blon_2336)

<400>  15
atg aac aat cct gca gat gcg ggc atc aac ctg aac tat ctc gcg aat         48
Met Asn Asn Pro Ala Asp Ala Gly Ile Asn Leu Asn Tyr Leu Ala Asn           
1               5                   10                  15                

gtg cgc cca tcg tcg cgc cag ctt gcc tgg cag cgc atg gag atg tac         96
Val Arg Pro Ser Ser Arg Gln Leu Ala Trp Gln Arg Met Glu Met Tyr           
            20                  25                  30                    

gcc ttc ctg cac ttc ggc atg aac acc atg acg gac agg gag tgg ggt        144
Ala Phe Leu His Phe Gly Met Asn Thr Met Thr Asp Arg Glu Trp Gly           
        35                  40                  45                        

ctt ggg cat gag gat ccg gca ctg ttc aac ccg cgg aac gtg gac gtg        192
Leu Gly His Glu Asp Pro Ala Leu Phe Asn Pro Arg Asn Val Asp Val           
    50                  55                  60                            

gac cag tgg atg gac gcg ctg gtg gcc ggc ggg atg gcc ggc gtc atc        240
Asp Gln Trp Met Asp Ala Leu Val Ala Gly Gly Met Ala Gly Val Ile           
65                  70                  75                  80            

ctg acg tgc aag cac cac gac gga ttc tgc ctg tgg ccg tcc cga ttg        288
Leu Thr Cys Lys His His Asp Gly Phe Cys Leu Trp Pro Ser Arg Leu           
                85                  90                  95                

acg cgg cac acc gtc gcc tcg tcg ccg tgg cgt gaa ggc aag ggc gac        336
Thr Arg His Thr Val Ala Ser Ser Pro Trp Arg Glu Gly Lys Gly Asp           
            100                 105                 110                   

ctc gtt cgt gag gtc agc gag tcc gcc agg cgt cac gga ctg aag ttc        384
Leu Val Arg Glu Val Ser Glu Ser Ala Arg Arg His Gly Leu Lys Phe           
        115                 120                 125                       

ggc gtg tac ctg tcc ccg tgg gac cgc acc gag gaa tcc tac ggc aag        432
Gly Val Tyr Leu Ser Pro Trp Asp Arg Thr Glu Glu Ser Tyr Gly Lys           
    130                 135                 140                           

ggc aag gcg tac gac gac ttc tac gtc ggc cag ctg acc gag ctg ctc        480
Gly Lys Ala Tyr Asp Asp Phe Tyr Val Gly Gln Leu Thr Glu Leu Leu           
145                 150                 155                 160           

acc cag tac ggg ccg atc ttc tcc gtc tgg ctt gat ggc gcc aat ggc        528
Thr Gln Tyr Gly Pro Ile Phe Ser Val Trp Leu Asp Gly Ala Asn Gly           
                165                 170                 175               

gag ggc aag aac ggc aag acc cag tac tac gac tgg gat cgt tac tac        576
Glu Gly Lys Asn Gly Lys Thr Gln Tyr Tyr Asp Trp Asp Arg Tyr Tyr           
            180                 185                 190                   

aac gtc atc cgt tcg ctc cag ccc gat gcg gtg att tcc gtg tgc ggc        624
Asn Val Ile Arg Ser Leu Gln Pro Asp Ala Val Ile Ser Val Cys Gly           
        195                 200                 205                       

ccc gac gtg cgc tgg gcc ggg aac gaa gcc ggg cat gtg cgc gac aac        672
Pro Asp Val Arg Trp Ala Gly Asn Glu Ala Gly His Val Arg Asp Asn           
    210                 215                 220                           

gaa tgg agc gtc gtg ccc cgc cgc ctg cgt tcg gcg gaa ctg acc atg        720
Glu Trp Ser Val Val Pro Arg Arg Leu Arg Ser Ala Glu Leu Thr Met           
225                 230                 235                 240           

gag aag tcg cag cag gag gat gac gca tcc ttc gcc acc acg gtc agc        768
Glu Lys Ser Gln Gln Glu Asp Asp Ala Ser Phe Ala Thr Thr Val Ser           
                245                 250                 255               

tcc cag gac gac gac ctc ggc agc cgt gag gcg gtc gcc gga tac ggg        816
Ser Gln Asp Asp Asp Leu Gly Ser Arg Glu Ala Val Ala Gly Tyr Gly           
            260                 265                 270                   

gac aac gtc tgc tgg tac ccg gcc gag gtc gac acc tcc atc cgc ccc        864
Asp Asn Val Cys Trp Tyr Pro Ala Glu Val Asp Thr Ser Ile Arg Pro           
        275                 280                 285                       

ggg tgg ttc tac cac cag tcc gag gac gac aag gtc atg agc gcc gat        912
Gly Trp Phe Tyr His Gln Ser Glu Asp Asp Lys Val Met Ser Ala Asp           
    290                 295                 300                           

cag ctg ttc gac ctc tgg ctt tcc gcg gta ggc ggc aat tca tcg ttg        960
Gln Leu Phe Asp Leu Trp Leu Ser Ala Val Gly Gly Asn Ser Ser Leu           
305                 310                 315                 320           

ctg ctc aac att cct ccc tcg ccg gaa ggt ctg ctc gcc gaa ccg gat       1008
Leu Leu Asn Ile Pro Pro Ser Pro Glu Gly Leu Leu Ala Glu Pro Asp           
                325                 330                 335               

gtg cag tcg ctc aag gga ttg ggc cgc cgc gtc agc gag ttc cgt gaa       1056
Val Gln Ser Leu Lys Gly Leu Gly Arg Arg Val Ser Glu Phe Arg Glu           
            340                 345                 350                   

gcg ctg gcc tcg gtc cgc tgc gaa gcc agg acc agc agc gca tcc gcc       1104
Ala Leu Ala Ser Val Arg Cys Glu Ala Arg Thr Ser Ser Ala Ser Ala           
        355                 360                 365                       

gcc gcg gcg cat ctc gtc gac ggg aat cgg gac acg ttc tgg cgc ccg       1152
Ala Ala Ala His Leu Val Asp Gly Asn Arg Asp Thr Phe Trp Arg Pro           
    370                 375                 380                           

gat gcc gac gat gcg gcc ccc gcc atc acg ctc acc ctc ccg cag ccc       1200
Asp Ala Asp Asp Ala Ala Pro Ala Ile Thr Leu Thr Leu Pro Gln Pro           
385                 390                 395                 400           

acg acg atc aac gcc atc gtg atc gag gag gcc ata gag cac ggt cag       1248
Thr Thr Ile Asn Ala Ile Val Ile Glu Glu Ala Ile Glu His Gly Gln           
                405                 410                 415               

cgc atc gag cat ctg cgc gtc acg ggt gcg ctg cct gac ggc acc gag       1296
Arg Ile Glu His Leu Arg Val Thr Gly Ala Leu Pro Asp Gly Thr Glu           
            420                 425                 430                   

cgc gtg ctc ggc cag gcc ggc acg gtg ggt tac cgg agg ata ctc cgc       1344
Arg Val Leu Gly Gln Ala Gly Thr Val Gly Tyr Arg Arg Ile Leu Arg           
        435                 440                 445                       

ttc gac gat gtc gag gtg tcc tcg gtc acc ctt cac gtg gac ggt tcg       1392
Phe Asp Asp Val Glu Val Ser Ser Val Thr Leu His Val Asp Gly Ser           
    450                 455                 460                           

agg ctt gcg ccg atg atc agc cgc gcg gct gcc gtg cgc atc tga           1437
Arg Leu Ala Pro Met Ile Ser Arg Ala Ala Ala Val Arg Ile                   
465                 470                 475                               


<210>  16
<211>  478
<212>  PRT
<213>  Bifidobacterium

<400>  16

Met Asn Asn Pro Ala Asp Ala Gly Ile Asn Leu Asn Tyr Leu Ala Asn 
1               5                   10                  15      


Val Arg Pro Ser Ser Arg Gln Leu Ala Trp Gln Arg Met Glu Met Tyr 
            20                  25                  30          


Ala Phe Leu His Phe Gly Met Asn Thr Met Thr Asp Arg Glu Trp Gly 
        35                  40                  45              


Leu Gly His Glu Asp Pro Ala Leu Phe Asn Pro Arg Asn Val Asp Val 
    50                  55                  60                  


Asp Gln Trp Met Asp Ala Leu Val Ala Gly Gly Met Ala Gly Val Ile 
65                  70                  75                  80  


Leu Thr Cys Lys His His Asp Gly Phe Cys Leu Trp Pro Ser Arg Leu 
                85                  90                  95      


Thr Arg His Thr Val Ala Ser Ser Pro Trp Arg Glu Gly Lys Gly Asp 
            100                 105                 110         


Leu Val Arg Glu Val Ser Glu Ser Ala Arg Arg His Gly Leu Lys Phe 
        115                 120                 125             


Gly Val Tyr Leu Ser Pro Trp Asp Arg Thr Glu Glu Ser Tyr Gly Lys 
    130                 135                 140                 


Gly Lys Ala Tyr Asp Asp Phe Tyr Val Gly Gln Leu Thr Glu Leu Leu 
145                 150                 155                 160 


Thr Gln Tyr Gly Pro Ile Phe Ser Val Trp Leu Asp Gly Ala Asn Gly 
                165                 170                 175     


Glu Gly Lys Asn Gly Lys Thr Gln Tyr Tyr Asp Trp Asp Arg Tyr Tyr 
            180                 185                 190         


Asn Val Ile Arg Ser Leu Gln Pro Asp Ala Val Ile Ser Val Cys Gly 
        195                 200                 205             


Pro Asp Val Arg Trp Ala Gly Asn Glu Ala Gly His Val Arg Asp Asn 
    210                 215                 220                 


Glu Trp Ser Val Val Pro Arg Arg Leu Arg Ser Ala Glu Leu Thr Met 
225                 230                 235                 240 


Glu Lys Ser Gln Gln Glu Asp Asp Ala Ser Phe Ala Thr Thr Val Ser 
                245                 250                 255     


Ser Gln Asp Asp Asp Leu Gly Ser Arg Glu Ala Val Ala Gly Tyr Gly 
            260                 265                 270         


Asp Asn Val Cys Trp Tyr Pro Ala Glu Val Asp Thr Ser Ile Arg Pro 
        275                 280                 285             


Gly Trp Phe Tyr His Gln Ser Glu Asp Asp Lys Val Met Ser Ala Asp 
    290                 295                 300                 


Gln Leu Phe Asp Leu Trp Leu Ser Ala Val Gly Gly Asn Ser Ser Leu 
305                 310                 315                 320 


Leu Leu Asn Ile Pro Pro Ser Pro Glu Gly Leu Leu Ala Glu Pro Asp 
                325                 330                 335     


Val Gln Ser Leu Lys Gly Leu Gly Arg Arg Val Ser Glu Phe Arg Glu 
            340                 345                 350         


Ala Leu Ala Ser Val Arg Cys Glu Ala Arg Thr Ser Ser Ala Ser Ala 
        355                 360                 365             


Ala Ala Ala His Leu Val Asp Gly Asn Arg Asp Thr Phe Trp Arg Pro 
    370                 375                 380                 


Asp Ala Asp Asp Ala Ala Pro Ala Ile Thr Leu Thr Leu Pro Gln Pro 
385                 390                 395                 400 


Thr Thr Ile Asn Ala Ile Val Ile Glu Glu Ala Ile Glu His Gly Gln 
                405                 410                 415     


Arg Ile Glu His Leu Arg Val Thr Gly Ala Leu Pro Asp Gly Thr Glu 
            420                 425                 430         


Arg Val Leu Gly Gln Ala Gly Thr Val Gly Tyr Arg Arg Ile Leu Arg 
        435                 440                 445             


Phe Asp Asp Val Glu Val Ser Ser Val Thr Leu His Val Asp Gly Ser 
    450                 455                 460                 


Arg Leu Ala Pro Met Ile Ser Arg Ala Ala Ala Val Arg Ile 
465                 470                 475             


<210>  17
<211>  2349
<212>  DNA
<213>  Bifidobacterium


<220>
<221>  CDS
<222>  (1)..(2349)
<223>  gene encoding 1,2-fucosidase (inf_2335)

<400>  17
atg aaa ctc act ttc gat ggg att tct tcg cat tgg gag gaa gga atc         48
Met Lys Leu Thr Phe Asp Gly Ile Ser Ser His Trp Glu Glu Gly Ile           
1               5                   10                  15                

ccg ttc ggc aac ggt cgc atg ggg gcg gtc ctg tgc tcc gaa ccg gac         96
Pro Phe Gly Asn Gly Arg Met Gly Ala Val Leu Cys Ser Glu Pro Asp           
            20                  25                  30                    

gcg gat gtg ctg tac ctc aac gac gac acc ctc tgg tcg ggc tat ccg        144
Ala Asp Val Leu Tyr Leu Asn Asp Asp Thr Leu Trp Ser Gly Tyr Pro           
        35                  40                  45                        

cat gcg gag acc tcg ccg ttg acg ccc gaa atc gtg gcc aaa gcc cgt        192
His Ala Glu Thr Ser Pro Leu Thr Pro Glu Ile Val Ala Lys Ala Arg           
    50                  55                  60                            

cag gcg tcg tct cgc ggc gat tac gtg tcg gcc acg cgg atc atc cag        240
Gln Ala Ser Ser Arg Gly Asp Tyr Val Ser Ala Thr Arg Ile Ile Gln           
65                  70                  75                  80            

gac gcc acg cag cgg gag aag gac gag cag ata tac gag ccg ttc ggc        288
Asp Ala Thr Gln Arg Glu Lys Asp Glu Gln Ile Tyr Glu Pro Phe Gly           
                85                  90                  95                

acg gct tgc atc cgg tac tcg tcg gag gcc ggc gaa cgg aag cat gtg        336
Thr Ala Cys Ile Arg Tyr Ser Ser Glu Ala Gly Glu Arg Lys His Val           
            100                 105                 110                   

aag cgc agc ctg gac ctc gcc agg gcc ctc gcc ggc gaa tcg ttc cgg        384
Lys Arg Ser Leu Asp Leu Ala Arg Ala Leu Ala Gly Glu Ser Phe Arg           
        115                 120                 125                       

ctg ggc gcc gcc gac gtc cat gtc gac gca tgg tgc agc gct ccc gat        432
Leu Gly Ala Ala Asp Val His Val Asp Ala Trp Cys Ser Ala Pro Asp           
    130                 135                 140                           

gat ctg ctg gtg tat gag atg tcg tcg agc gcg ccg gtc gat gcg agc        480
Asp Leu Leu Val Tyr Glu Met Ser Ser Ser Ala Pro Val Asp Ala Ser           
145                 150                 155                 160           

gtg agc gtc acc ggc act ttt ctc aag cag acc cgg ata tcg tcg ggg        528
Val Ser Val Thr Gly Thr Phe Leu Lys Gln Thr Arg Ile Ser Ser Gly           
                165                 170                 175               

tct gat tcc gat gcg cgc cag gcc acc ctc gtc gtc atg ggg cag atg        576
Ser Asp Ser Asp Ala Arg Gln Ala Thr Leu Val Val Met Gly Gln Met           
            180                 185                 190                   

ccc gga ctc aat gtc gga tca ttg gcc cat gtc acc gat aat cca tgg        624
Pro Gly Leu Asn Val Gly Ser Leu Ala His Val Thr Asp Asn Pro Trp           
        195                 200                 205                       

gag gac gaa cgg gac ggc atc ggg atg gcg tat gcc ggc gcc ttc tcc        672
Glu Asp Glu Arg Asp Gly Ile Gly Met Ala Tyr Ala Gly Ala Phe Ser           
    210                 215                 220                           

ctc acc gtc acg ggc ggc gag atc acg gtg atc gat gat gtt ctg cag        720
Leu Thr Val Thr Gly Gly Glu Ile Thr Val Ile Asp Asp Val Leu Gln           
225                 230                 235                 240           

tgc tcg ggc gtc acc ggc ttg tcg ctt cgg ttc cgc agc ctg agc ggg        768
Cys Ser Gly Val Thr Gly Leu Ser Leu Arg Phe Arg Ser Leu Ser Gly           
                245                 250                 255               

ttc aag gga agc gcc gaa cag ccg gag cgg gac atg acg gtg ctc gcc        816
Phe Lys Gly Ser Ala Glu Gln Pro Glu Arg Asp Met Thr Val Leu Ala           
            260                 265                 270                   

gat cgg ctg ggc gag acc atc gcc gca tgg ccg tcc gat tcg cgg gcg        864
Asp Arg Leu Gly Glu Thr Ile Ala Ala Trp Pro Ser Asp Ser Arg Ala           
        275                 280                 285                       

atg ctt gac cgt cac gtc gcc gac tac cgc cgg ttc ttc gac cgg gtc        912
Met Leu Asp Arg His Val Ala Asp Tyr Arg Arg Phe Phe Asp Arg Val           
    290                 295                 300                           

ggc gtg cgt ctc ggc ccg gcc cat gac gac gat gag gag gtg ccg ttc        960
Gly Val Arg Leu Gly Pro Ala His Asp Asp Asp Glu Glu Val Pro Phe           
305                 310                 315                 320           

gcc gag atc ctg cgc tcc aag gag gat acg ccg cac cgt ctg gag acg       1008
Ala Glu Ile Leu Arg Ser Lys Glu Asp Thr Pro His Arg Leu Glu Thr           
                325                 330                 335               

ctc tcc gag gcg atg ttc gat ttc ggc cga tac ctg ctg atc tcc tcg       1056
Leu Ser Glu Ala Met Phe Asp Phe Gly Arg Tyr Leu Leu Ile Ser Ser           
            340                 345                 350                   

tcc agg ccg cat acc cag ccg tcg aat ctg cag gga atc tgg aac cat       1104
Ser Arg Pro His Thr Gln Pro Ser Asn Leu Gln Gly Ile Trp Asn His           
        355                 360                 365                       

aag gac ttc ccg aac tgg tat agc gcc tac acg acg aac atc aac atc       1152
Lys Asp Phe Pro Asn Trp Tyr Ser Ala Tyr Thr Thr Asn Ile Asn Ile           
    370                 375                 380                           

gag atg aac tat tgg atg acc ggc cca tgc gcc ctc aag gag ctc atc       1200
Glu Met Asn Tyr Trp Met Thr Gly Pro Cys Ala Leu Lys Glu Leu Ile           
385                 390                 395                 400           

gaa ccg ctc gtc gcc atg aac agg gag ctg ctg gaa ccg ggg cat gat       1248
Glu Pro Leu Val Ala Met Asn Arg Glu Leu Leu Glu Pro Gly His Asp           
                405                 410                 415               

gcg gcc ggc gcc atc ctc gga tgc ggt ggt tcc gcg gtc ttc cac aat       1296
Ala Ala Gly Ala Ile Leu Gly Cys Gly Gly Ser Ala Val Phe His Asn           
            420                 425                 430                   

gtc gat atc tgg cgc agg gcg ctg ccg gcg aac gga gag ccg acg tgg       1344
Val Asp Ile Trp Arg Arg Ala Leu Pro Ala Asn Gly Glu Pro Thr Trp           
        435                 440                 445                       

gcg ttc tgg ccg ttc ggc cag gcg tgg atg tgc cgg aac ctg ttc gat       1392
Ala Phe Trp Pro Phe Gly Gln Ala Trp Met Cys Arg Asn Leu Phe Asp           
    450                 455                 460                           

gag tac ctg ttc aac cag gat gag tcg tat ctg gct tcc atc tgg ccg       1440
Glu Tyr Leu Phe Asn Gln Asp Glu Ser Tyr Leu Ala Ser Ile Trp Pro           
465                 470                 475                 480           

atc atg cgg gac agc gcg cga ttc tgc atg gat ttt ctg tcg gat acg       1488
Ile Met Arg Asp Ser Ala Arg Phe Cys Met Asp Phe Leu Ser Asp Thr           
                485                 490                 495               

gaa cac ggt ctg gcc ccg gct ccg gcg aca tcg ccg gaa aac tac ttc       1536
Glu His Gly Leu Ala Pro Ala Pro Ala Thr Ser Pro Glu Asn Tyr Phe           
            500                 505                 510                   

gtc gtg gac ggc gaa acg atc gcc gtc gcc cac acc agc gaa aac acc       1584
Val Val Asp Gly Glu Thr Ile Ala Val Ala His Thr Ser Glu Asn Thr           
        515                 520                 525                       

acg gcc atc gtg cgc aat ctg ctc gat gat ctg atc cac gcg gcg caa       1632
Thr Ala Ile Val Arg Asn Leu Leu Asp Asp Leu Ile His Ala Ala Gln           
    530                 535                 540                           

acc atg ccc gac ctg gat gac ggc gac aag gcc ttg gtg cgg gag gcg       1680
Thr Met Pro Asp Leu Asp Asp Gly Asp Lys Ala Leu Val Arg Glu Ala           
545                 550                 555                 560           

gaa tcc acc cgc gcg aag ctg gcg gct gtc cgc gtg gga tcc gat ggc       1728
Glu Ser Thr Arg Ala Lys Leu Ala Ala Val Arg Val Gly Ser Asp Gly           
                565                 570                 575               

agg att ctc gaa tgg aac gat gaa ctc gtc gag gcg gat ccg cat cac       1776
Arg Ile Leu Glu Trp Asn Asp Glu Leu Val Glu Ala Asp Pro His His           
            580                 585                 590                   

cgt cac ctg tcc cac ctg tac gaa ctg cat ccg ggc gca ggc atc acc       1824
Arg His Leu Ser His Leu Tyr Glu Leu His Pro Gly Ala Gly Ile Thr           
        595                 600                 605                       

gcg aac acc ccg cgt ctg gag gag gcc gcc agg aag tcc ctc gaa gtg       1872
Ala Asn Thr Pro Arg Leu Glu Glu Ala Ala Arg Lys Ser Leu Glu Val           
    610                 615                 620                           

cgt ggc gac gac ggt tcc ggc tgg agc atc gtg tgg cgc atg atc atg       1920
Arg Gly Asp Asp Gly Ser Gly Trp Ser Ile Val Trp Arg Met Ile Met           
625                 630                 635                 640           

tgg gcg cgt ctg cgg gac gct gag cac gcc gaa cgc atc atc ggc atg       1968
Trp Ala Arg Leu Arg Asp Ala Glu His Ala Glu Arg Ile Ile Gly Met           
                645                 650                 655               

ttc ctc cgc ccg gtc gaa gcc gac gcc gaa acc gat ctg ctt ggc ggc       2016
Phe Leu Arg Pro Val Glu Ala Asp Ala Glu Thr Asp Leu Leu Gly Gly           
            660                 665                 670                   

ggc gtg tat gcc agc ggc atg tgc gcg cat ccc cca ttc cag atc gac       2064
Gly Val Tyr Ala Ser Gly Met Cys Ala His Pro Pro Phe Gln Ile Asp           
        675                 680                 685                       

ggc aat ctg ggc ttc ccc gcg gct ctg gcg gag atg ctc gtc cag agt       2112
Gly Asn Leu Gly Phe Pro Ala Ala Leu Ala Glu Met Leu Val Gln Ser           
    690                 695                 700                           

cat gac ggc atg gtg cgc atc ctg ccc gcg ttg ccc gag gat tgg cat       2160
His Asp Gly Met Val Arg Ile Leu Pro Ala Leu Pro Glu Asp Trp His           
705                 710                 715                 720           

gaa ggc agc ttc cat ggc ctg cgc gcc agg gga ggc ctt tcg gtg gac       2208
Glu Gly Ser Phe His Gly Leu Arg Ala Arg Gly Gly Leu Ser Val Asp           
                725                 730                 735               

gcc tcc tgg acg gac gac gcc atc gaa tac acg ctg cgc tgc acg aag       2256
Ala Ser Trp Thr Asp Asp Ala Ile Glu Tyr Thr Leu Arg Cys Thr Lys           
            740                 745                 750                   

ccc gcg acg atc acc ctg atc gtc gat ggc acc gac gcg acg cag gtc       2304
Pro Ala Thr Ile Thr Leu Ile Val Asp Gly Thr Asp Ala Thr Gln Val           
        755                 760                 765                       

cga ctg tct ccc gac gag ccg ttc aag ggg ctt gtc cgc agg tag           2349
Arg Leu Ser Pro Asp Glu Pro Phe Lys Gly Leu Val Arg Arg                   
    770                 775                 780                           


<210>  18
<211>  782
<212>  PRT
<213>  Bifidobacterium

<400>  18

Met Lys Leu Thr Phe Asp Gly Ile Ser Ser His Trp Glu Glu Gly Ile 
1               5                   10                  15      


Pro Phe Gly Asn Gly Arg Met Gly Ala Val Leu Cys Ser Glu Pro Asp 
            20                  25                  30          


Ala Asp Val Leu Tyr Leu Asn Asp Asp Thr Leu Trp Ser Gly Tyr Pro 
        35                  40                  45              


His Ala Glu Thr Ser Pro Leu Thr Pro Glu Ile Val Ala Lys Ala Arg 
    50                  55                  60                  


Gln Ala Ser Ser Arg Gly Asp Tyr Val Ser Ala Thr Arg Ile Ile Gln 
65                  70                  75                  80  


Asp Ala Thr Gln Arg Glu Lys Asp Glu Gln Ile Tyr Glu Pro Phe Gly 
                85                  90                  95      


Thr Ala Cys Ile Arg Tyr Ser Ser Glu Ala Gly Glu Arg Lys His Val 
            100                 105                 110         


Lys Arg Ser Leu Asp Leu Ala Arg Ala Leu Ala Gly Glu Ser Phe Arg 
        115                 120                 125             


Leu Gly Ala Ala Asp Val His Val Asp Ala Trp Cys Ser Ala Pro Asp 
    130                 135                 140                 


Asp Leu Leu Val Tyr Glu Met Ser Ser Ser Ala Pro Val Asp Ala Ser 
145                 150                 155                 160 


Val Ser Val Thr Gly Thr Phe Leu Lys Gln Thr Arg Ile Ser Ser Gly 
                165                 170                 175     


Ser Asp Ser Asp Ala Arg Gln Ala Thr Leu Val Val Met Gly Gln Met 
            180                 185                 190         


Pro Gly Leu Asn Val Gly Ser Leu Ala His Val Thr Asp Asn Pro Trp 
        195                 200                 205             


Glu Asp Glu Arg Asp Gly Ile Gly Met Ala Tyr Ala Gly Ala Phe Ser 
    210                 215                 220                 


Leu Thr Val Thr Gly Gly Glu Ile Thr Val Ile Asp Asp Val Leu Gln 
225                 230                 235                 240 


Cys Ser Gly Val Thr Gly Leu Ser Leu Arg Phe Arg Ser Leu Ser Gly 
                245                 250                 255     


Phe Lys Gly Ser Ala Glu Gln Pro Glu Arg Asp Met Thr Val Leu Ala 
            260                 265                 270         


Asp Arg Leu Gly Glu Thr Ile Ala Ala Trp Pro Ser Asp Ser Arg Ala 
        275                 280                 285             


Met Leu Asp Arg His Val Ala Asp Tyr Arg Arg Phe Phe Asp Arg Val 
    290                 295                 300                 


Gly Val Arg Leu Gly Pro Ala His Asp Asp Asp Glu Glu Val Pro Phe 
305                 310                 315                 320 


Ala Glu Ile Leu Arg Ser Lys Glu Asp Thr Pro His Arg Leu Glu Thr 
                325                 330                 335     


Leu Ser Glu Ala Met Phe Asp Phe Gly Arg Tyr Leu Leu Ile Ser Ser 
            340                 345                 350         


Ser Arg Pro His Thr Gln Pro Ser Asn Leu Gln Gly Ile Trp Asn His 
        355                 360                 365             


Lys Asp Phe Pro Asn Trp Tyr Ser Ala Tyr Thr Thr Asn Ile Asn Ile 
    370                 375                 380                 


Glu Met Asn Tyr Trp Met Thr Gly Pro Cys Ala Leu Lys Glu Leu Ile 
385                 390                 395                 400 


Glu Pro Leu Val Ala Met Asn Arg Glu Leu Leu Glu Pro Gly His Asp 
                405                 410                 415     


Ala Ala Gly Ala Ile Leu Gly Cys Gly Gly Ser Ala Val Phe His Asn 
            420                 425                 430         


Val Asp Ile Trp Arg Arg Ala Leu Pro Ala Asn Gly Glu Pro Thr Trp 
        435                 440                 445             


Ala Phe Trp Pro Phe Gly Gln Ala Trp Met Cys Arg Asn Leu Phe Asp 
    450                 455                 460                 


Glu Tyr Leu Phe Asn Gln Asp Glu Ser Tyr Leu Ala Ser Ile Trp Pro 
465                 470                 475                 480 


Ile Met Arg Asp Ser Ala Arg Phe Cys Met Asp Phe Leu Ser Asp Thr 
                485                 490                 495     


Glu His Gly Leu Ala Pro Ala Pro Ala Thr Ser Pro Glu Asn Tyr Phe 
            500                 505                 510         


Val Val Asp Gly Glu Thr Ile Ala Val Ala His Thr Ser Glu Asn Thr 
        515                 520                 525             


Thr Ala Ile Val Arg Asn Leu Leu Asp Asp Leu Ile His Ala Ala Gln 
    530                 535                 540                 


Thr Met Pro Asp Leu Asp Asp Gly Asp Lys Ala Leu Val Arg Glu Ala 
545                 550                 555                 560 


Glu Ser Thr Arg Ala Lys Leu Ala Ala Val Arg Val Gly Ser Asp Gly 
                565                 570                 575     


Arg Ile Leu Glu Trp Asn Asp Glu Leu Val Glu Ala Asp Pro His His 
            580                 585                 590         


Arg His Leu Ser His Leu Tyr Glu Leu His Pro Gly Ala Gly Ile Thr 
        595                 600                 605             


Ala Asn Thr Pro Arg Leu Glu Glu Ala Ala Arg Lys Ser Leu Glu Val 
    610                 615                 620                 


Arg Gly Asp Asp Gly Ser Gly Trp Ser Ile Val Trp Arg Met Ile Met 
625                 630                 635                 640 


Trp Ala Arg Leu Arg Asp Ala Glu His Ala Glu Arg Ile Ile Gly Met 
                645                 650                 655     


Phe Leu Arg Pro Val Glu Ala Asp Ala Glu Thr Asp Leu Leu Gly Gly 
            660                 665                 670         


Gly Val Tyr Ala Ser Gly Met Cys Ala His Pro Pro Phe Gln Ile Asp 
        675                 680                 685             


Gly Asn Leu Gly Phe Pro Ala Ala Leu Ala Glu Met Leu Val Gln Ser 
    690                 695                 700                 


His Asp Gly Met Val Arg Ile Leu Pro Ala Leu Pro Glu Asp Trp His 
705                 710                 715                 720 


Glu Gly Ser Phe His Gly Leu Arg Ala Arg Gly Gly Leu Ser Val Asp 
                725                 730                 735     


Ala Ser Trp Thr Asp Asp Ala Ile Glu Tyr Thr Leu Arg Cys Thr Lys 
            740                 745                 750         


Pro Ala Thr Ile Thr Leu Ile Val Asp Gly Thr Asp Ala Thr Gln Val 
        755                 760                 765             


Arg Leu Ser Pro Asp Glu Pro Phe Lys Gly Leu Val Arg Arg 
    770                 775                 780         


<210>  19
<211>  1506
<212>  DNA
<213>  Lactobacillus plantarum


<220>
<221>  CDS
<222>  (1)..(1506)
<223>  gene encoding beta-fructofuranosidase from Lactobacillus 
       plantarum

<400>  19
atg ata tgg aat cgt aaa acc cgt tat acc cct tat gaa cag tgg cca         48
Met Ile Trp Asn Arg Lys Thr Arg Tyr Thr Pro Tyr Glu Gln Trp Pro           
1               5                   10                  15                

gca act aag cta cca cag ctc gtt gcc cag gca cgc cag tct aag tgg         96
Ala Thr Lys Leu Pro Gln Leu Val Ala Gln Ala Arg Gln Ser Lys Trp           
            20                  25                  30                    

cgg atg caa cat cat att cag cct aca tca ggt ttg tta aat gac ccc        144
Arg Met Gln His His Ile Gln Pro Thr Ser Gly Leu Leu Asn Asp Pro           
        35                  40                  45                        

aat ggc ttt tca tac ttt gat ggt cag tgg cac ctg ttc tac caa gtc        192
Asn Gly Phe Ser Tyr Phe Asp Gly Gln Trp His Leu Phe Tyr Gln Val           
    50                  55                  60                            

ttt ccg ttc ggt ccg gta cac gga ctg aag tca tgg caa cac gtg acc        240
Phe Pro Phe Gly Pro Val His Gly Leu Lys Ser Trp Gln His Val Thr           
65                  70                  75                  80            

tct aag aac ttg gtg gat tgg cat gat gag ggc tta gcg att cga cca        288
Ser Lys Asn Leu Val Asp Trp His Asp Glu Gly Leu Ala Ile Arg Pro           
                85                  90                  95                

gat acg cca tac gac tca cac ggc gcg tac acg ggt aca gca cta cca        336
Asp Thr Pro Tyr Asp Ser His Gly Ala Tyr Thr Gly Thr Ala Leu Pro           
            100                 105                 110                   

att gat gat cag tta ttt att atg tat acg ggt aat gtc cgt act gcc        384
Ile Asp Asp Gln Leu Phe Ile Met Tyr Thr Gly Asn Val Arg Thr Ala           
        115                 120                 125                       

gac tgg caa cgt gaa tcg tat caa tta ggt gcc tgg atg gac acg gat        432
Asp Trp Gln Arg Glu Ser Tyr Gln Leu Gly Ala Trp Met Asp Thr Asp           
    130                 135                 140                           

aat cac att aaa aag ctg tcc cgg cca cta att gcg cat gct ccg gct        480
Asn His Ile Lys Lys Leu Ser Arg Pro Leu Ile Ala His Ala Pro Ala           
145                 150                 155                 160           

ggg tac acg agt tcg ttt cgt gat ccg gac ttg atc cgg act gac cac        528
Gly Tyr Thr Ser Ser Phe Arg Asp Pro Asp Leu Ile Arg Thr Asp His           
                165                 170                 175               

ggc tac tac gcg cta atc ggt gcg cag acg act act gag atc ggt gct        576
Gly Tyr Tyr Ala Leu Ile Gly Ala Gln Thr Thr Thr Glu Ile Gly Ala           
            180                 185                 190                   

atc ttg gtt tat ttc tca aag gat ctg acc acc tgg acg tgt caa ggc        624
Ile Leu Val Tyr Phe Ser Lys Asp Leu Thr Thr Trp Thr Cys Gln Gly           
        195                 200                 205                       

gag ttg aac gtt ccc gca aat gcg cgg ggt tat atg att gag tgt cca        672
Glu Leu Asn Val Pro Ala Asn Ala Arg Gly Tyr Met Ile Glu Cys Pro           
    210                 215                 220                           

aat ctg gtc tgg atc gat caa cag ccc gtc tta ttg ttc tgt ccc caa        720
Asn Leu Val Trp Ile Asp Gln Gln Pro Val Leu Leu Phe Cys Pro Gln           
225                 230                 235                 240           

ggg tta tca caa aca acg acc ccg tat cag aat att tat ccg aac atg        768
Gly Leu Ser Gln Thr Thr Thr Pro Tyr Gln Asn Ile Tyr Pro Asn Met           
                245                 250                 255               

tac cta gtt gcc gat caa ttg gat ctg gct cag gca caa ttc act gaa        816
Tyr Leu Val Ala Asp Gln Leu Asp Leu Ala Gln Ala Gln Phe Thr Glu           
            260                 265                 270                   

ccc cac gcc ctg acg caa tta gat gat ggc ttt gac gtg tat gcc acg        864
Pro His Ala Leu Thr Gln Leu Asp Asp Gly Phe Asp Val Tyr Ala Thr           
        275                 280                 285                       

cag gca atc aat gcg ccg gat ggc cgc gcg tta gcc gtt agc tgg att        912
Gln Ala Ile Asn Ala Pro Asp Gly Arg Ala Leu Ala Val Ser Trp Ile           
    290                 295                 300                           

ggg tta cct gaa att gcc tat cca act gat cgt gaa aat tgg gcc cat        960
Gly Leu Pro Glu Ile Ala Tyr Pro Thr Asp Arg Glu Asn Trp Ala His           
305                 310                 315                 320           

tgt ttg agc tta gtt aag gaa cta acg ctt aaa gat ggg cac ctc tat       1008
Cys Leu Ser Leu Val Lys Glu Leu Thr Leu Lys Asp Gly His Leu Tyr           
                325                 330                 335               

caa aat cca gtg gca gcg gtg gat gat ttg cgg atg acg gcg cat gac       1056
Gln Asn Pro Val Ala Ala Val Asp Asp Leu Arg Met Thr Ala His Asp           
            340                 345                 350                   

cta gtc ttt gag caa caa cgg gcg acg gtg gcc gct ttg aat ggc agc       1104
Leu Val Phe Glu Gln Gln Arg Ala Thr Val Ala Ala Leu Asn Gly Ser           
        355                 360                 365                       

ttt gaa ctc tta ctg acg gtt ccc gct gat aaa acg gtc acg gtt aac       1152
Phe Glu Leu Leu Leu Thr Val Pro Ala Asp Lys Thr Val Thr Val Asn           
    370                 375                 380                           

att gct gat cag cag gaa agt ggc cag ctg cag gtg act gtt gat gcc       1200
Ile Ala Asp Gln Gln Glu Ser Gly Gln Leu Gln Val Thr Val Asp Ala           
385                 390                 395                 400           

aac cat ggt cag gtt atg att gat cgg cgg cat acg ggg aat tcg ttt       1248
Asn His Gly Gln Val Met Ile Asp Arg Arg His Thr Gly Asn Ser Phe           
                405                 410                 415               

gct gaa gat tat ggt cag act cgt caa gtt gag tta acg gcc cat aag       1296
Ala Glu Asp Tyr Gly Gln Thr Arg Gln Val Glu Leu Thr Ala His Lys           
            420                 425                 430                   

acg ata aaa atc cgg cta atc ata gat gtg tca gtc ttt gaa tgc tat       1344
Thr Ile Lys Ile Arg Leu Ile Ile Asp Val Ser Val Phe Glu Cys Tyr           
        435                 440                 445                       

att gat aat ggc tat tcc gtg atg acc ggc cgt ttc ttc tta aac gct       1392
Ile Asp Asn Gly Tyr Ser Val Met Thr Gly Arg Phe Phe Leu Asn Ala           
    450                 455                 460                           

acc ccg agt cgc ctt aac gtt caa ggt gac act acg gca gtt acc ggt       1440
Thr Pro Ser Arg Leu Asn Val Gln Gly Asp Thr Thr Ala Val Thr Gly           
465                 470                 475                 480           

aaa gtc tgg gaa tgg cgc caa tca gag cat act gga gtc gat aac aat       1488
Lys Val Trp Glu Trp Arg Gln Ser Glu His Thr Gly Val Asp Asn Asn           
                485                 490                 495               

gaa acc aaa att aaa tga                                               1506
Glu Thr Lys Ile Lys                                                       
            500                                                           


<210>  20
<211>  501
<212>  PRT
<213>  Lactobacillus plantarum

<400>  20

Met Ile Trp Asn Arg Lys Thr Arg Tyr Thr Pro Tyr Glu Gln Trp Pro 
1               5                   10                  15      


Ala Thr Lys Leu Pro Gln Leu Val Ala Gln Ala Arg Gln Ser Lys Trp 
            20                  25                  30          


Arg Met Gln His His Ile Gln Pro Thr Ser Gly Leu Leu Asn Asp Pro 
        35                  40                  45              


Asn Gly Phe Ser Tyr Phe Asp Gly Gln Trp His Leu Phe Tyr Gln Val 
    50                  55                  60                  


Phe Pro Phe Gly Pro Val His Gly Leu Lys Ser Trp Gln His Val Thr 
65                  70                  75                  80  


Ser Lys Asn Leu Val Asp Trp His Asp Glu Gly Leu Ala Ile Arg Pro 
                85                  90                  95      


Asp Thr Pro Tyr Asp Ser His Gly Ala Tyr Thr Gly Thr Ala Leu Pro 
            100                 105                 110         


Ile Asp Asp Gln Leu Phe Ile Met Tyr Thr Gly Asn Val Arg Thr Ala 
        115                 120                 125             


Asp Trp Gln Arg Glu Ser Tyr Gln Leu Gly Ala Trp Met Asp Thr Asp 
    130                 135                 140                 


Asn His Ile Lys Lys Leu Ser Arg Pro Leu Ile Ala His Ala Pro Ala 
145                 150                 155                 160 


Gly Tyr Thr Ser Ser Phe Arg Asp Pro Asp Leu Ile Arg Thr Asp His 
                165                 170                 175     


Gly Tyr Tyr Ala Leu Ile Gly Ala Gln Thr Thr Thr Glu Ile Gly Ala 
            180                 185                 190         


Ile Leu Val Tyr Phe Ser Lys Asp Leu Thr Thr Trp Thr Cys Gln Gly 
        195                 200                 205             


Glu Leu Asn Val Pro Ala Asn Ala Arg Gly Tyr Met Ile Glu Cys Pro 
    210                 215                 220                 


Asn Leu Val Trp Ile Asp Gln Gln Pro Val Leu Leu Phe Cys Pro Gln 
225                 230                 235                 240 


Gly Leu Ser Gln Thr Thr Thr Pro Tyr Gln Asn Ile Tyr Pro Asn Met 
                245                 250                 255     


Tyr Leu Val Ala Asp Gln Leu Asp Leu Ala Gln Ala Gln Phe Thr Glu 
            260                 265                 270         


Pro His Ala Leu Thr Gln Leu Asp Asp Gly Phe Asp Val Tyr Ala Thr 
        275                 280                 285             


Gln Ala Ile Asn Ala Pro Asp Gly Arg Ala Leu Ala Val Ser Trp Ile 
    290                 295                 300                 


Gly Leu Pro Glu Ile Ala Tyr Pro Thr Asp Arg Glu Asn Trp Ala His 
305                 310                 315                 320 


Cys Leu Ser Leu Val Lys Glu Leu Thr Leu Lys Asp Gly His Leu Tyr 
                325                 330                 335     


Gln Asn Pro Val Ala Ala Val Asp Asp Leu Arg Met Thr Ala His Asp 
            340                 345                 350         


Leu Val Phe Glu Gln Gln Arg Ala Thr Val Ala Ala Leu Asn Gly Ser 
        355                 360                 365             


Phe Glu Leu Leu Leu Thr Val Pro Ala Asp Lys Thr Val Thr Val Asn 
    370                 375                 380                 


Ile Ala Asp Gln Gln Glu Ser Gly Gln Leu Gln Val Thr Val Asp Ala 
385                 390                 395                 400 


Asn His Gly Gln Val Met Ile Asp Arg Arg His Thr Gly Asn Ser Phe 
                405                 410                 415     


Ala Glu Asp Tyr Gly Gln Thr Arg Gln Val Glu Leu Thr Ala His Lys 
            420                 425                 430         


Thr Ile Lys Ile Arg Leu Ile Ile Asp Val Ser Val Phe Glu Cys Tyr 
        435                 440                 445             


Ile Asp Asn Gly Tyr Ser Val Met Thr Gly Arg Phe Phe Leu Asn Ala 
    450                 455                 460                 


Thr Pro Ser Arg Leu Asn Val Gln Gly Asp Thr Thr Ala Val Thr Gly 
465                 470                 475                 480 


Lys Val Trp Glu Trp Arg Gln Ser Glu His Thr Gly Val Asp Asn Asn 
                485                 490                 495     


Glu Thr Lys Ile Lys 
            500     


<210>  21
<211>  117
<212>  DNA
<213>  E. coli


<220>
<221>  sig_peptide
<222>  (1)..(117)
<223>  torA signal peptide

<400>  21
atgaacaata acgatctctt tcaggcatca cgtcggcgtt ttctggcaca actcggcggc       60

ttaaccgtcg ccgggatgct ggggccgtca ttgttaacgc cgcgacgtgc gactgcg         117


<210>  22
<211>  1434
<212>  DNA
<213>  E. coli


<220>
<221>  CDS
<222>  (1)..(1434)
<223>  gene encoding glycogen synthase glgA

<400>  22
atg cag gtt tta cat gta tgt tca gag atg ttc ccg ctg ctt aaa acc         48
Met Gln Val Leu His Val Cys Ser Glu Met Phe Pro Leu Leu Lys Thr           
1               5                   10                  15                

ggc ggt ctg gct gat gtt att ggg gca tta ccc gca gca caa atc gca         96
Gly Gly Leu Ala Asp Val Ile Gly Ala Leu Pro Ala Ala Gln Ile Ala           
            20                  25                  30                    

gac ggc gtt gac gct cgc gta ctg ttg cct gca ttt ccc gat att cgc        144
Asp Gly Val Asp Ala Arg Val Leu Leu Pro Ala Phe Pro Asp Ile Arg           
        35                  40                  45                        

cgt ggc gtg acc gat gcg cag gta gta tcc cgt cgt gat acc ttc gcc        192
Arg Gly Val Thr Asp Ala Gln Val Val Ser Arg Arg Asp Thr Phe Ala           
    50                  55                  60                            

gga cat atc acg ctg ttg ttc ggt cat tac aac ggg gtt ggc ata tac        240
Gly His Ile Thr Leu Leu Phe Gly His Tyr Asn Gly Val Gly Ile Tyr           
65                  70                  75                  80            

ctg att gac gcg ccg cat ctc tat gat cgt ccg gga agc ccg tat cac        288
Leu Ile Asp Ala Pro His Leu Tyr Asp Arg Pro Gly Ser Pro Tyr His           
                85                  90                  95                

gat acc aac tta ttt gcc tat acc gac aac gta ttg cgt ttt gcg ctg        336
Asp Thr Asn Leu Phe Ala Tyr Thr Asp Asn Val Leu Arg Phe Ala Leu           
            100                 105                 110                   

ctg ggg tgg gtt ggg gca gaa atg gcc agc ggg ctt gac cca ttc tgg        384
Leu Gly Trp Val Gly Ala Glu Met Ala Ser Gly Leu Asp Pro Phe Trp           
        115                 120                 125                       

cgt cct gat gtg gtg cat gcg cac gac tgg cat gca ggc ctt gcg cct        432
Arg Pro Asp Val Val His Ala His Asp Trp His Ala Gly Leu Ala Pro           
    130                 135                 140                           

gcg tat ctg gcg gcg cgc ggg cgt ccg gcg aag tcg gtg ttt act gtg        480
Ala Tyr Leu Ala Ala Arg Gly Arg Pro Ala Lys Ser Val Phe Thr Val           
145                 150                 155                 160           

cac aac ctg gcc tat caa ggc atg ttt tat gca cat cac atg aat gac        528
His Asn Leu Ala Tyr Gln Gly Met Phe Tyr Ala His His Met Asn Asp           
                165                 170                 175               

atc caa ttg cca tgg tca ttc ttt aat att cat ggg ctg gaa ttc aac        576
Ile Gln Leu Pro Trp Ser Phe Phe Asn Ile His Gly Leu Glu Phe Asn           
            180                 185                 190                   

gga caa atc tct ttc ctg aag gcc ggt ctg tac tat gcc gat cac att        624
Gly Gln Ile Ser Phe Leu Lys Ala Gly Leu Tyr Tyr Ala Asp His Ile           
        195                 200                 205                       

acg gca gtc agc cca acc tac gct cgc gag atc acc gaa ccg cag ttt        672
Thr Ala Val Ser Pro Thr Tyr Ala Arg Glu Ile Thr Glu Pro Gln Phe           
    210                 215                 220                           

gcc tac ggt atg gaa ggt ctg ttg caa cag cgt cac cgt gaa ggg cgt        720
Ala Tyr Gly Met Glu Gly Leu Leu Gln Gln Arg His Arg Glu Gly Arg           
225                 230                 235                 240           

ctt tcc ggc gta ctg aac ggc gtg gac gag aaa atc tgg agt cca gag        768
Leu Ser Gly Val Leu Asn Gly Val Asp Glu Lys Ile Trp Ser Pro Glu           
                245                 250                 255               

acg gac tta ctg ttg gcc tcg cgt tac acc cgc gat acg ttg gaa gat        816
Thr Asp Leu Leu Leu Ala Ser Arg Tyr Thr Arg Asp Thr Leu Glu Asp           
            260                 265                 270                   

aaa gcg gaa aat aag cgc cag tta caa atc gca atg ggg ctt aag gtt        864
Lys Ala Glu Asn Lys Arg Gln Leu Gln Ile Ala Met Gly Leu Lys Val           
        275                 280                 285                       

gac gat aaa gtg ccg ctt ttt gca gtg gtg agc cgt ctt acc agc cag        912
Asp Asp Lys Val Pro Leu Phe Ala Val Val Ser Arg Leu Thr Ser Gln           
    290                 295                 300                           

aaa ggt ctc gac ctg gtg ctg gaa gcc tta cct ggt ctt ctg gag cag        960
Lys Gly Leu Asp Leu Val Leu Glu Ala Leu Pro Gly Leu Leu Glu Gln           
305                 310                 315                 320           

ggc ggg cag ctg gcg cta ctc ggc gcg ggc gat ccg gtg ctg cag gaa       1008
Gly Gly Gln Leu Ala Leu Leu Gly Ala Gly Asp Pro Val Leu Gln Glu           
                325                 330                 335               

ggt ttc ctt gcg gcg gca gcg gaa tac ccc ggc cag gtg ggc gtt cag       1056
Gly Phe Leu Ala Ala Ala Ala Glu Tyr Pro Gly Gln Val Gly Val Gln           
            340                 345                 350                   

att ggc tat cac gaa gca ttt tcg cat cgc att atg ggc ggc gcg gac       1104
Ile Gly Tyr His Glu Ala Phe Ser His Arg Ile Met Gly Gly Ala Asp           
        355                 360                 365                       

gtc att ctg gtg ccc agc cgt ttt gaa ccg tgc ggc tta acg caa ctt       1152
Val Ile Leu Val Pro Ser Arg Phe Glu Pro Cys Gly Leu Thr Gln Leu           
    370                 375                 380                           

tat gga ttg aag tac ggt acg ctg ccg tta gtg cgg cgc acc ggt ggg       1200
Tyr Gly Leu Lys Tyr Gly Thr Leu Pro Leu Val Arg Arg Thr Gly Gly           
385                 390                 395                 400           

ctt gct gat acg gtt tct gac tgt tct ctt gag aac ctt gca gat ggc       1248
Leu Ala Asp Thr Val Ser Asp Cys Ser Leu Glu Asn Leu Ala Asp Gly           
                405                 410                 415               

gtc gcc agt ggg ttt gtc ttt gaa gat agt aat gcc tgg tcg ctg tta       1296
Val Ala Ser Gly Phe Val Phe Glu Asp Ser Asn Ala Trp Ser Leu Leu           
            420                 425                 430                   

cgg gct att cga cgt gct ttt gta ctg tgg tcc cgt cct tca ctg tgg       1344
Arg Ala Ile Arg Arg Ala Phe Val Leu Trp Ser Arg Pro Ser Leu Trp           
        435                 440                 445                       

cgg ttt gtg caa cgt cag gct atg gca atg gat ttt agc tgg cag gtc       1392
Arg Phe Val Gln Arg Gln Ala Met Ala Met Asp Phe Ser Trp Gln Val           
    450                 455                 460                           

gcg gcg aag tcg tac cgt gag ctt tac tat cgc ttg aaa tag               1434
Ala Ala Lys Ser Tyr Arg Glu Leu Tyr Tyr Arg Leu Lys                       
465                 470                 475                               


<210>  23
<211>  477
<212>  PRT
<213>  E. coli

<400>  23

Met Gln Val Leu His Val Cys Ser Glu Met Phe Pro Leu Leu Lys Thr 
1               5                   10                  15      


Gly Gly Leu Ala Asp Val Ile Gly Ala Leu Pro Ala Ala Gln Ile Ala 
            20                  25                  30          


Asp Gly Val Asp Ala Arg Val Leu Leu Pro Ala Phe Pro Asp Ile Arg 
        35                  40                  45              


Arg Gly Val Thr Asp Ala Gln Val Val Ser Arg Arg Asp Thr Phe Ala 
    50                  55                  60                  


Gly His Ile Thr Leu Leu Phe Gly His Tyr Asn Gly Val Gly Ile Tyr 
65                  70                  75                  80  


Leu Ile Asp Ala Pro His Leu Tyr Asp Arg Pro Gly Ser Pro Tyr His 
                85                  90                  95      


Asp Thr Asn Leu Phe Ala Tyr Thr Asp Asn Val Leu Arg Phe Ala Leu 
            100                 105                 110         


Leu Gly Trp Val Gly Ala Glu Met Ala Ser Gly Leu Asp Pro Phe Trp 
        115                 120                 125             


Arg Pro Asp Val Val His Ala His Asp Trp His Ala Gly Leu Ala Pro 
    130                 135                 140                 


Ala Tyr Leu Ala Ala Arg Gly Arg Pro Ala Lys Ser Val Phe Thr Val 
145                 150                 155                 160 


His Asn Leu Ala Tyr Gln Gly Met Phe Tyr Ala His His Met Asn Asp 
                165                 170                 175     


Ile Gln Leu Pro Trp Ser Phe Phe Asn Ile His Gly Leu Glu Phe Asn 
            180                 185                 190         


Gly Gln Ile Ser Phe Leu Lys Ala Gly Leu Tyr Tyr Ala Asp His Ile 
        195                 200                 205             


Thr Ala Val Ser Pro Thr Tyr Ala Arg Glu Ile Thr Glu Pro Gln Phe 
    210                 215                 220                 


Ala Tyr Gly Met Glu Gly Leu Leu Gln Gln Arg His Arg Glu Gly Arg 
225                 230                 235                 240 


Leu Ser Gly Val Leu Asn Gly Val Asp Glu Lys Ile Trp Ser Pro Glu 
                245                 250                 255     


Thr Asp Leu Leu Leu Ala Ser Arg Tyr Thr Arg Asp Thr Leu Glu Asp 
            260                 265                 270         


Lys Ala Glu Asn Lys Arg Gln Leu Gln Ile Ala Met Gly Leu Lys Val 
        275                 280                 285             


Asp Asp Lys Val Pro Leu Phe Ala Val Val Ser Arg Leu Thr Ser Gln 
    290                 295                 300                 


Lys Gly Leu Asp Leu Val Leu Glu Ala Leu Pro Gly Leu Leu Glu Gln 
305                 310                 315                 320 


Gly Gly Gln Leu Ala Leu Leu Gly Ala Gly Asp Pro Val Leu Gln Glu 
                325                 330                 335     


Gly Phe Leu Ala Ala Ala Ala Glu Tyr Pro Gly Gln Val Gly Val Gln 
            340                 345                 350         


Ile Gly Tyr His Glu Ala Phe Ser His Arg Ile Met Gly Gly Ala Asp 
        355                 360                 365             


Val Ile Leu Val Pro Ser Arg Phe Glu Pro Cys Gly Leu Thr Gln Leu 
    370                 375                 380                 


Tyr Gly Leu Lys Tyr Gly Thr Leu Pro Leu Val Arg Arg Thr Gly Gly 
385                 390                 395                 400 


Leu Ala Asp Thr Val Ser Asp Cys Ser Leu Glu Asn Leu Ala Asp Gly 
                405                 410                 415     


Val Ala Ser Gly Phe Val Phe Glu Asp Ser Asn Ala Trp Ser Leu Leu 
            420                 425                 430         


Arg Ala Ile Arg Arg Ala Phe Val Leu Trp Ser Arg Pro Ser Leu Trp 
        435                 440                 445             


Arg Phe Val Gln Arg Gln Ala Met Ala Met Asp Phe Ser Trp Gln Val 
    450                 455                 460                 


Ala Ala Lys Ser Tyr Arg Glu Leu Tyr Tyr Arg Leu Lys 
465                 470                 475         


<210>  24
<211>  894
<212>  DNA
<213>  E. coli


<220>
<221>  CDS
<222>  (1)..(894)
<223>  gene encoding N-acetylneuraminate lyase  nanA

<400>  24
atg gca acg aat tta cgt ggc gta atg gct gca ctc ctg act cct ttt         48
Met Ala Thr Asn Leu Arg Gly Val Met Ala Ala Leu Leu Thr Pro Phe           
1               5                   10                  15                

gac caa caa caa gca ctg gat aaa gcg agt ctg cgc cgc ctg gtt cag         96
Asp Gln Gln Gln Ala Leu Asp Lys Ala Ser Leu Arg Arg Leu Val Gln           
            20                  25                  30                    

ttc aat att cag cag ggc atc gac ggt ttg tac gtg ggg ggt tcg aca        144
Phe Asn Ile Gln Gln Gly Ile Asp Gly Leu Tyr Val Gly Gly Ser Thr           
        35                  40                  45                        

ggc gaa gcc ttt gta cag agc ctt tca gag cgt gaa cag gta ctg gaa        192
Gly Glu Ala Phe Val Gln Ser Leu Ser Glu Arg Glu Gln Val Leu Glu           
    50                  55                  60                            

atc gtc gct gaa gag gcg aaa ggt aag att aaa ctc atc gcc cac gtc        240
Ile Val Ala Glu Glu Ala Lys Gly Lys Ile Lys Leu Ile Ala His Val           
65                  70                  75                  80            

ggt tgc gtc agc acc gcc gaa agc caa caa ctt gcg gca tcg gct aaa        288
Gly Cys Val Ser Thr Ala Glu Ser Gln Gln Leu Ala Ala Ser Ala Lys           
                85                  90                  95                

cgt tat ggc ttc gat gcc gtc tcc gcc gtc acg ccg ttc tac tat cct        336
Arg Tyr Gly Phe Asp Ala Val Ser Ala Val Thr Pro Phe Tyr Tyr Pro           
            100                 105                 110                   

ttc agc ttt gaa gaa cac tgc gat cac tat cgg gca att att gat tcg        384
Phe Ser Phe Glu Glu His Cys Asp His Tyr Arg Ala Ile Ile Asp Ser           
        115                 120                 125                       

gcg gat ggg ttg ccg atg gtg gtg tac aac att cca gcc ctg agc ggg        432
Ala Asp Gly Leu Pro Met Val Val Tyr Asn Ile Pro Ala Leu Ser Gly           
    130                 135                 140                           

gta aaa ctg acc ctg gat cag atc aac acc ctg gtt acg ctg cct ggt        480
Val Lys Leu Thr Leu Asp Gln Ile Asn Thr Leu Val Thr Leu Pro Gly           
145                 150                 155                 160           

gta ggt gcg ctg aaa cag acc tct ggc gat ctc tat cag atg gag cag        528
Val Gly Ala Leu Lys Gln Thr Ser Gly Asp Leu Tyr Gln Met Glu Gln           
                165                 170                 175               

atc cgt cgt gaa cat cct gat ctg gtg ctc tat aac ggt tac gac gaa        576
Ile Arg Arg Glu His Pro Asp Leu Val Leu Tyr Asn Gly Tyr Asp Glu           
            180                 185                 190                   

atc ttc gcc tct ggt ctt ctg gcg ggc gca gac ggc ggt atc ggc agc        624
Ile Phe Ala Ser Gly Leu Leu Ala Gly Ala Asp Gly Gly Ile Gly Ser           
        195                 200                 205                       

act tac aac atc atg ggc tgg cgt tat cag ggg atc gtg aag gcg ctg        672
Thr Tyr Asn Ile Met Gly Trp Arg Tyr Gln Gly Ile Val Lys Ala Leu           
    210                 215                 220                           

aaa gaa ggc gat atc cag acc gcg cag aaa ctg caa act gag tgc aac        720
Lys Glu Gly Asp Ile Gln Thr Ala Gln Lys Leu Gln Thr Glu Cys Asn           
225                 230                 235                 240           

aaa gtc att gat tta ctg atc aaa act ggc gta ttc cgc ggc ctg aaa        768
Lys Val Ile Asp Leu Leu Ile Lys Thr Gly Val Phe Arg Gly Leu Lys           
                245                 250                 255               

act gtc ctg cat tat atg gat gtc gtt tct gtg ccg ctg tgc cgc aaa        816
Thr Val Leu His Tyr Met Asp Val Val Ser Val Pro Leu Cys Arg Lys           
            260                 265                 270                   

ccg ttt ggt ccg gta gat gaa aaa tat ctg cca gaa ctg aag gcg ctg        864
Pro Phe Gly Pro Val Asp Glu Lys Tyr Leu Pro Glu Leu Lys Ala Leu           
        275                 280                 285                       

gcc cag cag ttg atg caa gag cgc ggg tga                                894
Ala Gln Gln Leu Met Gln Glu Arg Gly                                       
    290                 295                                               


<210>  25
<211>  297
<212>  PRT
<213>  E. coli

<400>  25

Met Ala Thr Asn Leu Arg Gly Val Met Ala Ala Leu Leu Thr Pro Phe 
1               5                   10                  15      


Asp Gln Gln Gln Ala Leu Asp Lys Ala Ser Leu Arg Arg Leu Val Gln 
            20                  25                  30          


Phe Asn Ile Gln Gln Gly Ile Asp Gly Leu Tyr Val Gly Gly Ser Thr 
        35                  40                  45              


Gly Glu Ala Phe Val Gln Ser Leu Ser Glu Arg Glu Gln Val Leu Glu 
    50                  55                  60                  


Ile Val Ala Glu Glu Ala Lys Gly Lys Ile Lys Leu Ile Ala His Val 
65                  70                  75                  80  


Gly Cys Val Ser Thr Ala Glu Ser Gln Gln Leu Ala Ala Ser Ala Lys 
                85                  90                  95      


Arg Tyr Gly Phe Asp Ala Val Ser Ala Val Thr Pro Phe Tyr Tyr Pro 
            100                 105                 110         


Phe Ser Phe Glu Glu His Cys Asp His Tyr Arg Ala Ile Ile Asp Ser 
        115                 120                 125             


Ala Asp Gly Leu Pro Met Val Val Tyr Asn Ile Pro Ala Leu Ser Gly 
    130                 135                 140                 


Val Lys Leu Thr Leu Asp Gln Ile Asn Thr Leu Val Thr Leu Pro Gly 
145                 150                 155                 160 


Val Gly Ala Leu Lys Gln Thr Ser Gly Asp Leu Tyr Gln Met Glu Gln 
                165                 170                 175     


Ile Arg Arg Glu His Pro Asp Leu Val Leu Tyr Asn Gly Tyr Asp Glu 
            180                 185                 190         


Ile Phe Ala Ser Gly Leu Leu Ala Gly Ala Asp Gly Gly Ile Gly Ser 
        195                 200                 205             


Thr Tyr Asn Ile Met Gly Trp Arg Tyr Gln Gly Ile Val Lys Ala Leu 
    210                 215                 220                 


Lys Glu Gly Asp Ile Gln Thr Ala Gln Lys Leu Gln Thr Glu Cys Asn 
225                 230                 235                 240 


Lys Val Ile Asp Leu Leu Ile Lys Thr Gly Val Phe Arg Gly Leu Lys 
                245                 250                 255     


Thr Val Leu His Tyr Met Asp Val Val Ser Val Pro Leu Cys Arg Lys 
            260                 265                 270         


Pro Phe Gly Pro Val Asp Glu Lys Tyr Leu Pro Glu Leu Lys Ala Leu 
        275                 280                 285             


Ala Gln Gln Leu Met Gln Glu Arg Gly 
    290                 295         


<210>  26
<211>  2863
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<222>  (1)..(2863)
<223>  pMUT1 backbone

<400>  26
tcacaagaga cactcaatgg caaaggaaga ccgtgccctg ttatccaggc ttatggcaga       60

ttagcttccc ggagagaaaa ctgtcgaaaa ctgacggtat gaacaccgta agctcccaaa      120

gtgatcacca ttcgctttca tgcatagcta tgcagcgagc tgaaacgatc ctgacgcatc      180

cttcctgttt ttccggggta aaacatctct ttttgcggtg tctcgcgtca gaatcgcgtt      240

cagcgcgttt cagtggtgcg tacaattaag ggattatggt aaatatatga gctatgcgat      300

aactttaact gtgaagcgat gaacccatta caggcaaagc caattactcc tgacagtggt      360

ttagccagaa gcagggctac caagaccaat gcaataagta atatatcgtt ttgctatcgt      420

gccatccgtc gcgctcagtt ccattgtgct tttttaagct gtcgtttttc ttacggtata      480

taccggtttt ttatggcgtg gtttcttaac ttgttcagct actgatggac ccatgtatct      540

aggtagtcaa ctagctttgt tagatcataa aatattgcga ccaccatatc ggcgatcact      600

cttcgatgtt ggtttcttgt ccaagagatt agctttttca agatcattga tagctctctg      660

aacagtccgt acagaaaccc ccatacgtat ggctagactt tccattgacg gatgcggcca      720

ctcttgcaaa ctccaccagt gaacgatcag gttaagtagt gtgttaaagg ccactgaagt      780

tagctttttc tcgttttgta taaaaaacaa tacggtaggc actgctgtcc agccaagaga      840

caaaccgcca gctttccatt tattcttaac ggagtaagtc attgattttc ctaagcccca      900

aaatatttaa agtatatatt atatgtatat tcatatgaat agggtgacac tggcgccatt      960

attgtgcaac caaaaaagac tactctgaaa acgaggaaaa gattttttcc tgcctgaatt     1020

agatacggag ttagcgatat gaaaaccgaa caacgtcatg atcttgttaa agatattgag     1080

gtttttggcg tatccttgtc tctgttgatt tccagagcga atgagaagtc tgttacaatg     1140

ccatctggtc taagtcggga gcagagaaga gcatgggcag cggagcaggc gcgcaaaatc     1200

cacaattgaa tattgtctca ttctctgaga ccttcaacct ttattacaca tccagatatt     1260

ctgcaaaaac actcgataaa atcgatgatt tcattgagca ttttgaaaaa tacaatctct     1320

ttggcgatcc tttaaaagga tatccagctt ggactggcaa agtatcgcca tcgtggaaag     1380

tgcctgatca ttacgaaaac aaagaagcta ttgagaagta tgctagagct aacaaattat     1440

ggcatgctca tttaggcgat ccggttttta aagatacgtt tcatgggaaa tacaaggttt     1500

ctgactgggt tattcatttc cagcggctga caccgaacca tataaagctt ttagagcttg     1560

gataccatga cccaatgaag ctacctcaaa actttgaatg atcgagcggc aggctaaatg     1620

aaatcttgag attcattcag tctcgtcgta atctcactat tgtaaaaacg aaaaaaccac     1680

cctggcaggt ggtttttcga aggttagtta atcctggcag attctctaac cgtggtaaca     1740

gtcttgtgcg agacatgtca ccaaatactg tcctttcagt gtagcctcag ttaggccgcc     1800

acttcaagaa ctctcgttac atctctcgca catcctgctt accagtggcc gttgccagtg     1860

gcgttaagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc     1920

ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg     1980

aaccgagata ccaacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg     2040

cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag     2100

ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc     2160

gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgcctcc cgcgcgccct     2220

tcttctgggt ctttgtcttt tgctcacatg ttctttccgg ttttatcccc cgattctgtg     2280

gataaccgta ttaccgcctt tgagtgagct gacaccgctc gccgcagtcg aacgaccgag     2340

cgtagcgagt cagtgagcga ggaagcggaa gagcgcctta tgtgacattt tctccttacg     2400

ctcctctatg ccgttctgca tcctgtccgg atgcgttata tcccggtaag attttccgct     2460

tcaaagcgtg tctgtatgct gttctggagt tcttctgcga gttcgtgcag tttctcacac     2520

atggcggcct gttcgtcggc attgagtgcg tccagttttt cgagcagcgt caggctctga     2580

ctttttatga atcccgccat gttgagtacg gcttgctgct gcttattcat cttttcgttt     2640

tctccgttct gtctgtcatc tgcgttgtgt gattatatcg cgtaccactt ttcgactgtt     2700

ttgctgccgc tattctgccg cttggctttt tgacgggcat ttctgtcaga caacactgtc     2760

actgccaaaa aactgccgtg cctttgtcgg taattcgagc ttgctgacag gacaggatgt     2820

gcaattgtta taccgcgcat acatgcacgc tattacaatt gcc                       2863


<210>  27
<211>  1042
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (129)..(923)
<223>  KanR

<400>  27
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt       60

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa      120

ggaagagt atg att gaa cag gat ggc ctg cat gcg ggt agc ccg gca gcg       170
         Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala          
         1               5                   10                           

tgg gtg gaa cgt ctg ttt ggc tat gat tgg gcg cag cag acc att ggc        218
Trp Val Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly           
15                  20                  25                  30            

tgc tct gat gcg gcg gtg ttt cgt ctg agc gcg cag ggt cgt ccg gtg        266
Cys Ser Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val           
                35                  40                  45                

ctg ttt gtg aaa acc gat ctg agc ggt gcg ctg aac gag ctg cag gat        314
Leu Phe Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp           
            50                  55                  60                    

gaa gcg gcg cgt ctg agc tgg ctg gcc acc acc ggt gtt ccg tgt gcg        362
Glu Ala Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala           
        65                  70                  75                        

gcg gtg ctg gat gtg gtg acc gaa gcg ggc cgt gat tgg ctg ctg ctg        410
Ala Val Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu           
    80                  85                  90                            

ggc gaa gtg ccg ggt cag gat ctg ctg tct agc cat ctg gcg ccg gca        458
Gly Glu Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala           
95                  100                 105                 110           

gaa aaa gtg agc att atg gcg gat gcc atg cgt cgt ctg cat acc ctg        506
Glu Lys Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu           
                115                 120                 125               

gac ccg gcg acc tgt ccg ttt gat cat cag gcg aaa cat cgt att gaa        554
Asp Pro Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu           
            130                 135                 140                   

cgt gcg cgt acc cgt atg gaa gcg ggc ctg gtg gat cag gat gat ctg        602
Arg Ala Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu           
        145                 150                 155                       

gat gaa gaa cat cag ggc ctg gca ccg gca gag ctg ttt gcg cgt ctg        650
Asp Glu Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu           
    160                 165                 170                           

aaa gcg agc atg ccg gat ggc gaa gat ctg gtg gtg acc cat ggt gat        698
Lys Ala Ser Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp           
175                 180                 185                 190           

gcg tgc ctg ccg aac att atg gtg gaa aat ggc cgt ttt agc ggc ttt        746
Ala Cys Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe           
                195                 200                 205               

att gat tgc ggc cgt ctg ggc gtg gcg gat cgt tat cag gat att gcg        794
Ile Asp Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala           
            210                 215                 220                   

ctg gcc acc cgt gat att gcg gaa gaa ctg ggc ggc gaa tgg gcg gat        842
Leu Ala Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp           
        225                 230                 235                       

cgt ttt ctg gtg ctg tat ggc att gcg gca ccg gat agc cag cgt att        890
Arg Phe Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile           
    240                 245                 250                           

gcg ttt tat cgt ctg ctg gat gaa ttt ttc taa taactgtcag accaagttta      943
Ala Phe Tyr Arg Leu Leu Asp Glu Phe Phe                                   
255                 260                                                   

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa     1003

gatccttttt gataatctca tgaccaaaat cccttaacg                            1042


<210>  28
<211>  264
<212>  PRT
<213>  synthetic

<400>  28

Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 
1               5                   10                  15      


Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 
            20                  25                  30          


Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 
        35                  40                  45              


Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 
65                  70                  75                  80  


Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 
                85                  90                  95      


Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 
            100                 105                 110         


Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 
        115                 120                 125             


Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 
    130                 135                 140                 


Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 
145                 150                 155                 160 


Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 
                165                 170                 175     


Ser Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 
            180                 185                 190         


Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 
        195                 200                 205             


Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 
    210                 215                 220                 


Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 
225                 230                 235                 240 


Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 
                245                 250                 255     


Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 


<210>  29
<211>  375
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (1)..(375)
<223>  strR

<400>  29
atg gca aca gtt aac cag ctg gta cgc aaa cca cgt gct cgc aaa gtt         48
Met Ala Thr Val Asn Gln Leu Val Arg Lys Pro Arg Ala Arg Lys Val           
1               5                   10                  15                

gcg aaa agc aac gtg cct gcg ctg gaa gca tgc ccg caa aaa cgt ggc         96
Ala Lys Ser Asn Val Pro Ala Leu Glu Ala Cys Pro Gln Lys Arg Gly           
            20                  25                  30                    

gta tgt act cgt gta tat act acc act cct aga aaa ccg aac tcc gcg        144
Val Cys Thr Arg Val Tyr Thr Thr Thr Pro Arg Lys Pro Asn Ser Ala           
        35                  40                  45                        

ctg cgt aaa gta tgc cgt gtt cgt ctg act aac ggt ttc gaa gtg act        192
Leu Arg Lys Val Cys Arg Val Arg Leu Thr Asn Gly Phe Glu Val Thr           
    50                  55                  60                            

tcc tac atc ggt ggt gaa ggt cac aac ctg cag gag cac tcc gtg atc        240
Ser Tyr Ile Gly Gly Glu Gly His Asn Leu Gln Glu His Ser Val Ile           
65                  70                  75                  80            

ctg atc cgt ggt ggt cgt gtt aaa gac ctc ccg ggt gtt cgt tac cac        288
Leu Ile Arg Gly Gly Arg Val Lys Asp Leu Pro Gly Val Arg Tyr His           
                85                  90                  95                

acc gta cgt ggt gcg ctt gac tgc tcc ggc gtt aaa gac cgt aag cag        336
Thr Val Arg Gly Ala Leu Asp Cys Ser Gly Val Lys Asp Arg Lys Gln           
            100                 105                 110                   

gct cgt tcc aag tat ggc gtg aag cgt cct aag gct taa                    375
Ala Arg Ser Lys Tyr Gly Val Lys Arg Pro Lys Ala                           
        115                 120                                           


<210>  30
<211>  124
<212>  PRT
<213>  synthetic

<400>  30

Met Ala Thr Val Asn Gln Leu Val Arg Lys Pro Arg Ala Arg Lys Val 
1               5                   10                  15      


Ala Lys Ser Asn Val Pro Ala Leu Glu Ala Cys Pro Gln Lys Arg Gly 
            20                  25                  30          


Val Cys Thr Arg Val Tyr Thr Thr Thr Pro Arg Lys Pro Asn Ser Ala 
        35                  40                  45              


Leu Arg Lys Val Cys Arg Val Arg Leu Thr Asn Gly Phe Glu Val Thr 
    50                  55                  60                  


Ser Tyr Ile Gly Gly Glu Gly His Asn Leu Gln Glu His Ser Val Ile 
65                  70                  75                  80  


Leu Ile Arg Gly Gly Arg Val Lys Asp Leu Pro Gly Val Arg Tyr His 
                85                  90                  95      


Thr Val Arg Gly Ala Leu Asp Cys Ser Gly Val Lys Asp Arg Lys Gln 
            100                 105                 110         


Ala Arg Ser Lys Tyr Gly Val Lys Arg Pro Lys Ala 
        115                 120                 


<210>  31
<211>  798
<212>  DNA
<213>  syntehtic


<220>
<221>  CDS
<222>  (82)..(798)
<223>  gene encoding GFP

<400>  31
tcttcacctc gagtttacac ctagctcagt cctaggtatt atgctagcta ctagaggaat       60

tcattaaaga ggagaaaggt a atg agc aaa gga gaa gaa ctt ttc act gga        111
                        Met Ser Lys Gly Glu Glu Leu Phe Thr Gly           
                        1               5                   10            

gtt gtc cca att ctt gtt gaa tta gat ggt gat gtt aat ggg cac aaa        159
Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys           
                15                  20                  25                

ttt tct gtc agt gga gag ggt gaa ggt gat gct aca tac gga aaa ctc        207
Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu           
            30                  35                  40                    

acc ctt aaa ttt att tgc act act gga aaa cta cct gtt cca tgg cca        255
Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro           
        45                  50                  55                        

aca ctt gtc act act ctg acc tat ggt gtt caa tgc ttt tcc cgt tat        303
Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr           
    60                  65                  70                            

ccg gat cac atg aaa cgg cat gac ttt ttc aag agt gcc atg ccc gaa        351
Pro Asp His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu           
75                  80                  85                  90            

ggt tat gta cag gaa cgc act ata tct ttc aaa gat gac ggg aac tac        399
Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr           
                95                  100                 105               

aag acg cgt gct gaa gtc aag ttt gaa ggt gat acc ctt gtt aat cgt        447
Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg           
            110                 115                 120                   

atc gag tta aag ggt att gat ttt aaa gaa gat gga aac att ctc gga        495
Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly           
        125                 130                 135                       

cac aaa cta gag tac aac tat aac tca cac aat gta tac atc acg gca        543
His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala           
    140                 145                 150                           

gac aaa caa aag aat gga atc aaa gct aac ttc aaa att cgc cac aac        591
Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn           
155                 160                 165                 170           

att gaa gat ggt tcc gtt caa cta gca gac cat tat caa caa aat act        639
Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr           
                175                 180                 185               

cca att ggc gat ggc cct gtc ctt tta cca gac aac cat tac ctg tcg        687
Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser           
            190                 195                 200                   

aca caa tct gcc ctt tcg aaa gat ccc aac gaa aag cgt gac cac atg        735
Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met           
        205                 210                 215                       

gtc ctt ctt gag ttt gta act gct gct ggg att aca cat ggc atg gat        783
Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp           
    220                 225                 230                           

gag ctc tac aaa tga                                                    798
Glu Leu Tyr Lys                                                           
235                                                                       


<210>  32
<211>  238
<212>  PRT
<213>  syntehtic

<400>  32

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  33
<211>  1749
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (1)..(1749)
<223>  malR-melD fusion

<400>  33
atg aaa ata aaa aca ggt gca cgc atc ctc gca tta tcc gca tta acg         48
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr           
1               5                   10                  15                

acg atg atg ttt tcc gcc tcg gct ctc gcc atg act ttc acc aac aat         96
Thr Met Met Phe Ser Ala Ser Ala Leu Ala Met Thr Phe Thr Asn Asn           
            20                  25                  30                    

gac tgg tgg cgc gac gcc gtc atc tac cag att tac ccc cgc tca ttc        144
Asp Trp Trp Arg Asp Ala Val Ile Tyr Gln Ile Tyr Pro Arg Ser Phe           
        35                  40                  45                        

agc gat gcc aat gga gac ggc aac ggt gat ctc caa ggc gtg atc gat        192
Ser Asp Ala Asn Gly Asp Gly Asn Gly Asp Leu Gln Gly Val Ile Asp           
    50                  55                  60                            

cgt ctc gac tat ctg cag gcg ctc ggg gtg gac gcg ctc tgg ctt tct        240
Arg Leu Asp Tyr Leu Gln Ala Leu Gly Val Asp Ala Leu Trp Leu Ser           
65                  70                  75                  80            

cca ttc tat cca tcg ccg ctg gcg gat gga ggt tat gat gtt gcc gac        288
Pro Phe Tyr Pro Ser Pro Leu Ala Asp Gly Gly Tyr Asp Val Ala Asp           
                85                  90                  95                

tat tgc gat gtg gat ccc cgc ctt ggc aca ctc gat cag ttc gac gaa        336
Tyr Cys Asp Val Asp Pro Arg Leu Gly Thr Leu Asp Gln Phe Asp Glu           
            100                 105                 110                   

tta gtg gcc aaa gcg cac gaa cgc ggt atc ggc atc atc gtg gac atc        384
Leu Val Ala Lys Ala His Glu Arg Gly Ile Gly Ile Ile Val Asp Ile           
        115                 120                 125                       

gtg ccg aac cac acg tcc gat cag cac cgt tgg ttc caa gag gcc ctg        432
Val Pro Asn His Thr Ser Asp Gln His Arg Trp Phe Gln Glu Ala Leu           
    130                 135                 140                           

gct caa ggt ccg gaa tcg gaa acg gca caa cgg tat gtg ttc cgg cag        480
Ala Gln Gly Pro Glu Ser Glu Thr Ala Gln Arg Tyr Val Phe Arg Gln           
145                 150                 155                 160           

ggc aag ggg gag cac ggc gaa ttg ccg cct acc aac tgg ctg agt aac        528
Gly Lys Gly Glu His Gly Glu Leu Pro Pro Thr Asn Trp Leu Ser Asn           
                165                 170                 175               

ttc ggc ggt tcc gca tgg gag tcg tgt gga gac ggc tgg tac tac ctg        576
Phe Gly Gly Ser Ala Trp Glu Ser Cys Gly Asp Gly Trp Tyr Tyr Leu           
            180                 185                 190                   

cat ctg ttc gcc aag gag cag ccg gac ctc aat tgg gac aat ccc gag        624
His Leu Phe Ala Lys Glu Gln Pro Asp Leu Asn Trp Asp Asn Pro Glu           
        195                 200                 205                       

gtg cgg cat gag ttc ctg cgt gta ctc aca ttc tgg tgc gat cgc ggc        672
Val Arg His Glu Phe Leu Arg Val Leu Thr Phe Trp Cys Asp Arg Gly           
    210                 215                 220                           

gtg gac ggt ttc cgc atc gat gtc tcg cac ggt ctg gcc aaa gac ctg        720
Val Asp Gly Phe Arg Ile Asp Val Ser His Gly Leu Ala Lys Asp Leu           
225                 230                 235                 240           

cgt gag ccg ctg cgc gac cgt atc gac ccg aca ctg atg tct cca cag        768
Arg Glu Pro Leu Arg Asp Arg Ile Asp Pro Thr Leu Met Ser Pro Gln           
                245                 250                 255               

gct acc gat ggt tcc gat ccg ctc tgg gac cgc gac gcc gtg cat gat        816
Ala Thr Asp Gly Ser Asp Pro Leu Trp Asp Arg Asp Ala Val His Asp           
            260                 265                 270                   

atc tac cgt gaa tgg cgc gac ctg ttc aat cag tac atg cca gcc aag        864
Ile Tyr Arg Glu Trp Arg Asp Leu Phe Asn Gln Tyr Met Pro Ala Lys           
        275                 280                 285                       

tat gcg gtc ggc gaa tcg tgg tcg cca ttc acc acc cgt att ttc caa        912
Tyr Ala Val Gly Glu Ser Trp Ser Pro Phe Thr Thr Arg Ile Phe Gln           
    290                 295                 300                           

tac gcc aag cct gat gaa ctt ggt gcc gta ttt gac ttc tcc atg tca        960
Tyr Ala Lys Pro Asp Glu Leu Gly Ala Val Phe Asp Phe Ser Met Ser           
305                 310                 315                 320           

aag gcc gcc tgg aat cgc gaa gaa tac cgc acc acg att gag cgc acg       1008
Lys Ala Ala Trp Asn Arg Glu Glu Tyr Arg Thr Thr Ile Glu Arg Thr           
                325                 330                 335               

cat cgc tat gct ctc gct gcc gaa acc gcc ccc acc tgg gtg ctc ggc       1056
His Arg Tyr Ala Leu Ala Ala Glu Thr Ala Pro Thr Trp Val Leu Gly           
            340                 345                 350                   

aac cac gat gtg cca cgt atc gcc tcg cgt ctc gga ctg ccg agc ggt       1104
Asn His Asp Val Pro Arg Ile Ala Ser Arg Leu Gly Leu Pro Ser Gly           
        355                 360                 365                       

gca aac atc gag cag tgg gtg acg tcc aac ggc acg aat ccg ccg att       1152
Ala Asn Ile Glu Gln Trp Val Thr Ser Asn Gly Thr Asn Pro Pro Ile           
    370                 375                 380                           

gac ccc gcg ctc gcc gct cgt cgt gcc cgt gca gca gcg ctg gtg atg       1200
Asp Pro Ala Leu Ala Ala Arg Arg Ala Arg Ala Ala Ala Leu Val Met           
385                 390                 395                 400           

ctc ggc ctg cca ggt acc gcc ttt gtg tat cag ggt gaa gag ctt ggt       1248
Leu Gly Leu Pro Gly Thr Ala Phe Val Tyr Gln Gly Glu Glu Leu Gly           
                405                 410                 415               

ttg cct gag gac ttt gat ttg acc gaa gat gaa att cag gat ccc aat       1296
Leu Pro Glu Asp Phe Asp Leu Thr Glu Asp Glu Ile Gln Asp Pro Asn           
            420                 425                 430                   

tgg gaa cgt tcc ggt cat tat ttc aag ggg cgc gac ggt tgc cgc gta       1344
Trp Glu Arg Ser Gly His Tyr Phe Lys Gly Arg Asp Gly Cys Arg Val           
        435                 440                 445                       

ccg ctg ccg tgg cag tca gac ggc ccg gcg ttc ggc ttc aat gcc acc       1392
Pro Leu Pro Trp Gln Ser Asp Gly Pro Ala Phe Gly Phe Asn Ala Thr           
    450                 455                 460                           

ggt gct ttg tgg ctg ccc cag ccg gca tgg ttt gcg cag tat gcc gct       1440
Gly Ala Leu Trp Leu Pro Gln Pro Ala Trp Phe Ala Gln Tyr Ala Ala           
465                 470                 475                 480           

aat cgt cag att ggt gac ggg gct tcc gtc ctg cac ctg tat cgt gct       1488
Asn Arg Gln Ile Gly Asp Gly Ala Ser Val Leu His Leu Tyr Arg Ala           
                485                 490                 495               

gcc atc gca ttg cgc aaa cag tgg gtg gac aac ggc acg gac ttc cag       1536
Ala Ile Ala Leu Arg Lys Gln Trp Val Asp Asn Gly Thr Asp Phe Gln           
            500                 505                 510                   

ttc tcg tgg ctt acc aac gaa gag tgt ccg gcg ccg ctg ctt ggt tgg       1584
Phe Ser Trp Leu Thr Asn Glu Glu Cys Pro Ala Pro Leu Leu Gly Trp           
        515                 520                 525                       

cgc ttg ccg tcc ggc atg gtt gtg atg gcg aac ttc tct gac agt caa       1632
Arg Leu Pro Ser Gly Met Val Val Met Ala Asn Phe Ser Asp Ser Gln           
    530                 535                 540                           

cca gtc gcc ttg ccg cag ccg atg acc gtg cta ctt gtg tct gat gcg       1680
Pro Val Ala Leu Pro Gln Pro Met Thr Val Leu Leu Val Ser Asp Ala           
545                 550                 555                 560           

act gtg cag gcg aac act cag gtc gag agc gtt cct cca gct gct acc       1728
Thr Val Gln Ala Asn Thr Gln Val Glu Ser Val Pro Pro Ala Ala Thr           
                565                 570                 575               

gtc tgg gcc ttg cca gca taa                                           1749
Val Trp Ala Leu Pro Ala                                                   
            580                                                           


<210>  34
<211>  582
<212>  PRT
<213>  synthetic

<400>  34

Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala Met Thr Phe Thr Asn Asn 
            20                  25                  30          


Asp Trp Trp Arg Asp Ala Val Ile Tyr Gln Ile Tyr Pro Arg Ser Phe 
        35                  40                  45              


Ser Asp Ala Asn Gly Asp Gly Asn Gly Asp Leu Gln Gly Val Ile Asp 
    50                  55                  60                  


Arg Leu Asp Tyr Leu Gln Ala Leu Gly Val Asp Ala Leu Trp Leu Ser 
65                  70                  75                  80  


Pro Phe Tyr Pro Ser Pro Leu Ala Asp Gly Gly Tyr Asp Val Ala Asp 
                85                  90                  95      


Tyr Cys Asp Val Asp Pro Arg Leu Gly Thr Leu Asp Gln Phe Asp Glu 
            100                 105                 110         


Leu Val Ala Lys Ala His Glu Arg Gly Ile Gly Ile Ile Val Asp Ile 
        115                 120                 125             


Val Pro Asn His Thr Ser Asp Gln His Arg Trp Phe Gln Glu Ala Leu 
    130                 135                 140                 


Ala Gln Gly Pro Glu Ser Glu Thr Ala Gln Arg Tyr Val Phe Arg Gln 
145                 150                 155                 160 


Gly Lys Gly Glu His Gly Glu Leu Pro Pro Thr Asn Trp Leu Ser Asn 
                165                 170                 175     


Phe Gly Gly Ser Ala Trp Glu Ser Cys Gly Asp Gly Trp Tyr Tyr Leu 
            180                 185                 190         


His Leu Phe Ala Lys Glu Gln Pro Asp Leu Asn Trp Asp Asn Pro Glu 
        195                 200                 205             


Val Arg His Glu Phe Leu Arg Val Leu Thr Phe Trp Cys Asp Arg Gly 
    210                 215                 220                 


Val Asp Gly Phe Arg Ile Asp Val Ser His Gly Leu Ala Lys Asp Leu 
225                 230                 235                 240 


Arg Glu Pro Leu Arg Asp Arg Ile Asp Pro Thr Leu Met Ser Pro Gln 
                245                 250                 255     


Ala Thr Asp Gly Ser Asp Pro Leu Trp Asp Arg Asp Ala Val His Asp 
            260                 265                 270         


Ile Tyr Arg Glu Trp Arg Asp Leu Phe Asn Gln Tyr Met Pro Ala Lys 
        275                 280                 285             


Tyr Ala Val Gly Glu Ser Trp Ser Pro Phe Thr Thr Arg Ile Phe Gln 
    290                 295                 300                 


Tyr Ala Lys Pro Asp Glu Leu Gly Ala Val Phe Asp Phe Ser Met Ser 
305                 310                 315                 320 


Lys Ala Ala Trp Asn Arg Glu Glu Tyr Arg Thr Thr Ile Glu Arg Thr 
                325                 330                 335     


His Arg Tyr Ala Leu Ala Ala Glu Thr Ala Pro Thr Trp Val Leu Gly 
            340                 345                 350         


Asn His Asp Val Pro Arg Ile Ala Ser Arg Leu Gly Leu Pro Ser Gly 
        355                 360                 365             


Ala Asn Ile Glu Gln Trp Val Thr Ser Asn Gly Thr Asn Pro Pro Ile 
    370                 375                 380                 


Asp Pro Ala Leu Ala Ala Arg Arg Ala Arg Ala Ala Ala Leu Val Met 
385                 390                 395                 400 


Leu Gly Leu Pro Gly Thr Ala Phe Val Tyr Gln Gly Glu Glu Leu Gly 
                405                 410                 415     


Leu Pro Glu Asp Phe Asp Leu Thr Glu Asp Glu Ile Gln Asp Pro Asn 
            420                 425                 430         


Trp Glu Arg Ser Gly His Tyr Phe Lys Gly Arg Asp Gly Cys Arg Val 
        435                 440                 445             


Pro Leu Pro Trp Gln Ser Asp Gly Pro Ala Phe Gly Phe Asn Ala Thr 
    450                 455                 460                 


Gly Ala Leu Trp Leu Pro Gln Pro Ala Trp Phe Ala Gln Tyr Ala Ala 
465                 470                 475                 480 


Asn Arg Gln Ile Gly Asp Gly Ala Ser Val Leu His Leu Tyr Arg Ala 
                485                 490                 495     


Ala Ile Ala Leu Arg Lys Gln Trp Val Asp Asn Gly Thr Asp Phe Gln 
            500                 505                 510         


Phe Ser Trp Leu Thr Asn Glu Glu Cys Pro Ala Pro Leu Leu Gly Trp 
        515                 520                 525             


Arg Leu Pro Ser Gly Met Val Val Met Ala Asn Phe Ser Asp Ser Gln 
    530                 535                 540                 


Pro Val Ala Leu Pro Gln Pro Met Thr Val Leu Leu Val Ser Asp Ala 
545                 550                 555                 560 


Thr Val Gln Ala Asn Thr Gln Val Glu Ser Val Pro Pro Ala Ala Thr 
                565                 570                 575     


Val Trp Ala Leu Pro Ala 
            580         


<210>  35
<211>  1788
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (1)..(1788)
<223>  torA-melD fusion

<400>  35
atg aac aat aac gat ctc ttt cag gca tca cgt cgg cgt ttt ctg gca         48
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala           
1               5                   10                  15                

caa ctc ggc ggc tta acc gtc gcc ggg atg ctg ggg ccg tca ttg tta         96
Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu           
            20                  25                  30                    

acg ccg cga cgt gcg act gcg atg act ttc acc aac aat gac tgg tgg        144
Thr Pro Arg Arg Ala Thr Ala Met Thr Phe Thr Asn Asn Asp Trp Trp           
        35                  40                  45                        

cgc gac gcc gtc atc tac cag att tac ccc cgc tca ttc agc gat gcc        192
Arg Asp Ala Val Ile Tyr Gln Ile Tyr Pro Arg Ser Phe Ser Asp Ala           
    50                  55                  60                            

aat gga gac ggc aac ggt gat ctc caa ggc gtg atc gat cgt ctc gac        240
Asn Gly Asp Gly Asn Gly Asp Leu Gln Gly Val Ile Asp Arg Leu Asp           
65                  70                  75                  80            

tat ctg cag gcg ctc ggg gtg gac gcg ctc tgg ctt tct cca ttc tat        288
Tyr Leu Gln Ala Leu Gly Val Asp Ala Leu Trp Leu Ser Pro Phe Tyr           
                85                  90                  95                

cca tcg ccg ctg gcg gat gga ggt tat gat gtt gcc gac tat tgc gat        336
Pro Ser Pro Leu Ala Asp Gly Gly Tyr Asp Val Ala Asp Tyr Cys Asp           
            100                 105                 110                   

gtg gat ccc cgc ctt ggc aca ctc gat cag ttc gac gaa tta gtg gcc        384
Val Asp Pro Arg Leu Gly Thr Leu Asp Gln Phe Asp Glu Leu Val Ala           
        115                 120                 125                       

aaa gcg cac gaa cgc ggt atc ggc atc atc gtg gac atc gtg ccg aac        432
Lys Ala His Glu Arg Gly Ile Gly Ile Ile Val Asp Ile Val Pro Asn           
    130                 135                 140                           

cac acg tcc gat cag cac cgt tgg ttc caa gag gcc ctg gct caa ggt        480
His Thr Ser Asp Gln His Arg Trp Phe Gln Glu Ala Leu Ala Gln Gly           
145                 150                 155                 160           

ccg gaa tcg gaa acg gca caa cgg tat gtg ttc cgg cag ggc aag ggg        528
Pro Glu Ser Glu Thr Ala Gln Arg Tyr Val Phe Arg Gln Gly Lys Gly           
                165                 170                 175               

gag cac ggc gaa ttg ccg cct acc aac tgg ctg agt aac ttc ggc ggt        576
Glu His Gly Glu Leu Pro Pro Thr Asn Trp Leu Ser Asn Phe Gly Gly           
            180                 185                 190                   

tcc gca tgg gag tcg tgt gga gac ggc tgg tac tac ctg cat ctg ttc        624
Ser Ala Trp Glu Ser Cys Gly Asp Gly Trp Tyr Tyr Leu His Leu Phe           
        195                 200                 205                       

gcc aag gag cag ccg gac ctc aat tgg gac aat ccc gag gtg cgg cat        672
Ala Lys Glu Gln Pro Asp Leu Asn Trp Asp Asn Pro Glu Val Arg His           
    210                 215                 220                           

gag ttc ctg cgt gta ctc aca ttc tgg tgc gat cgc ggc gtg gac ggt        720
Glu Phe Leu Arg Val Leu Thr Phe Trp Cys Asp Arg Gly Val Asp Gly           
225                 230                 235                 240           

ttc cgc atc gat gtc tcg cac ggt ctg gcc aaa gac ctg cgt gag ccg        768
Phe Arg Ile Asp Val Ser His Gly Leu Ala Lys Asp Leu Arg Glu Pro           
                245                 250                 255               

ctg cgc gac cgt atc gac ccg aca ctg atg tct cca cag gct acc gat        816
Leu Arg Asp Arg Ile Asp Pro Thr Leu Met Ser Pro Gln Ala Thr Asp           
            260                 265                 270                   

ggt tcc gat ccg ctc tgg gac cgc gac gcc gtg cat gat atc tac cgt        864
Gly Ser Asp Pro Leu Trp Asp Arg Asp Ala Val His Asp Ile Tyr Arg           
        275                 280                 285                       

gaa tgg cgc gac ctg ttc aat cag tac atg cca gcc aag tat gcg gtc        912
Glu Trp Arg Asp Leu Phe Asn Gln Tyr Met Pro Ala Lys Tyr Ala Val           
    290                 295                 300                           

ggc gaa tcg tgg tcg cca ttc acc acc cgt att ttc caa tac gcc aag        960
Gly Glu Ser Trp Ser Pro Phe Thr Thr Arg Ile Phe Gln Tyr Ala Lys           
305                 310                 315                 320           

cct gat gaa ctt ggt gcc gta ttt gac ttc tcc atg tca aag gcc gcc       1008
Pro Asp Glu Leu Gly Ala Val Phe Asp Phe Ser Met Ser Lys Ala Ala           
                325                 330                 335               

tgg aat cgc gaa gaa tac cgc acc acg att gag cgc acg cat cgc tat       1056
Trp Asn Arg Glu Glu Tyr Arg Thr Thr Ile Glu Arg Thr His Arg Tyr           
            340                 345                 350                   

gct ctc gct gcc gaa acc gcc ccc acc tgg gtg ctc ggc aac cac gat       1104
Ala Leu Ala Ala Glu Thr Ala Pro Thr Trp Val Leu Gly Asn His Asp           
        355                 360                 365                       

gtg cca cgt atc gcc tcg cgt ctc gga ctg ccg agc ggt gca aac atc       1152
Val Pro Arg Ile Ala Ser Arg Leu Gly Leu Pro Ser Gly Ala Asn Ile           
    370                 375                 380                           

gag cag tgg gtg acg tcc aac ggc acg aat ccg ccg att gac ccc gcg       1200
Glu Gln Trp Val Thr Ser Asn Gly Thr Asn Pro Pro Ile Asp Pro Ala           
385                 390                 395                 400           

ctc gcc gct cgt cgt gcc cgt gca gca gcg ctg gtg atg ctc ggc ctg       1248
Leu Ala Ala Arg Arg Ala Arg Ala Ala Ala Leu Val Met Leu Gly Leu           
                405                 410                 415               

cca ggt acc gcc ttt gtg tat cag ggt gaa gag ctt ggt ttg cct gag       1296
Pro Gly Thr Ala Phe Val Tyr Gln Gly Glu Glu Leu Gly Leu Pro Glu           
            420                 425                 430                   

gac ttt gat ttg acc gaa gat gaa att cag gat ccc aat tgg gaa cgt       1344
Asp Phe Asp Leu Thr Glu Asp Glu Ile Gln Asp Pro Asn Trp Glu Arg           
        435                 440                 445                       

tcc ggt cat tat ttc aag ggg cgc gac ggt tgc cgc gta ccg ctg ccg       1392
Ser Gly His Tyr Phe Lys Gly Arg Asp Gly Cys Arg Val Pro Leu Pro           
    450                 455                 460                           

tgg cag tca gac ggc ccg gcg ttc ggc ttc aat gcc acc ggt gct ttg       1440
Trp Gln Ser Asp Gly Pro Ala Phe Gly Phe Asn Ala Thr Gly Ala Leu           
465                 470                 475                 480           

tgg ctg ccc cag ccg gca tgg ttt gcg cag tat gcc gct aat cgt cag       1488
Trp Leu Pro Gln Pro Ala Trp Phe Ala Gln Tyr Ala Ala Asn Arg Gln           
                485                 490                 495               

att ggt gac ggg gct tcc gtc ctg cac ctg tat cgt gct gcc atc gca       1536
Ile Gly Asp Gly Ala Ser Val Leu His Leu Tyr Arg Ala Ala Ile Ala           
            500                 505                 510                   

ttg cgc aaa cag tgg gtg gac aac ggc acg gac ttc cag ttc tcg tgg       1584
Leu Arg Lys Gln Trp Val Asp Asn Gly Thr Asp Phe Gln Phe Ser Trp           
        515                 520                 525                       

ctt acc aac gaa gag tgt ccg gcg ccg ctg ctt ggt tgg cgc ttg ccg       1632
Leu Thr Asn Glu Glu Cys Pro Ala Pro Leu Leu Gly Trp Arg Leu Pro           
    530                 535                 540                           

tcc ggc atg gtt gtg atg gcg aac ttc tct gac agt caa cca gtc gcc       1680
Ser Gly Met Val Val Met Ala Asn Phe Ser Asp Ser Gln Pro Val Ala           
545                 550                 555                 560           

ttg ccg cag ccg atg acc gtg cta ctt gtg tct gat gcg act gtg cag       1728
Leu Pro Gln Pro Met Thr Val Leu Leu Val Ser Asp Ala Thr Val Gln           
                565                 570                 575               

gcg aac act cag gtc gag agc gtt cct cca gct gct acc gtc tgg gcc       1776
Ala Asn Thr Gln Val Glu Ser Val Pro Pro Ala Ala Thr Val Trp Ala           
            580                 585                 590                   

ttg cca gca taa                                                       1788
Leu Pro Ala                                                               
        595                                                               


<210>  36
<211>  595
<212>  PRT
<213>  synthetic

<400>  36

Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Met Thr Phe Thr Asn Asn Asp Trp Trp 
        35                  40                  45              


Arg Asp Ala Val Ile Tyr Gln Ile Tyr Pro Arg Ser Phe Ser Asp Ala 
    50                  55                  60                  


Asn Gly Asp Gly Asn Gly Asp Leu Gln Gly Val Ile Asp Arg Leu Asp 
65                  70                  75                  80  


Tyr Leu Gln Ala Leu Gly Val Asp Ala Leu Trp Leu Ser Pro Phe Tyr 
                85                  90                  95      


Pro Ser Pro Leu Ala Asp Gly Gly Tyr Asp Val Ala Asp Tyr Cys Asp 
            100                 105                 110         


Val Asp Pro Arg Leu Gly Thr Leu Asp Gln Phe Asp Glu Leu Val Ala 
        115                 120                 125             


Lys Ala His Glu Arg Gly Ile Gly Ile Ile Val Asp Ile Val Pro Asn 
    130                 135                 140                 


His Thr Ser Asp Gln His Arg Trp Phe Gln Glu Ala Leu Ala Gln Gly 
145                 150                 155                 160 


Pro Glu Ser Glu Thr Ala Gln Arg Tyr Val Phe Arg Gln Gly Lys Gly 
                165                 170                 175     


Glu His Gly Glu Leu Pro Pro Thr Asn Trp Leu Ser Asn Phe Gly Gly 
            180                 185                 190         


Ser Ala Trp Glu Ser Cys Gly Asp Gly Trp Tyr Tyr Leu His Leu Phe 
        195                 200                 205             


Ala Lys Glu Gln Pro Asp Leu Asn Trp Asp Asn Pro Glu Val Arg His 
    210                 215                 220                 


Glu Phe Leu Arg Val Leu Thr Phe Trp Cys Asp Arg Gly Val Asp Gly 
225                 230                 235                 240 


Phe Arg Ile Asp Val Ser His Gly Leu Ala Lys Asp Leu Arg Glu Pro 
                245                 250                 255     


Leu Arg Asp Arg Ile Asp Pro Thr Leu Met Ser Pro Gln Ala Thr Asp 
            260                 265                 270         


Gly Ser Asp Pro Leu Trp Asp Arg Asp Ala Val His Asp Ile Tyr Arg 
        275                 280                 285             


Glu Trp Arg Asp Leu Phe Asn Gln Tyr Met Pro Ala Lys Tyr Ala Val 
    290                 295                 300                 


Gly Glu Ser Trp Ser Pro Phe Thr Thr Arg Ile Phe Gln Tyr Ala Lys 
305                 310                 315                 320 


Pro Asp Glu Leu Gly Ala Val Phe Asp Phe Ser Met Ser Lys Ala Ala 
                325                 330                 335     


Trp Asn Arg Glu Glu Tyr Arg Thr Thr Ile Glu Arg Thr His Arg Tyr 
            340                 345                 350         


Ala Leu Ala Ala Glu Thr Ala Pro Thr Trp Val Leu Gly Asn His Asp 
        355                 360                 365             


Val Pro Arg Ile Ala Ser Arg Leu Gly Leu Pro Ser Gly Ala Asn Ile 
    370                 375                 380                 


Glu Gln Trp Val Thr Ser Asn Gly Thr Asn Pro Pro Ile Asp Pro Ala 
385                 390                 395                 400 


Leu Ala Ala Arg Arg Ala Arg Ala Ala Ala Leu Val Met Leu Gly Leu 
                405                 410                 415     


Pro Gly Thr Ala Phe Val Tyr Gln Gly Glu Glu Leu Gly Leu Pro Glu 
            420                 425                 430         


Asp Phe Asp Leu Thr Glu Asp Glu Ile Gln Asp Pro Asn Trp Glu Arg 
        435                 440                 445             


Ser Gly His Tyr Phe Lys Gly Arg Asp Gly Cys Arg Val Pro Leu Pro 
    450                 455                 460                 


Trp Gln Ser Asp Gly Pro Ala Phe Gly Phe Asn Ala Thr Gly Ala Leu 
465                 470                 475                 480 


Trp Leu Pro Gln Pro Ala Trp Phe Ala Gln Tyr Ala Ala Asn Arg Gln 
                485                 490                 495     


Ile Gly Asp Gly Ala Ser Val Leu His Leu Tyr Arg Ala Ala Ile Ala 
            500                 505                 510         


Leu Arg Lys Gln Trp Val Asp Asn Gly Thr Asp Phe Gln Phe Ser Trp 
        515                 520                 525             


Leu Thr Asn Glu Glu Cys Pro Ala Pro Leu Leu Gly Trp Arg Leu Pro 
    530                 535                 540                 


Ser Gly Met Val Val Met Ala Asn Phe Ser Asp Ser Gln Pro Val Ala 
545                 550                 555                 560 


Leu Pro Gln Pro Met Thr Val Leu Leu Val Ser Asp Ala Thr Val Gln 
                565                 570                 575     


Ala Asn Thr Gln Val Glu Ser Val Pro Pro Ala Ala Thr Val Trp Ala 
            580                 585                 590         


Leu Pro Ala 
        595 


<210>  37
<211>  1554
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (1)..(1554)
<223>  torA-blon_2336 fusion

<400>  37
atg aac aat aac gat ctc ttt cag gca tca cgt cgg cgt ttt ctg gca         48
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala           
1               5                   10                  15                

caa ctc ggc ggc tta acc gtc gcc ggg atg ctg ggg ccg tca ttg tta         96
Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu           
            20                  25                  30                    

acg ccg cga cgt gcg act gcg atg aac aat cct gca gat gcg ggc atc        144
Thr Pro Arg Arg Ala Thr Ala Met Asn Asn Pro Ala Asp Ala Gly Ile           
        35                  40                  45                        

aac ctg aac tat ctc gcg aat gtg cgc cca tcg tcg cgc cag ctt gcc        192
Asn Leu Asn Tyr Leu Ala Asn Val Arg Pro Ser Ser Arg Gln Leu Ala           
    50                  55                  60                            

tgg cag cgc atg gag atg tac gcc ttc ctg cac ttc ggc atg aac acc        240
Trp Gln Arg Met Glu Met Tyr Ala Phe Leu His Phe Gly Met Asn Thr           
65                  70                  75                  80            

atg acg gac agg gag tgg ggt ctt ggg cat gag gat ccg gca ctg ttc        288
Met Thr Asp Arg Glu Trp Gly Leu Gly His Glu Asp Pro Ala Leu Phe           
                85                  90                  95                

aac ccg cgg aac gtg gac gtg gac cag tgg atg gac gcg ctg gtg gcc        336
Asn Pro Arg Asn Val Asp Val Asp Gln Trp Met Asp Ala Leu Val Ala           
            100                 105                 110                   

ggc ggg atg gcc ggc gtc atc ctg acg tgc aag cac cac gac gga ttc        384
Gly Gly Met Ala Gly Val Ile Leu Thr Cys Lys His His Asp Gly Phe           
        115                 120                 125                       

tgc ctg tgg ccg tcc cga ttg acg cgg cac acc gtc gcc tcg tcg ccg        432
Cys Leu Trp Pro Ser Arg Leu Thr Arg His Thr Val Ala Ser Ser Pro           
    130                 135                 140                           

tgg cgt gaa ggc aag ggc gac ctc gtt cgt gag gtc agc gag tcc gcc        480
Trp Arg Glu Gly Lys Gly Asp Leu Val Arg Glu Val Ser Glu Ser Ala           
145                 150                 155                 160           

agg cgt cac gga ctg aag ttc ggc gtg tac ctg tcc ccg tgg gac cgc        528
Arg Arg His Gly Leu Lys Phe Gly Val Tyr Leu Ser Pro Trp Asp Arg           
                165                 170                 175               

acc gag gaa tcc tac ggc aag ggc aag gcg tac gac gac ttc tac gtc        576
Thr Glu Glu Ser Tyr Gly Lys Gly Lys Ala Tyr Asp Asp Phe Tyr Val           
            180                 185                 190                   

ggc cag ctg acc gag ctg ctc acc cag tac ggg ccg atc ttc tcc gtc        624
Gly Gln Leu Thr Glu Leu Leu Thr Gln Tyr Gly Pro Ile Phe Ser Val           
        195                 200                 205                       

tgg ctt gat ggc gcc aat ggc gag ggc aag aac ggc aag acc cag tac        672
Trp Leu Asp Gly Ala Asn Gly Glu Gly Lys Asn Gly Lys Thr Gln Tyr           
    210                 215                 220                           

tac gac tgg gat cgt tac tac aac gtc atc cgt tcg ctc cag ccc gat        720
Tyr Asp Trp Asp Arg Tyr Tyr Asn Val Ile Arg Ser Leu Gln Pro Asp           
225                 230                 235                 240           

gcg gtg att tcc gtg tgc ggc ccc gac gtg cgc tgg gcc ggg aac gaa        768
Ala Val Ile Ser Val Cys Gly Pro Asp Val Arg Trp Ala Gly Asn Glu           
                245                 250                 255               

gcc ggg cat gtg cgc gac aac gaa tgg agc gtc gtg ccc cgc cgc ctg        816
Ala Gly His Val Arg Asp Asn Glu Trp Ser Val Val Pro Arg Arg Leu           
            260                 265                 270                   

cgt tcg gcg gaa ctg acc atg gag aag tcg cag cag gag gat gac gca        864
Arg Ser Ala Glu Leu Thr Met Glu Lys Ser Gln Gln Glu Asp Asp Ala           
        275                 280                 285                       

tcc ttc gcc acc acg gtc agc tcc cag gac gac gac ctc ggc agc cgt        912
Ser Phe Ala Thr Thr Val Ser Ser Gln Asp Asp Asp Leu Gly Ser Arg           
    290                 295                 300                           

gag gcg gtc gcc gga tac ggg gac aac gtc tgc tgg tac ccg gcc gag        960
Glu Ala Val Ala Gly Tyr Gly Asp Asn Val Cys Trp Tyr Pro Ala Glu           
305                 310                 315                 320           

gtc gac acc tcc atc cgc ccc ggg tgg ttc tac cac cag tcc gag gac       1008
Val Asp Thr Ser Ile Arg Pro Gly Trp Phe Tyr His Gln Ser Glu Asp           
                325                 330                 335               

gac aag gtc atg agc gcc gat cag ctg ttc gac ctc tgg ctt tcc gcg       1056
Asp Lys Val Met Ser Ala Asp Gln Leu Phe Asp Leu Trp Leu Ser Ala           
            340                 345                 350                   

gta ggc ggc aat tca tcg ttg ctg ctc aac att cct ccc tcg ccg gaa       1104
Val Gly Gly Asn Ser Ser Leu Leu Leu Asn Ile Pro Pro Ser Pro Glu           
        355                 360                 365                       

ggt ctg ctc gcc gaa ccg gat gtg cag tcg ctc aag gga ttg ggc cgc       1152
Gly Leu Leu Ala Glu Pro Asp Val Gln Ser Leu Lys Gly Leu Gly Arg           
    370                 375                 380                           

cgc gtc agc gag ttc cgt gaa gcg ctg gcc tcg gtc cgc tgc gaa gcc       1200
Arg Val Ser Glu Phe Arg Glu Ala Leu Ala Ser Val Arg Cys Glu Ala           
385                 390                 395                 400           

agg acc agc agc gca tcc gcc gcc gcg gcg cat ctc gtc gac ggg aat       1248
Arg Thr Ser Ser Ala Ser Ala Ala Ala Ala His Leu Val Asp Gly Asn           
                405                 410                 415               

cgg gac acg ttc tgg cgc ccg gat gcc gac gat gcg gcc ccc gcc atc       1296
Arg Asp Thr Phe Trp Arg Pro Asp Ala Asp Asp Ala Ala Pro Ala Ile           
            420                 425                 430                   

acg ctc acc ctc ccg cag ccc acg acg atc aac gcc atc gtg atc gag       1344
Thr Leu Thr Leu Pro Gln Pro Thr Thr Ile Asn Ala Ile Val Ile Glu           
        435                 440                 445                       

gag gcc ata gag cac ggt cag cgc atc gag cat ctg cgc gtc acg ggt       1392
Glu Ala Ile Glu His Gly Gln Arg Ile Glu His Leu Arg Val Thr Gly           
    450                 455                 460                           

gcg ctg cct gac ggc acc gag cgc gtg ctc ggc cag gcc ggc acg gtg       1440
Ala Leu Pro Asp Gly Thr Glu Arg Val Leu Gly Gln Ala Gly Thr Val           
465                 470                 475                 480           

ggt tac cgg agg ata ctc cgc ttc gac gat gtc gag gtg tcc tcg gtc       1488
Gly Tyr Arg Arg Ile Leu Arg Phe Asp Asp Val Glu Val Ser Ser Val           
                485                 490                 495               

acc ctt cac gtg gac ggt tcg agg ctt gcg ccg atg atc agc cgc gcg       1536
Thr Leu His Val Asp Gly Ser Arg Leu Ala Pro Met Ile Ser Arg Ala           
            500                 505                 510                   

gct gcc gtg cgc atc tga                                               1554
Ala Ala Val Arg Ile                                                       
        515                                                               


<210>  38
<211>  517
<212>  PRT
<213>  synthetic

<400>  38

Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Met Asn Asn Pro Ala Asp Ala Gly Ile 
        35                  40                  45              


Asn Leu Asn Tyr Leu Ala Asn Val Arg Pro Ser Ser Arg Gln Leu Ala 
    50                  55                  60                  


Trp Gln Arg Met Glu Met Tyr Ala Phe Leu His Phe Gly Met Asn Thr 
65                  70                  75                  80  


Met Thr Asp Arg Glu Trp Gly Leu Gly His Glu Asp Pro Ala Leu Phe 
                85                  90                  95      


Asn Pro Arg Asn Val Asp Val Asp Gln Trp Met Asp Ala Leu Val Ala 
            100                 105                 110         


Gly Gly Met Ala Gly Val Ile Leu Thr Cys Lys His His Asp Gly Phe 
        115                 120                 125             


Cys Leu Trp Pro Ser Arg Leu Thr Arg His Thr Val Ala Ser Ser Pro 
    130                 135                 140                 


Trp Arg Glu Gly Lys Gly Asp Leu Val Arg Glu Val Ser Glu Ser Ala 
145                 150                 155                 160 


Arg Arg His Gly Leu Lys Phe Gly Val Tyr Leu Ser Pro Trp Asp Arg 
                165                 170                 175     


Thr Glu Glu Ser Tyr Gly Lys Gly Lys Ala Tyr Asp Asp Phe Tyr Val 
            180                 185                 190         


Gly Gln Leu Thr Glu Leu Leu Thr Gln Tyr Gly Pro Ile Phe Ser Val 
        195                 200                 205             


Trp Leu Asp Gly Ala Asn Gly Glu Gly Lys Asn Gly Lys Thr Gln Tyr 
    210                 215                 220                 


Tyr Asp Trp Asp Arg Tyr Tyr Asn Val Ile Arg Ser Leu Gln Pro Asp 
225                 230                 235                 240 


Ala Val Ile Ser Val Cys Gly Pro Asp Val Arg Trp Ala Gly Asn Glu 
                245                 250                 255     


Ala Gly His Val Arg Asp Asn Glu Trp Ser Val Val Pro Arg Arg Leu 
            260                 265                 270         


Arg Ser Ala Glu Leu Thr Met Glu Lys Ser Gln Gln Glu Asp Asp Ala 
        275                 280                 285             


Ser Phe Ala Thr Thr Val Ser Ser Gln Asp Asp Asp Leu Gly Ser Arg 
    290                 295                 300                 


Glu Ala Val Ala Gly Tyr Gly Asp Asn Val Cys Trp Tyr Pro Ala Glu 
305                 310                 315                 320 


Val Asp Thr Ser Ile Arg Pro Gly Trp Phe Tyr His Gln Ser Glu Asp 
                325                 330                 335     


Asp Lys Val Met Ser Ala Asp Gln Leu Phe Asp Leu Trp Leu Ser Ala 
            340                 345                 350         


Val Gly Gly Asn Ser Ser Leu Leu Leu Asn Ile Pro Pro Ser Pro Glu 
        355                 360                 365             


Gly Leu Leu Ala Glu Pro Asp Val Gln Ser Leu Lys Gly Leu Gly Arg 
    370                 375                 380                 


Arg Val Ser Glu Phe Arg Glu Ala Leu Ala Ser Val Arg Cys Glu Ala 
385                 390                 395                 400 


Arg Thr Ser Ser Ala Ser Ala Ala Ala Ala His Leu Val Asp Gly Asn 
                405                 410                 415     


Arg Asp Thr Phe Trp Arg Pro Asp Ala Asp Asp Ala Ala Pro Ala Ile 
            420                 425                 430         


Thr Leu Thr Leu Pro Gln Pro Thr Thr Ile Asn Ala Ile Val Ile Glu 
        435                 440                 445             


Glu Ala Ile Glu His Gly Gln Arg Ile Glu His Leu Arg Val Thr Gly 
    450                 455                 460                 


Ala Leu Pro Asp Gly Thr Glu Arg Val Leu Gly Gln Ala Gly Thr Val 
465                 470                 475                 480 


Gly Tyr Arg Arg Ile Leu Arg Phe Asp Asp Val Glu Val Ser Ser Val 
                485                 490                 495     


Thr Leu His Val Asp Gly Ser Arg Leu Ala Pro Met Ile Ser Arg Ala 
            500                 505                 510         


Ala Ala Val Arg Ile 
        515         


<210>  39
<211>  869
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (209)..(847)
<223>  camR

<400>  39
ggcgcgccta cctgtgacgg aagatcactt cgcagaataa ataaatcctg gtgtccctgt       60

tgataccggg aagccctggg ccaacttttg gcgaaaatga gacgttgatc ggcacgtaag      120

aggttccaac tttcaccata atgaaataag atcactaccg ggcgtatttt ttgagttgtc      180

gagattttca ggagctaagg aagctaaa atg gag aaa aaa atc act gga tat         232
                               Met Glu Lys Lys Ile Thr Gly Tyr            
                               1               5                          

acc acc gtt gat ata tcc caa tgg cat cgt aaa gaa cat ttt gag gca        280
Thr Thr Val Asp Ile Ser Gln Trp His Arg Lys Glu His Phe Glu Ala           
    10                  15                  20                            

ttt cag tca gtt gct caa tgt acc tat aac cag acc gtt cag ctg gat        328
Phe Gln Ser Val Ala Gln Cys Thr Tyr Asn Gln Thr Val Gln Leu Asp           
25                  30                  35                  40            

att acg gcc ttt tta aag acc gta aag aaa aat aag cac aag ttt tat        376
Ile Thr Ala Phe Leu Lys Thr Val Lys Lys Asn Lys His Lys Phe Tyr           
                45                  50                  55                

ccg gcc ttt att cac att ctt gcc cgc ctg atg aat gct cat ccg gaa        424
Pro Ala Phe Ile His Ile Leu Ala Arg Leu Met Asn Ala His Pro Glu           
            60                  65                  70                    

ttc cgt atg gca atg aaa gac ggt gag ctg gtg ata tgg gat agt gtt        472
Phe Arg Met Ala Met Lys Asp Gly Glu Leu Val Ile Trp Asp Ser Val           
        75                  80                  85                        

cac cct tgt tac acc gtt ttc cat gag caa act gaa acg ttt tca tcg        520
His Pro Cys Tyr Thr Val Phe His Glu Gln Thr Glu Thr Phe Ser Ser           
    90                  95                  100                           

ctc tgg agt gaa tac cac gac gat ttc cgg cag ttt cta cac ata tat        568
Leu Trp Ser Glu Tyr His Asp Asp Phe Arg Gln Phe Leu His Ile Tyr           
105                 110                 115                 120           

tcg caa gat gtg gcg tgt tac ggt gaa aac ctg gcc tat ttc cct aaa        616
Ser Gln Asp Val Ala Cys Tyr Gly Glu Asn Leu Ala Tyr Phe Pro Lys           
                125                 130                 135               

ggg ttt att gag aat atg ttt ttc gtc tca gcc aat ccc tgg gtg agt        664
Gly Phe Ile Glu Asn Met Phe Phe Val Ser Ala Asn Pro Trp Val Ser           
            140                 145                 150                   

ttc acc agt ttt gat tta aac gtg gcc aat atg gac aac ttc ttc gcc        712
Phe Thr Ser Phe Asp Leu Asn Val Ala Asn Met Asp Asn Phe Phe Ala           
        155                 160                 165                       

ccc gtt ttc acc atg ggc aaa tat tat acg caa ggc gac aag gtg ctg        760
Pro Val Phe Thr Met Gly Lys Tyr Tyr Thr Gln Gly Asp Lys Val Leu           
    170                 175                 180                           

atg ccg ctg gcg att cag gtt cat cat gcc gtc tgt gat ggc ttc cat        808
Met Pro Leu Ala Ile Gln Val His His Ala Val Cys Asp Gly Phe His           
185                 190                 195                 200           

gtc ggc aga tgc tta atg aat aca aca gta ctg cga tga gtggcagggc         857
Val Gly Arg Cys Leu Met Asn Thr Thr Val Leu Arg                           
                205                 210                                   

ggggcgtaat tt                                                          869


<210>  40
<211>  212
<212>  PRT
<213>  synthetic

<400>  40

Met Glu Lys Lys Ile Thr Gly Tyr Thr Thr Val Asp Ile Ser Gln Trp 
1               5                   10                  15      


His Arg Lys Glu His Phe Glu Ala Phe Gln Ser Val Ala Gln Cys Thr 
            20                  25                  30          


Tyr Asn Gln Thr Val Gln Leu Asp Ile Thr Ala Phe Leu Lys Thr Val 
        35                  40                  45              


Lys Lys Asn Lys His Lys Phe Tyr Pro Ala Phe Ile His Ile Leu Ala 
    50                  55                  60                  


Arg Leu Met Asn Ala His Pro Glu Phe Arg Met Ala Met Lys Asp Gly 
65                  70                  75                  80  


Glu Leu Val Ile Trp Asp Ser Val His Pro Cys Tyr Thr Val Phe His 
                85                  90                  95      


Glu Gln Thr Glu Thr Phe Ser Ser Leu Trp Ser Glu Tyr His Asp Asp 
            100                 105                 110         


Phe Arg Gln Phe Leu His Ile Tyr Ser Gln Asp Val Ala Cys Tyr Gly 
        115                 120                 125             


Glu Asn Leu Ala Tyr Phe Pro Lys Gly Phe Ile Glu Asn Met Phe Phe 
    130                 135                 140                 


Val Ser Ala Asn Pro Trp Val Ser Phe Thr Ser Phe Asp Leu Asn Val 
145                 150                 155                 160 


Ala Asn Met Asp Asn Phe Phe Ala Pro Val Phe Thr Met Gly Lys Tyr 
                165                 170                 175     


Tyr Thr Gln Gly Asp Lys Val Leu Met Pro Leu Ala Ile Gln Val His 
            180                 185                 190         


His Ala Val Cys Asp Gly Phe His Val Gly Arg Cys Leu Met Asn Thr 
        195                 200                 205             


Thr Val Leu Arg 
    210         


<210>  41
<211>  1141
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (129)..(1100)
<223>  specR

<400>  41
acgttttaat gatatccgga tgaaggcacg aacccagtgg acataagcct cgttcggttc       60

gtaagctgta atgcaagtag cgtaactgcc gtcacgcaac tggtccacaa ccttgaccga      120

acgcagcg atg gta acg gcg cag tgg cgg ttt tca tgg ctt ctt gtt atg       170
         Met Val Thr Ala Gln Trp Arg Phe Ser Trp Leu Leu Val Met          
         1               5                   10                           

aca tgt ttt ttt ggg gta cag tct atg cct cgg gca tcc aag cag caa        218
Thr Cys Phe Phe Gly Val Gln Ser Met Pro Arg Ala Ser Lys Gln Gln           
15                  20                  25                  30            

gcg cgt tac gcc gtg ggt cga tgt ttg atg tta tgg agc agc aac gat        266
Ala Arg Tyr Ala Val Gly Arg Cys Leu Met Leu Trp Ser Ser Asn Asp           
                35                  40                  45                

gtt acg cag cag ggc agt cgc cct aaa aca aag tta aac atc atg agg        314
Val Thr Gln Gln Gly Ser Arg Pro Lys Thr Lys Leu Asn Ile Met Arg           
            50                  55                  60                    

gaa gcg gtg atc gcc gaa gta tcg act caa cta tca gag gta gtt ggc        362
Glu Ala Val Ile Ala Glu Val Ser Thr Gln Leu Ser Glu Val Val Gly           
        65                  70                  75                        

gtc atc gag cgc cat ctc gaa ccg acg ttg ctg gcc gta cat ttg tac        410
Val Ile Glu Arg His Leu Glu Pro Thr Leu Leu Ala Val His Leu Tyr           
    80                  85                  90                            

ggc tcc gca gtg gat ggc ggc ctg aag cca cac agt gat att gat ttg        458
Gly Ser Ala Val Asp Gly Gly Leu Lys Pro His Ser Asp Ile Asp Leu           
95                  100                 105                 110           

ctg gtt acg gtg acc gta agg ctt gat gaa aca acg cgg cga gct ttg        506
Leu Val Thr Val Thr Val Arg Leu Asp Glu Thr Thr Arg Arg Ala Leu           
                115                 120                 125               

atc aac gac ctt ttg gaa act tcg gct tcc cct gga gag agc gag att        554
Ile Asn Asp Leu Leu Glu Thr Ser Ala Ser Pro Gly Glu Ser Glu Ile           
            130                 135                 140                   

ctc cgc gct gta gaa gtc acc att gtt gtg cac gac gac atc att ccg        602
Leu Arg Ala Val Glu Val Thr Ile Val Val His Asp Asp Ile Ile Pro           
        145                 150                 155                       

tgg cgt tat cca gct aag cgc gaa ctg caa ttt gga gaa tgg cag cgc        650
Trp Arg Tyr Pro Ala Lys Arg Glu Leu Gln Phe Gly Glu Trp Gln Arg           
    160                 165                 170                           

aat gac att ctt gca ggt atc ttc gag cca gcc acg tac gac att gat        698
Asn Asp Ile Leu Ala Gly Ile Phe Glu Pro Ala Thr Tyr Asp Ile Asp           
175                 180                 185                 190           

ctg gct atc ttg ctg aca aaa gca aga gaa cat agc gtt gcc ttg gta        746
Leu Ala Ile Leu Leu Thr Lys Ala Arg Glu His Ser Val Ala Leu Val           
                195                 200                 205               

ggt cca gcg gcg gag gaa ctc ttt gat ccg gtt cct gaa cag gat cta        794
Gly Pro Ala Ala Glu Glu Leu Phe Asp Pro Val Pro Glu Gln Asp Leu           
            210                 215                 220                   

ttt gag gcg cta aat gaa acc tta acg cta tgg aac tcg ccg ccc gac        842
Phe Glu Ala Leu Asn Glu Thr Leu Thr Leu Trp Asn Ser Pro Pro Asp           
        225                 230                 235                       

tgg gct ggc gat gag cga aat gta gtg ctt acg ttg tcc cgc att tgg        890
Trp Ala Gly Asp Glu Arg Asn Val Val Leu Thr Leu Ser Arg Ile Trp           
    240                 245                 250                           

tac agc gca gta acc ggc aaa atc gcg ccg aag gat gtc gct gcc gac        938
Tyr Ser Ala Val Thr Gly Lys Ile Ala Pro Lys Asp Val Ala Ala Asp           
255                 260                 265                 270           

tgg gca atg gag cgc ctg ccg gcc cag tat cag ccc gtc ata ctt gaa        986
Trp Ala Met Glu Arg Leu Pro Ala Gln Tyr Gln Pro Val Ile Leu Glu           
                275                 280                 285               

gct aga cag gct tat ctt gga caa gaa gaa gat cgc ttg gcc tcg cgc       1034
Ala Arg Gln Ala Tyr Leu Gly Gln Glu Glu Asp Arg Leu Ala Ser Arg           
            290                 295                 300                   

gca gat cag ttg gaa gaa ttt gtc cac tac gtg aaa ggc gag atc acc       1082
Ala Asp Gln Leu Glu Glu Phe Val His Tyr Val Lys Gly Glu Ile Thr           
        305                 310                 315                       

aag gta gtc ggc aaa taa tgtctaacaa ttcgttcaag ccgacggata              1130
Lys Val Val Gly Lys                                                       
    320                                                                   

ttcgagcacc t                                                          1141


<210>  42
<211>  323
<212>  PRT
<213>  synthetic

<400>  42

Met Val Thr Ala Gln Trp Arg Phe Ser Trp Leu Leu Val Met Thr Cys 
1               5                   10                  15      


Phe Phe Gly Val Gln Ser Met Pro Arg Ala Ser Lys Gln Gln Ala Arg 
            20                  25                  30          


Tyr Ala Val Gly Arg Cys Leu Met Leu Trp Ser Ser Asn Asp Val Thr 
        35                  40                  45              


Gln Gln Gly Ser Arg Pro Lys Thr Lys Leu Asn Ile Met Arg Glu Ala 
    50                  55                  60                  


Val Ile Ala Glu Val Ser Thr Gln Leu Ser Glu Val Val Gly Val Ile 
65                  70                  75                  80  


Glu Arg His Leu Glu Pro Thr Leu Leu Ala Val His Leu Tyr Gly Ser 
                85                  90                  95      


Ala Val Asp Gly Gly Leu Lys Pro His Ser Asp Ile Asp Leu Leu Val 
            100                 105                 110         


Thr Val Thr Val Arg Leu Asp Glu Thr Thr Arg Arg Ala Leu Ile Asn 
        115                 120                 125             


Asp Leu Leu Glu Thr Ser Ala Ser Pro Gly Glu Ser Glu Ile Leu Arg 
    130                 135                 140                 


Ala Val Glu Val Thr Ile Val Val His Asp Asp Ile Ile Pro Trp Arg 
145                 150                 155                 160 


Tyr Pro Ala Lys Arg Glu Leu Gln Phe Gly Glu Trp Gln Arg Asn Asp 
                165                 170                 175     


Ile Leu Ala Gly Ile Phe Glu Pro Ala Thr Tyr Asp Ile Asp Leu Ala 
            180                 185                 190         


Ile Leu Leu Thr Lys Ala Arg Glu His Ser Val Ala Leu Val Gly Pro 
        195                 200                 205             


Ala Ala Glu Glu Leu Phe Asp Pro Val Pro Glu Gln Asp Leu Phe Glu 
    210                 215                 220                 


Ala Leu Asn Glu Thr Leu Thr Leu Trp Asn Ser Pro Pro Asp Trp Ala 
225                 230                 235                 240 


Gly Asp Glu Arg Asn Val Val Leu Thr Leu Ser Arg Ile Trp Tyr Ser 
                245                 250                 255     


Ala Val Thr Gly Lys Ile Ala Pro Lys Asp Val Ala Ala Asp Trp Ala 
            260                 265                 270         


Met Glu Arg Leu Pro Ala Gln Tyr Gln Pro Val Ile Leu Glu Ala Arg 
        275                 280                 285             


Gln Ala Tyr Leu Gly Gln Glu Glu Asp Arg Leu Ala Ser Arg Ala Asp 
    290                 295                 300                 


Gln Leu Glu Glu Phe Val His Tyr Val Lys Gly Glu Ile Thr Lys Val 
305                 310                 315                 320 


Val Gly Lys 
            


<210>  43
<211>  1032
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (1)..(1032)
<223>  TyrOH_rat_trunc

<400>  43
atg aaa agc gca cgt gaa gat aaa gtt ccg tgg ttt ccg cgt aaa gtg         48
Met Lys Ser Ala Arg Glu Asp Lys Val Pro Trp Phe Pro Arg Lys Val           
1               5                   10                  15                

agc gaa ctg gat aaa tgt cat cat ctg gtg acc aaa ttt gat cct gat         96
Ser Glu Leu Asp Lys Cys His His Leu Val Thr Lys Phe Asp Pro Asp           
            20                  25                  30                    

ctg gat ctg gac cat ccg ggt ttt agc gat cag gtt tat cgt cag cgt        144
Leu Asp Leu Asp His Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg           
        35                  40                  45                        

cgt aaa ctg att gca gaa att gcc ttt cag tat aaa cat ggt gaa ccg        192
Arg Lys Leu Ile Ala Glu Ile Ala Phe Gln Tyr Lys His Gly Glu Pro           
    50                  55                  60                            

att ccg cac gtt gaa tat acc gca gaa gaa att gca acc tgg aaa gaa        240
Ile Pro His Val Glu Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu           
65                  70                  75                  80            

gtt tac gtt acc ctg aaa ggt ctg tat gca acc cat gca tgt cgt gaa        288
Val Tyr Val Thr Leu Lys Gly Leu Tyr Ala Thr His Ala Cys Arg Glu           
                85                  90                  95                

cat ctg gaa ggt ttt cag ctg ctg gaa cgt tat tgt ggt tat cgc gaa        336
His Leu Glu Gly Phe Gln Leu Leu Glu Arg Tyr Cys Gly Tyr Arg Glu           
            100                 105                 110                   

gat agc att ccg cag ctg gaa gat gtt agc cgt ttt ctg aaa gaa cgt        384
Asp Ser Ile Pro Gln Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg           
        115                 120                 125                       

acc ggt ttt caa ctg cgt ccg gtt gca ggt ctg ctg agt gca cgt gat        432
Thr Gly Phe Gln Leu Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp           
    130                 135                 140                           

ttt ctg gca agc ctg gca ttt cgt gtt ttt cag tgt acc cag tat att        480
Phe Leu Ala Ser Leu Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile           
145                 150                 155                 160           

cgt cat gcc agc agc ccg atg cat agt ccg gaa ccg gat tgt tgt cat        528
Arg His Ala Ser Ser Pro Met His Ser Pro Glu Pro Asp Cys Cys His           
                165                 170                 175               

gaa ctg ctg ggt cat gtt ccg atg ctg gca gat cgt acc ttt gca cag        576
Glu Leu Leu Gly His Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln           
            180                 185                 190                   

ttt agc cag gat att ggt ctg gca tca ctg ggt gca agt gat gaa gaa        624
Phe Ser Gln Asp Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu           
        195                 200                 205                       

atc gaa aaa ctg agc acc gtg tat tgg ttt acc gtt gaa ttt ggt ctg        672
Ile Glu Lys Leu Ser Thr Val Tyr Trp Phe Thr Val Glu Phe Gly Leu           
    210                 215                 220                           

tgc aaa cag aat ggt gaa ctg aaa gca tat ggt gcc ggt ctg ctg tca        720
Cys Lys Gln Asn Gly Glu Leu Lys Ala Tyr Gly Ala Gly Leu Leu Ser           
225                 230                 235                 240           

agc tat ggc gaa ctg ctg cat agc ctg agc gaa gaa ccg gaa gtt cgt        768
Ser Tyr Gly Glu Leu Leu His Ser Leu Ser Glu Glu Pro Glu Val Arg           
                245                 250                 255               

gca ttt gat ccg gat acc gca gcc gtt cag ccg tat cag gac cag acc        816
Ala Phe Asp Pro Asp Thr Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr           
            260                 265                 270                   

tat cag ccg gtt tat ttt gtt agc gaa agc ttc aat gac gcc aaa gat        864
Tyr Gln Pro Val Tyr Phe Val Ser Glu Ser Phe Asn Asp Ala Lys Asp           
        275                 280                 285                       

aaa ctg cgt aat tat gca agc cgt att cag cgt ccg ttt agc gtt aaa        912
Lys Leu Arg Asn Tyr Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys           
    290                 295                 300                           

ttc gat ccg tat acc ctg gca att gat gtt ctg gat tca ccg cat acc        960
Phe Asp Pro Tyr Thr Leu Ala Ile Asp Val Leu Asp Ser Pro His Thr           
305                 310                 315                 320           

att cag cgt agc ctg gaa ggt gtg cag gat gaa ctg cat aca ctg gca       1008
Ile Gln Arg Ser Leu Glu Gly Val Gln Asp Glu Leu His Thr Leu Ala           
                325                 330                 335               

cat gca ctg agc gca att agc taa                                       1032
His Ala Leu Ser Ala Ile Ser                                               
            340                                                           


<210>  44
<211>  343
<212>  PRT
<213>  synthetic

<400>  44

Met Lys Ser Ala Arg Glu Asp Lys Val Pro Trp Phe Pro Arg Lys Val 
1               5                   10                  15      


Ser Glu Leu Asp Lys Cys His His Leu Val Thr Lys Phe Asp Pro Asp 
            20                  25                  30          


Leu Asp Leu Asp His Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg 
        35                  40                  45              


Arg Lys Leu Ile Ala Glu Ile Ala Phe Gln Tyr Lys His Gly Glu Pro 
    50                  55                  60                  


Ile Pro His Val Glu Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu 
65                  70                  75                  80  


Val Tyr Val Thr Leu Lys Gly Leu Tyr Ala Thr His Ala Cys Arg Glu 
                85                  90                  95      


His Leu Glu Gly Phe Gln Leu Leu Glu Arg Tyr Cys Gly Tyr Arg Glu 
            100                 105                 110         


Asp Ser Ile Pro Gln Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg 
        115                 120                 125             


Thr Gly Phe Gln Leu Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp 
    130                 135                 140                 


Phe Leu Ala Ser Leu Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile 
145                 150                 155                 160 


Arg His Ala Ser Ser Pro Met His Ser Pro Glu Pro Asp Cys Cys His 
                165                 170                 175     


Glu Leu Leu Gly His Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln 
            180                 185                 190         


Phe Ser Gln Asp Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu 
        195                 200                 205             


Ile Glu Lys Leu Ser Thr Val Tyr Trp Phe Thr Val Glu Phe Gly Leu 
    210                 215                 220                 


Cys Lys Gln Asn Gly Glu Leu Lys Ala Tyr Gly Ala Gly Leu Leu Ser 
225                 230                 235                 240 


Ser Tyr Gly Glu Leu Leu His Ser Leu Ser Glu Glu Pro Glu Val Arg 
                245                 250                 255     


Ala Phe Asp Pro Asp Thr Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr 
            260                 265                 270         


Tyr Gln Pro Val Tyr Phe Val Ser Glu Ser Phe Asn Asp Ala Lys Asp 
        275                 280                 285             


Lys Leu Arg Asn Tyr Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys 
    290                 295                 300                 


Phe Asp Pro Tyr Thr Leu Ala Ile Asp Val Leu Asp Ser Pro His Thr 
305                 310                 315                 320 


Ile Gln Arg Ser Leu Glu Gly Val Gln Asp Glu Leu His Thr Leu Ala 
                325                 330                 335     


His Ala Leu Ser Ala Ile Ser 
            340             


<210>  45
<211>  342
<212>  DNA
<213>  Chromobacterium


<220>
<221>  CDS
<222>  (1)..(342)
<223>  cvPhhB

<400>  45
atg aca gga gta aaa atg aat ctg ctg gaa ctg agc tgt aca ccg cag         48
Met Thr Gly Val Lys Met Asn Leu Leu Glu Leu Ser Cys Thr Pro Gln           
1               5                   10                  15                

cat ggt cag agt ccg ctg gca gat aat acc gtg aaa cag ctg ctg agc         96
His Gly Gln Ser Pro Leu Ala Asp Asn Thr Val Lys Gln Leu Leu Ser           
            20                  25                  30                    

acc ctg ccg gat tgg gaa atc gtt ggt att gaa ctg cgt aaa acc tat        144
Thr Leu Pro Asp Trp Glu Ile Val Gly Ile Glu Leu Arg Lys Thr Tyr           
        35                  40                  45                        

cgt ttc gcc aac tat cat gaa acc atg gca ttt gtt aat gca ctg gca        192
Arg Phe Ala Asn Tyr His Glu Thr Met Ala Phe Val Asn Ala Leu Ala           
    50                  55                  60                            

tgg att gcc aat caa gaa gat cat cat ccg gat atg tcc gtg cat tat        240
Trp Ile Ala Asn Gln Glu Asp His His Pro Asp Met Ser Val His Tyr           
65                  70                  75                  80            

aat cgt gca gtt gtg aac ttc agc acc cat gat gca ggt ggt ctg acc        288
Asn Arg Ala Val Val Asn Phe Ser Thr His Asp Ala Gly Gly Leu Thr           
                85                  90                  95                

ctg aat gac ttc atc tgt gca gcg aaa acc gaa gca ctg ttt cgt cgt        336
Leu Asn Asp Phe Ile Cys Ala Ala Lys Thr Glu Ala Leu Phe Arg Arg           
            100                 105                 110                   

ccg taa                                                                342
Pro                                                                       
                                                                          


<210>  46
<211>  113
<212>  PRT
<213>  Chromobacterium

<400>  46

Met Thr Gly Val Lys Met Asn Leu Leu Glu Leu Ser Cys Thr Pro Gln 
1               5                   10                  15      


His Gly Gln Ser Pro Leu Ala Asp Asn Thr Val Lys Gln Leu Leu Ser 
            20                  25                  30          


Thr Leu Pro Asp Trp Glu Ile Val Gly Ile Glu Leu Arg Lys Thr Tyr 
        35                  40                  45              


Arg Phe Ala Asn Tyr His Glu Thr Met Ala Phe Val Asn Ala Leu Ala 
    50                  55                  60                  


Trp Ile Ala Asn Gln Glu Asp His His Pro Asp Met Ser Val His Tyr 
65                  70                  75                  80  


Asn Arg Ala Val Val Asn Phe Ser Thr His Asp Ala Gly Gly Leu Thr 
                85                  90                  95      


Leu Asn Asp Phe Ile Cys Ala Ala Lys Thr Glu Ala Leu Phe Arg Arg 
            100                 105                 110         


Pro 
    


<210>  47
<211>  669
<212>  DNA
<213>  E. coli


<220>
<221>  CDS
<222>  (1)..(669)
<223>  FolE(T198I)

<400>  47
atg cca tca ctc agt aaa gaa gcg gcc ctg gtt cat gaa gcg tta gtt         48
Met Pro Ser Leu Ser Lys Glu Ala Ala Leu Val His Glu Ala Leu Val           
1               5                   10                  15                

gcg cga gga ctg gaa aca ccg ctg cgc ccg ccc gtg cat gaa atg gat         96
Ala Arg Gly Leu Glu Thr Pro Leu Arg Pro Pro Val His Glu Met Asp           
            20                  25                  30                    

aac gaa acg cgc aaa agc ctt att gct ggt cat atg acc gaa atc atg        144
Asn Glu Thr Arg Lys Ser Leu Ile Ala Gly His Met Thr Glu Ile Met           
        35                  40                  45                        

cag ctg ctg aat ctc gac ctg gct gat gac agt ttg atg gaa acg ccg        192
Gln Leu Leu Asn Leu Asp Leu Ala Asp Asp Ser Leu Met Glu Thr Pro           
    50                  55                  60                            

cat cgc atc gct aaa atg tat gtc gat gaa att ttc tcc ggt ctg gat        240
His Arg Ile Ala Lys Met Tyr Val Asp Glu Ile Phe Ser Gly Leu Asp           
65                  70                  75                  80            

tac gcc aat ttc ccg aaa atc acc ctc att gaa aac aaa atg aag gtc        288
Tyr Ala Asn Phe Pro Lys Ile Thr Leu Ile Glu Asn Lys Met Lys Val           
                85                  90                  95                

gat gaa atg gtc acc gtg cgc gat atc act ctg acc agc acc tgt gaa        336
Asp Glu Met Val Thr Val Arg Asp Ile Thr Leu Thr Ser Thr Cys Glu           
            100                 105                 110                   

cac cat ttt gtt acc atc gat ggc aaa gcg acg gtg gcc tat atc ccg        384
His His Phe Val Thr Ile Asp Gly Lys Ala Thr Val Ala Tyr Ile Pro           
        115                 120                 125                       

aaa gat tcg gtc atc ggt ctg tca aaa att aac cgt att gtg cag ttc        432
Lys Asp Ser Val Ile Gly Leu Ser Lys Ile Asn Arg Ile Val Gln Phe           
    130                 135                 140                           

ttt gcc cag cgt ccg cag gta caa gaa cgt ctg acg cag caa att ctc        480
Phe Ala Gln Arg Pro Gln Val Gln Glu Arg Leu Thr Gln Gln Ile Leu           
145                 150                 155                 160           

att gcg cta caa acg ctg ctg ggc acc aat aac gtg gct gtc tct atc        528
Ile Ala Leu Gln Thr Leu Leu Gly Thr Asn Asn Val Ala Val Ser Ile           
                165                 170                 175               

gac gcg gtg cat tac tgc gtg aag gcg cgt ggc atc cgc gat gca acc        576
Asp Ala Val His Tyr Cys Val Lys Ala Arg Gly Ile Arg Asp Ala Thr           
            180                 185                 190                   

agt gca acc aca acg att tca ctt ggt gga ttg ttc aaa tcc agt cag        624
Ser Ala Thr Thr Thr Ile Ser Leu Gly Gly Leu Phe Lys Ser Ser Gln           
        195                 200                 205                       

aat acg cgc cac gag ttt ctg cgc gct gtg cgt cat cac aac tga            669
Asn Thr Arg His Glu Phe Leu Arg Ala Val Arg His His Asn                   
    210                 215                 220                           


<210>  48
<211>  222
<212>  PRT
<213>  E. coli

<400>  48

Met Pro Ser Leu Ser Lys Glu Ala Ala Leu Val His Glu Ala Leu Val 
1               5                   10                  15      


Ala Arg Gly Leu Glu Thr Pro Leu Arg Pro Pro Val His Glu Met Asp 
            20                  25                  30          


Asn Glu Thr Arg Lys Ser Leu Ile Ala Gly His Met Thr Glu Ile Met 
        35                  40                  45              


Gln Leu Leu Asn Leu Asp Leu Ala Asp Asp Ser Leu Met Glu Thr Pro 
    50                  55                  60                  


His Arg Ile Ala Lys Met Tyr Val Asp Glu Ile Phe Ser Gly Leu Asp 
65                  70                  75                  80  


Tyr Ala Asn Phe Pro Lys Ile Thr Leu Ile Glu Asn Lys Met Lys Val 
                85                  90                  95      


Asp Glu Met Val Thr Val Arg Asp Ile Thr Leu Thr Ser Thr Cys Glu 
            100                 105                 110         


His His Phe Val Thr Ile Asp Gly Lys Ala Thr Val Ala Tyr Ile Pro 
        115                 120                 125             


Lys Asp Ser Val Ile Gly Leu Ser Lys Ile Asn Arg Ile Val Gln Phe 
    130                 135                 140                 


Phe Ala Gln Arg Pro Gln Val Gln Glu Arg Leu Thr Gln Gln Ile Leu 
145                 150                 155                 160 


Ile Ala Leu Gln Thr Leu Leu Gly Thr Asn Asn Val Ala Val Ser Ile 
                165                 170                 175     


Asp Ala Val His Tyr Cys Val Lys Ala Arg Gly Ile Arg Asp Ala Thr 
            180                 185                 190         


Ser Ala Thr Thr Thr Ile Ser Leu Gly Gly Leu Phe Lys Ser Ser Gln 
        195                 200                 205             


Asn Thr Arg His Glu Phe Leu Arg Ala Val Arg His His Asn 
    210                 215                 220         


<210>  49
<211>  723
<212>  DNA
<213>  E. coli


<220>
<221>  CDS
<222>  (1)..(723)
<223>  FolM

<400>  49
atg ggt aaa acc cag tcc ttg cca ata tta att act ggc gga ggt cgc         48
Met Gly Lys Thr Gln Ser Leu Pro Ile Leu Ile Thr Gly Gly Gly Arg           
1               5                   10                  15                

cgc atc ggc ctc gcc ctc gca tgg cat ttc att aat caa aag caa ccg         96
Arg Ile Gly Leu Ala Leu Ala Trp His Phe Ile Asn Gln Lys Gln Pro           
            20                  25                  30                    

gtg att gtc agc tat cgg acg cac tat ccc gcc att gat gga ctg att        144
Val Ile Val Ser Tyr Arg Thr His Tyr Pro Ala Ile Asp Gly Leu Ile           
        35                  40                  45                        

aag gca ggt gcg cag tgt att cag gct gat ttt tcg acc aac gac ggt        192
Lys Ala Gly Ala Gln Cys Ile Gln Ala Asp Phe Ser Thr Asn Asp Gly           
    50                  55                  60                            

gtg atg gcg ttt gcc gat gaa gta cta aaa agc acc cat ggt ctg cgt        240
Val Met Ala Phe Ala Asp Glu Val Leu Lys Ser Thr His Gly Leu Arg           
65                  70                  75                  80            

gct att ttg cat aac gcc agc gcg tgg atg gcg gaa aaa ccg gga gcg        288
Ala Ile Leu His Asn Ala Ser Ala Trp Met Ala Glu Lys Pro Gly Ala           
                85                  90                  95                

cca ctg acc gac gta ctg gct tgc atg atg cag atc cac gtt aat acc        336
Pro Leu Thr Asp Val Leu Ala Cys Met Met Gln Ile His Val Asn Thr           
            100                 105                 110                   

cca tac ctg ctc aac cat gct ctg gaa aga tta ctg cgt ggg cac gga        384
Pro Tyr Leu Leu Asn His Ala Leu Glu Arg Leu Leu Arg Gly His Gly           
        115                 120                 125                       

cac gcc gcc agc gat atc att cac ttt acc gat tat gtg gtg gag cgc        432
His Ala Ala Ser Asp Ile Ile His Phe Thr Asp Tyr Val Val Glu Arg           
    130                 135                 140                           

ggt agc gac aaa cat att gcg tat gct gca agc aaa gcg gca ctg gat        480
Gly Ser Asp Lys His Ile Ala Tyr Ala Ala Ser Lys Ala Ala Leu Asp           
145                 150                 155                 160           

aat atg acc cgc tcg ttt gcc cgc aag ctg gca ccg gaa gtg aaa gtg        528
Asn Met Thr Arg Ser Phe Ala Arg Lys Leu Ala Pro Glu Val Lys Val           
                165                 170                 175               

aat tct att gcg cca tcg ctg atc ctg ttt aat gaa cat gat gat gct        576
Asn Ser Ile Ala Pro Ser Leu Ile Leu Phe Asn Glu His Asp Asp Ala           
            180                 185                 190                   

gaa tat cga caa cag gcg ctg aat aaa tca ctg atg aaa acc gcg cct        624
Glu Tyr Arg Gln Gln Ala Leu Asn Lys Ser Leu Met Lys Thr Ala Pro           
        195                 200                 205                       

ggc gag aaa gaa gtg atc gac ctg gtc gat tac tta ctt acc agc tgc        672
Gly Glu Lys Glu Val Ile Asp Leu Val Asp Tyr Leu Leu Thr Ser Cys           
    210                 215                 220                           

ttt gtc acc gga cgc agt ctc cca ctt gat ggc ggt cgt cat ctg cgt        720
Phe Val Thr Gly Arg Ser Leu Pro Leu Asp Gly Gly Arg His Leu Arg           
225                 230                 235                 240           

taa                                                                    723


<210>  50
<211>  240
<212>  PRT
<213>  E. coli

<400>  50

Met Gly Lys Thr Gln Ser Leu Pro Ile Leu Ile Thr Gly Gly Gly Arg 
1               5                   10                  15      


Arg Ile Gly Leu Ala Leu Ala Trp His Phe Ile Asn Gln Lys Gln Pro 
            20                  25                  30          


Val Ile Val Ser Tyr Arg Thr His Tyr Pro Ala Ile Asp Gly Leu Ile 
        35                  40                  45              


Lys Ala Gly Ala Gln Cys Ile Gln Ala Asp Phe Ser Thr Asn Asp Gly 
    50                  55                  60                  


Val Met Ala Phe Ala Asp Glu Val Leu Lys Ser Thr His Gly Leu Arg 
65                  70                  75                  80  


Ala Ile Leu His Asn Ala Ser Ala Trp Met Ala Glu Lys Pro Gly Ala 
                85                  90                  95      


Pro Leu Thr Asp Val Leu Ala Cys Met Met Gln Ile His Val Asn Thr 
            100                 105                 110         


Pro Tyr Leu Leu Asn His Ala Leu Glu Arg Leu Leu Arg Gly His Gly 
        115                 120                 125             


His Ala Ala Ser Asp Ile Ile His Phe Thr Asp Tyr Val Val Glu Arg 
    130                 135                 140                 


Gly Ser Asp Lys His Ile Ala Tyr Ala Ala Ser Lys Ala Ala Leu Asp 
145                 150                 155                 160 


Asn Met Thr Arg Ser Phe Ala Arg Lys Leu Ala Pro Glu Val Lys Val 
                165                 170                 175     


Asn Ser Ile Ala Pro Ser Leu Ile Leu Phe Asn Glu His Asp Asp Ala 
            180                 185                 190         


Glu Tyr Arg Gln Gln Ala Leu Asn Lys Ser Leu Met Lys Thr Ala Pro 
        195                 200                 205             


Gly Glu Lys Glu Val Ile Asp Leu Val Asp Tyr Leu Leu Thr Ser Cys 
    210                 215                 220                 


Phe Val Thr Gly Arg Ser Leu Pro Leu Asp Gly Gly Arg His Leu Arg 
225                 230                 235                 240 


<210>  51
<211>  5259
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (1)..(5259)
<223>  ompA-BBI_lac_HiBiT fusion

<400>  51
atg aaa aag aca gct atc gcg att gca gtg gca ctg gct ggt ttc gct         48
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala           
1               5                   10                  15                

acc gtt gcg caa gct gtc gag gac gcc acc cga tcc gac tcc acc acg         96
Thr Val Ala Gln Ala Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr           
            20                  25                  30                    

cag atg agc tcc acg ccg gag gtg gtc tac tcc agc gcc gtg gat tcc        144
Gln Met Ser Ser Thr Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser           
        35                  40                  45                        

aag cag aat cgc acc tcg gat ttc gac gcc aac tgg aag ttc atg ctg        192
Lys Gln Asn Arg Thr Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu           
    50                  55                  60                            

tcc gat tcc gtg cag gcg cag gat ccg gcg ttc gac gat tcg gcc tgg        240
Ser Asp Ser Val Gln Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp           
65                  70                  75                  80            

cag cag gtc gac ctg ccg cat gac tac agc atc acg cag aag tat tcg        288
Gln Gln Val Asp Leu Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser           
                85                  90                  95                

cag agc aac gag gcc gaa agc gca tac ctt ccc ggc ggc acc ggc tgg        336
Gln Ser Asn Glu Ala Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp           
            100                 105                 110                   

tac cgc aag tcc ttc acc atc gac cgg gac ctc gcc ggc aag cgc atc        384
Tyr Arg Lys Ser Phe Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile           
        115                 120                 125                       

gcc atc aac ttc gac ggc gtg tac atg aac gcc acc gtc tgg ttc aac        432
Ala Ile Asn Phe Asp Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn           
    130                 135                 140                           

ggc gtc aag ctc ggc acc cat ccg tac ggc tac tcg ccg ttc tcc ttc        480
Gly Val Lys Leu Gly Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe           
145                 150                 155                 160           

gac ctg acc ggc aac gcc aag ttc ggt ggg gag aac acc atc gtc gtc        528
Asp Leu Thr Gly Asn Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val           
                165                 170                 175               

aag gtc gag aac agg ctg ccg tcc agc cgc tgg tac tcc ggc tcc ggc        576
Lys Val Glu Asn Arg Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly           
            180                 185                 190                   

atc tac cgc gac gtc acc ctc acc gtc acc gac ggc gtg cac gtc ggc        624
Ile Tyr Arg Asp Val Thr Leu Thr Val Thr Asp Gly Val His Val Gly           
        195                 200                 205                       

aat aac ggc gtg gcc atc aag acc ccg agc ctc gcc acc caa aac ggc        672
Asn Asn Gly Val Ala Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly           
    210                 215                 220                           

ggc gac gtg acg atg aac ctc acc acc aag gtc gcc aac gac acc gag        720
Gly Asp Val Thr Met Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu           
225                 230                 235                 240           

gcc gcg gcg aac atc acc ctc aag cag acc gtg ttc ccc aag gga ggc        768
Ala Ala Ala Asn Ile Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly           
                245                 250                 255               

aag acc gac gcc gcc atc ggc acc gtc acc acc gca tcc aag tcc atc        816
Lys Thr Asp Ala Ala Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile           
            260                 265                 270                   

gcg gcc ggt gcc agc gcg gac gtg acc tcc acg atc acc gcc gct tcg        864
Ala Ala Gly Ala Ser Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser           
        275                 280                 285                       

ccc aag ctg tgg agc atc aag aac ccg aac ctg tac acc gtg cgc acc        912
Pro Lys Leu Trp Ser Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr           
    290                 295                 300                           

gaa gtg ctc aac ggc ggc aag gtg ctc gac act tac gac acc gaa tat        960
Glu Val Leu Asn Gly Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr           
305                 310                 315                 320           

ggc ttc cgc tgg acc ggc ttc gat gcg acc agc ggt ttc tcg ctc aac       1008
Gly Phe Arg Trp Thr Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn           
                325                 330                 335               

ggc gag aaa gtc aag ctc aag ggc gtc tca atg cat cat gac cag gga       1056
Gly Glu Lys Val Lys Leu Lys Gly Val Ser Met His His Asp Gln Gly           
            340                 345                 350                   

tcg ctc ggc gcg gtc gcc aac cgc cgc gcc atc gag cgc cag gtc gag       1104
Ser Leu Gly Ala Val Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu           
        355                 360                 365                       

att ctc cag aag atg ggc gtc aac tcg atc cgc acc acg cac aac ccc       1152
Ile Leu Gln Lys Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro           
    370                 375                 380                           

gca gcc aag gcg ctg att gac gtc tgc aac gag aag ggc gtc ctc gtg       1200
Ala Ala Lys Ala Leu Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val           
385                 390                 395                 400           

gtc gaa gag gtc ttc gac atg tgg aac cgg tcg aag aac ggc aac acc       1248
Val Glu Glu Val Phe Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr           
                405                 410                 415               

gag gat tac ggc aag tgg ttc ggc cag gcc atc gcc ggt gac aac gcc       1296
Glu Asp Tyr Gly Lys Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala           
            420                 425                 430                   

gtc ctg ggt ggc gac aag gac gag acc tgg gcc aag ttc gac ctg acc       1344
Val Leu Gly Gly Asp Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr           
        435                 440                 445                       

agc acc atc aac cgt gac agg aac gcc ccg tcc gtc atc atg tgg tcg       1392
Ser Thr Ile Asn Arg Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser           
    450                 455                 460                           

ctc ggc aac gag atg atg gaa ggc atc agc ggc agc gtc tcg ggc ttc       1440
Leu Gly Asn Glu Met Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe           
465                 470                 475                 480           

ccg gct acc tcc gcc aag ctg gtc gca tgg acg aag gcc gcg gac agc       1488
Pro Ala Thr Ser Ala Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser           
                485                 490                 495               

acc cgc ccg atg acc tac ggc gac aac aag atc aag gcc aac tgg aac       1536
Thr Arg Pro Met Thr Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn           
            500                 505                 510                   

gag tcg aac acc atg ggc gac aac ctg acc gcc aac ggc ggc gtg gtc       1584
Glu Ser Asn Thr Met Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val           
        515                 520                 525                       

ggc acc aac tac tcc gac ggc gcg aac tac gac aag atc cgc acg acc       1632
Gly Thr Asn Tyr Ser Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr           
    530                 535                 540                           

cac ccc tca tgg gcc atc tat ggt tcc gag acg gcg tcc gcc atc aac       1680
His Pro Ser Trp Ala Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn           
545                 550                 555                 560           

agc cga ggc atc tac aac cgc acc acc ggc ggc gcc cag tca agc gac       1728
Ser Arg Gly Ile Tyr Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp           
                565                 570                 575               

aag cag ctg acc agc tat gac aat tcc gca gtc ggc tgg ggc gcc gtc       1776
Lys Gln Leu Thr Ser Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val           
            580                 585                 590                   

gcc agc tcc gcc tgg tac gac gtg gtc cag cgc gat ttc gtc gcc ggc       1824
Ala Ser Ser Ala Trp Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly           
        595                 600                 605                       

aca tac gtg tgg acc ggc ttc gac tac ctc ggc gaa ccc acc ccg tgg       1872
Thr Tyr Val Trp Thr Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp           
    610                 615                 620                           

aac ggc acc ggc tcc ggc gcc gtg ggc tcc tgg ccg tcg ccg aag aac       1920
Asn Gly Thr Gly Ser Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn           
625                 630                 635                 640           

tcg tac ttc ggc atc gtc gac acc gca ggc ttc ccg aag gac acc tat       1968
Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr           
                645                 650                 655               

tac ttc tat cag agc cag tgg aac gac gac gtg cac acg ctg cac atc       2016
Tyr Phe Tyr Gln Ser Gln Trp Asn Asp Asp Val His Thr Leu His Ile           
            660                 665                 670                   

ctc ccc gca tgg aac gag aac gtc gtc gcc aag ggc tcc ggc aac aac       2064
Leu Pro Ala Trp Asn Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn           
        675                 680                 685                       

gtg ccg gtc gtc gtc tac acc gac gcg gcc aag gtc aag ctg tac ttc       2112
Val Pro Val Val Val Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe           
    690                 695                 700                           

aca ccg aag ggc agt acc gaa aag cga ctg atc gga gag aag tcc ttc       2160
Thr Pro Lys Gly Ser Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe           
705                 710                 715                 720           

acc aag aag acc acc gcg gcc gga tac acc tat cag gtc tac gag ggc       2208
Thr Lys Lys Thr Thr Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly           
                725                 730                 735               

tcc gac aag gac tcc acc gcc cac aag aac atg tac ctg acc tgg aac       2256
Ser Asp Lys Asp Ser Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn           
            740                 745                 750                   

gtg ccg tgg gcc gag ggc acc atc tcc gcc gaa gca tac gac gag aac       2304
Val Pro Trp Ala Glu Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn           
        755                 760                 765                       

aac agg ctg atc ccc gag ggg tcc acc gag ggc aac gcg tcg gtg acc       2352
Asn Arg Leu Ile Pro Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr           
    770                 775                 780                           

acc acc ggc aag gcc gcg aag ctt aaa gcc gat gcc gac cgc aag acg       2400
Thr Thr Gly Lys Ala Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr           
785                 790                 795                 800           

atc acc gcg gac ggc aag gac ctg tcg tac atc gag gtc gac gtg acc       2448
Ile Thr Ala Asp Gly Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr           
                805                 810                 815               

gac gcc aac ggc cat atc gtc ccc gat gcc gcc aac cgc gtc acc ttc       2496
Asp Ala Asn Gly His Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe           
            820                 825                 830                   

gac gtc aag ggc gcc ggc aaa ctg gtc ggc gtc gac aac ggc agc tcg       2544
Asp Val Lys Gly Ala Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser           
        835                 840                 845                       

ccg gat cac gac tcc tat cag gcc gac aac cgc aag gcg ttc agc ggc       2592
Pro Asp His Asp Ser Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly           
    850                 855                 860                           

aag gtg ctc gcc atc gtc cag tcc acc aag gag gcg ggc gag atc acc       2640
Lys Val Leu Ala Ile Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr           
865                 870                 875                 880           

gtc acc gcc aag gcc gac ggt ctg caa tca tcc aca gtg aag atc gcc       2688
Val Thr Ala Lys Ala Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala           
                885                 890                 895               

acc acc gcc gtc ccc ggc acc agc acc gag aag acg gtc cgc agc ttc       2736
Thr Thr Ala Val Pro Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe           
            900                 905                 910                   

tac tac tcg cgc aac tac tac gtc aag acc ggc aac aag ccg att ctg       2784
Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu           
        915                 920                 925                       

ccg agt gat gtc gag gtg cgc tac tcc gac ggc acg tcg gac cgt cag       2832
Pro Ser Asp Val Glu Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln           
    930                 935                 940                           

aac gtc aca tgg gac gca gtc agc gac gac cag atc gcc aag gcc ggt       2880
Asn Val Thr Trp Asp Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly           
945                 950                 955                 960           

tcg ttc agc gtg gcc ggc acg gtc gcc ggg cag aag atc tcc gtg cgc       2928
Ser Phe Ser Val Ala Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg           
                965                 970                 975               

gtg acg atg atc gac gag atc ggt gcg ctg ctc aac tat tcg gcc agc       2976
Val Thr Met Ile Asp Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser           
            980                 985                 990                   

aca ccg gtc ggc acg ccc gcc gtg  ctg cct ggc tcg cgt  ccg gcc gtg     3024
Thr Pro Val Gly Thr Pro Ala Val  Leu Pro Gly Ser Arg  Pro Ala Val         
        995                 1000                 1005                     

ctg ccc  gac ggc acc gtg acc  agc gcg aac ttc gcc  gtc cac tgg        3069
Leu Pro  Asp Gly Thr Val Thr  Ser Ala Asn Phe Ala  Val His Trp            
    1010                 1015                 1020                        

acc aag  ccc gcc gac acc gtg  tac aac acg gcc ggc  acc gtc aag        3114
Thr Lys  Pro Ala Asp Thr Val  Tyr Asn Thr Ala Gly  Thr Val Lys            
    1025                 1030                 1035                        

gtc ccc  ggc acc gcc acc gtc  ttc ggc aag gag ttc  aag gtc acc        3159
Val Pro  Gly Thr Ala Thr Val  Phe Gly Lys Glu Phe  Lys Val Thr            
    1040                 1045                 1050                        

gcg acg  att cgc gtg cag cgg  tcg cag gtc acc atc  ggc agc agc        3204
Ala Thr  Ile Arg Val Gln Arg  Ser Gln Val Thr Ile  Gly Ser Ser            
    1055                 1060                 1065                        

gtc tcc  ggc aat gcg ctg cgc  ctg act cag aac atc  ccc gcc gac        3249
Val Ser  Gly Asn Ala Leu Arg  Leu Thr Gln Asn Ile  Pro Ala Asp            
    1070                 1075                 1080                        

aag cag  tcc gac acg ctg gac  gcc atc aag gac ggc  tcc acg acc        3294
Lys Gln  Ser Asp Thr Leu Asp  Ala Ile Lys Asp Gly  Ser Thr Thr            
    1085                 1090                 1095                        

gtc gac  gcc aat acc ggc ggc  ggc gcg aac ccg tca  gca tgg acc        3339
Val Asp  Ala Asn Thr Gly Gly  Gly Ala Asn Pro Ser  Ala Trp Thr            
    1100                 1105                 1110                        

aac tgg  gcg tac tcg aag gcc  ggc cac aac acc gcc  gag atc acc        3384
Asn Trp  Ala Tyr Ser Lys Ala  Gly His Asn Thr Ala  Glu Ile Thr            
    1115                 1120                 1125                        

ttc gag  tac gcg acc gag cag  cag ctc ggc cag att  gtc atg tac        3429
Phe Glu  Tyr Ala Thr Glu Gln  Gln Leu Gly Gln Ile  Val Met Tyr            
    1130                 1135                 1140                        

ttc ttc  cgc gac agc aac gcg  gtg agg ttc ccc gac  gcc ggc aag        3474
Phe Phe  Arg Asp Ser Asn Ala  Val Arg Phe Pro Asp  Ala Gly Lys            
    1145                 1150                 1155                        

acg aag  atc cag atc tcc gcg  gac ggc aag aac tgg  acg gat ctc        3519
Thr Lys  Ile Gln Ile Ser Ala  Asp Gly Lys Asn Trp  Thr Asp Leu            
    1160                 1165                 1170                        

gct gcc  acg gag acc atc gcg  gcc cag gag tcg tcc  gac cga gtc        3564
Ala Ala  Thr Glu Thr Ile Ala  Ala Gln Glu Ser Ser  Asp Arg Val            
    1175                 1180                 1185                        

aag ccg  tac acc tat gac ttc  gct ccg gtg gga gcc  acg ttc gtc        3609
Lys Pro  Tyr Thr Tyr Asp Phe  Ala Pro Val Gly Ala  Thr Phe Val            
    1190                 1195                 1200                        

aag gtc  acg gtc acc aac gcc  gac acc aca acc ccc  agc ggc gtg        3654
Lys Val  Thr Val Thr Asn Ala  Asp Thr Thr Thr Pro  Ser Gly Val            
    1205                 1210                 1215                        

gtc tgc  gcc ggc ctg acc gag  atc gag ctg aag acc  gcg acc agc        3699
Val Cys  Ala Gly Leu Thr Glu  Ile Glu Leu Lys Thr  Ala Thr Ser            
    1220                 1225                 1230                        

aag ttc  gtc acg aac acg tcc  gcc gcg ctc tcg tcg  ctg aca gtg        3744
Lys Phe  Val Thr Asn Thr Ser  Ala Ala Leu Ser Ser  Leu Thr Val            
    1235                 1240                 1245                        

aac ggc  acg aag gtc tcc gac  tcc gtg ctc gcc gcc  ggc tcc tac        3789
Asn Gly  Thr Lys Val Ser Asp  Ser Val Leu Ala Ala  Gly Ser Tyr            
    1250                 1255                 1260                        

aac acg  ccc gcg atc atc gcg  gac gtc aaa gcc gag  ggc gaa ggc        3834
Asn Thr  Pro Ala Ile Ile Ala  Asp Val Lys Ala Glu  Gly Glu Gly            
    1265                 1270                 1275                        

aac gcc  agc gtc acc gtg ctg  ccc gcg cac gac aac  gtg atc cgc        3879
Asn Ala  Ser Val Thr Val Leu  Pro Ala His Asp Asn  Val Ile Arg            
    1280                 1285                 1290                        

gtg atc  acc gag tcc gag gac  cac gtc acg cgc aag  acc ttc acc        3924
Val Ile  Thr Glu Ser Glu Asp  His Val Thr Arg Lys  Thr Phe Thr            
    1295                 1300                 1305                        

atc aac  ctg ggc acg gag cag  gaa ttc ccc gca gac  tcc gat gaa        3969
Ile Asn  Leu Gly Thr Glu Gln  Glu Phe Pro Ala Asp  Ser Asp Glu            
    1310                 1315                 1320                        

cgc gac  tac ccg gcc gcc gac  atg acg gtc acc gtg  ggc agc gaa        4014
Arg Asp  Tyr Pro Ala Ala Asp  Met Thr Val Thr Val  Gly Ser Glu            
    1325                 1330                 1335                        

cag acg  tcc ggc acc gcg acc  gaa ggc ccg aag aaa  ttc gcg gtc        4059
Gln Thr  Ser Gly Thr Ala Thr  Glu Gly Pro Lys Lys  Phe Ala Val            
    1340                 1345                 1350                        

gac ggc  aac acc agc acg tac  tgg cat tcc aac tgg  acg ccc acc        4104
Asp Gly  Asn Thr Ser Thr Tyr  Trp His Ser Asn Trp  Thr Pro Thr            
    1355                 1360                 1365                        

acc gtg  aac gac ctg tgg atc  gcc ttc gag ctc cag  aaa ccc acc        4149
Thr Val  Asn Asp Leu Trp Ile  Ala Phe Glu Leu Gln  Lys Pro Thr            
    1370                 1375                 1380                        

aag ctc  gac gcg ctg cgc tac  ctg ccg cgc ccc gcg  ggc agc aag        4194
Lys Leu  Asp Ala Leu Arg Tyr  Leu Pro Arg Pro Ala  Gly Ser Lys            
    1385                 1390                 1395                        

aac ggc  tcc gtc acc gaa tac  aag gtt cag gtc agc  gat gac ggc        4239
Asn Gly  Ser Val Thr Glu Tyr  Lys Val Gln Val Ser  Asp Asp Gly            
    1400                 1405                 1410                        

acc aac  tgg acc gac gcg ggc  tcc ggc aca tgg acc  acc gat tac        4284
Thr Asn  Trp Thr Asp Ala Gly  Ser Gly Thr Trp Thr  Thr Asp Tyr            
    1415                 1420                 1425                        

ggc tgg  aag ctc gcc gag ttc  aat cag ccg gtg acc  acc aag cac        4329
Gly Trp  Lys Leu Ala Glu Phe  Asn Gln Pro Val Thr  Thr Lys His            
    1430                 1435                 1440                        

gtg cgg  ctc aag gcc gtc cac  acc tat gcg gat tcc  ggc aac gac        4374
Val Arg  Leu Lys Ala Val His  Thr Tyr Ala Asp Ser  Gly Asn Asp            
    1445                 1450                 1455                        

aag ttc  atg tcc gcc tcc gaa  atc cgc ctg cgc aag  gcc gtc gac        4419
Lys Phe  Met Ser Ala Ser Glu  Ile Arg Leu Arg Lys  Ala Val Asp            
    1460                 1465                 1470                        

acc acc  gac atc agc ggc gcg  acc gtg acc gtg ccc  gcc aag ctg        4464
Thr Thr  Asp Ile Ser Gly Ala  Thr Val Thr Val Pro  Ala Lys Leu            
    1475                 1480                 1485                        

acc gtc  gac cgg gtg gac gcc  gac cat ccc gcc acc  ttc gcc acg        4509
Thr Val  Asp Arg Val Asp Ala  Asp His Pro Ala Thr  Phe Ala Thr            
    1490                 1495                 1500                        

aag gac  gtg acg gtg acg ttg  ggc gac gcc acg ctg  cgc tac ggc        4554
Lys Asp  Val Thr Val Thr Leu  Gly Asp Ala Thr Leu  Arg Tyr Gly            
    1505                 1510                 1515                        

gtg gac  tac ctg ctc gac tac  gcg ggc aac acc gcc  gtc ggc aag        4599
Val Asp  Tyr Leu Leu Asp Tyr  Ala Gly Asn Thr Ala  Val Gly Lys            
    1520                 1525                 1530                        

gcc acg  gtg acc gtg cgc ggc  atc gac aag tac tcc  ggc acc gtc        4644
Ala Thr  Val Thr Val Arg Gly  Ile Asp Lys Tyr Ser  Gly Thr Val            
    1535                 1540                 1545                        

gcc aag  acg ttc acc atc gaa  ctg aag aac gcc ccg  gcg ccg gaa        4689
Ala Lys  Thr Phe Thr Ile Glu  Leu Lys Asn Ala Pro  Ala Pro Glu            
    1550                 1555                 1560                        

ccg acg  ctg acc tcg gtg agc  gtc aag acc aag cct  tcc aag ctg        4734
Pro Thr  Leu Thr Ser Val Ser  Val Lys Thr Lys Pro  Ser Lys Leu            
    1565                 1570                 1575                        

acc tat  gtg gtc ggc gac gcg  ttc gac ccg gca gga  ctg gtg ctg        4779
Thr Tyr  Val Val Gly Asp Ala  Phe Asp Pro Ala Gly  Leu Val Leu            
    1580                 1585                 1590                        

cag cac  gac aga cag gcc gat  cgc ccc cca cag cca  ctt gtt gga        4824
Gln His  Asp Arg Gln Ala Asp  Arg Pro Pro Gln Pro  Leu Val Gly            
    1595                 1600                 1605                        

gaa cag  gcc gac gaa cgc gga  ctg acg tgc gga acg  cga tgc gat        4869
Glu Gln  Ala Asp Glu Arg Gly  Leu Thr Cys Gly Thr  Arg Cys Asp            
    1610                 1615                 1620                        

cgc gtt  gaa cag ctg cgc aaa  cac gag aat cgt gaa  gcc cat cgt        4914
Arg Val  Glu Gln Leu Arg Lys  His Glu Asn Arg Glu  Ala His Arg            
    1625                 1630                 1635                        

acg ggc  ctc gat cat ctg gaa  ttc gtg ggt gcc gcc  gat gga gcg        4959
Thr Gly  Leu Asp His Leu Glu  Phe Val Gly Ala Ala  Asp Gly Ala            
    1640                 1645                 1650                        

gtc ggt  gaa cag gcc acc ttc  aag gtg cat gtc cat  gcc gat caa        5004
Val Gly  Glu Gln Ala Thr Phe  Lys Val His Val His  Ala Asp Gln            
    1655                 1660                 1665                        

ggt gac  ggc cgc cat gat gat  gcc gat gaa cgc gat  atc gat cca        5049
Gly Asp  Gly Arg His Asp Asp  Ala Asp Glu Arg Asp  Ile Asp Pro            
    1670                 1675                 1680                        

cat gtc  cct gtc gat cac gcg  gtc ggt gag ctt gcg  cgg gct gcg        5094
His Val  Pro Val Asp His Ala  Val Gly Glu Leu Ala  Arg Ala Ala            
    1685                 1690                 1695                        

tgc cat  cac gtc atc ggt ctg  cgg gtc gac acc cat  cgc ctc aag        5139
Cys His  His Val Ile Gly Leu  Arg Val Asp Thr His  Arg Leu Lys            
    1700                 1705                 1710                        

gca tcc  ggc ttc cag atc ccc  gcc gac gac atg gcc  gag atc gac        5184
Ala Ser  Gly Phe Gln Ile Pro  Ala Asp Asp Met Ala  Glu Ile Asp            
    1715                 1720                 1725                        

cgc atc  acc ggc ttc cac cgc  ttc gag cgc cac gtc  ggc gtg agc        5229
Arg Ile  Thr Gly Phe His Arg  Phe Glu Arg His Val  Gly Val Ser            
    1730                 1735                 1740                        

ggc tgg  cgg ctg ttc aag aag  att agc tga                             5259
Gly Trp  Arg Leu Phe Lys Lys  Ile Ser                                     
    1745                 1750                                             


<210>  52
<211>  1752
<212>  PRT
<213>  synthetic

<400>  52

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr 
            20                  25                  30          


Gln Met Ser Ser Thr Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser 
        35                  40                  45              


Lys Gln Asn Arg Thr Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu 
    50                  55                  60                  


Ser Asp Ser Val Gln Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp 
65                  70                  75                  80  


Gln Gln Val Asp Leu Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser 
                85                  90                  95      


Gln Ser Asn Glu Ala Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp 
            100                 105                 110         


Tyr Arg Lys Ser Phe Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile 
        115                 120                 125             


Ala Ile Asn Phe Asp Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn 
    130                 135                 140                 


Gly Val Lys Leu Gly Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe 
145                 150                 155                 160 


Asp Leu Thr Gly Asn Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val 
                165                 170                 175     


Lys Val Glu Asn Arg Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly 
            180                 185                 190         


Ile Tyr Arg Asp Val Thr Leu Thr Val Thr Asp Gly Val His Val Gly 
        195                 200                 205             


Asn Asn Gly Val Ala Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly 
    210                 215                 220                 


Gly Asp Val Thr Met Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu 
225                 230                 235                 240 


Ala Ala Ala Asn Ile Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly 
                245                 250                 255     


Lys Thr Asp Ala Ala Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile 
            260                 265                 270         


Ala Ala Gly Ala Ser Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser 
        275                 280                 285             


Pro Lys Leu Trp Ser Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr 
    290                 295                 300                 


Glu Val Leu Asn Gly Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr 
305                 310                 315                 320 


Gly Phe Arg Trp Thr Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn 
                325                 330                 335     


Gly Glu Lys Val Lys Leu Lys Gly Val Ser Met His His Asp Gln Gly 
            340                 345                 350         


Ser Leu Gly Ala Val Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu 
        355                 360                 365             


Ile Leu Gln Lys Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro 
    370                 375                 380                 


Ala Ala Lys Ala Leu Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val 
385                 390                 395                 400 


Val Glu Glu Val Phe Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr 
                405                 410                 415     


Glu Asp Tyr Gly Lys Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala 
            420                 425                 430         


Val Leu Gly Gly Asp Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr 
        435                 440                 445             


Ser Thr Ile Asn Arg Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser 
    450                 455                 460                 


Leu Gly Asn Glu Met Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe 
465                 470                 475                 480 


Pro Ala Thr Ser Ala Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser 
                485                 490                 495     


Thr Arg Pro Met Thr Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn 
            500                 505                 510         


Glu Ser Asn Thr Met Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val 
        515                 520                 525             


Gly Thr Asn Tyr Ser Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr 
    530                 535                 540                 


His Pro Ser Trp Ala Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn 
545                 550                 555                 560 


Ser Arg Gly Ile Tyr Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp 
                565                 570                 575     


Lys Gln Leu Thr Ser Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val 
            580                 585                 590         


Ala Ser Ser Ala Trp Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly 
        595                 600                 605             


Thr Tyr Val Trp Thr Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp 
    610                 615                 620                 


Asn Gly Thr Gly Ser Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn 
625                 630                 635                 640 


Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr 
                645                 650                 655     


Tyr Phe Tyr Gln Ser Gln Trp Asn Asp Asp Val His Thr Leu His Ile 
            660                 665                 670         


Leu Pro Ala Trp Asn Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn 
        675                 680                 685             


Val Pro Val Val Val Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe 
    690                 695                 700                 


Thr Pro Lys Gly Ser Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe 
705                 710                 715                 720 


Thr Lys Lys Thr Thr Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly 
                725                 730                 735     


Ser Asp Lys Asp Ser Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn 
            740                 745                 750         


Val Pro Trp Ala Glu Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn 
        755                 760                 765             


Asn Arg Leu Ile Pro Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr 
    770                 775                 780                 


Thr Thr Gly Lys Ala Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr 
785                 790                 795                 800 


Ile Thr Ala Asp Gly Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr 
                805                 810                 815     


Asp Ala Asn Gly His Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe 
            820                 825                 830         


Asp Val Lys Gly Ala Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser 
        835                 840                 845             


Pro Asp His Asp Ser Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly 
    850                 855                 860                 


Lys Val Leu Ala Ile Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr 
865                 870                 875                 880 


Val Thr Ala Lys Ala Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala 
                885                 890                 895     


Thr Thr Ala Val Pro Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe 
            900                 905                 910         


Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu 
        915                 920                 925             


Pro Ser Asp Val Glu Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln 
    930                 935                 940                 


Asn Val Thr Trp Asp Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly 
945                 950                 955                 960 


Ser Phe Ser Val Ala Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg 
                965                 970                 975     


Val Thr Met Ile Asp Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser 
            980                 985                 990         


Thr Pro Val Gly Thr Pro Ala Val  Leu Pro Gly Ser Arg  Pro Ala Val 
        995                 1000                 1005             


Leu Pro  Asp Gly Thr Val Thr  Ser Ala Asn Phe Ala  Val His Trp 
    1010                 1015                 1020             


Thr Lys  Pro Ala Asp Thr Val  Tyr Asn Thr Ala Gly  Thr Val Lys 
    1025                 1030                 1035             


Val Pro  Gly Thr Ala Thr Val  Phe Gly Lys Glu Phe  Lys Val Thr 
    1040                 1045                 1050             


Ala Thr  Ile Arg Val Gln Arg  Ser Gln Val Thr Ile  Gly Ser Ser 
    1055                 1060                 1065             


Val Ser  Gly Asn Ala Leu Arg  Leu Thr Gln Asn Ile  Pro Ala Asp 
    1070                 1075                 1080             


Lys Gln  Ser Asp Thr Leu Asp  Ala Ile Lys Asp Gly  Ser Thr Thr 
    1085                 1090                 1095             


Val Asp  Ala Asn Thr Gly Gly  Gly Ala Asn Pro Ser  Ala Trp Thr 
    1100                 1105                 1110             


Asn Trp  Ala Tyr Ser Lys Ala  Gly His Asn Thr Ala  Glu Ile Thr 
    1115                 1120                 1125             


Phe Glu  Tyr Ala Thr Glu Gln  Gln Leu Gly Gln Ile  Val Met Tyr 
    1130                 1135                 1140             


Phe Phe  Arg Asp Ser Asn Ala  Val Arg Phe Pro Asp  Ala Gly Lys 
    1145                 1150                 1155             


Thr Lys  Ile Gln Ile Ser Ala  Asp Gly Lys Asn Trp  Thr Asp Leu 
    1160                 1165                 1170             


Ala Ala  Thr Glu Thr Ile Ala  Ala Gln Glu Ser Ser  Asp Arg Val 
    1175                 1180                 1185             


Lys Pro  Tyr Thr Tyr Asp Phe  Ala Pro Val Gly Ala  Thr Phe Val 
    1190                 1195                 1200             


Lys Val  Thr Val Thr Asn Ala  Asp Thr Thr Thr Pro  Ser Gly Val 
    1205                 1210                 1215             


Val Cys  Ala Gly Leu Thr Glu  Ile Glu Leu Lys Thr  Ala Thr Ser 
    1220                 1225                 1230             


Lys Phe  Val Thr Asn Thr Ser  Ala Ala Leu Ser Ser  Leu Thr Val 
    1235                 1240                 1245             


Asn Gly  Thr Lys Val Ser Asp  Ser Val Leu Ala Ala  Gly Ser Tyr 
    1250                 1255                 1260             


Asn Thr  Pro Ala Ile Ile Ala  Asp Val Lys Ala Glu  Gly Glu Gly 
    1265                 1270                 1275             


Asn Ala  Ser Val Thr Val Leu  Pro Ala His Asp Asn  Val Ile Arg 
    1280                 1285                 1290             


Val Ile  Thr Glu Ser Glu Asp  His Val Thr Arg Lys  Thr Phe Thr 
    1295                 1300                 1305             


Ile Asn  Leu Gly Thr Glu Gln  Glu Phe Pro Ala Asp  Ser Asp Glu 
    1310                 1315                 1320             


Arg Asp  Tyr Pro Ala Ala Asp  Met Thr Val Thr Val  Gly Ser Glu 
    1325                 1330                 1335             


Gln Thr  Ser Gly Thr Ala Thr  Glu Gly Pro Lys Lys  Phe Ala Val 
    1340                 1345                 1350             


Asp Gly  Asn Thr Ser Thr Tyr  Trp His Ser Asn Trp  Thr Pro Thr 
    1355                 1360                 1365             


Thr Val  Asn Asp Leu Trp Ile  Ala Phe Glu Leu Gln  Lys Pro Thr 
    1370                 1375                 1380             


Lys Leu  Asp Ala Leu Arg Tyr  Leu Pro Arg Pro Ala  Gly Ser Lys 
    1385                 1390                 1395             


Asn Gly  Ser Val Thr Glu Tyr  Lys Val Gln Val Ser  Asp Asp Gly 
    1400                 1405                 1410             


Thr Asn  Trp Thr Asp Ala Gly  Ser Gly Thr Trp Thr  Thr Asp Tyr 
    1415                 1420                 1425             


Gly Trp  Lys Leu Ala Glu Phe  Asn Gln Pro Val Thr  Thr Lys His 
    1430                 1435                 1440             


Val Arg  Leu Lys Ala Val His  Thr Tyr Ala Asp Ser  Gly Asn Asp 
    1445                 1450                 1455             


Lys Phe  Met Ser Ala Ser Glu  Ile Arg Leu Arg Lys  Ala Val Asp 
    1460                 1465                 1470             


Thr Thr  Asp Ile Ser Gly Ala  Thr Val Thr Val Pro  Ala Lys Leu 
    1475                 1480                 1485             


Thr Val  Asp Arg Val Asp Ala  Asp His Pro Ala Thr  Phe Ala Thr 
    1490                 1495                 1500             


Lys Asp  Val Thr Val Thr Leu  Gly Asp Ala Thr Leu  Arg Tyr Gly 
    1505                 1510                 1515             


Val Asp  Tyr Leu Leu Asp Tyr  Ala Gly Asn Thr Ala  Val Gly Lys 
    1520                 1525                 1530             


Ala Thr  Val Thr Val Arg Gly  Ile Asp Lys Tyr Ser  Gly Thr Val 
    1535                 1540                 1545             


Ala Lys  Thr Phe Thr Ile Glu  Leu Lys Asn Ala Pro  Ala Pro Glu 
    1550                 1555                 1560             


Pro Thr  Leu Thr Ser Val Ser  Val Lys Thr Lys Pro  Ser Lys Leu 
    1565                 1570                 1575             


Thr Tyr  Val Val Gly Asp Ala  Phe Asp Pro Ala Gly  Leu Val Leu 
    1580                 1585                 1590             


Gln His  Asp Arg Gln Ala Asp  Arg Pro Pro Gln Pro  Leu Val Gly 
    1595                 1600                 1605             


Glu Gln  Ala Asp Glu Arg Gly  Leu Thr Cys Gly Thr  Arg Cys Asp 
    1610                 1615                 1620             


Arg Val  Glu Gln Leu Arg Lys  His Glu Asn Arg Glu  Ala His Arg 
    1625                 1630                 1635             


Thr Gly  Leu Asp His Leu Glu  Phe Val Gly Ala Ala  Asp Gly Ala 
    1640                 1645                 1650             


Val Gly  Glu Gln Ala Thr Phe  Lys Val His Val His  Ala Asp Gln 
    1655                 1660                 1665             


Gly Asp  Gly Arg His Asp Asp  Ala Asp Glu Arg Asp  Ile Asp Pro 
    1670                 1675                 1680             


His Val  Pro Val Asp His Ala  Val Gly Glu Leu Ala  Arg Ala Ala 
    1685                 1690                 1695             


Cys His  His Val Ile Gly Leu  Arg Val Asp Thr His  Arg Leu Lys 
    1700                 1705                 1710             


Ala Ser  Gly Phe Gln Ile Pro  Ala Asp Asp Met Ala  Glu Ile Asp 
    1715                 1720                 1725             


Arg Ile  Thr Gly Phe His Arg  Phe Glu Arg His Val  Gly Val Ser 
    1730                 1735                 1740             


Gly Trp  Arg Leu Phe Lys Lys  Ile Ser 
    1745                 1750         


<210>  53
<211>  5313
<212>  DNA
<213>  synthetic


<220>
<221>  CDS
<222>  (1)..(5313)
<223>  torA-BBI_lac_HiBiT fusion

<400>  53
atg aac aat aac gat ctc ttt cag gca tca cgt cgg cgt ttt ctg gca         48
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala           
1               5                   10                  15                

caa ctc ggc ggc tta acc gtc gcc ggg atg ctg ggg ccg tca ttg tta         96
Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu           
            20                  25                  30                    

acg ccg cga cgt gcg act gcg gtc gag gac gcc acc cga tcc gac tcc        144
Thr Pro Arg Arg Ala Thr Ala Val Glu Asp Ala Thr Arg Ser Asp Ser           
        35                  40                  45                        

acc acg cag atg agc tcc acg ccg gag gtg gtc tac tcc agc gcc gtg        192
Thr Thr Gln Met Ser Ser Thr Pro Glu Val Val Tyr Ser Ser Ala Val           
    50                  55                  60                            

gat tcc aag cag aat cgc acc tcg gat ttc gac gcc aac tgg aag ttc        240
Asp Ser Lys Gln Asn Arg Thr Ser Asp Phe Asp Ala Asn Trp Lys Phe           
65                  70                  75                  80            

atg ctg tcc gat tcc gtg cag gcg cag gat ccg gcg ttc gac gat tcg        288
Met Leu Ser Asp Ser Val Gln Ala Gln Asp Pro Ala Phe Asp Asp Ser           
                85                  90                  95                

gcc tgg cag cag gtc gac ctg ccg cat gac tac agc atc acg cag aag        336
Ala Trp Gln Gln Val Asp Leu Pro His Asp Tyr Ser Ile Thr Gln Lys           
            100                 105                 110                   

tat tcg cag agc aac gag gcc gaa agc gca tac ctt ccc ggc ggc acc        384
Tyr Ser Gln Ser Asn Glu Ala Glu Ser Ala Tyr Leu Pro Gly Gly Thr           
        115                 120                 125                       

ggc tgg tac cgc aag tcc ttc acc atc gac cgg gac ctc gcc ggc aag        432
Gly Trp Tyr Arg Lys Ser Phe Thr Ile Asp Arg Asp Leu Ala Gly Lys           
    130                 135                 140                           

cgc atc gcc atc aac ttc gac ggc gtg tac atg aac gcc acc gtc tgg        480
Arg Ile Ala Ile Asn Phe Asp Gly Val Tyr Met Asn Ala Thr Val Trp           
145                 150                 155                 160           

ttc aac ggc gtc aag ctc ggc acc cat ccg tac ggc tac tcg ccg ttc        528
Phe Asn Gly Val Lys Leu Gly Thr His Pro Tyr Gly Tyr Ser Pro Phe           
                165                 170                 175               

tcc ttc gac ctg acc ggc aac gcc aag ttc ggt ggg gag aac acc atc        576
Ser Phe Asp Leu Thr Gly Asn Ala Lys Phe Gly Gly Glu Asn Thr Ile           
            180                 185                 190                   

gtc gtc aag gtc gag aac agg ctg ccg tcc agc cgc tgg tac tcc ggc        624
Val Val Lys Val Glu Asn Arg Leu Pro Ser Ser Arg Trp Tyr Ser Gly           
        195                 200                 205                       

tcc ggc atc tac cgc gac gtc acc ctc acc gtc acc gac ggc gtg cac        672
Ser Gly Ile Tyr Arg Asp Val Thr Leu Thr Val Thr Asp Gly Val His           
    210                 215                 220                           

gtc ggc aat aac ggc gtg gcc atc aag acc ccg agc ctc gcc acc caa        720
Val Gly Asn Asn Gly Val Ala Ile Lys Thr Pro Ser Leu Ala Thr Gln           
225                 230                 235                 240           

aac ggc ggc gac gtg acg atg aac ctc acc acc aag gtc gcc aac gac        768
Asn Gly Gly Asp Val Thr Met Asn Leu Thr Thr Lys Val Ala Asn Asp           
                245                 250                 255               

acc gag gcc gcg gcg aac atc acc ctc aag cag acc gtg ttc ccc aag        816
Thr Glu Ala Ala Ala Asn Ile Thr Leu Lys Gln Thr Val Phe Pro Lys           
            260                 265                 270                   

gga ggc aag acc gac gcc gcc atc ggc acc gtc acc acc gca tcc aag        864
Gly Gly Lys Thr Asp Ala Ala Ile Gly Thr Val Thr Thr Ala Ser Lys           
        275                 280                 285                       

tcc atc gcg gcc ggt gcc agc gcg gac gtg acc tcc acg atc acc gcc        912
Ser Ile Ala Ala Gly Ala Ser Ala Asp Val Thr Ser Thr Ile Thr Ala           
    290                 295                 300                           

gct tcg ccc aag ctg tgg agc atc aag aac ccg aac ctg tac acc gtg        960
Ala Ser Pro Lys Leu Trp Ser Ile Lys Asn Pro Asn Leu Tyr Thr Val           
305                 310                 315                 320           

cgc acc gaa gtg ctc aac ggc ggc aag gtg ctc gac act tac gac acc       1008
Arg Thr Glu Val Leu Asn Gly Gly Lys Val Leu Asp Thr Tyr Asp Thr           
                325                 330                 335               

gaa tat ggc ttc cgc tgg acc ggc ttc gat gcg acc agc ggt ttc tcg       1056
Glu Tyr Gly Phe Arg Trp Thr Gly Phe Asp Ala Thr Ser Gly Phe Ser           
            340                 345                 350                   

ctc aac ggc gag aaa gtc aag ctc aag ggc gtc tca atg cat cat gac       1104
Leu Asn Gly Glu Lys Val Lys Leu Lys Gly Val Ser Met His His Asp           
        355                 360                 365                       

cag gga tcg ctc ggc gcg gtc gcc aac cgc cgc gcc atc gag cgc cag       1152
Gln Gly Ser Leu Gly Ala Val Ala Asn Arg Arg Ala Ile Glu Arg Gln           
    370                 375                 380                           

gtc gag att ctc cag aag atg ggc gtc aac tcg atc cgc acc acg cac       1200
Val Glu Ile Leu Gln Lys Met Gly Val Asn Ser Ile Arg Thr Thr His           
385                 390                 395                 400           

aac ccc gca gcc aag gcg ctg att gac gtc tgc aac gag aag ggc gtc       1248
Asn Pro Ala Ala Lys Ala Leu Ile Asp Val Cys Asn Glu Lys Gly Val           
                405                 410                 415               

ctc gtg gtc gaa gag gtc ttc gac atg tgg aac cgg tcg aag aac ggc       1296
Leu Val Val Glu Glu Val Phe Asp Met Trp Asn Arg Ser Lys Asn Gly           
            420                 425                 430                   

aac acc gag gat tac ggc aag tgg ttc ggc cag gcc atc gcc ggt gac       1344
Asn Thr Glu Asp Tyr Gly Lys Trp Phe Gly Gln Ala Ile Ala Gly Asp           
        435                 440                 445                       

aac gcc gtc ctg ggt ggc gac aag gac gag acc tgg gcc aag ttc gac       1392
Asn Ala Val Leu Gly Gly Asp Lys Asp Glu Thr Trp Ala Lys Phe Asp           
    450                 455                 460                           

ctg acc agc acc atc aac cgt gac agg aac gcc ccg tcc gtc atc atg       1440
Leu Thr Ser Thr Ile Asn Arg Asp Arg Asn Ala Pro Ser Val Ile Met           
465                 470                 475                 480           

tgg tcg ctc ggc aac gag atg atg gaa ggc atc agc ggc agc gtc tcg       1488
Trp Ser Leu Gly Asn Glu Met Met Glu Gly Ile Ser Gly Ser Val Ser           
                485                 490                 495               

ggc ttc ccg gct acc tcc gcc aag ctg gtc gca tgg acg aag gcc gcg       1536
Gly Phe Pro Ala Thr Ser Ala Lys Leu Val Ala Trp Thr Lys Ala Ala           
            500                 505                 510                   

gac agc acc cgc ccg atg acc tac ggc gac aac aag atc aag gcc aac       1584
Asp Ser Thr Arg Pro Met Thr Tyr Gly Asp Asn Lys Ile Lys Ala Asn           
        515                 520                 525                       

tgg aac gag tcg aac acc atg ggc gac aac ctg acc gcc aac ggc ggc       1632
Trp Asn Glu Ser Asn Thr Met Gly Asp Asn Leu Thr Ala Asn Gly Gly           
    530                 535                 540                           

gtg gtc ggc acc aac tac tcc gac ggc gcg aac tac gac aag atc cgc       1680
Val Val Gly Thr Asn Tyr Ser Asp Gly Ala Asn Tyr Asp Lys Ile Arg           
545                 550                 555                 560           

acg acc cac ccc tca tgg gcc atc tat ggt tcc gag acg gcg tcc gcc       1728
Thr Thr His Pro Ser Trp Ala Ile Tyr Gly Ser Glu Thr Ala Ser Ala           
                565                 570                 575               

atc aac agc cga ggc atc tac aac cgc acc acc ggc ggc gcc cag tca       1776
Ile Asn Ser Arg Gly Ile Tyr Asn Arg Thr Thr Gly Gly Ala Gln Ser           
            580                 585                 590                   

agc gac aag cag ctg acc agc tat gac aat tcc gca gtc ggc tgg ggc       1824
Ser Asp Lys Gln Leu Thr Ser Tyr Asp Asn Ser Ala Val Gly Trp Gly           
        595                 600                 605                       

gcc gtc gcc agc tcc gcc tgg tac gac gtg gtc cag cgc gat ttc gtc       1872
Ala Val Ala Ser Ser Ala Trp Tyr Asp Val Val Gln Arg Asp Phe Val           
    610                 615                 620                           

gcc ggc aca tac gtg tgg acc ggc ttc gac tac ctc ggc gaa ccc acc       1920
Ala Gly Thr Tyr Val Trp Thr Gly Phe Asp Tyr Leu Gly Glu Pro Thr           
625                 630                 635                 640           

ccg tgg aac ggc acc ggc tcc ggc gcc gtg ggc tcc tgg ccg tcg ccg       1968
Pro Trp Asn Gly Thr Gly Ser Gly Ala Val Gly Ser Trp Pro Ser Pro           
                645                 650                 655               

aag aac tcg tac ttc ggc atc gtc gac acc gca ggc ttc ccg aag gac       2016
Lys Asn Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Phe Pro Lys Asp           
            660                 665                 670                   

acc tat tac ttc tat cag agc cag tgg aac gac gac gtg cac acg ctg       2064
Thr Tyr Tyr Phe Tyr Gln Ser Gln Trp Asn Asp Asp Val His Thr Leu           
        675                 680                 685                       

cac atc ctc ccc gca tgg aac gag aac gtc gtc gcc aag ggc tcc ggc       2112
His Ile Leu Pro Ala Trp Asn Glu Asn Val Val Ala Lys Gly Ser Gly           
    690                 695                 700                           

aac aac gtg ccg gtc gtc gtc tac acc gac gcg gcc aag gtc aag ctg       2160
Asn Asn Val Pro Val Val Val Tyr Thr Asp Ala Ala Lys Val Lys Leu           
705                 710                 715                 720           

tac ttc aca ccg aag ggc agt acc gaa aag cga ctg atc gga gag aag       2208
Tyr Phe Thr Pro Lys Gly Ser Thr Glu Lys Arg Leu Ile Gly Glu Lys           
                725                 730                 735               

tcc ttc acc aag aag acc acc gcg gcc gga tac acc tat cag gtc tac       2256
Ser Phe Thr Lys Lys Thr Thr Ala Ala Gly Tyr Thr Tyr Gln Val Tyr           
            740                 745                 750                   

gag ggc tcc gac aag gac tcc acc gcc cac aag aac atg tac ctg acc       2304
Glu Gly Ser Asp Lys Asp Ser Thr Ala His Lys Asn Met Tyr Leu Thr           
        755                 760                 765                       

tgg aac gtg ccg tgg gcc gag ggc acc atc tcc gcc gaa gca tac gac       2352
Trp Asn Val Pro Trp Ala Glu Gly Thr Ile Ser Ala Glu Ala Tyr Asp           
    770                 775                 780                           

gag aac aac agg ctg atc ccc gag ggg tcc acc gag ggc aac gcg tcg       2400
Glu Asn Asn Arg Leu Ile Pro Glu Gly Ser Thr Glu Gly Asn Ala Ser           
785                 790                 795                 800           

gtg acc acc acc ggc aag gcc gcg aag ctt aaa gcc gat gcc gac cgc       2448
Val Thr Thr Thr Gly Lys Ala Ala Lys Leu Lys Ala Asp Ala Asp Arg           
                805                 810                 815               

aag acg atc acc gcg gac ggc aag gac ctg tcg tac atc gag gtc gac       2496
Lys Thr Ile Thr Ala Asp Gly Lys Asp Leu Ser Tyr Ile Glu Val Asp           
            820                 825                 830                   

gtg acc gac gcc aac ggc cat atc gtc ccc gat gcc gcc aac cgc gtc       2544
Val Thr Asp Ala Asn Gly His Ile Val Pro Asp Ala Ala Asn Arg Val           
        835                 840                 845                       

acc ttc gac gtc aag ggc gcc ggc aaa ctg gtc ggc gtc gac aac ggc       2592
Thr Phe Asp Val Lys Gly Ala Gly Lys Leu Val Gly Val Asp Asn Gly           
    850                 855                 860                           

agc tcg ccg gat cac gac tcc tat cag gcc gac aac cgc aag gcg ttc       2640
Ser Ser Pro Asp His Asp Ser Tyr Gln Ala Asp Asn Arg Lys Ala Phe           
865                 870                 875                 880           

agc ggc aag gtg ctc gcc atc gtc cag tcc acc aag gag gcg ggc gag       2688
Ser Gly Lys Val Leu Ala Ile Val Gln Ser Thr Lys Glu Ala Gly Glu           
                885                 890                 895               

atc acc gtc acc gcc aag gcc gac ggt ctg caa tca tcc aca gtg aag       2736
Ile Thr Val Thr Ala Lys Ala Asp Gly Leu Gln Ser Ser Thr Val Lys           
            900                 905                 910                   

atc gcc acc acc gcc gtc ccc ggc acc agc acc gag aag acg gtc cgc       2784
Ile Ala Thr Thr Ala Val Pro Gly Thr Ser Thr Glu Lys Thr Val Arg           
        915                 920                 925                       

agc ttc tac tac tcg cgc aac tac tac gtc aag acc ggc aac aag ccg       2832
Ser Phe Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys Thr Gly Asn Lys Pro           
    930                 935                 940                           

att ctg ccg agt gat gtc gag gtg cgc tac tcc gac ggc acg tcg gac       2880
Ile Leu Pro Ser Asp Val Glu Val Arg Tyr Ser Asp Gly Thr Ser Asp           
945                 950                 955                 960           

cgt cag aac gtc aca tgg gac gca gtc agc gac gac cag atc gcc aag       2928
Arg Gln Asn Val Thr Trp Asp Ala Val Ser Asp Asp Gln Ile Ala Lys           
                965                 970                 975               

gcc ggt tcg ttc agc gtg gcc ggc acg gtc gcc ggg cag aag atc tcc       2976
Ala Gly Ser Phe Ser Val Ala Gly Thr Val Ala Gly Gln Lys Ile Ser           
            980                 985                 990                   

gtg cgc gtg acg atg atc gac gag  atc ggt gcg ctg ctc  aac tat tcg     3024
Val Arg Val Thr Met Ile Asp Glu  Ile Gly Ala Leu Leu  Asn Tyr Ser         
        995                 1000                 1005                     

gcc agc  aca ccg gtc ggc acg  ccc gcc gtg ctg cct  ggc tcg cgt        3069
Ala Ser  Thr Pro Val Gly Thr  Pro Ala Val Leu Pro  Gly Ser Arg            
    1010                 1015                 1020                        

ccg gcc  gtg ctg ccc gac ggc  acc gtg acc agc gcg  aac ttc gcc        3114
Pro Ala  Val Leu Pro Asp Gly  Thr Val Thr Ser Ala  Asn Phe Ala            
    1025                 1030                 1035                        

gtc cac  tgg acc aag ccc gcc  gac acc gtg tac aac  acg gcc ggc        3159
Val His  Trp Thr Lys Pro Ala  Asp Thr Val Tyr Asn  Thr Ala Gly            
    1040                 1045                 1050                        

acc gtc  aag gtc ccc ggc acc  gcc acc gtc ttc ggc  aag gag ttc        3204
Thr Val  Lys Val Pro Gly Thr  Ala Thr Val Phe Gly  Lys Glu Phe            
    1055                 1060                 1065                        

aag gtc  acc gcg acg att cgc  gtg cag cgg tcg cag  gtc acc atc        3249
Lys Val  Thr Ala Thr Ile Arg  Val Gln Arg Ser Gln  Val Thr Ile            
    1070                 1075                 1080                        

ggc agc  agc gtc tcc ggc aat  gcg ctg cgc ctg act  cag aac atc        3294
Gly Ser  Ser Val Ser Gly Asn  Ala Leu Arg Leu Thr  Gln Asn Ile            
    1085                 1090                 1095                        

ccc gcc  gac aag cag tcc gac  acg ctg gac gcc atc  aag gac ggc        3339
Pro Ala  Asp Lys Gln Ser Asp  Thr Leu Asp Ala Ile  Lys Asp Gly            
    1100                 1105                 1110                        

tcc acg  acc gtc gac gcc aat  acc ggc ggc ggc gcg  aac ccg tca        3384
Ser Thr  Thr Val Asp Ala Asn  Thr Gly Gly Gly Ala  Asn Pro Ser            
    1115                 1120                 1125                        

gca tgg  acc aac tgg gcg tac  tcg aag gcc ggc cac  aac acc gcc        3429
Ala Trp  Thr Asn Trp Ala Tyr  Ser Lys Ala Gly His  Asn Thr Ala            
    1130                 1135                 1140                        

gag atc  acc ttc gag tac gcg  acc gag cag cag ctc  ggc cag att        3474
Glu Ile  Thr Phe Glu Tyr Ala  Thr Glu Gln Gln Leu  Gly Gln Ile            
    1145                 1150                 1155                        

gtc atg  tac ttc ttc cgc gac  agc aac gcg gtg agg  ttc ccc gac        3519
Val Met  Tyr Phe Phe Arg Asp  Ser Asn Ala Val Arg  Phe Pro Asp            
    1160                 1165                 1170                        

gcc ggc  aag acg aag atc cag  atc tcc gcg gac ggc  aag aac tgg        3564
Ala Gly  Lys Thr Lys Ile Gln  Ile Ser Ala Asp Gly  Lys Asn Trp            
    1175                 1180                 1185                        

acg gat  ctc gct gcc acg gag  acc atc gcg gcc cag  gag tcg tcc        3609
Thr Asp  Leu Ala Ala Thr Glu  Thr Ile Ala Ala Gln  Glu Ser Ser            
    1190                 1195                 1200                        

gac cga  gtc aag ccg tac acc  tat gac ttc gct ccg  gtg gga gcc        3654
Asp Arg  Val Lys Pro Tyr Thr  Tyr Asp Phe Ala Pro  Val Gly Ala            
    1205                 1210                 1215                        

acg ttc  gtc aag gtc acg gtc  acc aac gcc gac acc  aca acc ccc        3699
Thr Phe  Val Lys Val Thr Val  Thr Asn Ala Asp Thr  Thr Thr Pro            
    1220                 1225                 1230                        

agc ggc  gtg gtc tgc gcc ggc  ctg acc gag atc gag  ctg aag acc        3744
Ser Gly  Val Val Cys Ala Gly  Leu Thr Glu Ile Glu  Leu Lys Thr            
    1235                 1240                 1245                        

gcg acc  agc aag ttc gtc acg  aac acg tcc gcc gcg  ctc tcg tcg        3789
Ala Thr  Ser Lys Phe Val Thr  Asn Thr Ser Ala Ala  Leu Ser Ser            
    1250                 1255                 1260                        

ctg aca  gtg aac ggc acg aag  gtc tcc gac tcc gtg  ctc gcc gcc        3834
Leu Thr  Val Asn Gly Thr Lys  Val Ser Asp Ser Val  Leu Ala Ala            
    1265                 1270                 1275                        

ggc tcc  tac aac acg ccc gcg  atc atc gcg gac gtc  aaa gcc gag        3879
Gly Ser  Tyr Asn Thr Pro Ala  Ile Ile Ala Asp Val  Lys Ala Glu            
    1280                 1285                 1290                        

ggc gaa  ggc aac gcc agc gtc  acc gtg ctg ccc gcg  cac gac aac        3924
Gly Glu  Gly Asn Ala Ser Val  Thr Val Leu Pro Ala  His Asp Asn            
    1295                 1300                 1305                        

gtg atc  cgc gtg atc acc gag  tcc gag gac cac gtc  acg cgc aag        3969
Val Ile  Arg Val Ile Thr Glu  Ser Glu Asp His Val  Thr Arg Lys            
    1310                 1315                 1320                        

acc ttc  acc atc aac ctg ggc  acg gag cag gaa ttc  ccc gca gac        4014
Thr Phe  Thr Ile Asn Leu Gly  Thr Glu Gln Glu Phe  Pro Ala Asp            
    1325                 1330                 1335                        

tcc gat  gaa cgc gac tac ccg  gcc gcc gac atg acg  gtc acc gtg        4059
Ser Asp  Glu Arg Asp Tyr Pro  Ala Ala Asp Met Thr  Val Thr Val            
    1340                 1345                 1350                        

ggc agc  gaa cag acg tcc ggc  acc gcg acc gaa ggc  ccg aag aaa        4104
Gly Ser  Glu Gln Thr Ser Gly  Thr Ala Thr Glu Gly  Pro Lys Lys            
    1355                 1360                 1365                        

ttc gcg  gtc gac ggc aac acc  agc acg tac tgg cat  tcc aac tgg        4149
Phe Ala  Val Asp Gly Asn Thr  Ser Thr Tyr Trp His  Ser Asn Trp            
    1370                 1375                 1380                        

acg ccc  acc acc gtg aac gac  ctg tgg atc gcc ttc  gag ctc cag        4194
Thr Pro  Thr Thr Val Asn Asp  Leu Trp Ile Ala Phe  Glu Leu Gln            
    1385                 1390                 1395                        

aaa ccc  acc aag ctc gac gcg  ctg cgc tac ctg ccg  cgc ccc gcg        4239
Lys Pro  Thr Lys Leu Asp Ala  Leu Arg Tyr Leu Pro  Arg Pro Ala            
    1400                 1405                 1410                        

ggc agc  aag aac ggc tcc gtc  acc gaa tac aag gtt  cag gtc agc        4284
Gly Ser  Lys Asn Gly Ser Val  Thr Glu Tyr Lys Val  Gln Val Ser            
    1415                 1420                 1425                        

gat gac  ggc acc aac tgg acc  gac gcg ggc tcc ggc  aca tgg acc        4329
Asp Asp  Gly Thr Asn Trp Thr  Asp Ala Gly Ser Gly  Thr Trp Thr            
    1430                 1435                 1440                        

acc gat  tac ggc tgg aag ctc  gcc gag ttc aat cag  ccg gtg acc        4374
Thr Asp  Tyr Gly Trp Lys Leu  Ala Glu Phe Asn Gln  Pro Val Thr            
    1445                 1450                 1455                        

acc aag  cac gtg cgg ctc aag  gcc gtc cac acc tat  gcg gat tcc        4419
Thr Lys  His Val Arg Leu Lys  Ala Val His Thr Tyr  Ala Asp Ser            
    1460                 1465                 1470                        

ggc aac  gac aag ttc atg tcc  gcc tcc gaa atc cgc  ctg cgc aag        4464
Gly Asn  Asp Lys Phe Met Ser  Ala Ser Glu Ile Arg  Leu Arg Lys            
    1475                 1480                 1485                        

gcc gtc  gac acc acc gac atc  agc ggc gcg acc gtg  acc gtg ccc        4509
Ala Val  Asp Thr Thr Asp Ile  Ser Gly Ala Thr Val  Thr Val Pro            
    1490                 1495                 1500                        

gcc aag  ctg acc gtc gac cgg  gtg gac gcc gac cat  ccc gcc acc        4554
Ala Lys  Leu Thr Val Asp Arg  Val Asp Ala Asp His  Pro Ala Thr            
    1505                 1510                 1515                        

ttc gcc  acg aag gac gtg acg  gtg acg ttg ggc gac  gcc acg ctg        4599
Phe Ala  Thr Lys Asp Val Thr  Val Thr Leu Gly Asp  Ala Thr Leu            
    1520                 1525                 1530                        

cgc tac  ggc gtg gac tac ctg  ctc gac tac gcg ggc  aac acc gcc        4644
Arg Tyr  Gly Val Asp Tyr Leu  Leu Asp Tyr Ala Gly  Asn Thr Ala            
    1535                 1540                 1545                        

gtc ggc  aag gcc acg gtg acc  gtg cgc ggc atc gac  aag tac tcc        4689
Val Gly  Lys Ala Thr Val Thr  Val Arg Gly Ile Asp  Lys Tyr Ser            
    1550                 1555                 1560                        

ggc acc  gtc gcc aag acg ttc  acc atc gaa ctg aag  aac gcc ccg        4734
Gly Thr  Val Ala Lys Thr Phe  Thr Ile Glu Leu Lys  Asn Ala Pro            
    1565                 1570                 1575                        

gcg ccg  gaa ccg acg ctg acc  tcg gtg agc gtc aag  acc aag cct        4779
Ala Pro  Glu Pro Thr Leu Thr  Ser Val Ser Val Lys  Thr Lys Pro            
    1580                 1585                 1590                        

tcc aag  ctg acc tat gtg gtc  ggc gac gcg ttc gac  ccg gca gga        4824
Ser Lys  Leu Thr Tyr Val Val  Gly Asp Ala Phe Asp  Pro Ala Gly            
    1595                 1600                 1605                        

ctg gtg  ctg cag cac gac aga  cag gcc gat cgc ccc  cca cag cca        4869
Leu Val  Leu Gln His Asp Arg  Gln Ala Asp Arg Pro  Pro Gln Pro            
    1610                 1615                 1620                        

ctt gtt  gga gaa cag gcc gac  gaa cgc gga ctg acg  tgc gga acg        4914
Leu Val  Gly Glu Gln Ala Asp  Glu Arg Gly Leu Thr  Cys Gly Thr            
    1625                 1630                 1635                        

cga tgc  gat cgc gtt gaa cag  ctg cgc aaa cac gag  aat cgt gaa        4959
Arg Cys  Asp Arg Val Glu Gln  Leu Arg Lys His Glu  Asn Arg Glu            
    1640                 1645                 1650                        

gcc cat  cgt acg ggc ctc gat  cat ctg gaa ttc gtg  ggt gcc gcc        5004
Ala His  Arg Thr Gly Leu Asp  His Leu Glu Phe Val  Gly Ala Ala            
    1655                 1660                 1665                        

gat gga  gcg gtc ggt gaa cag  gcc acc ttc aag gtg  cat gtc cat        5049
Asp Gly  Ala Val Gly Glu Gln  Ala Thr Phe Lys Val  His Val His            
    1670                 1675                 1680                        

gcc gat  caa ggt gac ggc cgc  cat gat gat gcc gat  gaa cgc gat        5094
Ala Asp  Gln Gly Asp Gly Arg  His Asp Asp Ala Asp  Glu Arg Asp            
    1685                 1690                 1695                        

atc gat  cca cat gtc cct gtc  gat cac gcg gtc ggt  gag ctt gcg        5139
Ile Asp  Pro His Val Pro Val  Asp His Ala Val Gly  Glu Leu Ala            
    1700                 1705                 1710                        

cgg gct  gcg tgc cat cac gtc  atc ggt ctg cgg gtc  gac acc cat        5184
Arg Ala  Ala Cys His His Val  Ile Gly Leu Arg Val  Asp Thr His            
    1715                 1720                 1725                        

cgc ctc  aag gca tcc ggc ttc  cag atc ccc gcc gac  gac atg gcc        5229
Arg Leu  Lys Ala Ser Gly Phe  Gln Ile Pro Ala Asp  Asp Met Ala            
    1730                 1735                 1740                        

gag atc  gac cgc atc acc ggc  ttc cac cgc ttc gag  cgc cac gtc        5274
Glu Ile  Asp Arg Ile Thr Gly  Phe His Arg Phe Glu  Arg His Val            
    1745                 1750                 1755                        

ggc gtg  agc ggc tgg cgg ctg  ttc aag aag att agc  tga                5313
Gly Val  Ser Gly Trp Arg Leu  Phe Lys Lys Ile Ser                         
    1760                 1765                 1770                        


<210>  54
<211>  1770
<212>  PRT
<213>  synthetic

<400>  54

Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Val Glu Asp Ala Thr Arg Ser Asp Ser 
        35                  40                  45              


Thr Thr Gln Met Ser Ser Thr Pro Glu Val Val Tyr Ser Ser Ala Val 
    50                  55                  60                  


Asp Ser Lys Gln Asn Arg Thr Ser Asp Phe Asp Ala Asn Trp Lys Phe 
65                  70                  75                  80  


Met Leu Ser Asp Ser Val Gln Ala Gln Asp Pro Ala Phe Asp Asp Ser 
                85                  90                  95      


Ala Trp Gln Gln Val Asp Leu Pro His Asp Tyr Ser Ile Thr Gln Lys 
            100                 105                 110         


Tyr Ser Gln Ser Asn Glu Ala Glu Ser Ala Tyr Leu Pro Gly Gly Thr 
        115                 120                 125             


Gly Trp Tyr Arg Lys Ser Phe Thr Ile Asp Arg Asp Leu Ala Gly Lys 
    130                 135                 140                 


Arg Ile Ala Ile Asn Phe Asp Gly Val Tyr Met Asn Ala Thr Val Trp 
145                 150                 155                 160 


Phe Asn Gly Val Lys Leu Gly Thr His Pro Tyr Gly Tyr Ser Pro Phe 
                165                 170                 175     


Ser Phe Asp Leu Thr Gly Asn Ala Lys Phe Gly Gly Glu Asn Thr Ile 
            180                 185                 190         


Val Val Lys Val Glu Asn Arg Leu Pro Ser Ser Arg Trp Tyr Ser Gly 
        195                 200                 205             


Ser Gly Ile Tyr Arg Asp Val Thr Leu Thr Val Thr Asp Gly Val His 
    210                 215                 220                 


Val Gly Asn Asn Gly Val Ala Ile Lys Thr Pro Ser Leu Ala Thr Gln 
225                 230                 235                 240 


Asn Gly Gly Asp Val Thr Met Asn Leu Thr Thr Lys Val Ala Asn Asp 
                245                 250                 255     


Thr Glu Ala Ala Ala Asn Ile Thr Leu Lys Gln Thr Val Phe Pro Lys 
            260                 265                 270         


Gly Gly Lys Thr Asp Ala Ala Ile Gly Thr Val Thr Thr Ala Ser Lys 
        275                 280                 285             


Ser Ile Ala Ala Gly Ala Ser Ala Asp Val Thr Ser Thr Ile Thr Ala 
    290                 295                 300                 


Ala Ser Pro Lys Leu Trp Ser Ile Lys Asn Pro Asn Leu Tyr Thr Val 
305                 310                 315                 320 


Arg Thr Glu Val Leu Asn Gly Gly Lys Val Leu Asp Thr Tyr Asp Thr 
                325                 330                 335     


Glu Tyr Gly Phe Arg Trp Thr Gly Phe Asp Ala Thr Ser Gly Phe Ser 
            340                 345                 350         


Leu Asn Gly Glu Lys Val Lys Leu Lys Gly Val Ser Met His His Asp 
        355                 360                 365             


Gln Gly Ser Leu Gly Ala Val Ala Asn Arg Arg Ala Ile Glu Arg Gln 
    370                 375                 380                 


Val Glu Ile Leu Gln Lys Met Gly Val Asn Ser Ile Arg Thr Thr His 
385                 390                 395                 400 


Asn Pro Ala Ala Lys Ala Leu Ile Asp Val Cys Asn Glu Lys Gly Val 
                405                 410                 415     


Leu Val Val Glu Glu Val Phe Asp Met Trp Asn Arg Ser Lys Asn Gly 
            420                 425                 430         


Asn Thr Glu Asp Tyr Gly Lys Trp Phe Gly Gln Ala Ile Ala Gly Asp 
        435                 440                 445             


Asn Ala Val Leu Gly Gly Asp Lys Asp Glu Thr Trp Ala Lys Phe Asp 
    450                 455                 460                 


Leu Thr Ser Thr Ile Asn Arg Asp Arg Asn Ala Pro Ser Val Ile Met 
465                 470                 475                 480 


Trp Ser Leu Gly Asn Glu Met Met Glu Gly Ile Ser Gly Ser Val Ser 
                485                 490                 495     


Gly Phe Pro Ala Thr Ser Ala Lys Leu Val Ala Trp Thr Lys Ala Ala 
            500                 505                 510         


Asp Ser Thr Arg Pro Met Thr Tyr Gly Asp Asn Lys Ile Lys Ala Asn 
        515                 520                 525             


Trp Asn Glu Ser Asn Thr Met Gly Asp Asn Leu Thr Ala Asn Gly Gly 
    530                 535                 540                 


Val Val Gly Thr Asn Tyr Ser Asp Gly Ala Asn Tyr Asp Lys Ile Arg 
545                 550                 555                 560 


Thr Thr His Pro Ser Trp Ala Ile Tyr Gly Ser Glu Thr Ala Ser Ala 
                565                 570                 575     


Ile Asn Ser Arg Gly Ile Tyr Asn Arg Thr Thr Gly Gly Ala Gln Ser 
            580                 585                 590         


Ser Asp Lys Gln Leu Thr Ser Tyr Asp Asn Ser Ala Val Gly Trp Gly 
        595                 600                 605             


Ala Val Ala Ser Ser Ala Trp Tyr Asp Val Val Gln Arg Asp Phe Val 
    610                 615                 620                 


Ala Gly Thr Tyr Val Trp Thr Gly Phe Asp Tyr Leu Gly Glu Pro Thr 
625                 630                 635                 640 


Pro Trp Asn Gly Thr Gly Ser Gly Ala Val Gly Ser Trp Pro Ser Pro 
                645                 650                 655     


Lys Asn Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Phe Pro Lys Asp 
            660                 665                 670         


Thr Tyr Tyr Phe Tyr Gln Ser Gln Trp Asn Asp Asp Val His Thr Leu 
        675                 680                 685             


His Ile Leu Pro Ala Trp Asn Glu Asn Val Val Ala Lys Gly Ser Gly 
    690                 695                 700                 


Asn Asn Val Pro Val Val Val Tyr Thr Asp Ala Ala Lys Val Lys Leu 
705                 710                 715                 720 


Tyr Phe Thr Pro Lys Gly Ser Thr Glu Lys Arg Leu Ile Gly Glu Lys 
                725                 730                 735     


Ser Phe Thr Lys Lys Thr Thr Ala Ala Gly Tyr Thr Tyr Gln Val Tyr 
            740                 745                 750         


Glu Gly Ser Asp Lys Asp Ser Thr Ala His Lys Asn Met Tyr Leu Thr 
        755                 760                 765             


Trp Asn Val Pro Trp Ala Glu Gly Thr Ile Ser Ala Glu Ala Tyr Asp 
    770                 775                 780                 


Glu Asn Asn Arg Leu Ile Pro Glu Gly Ser Thr Glu Gly Asn Ala Ser 
785                 790                 795                 800 


Val Thr Thr Thr Gly Lys Ala Ala Lys Leu Lys Ala Asp Ala Asp Arg 
                805                 810                 815     


Lys Thr Ile Thr Ala Asp Gly Lys Asp Leu Ser Tyr Ile Glu Val Asp 
            820                 825                 830         


Val Thr Asp Ala Asn Gly His Ile Val Pro Asp Ala Ala Asn Arg Val 
        835                 840                 845             


Thr Phe Asp Val Lys Gly Ala Gly Lys Leu Val Gly Val Asp Asn Gly 
    850                 855                 860                 


Ser Ser Pro Asp His Asp Ser Tyr Gln Ala Asp Asn Arg Lys Ala Phe 
865                 870                 875                 880 


Ser Gly Lys Val Leu Ala Ile Val Gln Ser Thr Lys Glu Ala Gly Glu 
                885                 890                 895     


Ile Thr Val Thr Ala Lys Ala Asp Gly Leu Gln Ser Ser Thr Val Lys 
            900                 905                 910         


Ile Ala Thr Thr Ala Val Pro Gly Thr Ser Thr Glu Lys Thr Val Arg 
        915                 920                 925             


Ser Phe Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys Thr Gly Asn Lys Pro 
    930                 935                 940                 


Ile Leu Pro Ser Asp Val Glu Val Arg Tyr Ser Asp Gly Thr Ser Asp 
945                 950                 955                 960 


Arg Gln Asn Val Thr Trp Asp Ala Val Ser Asp Asp Gln Ile Ala Lys 
                965                 970                 975     


Ala Gly Ser Phe Ser Val Ala Gly Thr Val Ala Gly Gln Lys Ile Ser 
            980                 985                 990         


Val Arg Val Thr Met Ile Asp Glu  Ile Gly Ala Leu Leu  Asn Tyr Ser 
        995                 1000                 1005             


Ala Ser  Thr Pro Val Gly Thr  Pro Ala Val Leu Pro  Gly Ser Arg 
    1010                 1015                 1020             


Pro Ala  Val Leu Pro Asp Gly  Thr Val Thr Ser Ala  Asn Phe Ala 
    1025                 1030                 1035             


Val His  Trp Thr Lys Pro Ala  Asp Thr Val Tyr Asn  Thr Ala Gly 
    1040                 1045                 1050             


Thr Val  Lys Val Pro Gly Thr  Ala Thr Val Phe Gly  Lys Glu Phe 
    1055                 1060                 1065             


Lys Val  Thr Ala Thr Ile Arg  Val Gln Arg Ser Gln  Val Thr Ile 
    1070                 1075                 1080             


Gly Ser  Ser Val Ser Gly Asn  Ala Leu Arg Leu Thr  Gln Asn Ile 
    1085                 1090                 1095             


Pro Ala  Asp Lys Gln Ser Asp  Thr Leu Asp Ala Ile  Lys Asp Gly 
    1100                 1105                 1110             


Ser Thr  Thr Val Asp Ala Asn  Thr Gly Gly Gly Ala  Asn Pro Ser 
    1115                 1120                 1125             


Ala Trp  Thr Asn Trp Ala Tyr  Ser Lys Ala Gly His  Asn Thr Ala 
    1130                 1135                 1140             


Glu Ile  Thr Phe Glu Tyr Ala  Thr Glu Gln Gln Leu  Gly Gln Ile 
    1145                 1150                 1155             


Val Met  Tyr Phe Phe Arg Asp  Ser Asn Ala Val Arg  Phe Pro Asp 
    1160                 1165                 1170             


Ala Gly  Lys Thr Lys Ile Gln  Ile Ser Ala Asp Gly  Lys Asn Trp 
    1175                 1180                 1185             


Thr Asp  Leu Ala Ala Thr Glu  Thr Ile Ala Ala Gln  Glu Ser Ser 
    1190                 1195                 1200             


Asp Arg  Val Lys Pro Tyr Thr  Tyr Asp Phe Ala Pro  Val Gly Ala 
    1205                 1210                 1215             


Thr Phe  Val Lys Val Thr Val  Thr Asn Ala Asp Thr  Thr Thr Pro 
    1220                 1225                 1230             


Ser Gly  Val Val Cys Ala Gly  Leu Thr Glu Ile Glu  Leu Lys Thr 
    1235                 1240                 1245             


Ala Thr  Ser Lys Phe Val Thr  Asn Thr Ser Ala Ala  Leu Ser Ser 
    1250                 1255                 1260             


Leu Thr  Val Asn Gly Thr Lys  Val Ser Asp Ser Val  Leu Ala Ala 
    1265                 1270                 1275             


Gly Ser  Tyr Asn Thr Pro Ala  Ile Ile Ala Asp Val  Lys Ala Glu 
    1280                 1285                 1290             


Gly Glu  Gly Asn Ala Ser Val  Thr Val Leu Pro Ala  His Asp Asn 
    1295                 1300                 1305             


Val Ile  Arg Val Ile Thr Glu  Ser Glu Asp His Val  Thr Arg Lys 
    1310                 1315                 1320             


Thr Phe  Thr Ile Asn Leu Gly  Thr Glu Gln Glu Phe  Pro Ala Asp 
    1325                 1330                 1335             


Ser Asp  Glu Arg Asp Tyr Pro  Ala Ala Asp Met Thr  Val Thr Val 
    1340                 1345                 1350             


Gly Ser  Glu Gln Thr Ser Gly  Thr Ala Thr Glu Gly  Pro Lys Lys 
    1355                 1360                 1365             


Phe Ala  Val Asp Gly Asn Thr  Ser Thr Tyr Trp His  Ser Asn Trp 
    1370                 1375                 1380             


Thr Pro  Thr Thr Val Asn Asp  Leu Trp Ile Ala Phe  Glu Leu Gln 
    1385                 1390                 1395             


Lys Pro  Thr Lys Leu Asp Ala  Leu Arg Tyr Leu Pro  Arg Pro Ala 
    1400                 1405                 1410             


Gly Ser  Lys Asn Gly Ser Val  Thr Glu Tyr Lys Val  Gln Val Ser 
    1415                 1420                 1425             


Asp Asp  Gly Thr Asn Trp Thr  Asp Ala Gly Ser Gly  Thr Trp Thr 
    1430                 1435                 1440             


Thr Asp  Tyr Gly Trp Lys Leu  Ala Glu Phe Asn Gln  Pro Val Thr 
    1445                 1450                 1455             


Thr Lys  His Val Arg Leu Lys  Ala Val His Thr Tyr  Ala Asp Ser 
    1460                 1465                 1470             


Gly Asn  Asp Lys Phe Met Ser  Ala Ser Glu Ile Arg  Leu Arg Lys 
    1475                 1480                 1485             


Ala Val  Asp Thr Thr Asp Ile  Ser Gly Ala Thr Val  Thr Val Pro 
    1490                 1495                 1500             


Ala Lys  Leu Thr Val Asp Arg  Val Asp Ala Asp His  Pro Ala Thr 
    1505                 1510                 1515             


Phe Ala  Thr Lys Asp Val Thr  Val Thr Leu Gly Asp  Ala Thr Leu 
    1520                 1525                 1530             


Arg Tyr  Gly Val Asp Tyr Leu  Leu Asp Tyr Ala Gly  Asn Thr Ala 
    1535                 1540                 1545             


Val Gly  Lys Ala Thr Val Thr  Val Arg Gly Ile Asp  Lys Tyr Ser 
    1550                 1555                 1560             


Gly Thr  Val Ala Lys Thr Phe  Thr Ile Glu Leu Lys  Asn Ala Pro 
    1565                 1570                 1575             


Ala Pro  Glu Pro Thr Leu Thr  Ser Val Ser Val Lys  Thr Lys Pro 
    1580                 1585                 1590             


Ser Lys  Leu Thr Tyr Val Val  Gly Asp Ala Phe Asp  Pro Ala Gly 
    1595                 1600                 1605             


Leu Val  Leu Gln His Asp Arg  Gln Ala Asp Arg Pro  Pro Gln Pro 
    1610                 1615                 1620             


Leu Val  Gly Glu Gln Ala Asp  Glu Arg Gly Leu Thr  Cys Gly Thr 
    1625                 1630                 1635             


Arg Cys  Asp Arg Val Glu Gln  Leu Arg Lys His Glu  Asn Arg Glu 
    1640                 1645                 1650             


Ala His  Arg Thr Gly Leu Asp  His Leu Glu Phe Val  Gly Ala Ala 
    1655                 1660                 1665             


Asp Gly  Ala Val Gly Glu Gln  Ala Thr Phe Lys Val  His Val His 
    1670                 1675                 1680             


Ala Asp  Gln Gly Asp Gly Arg  His Asp Asp Ala Asp  Glu Arg Asp 
    1685                 1690                 1695             


Ile Asp  Pro His Val Pro Val  Asp His Ala Val Gly  Glu Leu Ala 
    1700                 1705                 1710             


Arg Ala  Ala Cys His His Val  Ile Gly Leu Arg Val  Asp Thr His 
    1715                 1720                 1725             


Arg Leu  Lys Ala Ser Gly Phe  Gln Ile Pro Ala Asp  Asp Met Ala 
    1730                 1735                 1740             


Glu Ile  Asp Arg Ile Thr Gly  Phe His Arg Phe Glu  Arg His Val 
    1745                 1750                 1755             


Gly Val  Ser Gly Trp Arg Leu  Phe Lys Lys Ile Ser  
    1760                 1765                 1770 


<210>  55
<211>  1677
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<222>  (1)..(1677)
<223>  glgA::KO

<400>  55
tgtgatctcc ggttcggtgg tggtgcagtc cgttctgttc tcgcgcgttc gcgtgaattc       60

attctgcaac attgattccg ccgtattgtt accggaagta tgggtaggtc gctcgtgccg      120

tctgcgccgc tgcgtcatcg atcgtgcttg tgttattccg gaaggcatgg tgattggtga      180

aaacgcagag gaagatgcac gtcgtttcta tcgttcagaa gaaggcatcg tgctggtaac      240

gcgcgaaatg ctacggaagt tagggcataa acaggagcga taaagcgatt ccatatgaat      300

atcctcctta gttcctattc cgaagttcct attctctaga aagtatagga acttcggcgc      360

gcctacctgt gacggaagat cacttcgcag aataaataaa tcctggtgtc cctgttgata      420

ccgggaagcc ctgggccaac ttttggcgaa aatgagacgt tgatcggcac gtaagaggtt      480

ccaactttca ccataatgaa ataagatcac taccgggcgt attttttgag ttgtcgagat      540

tttcaggagc taaggaagct aaaatggaga aaaaaatcac tggatatacc accgttgata      600

tatcccaatg gcatcgtaaa gaacattttg aggcatttca gtcagttgct caatgtacct      660

ataaccagac cgttcagctg gatattacgg cctttttaaa gaccgtaaag aaaaataagc      720

acaagtttta tccggccttt attcacattc ttgcccgcct gatgaatgct catccggaat      780

tacgtatggc aatgaaagac ggtgagctgg tgatatggga tagtgttcac ccttgttaca      840

ccgttttcca tgagcaaact gaaacgtttt catcgctctg gagtgaatac cacgacgatt      900

tccggcagtt tctacacata tattcgcaag atgtggcgtg ttacggtgaa aacctggcct      960

atttccctaa agggtttatt gagaatatgt ttttcgtctc agccaatccc tgggtgagtt     1020

tcaccagttt tgatttaaac gtggccaata tggacaactt cttcgccccc gttttcacca     1080

tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc gctggcgatt caggttcatc     1140

atgccgtttg tgatggcttc catgtcggca gaatgcttaa tgaattacaa cagtactgcg     1200

atgagtggca gggcggggcg taaggcgcgc catttaaatg aagttcctat tccgaagttc     1260

ctattctcta gaaagtatag gaacttcgaa gcagctccag ccattcatat gtttttcagg     1320

aaacgcctat atgaatgctc cgtttacata ttcatcgccc acgcttagcg tagaagctct     1380

taagcactct atcgcttaca agctgatgtt tacgattggc aaggatccgg tcgtcgccaa     1440

taaacatgaa tggctgaacg caacgttatt tgctgtgcgc gatcgtctcg tggagcgctg     1500

gttacgctca aaccgtgccc agttgtcgca agaaactcgt caggtttact acctgtcgat     1560

ggagtttttg attggccgta cgctttccaa cgccatgttg tcgctaggaa tttacgaaga     1620

tgtacagggc gcactggaag cgatgggatt aaatctcgaa gagctgattg atgaaga        1677


<210>  56
<211>  1899
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<222>  (1)..(1899)
<223>  nanA::KO

<400>  56
tgcggctgaa cacgccaccg atgagcaaat cgatttgctg gcaaaagcac tggaaatcaa       60

cagtcagtcg ctggataaca acgcggcatt cattcgctca gacgttgatt tccaccgcgt      120

tctggcggag atccctggta acccaatctt catggcgatc cacgttgccc tgctcgactg      180

gctaatcgcc gcacgtccaa ccgtggccga tcaggctctg catgagcata acaacgttag      240

ctatcaacag catattgcga tcgttgacgc gatccgccgt catgatcctg acgaagccga      300

tcgcgcgttg caatcgcatc tcaacagcgt ctctgctacc tggcacgcct tcggtcagac      360

caccaacaaa aagaaataat gccactttag tgaagcagat cgcattataa gctttctgta      420

tggggtgttg cttaattgat ctggtataac aggtataaag gtatatcgtt tatcagacaa      480

gcatcacttc agaggtattt agcgattcca tatgaatatc ctccttagtt cctattccga      540

agttcctatt ctctagaaag tataggaact tcggcgcgcc tacctgtgac ggaagatcac      600

ttcgcagaat aaataaatcc tggtgtccct gttgataccg ggaagccctg ggccaacttt      660

tggcgaaaat gagacgttga tcggcacgta agaggttcca actttcacca taatgaaata      720

agatcactac cgggcgtatt ttttgagttg tcgagatttt caggagctaa ggaagctaaa      780

atggagaaaa aaatcactgg atataccacc gttgatatat cccaatggca tcgtaaagaa      840

cattttgagg catttcagtc agttgctcaa tgtacctata accagaccgt tcagctggat      900

attacggcct ttttaaagac cgtaaagaaa aataagcaca agttttatcc ggcctttatt      960

cacattcttg cccgcctgat gaatgctcat ccggaattac gtatggcaat gaaagacggt     1020

gagctggtga tatgggatag tgttcaccct tgttacaccg ttttccatga gcaaactgaa     1080

acgttttcat cgctctggag tgaataccac gacgatttcc ggcagtttct acacatatat     1140

tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt tccctaaagg gtttattgag     1200

aatatgtttt tcgtctcagc caatccctgg gtgagtttca ccagttttga tttaaacgtg     1260

gccaatatgg acaacttctt cgcccccgtt ttcaccatgg gcaaatatta tacgcaaggc     1320

gacaaggtgc tgatgccgct ggcgattcag gttcatcatg ccgtttgtga tggcttccat     1380

gtcggcagaa tgcttaatga attacaacag tactgcgatg agtggcaggg cggggcgtaa     1440

ggcgcgccat ttaaatgaag ttcctattcc gaagttccta ttctctagaa agtataggaa     1500

cttcgaagca gctccagcca ttcatatgtg ttgtttcccc tcgctcgccc ctaccgggtg     1560

aggggaaata aacgcatctg taccctacaa ttttcatacc aaagcgtgtg ggcatcgccc     1620

accgcgggag actcacaatg agtactacaa cccagaatat cccgtggtat cgccatctta     1680

accgcgcaca atggcgggca ttttccgctg cctggttggg atatctgctt gacggttttg     1740

atttcgtttt aatcgccctg gtactcaccg aagtacaggg tgaattcggg ctcacgacgg     1800

tgcaggcggc aagtctgatc tccgcagcct ttatctctcg ctggttcggc ggcctgatgc     1860

tcggcgctat gggtgaccgc tacgggcgtc gtctggcaa                            1899


