                         SEQUENCE LISTING

<110>  NANJING LEGEND BIOTECH CO., LTD.
 
<120>  CD22 BINDING MOLECULES AND USES THEREOF

<130>  14651-027-228

<140>
<141>

<150>  PCT/CN2020/102465
<151>  2020-07-16

<160>  145   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR1 (Kabat)

<400>  1

Gly Gly Ser Phe Arg Ser Val Ser Met Gly 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR2 (Kabat)

<400>  2

Leu Leu Thr Ala Gly Met Arg Ser Asp Val Tyr Ala Asp Pro Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR3 (Kabat)

<400>  3

Gly Arg Arg Phe Arg Ser Asp His Trp Tyr Leu Asp Asp Tyr Glu Tyr 
1               5                   10                  15      


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR1 (IMGT)

<400>  4

Gly Gly Ser Phe Arg Ser Val Ser 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR2 (IMGT)

<400>  5

Leu Thr Ala Gly Met Arg Ser Asp 
1               5               


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR3 (IMGT)

<400>  6

Ala Ala Gly Arg Arg Phe Arg Ser Asp His Trp Tyr Leu Asp Asp Tyr 
1               5                   10                  15      


Glu Tyr 
        


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CDR1 (Kabat)

<400>  7

Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn 
1               5                   10          


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CDR2 (Kabat)

<400>  8

Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser 
1               5                   10                  15  


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CDR3 (Kabat)

<400>  9

Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn 
1               5                   10          


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CDR1 (IMGT)

<400>  10

Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr 
1               5                   10  


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CDR2 (IMGT)

<400>  11

Ile Ala Ala Ser Gly Ser Thr 
1               5           


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CDR3 (IMGT)

<400>  12

Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn 
1               5                   10                  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR1 (Kabat)

<400>  13

Val Tyr Thr Trp Gly Thr Tyr Cys Met Gly 
1               5                   10  


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR2 (Kabat)

<400>  14

Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr Ala Asn Ser Val Lys Gly 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR3 (Kabat)

<400>  15

Arg Ala Tyr Asp Ala Pro Trp Ala Cys Trp Thr Gly Ala Val Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR1 (IMGT)

<400>  16

Val Tyr Thr Trp Gly Thr Tyr Cys 
1               5               


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR2 (IMGT)

<400>  17

Ile Asp Pro Ala Gly Thr Thr 
1               5           


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR3 (IMGT)

<400>  18

Ala Ala Arg Ala Tyr Asp Ala Pro Trp Ala Cys Trp Thr Gly Ala Val 
1               5                   10                  15      


Phe Arg Asp 
            


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR1 (Kabat)

<400>  19

Gly Ser Met Tyr Ser Arg Tyr Cys Met Gly 
1               5                   10  


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR2 (Kabat)

<400>  20

Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr Ala Asn Ser Val Lys Gly 
1               5                   10                  15      


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR3 (Kabat)

<400>  21

Arg Ala Tyr Asp Ala Pro Trp Ser Cys Trp Thr Gly Ala Val Phe Gly 
1               5                   10                  15      


Asp 
    


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR1 (IMGT)

<400>  22

Gly Ser Met Tyr Ser Arg Tyr Cys 
1               5               


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR2 (IMGT)

<400>  23

Ile Asp Pro Ala Gly Thr Thr 
1               5           


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR3 (IMGT)

<400>  24

Ala Ala Arg Ala Tyr Asp Ala Pro Trp Ser Cys Trp Thr Gly Ala Val 
1               5                   10                  15      


Phe Gly Asp 
            


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR1 (Kabat)

<400>  25

Gly Tyr Thr Tyr Arg Gly Tyr Cys Leu Ala 
1               5                   10  


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR2 (Kabat)

<400>  26

Thr Ile Asp Ser Asp Gly Tyr Ile Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR3 (Kabat)

<400>  27

Arg Gly Gly Trp Cys Tyr Ser Leu Ser Lys Glu Tyr Asn Tyr 
1               5                   10                  


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR1 (IMGT)

<400>  28

Gly Tyr Thr Tyr Arg Gly Tyr Cys 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR2 (IMGT)

<400>  29

Ile Asp Ser Asp Gly Tyr Ile 
1               5           


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR3 (IMGT)

<400>  30

Ala Ala Arg Gly Gly Trp Cys Tyr Ser Leu Ser Lys Glu Tyr Asn Tyr 
1               5                   10                  15      


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR1 (Kabat)

<400>  31

Leu Ser Leu Asn Arg Val Ser Ile Ala 
1               5                   


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR2 (Kabat)

<400>  32

Thr Gln Ser Phe Thr Gly Asp Thr Ala Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR3 (Kabat)

<400>  33

Gly Arg Thr Tyr Ser Ser Arg Asp Pro Leu Ala Asp Glu Tyr Asn Tyr 
1               5                   10                  15      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR1 (IMGT)

<400>  34

Leu Ser Leu Asn Arg Val Ser 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR2 (IMGT)

<400>  35

Gln Ser Phe Thr Gly Asp Thr 
1               5           


<210>  36
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR3 (IMGT)

<400>  36

Ala Ala Gly Arg Thr Tyr Ser Ser Arg Asp Pro Leu Ala Asp Glu Tyr 
1               5                   10                  15      


Asn Tyr 
        


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1160 CDR1 (Kabat)

<400>  37

Thr Arg Ile Phe Arg Ser Tyr Asn Met Ala 
1               5                   10  


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1160 CDR2 (Kabat)

<400>  38

Ala Ile Arg Ser Gly Glu Pro Leu Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1160 CDR3 (Kabat)

<400>  39

Asp Ser Pro Pro Trp Ala Gly Ser Tyr Ser Gly Pro Tyr Asp Tyr 
1               5                   10                  15  


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1160 CDR1 (IMGT)

<400>  40

Thr Arg Ile Phe Arg Ser Tyr Asn 
1               5               


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1160 CDR2 (IMGT)

<400>  41

Ile Arg Ser Gly Glu Pro Leu 
1               5           


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1160 CDR3 (IMGT)

<400>  42

Ala Ala Asp Ser Pro Pro Trp Ala Gly Ser Tyr Ser Gly Pro Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1161 CDR1 (Kabat)

<400>  43

Thr Arg Ile Phe Arg Ser Tyr Asn Met Ala 
1               5                   10  


<210>  44
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1161 CDR2 (Kabat)

<400>  44

Ala Ile Arg Ser Gly Ser Ile Thr Asp Ser Thr Tyr Tyr Ser Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1161 CDR3 (Kabat)

<400>  45

Asp Ser Pro Pro Trp Ser Gly Asn Tyr Ser Gly Pro Tyr Asp Tyr 
1               5                   10                  15  


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1161 CDR1 (IMGT)

<400>  46

Thr Arg Ile Phe Arg Ser Tyr Asn 
1               5               


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1161 CDR2 (IMGT)

<400>  47

Ile Arg Ser Gly Ser Ile Thr Asp Ser Thr 
1               5                   10  


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1161 CDR3 (IMGT)

<400>  48

Ala Ala Asp Ser Pro Pro Trp Ser Gly Asn Tyr Ser Gly Pro Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1162 CDR1 (Kabat)

<400>  49

Thr Arg Ile Phe Arg Ser Tyr Asn Met Ala 
1               5                   10  


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1162 CDR2 (Kabat)

<400>  50

Gly Ile Arg Gly Gly Gly Ala Thr Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1162 CDR3 (Kabat)

<400>  51

Asp Ser Pro Pro Trp Ser Gly Ser Ser Ser Gly Pro Tyr Asp Tyr 
1               5                   10                  15  


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1162 CDR1 (IMGT)

<400>  52

Thr Arg Ile Phe Arg Ser Tyr Asn 
1               5               


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1162 CDR2 (IMGT)

<400>  53

Ile Arg Gly Gly Gly Ala Thr 
1               5           


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1162 CDR3 (IMGT)

<400>  54

Ala Ala Asp Ser Pro Pro Trp Ser Gly Ser Ser Ser Gly Pro Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1163 CDR1 (Kabat)

<400>  55

Thr Arg Ile Phe Arg Ser Tyr Asn Met Ala 
1               5                   10  


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1163 CDR2 (Kabat)

<400>  56

Gly Met Arg Ser Gly Glu Pro Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1163 CDR3 (Kabat)

<400>  57

Asp Ser Pro Pro Trp Ser Gly Ser Tyr Ser Gly Pro Tyr Asp Tyr 
1               5                   10                  15  


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1163 CDR1 (IMGT)

<400>  58

Thr Arg Ile Phe Arg Ser Tyr Asn 
1               5               


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1163 CDR2 (IMGT)

<400>  59

Met Arg Ser Gly Glu Pro Thr 
1               5           


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1163 CDR3 (IMGT)

<400>  60

Ala Ala Asp Ser Pro Pro Trp Ser Gly Ser Tyr Ser Gly Pro Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1164 CDR1 (Kabat)

<400>  61

Thr Arg Ile Phe Arg Ser Tyr Asp Met Ala 
1               5                   10  


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1164 CDR2 (Kabat)

<400>  62

Ala Ser Arg Ala Gly Gly Pro Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1164 CDR3 (Kabat)

<400>  63

Asp Ser Pro Pro Trp Ser Gly Ser Tyr Ser Gly Pro Tyr Asp Tyr 
1               5                   10                  15  


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1164 CDR1 (IMGT)

<400>  64

Thr Arg Ile Phe Arg Ser Tyr Asp 
1               5               


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1164 CDR2 (IMGT)

<400>  65

Ser Arg Ala Gly Gly Pro Thr 
1               5           


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1164 CDR3 (IMGT)

<400>  66

Ala Ala Asp Ser Pro Pro Trp Ser Gly Ser Tyr Ser Gly Pro Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2201H2 CDR3 (IMGT)

<400>  67

Ala Lys Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn 
1               5                   10                  


<210>  68
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2201H3 CDR3 (IMGT)

<400>  68

Ala Ala Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn 
1               5                   10                  


<210>  69
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 (amino acid)

<400>  69

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Glu Ile Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Lys Tyr Ser Gly Gly Ser Phe Arg Ser Val 
            20                  25                  30          


Ser Met Gly Trp Leu Arg Gln Ala Val Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Leu Leu Thr Ala Gly Met Arg Ser Asp Val Tyr Ala Asp Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Ile Asp Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Asp Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Arg Phe Arg Ser Asp His Trp Tyr Leu Asp Asp Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  70
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 (amino acid)

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  71
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 (amino acid)

<400>  71

Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Val Tyr Thr Trp Gly Thr Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr Ala Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Asp Asp Asn Ala Gln Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Ala Tyr Asp Ala Pro Trp Ala Cys Trp Thr Gly Ala Val Phe 
            100                 105                 110         


Arg Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  72
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 (amino acid)

<400>  72

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Met Tyr Ser Arg Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr Ala Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Gln Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Ala Tyr Asp Ala Pro Trp Ser Cys Trp Thr Gly Ala Val Phe 
            100                 105                 110         


Gly Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  73
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 (amino acid)

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Arg Gly Tyr 
            20                  25                  30          


Cys Leu Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Thr Ile Asp Ser Asp Gly Tyr Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Thr Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Gly Gly Trp Cys Tyr Ser Leu Ser Lys Glu Tyr Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  74
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 (amino acid)

<400>  74

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Glu Ser Leu Ser Leu Asn Arg Val Ser 
            20                  25                  30          


Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
        35                  40                  45              


Thr Gln Ser Phe Thr Gly Asp Thr Ala Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr Leu Ser 
65                  70                  75                  80  


Met Asn Ser Leu Lys Leu Glu Asp Ser Ala Lys Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Gly Arg Thr Tyr Ser Ser Arg Asp Pro Leu Ala Asp Glu Tyr Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  75
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1160 (amino acid)

<400>  75

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Thr Arg Ile Phe Arg Ser Tyr 
            20                  25                  30          


Asn Met Ala Trp Phe Arg Gln Val Val Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Ser Gly Glu Pro Leu Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Ser Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Ser Pro Pro Trp Ala Gly Ser Tyr Ser Gly Pro Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  76
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1161 (amino acid)

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Arg Ile Phe Arg Ser Tyr 
            20                  25                  30          


Asn Met Ala Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Ser Gly Ser Ile Thr Asp Ser Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Ser Pro Pro Trp Ser Gly Asn Tyr Ser Gly Pro 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  77
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1162 (amino acid)

<400>  77

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Thr Arg Ile Phe Arg Ser Tyr 
            20                  25                  30          


Asn Met Ala Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Arg Gly Gly Gly Ala Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Ser Pro Pro Trp Ser Gly Ser Ser Ser Gly Pro Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  78
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1163 (amino acid)

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Thr Arg Ile Phe Arg Ser Tyr 
            20                  25                  30          


Asn Met Ala Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Gly Met Arg Ser Gly Glu Pro Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Ser Pro Pro Trp Ser Gly Ser Tyr Ser Gly Pro Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  79
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1164 (amino acid)

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Arg Ile Phe Arg Ser Tyr 
            20                  25                  30          


Asp Met Ala Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ser Arg Ala Gly Gly Pro Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Ser Pro Pro Trp Ser Gly Ser Tyr Ser Gly Pro Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  80
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-077 (amino acid)

<400>  80

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  81
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2201H1 (amino acid)

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Ser Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  82
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2201H2 (amino acid)

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Phe Tyr Trp Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Glu Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2201H3 (amino acid)

<400>  83

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ala Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Phe Tyr Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Glu Ser Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  84
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2201H4 (amino acid)

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Phe Tyr Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  85
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-18 (nucleic acid)

<400>  85
caggttaagc tggtggagag cggaggcggc tccgtggaga tcggtggctc cctacgcctg       60

gcctgcaagt actccggtgg ttccttccgc tcggtatcta tgggctggct ccgccaggcc      120

gtggggaagg agcgcgaggg cgtcgctctg cttactgctg gaatgcgtag cgacgtgtac      180

gcggacccgg tgaagggccg cttcaccatc tcacaggata ttgacaaaaa cacgatgtac      240

ctggacatga acgcgctgaa gcccgaagac accgccatgt attactgtgc cgcagggcga      300

aggtttcgga gtgaccactg gtacttggat gactacgagt attggggcca gggcacccag      360

gtcaccgtga gctct                                                       375


<210>  86
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-66 (nucleic acid)

<400>  86
gaggtgcagc tggtggagag tgggcccggg ttggtgaagc cctctcagac tctgtctctg       60

acctgcaccg tgtccggtgc ttccatcacc accggcgagt tctattggaa ttggttccgc      120

cagccgcctg gcaagggcct ggagtggatg ggcgccatcg cggcttctgg ctccacgacc      180

tactccccat ccttcgagag ccgcaccagc atctctcgcg acacctccga gaaccagttc      240

tacctgcagc tgagctccgt gactccggaa gataccgccg tgtactactg cgggcgcagc      300

ttcggcgtgg cggccgtcac cacaggccag aaccgcggac agggcaccca ggtcaccgtg      360

tcgtcc                                                                 366


<210>  87
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-87 (nucleic acid)

<400>  87
caaatccagc tggtggagag tggtggtgga tcggtgcaga gcggaggctc cctccgcctg       60

tcatgcaagg cctccgtgta cacctggggc acctactgta tgggctggtt ccgccaggcc      120

cccgggaagg agcgcgaggg cgtcgcaact attgacccag ctgggaccac aacttacgcc      180

aactccgtta agggccgctt caccatcagc gatgacaacg cgcagaacac gctgtacctg      240

cagatgaact ccttgaggcc tgaagacacc gccatgtatt actgtgctgc gcgggcctac      300

gacgctccgt gggcgtgctg gacgggtgcc gtgtttcgtg attggggcca gggcacccag      360

gtcaccgtgt cctct                                                       375


<210>  88
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-90 (nucleic acid)

<400>  88
caagtgcagc tggtggagag cggaggcggc tccgtgcaga gcggtggcag tctcaagctg       60

agctgcgccg cttccggttc tatgtactcc cgctactgca tgggctggtt ccgccaggcc      120

cccgggaagg agagggaggg cgtcgcaact attgaccctg ctggaacaac cacctacgcg      180

aactccgtta aaggccgctt caccatctct ggggacaacg cgcagaacac gatgtacctg      240

cagatgaact ccttgcggcc cgaagacacc gccatgtatt actgtgctgc tcgtgcctac      300

gacgccccgt ggtcttgttg gactggggcg gtgtttggtg attggggcca gggcacccag      360

gtcaccgtgt cgtcg                                                       375


<210>  89
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-102 (nucleic acid)

<400>  89
gaggtgcagc tggtggagag cggaggtggg tctgtgcaaa gcggcggctc cctccgcctg       60

tcatgcgccg cttccggata cacctacagg ggctactgcc tggcgtggtt ccgccaggcc      120

cccgggaaag agcgcgagcg ggtcgccact attgacagcg atggctacat ctcgtacgcg      180

gactccgtga agggccgctt taccatctct caggacaaca ctaagaacac gttgtacctg      240

gagatgaata cactgaagcc tgaagacacc gccatgtatt actgtgctgc acgtggtggt      300

tggtgttact ccctttccaa ggagtacaac tattggggcc agggcaccca ggtcaccgtt      360

tcgagt                                                                 366


<210>  90
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-105 (nucleic acid)

<400>  90
caagtgcagc tggtggagag cggaggcggc tccgtgcagg ccggtggttc tcttcgattg       60

tcatgcgccg aaagtctatc tctcaaccgc gtcagcattg catggttccg ccaggctcct      120

ggcaaggaga gggagggcgt agctacccag agctttacag gggacaccgc gtacgcggat      180

tctgttaaag ggcgcttcac catctcccgc gacaacacta agaacacggt gtacctgtcc      240

atgaactccc tgaagctgga ggacagcgcc aagtactact gtgccgctgg acgtacttac      300

tcctcccggg atcccctggc ggacgagtac aactattggg gccagggcac ccaggtcacc      360

gtgtcgtcg                                                              369


<210>  91
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-077 (nucleic acid)

<400>  91
caggtgcagc tgcaggagag tgggcccggg ttggtgaagc cctctcagac tctttctctg       60

acctgcaccg tgtccggtgc ttccatcacc accggcgagt tctattggaa ttggttccgc      120

cagccgcccg gcaagggcct ggagtggatg ggcgccatcg cggcttctgg ctccacgacc      180

tactccccat ccttcgagag ccgcaccagc atctcccgcg acacctccaa gaaccagttt      240

tcactgaagc tgagctccgt gacggccgcg gacaccgccg tgtactactg cgggcgctcc      300

ttcggcgtgg cggccgtcac cacaggccag aaccgcggac agggcaccct ggtgaccgtg      360

agctcg                                                                 366


<210>  92
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CAR (amino acid)

<400>  92

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Glu Ile Gly Gly Ser Leu Arg Leu Ala Cys Lys Tyr Ser Gly Gly 
        35                  40                  45              


Ser Phe Arg Ser Val Ser Met Gly Trp Leu Arg Gln Ala Val Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Leu Leu Thr Ala Gly Met Arg Ser Asp Val 
65                  70                  75                  80  


Tyr Ala Asp Pro Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Ile Asp 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Asp Met Asn Ala Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Gly Arg Arg Phe Arg Ser Asp His Trp 
        115                 120                 125             


Tyr Leu Asp Asp Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
145                 150                 155                 160 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
                165                 170                 175     


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
            180                 185                 190         


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        195                 200                 205             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
    210                 215                 220                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
225                 230                 235                 240 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                245                 250                 255     


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            260                 265                 270         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        275                 280                 285             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    290                 295                 300                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
305                 310                 315                 320 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                325                 330                 335     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            340                 345                 350         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        355                 360                 365             


Pro Pro Arg 
    370     


<210>  93
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CAR (amino acid)

<400>  93

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  94
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CAR (amino acid)

<400>  94

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ser Gly Gly Ser Leu Arg Leu Ser Cys Lys Ala Ser Val Tyr 
        35                  40                  45              


Thr Trp Gly Thr Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr 
65                  70                  75                  80  


Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Asp Asp Asn Ala Gln 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Arg Ala Tyr Asp Ala Pro Trp Ala Cys Trp 
        115                 120                 125             


Thr Gly Ala Val Phe Arg Asp Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
145                 150                 155                 160 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
                165                 170                 175     


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
            180                 185                 190         


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        195                 200                 205             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
    210                 215                 220                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
225                 230                 235                 240 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                245                 250                 255     


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            260                 265                 270         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        275                 280                 285             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    290                 295                 300                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
305                 310                 315                 320 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                325                 330                 335     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            340                 345                 350         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        355                 360                 365             


Pro Pro Arg 
    370     


<210>  95
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CAR (amino acid)

<400>  95

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ser Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser 
        35                  40                  45              


Met Tyr Ser Arg Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr 
65                  70                  75                  80  


Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Gln 
                85                  90                  95      


Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Arg Ala Tyr Asp Ala Pro Trp Ser Cys Trp 
        115                 120                 125             


Thr Gly Ala Val Phe Gly Asp Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
145                 150                 155                 160 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
                165                 170                 175     


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
            180                 185                 190         


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        195                 200                 205             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
    210                 215                 220                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
225                 230                 235                 240 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                245                 250                 255     


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            260                 265                 270         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        275                 280                 285             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    290                 295                 300                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
305                 310                 315                 320 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                325                 330                 335     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            340                 345                 350         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        355                 360                 365             


Pro Pro Arg 
    370     


<210>  96
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CAR (amino acid)

<400>  96

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ser Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Thr Tyr Arg Gly Tyr Cys Leu Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Arg Val Ala Thr Ile Asp Ser Asp Gly Tyr Ile Ser Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Thr Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Glu Met Asn Thr Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Ala Arg Gly Gly Trp Cys Tyr Ser Leu Ser Lys 
        115                 120                 125             


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  97
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CAR (amino acid)

<400>  97

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Glu Ser Leu Ser 
        35                  40                  45              


Leu Asn Arg Val Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Gly Val Ala Thr Gln Ser Phe Thr Gly Asp Thr Ala Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Ser Met Asn Ser Leu Lys Leu Glu Asp Ser Ala Lys 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Arg Thr Tyr Ser Ser Arg Asp Pro Leu Ala 
        115                 120                 125             


Asp Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  98
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-077  CAR (amino acid)

<400>  98

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  99
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m971 scFv CAR (amino acid)

<400>  99

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
65                  70                  75                  80  


Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu 
        115                 120                 125             


Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        195                 200                 205             


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  100
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-18 CAR (nucleic acid)

<400>  100
atggcgttgc cggtcactgc tctactgctg cccctggctc tgctccttca cgccgccagg       60

cctcaggtta agctggtgga gagcggaggc ggctccgtgg agatcggtgg ctccctacgc      120

ctggcctgca agtactccgg tggttccttc cgctcggtat ctatgggctg gctccgccag      180

gccgtgggga aggagcgcga gggcgtcgct ctgcttactg ctggaatgcg tagcgacgtg      240

tacgcggacc cggtgaaggg ccgcttcacc atctcacagg atattgacaa aaacacgatg      300

tacctggaca tgaacgcgct gaagcccgaa gacaccgcca tgtattactg tgccgcaggg      360

cgaaggtttc ggagtgacca ctggtacttg gatgactacg agtattgggg ccagggcacc      420

caggtcaccg tgagctctac tagtaccacg acgccagcgc cgcgaccacc aacaccggcg      480

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      540

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg      600

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc      660

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa      720

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga      780

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat      840

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      900

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa      960

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1020

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1080

gacgcccttc acatgcaggc cctgccccct cgctaa                               1116


<210>  101
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-66 CAR (nucleic acid)

<400>  101
atggcgttgc cggtcactgc tctactgctg cccctggctc tgctccttca cgccgccagg       60

cctgaggtgc agctggtgga gagtgggccc gggttggtga agccctctca gactctgtct      120

ctgacctgca ccgtgtccgg tgcttccatc accaccggcg agttctattg gaattggttc      180

cgccagccgc ctggcaaggg cctggagtgg atgggcgcca tcgcggcttc tggctccacg      240

acctactccc catccttcga gagccgcacc agcatctctc gcgacacctc cgagaaccag      300

ttctacctgc agctgagctc cgtgactccg gaagataccg ccgtgtacta ctgcgggcgc      360

agcttcggcg tggcggccgt caccacaggc cagaaccgcg gacagggcac ccaggtcacc      420

gtgtcgtcca ctagtaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      480

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      540

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      600

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa      660

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      720

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc      780

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      840

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      900

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      960

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1020

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1080

cacatgcagg ccctgccccc tcgctaa                                         1107


<210>  102
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-87 CAR (nucleic acid)

<400>  102
atggcgttgc cggtcactgc tctactgctg cccctggctc tgctccttca cgccgccagg       60

cctcaaatcc agctggtgga gagtggtggt ggatcggtgc agagcggagg ctccctccgc      120

ctgtcatgca aggcctccgt gtacacctgg ggcacctact gtatgggctg gttccgccag      180

gcccccggga aggagcgcga gggcgtcgca actattgacc cagctgggac cacaacttac      240

gccaactccg ttaagggccg cttcaccatc agcgatgaca acgcgcagaa cacgctgtac      300

ctgcagatga actccttgag gcctgaagac accgccatgt attactgtgc tgcgcgggcc      360

tacgacgctc cgtgggcgtg ctggacgggt gccgtgtttc gtgattgggg ccagggcacc      420

caggtcaccg tgtcctctac tagtaccacg acgccagcgc cgcgaccacc aacaccggcg      480

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      540

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg      600

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc      660

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa      720

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga      780

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat      840

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      900

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa      960

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1020

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1080

gacgcccttc acatgcaggc cctgccccct cgctaa                               1116


<210>  103
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-90 CAR (nucleic acid)

<400>  103
atggcgttgc cggtcactgc tctactgctg cccctggctc tgctccttca cgccgccagg       60

cctcaagtgc agctggtgga gagcggaggc ggctccgtgc agagcggtgg cagtctcaag      120

ctgagctgcg ccgcttccgg ttctatgtac tcccgctact gcatgggctg gttccgccag      180

gcccccggga aggagaggga gggcgtcgca actattgacc ctgctggaac aaccacctac      240

gcgaactccg ttaaaggccg cttcaccatc tctggggaca acgcgcagaa cacgatgtac      300

ctgcagatga actccttgcg gcccgaagac accgccatgt attactgtgc tgctcgtgcc      360

tacgacgccc cgtggtcttg ttggactggg gcggtgtttg gtgattgggg ccagggcacc      420

caggtcaccg tgtcgtcgac tagtaccacg acgccagcgc cgcgaccacc aacaccggcg      480

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      540

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg      600

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc      660

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa      720

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga      780

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat      840

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      900

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa      960

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1020

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1080

gacgcccttc acatgcaggc cctgccccct cgctaa                               1116


<210>  104
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-102 CAR (nucleic acid)

<400>  104
atggcgttgc cggtcactgc tctactgctg cccctggctc tgctccttca cgccgccagg       60

cctgaggtgc agctggtgga gagcggaggt gggtctgtgc aaagcggcgg ctccctccgc      120

ctgtcatgcg ccgcttccgg atacacctac aggggctact gcctggcgtg gttccgccag      180

gcccccggga aagagcgcga gcgggtcgcc actattgaca gcgatggcta catctcgtac      240

gcggactccg tgaagggccg ctttaccatc tctcaggaca acactaagaa cacgttgtac      300

ctggagatga atacactgaa gcctgaagac accgccatgt attactgtgc tgcacgtggt      360

ggttggtgtt actccctttc caaggagtac aactattggg gccagggcac ccaggtcacc      420

gtttcgagta ctagtaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      480

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      540

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      600

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa      660

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      720

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc      780

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      840

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      900

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      960

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1020

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1080

cacatgcagg ccctgccccc tcgctaa                                         1107


<210>  105
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-105 CAR (nucleic acid)

<400>  105
atggcgttgc cggtcactgc tctactgctg cccctggctc tgctccttca cgccgccagg       60

cctcaagtgc agctggtgga gagcggaggc ggctccgtgc aggccggtgg ttctcttcga      120

ttgtcatgcg ccgaaagtct atctctcaac cgcgtcagca ttgcatggtt ccgccaggct      180

cctggcaagg agagggaggg cgtagctacc cagagcttta caggggacac cgcgtacgcg      240

gattctgtta aagggcgctt caccatctcc cgcgacaaca ctaagaacac ggtgtacctg      300

tccatgaact ccctgaagct ggaggacagc gccaagtact actgtgccgc tggacgtact      360

tactcctccc gggatcccct ggcggacgag tacaactatt ggggccaggg cacccaggtc      420

accgtgtcgt cgactagtac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      480

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      540

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg      600

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag      660

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      720

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag      780

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      840

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      900

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag      960

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1020

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1080

cttcacatgc aggccctgcc ccctcgctaa                                      1110


<210>  106
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-077 CAR (nucleic acid)

<400>  106
atggcgctgc cggtgactgc tctgctgctg cccctggcct tgctgctcca cgccgccagg       60

cctcaggtgc agctgcagga gagtgggccc gggttggtga agccctctca gactctttct      120

ctgacctgca ccgtgtccgg tgcttccatc accaccggcg agttctattg gaattggttc      180

cgccagccgc ccggcaaggg cctggagtgg atgggcgcca tcgcggcttc tggctccacg      240

acctactccc catccttcga gagccgcacc agcatctccc gcgacacctc caagaaccag      300

ttttcactga agctgagctc cgtgacggcc gcggacaccg ccgtgtacta ctgcgggcgc      360

tccttcggcg tggcggccgt caccacaggc cagaaccgcg gacagggcac cctggtgacc      420

gtgagctcga ctagtaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      480

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      540

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      600

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa      660

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      720

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc      780

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      840

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      900

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      960

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1020

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1080

cacatgcagg ccctgccccc tcgctaa                                         1107


<210>  107
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m971 scFv CAR (nucleic acid)

<400>  107
atggcccttc cggtgactgc cctcttgctg cccctggcgc tgctgctgca cgccgctcgt       60

cctcaggtgc agctgcaaca gtccggtccc gggctggtga agccctcaca gactctctcc      120

cttacgtgtg ccatctccgg cgattctgtt agctcgaaca gcgcagcctg gaattggatc      180

cgccagagcc cttcgagagg cctggaatgg ctaggccgca cctactaccg ctcgaaatgg      240

tacaacgact atgccgtgtc cgtcaaaagc cgcatcacta ttaatccaga tacatccaag      300

aaccagttct ccctccagct taactccgta acccccgagg acaccgccgt gtactattgt      360

gctcgcgagg tgaccggcga cctggaggat gccttcgaca tctggggcca gggaacaatg      420

gtgaccgtct catctggtgg cggcggctcc ggcggtgggg gctccggcgg tggtggctcc      480

gacatccaga tgacccagag cccatcgtcg ttgtccgcct ccgtgggaga cagggtcacg      540

atcacctgcc gagcctccca gaccatatgg tcttacctga actggtacca gcagcgcccg      600

ggcaaggctc ccaacctgct gatttacgcg gcgagttctc tgcagagcgg tgtcccgagt      660

cgtttttcag ggcgggggtc tggcaccgac ttcaccctga ccatctcttc cttgcaggcc      720

gaggactttg caacttacta ttgccaacag agctactcca tccctcagac cttcggacag      780

gggaccaagc tggagattaa gactagtacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                            1479


<210>  108
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 1


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  can be repeated n times, where n is an integer including, e.g., 
       1, 2, 3, 4, 5, and 6

<400>  108

Gly Ser 
1       


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 2


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  can be repeated n times, where n is an integer including, e.g., 
       1, 2, 3, 4, 5, and 6

<400>  109

Gly Ser Gly Gly Ser 
1               5   


<210>  110
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 3


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  can be repeated n times, where n is an integer including, e.g., 
       1, 2, 3, 4, 5, and 6

<400>  110

Gly Gly Gly Ser 
1               


<210>  111
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 4

<400>  111

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser 
        


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 5


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  can be repeated n times, where n is an integer including, e.g., 
       1, 2, 3, 4, 5, and 6

<400>  112

Gly Gly Gly Gly Ser 
1               5   


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 6

<400>  113

Asp Gly Gly Gly Ser 
1               5   


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 7

<400>  114

Thr Gly Glu Lys Pro 
1               5   


<210>  115
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 8

<400>  115

Gly Gly Arg Arg 
1               


<210>  116
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 9

<400>  116

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210>  117
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 10

<400>  117

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  118
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 11

<400>  118

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 12

<400>  119

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 13

<400>  120

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 14

<400>  121

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  122
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 15

<400>  122

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  123
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 16

<400>  123

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


<210>  124
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 17

<400>  124

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  125
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 18

<400>  125

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  126
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Peptide (CD8Alpha)

<400>  126

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  127
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge (CD8Alpha)

<400>  127

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  128
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane domain (CD8Alpha)

<400>  128

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  129
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-stimulatory signaling domain (CD137)

<400>  129

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  130
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primary intracellular signaling domain (CD3Zeta)

<400>  130

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  131
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m971 scFv

<400>  131

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  132
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG1 Fc fragment sequence

<400>  132

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  133
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m971 VH-CH1

<400>  133

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  134
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m971 VL-CL

<400>  134

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  135
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EcoRI restriction site

<400>  135
gaattc                                                                   6


<210>  136
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SpeI restriction site

<400>  136
actagt                                                                   6


<210>  137
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  137
gccgccacc                                                                9


<210>  138
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR1 (Kabat with 5aa)

<400>  138

Ser Val Ser Met Gly 
1               5   


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CDR1 (Kabat 31-35)

<400>  139

Thr Gly Glu Phe Tyr Trp Asn 
1               5           


<210>  140
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR1 (Kabat with 5aa)

<400>  140

Thr Tyr Cys Met Gly 
1               5   


<210>  141
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR1 (Kabat with 5aa)

<400>  141

Arg Tyr Cys Met Gly 
1               5   


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR1 (Kabat with 5aa)

<400>  142

Gly Tyr Cys Leu Ala 
1               5   


<210>  143
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR1 (Kabat 31-35)

<400>  143

Val Ser Ile Ala 
1               


<210>  144
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1160, LIC1161, LIC1162, LIC1163 CDR1 (Kabat with 5aa)

<400>  144

Ser Tyr Asn Met Ala 
1               5   


<210>  145
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIC1164 CDR1 (Kabat with 5aa)

<400>  145

Ser Tyr Asp Met Ala 
1               5   


