                         SEQUENCE LISTING

<110>  ɽ´Ƽ޹˾
 
<120>  PADI4ƱԼеӦ

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  695
<212>  PRT
<213>  ˹ϳ

<400>  1

Met Gly Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  30          


Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
        35                  40                  45              


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
    50                  55                  60                  


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
65                  70                  75                  80  


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
                85                  90                  95      


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
            100                 105                 110         


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
        115                 120                 125             


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
    130                 135                 140                 


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
145                 150                 155                 160 


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
                165                 170                 175     


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
            180                 185                 190         


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
        195                 200                 205             


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
    210                 215                 220                 


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
225                 230                 235                 240 


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
                245                 250                 255     


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
            260                 265                 270         


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
        275                 280                 285             


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
    290                 295                 300                 


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
305                 310                 315                 320 


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
                325                 330                 335     


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
            340                 345                 350         


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
        355                 360                 365             


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
    370                 375                 380                 


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
385                 390                 395                 400 


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
                405                 410                 415     


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
            420                 425                 430         


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
        435                 440                 445             


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
    450                 455                 460                 


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
465                 470                 475                 480 


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
                485                 490                 495     


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
            500                 505                 510         


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
        515                 520                 525             


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
    530                 535                 540                 


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
545                 550                 555                 560 


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
                565                 570                 575     


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
            580                 585                 590         


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
        595                 600                 605             


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
    610                 615                 620                 


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
625                 630                 635                 640 


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
                645                 650                 655     


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
            660                 665                 670         


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
        675                 680                 685             


Lys Trp Trp Asn Met Val Pro 
    690                 695 


<210>  2
<211>  2109
<212>  DNA
<213>  ˹ϳ

<400>  2
gaattcgccg ccaccatggg cgcttcctgg agccaccccc agttcgagaa gggtggtggc       60

agcggtggcg gcagcggagg ttcagcttgg tcccaccctc agttcgaaaa gatggcccag      120

ggtactctga tccgtgtcac ccccgagcag cctacccacg ccgtctgcgt gctgggtacc      180

ctgactcagc tggacatctg ctccagcgct cctgaggact gcacttcctt cagcatcaac      240

gcttcccctg gtgtcgtcgt ggacatcgcc cacggtcctc ccgccaagaa gaagtccacc      300

ggtagcagca cttggcctct ggaccctggt gtggaggtca ccctgactat gaaggtggct      360

tccggcagca ccggcgacca gaaggtccag atcagctact acggtcctaa gacccccccc      420

gtgaaggctc tgctgtacct gactggcgtc gagatcagcc tgtgcgctga catcacccgt      480

actggcaagg tgaagcctac ccgtgctgtg aaggaccagc gcacttggac ctggggccct      540

tgcggtcagg gtgctatcct gctggtcaac tgcgaccgtg acaacctgga gtcctccgct      600

atggactgcg aagacgacga agtgctggac agcgaggacc tgcaggacat gtccctgatg      660

actctgagca ctaagactcc caaggacttc ttcaccaacc acaccctggt cctgcacgtc      720

gcccgcagcg agatggacaa ggtgcgcgtc ttccaggcta cccgcggtaa actgtcctcc      780

aagtgcagcg tcgtgctggg ccctaagtgg ccttcccact acctgatggt ccccggtggt      840

aaacacaaca tggacttcta cgtcgaggcc ctggccttcc ctgacactga cttccctggt      900

ctgatcactc tgaccatctc cctgctggac actagcaacc tggaactgcc cgaggccgtg      960

gtgttccagg acagcgtcgt gttccgtgtg gctccctgga tcatgacccc caacacccag     1020

ccccctcagg aagtgtacgc ttgcagcatc ttcgaaaacg aggacttcct gaagagcgtc     1080

actaccctgg ctatgaaggc caagtgcaag ctgaccatct gccctgagga agagaacatg     1140

gacgaccagt ggatgcagga cgaaatggag atcggctaca tccaggctcc tcacaagact     1200

ctgcccgtcg tgttcgacag cccccgtaac cgcggtctga aggaatttcc catcaagcgc     1260

gtgatgggcc ctgacttcgg ttacgtgacc cgtggtcccc agactggcgg tatctccggc     1320

ctggacagct tcggcaacct ggaggtctcc ccccctgtga ctgtgcgcgg caaggagtac     1380

cccctgggtc gcatcctgtt cggcgactcc tgctaccctt ccaacgactc ccgtcagatg     1440

caccaggctc tgcaggactt cctgagcgcc cagcaggtgc aggctcctgt gaagctgtac     1500

agcgactggc tgagcgtcgg tcacgtcgac gagttcctgt ccttcgtgcc tgcccctgac     1560

cgcaagggct tccgcctgct gctggccagc cccagatcct gctacaagct gttccaggag     1620

cagcagaacg aaggccacgg tgaggctctg ctgttcgaag gcatcaagaa gaagaagcag     1680

cagaagatca agaacatcct gagcaacaag actctgcgcg aacacaactc cttcgtcgaa     1740

cgttgcatcg actggaaccg tgaactgctg aagcgcgagc tgggcctggc cgagagcgac     1800

atcatcgaca tccctcagct gttcaagctg aaggaatttt ctaaggccga agcctttttc     1860

cctaacatgg tgaacatgct ggtgctgggt aaacacctgg gtatccctaa gcccttcggt     1920

cccgtcatca acggccgctg ctgcctggag gagaaggtct gctccctgct ggagcccctg     1980

ggtctgcagt gcaccttcat caacgacttc ttcacttacc acatccgtca cggcgaagtg     2040

cactgcggta ccaacgtgcg ccgcaagcct ttctccttca agtggtggaa catggtgcct     2100

taaaagctt                                                             2109


<210>  3
<211>  469
<212>  PRT
<213>  ˹ϳ

<400>  3

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Cys Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Tyr Tyr Arg Phe Asp Glu Gly Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  4
<211>  1419
<212>  DNA
<213>  ˹ϳ

<400>  4
gccgccacca tgaagcacct gtggttcttt ctgctgctgg tggccgctcc tagatgggtg       60

ctgagcgagg tgaagctgca ggagtcagga cctgggatat tgcagccctc ccagaccctc      120

agtctgactt gttctttctc tgggttttca ctgagcactt ctggtatgtg tgtaggctgg      180

attcgtcagc cttcagggaa gggtctggag tggctggcac acatttggtg ggatgatgac      240

aagcgctata acccagccct taagagccga ctgacaatct ccaaggatac ctccagcaac      300

caggttttcc tcaagatcgc cagtgtggac actgcagata ctgccacata ctactgtgct      360

cgatactata ggttcgacga agggtttgac tactggggcc aaggcaccac tctcacagtc      420

tcctcagcta gcaccaaggg accttctgtg ttccctctgg ctccttcttc taagtccact      480

tccggtggta cagcagctct gggttgtctg gtgaaggatt acttcccaga accagtgact      540

gtgtcctgga actccggagc tctgacttct ggagtgcata ctttcccagc agtgctgcaa      600

tctagcggac tgtactctct gtcttccgtg gtgactgtgc cttcttcttc cctggggact      660

caaacttaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagccaaaga gctgcgataa gacccacacc tgtccacctt gtccagctcc agaactgctg      780

ggtgggcctt ctgtgtttct gttcccacct aagccaaagg ataccctgat gatctctagg      840

accccagaag tgacctgtgt ggtcgtcgat gtgtctcatg aagaccctga agtgaagttc      900

aactggtacg tggacggggt ggaagtgcat aacgcaaaga ccaagcccag ggaagagcaa      960

tacaactcca cctacagggt ggtctccgtc ctgacagtcc tgcatcagga ttggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaat aaagccctgc ctgcccctat cgagaaaacc     1080

attagcaaag ccaaaggcca gcccagggag ccccaggtct atacactgcc ccccagcagg     1140

gaggagatga caaaaaatca ggtcagcctg acatgcctgg tcaaaggctt ttatcccagc     1200

gacattgccg tcgagtggga gtccaatggc cagcccgaga ataattataa aacaacaccc     1260

cccgtcctgg acagcgacgg cagctttttt ctgtatagca aactgacagt cgataaaagc     1320

aggtggcagc agggcaatgt cttttcctgc agcgtcatgc acgaggccct gcacaatcac     1380

tatactcaga aaagcctgag cctgtccccc gggaaatga                            1419


<210>  5
<211>  239
<212>  PRT
<213>  ˹ϳ

<400>  5

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Ile Thr Gln Asp Glu Leu Ser Asn Pro 
            20                  25                  30          


Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu His Ser Asp Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Asn Leu Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  6
<211>  729
<212>  DNA
<213>  ˹ϳ

<400>  6
gccgccacca tggtgctgca gacccaggtg ttcatctctc tgctgctgtg gatctccggc       60

gcctacggcg atatcgtgat aacccaagat gaactctcca atccagtcac tcttggaaca      120

tcagcttcca tctcctgcag gtctagtaag agtctcctac atagtgatgg catcacttat      180

ttgtattggt atctgcagaa gccaggccag tctcctcagc tcctgattta tcagatgtcc      240

aaccttgcct caggagtccc agacaggttc agtagcagtg ggtcaggaac tgatttcaca      300

ctgagaatca gcagagtgga ggctgaggat gtgggtgttt attactgtgc tcaaaatcta      360

gaacttccgc tcacgttcgg tgctgggacc aagctggagc tgaaacgtac ggtggctgca      420

ccttctgtgt tcatcttccc tccatctgat gagcagctga agtctggaac cgcatctgtc      480

gtctgtctgc tgaacaactt ttaccccagg gaggctaagg tccaatggaa ggtggacaac      540

gccctgcagt ctggtaatag ccaggaaagc gtgaccgaac aggattccaa ggactccacc      600

tactccctgt cctccacact gacactgagc aaagccgact atgaaaagca caaagtgtat      660

gcctgcgagg tcactcatca gggcctgtcc agccccgtga ctaaaagctt taataggggg      720

gagtgctga                                                              729


<210>  7
<211>  463
<212>  PRT
<213>  ˹ϳ

<400>  7

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Ser Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Asn Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Ala Val His Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Cys Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Ala Gly Ile Pro Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  8
<211>  1401
<212>  DNA
<213>  ˹ϳ

<400>  8
gccgccacca tgaagcacct gtggttcttt ctgctgctgg tggccgctcc tagatgggtg       60

ctgagcgagg tgaagctgca ggagtcagga cctagcctgg tggctccatc ccagaacctg      120

agcatcacct gcacagtgtc cggcttcagc ctgacctctt acgctgtgca ttggtttagg      180

cagccacctg gcaagggact ggagtggctg ggcgtgatct gggctggagg ctccacaaac      240

tgcaattctg ctctgatgtc ccggctgtct atctccaagg acaacagcaa gtctcaggtg      300

ttcctgaaga tgaactccct gcagaccgac gatacagcca tgtactattg tgcccgcgag      360

gctggcatcc catttgatta ttggggccag ggcaccacac tgaccgtggc tagcaccaag      420

ggaccttctg tgttccctct ggctccttct tctaagtcca cttccggtgg tacagcagct      480

ctgggttgtc tggtgaagga ttacttccca gaaccagtga ctgtgtcctg gaactccgga      540

gctctgactt ctggagtgca tactttccca gcagtgctgc aatctagcgg actgtactct      600

ctgtcttccg tggtgactgt gccttcttct tccctgggga ctcaaactta catctgcaac      660

gtgaaccaca agccctccaa caccaaggtg gacaagaagg tggagccaaa gagctgcgat      720

aagacccaca cctgtccacc ttgtccagct ccagaactgc tgggtgggcc ttctgtgttt      780

ctgttcccac ctaagccaaa ggataccctg atgatctcta ggaccccaga agtgacctgt      840

gtggtcgtcg atgtgtctca tgaagaccct gaagtgaagt tcaactggta cgtggacggg      900

gtggaagtgc ataacgcaaa gaccaagccc agggaagagc aatacaactc cacctacagg      960

gtggtctccg tcctgacagt cctgcatcag gattggctga acggcaagga gtacaagtgc     1020

aaggtctcca ataaagccct gcctgcccct atcgagaaaa ccattagcaa agccaaaggc     1080

cagcccaggg agccccaggt ctatacactg ccccccagca gggaggagat gacaaaaaat     1140

caggtcagcc tgacatgcct ggtcaaaggc ttttatccca gcgacattgc cgtcgagtgg     1200

gagtccaatg gccagcccga gaataattat aaaacaacac cccccgtcct ggacagcgac     1260

ggcagctttt ttctgtatag caaactgaca gtcgataaaa gcaggtggca gcagggcaat     1320

gtcttttcct gcagcgtcat gcacgaggcc ctgcacaatc actatactca gaaaagcctg     1380

agcctgtccc ccgggaaatg a                                               1401


<210>  9
<211>  466
<212>  PRT
<213>  ˹ϳ

<400>  9

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Glu Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Asn Met Asn Trp Val Lys Gln Arg Asn Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asp Pro Tyr Asn Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Ser Val Asp Lys Ser Ser Thr 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Lys Gly Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Thr Tyr Tyr Gly Asp Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  10
<211>  1410
<212>  DNA
<213>  ˹ϳ

<400>  10
gccgccacca tgaagcacct gtggttcttt ctgctgctgg tggccgctcc tagatgggtg       60

ctgagcgagg tgcagctgca ggagtcaggc cctgagctgg agaagcccgg cgctagcgtg      120

aagatcagct gcaaggcctc cggctactcc ttcaccggct acaatatgaa ttgggtgaag      180

cagagaaacg gcaagagcct ggagtggatc ggcaacatcg atccttacaa cggcggcaca      240

aattacaatc agaagttcaa gggcaaggcc accctgtccg tggataagag cagcacaacc      300

gcctacatgc agctgaaggg cctgacatcc gaggactccg ccgtgtactt ttgcgccagg      360

gagacctact acggcgacgc catggattac tggggccagg gcaccagcgt gacagtggct      420

agcaccaagg gaccttctgt gttccctctg gctccttctt ctaagtccac ttccggtggt      480

acagcagctc tgggttgtct ggtgaaggat tacttcccag aaccagtgac tgtgtcctgg      540

aactccggag ctctgacttc tggagtgcat actttcccag cagtgctgca atctagcgga      600

ctgtactctc tgtcttccgt ggtgactgtg ccttcttctt ccctggggac tcaaacttac      660

atctgcaacg tgaaccacaa gccctccaac accaaggtgg acaagaaggt ggagccaaag      720

agctgcgata agacccacac ctgtccacct tgtccagctc cagaactgct gggtgggcct      780

tctgtgtttc tgttcccacc taagccaaag gataccctga tgatctctag gaccccagaa      840

gtgacctgtg tggtcgtcga tgtgtctcat gaagaccctg aagtgaagtt caactggtac      900

gtggacgggg tggaagtgca taacgcaaag accaagccca gggaagagca atacaactcc      960

acctacaggg tggtctccgt cctgacagtc ctgcatcagg attggctgaa cggcaaggag     1020

tacaagtgca aggtctccaa taaagccctg cctgccccta tcgagaaaac cattagcaaa     1080

gccaaaggcc agcccaggga gccccaggtc tatacactgc cccccagcag ggaggagatg     1140

acaaaaaatc aggtcagcct gacatgcctg gtcaaaggct tttatcccag cgacattgcc     1200

gtcgagtggg agtccaatgg ccagcccgag aataattata aaacaacacc ccccgtcctg     1260

gacagcgacg gcagcttttt tctgtatagc aaactgacag tcgataaaag caggtggcag     1320

cagggcaatg tcttttcctg cagcgtcatg cacgaggccc tgcacaatca ctatactcag     1380

aaaagcctga gcctgtcccc cgggaaatga                                      1410


<210>  11
<211>  238
<212>  PRT
<213>  ˹ϳ

<400>  11

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Thr Asn Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  12
<211>  726
<212>  DNA
<213>  ˹ϳ

<400>  12
gccgccacca tggtgctgca gacccaggtg ttcatctctc tgctgctgtg gatctccggc       60

gcctacggcg acattgtgct gacccaatct ccagcttctt tggttgtgtc tctagggcag      120

agggccacca tatcctgcag agccagtgaa agtgttgata gttatggcaa tagttttatg      180

cactggtatc agcagaaacc aggacagcca cccaaactcc tcatctatcg tgcatccaac      240

ctagaatctg ggatccctgc caggttcagt ggcagtgggt ctaggacaga cttcaccctc      300

accattaatc ctgtggaggc tgatgatgtt gcaacctatt actgtcagca aactaatgag      360

gatccattca cgttcggctc ggggacaaag ttggaaataa aacgtacggt ggctgcacct      420

tctgtgttca tcttccctcc atctgatgag cagctgaagt ctggaaccgc atctgtcgtc      480

tgtctgctga acaactttta ccccagggag gctaaggtcc aatggaaggt ggacaacgcc      540

ctgcagtctg gtaatagcca ggaaagcgtg accgaacagg attccaagga ctccacctac      600

tccctgtcct ccacactgac actgagcaaa gccgactatg aaaagcacaa agtgtatgcc      660

tgcgaggtca ctcatcaggg cctgtccagc cccgtgacta aaagctttaa taggggggag      720

tgctga                                                                 726


