                         SEQUENCE LISTING

<110>  Exocure Biosciences
       Park, Kyong-su
       Lotvall, Jan
 
<120>  BACTERIA-DERIVED VESICLES AND USE THEREOF FOR GENERATING IMMUNE 
       RESPONSE TO SARS-COV-2

<130>  EXOC-005WO

<140>  PCT/US2021/040688
<141>  2021-07-07

<150>  US 63/049,967
<151>  2020-07-09

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  654
<212>  PRT
<213>  SARS-CoV-2

<400>  1

Ser Asp Leu Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn 
1               5                   10                  15      


Tyr Thr Gln His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu 
            20                  25                  30          


Ile Phe Arg Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro 
        35                  40                  45              


Phe Tyr Ser Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly 
    50                  55                  60                  


Asn Pro Val Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu 
65                  70                  75                  80  


Lys Ser Asn Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn 
                85                  90                  95      


Lys Ser Gln Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile 
            100                 105                 110         


Arg Ala Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser 
        115                 120                 125             


Lys Pro Met Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe 
    130                 135                 140                 


Asn Cys Thr Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser 
145                 150                 155                 160 


Glu Lys Ser Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn 
                165                 170                 175     


Lys Asp Gly Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val 
            180                 185                 190         


Val Arg Asp Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys 
        195                 200                 205             


Leu Pro Leu Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala 
    210                 215                 220                 


Phe Ser Pro Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe 
225                 230                 235                 240 


Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn 
                245                 250                 255     


Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu 
            260                 265                 270         


Leu Lys Cys Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln 
        275                 280                 285             


Thr Ser Asn Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro 
    290                 295                 300                 


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys 
305                 310                 315                 320 


Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val 
                325                 330                 335     


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys 
            340                 345                 350         


Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn 
        355                 360                 365             


Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile 
    370                 375                 380                 


Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
385                 390                 395                 400 


Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp 
                405                 410                 415     


Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His 
            420                 425                 430         


Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser 
        435                 440                 445             


Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro 
    450                 455                 460                 


Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro 
465                 470                 475                 480 


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr 
                485                 490                 495     


Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val 
            500                 505                 510         


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser 
        515                 520                 525             


Ser Lys Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp 
    530                 535                 540                 


Phe Thr Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile 
545                 550                 555                 560 


Ser Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
                565                 570                 575     


Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp 
            580                 585                 590         


Val Ser Thr Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile 
        595                 600                 605             


Tyr Ser Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile 
    610                 615                 620                 


Gly Ala Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
625                 630                 635                 640 


Ala Gly Ile Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg 
                645                 650                 


<210>  2
<211>  222
<212>  PRT
<213>  SARS-CoV-2

<400>  2

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
    210                 215                 220         


