                         SEQUENCE LISTING

<110>  Rutgers, The State University of New Jersey
       PhageNova Bio, Inc.
       Pasqualini, Renata
       Arap, Wadih
       Libutti, Steven
       Markosian, Christopher
       Staquicini, Daniela
       Tang, Fenny
       Smith, Tracey
       Yao, Virginia
 
<120>  ENHANCING IMMUNE RESPONSES THROUGH TARGETED ANTIGEN EXPRESSION

<130>  370602-7034WO1(00090)

<150>  US Provisional Application No. 63/048,279
<151>  2020-07-06

<150>  US Provisional Application No. 63/161,136
<151>  2021-03-15

<160>  136   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LN Targeting Peptide

<400>  1

Pro Thr Cys Ala Tyr Gly Trp Cys Ala 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LN Targeting Peptide

<400>  2

Trp Ser Cys Ala Arg Pro Leu Cys Gly 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lymphatic Channel Targeting Peptide

<400>  3

Cys Gly Leu Thr Phe Lys Ser Leu Cys 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aerosol delivery peptide

<400>  4

Cys Ala Lys Ser Met Gly Asp Ile Val Cys 
1               5                   10  


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RGD4C-targeting peptide

<400>  5

Ala Cys Asp Cys Arg Gly Asp Cys Phe Cys Gly 
1               5                   10      


<210>  6
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RGD4C- targeting peptide

<400>  6
gcgtgtgatt gtagggggga ttgtttttgt ggc                                    33


<210>  7
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LN-targeting peptide nucleic acid

<400>  7
ccgacctgtg cgtatggctg gtgtgcg                                           27


<210>  8
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LN-targeting peptide nucleic acid

<400>  8
tggagctgtg cgcgcccgct gtgtggc                                           27


<210>  9
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lymphatic channel-targeting peptide

<400>  9
tgtggcctga ccttcaaaag cctgtgt                                           27


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  10

Cys Asn Gly Thr Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Gln Gly 
1               5                   10                  15      


Tyr Gly Cys 
            


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  11

Cys Asn Thr Asn Gln Gly Gly Tyr Gly Gly Tyr Gln Tyr Cys 
1               5                   10                  


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  12

Cys Tyr Gln Tyr Gly Gly Gly Gly Tyr Gly Gly Gln Asn Thr Gly Gly 
1               5                   10                  15      


Gly Gly Asn Cys 
            20  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  13

Cys Tyr Gln Tyr Gly Gly Tyr Gly Gln Asn Thr Gly Asn Cys 
1               5                   10                  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  14

Cys Gly Gly Leu Gln Tyr Gly Gly Gly Gly Tyr Gly Gln Thr Asn Gly 
1               5                   10                  15      


Gly Gly Asn Cys 
            20  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  15

Cys Leu Gln Tyr Gly Gly Tyr Gln Thr Asn Gly Gly Asn Cys 
1               5                   10                  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  16

Cys Asn Gly Gly Gly Asn Thr Gln Gly Tyr Gly Tyr Ser Gln Tyr Gly 
1               5                   10                  15      


Gly Gly Thr Cys 
            20  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  17

Cys Asn Gly Asn Thr Gln Tyr Tyr Ser Gln Tyr Gly Thr Cys 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  18

Cys His Thr Asn Ser Trp Gly Gly Gly Thr Asn Asn Cys Cys 
1               5                   10                  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  19

Cys Tyr Ser Asn Asn Ser Gly Gly Thr Gly Gly Asn Glu Gln Cys 
1               5                   10                  15  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  20

Cys Tyr Gly Thr Gln Asn Gly Thr Gly Gly Gly Tyr Gly Gly Thr Gln 
1               5                   10                  15      


Asn Gly Thr Cys 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein optimized epitope

<400>  21

Cys Asn Asn Ser Gln Gly Gly Gly Gly Gly Asn Asn Ser Gln Gly Gly 
1               5                   10                  15      


Gly Gly Gly Cys 
            20  


<210>  22
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 336-361)

<400>  22

Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
1               5                   10                  15      


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
            20                  25      


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 379-391)

<400>  23

Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
1               5                   10              


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 480-488)

<400>  24

Cys Asn Gly Val Glu Gly Phe Asn Cys 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 662-671)

<400>  25

Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
1               5                   10  


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 738-760)

<400>  26

Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu 
1               5                   10                  15      


Leu Gln Tyr Gly Ser Phe Cys 
            20              


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 1032-1043)

<400>  27

Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe Cys 
1               5                   10          


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lung-targeting peptide

<400>  28

Cys Gly Ser Pro Gly Trp Val Arg Cys 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRP78-targeting peptide

<400>  29

Cys Ser Asn Thr Arg Val Ala Pro Cys 
1               5                   


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRP78-targeting peptide

<400>  30

Trp Ile Phe Pro Trp Ile Gln Leu 
1               5               


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Spike protein epitope (aa 553-570)

<400>  31

Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp 
1               5                   10                  15      


Ile Ala 
        


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Spike protein epitope (aa 809-826)

<400>  32

Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn 
1               5                   10                  15      


Lys Val 
        


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Spike protein epitope (aa 369-386)

<400>  33

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
1               5                   10                  15      


Thr Lys 
        


<210>  34
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 129-161)

<400>  34

Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
1               5                   10                  15      


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
            20                  25                  30          


Ser 
    


<210>  35
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 252-284)

<400>  35

Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
1               5                   10                  15      


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
            20                  25                  30          


Thr 
    


<210>  36
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 339-371)

<400>  36

Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
1               5                   10                  15      


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
            20                  25                  30          


Ser 
    


<210>  37
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 462-494)

<400>  37

Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
1               5                   10                  15      


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
            20                  25                  30          


Ser 
    


<210>  38
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 673-705)

<400>  38

Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
1               5                   10                  15      


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
            20                  25                  30          


Val 
    


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 166-180)

<400>  39

Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 751-765)

<400>  40

Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 866-880)

<400>  41

Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 801-815)

<400>  42

Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
1               5                   10                  15  


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 553-564)

<400>  43

Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 577-588)

<400>  44

Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
1               5                   10          


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 595-612)

<400>  45

Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
1               5                   10                  15      


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 625-642)

<400>  46

His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
1               5                   10                  15      


Asn Val 
        


<210>  47
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 661-684)

<400>  47

Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
1               5                   10                  15      


Gln Thr Asn Ser Pro Arg Arg Ala 
            20                  


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 1148-1159)

<400>  48

Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His 
1               5                   10          


<210>  49
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 21-45)

<400>  49

Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
1               5                   10                  15      


Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25  


<210>  50
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 221-245)

<400>  50

Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
1               5                   10                  15      


Arg Phe Gln Thr Leu Leu Ala Leu His 
            20                  25  


<210>  51
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 261-285)

<400>  51

Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
1               5                   10                  15      


Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            20                  25  


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 330-349)

<400>  52

Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
1               5                   10                  15      


Arg Phe Ala Ser 
            20  


<210>  53
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 370-394)

<400>  53

Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
1               5                   10                  15      


Lys Leu Asn Asp Leu Cys Phe Thr Asn 
            20                  25  


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 375-394)

<400>  54

Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
1               5                   10                  15      


Cys Phe Thr Asn 
            20  


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 406-417)

<400>  55

Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
1               5                   10          


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 414-427)

<400>  56

Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
1               5                   10                  


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 418-430)

<400>  57

Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
1               5                   10              


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 424-428)

<400>  58

Lys Leu Pro Asp Asp 
1               5   


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 438-448)

<400>  59

Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
1               5                   10      


<210>  60
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 450-469)

<400>  60

Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
1               5                   10                  15      


Arg Asp Ile Ser 
            20  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 454-463)

<400>  61

Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
1               5                   10  


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 459-467)

<400>  62

Ser Asn Leu Lys Pro Phe Glu Arg Asp 
1               5                   


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 478-488)

<400>  63

Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
1               5                   10      


<210>  64
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 480-499)

<400>  64

Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
1               5                   10                  15      


Gly Phe Gln Pro 
            20  


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 504-507)

<400>  65

Gly Tyr Gln Pro 
1               


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 514-518)

<400>  66

Ser Phe Glu Leu Leu 
1               5   


<210>  67
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 551-570)

<400>  67

Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly 
1               5                   10                  15      


Arg Asp Ile Ala 
            20  


<210>  68
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 655-672)

<400>  68

His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
1               5                   10                  15      


Cys Ala 
        


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 766-785)

<400>  69

Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
1               5                   10                  15      


Phe Ala Gln Val 
            20  


<210>  70
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 787-822)

<400>  70

Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
1               5                   10                  15      


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
            20                  25                  30          


Glu Asp Leu Leu 
        35      


<210>  71
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 811-830)

<400>  71

Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
1               5                   10                  15      


Thr Leu Ala Asp 
            20  


<210>  72
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 1144-1163)

<400>  72

Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His 
1               5                   10                  15      


Thr Ser Pro Asp 
            20  


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 1147-1158)

<400>  73

Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 
1               5                   10          


<210>  74
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 131-166)

<400>  74

Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His 
1               5                   10                  15      


Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser 
            20                  25                  30          


Ala Asn Asn Cys 
        35      


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 291-301)

<400>  75

Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
1               5                   10      


<210>  76
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 443-495) w flanking cys residues

<400>  76

Cys Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
1               5                   10                  15      


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
            20                  25                  30          


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
        35                  40                  45              


Phe Pro Leu Gln Ser Tyr Cys 
    50                  55  


<210>  77
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 443-495_E484K) w flanking cys residues

<400>  77

Cys Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
1               5                   10                  15      


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
            20                  25                  30          


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr 
        35                  40                  45              


Phe Pro Leu Gln Ser Tyr Cys 
    50                  55  


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 480-488_E484K)

<400>  78

Cys Asn Gly Val Lys Gly Phe Asn Cys 
1               5                   


<210>  79
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 538-590)

<400>  79

Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
1               5                   10                  15      


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
            20                  25                  30          


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
        35                  40                  45              


Asp Ile Thr Pro Cys 
    50              


<210>  80
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 617-649)

<400>  80

Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr 
1               5                   10                  15      


Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly 
            20                  25                  30          


Cys 
    


<210>  81
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aerosol delivery peptide nucleic acid

<400>  81
tgtgcgaaaa gcatgggcga tatcgtgtgt                                        30


<210>  82
<211>  4179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHV type 1 S protein

<400>  82
gaattctgaa tgaaatatac aagttatatc ttggcttttc agctctgcat cgttttgggt       60

tctcttggca tgctgtttgt cgtgtttatt ctcctaatac cctcttgttt agggtatatt      120

ggtgacttta gatgtatcca gctcgtgaac tcaaacggca acaacgcttc tgcgccaagc      180

attagcattg aaactgtcga tgtttccaaa ggccttggta cttattatgt tttagatcga      240

gtttatttaa atgccacatt attgcttact ggttattatc ctgtggacgg ttccaattat      300

aggaatctcg cgcttacagg cactaatacc ctaagcctta attggtataa accacccttt      360

ttatcagagt ttaatgatgg catatttgct aaggtaaaga accttaaagc atctctgccc      420

gctggctcat cggcttattt ccctactatt ataataggca gtggttttgg taacaccgcc      480

tatactatag taatggaacc atataatggt ataattatgg catctatttg ccagtacacc      540

atttgtcaat taccgtatac tgattgtaaa cctaatacag gcggtaatag tattataggt      600

ttttggcaca cagatataaa atcccctgtg tgcattttaa agcgtaattt cacgtttaat      660

gttaatgccg attggctcta ttttcatttt taccaacagg gtggtacttt ttatgcgtat      720

tatgcagatg tagcttctgc tactacgttt ttatttagta tttatattgg cgatgtttta      780

acgcaattct ttgtgttgcc ttttaattgt gaacctgata aggctggtgt tatatcaccg      840

cagtattggg tcacaccttt agttgagcgc caatatttgt ttaattttaa ccaaaagggt      900

attattacta gtgctgttga ttgtgctagt agttataccg ctgaaattaa atgcaagact      960

caaagtatga atcctagtac gggagtctat gatctcactg gttacactgt tcaacctgtt     1020

ggtttagtgt accgaagagt tagaaatttg cctgattgta aaatagagga ttggctcacc     1080

gctaaaagcg tgccgtctcc tctcaattgg gaacgtaaaa catttcaaaa ttgtaacttt     1140

aacctgagca gtctattaag atttgtccag gctgagtcac tctcatgtag taatatagat     1200

gcttccaaag tttatggaat gtgctttggc agcgtatcta tagataaatt tgcaataccc     1260

aataggagac gcgttgacct ccaaataggc aattctgggt ttttgcagtc ttttaattat     1320

aaaatagatt caagggcgac ttcttgccag ctttattata gtcttgcaca aaataatgtc     1380

accgttaata accataaccc gtcctcctgg aataggcgat atggatttaa cgatgtggca     1440

acatttggta gtggtaaaca tgacgttgca tatgctgaag agtgttttac tgttggtaat     1500

gattattgcc catgtgctaa ccccagcata gtatcgccat gcacgcaaga taaacctaag     1560

gctgctaatt gtccagtagg tacacgcaat cgagagtgta accctctggc gcttggcggt     1620

aatttattta agtgcgactg cacatgtaac cctagcccac taactaccta cgaccttcgc     1680

tgcctccagg ctaggagcat gctaggggta ggtgaccatt gtgaaggact tggtgtttta     1740

gaagataaat gtggtggaag caacgtttgc aattgtactg cagatgcttt tgttggctgg     1800

tctacggata gttgtctatc caaaggccgc tgccacattt tctcgaattt gttattaaat     1860

ggcattaata gtggaaccac ttgctccact gatttacagt tgcctaatac tgaagtggtt     1920

actggcgttt gtgtcaagta tcatctcttc ggtattactg gtcaaggtgt ttttaaggag     1980

gttaaagccg actactatca tagctggcag aatctcttat atgatgttaa tggcaatctg     2040

gaaggtttcc gcgacatcat taccaataaa acttatacta ttagaagctg ttatagcggg     2100

cgagtttcgg ctgcatatca tcaagatgca cctgaacctg cgctgctata tcgcaattta     2160

aaatgtgatt atgtctttaa caacaacatc tcccgtgagg agaccccact taactatttt     2220

gatagttatt tgggctgtgt tgttaatgct gataactcaa ctgaagaagc tgttgctgtg     2280

tgtgatctac gtatgggtag tggcctttgc gtcaactatt caacgtcaca tcgagctcgc     2340

aggtccatca gtacgggtta taaattaact acttttgaac catttacagt tagcattgtc     2400

aatgatagtg ttcagtctgt gggtggatta tatgagatgc aaataccaat caattttact     2460

ataggacaac accaggagtt cattcaaact agagctccaa aggtaactat agattgtgcg     2520

gcttttgtct gtggtgatta cacagcatgc cggcagcagt tggttgagta tggatcattc     2580

tgtgataata ttaatgccat tcttggcgag gttaataacc tcatagatac tatgcaactg     2640

caggttgcta gtgccctgat acaaggtgtc acgctaagtt cccgcttggc tgatggcatt     2700

ggtggtcaga ttgatgatat taattttagt cctctgttag gctgtctagg ttcagattgt     2760

ggtgaaggaa ccactgctgc actaaaggga cggtcggtta tagaggatat gctgttcgat     2820

aaagtcaaac tatcagatgt tggctttgtt gaagcatata ataattgcac tggtggtcag     2880

gaagtcagag acctactatg tgtgcaatct tttaatggca taaaagtgct gcctcctgta     2940

ttatccgaga gtcagatctc cggatataca gctggtgcta ctgcgtctgc tatgttccca     3000

ccttggtctg cagccgcggg tgtgccattt tctttaagtg ttcaatatag aattaatggt     3060

ctgggtgtca ctatgaatgt tcttagtgaa aaccagaaaa tgatagctag tgctttcaac     3120

aatgcgattg gtgctataca ggagggcttt gatgccacta attctgcatt agcaaaaatt     3180

caatccgttg tgaatgcaaa tgctgaagca cttaataatc tgttgcaaca attgtccaac     3240

agatttggtg caattagtgc ttctttacag gaaattctat cccgccttga tgctcttgaa     3300

gcgcaggctc agatagaccg tcttataaat ggcagattaa ctgcacttaa tgcatatgtt     3360

tctaagcagc tgagtgacat gaccctagtt aaggtaagtg ccgctcaagc tatagagaaa     3420

gttaatgagt gtgttaaaag ccaatcacct aggattaatt tctgtggcaa tggcaatcat     3480

atattgtcat tagtccagag tgcgccttat ggcttatatt ttatacactt cagctatgtg     3540

cctacatcct ttacaacggt aaatgtgagt cctggacttt gcatttctgg tgatagagga     3600

ttagcaccta aagctggata ttttgttcaa gataatggag agtggaagtt cactggtagt     3660

ggttattact accctgaacc cataaatgat aaaaacagtg tcgttatgag tagttgtgca     3720

gtaaactaca caaaagcgcc tgaagttttc ttgaacactt caataccaaa tctacccgac     3780

tttaaggagg agttagataa atggtttaag aatcagacgt ccattgcgcc tgatttatct     3840

ctcgatttcg agaaattaaa tgttactttc ctggacctga ccgatgagat gaacaggatt     3900

caggagtcaa ttaagaagtt aaatgagagc tacatcaacc tcaaggaagt tggcacatat     3960

gaaatgtatg tgaaatggcc ttggtacatt tggttgctaa ttggattagc tggtgtagct     4020

gtttgtgtgt tgttattctt tatatgctgc tgcacaggtt gcggctcatg ttgttttaag     4080

aaatgtggaa attgttgtga tgagtatgga ggacaccagg atagtattgt catccataat     4140

atatcctctc acgaggattg aggatcctct agagtcgac                            4179


<210>  83
<211>  1391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHV type 1 S protein

<400>  83

Glu Phe Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile 
1               5                   10                  15      


Val Leu Gly Ser Leu Gly Met Leu Phe Val Val Phe Ile Leu Leu Ile 
            20                  25                  30          


Pro Ser Cys Leu Gly Tyr Ile Gly Asp Phe Arg Cys Ile Gln Leu Val 
        35                  40                  45              


Asn Ser Asn Gly Asn Asn Ala Ser Ala Pro Ser Ile Ser Ile Glu Thr 
    50                  55                  60                  


Val Asp Val Ser Lys Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val 
65                  70                  75                  80  


Tyr Leu Asn Ala Thr Leu Leu Leu Thr Gly Tyr Tyr Pro Val Asp Gly 
                85                  90                  95      


Ser Asn Tyr Arg Asn Leu Ala Leu Thr Gly Thr Asn Thr Leu Ser Leu 
            100                 105                 110         


Asn Trp Tyr Lys Pro Pro Phe Leu Ser Glu Phe Asn Asp Gly Ile Phe 
        115                 120                 125             


Ala Lys Val Lys Asn Leu Lys Ala Ser Leu Pro Ala Gly Ser Ser Ala 
    130                 135                 140                 


Tyr Phe Pro Thr Ile Ile Ile Gly Ser Gly Phe Gly Asn Thr Ala Tyr 
145                 150                 155                 160 


Thr Ile Val Met Glu Pro Tyr Asn Gly Ile Ile Met Ala Ser Ile Cys 
                165                 170                 175     


Gln Tyr Thr Ile Cys Gln Leu Pro Tyr Thr Asp Cys Lys Pro Asn Thr 
            180                 185                 190         


Gly Gly Asn Ser Ile Ile Gly Phe Trp His Thr Asp Ile Lys Ser Pro 
        195                 200                 205             


Val Cys Ile Leu Lys Arg Asn Phe Thr Phe Asn Val Asn Ala Asp Trp 
    210                 215                 220                 


Leu Tyr Phe His Phe Tyr Gln Gln Gly Gly Thr Phe Tyr Ala Tyr Tyr 
225                 230                 235                 240 


Ala Asp Val Ala Ser Ala Thr Thr Phe Leu Phe Ser Ile Tyr Ile Gly 
                245                 250                 255     


Asp Val Leu Thr Gln Phe Phe Val Leu Pro Phe Asn Cys Glu Pro Asp 
            260                 265                 270         


Lys Ala Gly Val Ile Ser Pro Gln Tyr Trp Val Thr Pro Leu Val Glu 
        275                 280                 285             


Arg Gln Tyr Leu Phe Asn Phe Asn Gln Lys Gly Ile Ile Thr Ser Ala 
    290                 295                 300                 


Val Asp Cys Ala Ser Ser Tyr Thr Ala Glu Ile Lys Cys Lys Thr Gln 
305                 310                 315                 320 


Ser Met Asn Pro Ser Thr Gly Val Tyr Asp Leu Thr Gly Tyr Thr Val 
                325                 330                 335     


Gln Pro Val Gly Leu Val Tyr Arg Arg Val Arg Asn Leu Pro Asp Cys 
            340                 345                 350         


Lys Ile Glu Asp Trp Leu Thr Ala Lys Ser Val Pro Ser Pro Leu Asn 
        355                 360                 365             


Trp Glu Arg Lys Thr Phe Gln Asn Cys Asn Phe Asn Leu Ser Ser Leu 
    370                 375                 380                 


Leu Arg Phe Val Gln Ala Glu Ser Leu Ser Cys Ser Asn Ile Asp Ala 
385                 390                 395                 400 


Ser Lys Val Tyr Gly Met Cys Phe Gly Ser Val Ser Ile Asp Lys Phe 
                405                 410                 415     


Ala Ile Pro Asn Arg Arg Arg Val Asp Leu Gln Ile Gly Asn Ser Gly 
            420                 425                 430         


Phe Leu Gln Ser Phe Asn Tyr Lys Ile Asp Ser Arg Ala Thr Ser Cys 
        435                 440                 445             


Gln Leu Tyr Tyr Ser Leu Ala Gln Asn Asn Val Thr Val Asn Asn His 
    450                 455                 460                 


Asn Pro Ser Ser Trp Asn Arg Arg Tyr Gly Phe Asn Asp Val Ala Thr 
465                 470                 475                 480 


Phe Gly Ser Gly Lys His Asp Val Ala Tyr Ala Glu Glu Cys Phe Thr 
                485                 490                 495     


Val Gly Asn Asp Tyr Cys Pro Cys Ala Asn Pro Ser Ile Val Ser Pro 
            500                 505                 510         


Cys Thr Gln Asp Lys Pro Lys Ala Ala Asn Cys Pro Val Gly Thr Arg 
        515                 520                 525             


Asn Arg Glu Cys Asn Pro Leu Ala Leu Gly Gly Asn Leu Phe Lys Cys 
    530                 535                 540                 


Asp Cys Thr Cys Asn Pro Ser Pro Leu Thr Thr Tyr Asp Leu Arg Cys 
545                 550                 555                 560 


Leu Gln Ala Arg Ser Met Leu Gly Val Gly Asp His Cys Glu Gly Leu 
                565                 570                 575     


Gly Val Leu Glu Asp Lys Cys Gly Gly Ser Asn Val Cys Asn Cys Thr 
            580                 585                 590         


Ala Asp Ala Phe Val Gly Trp Ser Thr Asp Ser Cys Leu Ser Lys Gly 
        595                 600                 605             


Arg Cys His Ile Phe Ser Asn Leu Leu Leu Asn Gly Ile Asn Ser Gly 
    610                 615                 620                 


Thr Thr Cys Ser Thr Asp Leu Gln Leu Pro Asn Thr Glu Val Val Thr 
625                 630                 635                 640 


Gly Val Cys Val Lys Tyr His Leu Phe Gly Ile Thr Gly Gln Gly Val 
                645                 650                 655     


Phe Lys Glu Val Lys Ala Asp Tyr Tyr His Ser Trp Gln Asn Leu Leu 
            660                 665                 670         


Tyr Asp Val Asn Gly Asn Leu Glu Gly Phe Arg Asp Ile Ile Thr Asn 
        675                 680                 685             


Lys Thr Tyr Thr Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala 
    690                 695                 700                 


Tyr His Gln Asp Ala Pro Glu Pro Ala Leu Leu Tyr Arg Asn Leu Lys 
705                 710                 715                 720 


Cys Asp Tyr Val Phe Asn Asn Asn Ile Ser Arg Glu Glu Thr Pro Leu 
                725                 730                 735     


Asn Tyr Phe Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Asp Asn Ser 
            740                 745                 750         


Thr Glu Glu Ala Val Ala Val Cys Asp Leu Arg Met Gly Ser Gly Leu 
        755                 760                 765             


Cys Val Asn Tyr Ser Thr Ser His Arg Ala Arg Arg Ser Ile Ser Thr 
    770                 775                 780                 


Gly Tyr Lys Leu Thr Thr Phe Glu Pro Phe Thr Val Ser Ile Val Asn 
785                 790                 795                 800 


Asp Ser Val Gln Ser Val Gly Gly Leu Tyr Glu Met Gln Ile Pro Ile 
                805                 810                 815     


Asn Phe Thr Ile Gly Gln His Gln Glu Phe Ile Gln Thr Arg Ala Pro 
            820                 825                 830         


Lys Val Thr Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Thr Ala 
        835                 840                 845             


Cys Arg Gln Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn 
    850                 855                 860                 


Ala Ile Leu Gly Glu Val Asn Asn Leu Ile Asp Thr Met Gln Leu Gln 
865                 870                 875                 880 


Val Ala Ser Ala Leu Ile Gln Gly Val Thr Leu Ser Ser Arg Leu Ala 
                885                 890                 895     


Asp Gly Ile Gly Gly Gln Ile Asp Asp Ile Asn Phe Ser Pro Leu Leu 
            900                 905                 910         


Gly Cys Leu Gly Ser Asp Cys Gly Glu Gly Thr Thr Ala Ala Leu Lys 
        915                 920                 925             


Gly Arg Ser Val Ile Glu Asp Met Leu Phe Asp Lys Val Lys Leu Ser 
    930                 935                 940                 


Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys Thr Gly Gly Gln Glu 
945                 950                 955                 960 


Val Arg Asp Leu Leu Cys Val Gln Ser Phe Asn Gly Ile Lys Val Leu 
                965                 970                 975     


Pro Pro Val Leu Ser Glu Ser Gln Ile Ser Gly Tyr Thr Ala Gly Ala 
            980                 985                 990         


Thr Ala Ser Ala Met Phe Pro Pro  Trp Ser Ala Ala Ala  Gly Val Pro 
        995                 1000                 1005             


Phe Ser  Leu Ser Val Gln Tyr  Arg Ile Asn Gly Leu  Gly Val Thr 
    1010                 1015                 1020             


Met Asn  Val Leu Ser Glu Asn  Gln Lys Met Ile Ala  Ser Ala Phe 
    1025                 1030                 1035             


Asn Asn  Ala Ile Gly Ala Ile  Gln Glu Gly Phe Asp  Ala Thr Asn 
    1040                 1045                 1050             


Ser Ala  Leu Ala Lys Ile Gln  Ser Val Val Asn Ala  Asn Ala Glu 
    1055                 1060                 1065             


Ala Leu  Asn Asn Leu Leu Gln  Gln Leu Ser Asn Arg  Phe Gly Ala 
    1070                 1075                 1080             


Ile Ser  Ala Ser Leu Gln Glu  Ile Leu Ser Arg Leu  Asp Ala Leu 
    1085                 1090                 1095             


Glu Ala  Gln Ala Gln Ile Asp  Arg Leu Ile Asn Gly  Arg Leu Thr 
    1100                 1105                 1110             


Ala Leu  Asn Ala Tyr Val Ser  Lys Gln Leu Ser Asp  Met Thr Leu 
    1115                 1120                 1125             


Val Lys  Val Ser Ala Ala Gln  Ala Ile Glu Lys Val  Asn Glu Cys 
    1130                 1135                 1140             


Val Lys  Ser Gln Ser Pro Arg  Ile Asn Phe Cys Gly  Asn Gly Asn 
    1145                 1150                 1155             


His Ile  Leu Ser Leu Val Gln  Ser Ala Pro Tyr Gly  Leu Tyr Phe 
    1160                 1165                 1170             


Ile His  Phe Ser Tyr Val Pro  Thr Ser Phe Thr Thr  Val Asn Val 
    1175                 1180                 1185             


Ser Pro  Gly Leu Cys Ile Ser  Gly Asp Arg Gly Leu  Ala Pro Lys 
    1190                 1195                 1200             


Ala Gly  Tyr Phe Val Gln Asp  Asn Gly Glu Trp Lys  Phe Thr Gly 
    1205                 1210                 1215             


Ser Gly  Tyr Tyr Tyr Pro Glu  Pro Ile Asn Asp Lys  Asn Ser Val 
    1220                 1225                 1230             


Val Met  Ser Ser Cys Ala Val  Asn Tyr Thr Lys Ala  Pro Glu Val 
    1235                 1240                 1245             


Phe Leu  Asn Thr Ser Ile Pro  Asn Leu Pro Asp Phe  Lys Glu Glu 
    1250                 1255                 1260             


Leu Asp  Lys Trp Phe Lys Asn  Gln Thr Ser Ile Ala  Pro Asp Leu 
    1265                 1270                 1275             


Ser Leu  Asp Phe Glu Lys Leu  Asn Val Thr Phe Leu  Asp Leu Thr 
    1280                 1285                 1290             


Asp Glu  Met Asn Arg Ile Gln  Glu Ser Ile Lys Lys  Leu Asn Glu 
    1295                 1300                 1305             


Ser Tyr  Ile Asn Leu Lys Glu  Val Gly Thr Tyr Glu  Met Tyr Val 
    1310                 1315                 1320             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Leu Ile Gly Leu  Ala Gly Val 
    1325                 1330                 1335             


Ala Val  Cys Val Leu Leu Phe  Phe Ile Cys Cys Cys  Thr Gly Cys 
    1340                 1345                 1350             


Gly Ser  Cys Cys Phe Lys Lys  Cys Gly Asn Cys Cys  Asp Glu Tyr 
    1355                 1360                 1365             


Gly Gly  His Gln Asp Ser Ile  Val Ile His Asn Ile  Ser Ser His 
    1370                 1375                 1380             


Glu Asp  Gly Ser Ser Arg Val  Asp 
    1385                 1390     


<210>  84
<211>  3909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS CoV 2 S Gene

<400>  84
gaattctgaa tgaaatatac aagttatatc ttggcttttc agctctgcat cgttttgggt       60

tctcttggca tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat      120

cttacaacca gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat      180

taccctgaca aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct      240

ttcttttcca atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag      300

aggtttgata accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag      360

tctaacataa taagaggctg gatttttggt actactttag attcgaagac ccagtcccta      420

cttattgtta ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat      480

gatccatttt tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc      540

agagtttatt ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg      600

gaccttgaag gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt      660

gatggttatt ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct      720

cagggttttt cggctttaga accattggta gatttgccaa taggtattaa catcactagg      780

tttcaaactt tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt      840

tggacagctg gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta      900

aaatataatg aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca      960

gaaacaaagt gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac     1020

tttagagtcc aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct     1080

tttggtgaag tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga     1140

atcagcaact gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt     1200

aagtgttatg gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca     1260

gattcatttg taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag     1320

attgctgatt ataattataa attaccagat gattttacag gctgcgttat agcttggaac     1380

tctaacaatc ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg     1440

aagtctaatc tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc     1500

acaccttgta atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc     1560

caacccacta atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt     1620

ctacatgcac cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa     1680

tgtgtcaatt tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa     1740

aagtttctgc ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt     1800

gatccacaga cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt     1860

ataacaccag gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc     1920

acagaagtcc ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct     1980

acaggttcta atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac     2040

aactcatatg agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag     2100

actaattctc ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg     2160

tcacttggtg cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat     2220

tttactatta gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat     2280

tgtacaatgt acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc     2340

agtttttgta cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac     2400

acccaagaag tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt     2460

ggtggtttta atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt     2520

attgaagatc tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat     2580

ggtgattgcc ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc     2640

cttactgttt tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg     2700

ttagcgggta caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca     2760

tttgctatgc aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat     2820

gagaaccaaa aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca     2880

ctttcttcca cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa     2940

gctttaaaca cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta     3000

aatgatatcc tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc     3060

acaggcagac ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa     3120

atcagagctt ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca     3180

aaaagagttg atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct     3240

catggtgtag tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact     3300

gctcctgcca tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca     3360

aatggcacac actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca     3420

gacaacacat ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt     3480

tatgatcctt tgcaacctga attagactca ttcaaggagg agttagataa atattttaag     3540

aatcatacat caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta     3600

aacattcaaa aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc     3660

atcgatctcc aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg     3720

ctaggtttta tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg     3780

accagttgct gtagttgtct caagggctgt tgttcttgtg gatcctgctg caaatttgat     3840

gaagacgact ctgagccagt gctcaaagga gtcaaattac attacacata aggatcctct     3900

agagtcgac                                                             3909


<210>  85
<211>  1301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS CoV 2 S Gene

<400>  85

Glu Phe Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile 
1               5                   10                  15      


Val Leu Gly Ser Leu Gly Met Phe Val Phe Leu Val Leu Leu Pro Leu 
            20                  25                  30          


Val Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
        35                  40                  45              


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
    50                  55                  60                  


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
65                  70                  75                  80  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
                85                  90                  95      


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
            100                 105                 110         


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
        115                 120                 125             


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
    130                 135                 140                 


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
145                 150                 155                 160 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
                165                 170                 175     


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
            180                 185                 190         


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
        195                 200                 205             


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
    210                 215                 220                 


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
225                 230                 235                 240 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
                245                 250                 255     


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
            260                 265                 270         


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
        275                 280                 285             


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
    290                 295                 300                 


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
305                 310                 315                 320 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
                325                 330                 335     


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
            340                 345                 350         


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
        355                 360                 365             


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
    370                 375                 380                 


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
385                 390                 395                 400 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
                405                 410                 415     


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            420                 425                 430         


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
        435                 440                 445             


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
    450                 455                 460                 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
465                 470                 475                 480 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
                485                 490                 495     


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
            500                 505                 510         


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
        515                 520                 525             


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
    530                 535                 540                 


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
545                 550                 555                 560 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
                565                 570                 575     


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
            580                 585                 590         


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
        595                 600                 605             


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
    610                 615                 620                 


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
625                 630                 635                 640 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
                645                 650                 655     


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
            660                 665                 670         


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
        675                 680                 685             


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg 
    690                 695                 700                 


Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
705                 710                 715                 720 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
                725                 730                 735     


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
            740                 745                 750         


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
        755                 760                 765             


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
    770                 775                 780                 


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
785                 790                 795                 800 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
                805                 810                 815     


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
            820                 825                 830         


Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
        835                 840                 845             


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
    850                 855                 860                 


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
865                 870                 875                 880 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
                885                 890                 895     


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
            900                 905                 910         


Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
        915                 920                 925             


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
    930                 935                 940                 


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
945                 950                 955                 960 


Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
                965                 970                 975     


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
            980                 985                 990         


Gly Ala Ile Ser Ser Val Leu Asn  Asp Ile Leu Ser Arg  Leu Asp Lys 
        995                 1000                 1005             


Val Glu  Ala Glu Val Gln Ile  Asp Arg Leu Ile Thr  Gly Arg Leu 
    1010                 1015                 1020             


Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln Leu Ile  Arg Ala Ala 
    1025                 1030                 1035             


Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu 
    1040                 1045                 1050             


Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly 
    1055                 1060                 1065             


Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala Pro His  Gly Val Val 
    1070                 1075                 1080             


Phe Leu  His Val Thr Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr 
    1085                 1090                 1095             


Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys Ala His  Phe Pro Arg 
    1100                 1105                 1110             


Glu Gly  Val Phe Val Ser Asn  Gly Thr His Trp Phe  Val Thr Gln 
    1115                 1120                 1125             


Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe 
    1130                 1135                 1140             


Val Ser  Gly Asn Cys Asp Val  Val Ile Gly Ile Val  Asn Asn Thr 
    1145                 1150                 1155             


Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu 
    1160                 1165                 1170             


Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser Pro Asp  Val Asp Leu 
    1175                 1180                 1185             


Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys 
    1190                 1195                 1200             


Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser 
    1205                 1210                 1215             


Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys 
    1220                 1225                 1230             


Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile Ala Gly  Leu Ile Ala 
    1235                 1240                 1245             


Ile Val  Met Val Thr Ile Met  Leu Cys Cys Met Thr  Ser Cys Cys 
    1250                 1255                 1260             


Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly Ser Cys  Cys Lys Phe 
    1265                 1270                 1275             


Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys Gly Val  Lys Leu His 
    1280                 1285                 1290             


Tyr Thr  Gly Ser Ser Arg Val  Asp 
    1295                 1300     


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RGD4C-targeting peptide

<400>  86

Cys Asp Cys Arg Gly Asp Cys Phe Cys 
1               5                   


<210>  87
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  87
agctttgcct gtccgttcgg cgaagtgttc aacgcgaccc gcttcgcgag cgtgtatgcg       60

tggaaccgca aacgcatcag caactgtcct gca                                    93


<210>  88
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  88
ggacagttgc tgatgcgttt gcggttccac gcatacacgc tcgcgaagcg ggtcgcgttg       60

aacacttcgc cgaacggaca ggcaa                                             85


<210>  89
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  89
agctttgcct gttatggcgt gagcccgacc aaactgaacg atctgtgtcc tgca             54


<210>  90
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  90
ggacacagat cgttcagttt ggtcgggctc acgccataac aggcaa                      46


<210>  91
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  91
agctttgcct gtaacggcgt ggaaggcttc aactgtcctg ca                          42


<210>  92
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  92
ggacagttga agccttccac gccgttacag gcaa                                   34


<210>  93
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  93
agctttgcct gtgatatccc gatcggcgcg ggcatctgtc ctgca                       45


<210>  94
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  94
ggacagatgc ccgcgccgat cgggatatca caggcaa                                37


<210>  95
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  95
agctttgcct gtaccatgta tatctgtggc gatagcaccg aatgtag                     47


<210>  96
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  96
caacctgctg ctgcagtatg gcagcttctg tcctgca                                37


<210>  97
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  97
ggacagaaga tcgccacaga tatacatggt acaggcaa                               38


<210>  98
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  98
agctttgcct gtgtgctggg ccagagcaaa cgcgtggatt tctgtcc                     47


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  99
gtggatagcg gtttgactca c                                                 21


<210>  100
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  100
tggtcccaga gacatgtata gcatgg                                            26


<210>  101
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  101
agggctgttg ttcttgtgga tcc                                               23


<210>  102
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  102
ggacacctag tcagacaaaa tgatgc                                            26


<210>  103
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  103
agcaagctga taaaccgata caatt                                             25


<210>  104
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  104
ccctcatagt tagcgtaacg atct                                              24


<210>  105
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  105

Thr Gly Ala Gly Gly Thr Gly Gly Thr Ala Thr Cys Gly Gly Cys Ala 
1               5                   10                  15      


Ala Thr Gly Ala 
            20  


<210>  106
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  106

Gly Gly Ala Thr Gly Cys Thr Gly Thr Ala Thr Thr Thr Ala Gly Gly 
1               5                   10                  15      


Cys Cys Gly Thr Thr Thr 
            20          


<210>  107
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  107

Thr Gly Cys Cys Gly Cys Gly Ala Cys Ala Gly Cys Cys 
1               5                   10              


<210>  108
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  108

Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg 
1               5                   10                  15      


Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  


<210>  109
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  109

Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
1               5                   10                  15      


Glu Gly Lys 
            


<210>  110
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  110

His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
1               5                   10                  15      


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
            20                  25                  30          


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
        35                  40                  45              


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
    50                  55                  60                  


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
65                  70                  75                  80  


Asp 
    


<210>  111
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 209-226)

<400>  111

Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
1               5                   10                  15      


Pro Leu 
        


<210>  112
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  112

Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
1               5                   10                  15      


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
            20                  25                  30          


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
        35                  40                  45              


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
    50                  55                  60                  


Phe Thr Asn Val Tyr 
65                  


<210>  113
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  113

Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
1               5                   10                  15      


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            20                  25                  30          


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        35                  40                  45              


Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    50                  55                  60                  


Asp Ile Ser Thr Glu 
65                  


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  114

Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
1               5                   10  


<210>  115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  115

Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
1               5                   10      


<210>  116
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  116

Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
1               5                   10          


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  117

Asn Leu Lys Pro Phe Glu Arg Asp 
1               5               


<210>  118
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  118

Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
1               5                   10                  15      


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
            20                  25                  30          


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
        35                  40                  45              


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  119

Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
1               5                   10  


<210>  120
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 495-521)

<400>  120

Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
1               5                   10                  15      


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
            20                  25          


<210>  121
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  121

Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
1               5                   10                  15      


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            20                  25                  30          


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        35                  40                  45              


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    50                  55                  60                  


<210>  122
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  122

Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
1               5                   10                  15      


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
            20                  25                  30          


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
        35                  40                  45              


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
    50                  55                  60                  


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
65                  70                  75                  80  


Asn Ser Val Ala Tyr 
                85  


<210>  123
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  123

Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu 
1               5                   10                  15      


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly 
            20                  25                  30          


Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val 
        35                  40                  45              


Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn 
    50                  55                  60                  


Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe 
65                  70                  75                  80  


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
                85                  90                  95  


<210>  124
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 769-786)

<400>  124

Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
1               5                   10                  15      


Val Lys 
        


<210>  125
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  125

Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
            20                  25                  30          


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
        35                  40                  45              


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
    50                  55                  60                  


Asn 
65  


<210>  126
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 902-926)

<400>  126

Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr 
1               5                   10                  15      


Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            20                  25  


<210>  127
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Figure 10

<400>  127

Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys 
1               5                   10                  15      


Asn His Thr Ser Pro Asp Val Asp 
            20                  


<210>  128
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGN

<400>  128
cgaattggga tccgagcatc gattgaattc tgaatgaaat atacaagtta tatcttggct       60

tttcagctct gcatcgtttt gggttctctt ggctgaggat cctctagagt cgacctgcag      120

aagcttgcct cgat                                                        134


<210>  129
<211>  134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGN

<400>  129
gcttaaccct aggctcgtag ctaacttaag acttacttta tatgttcaat atagaaccga       60

aaagtcgaga cgtagcaaaa cccaagagaa ccgactccta ggagatctca gctggacgtc      120

ttcgaacgga gcta                                                        134


<210>  130
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  130
cgaattggga tccgagcatc g                                                 21


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  131
atcgaggcaa gcttctgcag                                                   20


<210>  132
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  132
gcttttcagc tctgcatcgt t                                                 21


<210>  133
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  133
gactagtggc aataaaacaa gaaaaaca                                          28


<210>  134
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  134
tgggttctct tggcatgt                                                     18


<210>  135
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 764-829)

<400>  135

Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
1               5                   10                  15      


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
            20                  25                  30          


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
        35                  40                  45              


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
    50                  55                  60                  


Leu Ala 
65      


<210>  136
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S protein epitope (aa 405-469)

<400>  136

Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
1               5                   10                  15      


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
            20                  25                  30          


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
        35                  40                  45              


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
    50                  55                  60                  


Ser 
65  


