                               SEQUENCE LISTING

<110> KIROMIC BIOPHARMA, INC.
 
<120> MESOTHELIN ISOFORM BINDING MOLECULES AND CHIMERIC PD1 RECEPTOR 
      MOLECULES, CELLS CONTAINING THE SAME AND USES THEREOF

<130> PA-3318/017

<140> PCT/US2021/040348
<141> 2021-07-02

<150> 63/185,790
<151> 2021-05-07

<150> 63/115,465
<151> 2020-11-18

<150> 63/048,488
<151> 2020-07-06

<160> 216   

<170> PatentIn version 3.5

<210> 1
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Ala Met Ser Trp Val Arg His Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Ala Trp Val Ala Ser Ile Thr Phe Gly Gly Asp Pro Tyr Tyr Pro Asp 
65                  70                  75                  80  


Gly Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Arg Asn Ile 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Arg His Glu Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala 
    130                 


<210> 2
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg His Thr Pro Glu Lys Arg Leu Ala Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Phe Gly Gly Asp Pro Tyr Tyr Pro Asp Gly Leu Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Val 
                85                  90                  95      


Arg His Glu Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Arg Tyr Ala Met Ser 
1               5   


<210> 4
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Ser Ile Thr Phe Gly Gly Asp Pro Tyr Tyr Pro Asp Gly Leu Lys Gly 
1               5                   10                  15      


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
His Glu Ser Trp Phe Ala Tyr 
1               5           


<210> 6
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210> 7
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Trp Val Arg His Thr Pro Glu Lys Arg Leu Ala Trp Val Ala 
1               5                   10                  


<210> 8
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Arg Phe Thr Ile Ser Arg Asp Asn Thr Arg Asn Ile Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210> 10
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Glu Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile 
        35                  40                  45              


Val His Thr Asp Gly Asn Ile Tyr Leu Glu Trp Tyr Leu Gln Asn Pro 
    50                  55                  60                  


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Ala Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210> 11
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Thr 
            20                  25                  30          


Asp Gly Asn Ile Tyr Leu Glu Trp Tyr Leu Gln Asn Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 12
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Arg Ser Ser Gln Thr Ile Val His Thr Asp Gly Asn Ile Tyr Leu Glu 
1               5                   10                  15      


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Lys Ile Ser Asn Arg Phe Ser 
1               5           


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Phe Gln Ala Ser His Val Pro Tyr Thr 
1               5                   


<210> 15
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Gln Val Ser Ile Ser Cys 
            20              


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Trp Tyr Leu Gln Asn Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 17
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys 
            20                  25                  30          


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210> 19
<211> 402
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
atgaacttcg ggttcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgaagctgg tggagtctgg gggaggctta gtgaagcctg gggggtccct gaaactctcc      120

tgtgaggcct ctgggttcac tttcagtcgc tatgccatgt cttgggttcg ccatactcca      180

gagaagagac tggcctgggt cgcatccata acttttggtg gtgacccgta ttatcccgac      240

ggtttgaagg gccgattcac catctccaga gataatacca ggaacatcct gtacctgcaa      300

atgaacagtc tgaggtctga agacacggcc atgtattatt gtgtacgaca cgagtcatgg      360

tttgcttact ggggccaagg gactctggtc actgtctctg ca                         402


<210> 20
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggggggtc cctgaaactc       60

tcctgtgagg cctctgggtt cactttcagt cgctatgcca tgtcttgggt tcgccatact      120

ccagagaaga gactggcctg ggtcgcatcc ataacttttg gtggtgaccc gtattatccc      180

gacggtttga agggccgatt caccatctcc agagataata ccaggaacat cctgtacctg      240

caaatgaaca gtctgaggtc tgaagacacg gccatgtatt attgtgtacg acacgagtca      300

tggtttgctt actggggcca agggactctg gtcactgtct ctgca                      345


<210> 21
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
cgctatgcca tgtct                                                        15


<210> 22
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
tccataactt ttggtggtga cccgtattat cccgacggtt tgaagggc                    48


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
cacgagtcat ggtttgctta c                                                 21


<210> 24
<211> 90
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggggggtc cctgaaactc       60

tcctgtgagg cctctgggtt cactttcagt                                        90


<210> 25
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 25
tgggttcgcc atactccaga gaagagactg gcctgggtcg ca                          42


<210> 26
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 26
cgattcacca tctccagaga taataccagg aacatcctgt acctgcaaat gaacagtctg       60

aggtctgaag acacggccat gtattattgt gtacga                                 96


<210> 27
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
tggggccaag ggactctggt cactgtctct gca                                    33


<210> 28
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 28
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagaaca agtctccatc      120

tcttgcagat ctagtcagac cattgtacat actgatggca acatctattt agaatggtac      180

ctccagaacc caggccagtc tcctaggctc ctgatctaca aaatttccaa ccgattttct      240

ggggtccctg acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggaatttat tactgctttc aagcttcaca tgttccgtac      360

acgttcggag gggggaccaa gctggaaata aaa                                   393


<210> 29
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 29
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga acaagtctcc       60

atctcttgca gatctagtca gaccattgta catactgatg gcaacatcta tttagaatgg      120

tacctccaga acccaggcca gtctcctagg ctcctgatct acaaaatttc caaccgattt      180

tctggggtcc ctgacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tattactgct ttcaagcttc acatgttccg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210> 30
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
agatctagtc agaccattgt acatactgat ggcaacatct atttagaa                    48


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
aaaatttcca accgattttc t                                                 21


<210> 32
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
tttcaagctt cacatgttcc gtacacg                                           27


<210> 33
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga acaagtctcc       60

atctcttgc                                                               69


<210> 34
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
tggtacctcc agaacccagg ccagtctcct aggctcctga tctac                       45


<210> 35
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
ggggtccctg acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggaatttat tactgc                                 96


<210> 36
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
ttcggagggg ggaccaagct ggaaataaaa                                        30


<210> 37
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Val Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Thr Phe Gly Gly Ser Ala Tyr Tyr Leu Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ile 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Val Ser Glu Asp Thr Ala Ile Tyr 
            100                 105                 110         


Asn Cys Ala Arg His Gln Pro Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala 
    130                 


<210> 38
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Phe Gly Gly Ser Ala Tyr Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Val Ser Glu Asp Thr Ala Ile Tyr Asn Cys Ala 
                85                  90                  95      


Arg His Gln Pro Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210> 39
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Arg Tyr Ala Met Ser 
1               5   


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Ser Ile Thr Phe Gly Gly Ser Ala Tyr Tyr Leu Asp Ser Val Lys Gly 
1               5                   10                  15      


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
His Gln Pro Trp Phe Asp Tyr 
1               5           


<210> 42
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210> 43
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210> 44
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ile Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Val Ser Glu Asp Thr Ala Ile Tyr Asn Cys Ala Arg 
            20                  25                  30          


<210> 45
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210> 46
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (49)..(49)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(131)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 46
Met Asn Leu Pro Ile Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile 
        35                  40                  45              


Ile His Ser Asp Gly Asp Thr Tyr Leu Asp Trp Phe Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Ala Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Val Lys 
    130     


<210> 47
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (30)..(30)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(112)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 47
Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Ile His Ser 
            20                  25                  30          


Asp Gly Asp Thr Tyr Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Val Lys 
            100                 105                 110         


<210> 48
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 48
Arg Ser Ser Gln Asn Ile Ile His Ser Asp Gly Asp Thr Tyr Leu Asp 
1               5                   10                  15      


<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Lys Val Ser Asn Arg Phe Ser 
1               5           


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Phe Gln Ala Ser His Val Pro Tyr Thr 
1               5                   


<210> 51
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210> 52
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Trp Phe Leu Gln Lys Pro Gly Gln Ser Pro Asn Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 53
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210> 54
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Phe Gly Gly Gly Thr Lys Leu Glu Val Lys 
1               5                   10  


<210> 55
<211> 402
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 55
atgaacttcg ggttcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgcgaa       60

gtgaagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaagtctcc      120

tgtacagcct ctggattcac tttcagtcgt tatgccatgt cttgggttcg ccagactcca      180

gagaggaggc tggagtgggt cgcatccatt acttttggtg gtagcgccta ctatttagac      240

agtgtgaagg gccgattcac catctccaga gataatgccc agaacatcct gtacctgcaa      300

atgaacagtc tggtgtctga ggacacggcc atttataact gtgcaagaca ccagccctgg      360

tttgattact ggggccaagg gactctggtc actgtctctg ca                         402


<210> 56
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 56
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaagtc       60

tcctgtacag cctctggatt cactttcagt cgttatgcca tgtcttgggt tcgccagact      120

ccagagagga ggctggagtg ggtcgcatcc attacttttg gtggtagcgc ctactattta      180

gacagtgtga agggccgatt caccatctcc agagataatg cccagaacat cctgtacctg      240

caaatgaaca gtctggtgtc tgaggacacg gccatttata actgtgcaag acaccagccc      300

tggtttgatt actggggcca agggactctg gtcactgtct ctgca                      345


<210> 57
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 57
cgttatgcca tgtct                                                        15


<210> 58
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 58
tccattactt ttggtggtag cgcctactat ttagacagtg tgaagggc                    48


<210> 59
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 59
caccagccct ggtttgatta c                                                 21


<210> 60
<211> 90
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 60
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaagtc       60

tcctgtacag cctctggatt cactttcagt                                        90


<210> 61
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 61
tgggttcgcc agactccaga gaggaggctg gagtgggtcg ca                          42


<210> 62
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 62
cgattcacca tctccagaga taatgcccag aacatcctgt acctgcaaat gaacagtctg       60

gtgtctgagg acacggccat ttataactgt gcaaga                                 96


<210> 63
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 63
tggggccaag ggactctggt cactgtctct gca                                    33


<210> 64
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 64
atgaacttgc ctattaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gtcttgctga cccagactcc actctccctg cctgtcagtc ttggagatca ggcctccatc      120

tcttgcagat ctagtcagaa cattrtwcat agtgatggag acacctattt agactggttc      180

ctgcagaaac caggccagtc tccaaacctc ctaatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcaccct caagatcagc      300

agagtggagg ctgacgatct gggagtttat tactgctttc aagcttcaca tgttccgtac      360

acgttcggag gggggaccaa gctggaagta aaa                                   393


<210> 65
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 65
gatgtcttgc tgacccagac tccactctcc ctgcctgtca gtcttggaga tcaggcctcc       60

atctcttgca gatctagtca gaacattrtw catagtgatg gagacaccta tttagactgg      120

ttcctgcaga aaccaggcca gtctccaaac ctcctaatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac cctcaagatc      240

agcagagtgg aggctgacga tctgggagtt tattactgct ttcaagcttc acatgttccg      300

tacacgttcg gaggggggac caagctggaa gtaaaa                                336


<210> 66
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 66
agatctagtc agaacattrt wcatagtgat ggagacacct atttagac                    48


<210> 67
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 67
aaagtttcca accgattttc t                                                 21


<210> 68
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 68
tttcaagctt cacatgttcc gtacacg                                           27


<210> 69
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 69
gatgtcttgc tgacccagac tccactctcc ctgcctgtca gtcttggaga tcaggcctcc       60

atctcttgc                                                               69


<210> 70
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 70
tggttcctgc agaaaccagg ccagtctcca aacctcctaa tctac                       45


<210> 71
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 71
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcaccct caagatcagc       60

agagtggagg ctgacgatct gggagtttat tactgc                                 96


<210> 72
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 72
ttcggagggg ggaccaagct ggaagtaaaa                                        30


<210> 73
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 73
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser 
            20                  25                  30          


Asn Val Ser Thr Asn Val Ser Ser Pro Glu Val Lys Leu Val Glu Ser 
        35                  40                  45              


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu 
    50                  55                  60                  


Ala Ser Gly Phe Thr Phe Ser Arg Tyr Ala Met Ser Trp Val Arg His 
65                  70                  75                  80  


Thr Pro Glu Lys Arg Leu Ala Trp Val Ala Ser Ile Thr Phe Gly Gly 
                85                  90                  95      


Asp Pro Tyr Tyr Pro Asp Gly Leu Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Thr Arg Asn Ile Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser 
        115                 120                 125             


Glu Asp Thr Ala Met Tyr Tyr Cys Val Arg His Glu Ser Trp Phe Ala 
    130                 135                 140                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Leu Met Thr 
                165                 170                 175     


Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Glu Gln Val Ser Ile 
            180                 185                 190         


Ser Cys Arg Ser Ser Gln Thr Ile Val His Thr Asp Gly Asn Ile Tyr 
        195                 200                 205             


Leu Glu Trp Tyr Leu Gln Asn Pro Gly Gln Ser Pro Arg Leu Leu Ile 
    210                 215                 220                 


Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                245                 250                 255     


Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Ala Ser His Val Pro Tyr 
            260                 265                 270         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro 
        275                 280                 285             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    290                 295                 300                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
305                 310                 315                 320 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            340                 345                 350         


Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Val Asp 
        355                 360                 365             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    370                 375                 380                 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
385                 390                 395                 400 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520     


<210> 74
<211> 1563
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 74
atggctcttc cggtaaccgc tctgctgctt cctttggctc tgcttcttca cgcggctagg       60

ccagggagcg aattgcctac gcaggggact ttttcaaatg taagcacgaa tgtgagctct      120

ccggaagtga aattggtaga gtctggtggg ggactggtta aacctggagg cagtctgaag      180

ctctcctgcg aagccagcgg ctttacgttc agtcggtacg ctatgtcctg ggtgcgacac      240

acaccagaaa agcgactcgc ttgggtagcg agcataacgt ttgggggcga tccttattac      300

ccggatggtt tgaaaggtcg cttcactatc agtcgagata atacgcgaaa cattctttat      360

cttcaaatga atagcctgcg ctctgaagac accgcgatgt attattgtgt taggcatgag      420

tcttggtttg catactgggg tcagggtact cttgtcactg tatctgccgg aggtgggggt      480

agcggcggcg gaggtagtgg gggaggcggc agcgacgtgt tgatgactca aactccgctt      540

agcttgccag tgtctcttgg agaacaggtc tccatatcat gtcgatccag tcaaactatc      600

gttcataccg atgggaatat ctatctcgaa tggtatctgc aaaatccagg gcagagtccc      660

cggcttctga tatataagat tagcaataga tttagtggtg ttcccgacag gttttcaggt      720

tctgggtccg gaacggattt taccctgaag ataagtcgag ttgaagcgga agacctgggc      780

atatactatt gcttccaggc gtcccacgtc ccctatacat ttgggggtgg gactaaactg      840

gaaattaaac gtacgacgac accagcccca agacccccaa ctcccgctcc taccatagct      900

tcccaacccc tgtcactgag gccagaggca tgcaggcccg ctgcgggtgg cgcggtacat      960

acgcggggac tggactttgc atgtgacatt tacatatggg cgccactggc gggaacatgt     1020

ggagttttgt tgcttagcct ggtcataaca ctgtattgca atcatcgcaa cagacgccgc     1080

gtctgcaagt gtcccagggt cgacagatct aagagaagta gacttcttca cagtgattat     1140

atgaatatga cgcctcgaag acccggcccg acacgcaaac actatcagcc gtatgccccc     1200

cctcgggatt ttgctgccta ccgcagccgc gttaagttct ctaggtccgc tgacgcccct     1260

gcctaccagc agggtcaaaa ccaactgtac aatgaattga atcttgggag acgggaggag     1320

tatgacgtac tcgacaagcg gagggggaga gatcctgaga tgggtggaaa gcctcgacga     1380

aaaaacccac aagaagggtt gtataatgaa ctgcagaaag acaagatggc tgaggcatat     1440

agtgaaatcg ggatgaaggg agaacgccgg cgcgggaaag ggcacgatgg tctgtatcaa     1500

gggcttagta cggctacgaa ggacacatat gacgctttgc acatgcaggc ccttcctcct     1560

agg                                                                   1563


<210> 75
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 76
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
atggctcttc cggtaaccgc tctgctgctt cctttggctc tgcttcttca cgcggctagg       60

cca                                                                     63


<210> 77
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Gly Ser 
1       


<210> 78
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 78
gggagc                                                                   6


<210> 79
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


<210> 80
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 80
gaattgccta cgcaggggac tttttcaaat gtaagcacga atgtgagc                    48


<210> 81
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 81
Ser Pro 
1       


<210> 82
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 82
tctccg                                                                   6


<210> 83
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 83
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg His Thr Pro Glu Lys Arg Leu Ala Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Phe Gly Gly Asp Pro Tyr Tyr Pro Asp Gly Leu Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Val 
                85                  90                  95      


Arg His Glu Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210> 84
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 84
gaagtgaaat tggtagagtc tggtggggga ctggttaaac ctggaggcag tctgaagctc       60

tcctgcgaag ccagcggctt tacgttcagt cggtacgcta tgtcctgggt gcgacacaca      120

ccagaaaagc gactcgcttg ggtagcgagc ataacgtttg ggggcgatcc ttattacccg      180

gatggtttga aaggtcgctt cactatcagt cgagataata cgcgaaacat tctttatctt      240

caaatgaata gcctgcgctc tgaagacacc gcgatgtatt attgtgttag gcatgagtct      300

tggtttgcat actggggtca gggtactctt gtcactgtat ctgcc                      345


<210> 85
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 85
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 86
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 86
ggaggtgggg gtagcggcgg cggaggtagt gggggaggcg gcagc                       45


<210> 87
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 87
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Thr 
            20                  25                  30          


Asp Gly Asn Ile Tyr Leu Glu Trp Tyr Leu Gln Asn Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 88
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 88
gacgtgttga tgactcaaac tccgcttagc ttgccagtgt ctcttggaga acaggtctcc       60

atatcatgtc gatccagtca aactatcgtt cataccgatg ggaatatcta tctcgaatgg      120

tatctgcaaa atccagggca gagtccccgg cttctgatat ataagattag caatagattt      180

agtggtgttc ccgacaggtt ttcaggttct gggtccggaa cggattttac cctgaagata      240

agtcgagttg aagcggaaga cctgggcata tactattgct tccaggcgtc ccacgtcccc      300

tatacatttg ggggtgggac taaactggaa attaaa                                336


<210> 89
<211> 1
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 89
Arg 
1   


<210> 90
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 90
cgt                                                                      3


<210> 91
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 91
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 92
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 92
acgacgacac cagccccaag acccccaact cccgctccta ccatagcttc ccaacccctg       60

tcactgaggc cagaggcatg caggcccgct gcgggtggcg cggtacatac gcggggactg      120

gactttgcat gtgac                                                       135


<210> 93
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 93
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
            20                  25                  30          


Cys Lys Cys Pro Arg 
        35          


<210> 94
<211> 111
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 94
atttacatat gggcgccact ggcgggaaca tgtggagttt tgttgcttag cctggtcata       60

acactgtatt gcaatcatcg caacagacgc cgcgtctgca agtgtcccag g               111


<210> 95
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 95
Val Asp 
1       


<210> 96
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 96
gtcgac                                                                   6


<210> 97
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 97
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210> 98
<211> 123
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 98
agatctaaga gaagtagact tcttcacagt gattatatga atatgacgcc tcgaagaccc       60

ggcccgacac gcaaacacta tcagccgtat gccccccctc gggattttgc tgcctaccgc      120

agc                                                                    123


<210> 99
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 99
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 100
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 100
cgcgttaagt tctctaggtc cgctgacgcc cctgcctacc agcagggtca aaaccaactg       60

tacaatgaat tgaatcttgg gagacgggag gagtatgacg tactcgacaa gcggaggggg      120

agagatcctg agatgggtgg aaagcctcga cgaaaaaacc cacaagaagg gttgtataat      180

gaactgcaga aagacaagat ggctgaggca tatagtgaaa tcgggatgaa gggagaacgc      240

cggcgcggga aagggcacga tggtctgtat caagggctta gtacggctac gaaggacaca      300

tatgacgctt tgcacatgca ggcccttcct cctagg                                336


<210> 101
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (201)..(201)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(521)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 101
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser 
            20                  25                  30          


Asn Val Ser Thr Asn Val Ser Ser Pro Glu Val Lys Leu Val Glu Ser 
        35                  40                  45              


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Thr 
    50                  55                  60                  


Ala Ser Gly Phe Thr Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln 
65                  70                  75                  80  


Thr Pro Glu Arg Arg Leu Glu Trp Val Ala Ser Ile Thr Phe Gly Gly 
                85                  90                  95      


Ser Ala Tyr Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ala Gln Asn Ile Leu Tyr Leu Gln Met Asn Ser Leu Val Ser 
        115                 120                 125             


Glu Asp Thr Ala Ile Tyr Asn Cys Ala Arg His Gln Pro Trp Phe Asp 
    130                 135                 140                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Leu Leu Thr 
                165                 170                 175     


Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile 
            180                 185                 190         


Ser Cys Arg Ser Ser Gln Asn Ile Ile His Ser Asp Gly Asp Thr Tyr 
        195                 200                 205             


Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser Pro Asn Leu Leu Ile 
    210                 215                 220                 


Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                245                 250                 255     


Asp Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala Ser His Val Pro Tyr 
            260                 265                 270         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Val Lys Arg Thr Thr Thr Pro 
        275                 280                 285             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    290                 295                 300                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
305                 310                 315                 320 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            340                 345                 350         


Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Val Asp 
        355                 360                 365             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    370                 375                 380                 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
385                 390                 395                 400 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520     


<210> 102
<211> 1562
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 102
atggctcttc cggtaaccgc tctgctgctt cctttggctc tgcttcttca cgcggctagg       60

ccagggagcg aattgcctac gcaggggact ttttcaaatg taagcacgaa tgtgagctct      120

ccgaagtcaa attggtggag agtggcggtg ggctcgtaaa accaggaggc agcttgaaag      180

taagttgcac agcgtctggg ttcactttca gccgatacgc tatgagttgg gtgcggcaaa      240

cgcccgaaag acgattggag tgggtagcta gtattacttt tgggggttcc gcgtattact      300

tggatagcgt taaagggaga ttcaccatat cacgagataa tgcccaaaac atactctacc      360

tccagatgaa ctcattggtg tctgaagata ctgcaattta caactgcgcc aggcaccagc      420

catggtttga ctattggggt caaggtacgt tggtcacagt ctcagccggc ggtggcggat      480

ctggaggggg aggcagtgga ggaggtggtt cagatgttct cctgacgcaa actcctttgt      540

cattgccggt aagtctgggc gaccaagcga gcatttcctg tcgcagcagc cagaacatar      600

twcatagtga tggcgacact tacttggatt ggttcctcca gaaaccgggg caatctccga      660

acctcttgat atataaggtc tcaaatcgct ttagcggggt tcccgaccgc ttttcaggtt      720

ctggctcagg taccgatttc acgctgaaaa tttctagagt agaggctgac gatctgggtg      780

tttactattg ttttcaagct tcacacgttc cttatacgtt cggagggggg actaaactgg      840

aggttaaacg tacgacgaca ccagccccaa gacccccaac tcccgctcct accatagctt      900

cccaacccct gtcactgagg ccagaggcat gcaggcccgc tgcgggtggc gcggtacata      960

cgcggggact ggactttgca tgtgacattt acatatgggc gccactggcg ggaacatgtg     1020

gagttttgtt gcttagcctg gtcataacac tgtattgcaa tcatcgcaac agacgccgcg     1080

tctgcaagtg tcccagggtc gacagatcta agagaagtag acttcttcac agtgattata     1140

tgaatatgac gcctcgaaga cccggcccga cacgcaaaca ctatcagccg tatgcccccc     1200

ctcgggattt tgctgcctac cgcagccgcg ttaagttctc taggtccgct gacgcccctg     1260

cctaccagca gggtcaaaac caactgtaca atgaattgaa tcttgggaga cgggaggagt     1320

atgacgtact cgacaagcgg agggggagag atcctgagat gggtggaaag cctcgacgaa     1380

aaaacccaca agaagggttg tataatgaac tgcagaaaga caagatggct gaggcatata     1440

gtgaaatcgg gatgaaggga gaacgccggc gcgggaaagg gcacgatggt ctgtatcaag     1500

ggcttagtac ggctacgaag gacacatatg acgctttgca catgcaggcc cttcctccta     1560

gg                                                                    1562


<210> 103
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 103
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 104
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 104
atggctcttc cggtaaccgc tctgctgctt cctttggctc tgcttcttca cgcggctagg       60

cca                                                                     63


<210> 105
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 105
Gly Ser 
1       


<210> 106
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 106
gggagc                                                                   6


<210> 107
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 107
Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


<210> 108
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 108
gaattgccta cgcaggggac tttttcaaat gtaagcacga atgtgagc                    48


<210> 109
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 109
Ser Pro 
1       


<210> 110
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 110
tctccg                                                                   6


<210> 111
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 111
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Phe Gly Gly Ser Ala Tyr Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Val Ser Glu Asp Thr Ala Ile Tyr Asn Cys Ala 
                85                  90                  95      


Arg His Gln Pro Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210> 112
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 112
gaagtcaaat tggtggagag tggcggtggg ctcgtaaaac caggaggcag cttgaaagta       60

agttgcacag cgtctgggtt cactttcagc cgatacgcta tgagttgggt gcggcaaacg      120

cccgaaagac gattggagtg ggtagctagt attacttttg ggggttccgc gtattacttg      180

gatagcgtta aagggagatt caccatatca cgagataatg cccaaaacat actctacctc      240

cagatgaact cattggtgtc tgaagatact gcaatttaca actgcgccag gcaccagcca      300

tggtttgact attggggtca aggtacgttg gtcacagtct cagcc                      345


<210> 113
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 113
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 114
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 114
ggcggtggcg gatctggagg gggaggcagt ggaggaggtg gttca                       45


<210> 115
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (30)..(30)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(112)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 115
Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Ile His Ser 
            20                  25                  30          


Asp Gly Asp Thr Tyr Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Val Lys 
            100                 105                 110         


<210> 116
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 116
gatgttctcc tgacgcaaac tcctttgtca ttgccggtaa gtctgggcga ccaagcgagc       60

atttcctgtc gcagcagcca gaacatartw catagtgatg gcgacactta cttggattgg      120

ttcctccaga aaccggggca atctccgaac ctcttgatat ataaggtctc aaatcgcttt      180

agcggggttc ccgaccgctt ttcaggttct ggctcaggta ccgatttcac gctgaaaatt      240

tctagagtag aggctgacga tctgggtgtt tactattgtt ttcaagcttc acacgttcct      300

tatacgttcg gaggggggac taaactggag gttaaa                                336


<210> 117
<211> 1
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 117
Arg 
1   


<210> 118
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 118
cgt                                                                      3


<210> 119
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 119
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 120
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 120
acgacgacac cagccccaag acccccaact cccgctccta ccatagcttc ccaacccctg       60

tcactgaggc cagaggcatg caggcccgct gcgggtggcg cggtacatac gcggggactg      120

gactttgcat gtgac                                                       135


<210> 121
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 121
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
            20                  25                  30          


Cys Lys Cys Pro Arg 
        35          


<210> 122
<211> 111
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 122
atttacatat gggcgccact ggcgggaaca tgtggagttt tgttgcttag cctggtcata       60

acactgtatt gcaatcatcg caacagacgc cgcgtctgca agtgtcccag g               111


<210> 123
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 123
Val Asp 
1       


<210> 124
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 124
gtcgac                                                                   6


<210> 125
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 125
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210> 126
<211> 123
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 126
agatctaaga gaagtagact tcttcacagt gattatatga atatgacgcc tcgaagaccc       60

ggcccgacac gcaaacacta tcagccgtat gccccccctc gggattttgc tgcctaccgc      120

agc                                                                    123


<210> 127
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 127
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 128
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 128
cgcgttaagt tctctaggtc cgctgacgcc cctgcctacc agcagggtca aaaccaactg       60

tacaatgaat tgaatcttgg gagacgggag gagtatgacg tactcgacaa gcggaggggg      120

agagatcctg agatgggtgg aaagcctcga cgaaaaaacc cacaagaagg gttgtataat      180

gaactgcaga aagacaagat ggctgaggca tatagtgaaa tcgggatgaa gggagaacgc      240

cggcgcggga aagggcacga tggtctgtat caagggctta gtacggctac gaaggacaca      300

tatgacgctt tgcacatgca ggcccttcct cctagg                                336


<210> 129
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 129
Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210> 130
<211> 622
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 130
Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210> 131
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 131
Pro Gln Ala Pro Arg Arg Pro Leu 
1               5               


<210> 132
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 132
Arg Pro Leu Pro Gln Val Ala Thr Leu Ile Asp Arg 
1               5                   10          


<210> 133
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 133
Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp Arg 
1               5                   10                  


<210> 134
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 134
atgcagatcc cccaggcccc ctggcccgtg gtgtgggccg tgctgcagct gggctggagg       60

cccggctgg                                                               69


<210> 135
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 135
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp 
            20              


<210> 136
<211> 441
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 136
ttcctggaca gccccgacag gccctggaac ccccccacct tcagccccgc cctgctggtg       60

gtgaccgagg gcgacaacgc caccttcacc tgcagcttca gcaacaccag cgagagcttc      120

gtgctgaact ggtacaggat gagccccagc aaccagaccg acaagctggc cgccttcccc      180

gaggacagga gccagcccgg ccaggactgc aggttcaggg tgacccagct gcccaacggc      240

agggacttcc acatgagcgt ggtgagggcc aggaggaacg acagcggcac ctacctgtgc      300

ggcgccatca gcctggcccc caaggcccag atcaaggaga gcctgagggc cgagctgagg      360

gtgaccgaga ggagggccga ggtgcccacc gcccacccca gccccagccc caggcccgcc      420

ggccagttcc agaccctggt g                                                441


<210> 137
<211> 147
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 137
Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val 
145         


<210> 138
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 138
tgccccagcc ccctgttccc cggccccagc aagccc                                 36


<210> 139
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 139
Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10          


<210> 140
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 140
ttctgggtgc tggtggtggt gggcggcgtg ctggcctgct acagcctgct ggtgaccgtg       60

gccttcatca tcttctgggt g                                                 81


<210> 141
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 141
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210> 142
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 142
ctgtgcgcca ggcccaggag gagccccgcc caggaggacg gcaaggtgta catcaacatg       60

cccggcaggg gc                                                           72


<210> 143
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 143
Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210> 144
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 144
agggtgaagt tcagcaggag cgccgacgcc cccgcctacc agcagggcca gaaccagctg       60

tacaacgagc tgaacctggg caggagggag gagtacgacg tgctggacaa gaggaggggc      120

agggaccccg agatgggcgg caagccccag aggaggaaga acccccagga gggcctgtac      180

aacgagctgc agaaggacaa gatggccgag gcctacagcg agatcggcat gaagggcgag      240

aggaggaggg gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac      300

acctacgacg ccctgcacat gcaggccctg ccccccagg                             339


<210> 145
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 145
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210> 146
<211> 1038
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 146
atgcagatcc cccaggcccc ctggcccgtg gtgtgggccg tgctgcagct gggctggagg       60

cccggctggt tcctggacag ccccgacagg ccctggaacc cccccacctt cagccccgcc      120

ctgctggtgg tgaccgaggg cgacaacgcc accttcacct gcagcttcag caacaccagc      180

gagagcttcg tgctgaactg gtacaggatg agccccagca accagaccga caagctggcc      240

gccttccccg aggacaggag ccagcccggc caggactgca ggttcagggt gacccagctg      300

cccaacggca gggacttcca catgagcgtg gtgagggcca ggaggaacga cagcggcacc      360

tacctgtgcg gcgccatcag cctggccccc aaggcccaga tcaaggagag cctgagggcc      420

gagctgaggg tgaccgagag gagggccgag gtgcccaccg cccaccccag ccccagcccc      480

aggcccgccg gccagttcca gaccctggtg tgccccagcc ccctgttccc cggccccagc      540

aagcccttct gggtgctggt ggtggtgggc ggcgtgctgg cctgctacag cctgctggtg      600

accgtggcct tcatcatctt ctgggtgctg tgcgccaggc ccaggaggag ccccgcccag      660

gaggacggca aggtgtacat caacatgccc ggcaggggca gggtgaagtt cagcaggagc      720

gccgacgccc ccgcctacca gcagggccag aaccagctgt acaacgagct gaacctgggc      780

aggagggagg agtacgacgt gctggacaag aggaggggca gggaccccga gatgggcggc      840

aagccccaga ggaggaagaa cccccaggag ggcctgtaca acgagctgca gaaggacaag      900

atggccgagg cctacagcga gatcggcatg aagggcgaga ggaggagggg caagggccac      960

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     1020

caggccctgc cccccagg                                                   1038


<210> 147
<211> 346
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 147
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Cys Pro Ser Pro Leu Phe 
                165                 170                 175     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            180                 185                 190         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        195                 200                 205             


Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys 
    210                 215                 220                 


Val Tyr Ile Asn Met Pro Gly Arg Gly Arg Val Lys Phe Ser Arg Ser 
225                 230                 235                 240 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                245                 250                 255     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            260                 265                 270         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
        275                 280                 285             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    290                 295                 300                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
305                 310                 315                 320 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                325                 330                 335     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345     


<210> 148
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 148
atggctcttc cggtaaccgc tctgctgctt cctttggctc tgcttcttca cgcggctagg       60

cca                                                                     63


<210> 149
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 149
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 150
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 150
gggagc                                                                   6


<210> 151
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 151
Gly Ser 
1       


<210> 152
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 152
gaattgccta cgcaggggac tttttcaaat gtaagcacga atgtgagc                    48


<210> 153
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 153
Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


<210> 154
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 154
tctccgggat ccccaggatg g                                                 21


<210> 155
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 155
Ser Pro Gly Ser Pro Gly Trp 
1               5           


<210> 156
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 156
ttcctggaca gcccagatcg gccctggaat ccccctacct tttcccctgc cctgctggtg       60

gtgacagagg gcgacaacgc caccttcaca tgcagctttt ccaacacctc tgagagcttc      120

gtgctgaatt ggtacagaat gtccccatct aaccagacag ataagctggc cgcatttcca      180

gaggacaggt cccagcctgg acaggattgc cgcttccggg tgacccagct gcccaatggc      240

agagactttc acatgagcgt ggtgagggcc cggagaaacg attccggcac atacctgtgc      300

ggagccatct ctctggcccc aaaggcacag atcaaggaga gcctgagggc agagctgagg      360

gtgaccgaga ggagggcaga ggtg                                             384


<210> 157
<211> 147
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 157
Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val 
145         


<210> 158
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 158
tgcccttccc cactgttccc aggaccttct aagccc                                 36


<210> 159
<211> 147
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 159
Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val 
145         


<210> 160
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 160
ttttgggtgc tggtggtggt gggaggcgtg ctggcctgct actctctgct ggtgacagtg       60

gccttcatca tcttttgggt g                                                 81


<210> 161
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 161
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210> 162
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 162
ctgtgcgccc gccctcggag aagcccagca caggaggacg gcaaggtgta tatcaatatg       60

ccaggcagag gc                                                           72


<210> 163
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 163
Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210> 164
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 164
agggtgaagt tttctcggag cgccgatgca ccagcatacc agcagggaca gaaccagctg       60

tataacgagc tgaatctggg caggcgcgag gagtacgacg tgctggataa gcggagaggc      120

agagacccag agatgggagg caagccacag aggaggaaga accctcagga gggcctgtac      180

aatgagctgc agaaggacaa gatggccgag gcctattccg agatcggcat gaagggagag      240

cggagaaggg gcaagggaca cgatggcctg taccagggcc tgtctaccgc cacaaaggac      300

acctatgatg ccctgcacat gcaggccctg ccacccagg                             339


<210> 165
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 165
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210> 166
<211> 1107
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 166
atggctcttc cggtaaccgc tctgctgctt cctttggctc tgcttcttca cgcggctagg       60

ccagggagcg aattgcctac gcaggggact ttttcaaatg taagcacgaa tgtgagctct      120

ccgggatccc caggatggtt cctggacagc ccagatcggc cctggaatcc ccctaccttt      180

tcccctgccc tgctggtggt gacagagggc gacaacgcca ccttcacatg cagcttttcc      240

aacacctctg agagcttcgt gctgaattgg tacagaatgt ccccatctaa ccagacagat      300

aagctggccg catttccaga ggacaggtcc cagcctggac aggattgccg cttccgggtg      360

acccagctgc ccaatggcag agactttcac atgagcgtgg tgagggcccg gagaaacgat      420

tccggcacat acctgtgcgg agccatctct ctggccccaa aggcacagat caaggagagc      480

ctgagggcag agctgagggt gaccgagagg agggcagagg tgcctacagc acacccaagc      540

ccttccccaa gaccagcagg acagttccag accctggtgt gcccttcccc actgttccca      600

ggaccttcta agcccttttg ggtgctggtg gtggtgggag gcgtgctggc ctgctactct      660

ctgctggtga cagtggcctt catcatcttt tgggtgctgt gcgcccgccc tcggagaagc      720

ccagcacagg aggacggcaa ggtgtatatc aatatgccag gcagaggcag ggtgaagttt      780

tctcggagcg ccgatgcacc agcataccag cagggacaga accagctgta taacgagctg      840

aatctgggca ggcgcgagga gtacgacgtg ctggataagc ggagaggcag agacccagag      900

atgggaggca agccacagag gaggaagaac cctcaggagg gcctgtacaa tgagctgcag      960

aaggacaaga tggccgaggc ctattccgag atcggcatga agggagagcg gagaaggggc     1020

aagggacacg atggcctgta ccagggcctg tctaccgcca caaaggacac ctatgatgcc     1080

ctgcacatgc aggccctgcc acccagg                                         1107


<210> 167
<211> 369
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 167
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser 
            20                  25                  30          


Asn Val Ser Thr Asn Val Ser Ser Pro Gly Ser Pro Gly Trp Phe Leu 
        35                  40                  45              


Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
    50                  55                  60                  


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
65                  70                  75                  80  


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
                85                  90                  95      


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
            100                 105                 110         


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
        115                 120                 125             


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
    130                 135                 140                 


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
145                 150                 155                 160 


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
                165                 170                 175     


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu 
            180                 185                 190         


Val Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
        195                 200                 205             


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    210                 215                 220                 


Val Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser 
225                 230                 235                 240 


Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210> 168
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (201)..(201)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(521)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 168
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser 
            20                  25                  30          


Asn Val Ser Thr Asn Val Ser Ser Pro Glu Val Lys Leu Val Glu Ser 
        35                  40                  45              


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Thr 
    50                  55                  60                  


Ala Ser Gly Phe Thr Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln 
65                  70                  75                  80  


Thr Pro Glu Arg Arg Leu Glu Trp Val Ala Ser Ile Thr Phe Gly Gly 
                85                  90                  95      


Ser Ala Tyr Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ala Gln Asn Ile Leu Tyr Leu Gln Met Asn Ser Leu Val Ser 
        115                 120                 125             


Glu Asp Thr Ala Ile Tyr Asn Cys Ala Arg His Gln Pro Trp Phe Asp 
    130                 135                 140                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Leu Leu Thr 
                165                 170                 175     


Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile 
            180                 185                 190         


Ser Cys Arg Ser Ser Gln Asn Ile Ile His Ser Asp Gly Asp Thr Tyr 
        195                 200                 205             


Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser Pro Asn Leu Leu Ile 
    210                 215                 220                 


Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                245                 250                 255     


Asp Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala Ser His Val Pro Tyr 
            260                 265                 270         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Val Lys Arg Thr Thr Thr Pro 
        275                 280                 285             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    290                 295                 300                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
305                 310                 315                 320 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            340                 345                 350         


Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Val Asp 
        355                 360                 365             


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    370                 375                 380                 


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
385                 390                 395                 400 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520     


<210> 169

<400> 169
000


<210> 170
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 170
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 171
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 171
atggctcttc cggtaaccgc tctgctgctt cctttggctc tgcttcttca cgcggctagg       60

cca                                                                     63


<210> 172
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 172
Gly Ser 
1       


<210> 173
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 173
gggagc                                                                   6


<210> 174
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 174
Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


<210> 175
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 175
gaattgccta cgcaggggac tttttcaaat gtaagcacga atgtgagc                    48


<210> 176
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 176
Ser Pro 
1       


<210> 177
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 177
tctccg                                                                   6


<210> 178
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 178
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Phe Gly Gly Ser Ala Tyr Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Val Ser Glu Asp Thr Ala Ile Tyr Asn Cys Ala 
                85                  90                  95      


Arg His Gln Pro Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210> 179
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 179
gaagtcaaat tggtggagag tggcggtggg ctcgtaaaac caggaggcag cttgaaagta       60

agttgcacag cgtctgggtt cactttcagc cgatacgcta tgagttgggt gcggcaaacg      120

cccgaaagac gattggagtg ggtagctagt attacttttg ggggttccgc gtattacttg      180

gatagcgtta aagggagatt caccatatca cgagataatg cccaaaacat actctacctc      240

cagatgaact cattggtgtc tgaagatact gcaatttaca actgcgccag gcaccagcca      300

tggtttgact attggggtca aggtacgttg gtcacagtct cagcc                      345


<210> 180
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 180
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 181
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 181
ggcggtggcg gatctggagg gggaggcagt ggaggaggtg gttca                       45


<210> 182
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (30)..(30)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(112)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 182
Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Ile His Ser 
            20                  25                  30          


Asp Gly Asp Thr Tyr Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Val Lys 
            100                 105                 110         


<210> 183
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 183
gatgttctcc tgacgcaaac tcctttgtca ttgccggtaa gtctgggcga ccaagcgagc       60

atttcctgtc gcagcagcca gaacatarth catagtgatg gcgacactta cttggattgg      120

ttcctccaga aaccggggca atctccgaac ctcttgatat ataaggtctc aaatcgcttt      180

agcggggttc ccgaccgctt ttcaggttct ggctcaggta ccgatttcac gctgaaaatt      240

tctagagtag aggctgacga tctgggtgtt tactattgtt ttcaagcttc acacgttcct      300

tatacgttcg gaggggggac taaactggag gttaaa                                336


<210> 184
<211> 1
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 184
Arg 
1   


<210> 185
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 185
cgt                                                                      3


<210> 186
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 186
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 187
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 187
acgacgacac cagccccaag acccccaact cccgctccta ccatagcttc ccaacccctg       60

tcactgaggc cagaggcatg caggcccgct gcgggtggcg cggtacatac gcggggactg      120

gactttgcat gtgac                                                       135


<210> 188
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 188
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
            20                  25                  30          


Cys Lys Cys Pro Arg 
        35          


<210> 189
<211> 111
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 189
atttacatat gggcgccact ggcgggaaca tgtggagttt tgttgcttag cctggtcata       60

acactgtatt gcaatcatcg caacagacgc cgcgtctgca agtgtcccag g               111


<210> 190
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 190
Val Asp 
1       


<210> 191
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 191
gtcgac                                                                   6


<210> 192
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 192
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210> 193
<211> 123
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 193
agatctaaga gaagtagact tcttcacagt gattatatga atatgacgcc tcgaagaccc       60

ggcccgacac gcaaacacta tcagccgtat gccccccctc gggattttgc tgcctaccgc      120

agc                                                                    123


<210> 194
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 194
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 195
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 195
cgcgttaagt tctctaggtc cgctgacgcc cctgcctacc agcagggtca aaaccaactg       60

tacaatgaat tgaatcttgg gagacgggag gagtatgacg tactcgacaa gcggaggggg      120

agagatcctg agatgggtgg aaagcctcga cgaaaaaacc cacaagaagg gttgtataat      180

gaactgcaga aagacaagat ggctgaggca tatagtgaaa tcgggatgaa gggagaacgc      240

cggcgcggga aagggcacga tggtctgtat caagggctta gtacggctac gaaggacaca      300

tatgacgctt tgcacatgca ggcccttcct cctagg                                336


<210> 196
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 196
Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn 
1               5                   10                  15      


Val Ser Ser Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Arg Tyr Ala Met Ser Trp Val Arg His Thr Pro Glu Lys Arg 
    50                  55                  60                  


Leu Ala Trp Val Ala Ser Ile Thr Phe Gly Gly Asp Pro Tyr Tyr Pro 
65                  70                  75                  80  


Asp Gly Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Arg Asn 
                85                  90                  95      


Ile Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Val Arg His Glu Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser 
145                 150                 155                 160 


Leu Pro Val Ser Leu Gly Glu Gln Val Ser Ile Ser Cys Arg Ser Ser 
                165                 170                 175     


Gln Thr Ile Val His Thr Asp Gly Asn Ile Tyr Leu Glu Trp Tyr Leu 
            180                 185                 190         


Gln Asn Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn 
        195                 200                 205             


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile 
225                 230                 235                 240 


Tyr Tyr Cys Phe Gln Ala Ser His Val Pro Tyr Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
                325                 330                 335     


Arg Arg Arg Val Cys Lys Cys Pro Arg Val Asp Arg Ser Lys Arg Ser 
            340                 345                 350         


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        355                 360                 365             


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    370                 375                 380                 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210> 197
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (180)..(180)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(500)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 197
Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn 
1               5                   10                  15      


Val Ser Ser Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Thr Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Thr Phe Gly Gly Ser Ala Tyr Tyr Leu 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn 
                85                  90                  95      


Ile Leu Tyr Leu Gln Met Asn Ser Leu Val Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Asn Cys Ala Arg His Gln Pro Trp Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Val Leu Leu Thr Gln Thr Pro Leu Ser 
145                 150                 155                 160 


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
                165                 170                 175     


Gln Asn Ile Ile His Ser Asp Gly Asp Thr Tyr Leu Asp Trp Phe Leu 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn 
        195                 200                 205             


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Asp Asp Leu Gly Val 
225                 230                 235                 240 


Tyr Tyr Cys Phe Gln Ala Ser His Val Pro Tyr Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Val Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
                325                 330                 335     


Arg Arg Arg Val Cys Lys Cys Pro Arg Val Asp Arg Ser Lys Arg Ser 
            340                 345                 350         


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        355                 360                 365             


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    370                 375                 380                 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210> 198
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (180)..(180)
<223> /replace="Val"

<220>
<221> SITE
<222> (1)..(500)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 198
Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn 
1               5                   10                  15      


Val Ser Ser Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Lys Pro Gly Gly Ser Leu Lys Val Ser Cys Thr Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Thr Phe Gly Gly Ser Ala Tyr Tyr Leu 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn 
                85                  90                  95      


Ile Leu Tyr Leu Gln Met Asn Ser Leu Val Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Asn Cys Ala Arg His Gln Pro Trp Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Val Leu Leu Thr Gln Thr Pro Leu Ser 
145                 150                 155                 160 


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
                165                 170                 175     


Gln Asn Ile Ile His Ser Asp Gly Asp Thr Tyr Leu Asp Trp Phe Leu 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn 
        195                 200                 205             


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Asp Asp Leu Gly Val 
225                 230                 235                 240 


Tyr Tyr Cys Phe Gln Ala Ser His Val Pro Tyr Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Val Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
                325                 330                 335     


Arg Arg Arg Val Cys Lys Cys Pro Arg Val Asp Arg Ser Lys Arg Ser 
            340                 345                 350         


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        355                 360                 365             


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    370                 375                 380                 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210> 199
<211> 323
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 199
Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
145                 150                 155                 160 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                165                 170                 175     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg 
            180                 185                 190         


Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly 
        195                 200                 205             


Arg Gly Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    210                 215                 220                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
225                 230                 235                 240 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                245                 250                 255     


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            260                 265                 270         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        275                 280                 285             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    290                 295                 300                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
305                 310                 315                 320 


Pro Pro Arg 
            


<210> 200
<211> 348
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 200
Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn 
1               5                   10                  15      


Val Ser Ser Pro Gly Ser Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg 
            20                  25                  30          


Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
        35                  40                  45              


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
    50                  55                  60                  


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
65                  70                  75                  80  


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
                85                  90                  95      


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
            100                 105                 110         


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
        115                 120                 125             


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
    130                 135                 140                 


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
145                 150                 155                 160 


Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Cys Pro Ser Pro 
                165                 170                 175     


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
            180                 185                 190         


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
        195                 200                 205             


Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp 
    210                 215                 220                 


Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Arg Val Lys Phe Ser 
225                 230                 235                 240 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                245                 250                 255     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            260                 265                 270         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345             


<210> 201
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 201
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 202
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 202
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 203
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 203
His His His His His His 
1               5       


<210> 204
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 204
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 205
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 205
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210> 206
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 206
Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp 
1               5                   10      


<210> 207
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 207
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210> 208
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 208
Arg Arg Arg Arg Arg 
1               5   


<210> 209
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 209
Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210> 210
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 210
Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210> 211
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 211
Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


<210> 212
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 212
Lys Asp His Leu Ile His Asn Val His Lys Glu Phe His Ala His Ala 
1               5                   10                  15      


His Asn Lys 
            


<210> 213
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 213
Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210> 214
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> SITE
<222> (1)..(10) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (12)..(21) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (23)..(32) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (34)..(43) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (45)..(54) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (56)..(65) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (67)..(76) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (78)..(87) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (89)..(98) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (100)..(109) 
<223> /note="This region may encompass 2-10 residues"

<220>
<221> SITE
<222> (1)..(110) 
<223> /note="This sequence may encompass 2-10 '((G)xS)'
      repeating units where x is an integer between 2 and 10"

<400> 214
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
            100                 105                 110 


<210> 215
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 215
Gly Val Ile Leu Thr Ala Leu 
1               5           


<210> 216
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 216
gccaccatgc                                                              10


