
                                SEQUENCE LISTING

<110> BIONECURE THERAPEUTICS, INC.

<120> NOVEL MAYTANSINOIDS AS ADC PAYLOADS AND THEIR USE FOR
      THE TREATMENT OF CANCER

<130> 22736-20002.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> US 63/048,879
<151> 2020-07-07

<160> 9

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 1
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Gly Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Ser Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln
                85                  90                  95      
Ser Tyr Asn Leu Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 


<210> 2
<211> 389
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Ser Ala Leu Met Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn
 1               5                  10                  15      
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val
            20                  25                  30          
Tyr Tyr Cys Ala Arg Asp Glu Asn Trp Asp Gly Ala Trp Phe Ala Tyr
        35                  40                  45              
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
    50                  55                  60                  
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
65                  70                  75                  80  
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
                85                  90                  95      
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
            100                 105                 110         
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
        115                 120                 125             
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Ala Tyr Ile Cys Asn Val
    130                 135                 140                 
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Gly Pro Lys
145                 150                 155                 160 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
                165                 170                 175     
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            180                 185                 190         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        195                 200                 205             
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
    210                 215                 220                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
225                 230                 235                 240 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                245                 250                 255     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
            260                 265                 270         
Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        275                 280                 285             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Ala Lys Asn Gln
    290                 295                 300                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
305                 310                 315                 320 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                325                 330                 335     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            340                 345                 350         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        355                 360                 365             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    370                 375                 380                 
Leu Ser Pro Gly Lys
385                 


<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Thr Arg Lys Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Trp Ala Ser Ser Arg Glu Ser
 1               5          


<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Lys Gln Ser Tyr Asn Leu Phe Thr
 1               5              


<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Ser Tyr Gly Val Asn
 1               5  


<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Val Met Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser
 1               5                  10                  15      


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Asp Glu Asn Trp Asp Gly Ala Trp Phe Ala Tyr
 1               5                  10      


<210> 9
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Gly Pro Leu Gly
 1              

