                         SEQUENCE LISTING

<110>  TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
       RAMBAM MED-TECH LTD.
 
<120>  TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS mTOR AGONISTS MEDIATING
        PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN 
       THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE

<130>  2807807-JDB

<150>  US 62/705,668
<151>  2020-07-09

<150>  US 63/147,888
<151>  2021-02-10

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leucine-rich NES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any one of Leu, Ile, Val, Phe or Met

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid repeated n times, wherein n is 2 or 3

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any one of Leu, Ile, Val, Phe or Met

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid repeated n times, wherein n is 2 or 3

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any one of Leu, Ile, Val, Phe or Met

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is any one of Leu, Ile, Val, Phe or Met

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NES sequence

<400>  2

Leu Pro Pro Leu Glu Arg Leu Thr Leu 
1               5                   


<210>  3
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NES encoding sequence derived from p62

<400>  3
gcccgtcggc cgccgccaac tacctgctct gtaccaactg ccggaaagtg ctgcggaagg       60

ataaaagaat                                                              70


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NES sequence derived from p62

<400>  4

Ala Thr Gln Ser Leu Ala Glu Gln Met Arg Lys Ile Ala Leu Glu Ser 
1               5                   10                  15      


Glu Gly 
        


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Classical NLS, (monopartite)

<400>  5

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Classical NLS, (bipartite)


<220>
<221>  MISC_FEATURE
<222>  (3)..(12)
<223>  Xaa is any amino acid

<400>  6

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Lys Leu 
1               5                   10                  15      


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-classical NLS

<400>  7

Pro Arg Val Arg Tyr Asn Pro Tyr Thr Thr Arg Pro 
1               5                   10          


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NLS encoding sequence derived SV40

<400>  8
ccaccaaaga agaagagaaa ggtt                                              24


