                         SEQUENCE LISTING

<110>  WisTa Laboratories Ltd.
 
<120>  Tau antibodies for diagnostic and immunotherapeutic uses

<130>  P136455WO

<150>  GB2010652.2
<151>  2020-07-10

<160>  589   

<170>  PatentIn version 3.5

<210>  1
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  2
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser 
            500                 505                 510         


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
        515                 520                 525             


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
    530                 535                 540                 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
545                 550                 555                 560 


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
                565                 570                 575     


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            580                 585                 590         


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        595                 600                 605             


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    610                 615                 620                 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
625                 630                 635                 640 


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                645                 650                 655     


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            660                 665                 670         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        675                 680                 685             


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
    690                 695                 700                 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
705                 710                 715                 720 


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
                725                 730                 735     


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
            740                 745                 750         


Leu Ala Lys Gln Gly Leu 
        755             


<210>  3
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr 
1               5                   10                  15      


Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly 
            20                  25                  30          


Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu 
        35                  40                  45              


Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp 
    50                  55                  60                  


Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His 
65                  70                  75                  80  


Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
                85                  90                  95      


Glu 
    


<210>  4
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro 
1               5                   10                  15      


Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile 
            20                  25                  30          


His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
        35                  40                  45              


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
    50                  55                  60                  


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
65                  70                  75                  80  


Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu 
                85                  90                  95  


<210>  5
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro 
1               5                   10                  15      


Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile 
            20                  25                  30          


His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
        35                  40                  45              


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
    50                  55                  60                  


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
65                  70                  75                  80  


Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
                85                  90                  


<210>  6
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
        35                  40                  45              


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
    50                  55                  60                  


Lys Ile Glu Thr His Lys Leu Thr Phe 
65                  70              


<210>  7
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
1               5                   10                  15      


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
            20                  25                  30          


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
        35                  40                  45              


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
    50                  55                  60                  


Glu Thr His Lys Leu Thr Phe 
65                  70      


<210>  8
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 epitope

<400>  8

Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10              


<210>  9
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 general epitope


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  Where X is any amino acid

<400>  9

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Phe Xaa Xaa Arg 
1               5                   10                  


<210>  10
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  337-355 VHCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N or S

<400>  10

Xaa Asn Ala Val Gly 
1               5   


<210>  11
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  337-355 VHCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  T or K

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Y or H

<400>  11

Gly Cys Ser Ser Asp Gly Xaa Cys Tyr Xaa Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  337-355 VHCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  H or F or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or P

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  L or S

<400>  12

Gly Xaa Tyr Xaa Xaa Tyr Gly Tyr Asp Tyr Xaa Gly Thr Ile Asp Tyr 
1               5                   10                  15      


<210>  13
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  337-355 VLCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or nothing

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  G or R

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  S or D

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  G or A

<400>  13

Ser Gly Ser Ser Ser Asn Val Xaa Gly Xaa Asn Xaa Val Xaa 
1               5                   10                  


<210>  14
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  337-355 VLCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D or N or G

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N or T

<400>  14

Xaa Thr Xaa Ser Arg Pro Ser 
1               5           


<210>  15
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  337-355 VLCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  H or I

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  D or N

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  L or I

<400>  15

Xaa Xaa Gly Asp Ser Xaa Xaa Xaa Xaa Asp Xaa 
1               5                   10      


<210>  16
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 S1D12, S2C1

<400>  16

Asn Asn Ala Val Gly 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 ME12, NS3D9; VHCDR1 S1D2, S1H6, S2C3; VHCDR1 MC5, MD12; 
       VHCDR1 3aA6, VHCDR1 CE3

<400>  17

Ser Asn Ala Val Gly 
1               5   


<210>  18
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 S1D12, S2C1

<400>  18

Gly Cys Ser Ser Asp Gly Thr Cys Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 ME12

<400>  19

Gly Cys Ser Ser Asp Gly Lys Cys Tyr His Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 NS3D9, CE3

<400>  20

Gly Cys Ser Ser Asp Gly Lys Cys Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S1D12

<400>  21

Gly His Tyr Ser Ile Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp Tyr 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 ME12

<400>  22

Gly Phe Tyr Ser Ile Tyr Gly Tyr Asp Tyr Ser Gly Thr Ile Asp Tyr 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 NS3D9, CE3

<400>  23

Gly Tyr Tyr Pro Val Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp Tyr 
1               5                   10                  15      


<210>  24
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 S1D12, ME12

<400>  24

Ser Gly Ser Ser Ser Asn Val Gly Gly Gly Asn Ser Val Gly 
1               5                   10                  


<210>  25
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS3D9, CE3

<400>  25

Ser Gly Ser Ser Ser Asn Val Gly Arg Asn Asp Val Ala 
1               5                   10              


<210>  26
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 S1D12

<400>  26

Asp Thr Asn Ser Arg Pro Ser 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 ME12

<400>  27

Asn Thr Asn Ser Arg Pro Ser 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS3D9, CE3

<400>  28

Gly Thr Thr Ser Arg Pro Ser 
1               5           


<210>  29
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 S1D12

<400>  29

Val Thr Gly Asp Ser Thr Thr His Asp Asp Leu 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 ME12

<400>  30

Val Thr Gly Asp Ser Ser Thr His Asp Asp Leu 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS3D9, CE3

<400>  31

Ala Ser Gly Asp Ser Ser Ala Ile Asn Asp Ile 
1               5                   10      


<210>  32
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 amino acid sequence

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Val Gly Cys Ser Ser Asp Gly Thr Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly His Tyr Ser Ile Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser 
        115                 120                 125             


Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr 
    130                 135                 140                 


Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Ser Ser Ser Asn Val Gly Gly Gly Asn Ser Val Gly Trp 
                165                 170                 175     


Tyr Gln His Leu Pro Gly Ser Gly Leu Lys Thr Ile Ile Tyr Asp Thr 
            180                 185                 190         


Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Asn Ser Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Gly Asp Tyr Tyr Cys Val Thr Gly Asp Ser Thr Thr His Asp Asp Leu 
225                 230                 235                 240 


Val Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 250     


<210>  33
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2, CA9, CA12 general epitope


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  Where X is any amino acid

<400>  34

Xaa Xaa Xaa Lys Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  35
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  367 to 379 VHCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N or Y

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or A or Y

<400>  35

Xaa Xaa Xaa Val Gly 
1               5   


<210>  36
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  367 to 379 VHCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  G or S or N

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  D or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  E or Y or D or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  E or T or A

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  G or Y or F

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Y or F

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  N or K

<400>  36

Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Asn Pro Xaa Leu Xaa Ser 
1               5                   10                  15      


<210>  37
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  367 to 379 VHCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Y or V or A

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  R or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  A or T or G or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  D or nothing

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  G or nothing

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  L or Y or F or nothing

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  A or nothing

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or H

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  G or P

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Y or D

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Q or Y

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  A or Y

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Y or R or K

<400>  37

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Xaa Ile Xaa 
1               5                   10                  15      


Xaa 
    


<210>  38
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  367 to 379 VLCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or R

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  F or Y or D

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  I or L or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  G or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  I or S or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S or R or A or G

<400>  38

Ser Gly Xaa Xaa Xaa Xaa Xaa Ser Xaa Val Gly 
1               5                   10      


<210>  39
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC5, CA12, CA7, 412E10 and 412G11 VLCDR1

<400>  39

Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asn Tyr Val Gly 
1               5                   10                  


<210>  40
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  367 to 379 VLCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  S or A

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D or S or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  G or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  P or A

<400>  40

Xaa Xaa Xaa Xaa Arg Xaa Ser 
1               5           


<210>  41
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  367 to 379 VLCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  G or S

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  S or I or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or F or Y or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D or G or A or Q

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  R or P or nothing

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  T or nothing

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  P or Q or D or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Y or R or H or N

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  T or N

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  G or Y

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  V or I or L

<400>  41

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  42
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 S1G2, S1B1, S1D9, S1F4, S1G10, S1H9, S2C6, S2D1, S2D4, 
       CA9, CC12, S1A12, S1A5, S1E12, CB9

<400>  42

Ser Asn Ser Val Gly 
1               5   


<210>  43
<211>  729
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2B7 nucleotide sequence

<400>  43

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Gly Gly Gly Ala Cys Cys Cys Ala Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Ala Gly Cys Cys Cys Thr Cys Ala Cys Ala Gly 
        35                  40                  45              


Ala Cys Cys Cys Thr Cys Thr Cys Cys Cys Thr Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Gly Gly Thr Cys Thr Cys Thr Gly Gly Ala Thr Thr 
65                  70                  75                  80  


Cys Thr Cys Ala Thr Thr Ala Ala Cys Cys Ala Gly Cys Thr Gly Gly 
                85                  90                  95      


Gly Gly Thr Gly Thr Ala Gly Cys Thr Thr Gly Gly Gly Thr Cys Cys 
            100                 105                 110         


Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Ala Ala Ala 
        115                 120                 125             


Gly Gly Cys Ala Cys Thr Gly Gly Ala Gly Thr Gly Gly Cys Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Cys Cys Ala Thr Gly Cys Gly Thr Ala Gly Thr Gly 
145                 150                 155                 160 


Gly Thr Gly Gly Thr Gly Gly Thr Ala Cys Ala Gly Ala Ala Thr Ala 
                165                 170                 175     


Thr Ala Ala Thr Cys Cys Gly Gly Cys Cys Cys Thr Gly Ala Ala Ala 
            180                 185                 190         


Thr Cys Cys Cys Gly Cys Cys Thr Cys Ala Gly Cys Ala Thr Cys Ala 
        195                 200                 205             


Cys Cys Ala Gly Gly Gly Ala Cys Ala Cys Cys Thr Cys Cys Ala Ala 
    210                 215                 220                 


Gly Ala Gly Cys Cys Ala Ala Gly Thr Cys Thr Cys Cys Cys Thr Gly 
225                 230                 235                 240 


Thr Cys Ala Cys Thr Gly Ala Gly Cys Ala Gly Cys Gly Thr Gly Ala 
                245                 250                 255     


Cys Ala Ala Cys Thr Gly Ala Gly Gly Ala Cys Ala Thr Gly Gly Cys 
            260                 265                 270         


Cys Ala Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Thr Gly Cys Cys 
        275                 280                 285             


Ala Gly Ala Gly Gly Thr Thr Ala Thr Thr Thr Gly Ala Gly Thr Gly 
    290                 295                 300                 


Gly Thr Ala Thr Thr Cys Ala Thr Thr Ala Thr Gly Cys Cys Thr Gly 
305                 310                 315                 320 


Gly Gly Gly Cys Cys Gly Ala Gly Gly Ala Cys Thr Cys Cys Thr Ala 
                325                 330                 335     


Gly Thr Cys Thr Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly 
            340                 345                 350         


Ala Ala Gly Gly Thr Ala Ala Ala Thr Cys Thr Thr Cys Thr Gly Gly 
        355                 360                 365             


Cys Gly Cys Gly Thr Cys Thr Gly Gly Cys Gly Ala Gly Thr Cys Thr 
    370                 375                 380                 


Ala Ala Ala Gly Thr Gly Gly Ala Thr Gly Ala Cys Cys Ala Gly Gly 
385                 390                 395                 400 


Cys Thr Gly Thr Gly Cys Thr Gly Ala Cys Thr Cys Ala Gly Cys Thr 
                405                 410                 415     


Gly Thr Cys Cys Thr Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Gly 
            420                 425                 430         


Thr Cys Cys Cys Thr Gly Gly Gly Cys Cys Ala Gly Ala Gly Gly Gly 
        435                 440                 445             


Thr Cys Thr Cys Cys Ala Thr Cys Ala Cys Cys Thr Gly Cys Thr Cys 
    450                 455                 460                 


Thr Gly Gly Ala Ala Gly Cys Ala Gly Cys Ala Gly Cys Ala Ala Cys 
465                 470                 475                 480 


Gly Thr Thr Gly Gly Ala Gly Ala Thr Gly Gly Thr Gly Ala Thr Thr 
                485                 490                 495     


Ala Thr Gly Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Ala 
            500                 505                 510         


Ala Cys Ala Gly Cys Thr Cys Cys Cys Ala Gly Gly Ala Thr Cys Ala 
        515                 520                 525             


Gly Cys Cys Cys Cys Cys Ala Ala Ala Cys Thr Cys Cys Thr Cys Ala 
    530                 535                 540                 


Thr Cys Thr Ala Thr Ala Gly Thr Gly Cys Gly Cys Gly Cys Ala Ala 
545                 550                 555                 560 


Thr Cys Gly Ala Gly Cys Cys Thr Cys Gly Gly Gly Gly Gly Thr Cys 
                565                 570                 575     


Cys Cys Cys Gly Ala Cys Cys Gly Ala Thr Thr Cys Thr Cys Cys Gly 
            580                 585                 590         


Gly Cys Thr Cys Cys Ala Gly Gly Thr Cys Thr Gly Gly Cys Ala Ala 
        595                 600                 605             


Cys Ala Cys Ala Gly Cys Gly Ala Cys Thr Cys Thr Ala Ala Cys Cys 
    610                 615                 620                 


Ala Thr Cys Ala Cys Cys Thr Cys Gly Cys Thr Cys Cys Ala Gly Gly 
625                 630                 635                 640 


Cys Thr Gly Ala Gly Gly Ala Cys Gly Ala Gly Gly Cys Cys Gly Ala 
                645                 650                 655     


Thr Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Ala Thr Cys Thr 
            660                 665                 670         


Ala Thr Thr Gly Ala Cys Ala Cys Cys Ala Gly Thr Cys Gly Cys Thr 
        675                 680                 685             


Cys Thr Cys Ala Cys Ala Thr Thr Thr Thr Cys Gly Gly Cys Ala Gly 
    690                 695                 700                 


Cys Gly Gly Gly Ala Cys Cys Ala Gly Ala Cys Thr Gly Ala Cys Cys 
705                 710                 715                 720 


Gly Thr Cys Cys Thr Gly Gly Gly Thr 
                725                 


<210>  44
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 CA12, VHCDR1 CA7

<400>  44

Ser Tyr Tyr Val Gly 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 CB2, NS2A1

<400>  45

Thr Asn Ser Val Gly 
1               5   


<210>  46
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 S1G2, S1B1, S1F4, S1G10, S2D1, S2D4, CA9, S1A12, S1A5, 
       S1E12

<400>  46

Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn Ser 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 S1D2, S1H6, MD12

<400>  47

Ser Val Asp Ser Asp Gly Tyr Thr Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  48
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 S1D9, CC12, S1D5, CB9

<400>  48

Gly Ile Asp Ser Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn Ser 
1               5                   10                  15      


<210>  49
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 S1H9

<400>  49

Gly Ile Asp Ser Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  50
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 S2C3, MC5

<400>  50

Ser Val Asp Ser Asp Gly Asp Thr Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  51
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 S2C6

<400>  51

Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  52
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CA12, VHCDR2 CA7

<400>  52

Asn Ile Tyr Ser Thr Gly Arg Ala Phe Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  53
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CB2, NS2A1

<400>  53

Gly Ile Asp Thr Asp Gly Glu Glu Gly Phe Asn Pro Val Leu Lys Ser 
1               5                   10                  15      


<210>  54
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S1F4, S1G2, S1G10, CC12, S1E12, S1D5, CB9

<400>  54

Ser Tyr Arg Ala Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile Asp 
1               5                   10                  15      


Tyr 
    


<210>  55
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S1B1, S2D1, CB2, NS2A1

<400>  55

Ser Tyr Arg Thr Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile Asp 
1               5                   10                  15      


Tyr 
    


<210>  56
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S1D2, S1H6, MC5, MD12

<400>  56

Ser Val Asn Gly His Pro Asp Val Tyr Tyr Ile Asp Arg 
1               5                   10              


<210>  57
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S1D9

<400>  57

Thr Tyr Arg Thr Asp Gly Tyr Ala Tyr Gly Tyr Val Gln Ala Ile Asp 
1               5                   10                  15      


Tyr 
    


<210>  58
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S1H9, CA9

<400>  58

Ser Tyr Arg Ser Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile Asp 
1               5                   10                  15      


Tyr 
    


<210>  59
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S2C3

<400>  59

Ser Ala Asn Gly His Pro Asp Val Tyr Tyr Ile Asp Lys 
1               5                   10              


<210>  60
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S2C6

<400>  60

Thr Tyr Arg Thr Asp Gly Phe Ala Tyr Gly Tyr Val Gln Ala Ile Asp 
1               5                   10                  15      


Tyr 
    


<210>  61
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S2D4

<400>  61

Ser Tyr Arg Thr Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile Glu 
1               5                   10                  15      


Tyr 
    


<210>  62
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 antibody variable heavy chain

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Val Gly Cys Ser Ser Asp Gly Thr Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly His Tyr Ser Ile Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  63
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 S1G2, S1B1, S1D9, S1F4, S1G10, S1H9, CA9, S1A12, S1D5, 
       S1E12, S2C6

<400>  63

Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 S1D2, S2C3, MD12

<400>  64

Ser Gly Ser Tyr Ile Ser Ser Ser Arg Val Gly 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 S1H6

<400>  65

Ser Gly Ser Asp Leu Gly Ser Ser Arg Val Gly 
1               5                   10      


<210>  66
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 S2D1

<400>  66

Ser Gly Ser Tyr Ile Gly Ser Ser Ala Val Gly 
1               5                   10      


<210>  67
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 S2D4, CC12, CB9

<400>  67

Ser Gly Arg Phe Ile Gly Ile Ser Ser Val Gly 
1               5                   10      


<210>  68
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CB2, NS2A1

<400>  68

Ser Gly Ser Tyr Ile Gly Ser Ser Gly Val Gly 
1               5                   10      


<210>  69
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 MC5

<400>  69

Ser Gly Ser Tyr Val Ser Arg Ser Arg Val Gly 
1               5                   10      


<210>  70
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  297-390 VLCDR2 alternative consensus sequence, VLCDR2 S1G2, S1B1,
       S1D9, S1F4, S1G10, S1H9, S2D1, S2D4, CA9, CB2, CC12, NS2A1, 
       S1A12, S1D5, S1E12, CB9, S2C6

<400>  70

Ala Ser Asp Gly Arg Pro Ser 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 S1D2, S1H6, S2C3, MC5, MD12

<400>  71

Asp Ser Ser Ser Arg Pro Ser 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CA12 and CA7

<400>  72

Ala Ala Thr Ser Arg Ala Ser 
1               5           


<210>  73
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 S1G2

<400>  73

Gly Ser Ser Asp Arg Thr Pro Tyr Thr Gly Val 
1               5                   10      


<210>  74
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 S1B1, S1D9, S1F4, S1G10, S1H9, CA9, CC12, S1A12, S1D5, 
       S1E12, CB9, S2C6

<400>  74

Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Val 
1               5                   10      


<210>  75
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 S1D2, MD12

<400>  75

Gly Val Phe Gly Asp Arg Asn Tyr Ile 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 S1H6, S2C3

<400>  76

Gly Ile Phe Gly Asp Arg Asn Tyr Ile 
1               5                   


<210>  77
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 S2D4

<400>  77

Gly Ser Thr Ala Pro Thr Pro His Thr Gly Val 
1               5                   10      


<210>  78
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CA12 and CA7

<400>  78

Ser Ser Tyr Gln Arg Gly Asn Thr Gly Val 
1               5                   10  


<210>  79
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CB2 and NS2A1

<400>  79

Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Leu 
1               5                   10      


<210>  80
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 MC5

<400>  80

Gly Ile Tyr Gly Asp Arg Asn Tyr Ile 
1               5                   


<210>  81
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 amino acid sequence

<400>  81

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Ser Tyr Arg Ala Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Val 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Met Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Pro Tyr Thr Gly Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 


<210>  82
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  82

Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
1               5                   10                  15      


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
            20                  25                  30          


<210>  83
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  337 to 363 VHCDR1 consensus, VHCDR1 NS2A3, NS2A8, NS2C5, NS2C8, 
       NS2D3, CA4

<400>  83

Ser Tyr Ser Val Tyr 
1               5   


<210>  84
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  337 to 363 VHCDR2 consensus, VHCDR2 NS2A3, NS2A8, NS2C5, NS2C8, 
       NS2D3, CA4

<400>  84

Ile Met Tyr Ala Ser Gly Arg Val Asp Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  85
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  337 to 363 VHCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N or D

<400>  85

Gly Ile Glu Xaa 
1               


<210>  86
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  337 to 363 VLCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Q or E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N or G or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  S or A

<400>  86

Arg Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa 
1               5                   10      


<210>  87
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  337 to 363 VLCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Y or H

<400>  87

Tyr Ala Thr Tyr Leu Xaa Thr 
1               5           


<210>  88
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  337 to 363 VLCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D or G or E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  A or T

<400>  88

Leu Gln Tyr Xaa Xaa Thr Pro Leu Xaa 
1               5                   


<210>  89
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 NS2A3, NS2A8, NS2C8, CA4

<400>  89

Gly Ile Glu Asn 
1               


<210>  90
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 NS2C5, NS2D3

<400>  90

Gly Ile Glu Asp 
1               


<210>  91
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS2A3, NS2C8, CA4

<400>  91

Arg Thr Ser Gln Ser Val Asn Asn Tyr Leu Ser 
1               5                   10      


<210>  92
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS2A8

<400>  92

Arg Thr Asn Glu Ser Val Gly Asn Tyr Leu Ser 
1               5                   10      


<210>  93
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS2C5

<400>  93

Arg Thr Ser Gln Asn Ile Asp Asn Gly Leu Ala 
1               5                   10      


<210>  94
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS2D3

<400>  94

Arg Thr Ser Gln Ser Val Gly Ser Tyr Leu Ser 
1               5                   10      


<210>  95
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS2A3, NS2C8, CA4

<400>  95

Tyr Ala Thr Arg Leu Tyr Thr 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS2A8, NS2C5, NS2D3

<400>  96

Tyr Ala Thr Arg Leu His Thr 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS2A3, NS2C8, CA4

<400>  97

Leu Gln Tyr Asp Ser Thr Pro Leu Ala 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLDDR3 NS2D3

<400>  98

Leu Gln Tyr Asp Ser Thr Pro Leu Thr 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS2C5

<400>  99

Leu Gln Tyr Glu Ser Thr Pro Leu Ala 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS2A8

<400>  100

Leu Gln Tyr Gly Thr Thr Pro Leu Ala 
1               5                   


<210>  101
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  101

Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
1               5                   10                  15      


Lys Thr Asp His Gly Ala 
            20          


<210>  102
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  369 to 390 VHCDR1 consensus, NS4E3, NS3E5, NS3H4, NS4F2, NS2B6, 
       MD9

<400>  102

Arg Glu Ser Ile Ala 
1               5   


<210>  103
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  369 to 390 VHCDR2 consensus, NS4E3, NS3E5, NS3H4, NS4F2, NS2B6, 
       MD9

<400>  103

Gly Val Gly Ile Asp Gly Thr Ser Tyr Tyr Ser Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  104
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  369 to 390 VHCDR3 consensus, VHCDR3 NS4E3, NS3E5, NS3H4, NS4F2, 
       NS2B6, MD9

<400>  104

Asn Tyr Ile Asp Phe Glu Tyr 
1               5           


<210>  105
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  369 to 390 VLCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or N or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or N or nothing

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N or nothing

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  V or nothing

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or I

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or S or A or G

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  E or G or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  D or N or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Y or G or D

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  N or S or G

<400>  105

Ser Gly Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa 
1               5                   10                  


<210>  106
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  369 to 390 VLCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  G or R

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  T or N or S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N or T or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  P or A

<400>  106

Xaa Xaa Xaa Xaa Arg Xaa Ser 
1               5           


<210>  107
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  369 To 390 VLCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  L or A or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  R or T or G or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  G or N

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S or R or nothing

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  N or G or S or I

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  F or I or V

<400>  107

Xaa Ser Tyr Asp Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  108
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS4E3

<400>  108

Ser Gly Ser Ser Ser Asn Val Gly Tyr Glu Asp Tyr Val Asn 
1               5                   10                  


<210>  109
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS3H4

<400>  109

Ser Gly Ser Asn Ile Ala Gly Asn Gly Val Gly 
1               5                   10      


<210>  110
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS4F2

<400>  110

Ser Gly Ser Ser Asn Asn Val Gly Ser Gly Asp Tyr Val Ser 
1               5                   10                  


<210>  111
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS3E5

<400>  111

Ser Gly Ser Tyr Ile Gly Ser Thr Asp Val Gly 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS4E3

<400>  112

Gly Thr Thr Asn Arg Pro Ser 
1               5           


<210>  113
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS3E5

<400>  113

Gly Ser Thr Arg Arg Pro Ser 
1               5           


<210>  114
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS3H4

<400>  114

Arg Asn Ser Asn Arg Pro Ser 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS4F2

<400>  115

Arg Thr Thr Thr Arg Ala Ser 
1               5           


<210>  116
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS4E3

<400>  116

Leu Ser Tyr Asp Arg Ser Gly Ser Asn Phe 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS4F2

<400>  117

Ala Ser Tyr Asp Thr Ser Asn Arg Gly Ile 
1               5                   10  


<210>  118
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS3H4

<400>  118

Gly Ser Tyr Asp Gly Thr Asn Ser Phe 
1               5                   


<210>  119
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS3E5

<400>  119

Ala Ser Tyr Asp Ser Asn Asn Ser Ile Val 
1               5                   10  


<210>  120
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  120

Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
1               5                   10                  15      


Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            20                  25                  30  


<210>  121
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  412 to 441 VHCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D or Y

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or G or A

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  V or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  A or G

<400>  121

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  122
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  412 to 441 VHCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A or N

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  S or I

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  G or Y or W

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N or S or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  K or T or I

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or E

<400>  122

Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  123
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  412 to 441 VHCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  I or G

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  A or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  G or S

<400>  123

Gly Xaa Xaa Xaa Xaa Val Asp Val 
1               5               


<210>  124
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHDR3 412G11

<400>  124

Ser Gly Gly Asp 
1               


<210>  125
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  412 to 441 VLCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Y or R

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  N or D or T

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Y or F

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  G or D

<400>  125

Ser Gly Xaa Xaa Asn Xaa Gly Xaa Gly Xaa Xaa Val Xaa 
1               5                   10              


<210>  126
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  412 To 441 VLCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  A or D or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  I or S or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  A or P

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  S or P

<400>  126

Gly Xaa Xaa Xaa Arg Xaa Xaa 
1               5           


<210>  127
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  412 to 441 VLCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Q or D

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or Y or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Y or D or N or E

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  A or G or D or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Nothing or G or M or V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Nothing or I

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  F or V or I

<400>  127

Ala Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  128
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 412E10 and 412B9

<400>  128

Ser Asp Ser Val Ala 
1               5   


<210>  129
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 412E6

<400>  129

Asn Tyr Gly Val Gly 
1               5   


<210>  130
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 412G11

<400>  130

Ser Tyr Ala Leu Gly 
1               5   


<210>  131
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 412E10 and 412B9

<400>  131

Ala Ser Gly Ser Ser Gly Asn Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  132
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 412G11

<400>  132

Asn Ile Trp Arg Gly Gly Arg Ile Glu Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  133
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 412E6

<400>  133

Asn Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  134
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 412E10 and 412B9

<400>  134

Gly Ile Ile Ala Gly Val Asp Val 
1               5               


<210>  135
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 412E6

<400>  135

Gly Gly Val Gly Ser Val Asp Val 
1               5               


<210>  136
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  297 to 390 VHCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S or R or D or T

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N or E or Y or H

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  G or A

<400>  136

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  137
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 412E6

<400>  137

Ser Gly Gly Arg Asn Asn Ile Gly Arg Gly Thr Phe Val Asp 
1               5                   10                  


<210>  138
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 412B9, 3aD3, 3aA6

<400>  138

Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asp Tyr Val Gly 
1               5                   10                  


<210>  139
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 412E10

<400>  139

Gly Thr Ala Ile Arg Ala Ser 
1               5           


<210>  140
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 412B9

<400>  140

Ala Ala Ser Arg Ala Ser 
1               5       


<210>  141
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 412G11, VLCDR2 3aG3, VLCDR2 3bF4, VLCDR2 CB7, CG11, 
       CE2/E1B8, CC5

<400>  141

Gly Ala Thr Ser Arg Ala Ser 
1               5           


<210>  142
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 412E6

<400>  142

Gly Thr Asp Arg Arg Pro Pro 
1               5           


<210>  143
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 412E10

<400>  143

Ala Ser Tyr Gln Ser Asn Tyr Ala Phe 
1               5                   


<210>  144
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 412G11

<400>  144

Ala Ser Tyr Asp Arg Ser Glu Ser Val Val 
1               5                   10  


<210>  145
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 412B9

<400>  145

Ala Ser Tyr Asp Ser Ser Asp Gly Gly Val 
1               5                   10  


<210>  146
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 412E6

<400>  146

Ala Thr Tyr Asp Tyr Ser Asn Asp Met Ile Ile 
1               5                   10      


<210>  147
<211>  241
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 amino acid sequence

<400>  147

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Val Ile Ser Asp 
            20                  25                  30          


Ser Val Ala Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Ala Ser Gly Ser Ser Gly Asn Lys Tyr Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ile Ile Ala Gly Val Asp Val Trp Gly Arg Gly Leu Leu Val 
            100                 105                 110         


Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser Lys 
        115                 120                 125             


Val Asp Asp Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser 
    130                 135                 140                 


Leu Gly Gln Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val 
145                 150                 155                 160 


Gly Tyr Gly Asn Tyr Val Gly Trp Tyr Gln Gln Val Pro Gly Ser Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Gly Thr Ala Ile Arg Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Arg Ser Gly Asp Thr Ala Thr Leu Thr Ile 
        195                 200                 205             


Thr Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr 
    210                 215                 220                 


Gln Ser Asn Tyr Ala Phe Phe Gly Ser Gly Thr Arg Leu Thr Val Leu 
225                 230                 235                 240 


Gly 
    


<210>  148
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln 
    


<210>  149
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  1 to 49 VHCDR1 consensus, VHCDR1 3aG3, VHCDR1 3aD3, VHCDR1 3aH6, 
       VHCDR1 3bG4; 49 to 111 VHCDR1 consensus, VHCDR1 3aB7, VHCDR1 3bF4

<400>  149

Ser Asn Gly Val Gly 
1               5   


<210>  150
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  1 to 49 VHDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or A

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or V or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  A or K or V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  A or S or G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  N or H

<400>  150

Asp Ile Xaa Ser Xaa Gly Lys Xaa Tyr Xaa Xaa Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  151
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  1 to 49 VHDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  I or S

<400>  151

Cys Arg Asp Gly Gly Val Xaa Tyr Gly Tyr Asp Xaa Asp Tyr 
1               5                   10                  


<210>  152
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  1 to 49 VLDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  G or S or Y

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  N or D

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Y or D

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  L or V

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  S or G

<400>  152

Ser Gly Ser Xaa Xaa Asn Xaa Gly Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10                  


<210>  153
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  1 to 49 VLDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or N or E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  R or L

<400>  153

Gly Xaa Thr Xaa Xaa Ala Ser 
1               5           


<210>  154
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  1 to 49 VLDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A or G

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  F or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  T or S or D

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  I or V

<400>  154

Xaa Ser Xaa Asp Xaa Xaa Ser Gly Gly Xaa 
1               5                   10  


<210>  155
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 3aG3

<400>  155

Asp Ile Ser Ser Ser Gly Lys Ala Tyr Ala Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  156
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 3aD3

<400>  156

Asp Ile Ser Ser Gly Gly Lys Val Tyr Gly His Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  157
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 3aH6, VHCDR2 3bF4, VHCDR2 CA2, VHCDR2 CB6, VHCDR2 CA10

<400>  157

Asp Ile Ser Ser Val Gly Lys Lys Tyr Ala Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  158
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 3bG4, CC4

<400>  158

Asp Ile Ala Ser Ser Gly Lys Ala Tyr Ser Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  159
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 3aG3

<400>  159

Cys Arg Asp Gly Gly Val Ser Tyr Gly Tyr Asp Ile Asp Tyr 
1               5                   10                  


<210>  160
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 3aD3, CB5

<400>  160

Cys Arg Asp Gly Gly Val Ser Tyr Gly Tyr Asp Ser Asp Tyr 
1               5                   10                  


<210>  161
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 3aH6, VHCDR3 3bG4 VHCDR3 3bF4, VHCDR3 CA2, VHCDR3 CB6, 
       VHCDR3 CA10, VHCDR3 CA6, VHCDR3 CC4, VHCDR3 CC5, VHCDR3 CA2

<400>  161

Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Ile Asp Tyr 
1               5                   10                  


<210>  162
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  297 to 390 VHCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D or G or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  T or I or Y or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  E or T or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  E or S or T

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  G or Y or E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Y or F

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  P or S

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  N or K

<400>  162

Gly Xaa Xaa Xaa Asp Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Ser 
1               5                   10                  15      


<210>  163
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 3aG3

<400>  163

Ser Gly Ser Ser Ser Asn Ile Gly Gly Gly Asn Tyr Leu Ser 
1               5                   10                  


<210>  164
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  297 to 390 VHCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S or N or D or T

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Y or nothing or S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  R or nothing or K

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  A or nothing or G or S or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  D or nothing

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  G or nothing

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  L or nothing or Y

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  A or nothing or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or nothing or W

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  G or nothing

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Y or nothing or H

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  V or Y

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Q or I or Y

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  A or D or Q

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  I or F

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  D or E

<400>  164

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Tyr 
    


<210>  165
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 3aH6, VLCDR1 CA2

<400>  165

Ser Gly Ser Ser Gly Asn Val Gly Tyr Gly Asp Tyr Val Ser 
1               5                   10                  


<210>  166
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 3bG4

<400>  166

Ser Gly Ser Thr Ser Asn Val Gly Ser Gly Asn Asp Val Ser 
1               5                   10                  


<210>  167
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  297 to 390 VLCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  F or N or S or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  I or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  G or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  I or S or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S or A or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S or Y or G

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Nothing or G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Nothing or D

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Nothing or Y

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  G or T or S

<400>  167

Ser Gly Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa 
1               5                   10                  


<210>  168
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 3aD3

<400>  168

Gly Val Thr Glu Arg Ala Ser 
1               5           


<210>  169
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 3aH6, VLCDR2 CA2

<400>  169

Gly Ala Thr Asn Leu Ala Ser 
1               5           


<210>  170
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 E2A6, 3bG4, CC4

<400>  170

Gly Ala Thr Asn Arg Ala Ser 
1               5           


<210>  171
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 3aG3

<400>  171

Ala Ser Phe Asp Thr Ser Ser Gly Gly Ile 
1               5                   10  


<210>  172
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 3aD3

<400>  172

Ala Ser Tyr Asp Asp Ser Ser Gly Gly Ile 
1               5                   10  


<210>  173
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 3aH6, VLCDR3 CA2

<400>  173

Ala Ser Tyr Asp Ser Ser Ser Gly Gly Val 
1               5                   10  


<210>  174
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 3bG4

<400>  174

Gly Ser Tyr Asp Ser Asn Ser Gly Gly Ile 
1               5                   10  


<210>  175
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  175

Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
1               5                   10                  15      


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
            20                  25                  30          


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
        35                  40                  45              


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr 
    50                  55                  60              


<210>  176
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  49 to 111 VHCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  I or K

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  K orT

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  A or G

<400>  176

Asp Xaa Ser Ser Xaa Ser Lys Xaa Tyr Xaa Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  177
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  49 to 111 VHCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  I or V

<400>  177

Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Xaa Asp Tyr 
1               5                   10                  


<210>  178
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  49 to 111 VLCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  L or Y

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  R or G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  N or D

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Y or V

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  T or S

<400>  178

Ser Gly Ser Ser Ser Asn Val Gly Xaa Xaa Xaa Xaa Val Xaa 
1               5                   10                  


<210>  179
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  49 to 111 VLCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<400>  179

Gly Xaa Thr Xaa Arg Ala Ser 
1               5           


<210>  180
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  49 to 111 VLCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  A or F

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N or D

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  V or I

<400>  180

Ala Ser Xaa Asp Xaa Xaa Xaa Gly Gly Xaa 
1               5                   10  


<210>  181
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  297 to 390 VLCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A or R or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  S or N or A

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D or R or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  G or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  P or A

<400>  181

Xaa Xaa Xaa Xaa Arg Xaa Ser 
1               5           


<210>  182
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 3aB7, CB12, CC3, CA3, CD1

<400>  182

Asp Lys Ser Ser Ala Gly Lys Thr Tyr Gly Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  183
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  297 to 390 VLCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  G or A

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  S or Y or H

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D or nothing

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  R or Q or D

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  T or S or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Q or W or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Y or G or I

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  G or A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  V or L

<400>  183

Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  184
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 3aB7, CA3

<400>  184

Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Val Asp Tyr 
1               5                   10                  


<210>  185
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 3bF4

<400>  185

Ser Gly Ser Ser Ser Asn Val Gly Leu Arg Asn Tyr Val Thr 
1               5                   10                  


<210>  186
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 3aB7

<400>  186

Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asp Val Val Ser 
1               5                   10                  


<210>  187
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 S1D5

<400>  187

Ser His Ser Val Gly 
1               5   


<210>  188
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 3aB7, CC3, CD1

<400>  188

Gly Thr Thr Thr Arg Ala Ser 
1               5           


<210>  189
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 3bF4

<400>  189

Ala Ser Ala Asp Thr Asn Asp Gly Gly Val 
1               5                   10  


<210>  190
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 3aB7

<400>  190

Ala Ser Phe Asp Ser Asp Ser Gly Gly Ile 
1               5                   10  


<210>  191
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  191

Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
1               5                   10      


<210>  192
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  147 to 157 VHCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  I or G

<400>  192

Ser Asn Ala Val Xaa 
1               5   


<210>  193
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  147 to 157 VHCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  A or T

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  D or N

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  K or E

<400>  193

Leu Ile Asp Xaa Asp Gly Asp Xaa Ala Tyr Xaa Pro Ala Leu Xaa Ser 
1               5                   10                  15      


<210>  194
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  147 to 157 VHCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D or H

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  G or D

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or K

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S or D

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  D or S

<400>  194

Xaa Tyr Xaa Xaa Trp Gly Tyr Xaa Xaa Xaa Ile Asp Tyr 
1               5                   10              


<210>  195
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  147 to 157 VLCDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Nothing or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Nothing or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Nothing or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  I or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  G or Y

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  A or D

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D or Y

<400>  195

Ser Gly Ser Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Val Gly 
1               5                   10                  


<210>  196
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  147 to 157 VLCDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N or A

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  P or A

<400>  196

Asp Xaa Xaa Xaa Arg Xaa Ser 
1               5           


<210>  197
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  147 to 157 VLCDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  G or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or Q

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  G or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  A or E

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Y or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  I or V

<400>  197

Xaa Xaa Tyr Xaa Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   10  


<210>  198
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 3aD6, CB11, CC7, CA1, CD2

<400>  198

Ser Asn Ala Val Ile 
1               5   


<210>  199
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 NS1B2

<400>  199

Asp Tyr Gly Ile Gly 
1               5   


<210>  200
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 3aD6, CB11, CC7, CD2

<400>  200

Leu Ile Asp Val Asp Gly Asp Ala Ala Tyr Asp Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  201
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 3aA6

<400>  201

Leu Ile Asp Ile Asp Gly Asp Thr Ala Tyr Asn Pro Ala Leu Glu Ser 
1               5                   10                  15      


<210>  202
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 3aD6, CB11, CC7, CD2

<400>  202

Asp Tyr Gly Ser Trp Gly Tyr Val Ser Asp Ile Asp Tyr 
1               5                   10              


<210>  203
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 3aA6

<400>  203

His Tyr Asp Lys Trp Gly Tyr Ala Asp Ser Ile Asp Tyr 
1               5                   10              


<210>  204
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 3aD6

<400>  204

Ser Gly Ser Asp Ile Gly Gly Ala Asp Val Gly 
1               5                   10      


<210>  205
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHDR2 NS1B2

<400>  205

Gly Ile Asn Tyr Asp Gly Arg Thr Glu Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  206
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 3aD6

<400>  206

Asp Asn Asp Asn Arg Pro Ser 
1               5           


<210>  207
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 3aA6, CA6

<400>  207

Asp Ala Thr Thr Arg Ala Ser 
1               5           


<210>  208
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 3aD6

<400>  208

Gly Thr Tyr Ser Gly Ala Asn Tyr Gly Ile 
1               5                   10  


<210>  209
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 3aA6

<400>  209

Ala Ser Tyr Gln Asn Glu Arg Ser Gly Val 
1               5                   10  


<210>  210
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S1A12, S1A5

<400>  210

Thr Tyr Arg Ser Asp Gly Tyr Ala Tyr Gly Tyr Val Gln Ala Ile Asp 
1               5                   10                  15      


Tyr 
    


<210>  211
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 NS1B2

<400>  211

Asp Ser Lys Gly Gly Trp Gly His Val Tyr Gln Phe Asp Tyr 
1               5                   10                  


<210>  212
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS2B6

<400>  212

Ser Gly Ser Asn Ile Gly Ser Ala Ser Val Thr 
1               5                   10      


<210>  213
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS1B2

<400>  213

Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asp Tyr Val Ser 
1               5                   10                  


<210>  214
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS2B6

<400>  214

Arg Asn Arg Asn Arg Pro Ser 
1               5           


<210>  215
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS1B2

<400>  215

Asp Ala Thr Asn Arg Ala Ser 
1               5           


<210>  216
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS1B2

<400>  216

Ala Ser His Asp Asn Arg Ile Ser Ala Val 
1               5                   10  


<210>  217
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS2B6

<400>  217

Gly Ser Tyr Gln Ser Trp Gly Ser Gly Val 
1               5                   10  


<210>  218
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1E12 amino acid sequence

<400>  218

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Gly Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Ser Tyr Arg Ala Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Arg Val Val Arg 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Met Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 


<210>  219
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1E12 nucleotide sequence

<400>  219
caggtgcagt tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctccggatt ctcattaggc agcaattctg taggctgggt ccgccaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctataat      180

ccagccctta actcccggct cagcatcacc agggacacct ccaagagtca ggtctctttg      240

tcattgagca gcgtgacaag tgaggacacg gccgtgtact actgtggaag aagttatagg      300

gctgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcaccgtct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

agggtcgtgc ggactcaacc gtcctccgtg tctgggtccc tgggccagag ggtctccatc      480

acctgctctg gaagcttcat cggtattagt agtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccatcat cgtggcgagt gacggtcgac cctcaggggt ccccgaccga      600

ttctctatgt ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc aatatactgg agttttcggc      720

agcgggacca ggctgaccgt cctgggt                                          747


<210>  220
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  NS2A1 amino acid sequence

<400>  220

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Phe Asn Pro Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Asn Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Ser Tyr Arg Thr Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Ile Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Gly Ser Pro Gly Gln Thr Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Tyr Ile Gly Ser Ser Gly Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Gly Phe Ser Met Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Leu Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 


<210>  221
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8, E1E8 epitope, residues 379-391

<400>  221

Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu 
1               5                   10              


<210>  222
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8, E1E8 general epitope


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Where X is any amino acid

<400>  222

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu 
1               5                   10              


<210>  223
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  379-391 VHDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D or S

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  R or W

<400>  223

Xaa Xaa Gly Val Ala 
1               5   


<210>  224
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  379-391 VHDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  T or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  I or T

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Y or D

<400>  224

Thr Met Arg Ser Gly Gly Xaa Xaa Xaa Xaa Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  225
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  379-391 VHDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D or I or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  R or H

<400>  225

Gly Tyr Leu Ser Gly Xaa Xaa Tyr Ala 
1               5                   


<210>  226
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  379-391 VLDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  R or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y or D or A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  N or D or R

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  S or G

<400>  226

Ser Gly Ser Xaa Ser Xaa Xaa Gly Xaa Gly Xaa Tyr Val Xaa 
1               5                   10                  


<210>  227
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  379-391 VLDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D or S or G

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N or R or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  T or N or S

<400>  227

Xaa Xaa Xaa Xaa Arg Ala Ser 
1               5           


<210>  228
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  379-391 VLDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S or G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  R or N

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  H or L

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  L or I

<400>  228

Ala Xaa Ile Asp Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  229
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 E2E8

<400>  229

Asp Arg Gly Val Ala 
1               5   


<210>  230
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 E1E8, E2A6

<400>  230

Asp Trp Gly Val Ala 
1               5   


<210>  231
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 E2B7

<400>  231

Ser Trp Gly Val Ala 
1               5   


<210>  232
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 E2E8

<400>  232

Thr Met Arg Ser Gly Gly Thr Ile Asp Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  233
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 E2B7

<400>  233

Thr Met Arg Ser Gly Gly Gly Thr Glu Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  234
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 E1E8, E2A6

<400>  234

Thr Met Arg Ser Gly Gly Thr Thr Asp Asp Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  235
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 E2E8

<400>  235

Gly Tyr Leu Ser Gly Asp Arg Tyr Ala 
1               5                   


<210>  236
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 E2B7

<400>  236

Gly Tyr Leu Ser Gly Ile His Tyr Ala 
1               5                   


<210>  237
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 E1E8, E2A6

<400>  237

Gly Tyr Leu Ser Gly Val His Tyr Ala 
1               5                   


<210>  238
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 E2E8

<400>  238

Ser Gly Ser Arg Ser Asp Ile Gly Tyr Gly Asn Tyr Val Ser 
1               5                   10                  


<210>  239
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 E2A6

<400>  239

Ser Gly Ser Ser Ser Asn Val Gly Ala Gly Asn Tyr Val Gly 
1               5                   10                  


<210>  240
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 E2B7

<400>  240

Ser Gly Ser Ser Ser Asn Val Gly Asp Gly Asp Tyr Val Gly 
1               5                   10                  


<210>  241
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 E1E8

<400>  241

Ser Gly Ser Ser Ser Asn Val Gly Asp Gly Arg Tyr Val Ser 
1               5                   10                  


<210>  242
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 E2E8

<400>  242

Asp Thr Asn Thr Arg Ala Ser 
1               5           


<210>  243
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 E1E8

<400>  243

Asp Thr Thr Ser Arg Ala Ser 
1               5           


<210>  244
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 E2B7

<400>  244

Ser Ala Arg Asn Arg Ala Ser 
1               5           


<210>  245
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 E2E8

<400>  245

Ala Asn Ile Asp Ser Ser Arg Ser His Leu 
1               5                   10  


<210>  246
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 E1E8

<400>  246

Ala Ser Ile Asp Ser Gly Asn Asn Leu Leu 
1               5                   10  


<210>  247
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 E2A6, E2B7

<400>  247

Ala Ser Ile Asp Thr Ser Arg Ser His Ile 
1               5                   10  


<210>  248
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 amino acid sequence

<400>  248

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Arg 
            20                  25                  30          


Gly Val Ala Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Gly Thr Met Arg Ser Gly Gly Thr Ile Asp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Met Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Leu Ser Gly Asp Arg Tyr Ala Trp Gly Arg Gly Leu Leu 
            100                 105                 110         


Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser 
        115                 120                 125             


Lys Val Asp Asp Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys 
    130                 135                 140                 


Ser Leu Gly Gln Ser Val Ser Ile Ala Cys Ser Gly Ser Arg Ser Asp 
145                 150                 155                 160 


Ile Gly Tyr Gly Asn Tyr Val Ser Trp Phe Gln Gln Ile Pro Gly Ser 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Thr Asn Thr Arg Ala Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ala Arg Ser Gly Asn Thr Ala Thr Leu Thr 
        195                 200                 205             


Ile Asn Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Asn 
    210                 215                 220                 


Ile Asp Ser Ser Arg Ser His Leu Phe Gly Ser Gly Thr Arg Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  249
<211>  729
<212>  DNA
<213>  artificial sequence

<220>
<223>  E2E8 nucleotide sequence

<400>  249
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc gaccgtggtg tagcctgggt ccgccaggct      120

ccaggaaagg cactggagtg ggttggtact atgcgtagtg gtggaacgat agactataac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagcca agttttcctg      240

tcactgagca gcgtcacaac tgaggacatg gccatgtact actgtgccag aggttatttg      300

agcggtgatc gttatgcctg gggccgagga ctcctggtca ccgtctcctc agaaggtaaa      360

tcttctggcg cgtctggcga gtctaaagtg gatgaccagg ctgtgctgac tcagccgtcc      420

tccgtgtcca agtccctggg ccagagtgtc tccatcgcct gctctggaag caggagcgac      480

attggatatg gtaattatgt gagctggttc caacagatcc caggatcagc ccccaaactc      540

cttatttatg atacaaacac tcgggcctcg ggggtccccg accgattctc cggcgccagg      600

tctggcaaca cagcaacact gaccatcaac tcgctccagg ctgaggacga ggccgattat      660

tactgtgcaa atattgacag tagtcgcagt catcttttcg gcagtggcac cagactgacc      720

gtcctgggt                                                              729


<210>  250
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  E1E8 amino acid sequence

<400>  250

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Trp 
            20                  25                  30          


Gly Val Ala Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Thr Met Arg Ser Gly Gly Thr Thr Asp Asp Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Met Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Leu Ser Gly Val His Tyr Ala Trp Gly Arg Gly Leu Leu 
            100                 105                 110         


Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser 
        115                 120                 125             


Lys Val Asp Asp Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly 
    130                 135                 140                 


Ser Leu Gly Gln Ser Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Val Gly Asp Gly Arg Tyr Val Ser Trp Phe Gln Gln Val Pro Gly Ser 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Thr Thr Ser Arg Ala Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Ile 
        195                 200                 205             


Ile Thr Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
    210                 215                 220                 


Ile Asp Ser Gly Asn Asn Leu Leu Phe Gly Ser Gly Thr Arg Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  251
<211>  729
<212>  DNA
<213>  artificial sequence

<220>
<223>  E1E8 nucleotide sequence

<400>  251
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaact gactggggtg tagcttgggt ccgccaggct      120

ccaggaaagg cactggagtg gcttggtacg atgcgtagtg gtgggactac agacgataac      180

ccggccctga aatcccgcct cagcatcacc agggacacct ctaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggacatg gccatgtact actgtgccag aggttatttg      300

agtggtgtgc attatgcctg gggccgagga ctcctggtca ccgtctcctc agaaggtaaa      360

tcttctggcg cgtctggcga gtctaaagtg gatgaccagg ctgtgctgac tcagccgtcc      420

tccgtatctg ggtccctggg ccagagtgtc tccatcacct gctctggaag cagcagcaac      480

gtgggagatg gtagatatgt gagctggttc caacaggtcc caggatcagc ccccaaactc      540

ctcatctatg atacaaccag tcgagcctcg ggggttcccg accgattctc cggctccagg      600

tctggcaaca cagcgactct catcatcacc tcgctccagg ctgaggacga ggccgattat      660

tactgtgcat ctattgacag cggtaacaat cttcttttcg gcagcggcac caggctgacc      720

gtcctgggt                                                              729


<210>  252
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2A6 amino acid sequence

<400>  252

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Trp 
            20                  25                  30          


Gly Val Ala Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Thr Met Arg Ser Gly Gly Thr Thr Asp Asp Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Met Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Leu Ser Gly Val His Tyr Ala Trp Gly Arg Gly Leu Leu 
            100                 105                 110         


Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser 
        115                 120                 125             


Lys Val Asp Asp Arg Val Val Arg Thr Gln Pro Ser Ser Val Ser Lys 
    130                 135                 140                 


Ser Leu Gly Gln Ser Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Val Gly Ala Gly Asn Tyr Val Gly Trp Phe Gln Gln Val Pro Gly Ser 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Gly Ala Thr Asn Arg Ala Ser Gly Val 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Lys Ser Gly Val Thr Ala Thr Leu Thr 
        195                 200                 205             


Ile Thr Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
    210                 215                 220                 


Ile Asp Thr Ser Arg Ser His Ile Phe Gly Ser Gly Thr Arg Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  253
<211>  729
<212>  DNA
<213>  artificial sequence

<220>
<223>  E2A6 nucleotide sequence

<400>  253
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaact gactggggtg tagcttgggt ccgccaggct      120

ccaggaaagg cactggagtg gcttggtacg atgcgtagtg gtgggactac agacgataac      180

ccggccctga aatcccgcct cagcatcacc agggacacct ctaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggacatg gccatgtact actgtgccag aggttatttg      300

agtggtgtgc attatgcctg gggccgagga ctcctggtca ccgtctcctc agaaggtaaa      360

tcttctggcg cgtctggcga gtctaaagtg gatgaccggg tcgtgcggac tcagccgtcc      420

tccgtgtcca agtccctggg ccagagtgtc tccatcacct gctctggaag cagcagcaac      480

gttggagctg gtaattatgt gggctggttc caacaggtcc caggatcagc ccccaaactc      540

ctcatctatg gtgcaaccaa tcgagcctcg ggggtccccg cccgattctc aggctccaag      600

tctggcgtca cagcgactct aaccatcacc tcgctccagg ctgaggacga ggccgattat      660

tactgtgcat ctattgacac cagtcgctct cacattttcg gcagcgggac caggctgacc      720

gtcctgggt                                                              729


<210>  254
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2B7 amino acid sequence

<400>  254

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Trp 
            20                  25                  30          


Gly Val Ala Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Thr Met Arg Ser Gly Gly Gly Thr Glu Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Met Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Leu Ser Gly Ile His Tyr Ala Trp Gly Arg Gly Leu Leu 
            100                 105                 110         


Val Ser Val Ser Ser Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser 
        115                 120                 125             


Lys Val Asp Asp Gln Ala Val Leu Thr Gln Leu Ser Ser Val Ser Gly 
    130                 135                 140                 


Ser Leu Gly Gln Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Val Gly Asp Gly Asp Tyr Val Gly Trp Phe Gln Gln Leu Pro Gly Ser 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Arg Asn Arg Ala Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr 
        195                 200                 205             


Ile Thr Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser 
    210                 215                 220                 


Ile Asp Thr Ser Arg Ser His Ile Phe Gly Ser Gly Thr Arg Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  255
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  255

Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
1               5                   10                  15      


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
            20                  25                  30          


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
        35                  40                  45              


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
    50                  55                  60                  


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
65                  70                  75                  80  


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
                85                  90                  95      


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
            100                 105                 110         


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser 
        115                 120                 125     


<210>  256
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CB11

<400>  256

Ser Gly Ser Asn Ile Gly Ser Asn Asp Val Gly 
1               5                   10      


<210>  257
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CB11

<400>  257

Asp Asn Asn Asn Arg Pro Ser 
1               5           


<210>  258
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CB11

<400>  258

Gly Gly Tyr Ala Gly Ser Ser Ser Asn Phe Leu 
1               5                   10      


<210>  259
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 CA2, CB6, CB12, CC3, CA3, CA10, CA6, CB5, CC4, CD1, CC5

<400>  259

Ser Asn Gly Val Gly 
1               5   


<210>  260
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser 
225                 230                 235             


<210>  261
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CB6

<400>  261

Ser Gly Ser Ser Ser Asn Ile Gly Thr Gly Asn Tyr Val Gly 
1               5                   10                  


<210>  262
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CB6

<400>  262

Gly Ala Val Thr Arg Ala Ser 
1               5           


<210>  263
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CB6, CB7

<400>  263

Ala Ser Tyr Asp Ser Thr Ser Gly Gly Val 
1               5                   10  


<210>  264
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
305                 310                 315                 


<210>  265
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 CA7, CA12

<400>  265

Gly Ser Tyr Tyr His Gly Gly Gly Asn Gly Met Val Asp Phe Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  266
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 CA8

<400>  266

Ser Asn Ala Val Val 
1               5   


<210>  267
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CA8

<400>  267

Ala Ile Asp Lys Asp Gly Asp Thr Ile Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  268
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 CA8

<400>  268

Asp Pro Ser Gly Trp Gly Tyr Pro Asp Val Asp Tyr 
1               5                   10          


<210>  269
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CA8

<400>  269

Ser Gly Thr Tyr Ile Gly Ser Ser Asp Val Gly 
1               5                   10      


<210>  270
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CA8

<400>  270

Gly Thr Ser Ser Arg Pro Ser 
1               5           


<210>  271
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CA8

<400>  271

Ala Thr Tyr Glu Ser Ser Tyr His Asn Ser Val 
1               5                   10      


<210>  272
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 CB10, CA11

<400>  272

Ser Asn Thr Val Ala 
1               5   


<210>  273
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CB10, CA11

<400>  273

Glu Ile Asn Ser Gly Gly Ser Thr Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  274
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 CB10, CA11

<400>  274

Gly Ala Arg Ser Thr Tyr Ala Ala Tyr 
1               5                   


<210>  275
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CB10

<400>  275

Ser Gly Ser Ser Ser Asp Val Gly Tyr Ser Thr Trp Val Tyr 
1               5                   10                  


<210>  276
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CB10

<400>  276

His Ile Ser Asn Arg Ala Ser 
1               5           


<210>  277
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CB10

<400>  277

Ala Ala Tyr Asp Ser Ser Asn Asn Val Trp Ile 
1               5                   10      


<210>  278
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  278

Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp 
1               5                   10              


<210>  279
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 CB7

<400>  279

Asn Tyr Arg Val Gly 
1               5   


<210>  280
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CB7

<400>  280

Asn Ile Arg Ser Gly Gly Thr Thr Trp Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  281
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 CB7

<400>  281

Asp Ser Ser Gly Asp Leu Tyr Ala Tyr Asp Tyr 
1               5                   10      


<210>  282
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CB7

<400>  282

Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asn Tyr Met Ala 
1               5                   10                  


<210>  283
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  283

Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
1               5                   10              


<210>  284
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CC7

<400>  284

Asp Asn Asn Asp Arg Pro Ser 
1               5           


<210>  285
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CC7

<400>  285

Ala Ser Tyr Asp Thr Ser Asn Ile Gly Leu 
1               5                   10  


<210>  286
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 CB12, CC3, CD1

<400>  286

Cys Arg Asp Gly Gly Val Ser Tyr Gly Tyr Asp Val Asp Tyr 
1               5                   10                  


<210>  287
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CB12

<400>  287

Ser Gly Ser Ser Ser Asn Val Gly Gly Asp Tyr Val Gly 
1               5                   10              


<210>  288
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CB12, CA1

<400>  288

Asp Thr Thr Ser Arg Pro Ser 
1               5           


<210>  289
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CB12

<400>  289

Ala Ser Val Asp Lys Thr Thr Gly Gly Val 
1               5                   10  


<210>  290
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CC3, CD1

<400>  290

Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Thr Tyr Val Ser 
1               5                   10                  


<210>  291
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CC3, CD1

<400>  291

Ala Ser Tyr Asp Thr Gly Ser Gly Gly Val 
1               5                   10  


<210>  292
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CC7

<400>  292

Ser Gly Ser Tyr Ile Thr Gly Ser Ser Val Gly 
1               5                   10      


<210>  293
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg 
145                 150                 155 


<210>  294
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  294

Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
1               5                   10                  15      


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
            20                  25                  30          


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
        35                  40                  45              


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
    50                  55                  60                  


Pro Thr Arg Glu Pro Lys Lys Val Ala 
65                  70              


<210>  295
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  295

Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
1               5                   10                  15      


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
            20                  25                  30          


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
        35                  40                  45              


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
    50                  55                  60                  


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
65                  70                  75                  80  


Ser Pro Ser Ser 
                


<210>  296
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CA1

<400>  296

Asp Ile Arg Ala Asp Gly Ala Thr Asn Tyr Asn Ala Ala Leu Lys Ser 
1               5                   10                  15      


<210>  297
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 CA1

<400>  297

Pro Gly Asn Tyr Tyr Tyr Gly Ala Gly Arg Asp Val Ala Arg Leu Ala 
1               5                   10                  15      


Asp 
    


<210>  298
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CA1

<400>  298

Ser Gly Ser Ser Ser Asn Ile Gly Gly Gly Asn Ala Val Gly 
1               5                   10                  


<210>  299
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CA1

<400>  299

Ala Ala Met Asp Ser Ser Ser Leu Ile Gly Val 
1               5                   10      


<210>  300
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  300

Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
1               5                   10                  15      


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
            20                  25                  30          


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
        35                  40                  45              


Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
    50                  55                  60                  


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr 
65                  70                  75              


<210>  301
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CA3

<400>  301

Ser Gly Ser Ser Gly Asn Ile Gly Tyr Asp Asp Tyr Val Ser 
1               5                   10                  


<210>  302
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CA3

<400>  302

Gly Ala Thr Arg Arg Ser Ser 
1               5           


<210>  303
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CA3

<400>  303

Ala Ser Tyr Asp Ser Ser Gly Gly Gly Val 
1               5                   10  


<210>  304
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  304

Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
1               5                   10                  15      


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
            20                  25                  30          


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
        35                  40                  45              


Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
    50                  55                  60                  


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
65                  70                  75                  80  


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
                85                  90                  95      


Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
            100                 105                 110         


Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
        115                 120                 125             


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
    130                 135                 140                 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
145                 150                 155                 160 


Phe Lys Asp Arg Val 
                165 


<210>  305
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CD2

<400>  305

Ser Gly Ser Asn Ile Gly Asp Ala Asp Val Gly 
1               5                   10      


<210>  306
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CD2

<400>  306

Tyr Asn Glu Asn Arg Pro Ser 
1               5           


<210>  307
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CD2

<400>  307

Gly Ser Tyr Ala Gly Asp Thr Tyr Asn His Gly Val 
1               5                   10          


<210>  308
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  308

Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
1               5                   10                  15      


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
            20                  25                  30          


Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
        35                  40                  45              


Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
    50                  55                  60                  


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
65                  70                  75                  80  


Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
                85                  90                  95      


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
            100                 105                 110 


<210>  309
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  309

Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
1               5                   10                  15      


Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
            20                  25                  30          


Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
        35                  40                  45              


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
    50                  55                  60                  


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
65                  70                  75                  80  


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn 
                85                  90                  


<210>  310
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 CG11, CE2/E1B8

<400>  310

Asn Tyr Pro Val Gly 
1               5   


<210>  311
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CG11, CE2/E1B8

<400>  311

Asn Ile Glu Asn Asp Gly Ser Ala Asn Tyr Ala Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  312
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 CG11, CE2/E1B8

<400>  312

Glu Phe Gly Gly Ser Asp Gly Tyr Thr Tyr Phe Val Asp Ile Asp Tyr 
1               5                   10                  15      


<210>  313
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CG11, CE2/E1B8

<400>  313

Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asn Tyr Val Ser 
1               5                   10                  


<210>  314
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CG11, CE2/E1B8

<400>  314

Ala Ser Tyr Asp Gly Ser Ser Ser Gly Val 
1               5                   10  


<210>  315
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  315

Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly 
1               5                   10                  15      


Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile 
            20                  25                  30          


Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
        35                  40              


<210>  316
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CA10

<400>  316

Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asn Tyr Val Thr 
1               5                   10                  


<210>  317
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CA10

<400>  317

Asp Ala Thr Thr Arg Val Ser 
1               5           


<210>  318
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CA10

<400>  318

Ala Ala His Asp Ser Ser Ser Gly Gly Val 
1               5                   10  


<210>  319
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  319

Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys 
1               5                   10              


<210>  320
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2/E1B8 general epitope


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  Where X is any amino acid

<400>  320

Xaa Xaa Xaa Xaa Gly Ser Leu Gly Asn Ile Xaa Xaa Xaa 
1               5                   10              


<210>  321
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  321

Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
1               5                   10                  15      


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
            20                  25                  30  


<210>  322
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  322

Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
1               5                   10                  15      


Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
            20                  25                  30          


Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
        35                  40              


<210>  323
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CA6

<400>  323

Asp Lys Ser Ser Gly Gly Lys Thr Tyr Gly Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  324
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CA6

<400>  324

Ser Gly Ser Arg Asn Asn Ile Gly Tyr Gly Asn His Val Gly 
1               5                   10                  


<210>  325
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CA6

<400>  325

Ala Ser Phe Asp Arg Gly Ser Gly Gly Ile 
1               5                   10  


<210>  326
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  326

Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
1               5                   10                  15      


Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
            20                  25                  30          


Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys 
        35                  40                  45              


Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val 
    50                  55                  60                  


Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
65                  70                  75                  80  


Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                85                  90                  


<210>  327
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CA11

<400>  327

Ser Gly Ser Gly Ser Asn Ile Gly Ala Gly Asn Trp Val Ser 
1               5                   10                  


<210>  328
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CA11

<400>  328

Gly Ala Thr Ser Arg Pro Ser 
1               5           


<210>  329
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CA11

<400>  329

Ala Ala Tyr Asp Ser Gly Ser Ser Ile Val 
1               5                   10  


<210>  330
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  330

Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
1               5                   10              


<210>  331
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 general epitope


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  Where X is any amino acid

<400>  331

Xaa Xaa Xaa Asp Xaa Ile Thr His Xaa Pro Xaa Xaa Xaa 
1               5                   10              


<210>  332
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  332

Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His 
1               5                   10                  15      


Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
            20                  25                  30          


Glu 
    


<210>  333
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  333

Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys 
1               5                   10                  15      


Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
            20                  25                  30      


<210>  334
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 CB3

<400>  334

Ser Val Ala Val Asn 
1               5   


<210>  335
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CB3

<400>  335

Gly Ile Ile Ser Asn Gly Gly Thr Gly Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  336
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 CB3

<400>  336

Gly Val Glu Trp Glu Gly Ser Met Asp Tyr 
1               5                   10  


<210>  337
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CB3

<400>  337

Ser Gly Ser Ser Ser Asn Val Gly Ala Gly Ser Tyr Val Gly 
1               5                   10                  


<210>  338
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CB3

<400>  338

Gly Ala Thr Lys Arg Ala Ser 
1               5           


<210>  339
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CB3

<400>  339

Val Ser Tyr Gln Thr Asp Phe Thr Leu Val 
1               5                   10  


<210>  340
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  340

Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
1               5                   10                  15      


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
            20                  25                  30          


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
        35                  40                  45              


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
    50                  55                  60                  


Ser 
65  


<210>  341
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CB5

<400>  341

Asp Ile Thr Ser Gly Gly Arg Thr Tyr Gly Asn Leu Ala Leu Lys Ser 
1               5                   10                  15      


<210>  342
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CB5

<400>  342

Ser Gly Ser Ser Ser Asn Val Gly Ser Gly Asp His Val Asn 
1               5                   10                  


<210>  343
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 CB5

<400>  343

Arg Thr Thr Asn Arg Ala Ser 
1               5           


<210>  344
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CB5

<400>  344

Ala Ser His Asp Asn Asn Ser Gly Gly Val 
1               5                   10  


<210>  345
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  345

Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
1               5                   10                  15      


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
            20                  25                  30          


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
        35                  40                  45              


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
    50                  55                  60                  


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
65                  70                  75                  80  


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
                85                  90                  95      


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg 
            100                 105         


<210>  346
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 CC4

<400>  346

Ser Gly Ser Ser Ser Asn Val Gly Tyr Thr Asn Leu Gly Tyr Ser Asn 
1               5                   10                  15      


Leu Val Thr 
            


<210>  347
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CC4

<400>  347

Ala Ser Tyr Asp Ser Ser Asn Gly Gly Ile 
1               5                   10  


<210>  348
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  348

Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
1               5                   10                  15      


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
            20                  25                  30          


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
        35                  40                  45              


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
    50                  55                  60                  


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
65                  70                  75                  80  


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
                85                  90                  95      


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
            100                 105                 110         


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
        115                 120                 125             


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
    130                 135                 140                 


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
145                 150                 155                 160 


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
                165                 170                 175     


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser 
            180                 185                 190 


<210>  349
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 CC5

<400>  349

Asp Ile Ser Ser Val Gly Lys Lys Tyr Ala Ser Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  350
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 CC5

<400>  350

Ala Ser Tyr Asp Ser Ser Asn Gly Gly Val 
1               5                   10  


<210>  351
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  351

Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys 
1               5                   10              


<210>  352
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 MD9

<400>  352

Ser Gly Ser Ser Ser Asn Val Gly Ile Tyr Asp Val Ser 
1               5                   10              


<210>  353
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 MD9

<400>  353

Gly Thr Asn Asn Arg Pro Ser 
1               5           


<210>  354
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 MD9

<400>  354

Ala Ala Gly Asp Ser Ser Thr Ile Ala Val 
1               5                   10  


<210>  355
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  355

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30      


<210>  356
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  356

Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
1               5                   10                  15      


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
            20                  25                  30          


<210>  357
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 NS1G7

<400>  357

Ser Tyr Gly Val Gly 
1               5   


<210>  358
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 NS1G7

<400>  358

Ser Ile Ser Ser Gly Gly Thr Thr Phe Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  359
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 NS1G7

<400>  359

Asp Val His Ile Tyr Tyr Asn Asp Tyr Gly Ala Ala Tyr Gly Asp Arg 
1               5                   10                  15      


Asp Tyr 
        


<210>  360
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 NS1G7

<400>  360

Ser Gly Ser Ser Ser Asn Ile Gly Gly Gly Asn Tyr Val Ser 
1               5                   10                  


<210>  361
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 NS1G7

<400>  361

Gly Thr Thr Ser Arg Ala Ser 
1               5           


<210>  362
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 NS1G7

<400>  362

Ala Ser Tyr Asp Thr Asn Ser Gly Ser Val 
1               5                   10  


<210>  363
<211>  244
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA2 amino acid sequence

<400>  363

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Val 
            20                  25                  30          


Ala Val Asn Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Ile Ser Asn Gly Gly Thr Gly Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ala Leu Thr His Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Gly Val Glu Trp Glu Gly Ser Met Asp Tyr Leu Gly Pro Gly Leu 
            100                 105                 110         


Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu 
        115                 120                 125             


Thr Lys Val Asp Asp Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser 
    130                 135                 140                 


Gly Phe Leu Gly Gln Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser 
145                 150                 155                 160 


Asn Val Gly Ala Gly Ser Tyr Val Gly Trp Tyr Gln Gln Val Pro Gly 
                165                 170                 175     


Ser Gly Leu Arg Ile Leu Ile Tyr Gly Ala Thr Lys Arg Ala Ser Gly 
            180                 185                 190         


Leu Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val 
    210                 215                 220                 


Ser Tyr Gln Thr Asp Phe Thr Leu Val Phe Gly Ser Gly Thr Arg Leu 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  364
<211>  245
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 amino acid sequence

<400>  364

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Arg Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Arg Ser Gly Gly Thr Thr Trp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Ala Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ser Ser Gly Asp Leu Tyr Ala Tyr Asp Tyr Trp Gly Pro Gly 
            100                 105                 110         


Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ala Ser Gly 
        115                 120                 125             


Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr Gln Pro Ser Ser Val 
    130                 135                 140                 


Ser Arg Ser Leu Gly Gln Ser Val Ser Met Thr Cys Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Asn Val Gly Tyr Gly Asn Tyr Met Ala Trp Phe Gln Gln Val Pro 
                165                 170                 175     


Gly Ser Ala Pro Lys Leu Leu Ile Tyr Gly Ala Thr Ser Arg Ala Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ser Tyr Asp Ser Thr Ser Gly Gly Val Phe Gly Ser Gly Thr Arg 
225                 230                 235                 240 


Leu Thr Val Leu Gly 
                245 


<210>  365
<211>  244
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 amino acid sequence

<400>  365

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ala Val Ile Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asp Val Asp Gly Asp Ala Ala Tyr Asp Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Ser Trp Gly Tyr Val Ser Asp Ile Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ala 
        115                 120                 125             


Ser Gly Glu Ser Lys Val Asp Asp Arg Val Val Arg Thr Gln Pro Ser 
    130                 135                 140                 


Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile Thr Cys Ser Gly 
145                 150                 155                 160 


Ser Tyr Ile Thr Gly Ser Ser Val Gly Trp Phe Gln Gln Val Pro Gly 
                165                 170                 175     


Ser Gly Leu Lys Thr Val Ile Tyr Asp Asn Asn Asp Arg Pro Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr Ala Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Tyr Asp Thr Ser Asn Ile Gly Leu Phe Gly Ser Gly Thr Arg Leu 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  366
<211>  250
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2/E1B8 amino acid sequence

<400>  366

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Pro Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Glu Asn Asp Gly Ser Ala Asn Tyr Ala Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Ala Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Glu Phe Gly Gly Ser Asp Gly Tyr Thr Tyr Phe Val Asp Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser 
        115                 120                 125             


Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr 
    130                 135                 140                 


Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln Ser Val Ser Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asn Tyr Val Ser Trp 
                165                 170                 175     


Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Ile Leu Ile Tyr Gly Ala 
            180                 185                 190         


Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Thr Ser Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Gly Ser Ser Ser Gly Val Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 250 


<210>  367
<211>  250
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 amino acid sequence

<400>  367

Gln Val Arg Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Ala Gly Cys Ser Ser Asp Gly Lys Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Tyr Tyr Pro Val Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser 
        115                 120                 125             


Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr 
    130                 135                 140                 


Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Ser Ser Ser Asn Val Gly Arg Asn Asp Val Ala Trp Phe 
                165                 170                 175     


Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Tyr Gly Thr Thr 
            180                 185                 190         


Ser Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
        195                 200                 205             


Val Thr Ala Thr Leu Thr Ile Asp Ser Leu Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Phe Cys Ala Ser Gly Asp Ser Ser Ala Ile Asn Asp Ile Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 250 


<210>  368
<211>  234
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 amino acid sequence

<400>  368

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val Tyr Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Ile 
        35                  40                  45              


Ser Ile Met Tyr Ala Ser Gly Arg Val Asp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Ile Glu Asn Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
            100                 105                 110         


Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Asp 
        115                 120                 125             


Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Thr Glu 
    130                 135                 140                 


Arg Val Ser Ile Thr Cys Arg Thr Ser Gln Ser Val Asn Asn Tyr Leu 
145                 150                 155                 160 


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr 
                165                 170                 175     


Tyr Ala Thr Arg Leu Tyr Thr Asp Val Pro Ser Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Thr Ser Leu Glu Ala Asp 
        195                 200                 205             


Asp Thr Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Leu Ala 
    210                 215                 220                 


Phe Gly Gly Gly Thr Asn Val Glu Ile Lys 
225                 230                 


<210>  369
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB2 amino acid sequence

<400>  369

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Phe Asn Pro Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Asn Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Ser Tyr Arg Thr Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Ile Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Gly Ser Pro Gly Gln Thr Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Tyr Ile Gly Ser Ser Gly Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Met Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Leu Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 


<210>  370
<211>  244
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB3 amino acid sequence

<400>  370

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Val 
            20                  25                  30          


Ala Val Asn Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Ile Ser Asn Gly Gly Thr Gly Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ala Leu Thr His Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Gly Val Glu Trp Glu Gly Ser Met Asp Tyr Leu Gly Pro Gly Leu 
            100                 105                 110         


Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu 
        115                 120                 125             


Thr Lys Val Asp Asp Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser 
    130                 135                 140                 


Gly Phe Leu Gly Gln Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser 
145                 150                 155                 160 


Asn Val Gly Ala Gly Ser Tyr Val Gly Trp Tyr Gln Gln Val Pro Gly 
                165                 170                 175     


Ser Gly Leu Arg Ile Leu Ile Tyr Gly Ala Thr Lys Arg Ala Ser Gly 
            180                 185                 190         


Leu Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val 
    210                 215                 220                 


Ser Tyr Gln Thr Asp Phe Thr Leu Val Phe Gly Ser Gly Thr Arg Leu 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  371
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA9 amino acid sequence

<400>  371

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Ser Tyr Arg Ser Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Met Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 


<210>  372
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA12 amino acid sequence

<400>  372

Gln Val Gln Leu Gln Gly Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Phe Asp Ser Tyr 
            20                  25                  30          


Tyr Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Asn Ile Tyr Ser Thr Gly Arg Ala Phe Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Val Ser Ser Val Thr Ile Glu Asp Thr Ala Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Ser Tyr Tyr His Gly Gly Gly Asn Gly Met Val Asp Phe Phe 
            100                 105                 110         


Asp Tyr Trp Ser Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Val Val Arg 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asn Tyr Val Gly 
                165                 170                 175     


Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg 
        195                 200                 205             


Ser Gly Asn Thr Ala Thr Leu Thr Ile Asp Ser Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gln Arg Gly Asn Thr Gly Val 
225                 230                 235                 240 


Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 250     


<210>  373
<211>  240
<212>  PRT
<213>  artificial sequence

<220>
<223>  MD9 amino acid sequence

<400>  373

Gln Val Arg Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Arg Glu 
            20                  25                  30          


Ser Ile Ala Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Gly Val Gly Ile Asp Gly Thr Ser Tyr Tyr Ser Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Ala Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Ala Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Tyr Ile Asp Phe Glu Tyr Trp Gly Pro Gly Leu Leu Val Thr 
            100                 105                 110         


Val Ser Ser Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser Lys Val 
        115                 120                 125             


Asp Asp Gln Ala Val Leu Thr Gln Leu Ser Ser Val Ser Gly Ser Leu 
    130                 135                 140                 


Gly Gln Arg Ile Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly 
145                 150                 155                 160 


Ile Tyr Asp Val Ser Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg 
                165                 170                 175     


Thr Val Ile Tyr Gly Thr Asn Asn Arg Pro Ser Gly Val Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Ser Glu Asp Glu Ala Ile Tyr Tyr Cys Ala Ala Gly Asp Ser 
    210                 215                 220                 


Ser Thr Ile Ala Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
225                 230                 235                 240 


<210>  374
<211>  252
<212>  PRT
<213>  artificial sequence

<220>
<223>  NS1G7 amino acid sequence

<400>  374

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Ser Ser Gly Gly Thr Thr Phe Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Glu Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Val His Ile Tyr Tyr Asn Asp Tyr Gly Ala Ala Tyr Gly Asp 
            100                 105                 110         


Arg Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly 
        115                 120                 125             


Lys Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val 
    130                 135                 140                 


Val Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Arg Val Ser 
145                 150                 155                 160 


Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Gly Asn Tyr Val 
                165                 170                 175     


Ser Trp Tyr Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Leu Ile Tyr 
            180                 185                 190         


Gly Thr Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Thr Asn Ser Gly Ser 
225                 230                 235                 240 


Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 250         


<210>  375
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  375

Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
1               5                   10                  15      


Arg Val Gln Ser Lys 
            20      


<210>  376
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  376

Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
1               5                   10          


<210>  377
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  377

Ser Leu Asp Asn Ile Thr His Val Pro 
1               5                   


<210>  378
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  378

Val Gln Ile Val Tyr Lys Pro Val Asp 
1               5                   


<210>  379
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  379

Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
1               5                   10  


<210>  380
<211>  753
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1D12 nucleotide sequence

<400>  380
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattgaac aacaatgctg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtc gcttgtgggt tgtagcagtg atggaacgtg ttactataat      180

tcggccctga aatcccggct cgacatcacc agggacacct ccaagaacca gatctccctg      240

tcactgagca gcgttacaac tgacgacgcg gccgtgtact attgtacaag aggccattat      300

agtatttatg gttatgacta tcttggcact atcgactact ggggcccagg actcctggtc      360

accgtctcct cagaaggtaa atcttctggc gcgtctggcg agtctaaagt ggatgaccag      420

gctgtgctga ctcagccgtc ctccgtgtcc gggtccctgg gccagagggt ctccatcacc      480

tgctctggaa gcagcagcaa cgtcgggggt ggtaatagtg tgggctggta ccaacacctc      540

ccaggctcag gcctcaaaac catcatctat gatactaaca gtcgaccctc gggggtcccg      600

gaccgattct ctggctccag gtctggcaac acggccaccc taaccatcaa ctcgctccag      660

gctgaggacg agggtgatta ttactgtgta acgggtgaca gcactactca tgatgatctt      720

gtcggcagcg ggaccaggct gaccgtcctg ggg                                   753


<210>  381
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1G2 nucleotide sequence

<400>  381
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc agcaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctataat      180

ccagccctta actcccggct cagcatcacc agggacacct ccaagagtca agtctctttg      240

tcattgagca gcgtgacaag tgaggacacg gccgtgtact actgtggaag aagttatagg      300

gctgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcaccgtct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

caggccgtgg tgactcagcc gtcctccgtg tctgggtccc tgggccagag ggtctccatc      480

acctgctctg gaagcttcat cggtattagt agtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccatcat cgtggcgagt gacggtcgac cctcaggggt ccccgaccga      600

ttctctatgt ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc cttatactgg ggtcttcggc      720

agcgggacca ggctgaccgt cctgggt                                          747


<210>  382
<211>  705
<212>  DNA
<213>  artificial sequence

<220>
<223>  CA4 nucleotide sequence

<400>  382
caggttcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc agctattccg tatactgggt ccgccaggct      120

ccaggccagg cactggagtg gattagtatt atgtatgcta gtggaagagt agactataac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagtca attctccctg      240

tcattgagca gcgtgacaac tgaggacacg gccgtctact actgtacaag aggaatcgaa      300

aactggggcc ccggactcct ggtcaccgtc tcctcagaag gtaaatcttc tggcgcgtct      360

ggcgagtcta aagtggatga cgacatccag gtgacccagt ctccgtcctc cctgtctgca      420

tctctaacag agagagtctc catcacttgc cggaccagtc agagcgttaa caattactta      480

agctggtatc agcagaaacc agggcaagct cctaagctcc tgatctatta tgcaaccaga      540

ttgtacaccg atgtcccatc ccggttcagt ggcagtggat ctgggacaga ttacaccctc      600

accatcacca gcctggaggc ggacgacact gcaacttatt actgtctaca atatgatagt      660

acacctcttg cattcggcgg tgggaccaac gtggaaatca aacgg                      705


<210>  383
<211>  750
<212>  DNA
<213>  artificial sequence

<220>
<223>  CE2 nucleotide sequence

<400>  383
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc aactatcctg taggctgggt ccgccaggct      120

ccaggaaagg cactggagtg gattggtaac atagaaaatg atggaagtgc gaactatgcc      180

tcggccctga aatcccgact cagcatcacc agggacacct ccaagaacca agtctccctg      240

tcactgagca gcgcgacaac tgaggacacg gccgtttact actgtggaag agaattcggt      300

gggagtgatg gttatactta tttcgttgat atcgactact ggggcccagg actcctggtc      360

accgtctcct cagaaggtaa atcttctggc gcgtctggcg agtctaaagt ggatgaccag      420

gctgtgctga ctcagccgtc ctccgtgtcc aagtccctgg gccagagtgt ctccatcacc      480

tgctctggaa gcagcagcaa cgttggatat ggtaattatg tgagctggtt ccaacaggtc      540

ccaggatcag cccccaaaat cctcatctat ggtgcaacca gtcgagcctc gggggtcccc      600

gaccgattct ccggctccag gtctggcaac acagcgactc tgaccatcac ctcgctccag      660

gctgaggacg aggccgatta ttactgtgca tcttatgacg gcagtagcag tggtgttttc      720

ggcagcggga ccaggctgac cgtcctgggt                                       750


<210>  384
<211>  750
<212>  DNA
<213>  artificial sequence

<220>
<223>  CE3 nucleotide sequence

<400>  384
caggtgcgac tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccgtc       60

acctgcacgg tctctggatt ctcattgatc agcaatgctg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtc gcttgctggt tgtagcagtg atggaaagtg ttactataac      180

tcggccctga aatcccggct cgacatcacc agggacacct cgaagaacca gatctccctg      240

tcactgagca gcgtcacaac tgacgacgcg gccgtgtact actgtacaag aggctattat      300

cctgtttatg gttatgacta tcttggcact atcgactact ggggccccgg actcctggtc      360

accgtctcct cagaaggtaa atcttctggc gcgtctggcg agtctaaagt ggatgaccaa      420

gctgtgctga ctcaaccgtc ctccgtgtct gggtccctgg gccagagggt ctccatcacc      480

tgctctggaa gcagcagcaa cgttggtaga aatgatgtag cctggttcca acaactccca      540

ggatcaggcc tcagaaccat catctatggt actaccagtc gaccctcagg tatcccggac      600

cgattctccg gctccaagtc tggcgttacg gccaccctga ccatcgactc gctccaggct      660

gaggacgagg ccgattattt ctgtgcctct ggtgacagta gtgccattaa tgatattttc      720

ggcagcggga ccaggctgac cgtcctgggt                                       750


<210>  385
<211>  735
<212>  DNA
<213>  artificial sequence

<220>
<223>  CB7 nucleotide sequence

<400>  385
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc aactatcgtg taggttgggt ccgccaggct      120

ccaggaaagg cactggagtg ggttagtaac atacggagtg gtggaactac atggtataac      180

ccggccctga aatcccggct cagcatcacc gcggacacct ccaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggacacg gccgtatatt attgtgcaag agattcctct      300

ggtgatcttt atgcgtatga ttactggggc ccaggactcc tggtcaccgt ctcctcagaa      360

ggtaaatctt ctggcgcgtc tggcgagtct aaagtggatg accaggccgt gctgactcag      420

ccgtcctccg tgtccaggtc cctgggccag agtgtctcca tgacctgctc tggaagcagc      480

agcaacgttg gatatggtaa ttatatggcc tggttccaac aggttccagg atcagccccc      540

aaactcctca tctatggtgc aaccagtcga gcctcggggg tccccgaccg attctccggc      600

tccaggtctg gcaacacagc gactctgacc atcagctcgc tccaggctga ggacgaggcc      660

gattactact gtgcatctta tgacagcact agcgggggtg tcttcggcag cgggaccagg      720

ctgaccgtcc tgggt                                                       735


<210>  386
<211>  732
<212>  DNA
<213>  artificial sequence

<220>
<223>  CC7 nucleotide sequence

<400>  386
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcactaacc agcaatgctg tgatctgggt ccggcaggct      120

ccaggaaagg cgccggagtg ggttgctttg atagatgttg atggagatgc agcctatgac      180

ccagccctta agtcccgcct cagcatcacc agggacacct ccaagagtca agtctccctt      240

tcactgcgca gcgtgacaac tgaggacacg gccgtgtact actgtgcaag agactatggt      300

agttggggtt atgtttccga catcgactac tggggcccag gactcctggt caccgtctcc      360

tcagaaggta aatcttctgg cgcgtctggc gagtctaaag tggatgacag ggtcgtgcgg      420

actcaaccgt cctccgtgtc tgggtccctg ggccagaggg tctccatcac ctgctctgga      480

agctacatca ctggtagttc tgtaggctgg ttccaacagg tcccaggatc gggcctcaaa      540

accgtcatct atgacaataa cgatcgaccc tcaggggtcc ccgaccgatt ctctggctcc      600

aagtcgggcg acacagccac cctgaccatc agctcgctcc aggctgagga cgaggccgat      660

tattactgtg catcttatga caccagtaac attggtcttt tcggcagcgg gaccaggctg      720

accgtcctgg gt                                                          732


<210>  387
<211>  723
<212>  DNA
<213>  artificial sequence

<220>
<223>  412E10 nucleotide sequence

<400>  387
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggctt ctctgtaata agcgattctg tagcctgggt ccgccaggct      120

ccaggaaaag tgccggagtg gcttggtgct agcggcagtt ctggaaacaa atactataac      180

ccggccctaa aatcccggct cagcatcacc agggacacct ccaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggatacg gccgtgtact actgtgcgag aggtattatc      300

gccggtgtag atgtctgggg ccgaggactc ctggtcaccg tctcctcaga aggtaaatct      360

tctggcgcgt ctggcgagtc taaagtggat gaccaggctg tgctgactca gccgtcctcc      420

gtgtctgggt ccctgggcca gagggtctcc atcacctgct ctggaagcag cagcaacgtt      480

ggatatggta attatgtggg ctggtaccaa caggtcccag gatcagcccc caaactcctc      540

atctatggta cagccattcg agcctcgggg gtccccgacc gattctccgg ctccaggtct      600

ggggacacag ccacccttac catcacctcg ctccaggctg aggacgaggc cgattactac      660

tgtgcatctt atcagagtaa ttacgctttt ttcggcagcg ggaccaggct gaccgtcctg      720

ggt                                                                    723


<210>  388
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1B1 nucleotide sequence

<400>  388
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattgtcc agcaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctataat      180

ccagccctta actcccggct cagcatcacc agggacacct ccaagagtca agtctctttg      240

tcattgagca gcgtgacaag tgaggacacg gccgtgtact actgtgtaag aagttatagg      300

actgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcaccgtct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

caggctgtgc tgactcagcc gtcctccgtg tctgggtccc tgggccagag ggtctccatc      480

acctgctctg gaagcttcat cggtattagt agtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccgtcat cgttgcgagt gacggtcgac cctcaggggt ccccgaccga      600

ttctctaact ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc aatatactgg agttttcggc      720

agcgggacca ggctgaccgt ccttggt                                          747


<210>  389
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1D9 nucleotide sequence

<400>  389
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc agcaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatagtg atggagaaga aggctataat      180

ccagccctta actcccggct cagcatcacc agggacacct ccaagaatca agtctctttg      240

tcattgagca gagtgacaag tgaggacacg gccgtttact actgtggaag aacttatagg      300

actgatggtt atgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcaccgtct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

cgggtcatgc tgactcagcc accctccgtg tccgggtccc cgggccagac ggtatccatc      480

acctgctctg gaagcttcat cggtattagt agtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccgtcat ttttgcgagt gacggtcgac cctcaggggt ccccgatcga      600

ttctctaact ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc aatatactgg agttttcggc      720

agcgggacca ggctgaccgt cctgagt                                          747


<210>  390
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1F4 nucleotide sequence

<400>  390
caggtgcagt tgcaagagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaagt agcaattctg tcggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctataat      180

ccagccctta actcccggct cagcatcacc agggacacct ccaagagtca agtctcattg      240

tcattgagca gcgttacaag tgaggacacg gccgtgtact actgtgtaag aagttataga      300

gctgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

ctcaccatct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

caggccgtgg tgactcagcc gtcctccgtg tctgggtccc tgggccagag ggtctccatc      480

acctgctctg gaagcttcat cggtattagt agtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccgtcat cgtggcgagt gacggtcgac cctcaggggt ccccgaccga      600

ttctctaact ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc aatatactgg agttttcggc      720

agcgggacca ggctgaccgt cctgggt                                          747


<210>  391
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1G10 nucleotide sequence

<400>  391
caggttcagt tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc agcaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctataat      180

ccagccctta actcccggct cagcatcacc agggacacct ccaagagtca agtctcattg      240

tcattgagca gcgtgacaag tgaggacacg gccgtgtact actgtggaag aagttataga      300

gctgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcaccgtct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

caggctgtgc tgactcagcc gtcctccatg tccgggtccc tgggccagag ggtctccatc      480

acctgttctg gaagcttcat cggtattagt agtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccatcat cgtggcgagt gacggtcgac cctcaggggt ccccgaccga      600

ttctctatgt ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc aatatactgg agttttcggc      720

agcgggacca ggctgaccgt cctgggt                                          747


<210>  392
<211>  750
<212>  DNA
<213>  artificial sequence

<220>
<223>  S2C6 nucleotide sequence

<400>  392
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaatc agcaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctataat      180

ccagccctta agtcccaata tgcagctagt gatccggaca cctccaagag tcaagtctcc      240

ttgtcattga gcagcgtgac aagtgaggac acggccgtgt actactgtgg aagaacttat      300

aggactgatg gttttgctta tggttatgtc caagccatcg actactgggg cccaggactc      360

ctgctcacta tctcctcaga aggtaaatct tctggcgcgt ctggcgagtc taaagtggat      420

gaccaggctg tgctgactca gccgtcctcc gtgtctgggt ccctgggcca gagggtctcc      480

atcacctgct ctggaagctt tattggtatt agtagtgtag gctggttcca acagctccca      540

ggatcgggcc tcagaaccat catcgtggcg agtgacggtc gaccctcagg ggtccccgac      600

cgattctcta tgtccaaatc gggcaacaca gccaccctga ccatcagctc gctccaggct      660

gaggacgagg ccgattattt ctgtggaagt agtgatagga ctcaatatac tggagttttc      720

ggcagcggga ccaggctgac cgtcctgggt                                       750


<210>  393
<211>  720
<212>  DNA
<213>  artificial sequence

<220>
<223>  MD9 nucleotide sequence

<400>  393
caggtgcggc tgcaggagtc gggacccagc ctggtgaagt cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc agggaatcta tagcctgggt ccgccaggct      120

ccaggaaagg tgccggagtg gcttggtggt gtaggcattg atggaacctc atactatagc      180

ccggccctga aatcccggct cagtatcacg agggacacct ccaagagcca agcctccctg      240

tcactgagca gcgtggcaac tgaggacacg gccatgtatt actgtgcacg taattatatt      300

gatttcgagt actggggccc aggactcctg gtcaccgtct cctcagaagg taaatcttct      360

ggcgcgtctg gcgagtctaa agtggatgac caggctgtgc tgactcaact gtcctccgta      420

tctgggtccc tgggccagag gatctccatc acctgctctg gaagcagcag caacgttggt      480

atatatgatg tgtcttggtt ccaacaactc ccaggatcag gcctcagaac cgtcatctat      540

ggtactaaca atcgaccctc gggtgtcccg gaccgattct ccggctccag gtctggcaac      600

acggccaccc tgactatcag ctctctccag tctgaggacg aggccattta ttactgtgct      660

gctggtgaca gcagtactat tgctgttttc ggcagcggga ccaggctgac cgtcctgggt      720


<210>  394
<211>  726
<212>  DNA
<213>  artificial sequence

<220>
<223>  412B9 nucleotide sequence

<400>  394
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctctgtaata agcgattctg tagcctgggt ccgccaggct      120

ccaggaaaag tgccggagtg gcttggtgct agcggcagtt ctggaaacaa atactataac      180

ccggccctaa aatcccggct cagcatcacc agggacacct ccaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggatacg gccgtgtact actgtgcgag aggtattatc      300

gccggtgtag atgtctgggg ccgaggactc ctggtctccg tctcctcaga aggtaaatct      360

tctggcgcgt ctggcgagtc taaagtggat gaccaggctg tgctgactca gccgtcctcc      420

gtgtctgggg ccctgggcca gagggtctcc atcacctgct ctggaagcag cagcaacgtt      480

ggatatggtg attatgtggg ctggtaccaa caggtcccag gatcagcccc caaactcctc      540

atctatggtg cagccagtcg agcctcgggg gtccccgacc gattctctgg ctccaggtct      600

ggcaacacag cgactctgac catcagctcg ctccaggctg aggacgaggc cgattattac      660

tgtgcatctt atgacagcag tgacggtggt gttttcggca gcgggaccag gctgaccgtc      720

ctgggt                                                                 726


<210>  395
<211>  729
<212>  DNA
<213>  artificial sequence

<220>
<223>  412E6 nucleotide sequence

<400>  395
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcagagac cctctccctc       60

acctgcacgg tctctggatt ctcattaaca aactatggtg tgggctgggt ccgccaggct      120

ccaggaaagg cactggagtg gcttggtaac atatatagtg gtgggtctac atactataac      180

ccggccctga aatcccgact cagcatcacc agggacacct ccaagagcca agtctccctg      240

tcactgaaca gcgtgacact tgaggacacg gccgtttatt actgtggaag aggaggtgtt      300

gggagtgtcg acgtctgggg cccaggactc ctggtcaccg tctcctcaga aggtaaatct      360

tctggcgcgt ctggcgagtc taaagtggat gaccaggctg tgctgactca gccgccctcc      420

gtgtccggtt ccccaggcca gagggtctcc atcacctgct ctggaggcag gaataacatc      480

gggcgtggta cctttgtgga ctggtaccag caactcccag gatcaggcct caaaaccgtc      540

atctatggta ctgaccgtcg accaccgggg gtcccggacc gattctccgg ctccaagact      600

ggcaacgcgg ccaccctgac catcacctcc ctccaggctg aggacgaggc cgattattgg      660

tgtgctactt atgattacag taatgatatg attattctcg gcagcgggac caggctgacc      720

gtcctgggt                                                              729


<210>  396
<211>  714
<212>  DNA
<213>  artificial sequence

<220>
<223>  412G11 nucleotide sequence


<220>
<221>  misc_feature
<222>  (522)..(522)
<223>  n is a, c, g, or t

<400>  396
caggtgcggc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgtacgg tctctggatt ctcattaacc agctatgctt taggctgggt ccgccaggct      120

ccaggaaggg ctccggagtg gattggtaac atatggaggg gtggacgaat agaatataac      180

ccggccctga aatcccggct cagcatcact agggacacct ccaagagcca agtctcgctg      240

tcactgagca gcgtgacaac tgaggatacg gccgtgtact actgttcaag aagtggcggc      300

gactggggcc caggactcct ggtcaccgtc tcctcagaag gtaaatcttc tggcgcgtct      360

ggcgagtcta aagtggatga ccaggctgtg ctgactcagc cgtcctccgt gtctgggtcc      420

ctgggccaga gggtctccat cacctgctct ggaagcagca gcaacgttgg atatggtaat      480

tatgtgggct ggtaccaaca ggtcccagga tcagccccca anctcctcat ctatggtgca      540

accagtcgag cctcgggggt ccccgaccga ttctccggct ccaggtctga gaacacagcc      600

accctgacca tcagctccct ccaggctgag gacgaggccg attattactg tgcgtcttat      660

gataggagtg agagtgttgt gttcggcagc gggaccagac tgaccgtcct gggt            714


<210>  397
<211>  732
<212>  DNA
<213>  artificial sequence

<220>
<223>  CA2 nucleotide sequence

<400>  397
caggttcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaagc agcgtcgctg taaactgggt ccgccaggct      120

ccaggaaagg tgccggagtg gcttggtggc attattagta atggaggcac aggctataat      180

ccggccctga aatctcggct gagcatcacc agggacacct ccaagagcca agtctccctg      240

gcactgaccc acgtgacaac tgaggacacg gccgtgtact actgtggaag gggagttgaa      300

tgggagggct ctatggacta cttgggccca ggactcctgg tcaccgtctc ctcagaaggt      360

aaatcttctg gctctggctc tgagactaaa gtggatgacc agtctgtgct gactcagccg      420

tcctccgtgt ccgggttcct gggccagagg gtcaccatca cctgctctgg aagcagcagc      480

aacgttggag ctggtagtta tgtgggctgg taccagcagg tcccaggatc gggcctcaga      540

atcctcatct atggtgcaac caagcgagcc tcgggactcc ccgaccgatt ctccggctcc      600

aggtctggga acacagccac cctgaccatc agctcgctcc aggctgagga cgaggccgat      660

tattactgcg tatcttatca gactgatttt actttagttt tcggcagcgg gaccaggctg      720

accgtcctag gt                                                          732


<210>  398
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  CA9 nucleotide sequence

<400>  398
caggtgcagc ttcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc agcaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctataat      180

ccagccctta actcccggct cagcatcacc agggacacct ccaagagtca agtctctttg      240

tcattgagca gcgtgacaag tgaggacacg gccgtgtact actgtggaag aagttatagg      300

agtgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcaccgtct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

caagctgtgc tgactcagcc ggcctccgtg tctgggtccc tgggccagag ggtctccatc      480

acctgttctg gaagcttcat cggtattagt agtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccatcat cgtggcgagt gacggtcgac cctcaggggt ccccgaccga      600

ttctctatgt ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc aatatactgg agttttcggc      720

agcgggacca ggctgaccgt cctgggt                                          747


<210>  399
<211>  753
<212>  DNA
<213>  artificial sequence

<220>
<223>  CA12 nucleotide sequence

<400>  399
caggtgcagc tgcaggggtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcttttgac agctattatg taggctgggt ccgccaggct      120

ccaggaaagg cactggagtg gcttggtaat atatatagta ctggaagggc attctataac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagcca agtctcccta      240

tcagtgagca gcgtgacaat tgaggacacg gccctgtact actgtgtcag aggctcgtat      300

tatcacggtg gtggcaatgg gatggtcgac tttttcgact actggagccc aggactcctg      360

gtcaccgtct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

caggtcgtgc ggactcagcc gtcctccgtg tctgggtccc tgggccagag ggtctccatc      480

acctgctctg gaagcagcag caatgttgga tatggtaatt atgtgggctg gttccaacag      540

gtgccagggt cagcccccaa actcctcatc tatgctgcaa ccagtcgagc ctcgggggtc      600

cccgaccgat tctccggctc caggtctggg aatacagcca ccctgaccat cgactcgctc      660

caggctgagg acgaggccga ttattactgt tcatcttatc aacgcggtaa cactggtgtt      720

ttcggcagcg ggaccaggct gaccgtcctg ggt                                   753


<210>  400
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  CB2 nucleotide sequence

<400>  400
caggttcagc ttcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaagc actaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctttaat      180

ccagtcctta agtcccggct cagcatcacc agggacacct ccaagagtca agtctctttg      240

tcattgagca acgtgacaag tgaagacacg gccgtgtact actgtggaag aagttatagg      300

actgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcactatct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

cagtctgtgc tgactcagcc gtcctccgtg tccgggtccc cgggccagac agtctccatc      480

acctgctctg gaagctatat cggtagtagt ggtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccatcat cgtggcgagt gacggtcgac cctcaggggt ccccgaccga      600

ttctctatgt ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc aatatactgg acttttcggc      720

agcgggacca ggctgaccgt cctgggt                                          747


<210>  401
<211>  732
<212>  DNA
<213>  artificial sequence

<220>
<223>  CB3 nucleotide sequence

<400>  401
caggttcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaagc agcgtcgctg taaactgggt ccgccaggct      120

ccaggaaagg tgccggagtg gcttggtggc attattagta atggaggcac aggctataat      180

ccggccctga aatctcggct gagcatcacc agggacacct ccaagagcca agtctccctg      240

gcactgaccc acgtgacaac tgaggacacg gccgtgtact actgtggaag gggagttgaa      300

tgggagggct ctatggacta cttgggccca ggactcctgg tcaccgtctc ctcagaaggt      360

aaatcttctg gctctggctc tgagactaaa gtggatgacc agtctgtgct gactcagccg      420

tcctccgtgt ccgggttcct gggccagagg gtcaccatca cctgctctgg aagcagcagc      480

aacgttggag ctggtagtta tgtgggctgg taccagcagg tcccaggatc gggcctcaga      540

atcctcatct atggtgcaac caagcgagcc tcgggactcc ccgaccgatt ctccggctcc      600

aggtctggga acacagccac cctgaccatc agctcgctcc aggctgagga cgaggccgat      660

tattactgcg tatcttatca gactgatttt actttagttt tcggcagcgg gaccaggctg      720

accgtcctag gt                                                          732


<210>  402
<211>  735
<212>  DNA
<213>  artificial sequence

<220>
<223>  CB7 nucleotide sequence

<400>  402
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc aactatcgtg taggttgggt ccgccaggct      120

ccaggaaagg cactggagtg ggttagtaac atacggagtg gtggaactac atggtataac      180

ccggccctga aatcccggct cagcatcacc gcggacacct ccaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggacacg gccgtatatt attgtgcaag agattcctct      300

ggtgatcttt atgcgtatga ttactggggc ccaggactcc tggtcaccgt ctcctcagaa      360

ggtaaatctt ctggcgcgtc tggcgagtct aaagtggatg accaggccgt gctgactcag      420

ccgtcctccg tgtccaggtc cctgggccag agtgtctcca tgacctgctc tggaagcagc      480

agcaacgttg gatatggtaa ttatatggcc tggttccaac aggttccagg atcagccccc      540

aaactcctca tctatggtgc aaccagtcga gcctcggggg tccccgaccg attctccggc      600

tccaggtctg gcaacacagc gactctgacc atcagctcgc tccaggctga ggacgaggcc      660

gattactact gtgcatctta tgacagcact agcgggggtg tcttcggcag cgggaccagg      720

ctgaccgtcc tgggt                                                       735


<210>  403
<211>  732
<212>  DNA
<213>  artificial sequence

<220>
<223>  CC7 nucleotide sequence

<400>  403
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcactaacc agcaatgctg tgatctgggt ccggcaggct      120

ccaggaaagg cgccggagtg ggttgctttg atagatgttg atggagatgc agcctatgac      180

ccagccctta agtcccgcct cagcatcacc agggacacct ccaagagtca agtctccctt      240

tcactgcgca gcgtgacaac tgaggacacg gccgtgtact actgtgcaag agactatggt      300

agttggggtt atgtttccga catcgactac tggggcccag gactcctggt caccgtctcc      360

tcagaaggta aatcttctgg cgcgtctggc gagtctaaag tggatgacag ggtcgtgcgg      420

actcaaccgt cctccgtgtc tgggtccctg ggccagaggg tctccatcac ctgctctgga      480

agctacatca ctggtagttc tgtaggctgg ttccaacagg tcccaggatc gggcctcaaa      540

accgtcatct atgacaataa cgatcgaccc tcaggggtcc ccgaccgatt ctctggctcc      600

aagtcgggcg acacagccac cctgaccatc agctcgctcc aggctgagga cgaggccgat      660

tattactgtg catcttatga caccagtaac attggtcttt tcggcagcgg gaccaggctg      720

accgtcctgg gt                                                          732


<210>  404
<211>  741
<212>  DNA
<213>  artificial sequence

<220>
<223>  3aA6 nucleotide sequence

<400>  404
caggtgcggc tgcaggagtc gggatccagt ctggtgaagc cctcacagac cctctccctc       60

gtctgcacgg tctctggatt cccattaacc agcaatgctg taggctgggt ccgccaggct      120

ccaggaaagg cgccggagtg gctaggtctc atagatattg atggagacac agcctataac      180

ccagcccttg agtcccggct cagcatcacc agggacacct ccaagagtca agtctccctg      240

tcactgagca gcgtggcaat tgaggacacg gccgtgtact attgtgctcg tcattatgat      300

aaatggggtt atgctgattc gatcgactac tggggcccag gactcctggt caccgtctcc      360

tcagaaggta aatcttctgg cgcgtctggc gagtctaaag tggatgacca ggccctgctg      420

actcagccgt cctccgtgtt tggttccctg ggccagaggg tctccatcac ctgctctgga      480

agcagcagca acgttggata tggtgattat gtaggctggt accaacaggt cccaggatca      540

gcccccaaac tcctcatcta tgatgcaacc actcgagcct cgggggtccc cgaccgattc      600

tccggctcca ggtctgggaa cacagccacc ctgaccatca gctcgctcca ggctgaggac      660

gaggccgatt attactgtgc atcttatcag aatgaaagaa gtggtgtttt cggcagcggg      720

accaggctga ccgtcctggg t                                                741


<210>  405
<211>  732
<212>  DNA
<213>  artificial sequence

<220>
<223>  3aD6 nucleotide sequence

<400>  405
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcactaacc agcaatgctg tgatctgggt ccggcaggct      120

ccaggaaagg cgccggagtg ggttgctttg atagatgttg atggagatgc agcctatgac      180

ccagccctta agtcccgcct cagcatcacc agggacacct ccaagagtca agtctccctt      240

tcactgcgca gcgtgacaac tgaggacacg gccgtgtact actgtgcaag agactatggt      300

agttggggtt atgtttccga catcgactac tggggcccag gactcctggt caccgtctcc      360

tcagaaggta aatcttctgg cgcgtctggc gagtctaaag tggatgacca ggctgtgctg      420

actcagccgt cctccgtgtc tgggtccctg ggccagaggg tctccatcac ctgctctgga      480

agcgacatcg gtggtgctga tgtaggctgg ttccaacagg tcccaggatc gggcctcaga      540

accctcatct atgataatga caatcgaccc tcaggggtcc ccgaccgatt ctctggctcc      600

aagtcgggca acacagccac cctgaccatc agctcgctcc agcctgagga tgaggccgat      660

tatttctgtg gcacttattc tggtgctaac tatggtattt ttggcagcgg gaccaggctg      720

accgtcctgg gt                                                          732


<210>  406
<211>  744
<212>  DNA
<213>  artificial sequence

<220>
<223>  3aB7 nucleotide sequence

<400>  406
caggttcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaact agcaatggtg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtg ggttggtgat aaaagcagtg ctggaaagac atacggtaac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggacacg gccgtgtact actgtgtaag atgcagggat      300

ggtggtgtga cttatggtta tgacgtcgac tactggggcc caggactcct ggtcaccgtc      360

tcctcagaag gtaaatcttc tggcgcgtct ggcgagtcta aagtggatga ccaggctgtg      420

ctgactcagc cgtcctccgt gtccaagtcc ctgggccaga gtgtctccat cacctgctct      480

ggaagcagca gcaacgttgg atatggtgat gttgtgagct ggttccaaca gttcccagga      540

tcagccccca aactcctcat tttcggtaca acgactcgag cctcgggggt ccccgaccga      600

ttctccggct ccaggtctgg caacgcagcg actctaacca tcaactctct ccaggctgag      660

gacgaggccg actattactg tgcgtctttt gatagtgata gcggtggaat tgccggcagc      720

gggaccaggc tgaccgtcct gggt                                             744


<210>  407
<211>  744
<212>  DNA
<213>  artificial sequence

<220>
<223>  3bF4 nucleotide sequence

<400>  407
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctccttgagt agcaatggtg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtg gcttggtgat ataagcagtg ttggaaaaaa atacgctaac      180

ccggccctga aatctcggct cagcttcact agggacacct ccaagagcca agtgtccctg      240

tcactgagca gcgtgacaac tgaggacacg gccgtgtact attgtgtaaa atgcagggat      300

ggtggtgtga cttatggtta tgatatcgac tactggggcc caggactcct ggtcaccgtc      360

tcctcagaag gtaaatcttc tggcgcgtct ggcgagtcta aagtggatga ccaggctgtg      420

ctgactcagc cgtcctccgt gtctaagtcc acgggccaga ctgtctccat cacctgctct      480

ggaagcagca gcaacgttgg gttacgtaat tatgtgacct ggttccaaca ggtcccagga      540

tcagccccca aactcctcat ctatggtgca accagtcgag cctcggggat ccccgaccga      600

ttctccggct ccaggtctgg caacacagcg actctgatca tcagctcgct ccaggctgag      660

gacgaggccg attattactg tgcatctgct gacaccaatg acggtggtgt tttcggcagc      720

gggaccaggc tgaccgtcct gggt                                             744


<210>  408
<211>  744
<212>  DNA
<213>  artificial sequence

<220>
<223>  3aD3 nucleotide sequence

<400>  408
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaact agcaatggtg taggctgggt ccgccgggct      120

ccaggaaagg tgccggagtg ggttggtgat ataagcagtg gtggaaaagt atacgggcac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagcca agtctccctg      240

tcagtgagca gcgtgacaag tgaggacacg gccgtgtact actgtgtaag atgcagggat      300

ggtggtgtga gttatggtta tgatagcgac tactggggcc caggactcct ggtcaccgtc      360

tcctcagaag gtaaatcttc tggcgcgtct ggcgagtcta aagtggatga ccaggctgtg      420

gtgactcagc cgtcctccgt gtccaagtcc ctgggccaga gtgtctccat cacctgctct      480

ggaagcagca gcaacgttgg atatggtgat tatgtgggct ggttccaaca ggtcccagga      540

tcagccccca aactcctcat ctatggtgta accgagcgag cctcgggggt ccccgaccga      600

ttctccggct ccaggtctgg caacacagcg actctgacca tcagctcgat ccaggctgag      660

gacgaggccg attattactg tgcatcttat gacgacagta gcggtggtat tttcggcagc      720

gggaccaggc tgaccgtcct gggt                                             744


<210>  409
<211>  744
<212>  DNA
<213>  artificial sequence

<220>
<223>  3aH6 nucleotide sequence

<400>  409
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctccttgagt agcaatggtg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtg gcttggtgat ataagcagtg ttggaaaaaa atacgctaac      180

ccggccctga aatctcggct cagcttcact agggacacct ccaagagcca agtgtccctg      240

tcactgagca gcgtgacaac tgaggacacg gccgtgtact attgtgtaaa atgcagggat      300

ggtggtgtga cttatggtta tgatatcgac tactggggcc caggactact ggtcaccgcc      360

tcctcagaag gtaaatcttc tggcgcgtct ggcgagtcta aagtggatga ccaggccgtg      420

gtgactcagc cgtcctccgt gtctgggtcc ctgggccaga gtgtctccat cacctgctcc      480

ggaagctccg gcaacgttgg ctatggcgat tatgtgagtt ggttccaaca attccacgga      540

tcggccccca aactcctcat ctatggtgca accaatcttg cctcgggagt tcccgcccga      600

ttctccggct ccaggtctgg caacacggcc acccttacta tcagctcgct ccacgctgag      660

gacgaggccg attactattg tgcatcttat gacagcagta gcggcggtgt gttcggcagc      720

gggaccaggc tgaccgtcct gggt                                             744


<210>  410
<211>  744
<212>  DNA
<213>  artificial sequence

<220>
<223>  3aG3 nucleotide sequence

<400>  410
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaagt agtaatggtg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtg ggttggtgat ataagtagta gtggaaaagc atacgctaat      180

ccggccctga aatcccggct cagcatcacc agggacaccg ccaagaccca agtcttcctg      240

tcactgagca gcgtgacaac tgaggacacg gccgtgtact actgtgtaag atgcagggat      300

ggtggtgtaa gttatggtta tgatatcgac tactggggcc caggactcct ggtcaccgtc      360

tcctcagaag gtaaatcttc tggcgcgtct ggcgagtcta aagtggatga ccaggctgtg      420

ctgactcagc caccctccgt gtccgggtcc ccgggccaga gggtatccat tacctgctct      480

ggaagcagca gcaacatcgg gggtggtaat tatctgagct ggttccaaca ggtcccagga      540

tcagccccca aactcctcat ctatggtgca accagtcgag cctcgggggt ccccgaccga      600

ttctccggct ccagatctgg caacacagcg actctgacaa tcagctcgct ccaggctgag      660

gacgaggccg attattactg tgcatctttt gacaccagta gcggtggtat tttcggcgcc      720

gggaccaggc tgaccgtcct gggt                                             744


<210>  411
<211>  744
<212>  DNA
<213>  artificial sequence

<220>
<223>  3bG4 nucleotide sequence

<400>  411
caggtgcagc ttcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacaa tctctggatt ctcattaatc agcaatggtg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtg ggttggtgat attgctagta gtggaaaggc atacagtaac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagcca agtctccctg      240

tcactgagga gcgtgacaac tgaggacacg gccgtgtact actgtgtaag atgcagggat      300

ggtggtgtga cttatggtta tgatatcgac tactggggcc caggactcct ggtcaccgtc      360

tcctcagaag gtaaatcttc tggcgcgtct ggcgagtcta aagtggatga ccaggctgtg      420

ctgactcagc cgtcatccgt gtccaagtcc ctgggccaga gtgtctccat cacctgctcc      480

ggaagcacta gcaacgttgg aagtggtaat gatgtgagct ggttccaaca ggtcccagga      540

tcagccccca aactcctctt ctacggtgca accaaccgag cctcgggggt ccccgaccga      600

ttctccggct ccaggtctgg caacacagcg actctgacca tcacctcgct tcaggctgag      660

gacgaggccg attattactg tggatcttat gacagcaata gcggtggtat tttcggcagt      720

gggaccaggc tgaccgtcct gggt                                             744


<210>  412
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1B1 amino acid sequence

<400>  412

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Ser Tyr Arg Thr Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Val Ile Val Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Asn Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 


<210>  413
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D9 amino acid sequence

<400>  413

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Ser Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Arg Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Thr Tyr Arg Thr Asp Gly Tyr Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Arg Val Met Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Thr Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Val Ile Phe Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Asn Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Ser 
                245                 


<210>  414
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1F4 amino acid sequence

<400>  414

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Ser Tyr Arg Ala Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Leu Thr Ile Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Val 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Val Ile Val Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Asn Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 


<210>  415
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G10 amino acid sequence

<400>  415

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Ser Tyr Arg Ala Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys 
        115                 120                 125             


Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Met Ser Gly Ser Leu Gly Gln Arg Val Ser Ile 
145                 150                 155                 160 


Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val Ala Ser Asp Gly 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Met Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 


<210>  416
<211>  250
<212>  PRT
<213>  artificial sequence

<220>
<223>  S2C6 amino acid sequence

<400>  416

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Gln Tyr Ala Ala Ser Asp Pro Asp Thr Ser Lys Ser Gln Val Ser 
65                  70                  75                  80  


Leu Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Thr Tyr Arg Thr Asp Gly Phe Ala Tyr Gly Tyr Val Gln Ala 
            100                 105                 110         


Ile Asp Tyr Trp Gly Pro Gly Leu Leu Leu Thr Ile Ser Ser Glu Gly 
        115                 120                 125             


Lys Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val 
    130                 135                 140                 


Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser 
145                 150                 155                 160 


Ile Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val Gly Trp Phe 
                165                 170                 175     


Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val Ala Ser Asp 
            180                 185                 190         


Gly Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Met Ser Lys Ser Gly 
        195                 200                 205             


Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Phe Cys Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Val Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
                245                 250 


<210>  417
<211>  242
<212>  PRT
<213>  artificial sequence

<220>
<223>  412B9 amino acid sequence

<400>  417

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Val Ile Ser Asp 
            20                  25                  30          


Ser Val Ala Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Ala Ser Gly Ser Ser Gly Asn Lys Tyr Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ile Ile Ala Gly Val Asp Val Trp Gly Arg Gly Leu Leu Val 
            100                 105                 110         


Ser Val Ser Ser Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser Lys 
        115                 120                 125             


Val Asp Asp Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala 
    130                 135                 140                 


Leu Gly Gln Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val 
145                 150                 155                 160 


Gly Tyr Gly Asp Tyr Val Gly Trp Tyr Gln Gln Val Pro Gly Ser Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Gly Ala Ala Ser Arg Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr 
    210                 215                 220                 


Asp Ser Ser Asp Gly Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val 
225                 230                 235                 240 


Leu Gly 
        


<210>  418
<211>  247
<212>  PRT
<213>  artificial sequence

<220>
<223>  3aA6 amino acid sequence

<400>  418

Gln Val Arg Leu Gln Glu Ser Gly Ser Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Thr Val Ser Gly Phe Pro Leu Thr Ser Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Leu 
        35                  40                  45              


Gly Leu Ile Asp Ile Asp Gly Asp Thr Ala Tyr Asn Pro Ala Leu Glu 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Ala Ile Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Asp Lys Trp Gly Tyr Ala Asp Ser Ile Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ala 
        115                 120                 125             


Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Leu Leu Thr Gln Pro Ser 
    130                 135                 140                 


Ser Val Phe Gly Ser Leu Gly Gln Arg Val Ser Ile Thr Cys Ser Gly 
145                 150                 155                 160 


Ser Ser Ser Asn Val Gly Tyr Gly Asp Tyr Val Gly Trp Tyr Gln Gln 
                165                 170                 175     


Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr Asp Ala Thr Thr Arg 
            180                 185                 190         


Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr 
        195                 200                 205             


Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ala Ser Tyr Gln Asn Glu Arg Ser Gly Val Phe Gly Ser Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu Gly 
                245         


<210>  419
<211>  244
<212>  PRT
<213>  artificial sequence

<220>
<223>  3aD6 amino acid sequence

<400>  419

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ala Val Ile Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asp Val Asp Gly Asp Ala Ala Tyr Asp Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Ser Trp Gly Tyr Val Ser Asp Ile Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly Ala 
        115                 120                 125             


Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr Gln Pro Ser 
    130                 135                 140                 


Ser Val Ser Gly Ser Leu Gly Gln Arg Val Ser Ile Thr Cys Ser Gly 
145                 150                 155                 160 


Ser Asp Ile Gly Gly Ala Asp Val Gly Trp Phe Gln Gln Val Pro Gly 
                165                 170                 175     


Ser Gly Leu Arg Thr Leu Ile Tyr Asp Asn Asp Asn Arg Pro Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Asp Tyr Phe Cys Gly 
    210                 215                 220                 


Thr Tyr Ser Gly Ala Asn Tyr Gly Ile Phe Gly Ser Gly Thr Arg Leu 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  420
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  3aB7 amino acid sequence

<400>  420

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Val 
        35                  40                  45              


Gly Asp Lys Ser Ser Ala Gly Lys Thr Tyr Gly Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Val Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly 
        115                 120                 125             


Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr Gln Pro 
    130                 135                 140                 


Ser Ser Val Ser Lys Ser Leu Gly Gln Ser Val Ser Ile Thr Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Val Gly Tyr Gly Asp Val Val Ser Trp Phe Gln 
                165                 170                 175     


Gln Phe Pro Gly Ser Ala Pro Lys Leu Leu Ile Phe Gly Thr Thr Thr 
            180                 185                 190         


Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn 
        195                 200                 205             


Ala Ala Thr Leu Thr Ile Asn Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ser Phe Asp Ser Asp Ser Gly Gly Ile Ala Gly Ser 
225                 230                 235                 240 


Gly Thr Arg Leu Thr Val Leu Gly 
                245             


<210>  421
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bF4 amino acid sequence

<400>  421

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Asp Ile Ser Ser Val Gly Lys Lys Tyr Ala Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Phe Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Ile Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly 
        115                 120                 125             


Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr Gln Pro 
    130                 135                 140                 


Ser Ser Val Ser Lys Ser Thr Gly Gln Thr Val Ser Ile Thr Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Val Gly Leu Arg Asn Tyr Val Thr Trp Phe Gln 
                165                 170                 175     


Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr Gly Ala Thr Ser 
            180                 185                 190         


Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Ile Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ser Ala Asp Thr Asn Asp Gly Gly Val Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Arg Leu Thr Val Leu Gly 
                245             


<210>  422
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  3aD3 amino acid sequence

<400>  422

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Gly Trp Val Arg Arg Ala Pro Gly Lys Val Pro Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Ser Ser Gly Gly Lys Val Tyr Gly His Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Val Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Cys Arg Asp Gly Gly Val Ser Tyr Gly Tyr Asp Ser Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly 
        115                 120                 125             


Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Val Thr Gln Pro 
    130                 135                 140                 


Ser Ser Val Ser Lys Ser Leu Gly Gln Ser Val Ser Ile Thr Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Val Gly Tyr Gly Asp Tyr Val Gly Trp Phe Gln 
                165                 170                 175     


Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr Gly Val Thr Glu 
            180                 185                 190         


Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Ile Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ser Tyr Asp Asp Ser Ser Gly Gly Ile Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Arg Leu Thr Val Leu Gly 
                245             


<210>  423
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  3aH6 amino acid sequence

<400>  423

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Asp Ile Ser Ser Val Gly Lys Lys Tyr Ala Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Phe Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Ile Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Leu Leu Val Thr Ala Ser Ser Glu Gly Lys Ser Ser Gly 
        115                 120                 125             


Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Val Thr Gln Pro 
    130                 135                 140                 


Ser Ser Val Ser Gly Ser Leu Gly Gln Ser Val Ser Ile Thr Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Gly Asn Val Gly Tyr Gly Asp Tyr Val Ser Trp Phe Gln 
                165                 170                 175     


Gln Phe His Gly Ser Ala Pro Lys Leu Leu Ile Tyr Gly Ala Thr Asn 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Arg Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu His Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ser Tyr Asp Ser Ser Ser Gly Gly Val Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Arg Leu Thr Val Leu Gly 
                245             


<210>  424
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  3aG3 amino acid sequence

<400>  424

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Ser Ser Ser Gly Lys Ala Tyr Ala Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ala Lys Thr Gln Val Phe Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Cys Arg Asp Gly Gly Val Ser Tyr Gly Tyr Asp Ile Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly 
        115                 120                 125             


Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Gly Ser Pro Gly Gln Arg Val Ser Ile Thr Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Ile Gly Gly Gly Asn Tyr Leu Ser Trp Phe Gln 
                165                 170                 175     


Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr Gly Ala Thr Ser 
            180                 185                 190         


Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ser Phe Asp Thr Ser Ser Gly Gly Ile Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Arg Leu Thr Val Leu Gly 
                245             


<210>  425
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 amino acid sequence

<400>  425

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ile Ser Gly Phe Ser Leu Ile Ser Asn 
            20                  25                  30          


Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Ala Ser Ser Gly Lys Ala Tyr Ser Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Ile Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Leu Leu Val Thr Val Ser Ser Glu Gly Lys Ser Ser Gly 
        115                 120                 125             


Ala Ser Gly Glu Ser Lys Val Asp Asp Gln Ala Val Leu Thr Gln Pro 
    130                 135                 140                 


Ser Ser Val Ser Lys Ser Leu Gly Gln Ser Val Ser Ile Thr Cys Ser 
145                 150                 155                 160 


Gly Ser Thr Ser Asn Val Gly Ser Gly Asn Asp Val Ser Trp Phe Gln 
                165                 170                 175     


Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Phe Tyr Gly Ala Thr Asn 
            180                 185                 190         


Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Thr Ser Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Gly Ser Tyr Asp Ser Asn Ser Gly Gly Ile Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Arg Leu Thr Val Leu Gly 
                245             


<210>  426
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  297-390 VHCDR1 alternative consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N or H

<400>  426

Xaa Xaa Ser Val Gly 
1               5   


<210>  427
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  297-390 VHCDR2 alternative consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Y or F

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  N or K

<400>  427

Gly Ile Asp Xaa Asp Gly Glu Glu Gly Xaa Asn Pro Xaa Leu Xaa Ser 
1               5                   10                  15      


<210>  428
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  297-390 VHCDR3 alternative consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  A or T or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  L or Y

<400>  428

Xaa Tyr Arg Xaa Asp Gly Xaa Gly Tyr Val Gln Ala Ile Asp Tyr 
1               5                   10                  15  


<210>  429
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  297-390 VLCDR1 alternative consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  F or Y

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  I or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S or G

<400>  429

Ser Gly Ser Xaa Ile Gly Xaa Ser Xaa Val Gly 
1               5                   10      


<210>  430
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  430 hexapeptide

<400>  430

Val Gln Ile Val Tyr Lys 
1               5       


<210>  431
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  NS2A1 nucleotide sequence

<400>  431
caggtgcagt tgcaggagtc gggacccagc ctcgtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaagc actaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctttaat      180

ccagtcctta agtcccggct cagcatcacc agggacacct ccaagagtca agtctctttg      240

tcattgagca acgtgacaag tgaagacacg gccgtgtact actgtggaag aagttatagg      300

actgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcactatct cctcagaagg taaatcttct ggcgcgtctg gcgagtctaa agtggatgac      420

cagtctgtgc tgactcagcc gtcctccgtg tccgggtccc cgggccagac agtctccatc      480

acctgctctg gaagctatat cggtagtagt ggtgtaggct ggttccaaca gctcccagga      540

tcgggcctca gaaccatcat cgtggcgagt gacggtcgac cctcaggggt ccccgacgga      600

ttctctatgt ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      660

gacgaggccg attatttctg tggaagtagt gataggactc aatatactgg acttttcggc      720

agcgggacca ggctgaccgt cctgggt                                          747


<210>  432
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  297-390 VLCDR3 alternative consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  V or L

<400>  432

Gly Ser Ser Asp Arg Thr Gln Tyr Thr Gly Xaa 
1               5                   10      


<210>  433
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 antibody variable light chain

<400>  433

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Gly Gly 
            20                  25                  30          


Asn Ser Val Gly Trp Tyr Gln His Leu Pro Gly Ser Gly Leu Lys Thr 
        35                  40                  45              


Ile Ile Tyr Asp Thr Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Val Thr Gly Asp Ser Thr 
                85                  90                  95      


Thr His Asp Asp Leu Val Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  434
<211>  238
<212>  PRT
<213>  artificial sequence

<220>
<223>  412G11 amino acid sequence

<400>  434

Gln Val Arg Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Val Arg Gln Ala Pro Gly Arg Ala Pro Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Trp Arg Gly Gly Arg Ile Glu Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Arg Ser Gly Gly Asp Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
            100                 105                 110         


Glu Gly Lys Ser Ser Gly Ala Ser Gly Glu Ser Lys Val Asp Asp Gln 
        115                 120                 125             


Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln Arg 
    130                 135                 140                 


Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly Asn 
145                 150                 155                 160 


Tyr Val Gly Trp Tyr Gln Gln Val Pro Gly Ser Ala Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Gly Ala Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Arg Ser Glu Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln 
        195                 200                 205             


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Arg Ser Glu 
    210                 215                 220                 


Ser Val Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
225                 230                 235             


<210>  435
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VHFR1

<400>  435

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn 
            20                  25                  30  


<210>  436
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VHFR2

<400>  436

Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu Val 
1               5                   10                  


<210>  437
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VHFR3

<400>  437

Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu Ser 
1               5                   10                  15      


Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  438
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VHFR4

<400>  438

Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  439
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VLFR1

<400>  439

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys 
            20          


<210>  440
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VLFR2

<400>  440

Trp Tyr Gln His Leu Pro Gly Ser Gly Leu Lys Thr Ile Ile Tyr 
1               5                   10                  15  


<210>  441
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VLFR3

<400>  441

Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Asn Ser Leu Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  442
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VLFR4

<400>  442

Val Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  443
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VH Domain

<400>  443

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Val Gly Cys Ser Ser Asp Gly Thr Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly His Tyr Ser Ile Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  444
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 VL Domain

<400>  444

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Gly Gly 
            20                  25                  30          


Asn Ser Val Gly Trp Tyr Gln His Leu Pro Gly Ser Gly Leu Lys Thr 
        35                  40                  45              


Ile Ile Tyr Asp Thr Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Val Thr Gly Asp Ser Thr 
                85                  90                  95      


Thr His Asp Asp Leu Val Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  445
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 mAB Heavy Chain

<400>  445

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Val Gly Cys Ser Ser Asp Gly Thr Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly His Tyr Ser Ile Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Ala Lys Thr Thr 
        115                 120                 125             


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
    130                 135                 140                 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
            180                 185                 190         


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
    210                 215                 220                 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
        355                 360                 365             


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
    370                 375                 380                 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
385                 390                 395                 400 


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
                405                 410                 415     


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
            420                 425                 430         


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
        435                 440                 445             


Ser Arg Thr Pro Gly Lys 
    450                 


<210>  446
<211>  218
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 mAB Light Chain

<400>  446

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Gly Gly 
            20                  25                  30          


Asn Ser Val Gly Trp Tyr Gln His Leu Pro Gly Ser Gly Leu Lys Thr 
        35                  40                  45              


Ile Ile Tyr Asp Thr Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Val Thr Gly Asp Ser Thr 
                85                  90                  95      


Thr His Asp Asp Leu Val Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro 
145                 150                 155                 160 


Val Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu 
            180                 185                 190         


Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val 
        195                 200                 205             


Glu Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215             


<210>  447
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VHFR1

<400>  447

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  448
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VHFR2

<400>  448

Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val Ala 
1               5                   10                  


<210>  449
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VHFR3

<400>  449

Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu Ser 
1               5                   10                  15      


Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg 
            20                  25                  30          


<210>  450
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VHFR4

<400>  450

Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  451
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VLFR1

<400>  451

Gln Ala Val Val Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys 
            20          


<210>  452
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VLFR2

<400>  452

Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val 
1               5                   10                  15  


<210>  453
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VLFR3

<400>  453

Gly Val Pro Asp Arg Phe Ser Met Ser Lys Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys 
            20                  25                  30          


<210>  454
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VLFR4

<400>  454

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  455
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VH Domain

<400>  455

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Ser Tyr Arg Ala Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  456
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 VL Domain

<400>  456

Gln Ala Val Val Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val 
            20                  25                  30          


Gly Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val 
        35                  40                  45              


Ala Ser Asp Gly Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Met Ser 
    50                  55                  60                  


Lys Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gly Ser Ser Asp Arg Thr Pro Tyr Thr 
                85                  90                  95      


Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 


<210>  457
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 mAB Heavy Chain

<400>  457

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Thr Asp Gly Glu Glu Gly Tyr Asn Pro Ala Leu Asn 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Ser Tyr Arg Ala Asp Gly Leu Ala Tyr Gly Tyr Val Gln Ala Ile 
            100                 105                 110         


Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Ala Lys Thr 
        115                 120                 125             


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr 
    130                 135                 140                 


Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
            180                 185                 190         


Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
    210                 215                 220                 


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
225                 230                 235                 240 


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
                245                 250                 255     


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
        275                 280                 285             


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
    290                 295                 300                 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
305                 310                 315                 320 


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
            340                 345                 350         


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
        355                 360                 365             


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
    370                 375                 380                 


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
385                 390                 395                 400 


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
                405                 410                 415     


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
            420                 425                 430         


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
        435                 440                 445             


Phe Ser Arg Thr Pro Gly Lys 
    450                 455 


<210>  458
<211>  215
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1G2 mAB Light Chain

<400>  458

Gln Ala Val Val Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Phe Ile Gly Ile Ser Ser Val 
            20                  25                  30          


Gly Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Val 
        35                  40                  45              


Ala Ser Asp Gly Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Met Ser 
    50                  55                  60                  


Lys Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gly Ser Ser Asp Arg Thr Pro Tyr Thr 
                85                  90                  95      


Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly Gln Pro 
            100                 105                 110         


Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln 
145                 150                 155                 160 


Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met 
                165                 170                 175     


Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser 
        195                 200                 205             


Leu Ser Arg Ala Asp Cys Ser 
    210                 215 


<210>  459
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VHFR1

<400>  459

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Val Ile 
            20                  25                  30  


<210>  460
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VHFR2

<400>  460

Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu Gly 
1               5                   10                  


<210>  461
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VHFR3

<400>  461

Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu Ser 
1               5                   10                  15      


Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  462
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VHFR4

<400>  462

Trp Gly Arg Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  463
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VLFR1

<400>  463

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys 
            20          


<210>  464
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VLFR2

<400>  464

Trp Tyr Gln Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  465
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VLFR3

<400>  465

Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asp Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Thr Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  466
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VLFR4

<400>  466

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  467
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VH Domain

<400>  467

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Val Ile Ser Asp 
            20                  25                  30          


Ser Val Ala Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Ala Ser Gly Ser Ser Gly Asn Lys Tyr Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ile Ile Ala Gly Val Asp Val Trp Gly Arg Gly Leu Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  468
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 VL Domain

<400>  468

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Gly Trp Tyr Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Thr Ala Ile Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asp Thr Ala Thr Leu Thr Ile Thr Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Gln Ser Asn 
                85                  90                  95      


Tyr Ala Phe Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  469
<211>  446
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 mAB Heavy Chain

<400>  469

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Val Ile Ser Asp 
            20                  25                  30          


Ser Val Ala Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Leu 
        35                  40                  45              


Gly Ala Ser Gly Ser Ser Gly Asn Lys Tyr Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ile Ile Ala Gly Val Asp Val Trp Gly Arg Gly Leu Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
    210                 215                 220                 


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
                245                 250                 255     


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
            260                 265                 270         


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
    290                 295                 300                 


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
                325                 330                 335     


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
            340                 345                 350         


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
        355                 360                 365             


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
    370                 375                 380                 


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
                405                 410                 415     


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445     


<210>  470
<211>  216
<212>  PRT
<213>  artificial sequence

<220>
<223>  412E10 mAB Light Chain

<400>  470

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Gly Trp Tyr Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Thr Ala Ile Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asp Thr Ala Thr Leu Thr Ile Thr Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Gln Ser Asn 
                85                  90                  95      


Tyr Ala Phe Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  471
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VHFR1

<400>  471

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ile Ser Gly Phe Ser Leu Ile 
            20                  25                  30  


<210>  472
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VHFR2

<400>  472

Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Val Gly 
1               5                   10                  


<210>  473
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VHFR3

<400>  473

Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu Ser 
1               5                   10                  15      


Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  474
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VHFR4

<400>  474

Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  475
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VLFR1

<400>  475

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys 
            20          


<210>  476
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VLFR2

<400>  476

Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Phe Tyr 
1               5                   10                  15  


<210>  477
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VLFR3

<400>  477

Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Thr Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  478
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VLFR4

<400>  478

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  479
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VH Domain

<400>  479

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ile Ser Gly Phe Ser Leu Ile Ser Asn 
            20                  25                  30          


Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Ala Ser Ser Gly Lys Ala Tyr Ser Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Ile Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
        115                 120         


<210>  480
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 VL Domain

<400>  480

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Ser Gly Ser Thr Ser Asn Val Gly Ser Gly 
            20                  25                  30          


Asn Asp Val Ser Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Phe Tyr Gly Ala Thr Asn Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Asp Ser Asn 
                85                  90                  95      


Ser Gly Gly Ile Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  481
<211>  452
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 mAB Heavy Chain

<400>  481

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ile Ser Gly Phe Ser Leu Ile Ser Asn 
            20                  25                  30          


Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Ala Ser Ser Gly Lys Ala Tyr Ser Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Cys Arg Asp Gly Gly Val Thr Tyr Gly Tyr Asp Ile Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Leu Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro 
    210                 215                 220                 


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
                245                 250                 255     


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
        275                 280                 285             


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
    290                 295                 300                 


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
305                 310                 315                 320 


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
        355                 360                 365             


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
    370                 375                 380                 


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
                405                 410                 415     


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
            420                 425                 430         


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
        435                 440                 445             


Thr Pro Gly Lys 
    450         


<210>  482
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  3bG4 mAB Light Chain

<400>  482

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Ser Gly Ser Thr Ser Asn Val Gly Ser Gly 
            20                  25                  30          


Asn Asp Val Ser Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Phe Tyr Gly Ala Thr Asn Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Asp Ser Asn 
                85                  90                  95      


Ser Gly Gly Ile Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  483
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VHFR1

<400>  483

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  484
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VHFR2

<400>  484

Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val Gly 
1               5                   10                  


<210>  485
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VHFR3

<400>  485

Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu Ser 
1               5                   10                  15      


Leu Ser Ser Val Thr Thr Glu Asp Met Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  486
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VHFR4

<400>  486

Trp Gly Arg Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  487
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VLFR1

<400>  487

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Ala Cys 
            20          


<210>  488
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VLFR2

<400>  488

Trp Phe Gln Gln Ile Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  489
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VLFR3

<400>  489

Gly Val Pro Asp Arg Phe Ser Gly Ala Arg Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Asn Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  490
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VLFR4

<400>  490

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  491
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VH Domain

<400>  491

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Arg 
            20                  25                  30          


Gly Val Ala Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Gly Thr Met Arg Ser Gly Gly Thr Ile Asp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Met Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Leu Ser Gly Asp Arg Tyr Ala Trp Gly Arg Gly Leu Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  492
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 VL Domain

<400>  492

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Ala Cys Ser Gly Ser Arg Ser Asp Ile Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Phe Gln Gln Ile Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Thr Asn Thr Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ala Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Asn Ile Asp Ser Ser 
                85                  90                  95      


Arg Ser His Leu Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  493
<211>  447
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 mAB Heavy Chain

<400>  493

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Arg 
            20                  25                  30          


Gly Val Ala Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Gly Thr Met Arg Ser Gly Gly Thr Ile Asp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Met Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Leu Ser Gly Asp Arg Tyr Ala Trp Gly Arg Gly Leu Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
    210                 215                 220                 


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
                245                 250                 255     


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
            260                 265                 270         


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
    290                 295                 300                 


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
                325                 330                 335     


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
            340                 345                 350         


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
        355                 360                 365             


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
    370                 375                 380                 


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
                405                 410                 415     


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445         


<210>  494
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2E8 mAB Light Chain

<400>  494

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Ala Cys Ser Gly Ser Arg Ser Asp Ile Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Phe Gln Gln Ile Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Thr Asn Thr Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ala Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Asn Ile Asp Ser Ser 
                85                  90                  95      


Arg Ser His Leu Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  495
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VHFR1

<400>  495

Arg Val Arg Leu Gln Gly Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Phe Asp 
            20                  25                  30  


<210>  496
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VHFR2

<400>  496

Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  497
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VHFR3

<400>  497

Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu Ser 
1               5                   10                  15      


Val Ser Ser Val Thr Ile Glu Asp Thr Ala Leu Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  498
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VHFR4

<400>  498

Trp Ser Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  499
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VLFR1

<400>  499

Gln Val Val Arg Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys 
            20          


<210>  500
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VLFR2

<400>  500

Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  501
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VLFR3

<400>  501

Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Asp Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  502
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VLFR4

<400>  502

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  503
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VH Domain

<400>  503

Arg Val Arg Leu Gln Gly Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Phe Asp Ser Tyr 
            20                  25                  30          


Tyr Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Asn Ile Tyr Ser Thr Gly Arg Ala Phe Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Val Ser Ser Val Thr Ile Glu Asp Thr Ala Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Ser Tyr Tyr His Gly Gly Gly Asn Gly Met Val Asp Phe Phe 
            100                 105                 110         


Asp Tyr Trp Ser Pro Gly Leu Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  504
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 VL Domain

<400>  504

Gln Val Val Arg Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Gly Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asp Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gln Arg Gly 
                85                  90                  95      


Asn Thr Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  505
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 mAB Heavy Chain

<400>  505

Arg Val Arg Leu Gln Gly Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Phe Asp Ser Tyr 
            20                  25                  30          


Tyr Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Asn Ile Tyr Ser Thr Gly Arg Ala Phe Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Val Ser Ser Val Thr Ile Glu Asp Thr Ala Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Ser Tyr Tyr His Gly Gly Gly Asn Gly Met Val Asp Phe Phe 
            100                 105                 110         


Asp Tyr Trp Ser Pro Gly Leu Leu Val Thr Val Ser Ser Ala Lys Thr 
        115                 120                 125             


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr 
    130                 135                 140                 


Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
            180                 185                 190         


Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
    210                 215                 220                 


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
225                 230                 235                 240 


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
                245                 250                 255     


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
        275                 280                 285             


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
    290                 295                 300                 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
305                 310                 315                 320 


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
            340                 345                 350         


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
        355                 360                 365             


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
    370                 375                 380                 


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
385                 390                 395                 400 


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
                405                 410                 415     


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
            420                 425                 430         


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
        435                 440                 445             


Phe Ser Arg Thr Pro Gly Lys 
    450                 455 


<210>  506
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA7 mAB Light Chain

<400>  506

Gln Val Val Arg Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Gly Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asp Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gln Arg Gly 
                85                  90                  95      


Asn Thr Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  507
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VHFR1

<400>  507

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  508
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VHFR2

<400>  508

Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val Ser 
1               5                   10                  


<210>  509
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VHFR3

<400>  509

Arg Leu Ser Ile Thr Ala Asp Thr Ser Lys Ser Gln Val Ser Leu Ser 
1               5                   10                  15      


Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  510
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VHFR4

<400>  510

Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  511
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VLFR1

<400>  511

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Arg Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Met Thr Cys 
            20          


<210>  512
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VLFR2

<400>  512

Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  513
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VLFR3

<400>  513

Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  514
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VLFR4

<400>  514

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  515
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VH Domain

<400>  515

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Arg Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Arg Ser Gly Gly Thr Thr Trp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Ala Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ser Ser Gly Asp Leu Tyr Ala Tyr Asp Tyr Trp Gly Pro Gly 
            100                 105                 110         


Leu Leu Val Thr Val Ser Ser 
        115                 


<210>  516
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 VL Domain

<400>  516

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Arg Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Met Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Met Ala Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Ser Thr 
                85                  90                  95      


Ser Gly Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  517
<211>  449
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 mAB Heavy Chain

<400>  517

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Arg Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Arg Ser Gly Gly Thr Thr Trp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Ala Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ser Ser Gly Asp Leu Tyr Ala Tyr Asp Tyr Trp Gly Pro Gly 
            100                 105                 110         


Leu Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 
    210                 215                 220                 


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
                245                 250                 255     


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
            260                 265                 270         


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
    290                 295                 300                 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
        355                 360                 365             


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
    370                 375                 380                 


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
                405                 410                 415     


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
            420                 425                 430         


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
        435                 440                 445             


Lys 
    


<210>  518
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  CB7 mAB Light Chain

<400>  518

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Arg Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Met Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Met Ala Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Ser Thr 
                85                  90                  95      


Ser Gly Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  519
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VHFR1

<400>  519

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  520
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VHFR2

<400>  520

Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val Ala 
1               5                   10                  


<210>  521
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VHFR3

<400>  521

Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu Ser 
1               5                   10                  15      


Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  522
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VHFR4

<400>  522

Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  523
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VLFR1

<400>  523

Arg Val Val Arg Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys 
            20          


<210>  524
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VLFR2

<400>  524

Trp Phe Gln Gln Val Pro Gly Ser Gly Leu Lys Thr Val Ile Tyr 
1               5                   10                  15  


<210>  525
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VLFR3

<400>  525

Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  526
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VLFR4

<400>  526

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  527
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VH Domain

<400>  527

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ala Val Ile Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asp Val Asp Gly Asp Ala Ala Tyr Asp Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Ser Trp Gly Tyr Val Ser Asp Ile Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Leu Leu Val Thr Val Ser Ser 
        115                 120     


<210>  528
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 VL Domain

<400>  528

Arg Val Val Arg Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Tyr Ile Thr Gly Ser Ser Val 
            20                  25                  30          


Gly Trp Phe Gln Gln Val Pro Gly Ser Gly Leu Lys Thr Val Ile Tyr 
        35                  40                  45              


Asp Asn Asn Asp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Thr Ser Asn Ile Gly 
                85                  90                  95      


Leu Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105             


<210>  529
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 mAB Heavy Chain

<400>  529

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Ala Val Ile Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asp Val Asp Gly Asp Ala Ala Tyr Asp Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Arg Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Ser Trp Gly Tyr Val Ser Asp Ile Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Leu Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
    210                 215                 220                 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
                245                 250                 255     


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
            260                 265                 270         


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
        355                 360                 365             


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
    370                 375                 380                 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
                405                 410                 415     


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
            420                 425                 430         


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  530
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  CC7 mAB Light Chain

<400>  530

Arg Val Val Arg Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Tyr Ile Thr Gly Ser Ser Val 
            20                  25                  30          


Gly Trp Phe Gln Gln Val Pro Gly Ser Gly Leu Lys Thr Val Ile Tyr 
        35                  40                  45              


Asp Asn Asn Asp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Thr Ser Asn Ile Gly 
                85                  90                  95      


Leu Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly Gln Pro Lys 
            100                 105                 110         


Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Glu 
        115                 120                 125             


Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln Gly 
145                 150                 155                 160 


Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met Ala 
                165                 170                 175     


Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser Leu 
        195                 200                 205             


Ser Arg Ala Asp Cys Ser 
    210                 


<210>  531
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VHFR1

<400>  531

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  532
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VHFR2

<400>  532

Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  533
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VHFR3

<400>  533

Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Val Ser Leu Ser 
1               5                   10                  15      


Leu Ser Ser Ala Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg 
            20                  25                  30          


<210>  534
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VHFR4

<400>  534

Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  535
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VLFR1

<400>  535

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys 
            20          


<210>  536
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VLFR2

<400>  536

Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Ile Leu Ile Tyr 
1               5                   10                  15  


<210>  537
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VLFR3

<400>  537

Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Thr Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  538
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VLFR4

<400>  538

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  539
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VH Domain

<400>  539

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Pro Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Glu Asn Asp Gly Ser Ala Asn Tyr Ala Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Ala Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Glu Phe Gly Gly Ser Asp Gly Tyr Thr Tyr Phe Val Asp Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  540
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 VL Domain

<400>  540

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Ile 
        35                  40                  45              


Leu Ile Tyr Gly Ala Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Gly Ser 
                85                  90                  95      


Ser Ser Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  541
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 mAB Heavy Chain

<400>  541

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Pro Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Glu Asn Asp Gly Ser Ala Asn Tyr Ala Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Ala Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Glu Phe Gly Gly Ser Asp Gly Tyr Thr Tyr Phe Val Asp Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Ala Lys Thr Thr 
        115                 120                 125             


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
    130                 135                 140                 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
            180                 185                 190         


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
    210                 215                 220                 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
        355                 360                 365             


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
    370                 375                 380                 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
385                 390                 395                 400 


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
                405                 410                 415     


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
            420                 425                 430         


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
        435                 440                 445             


Ser Arg Thr Pro Gly Lys 
    450                 


<210>  542
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE2 mAB Light Chain

<400>  542

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Lys Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Ile 
        35                  40                  45              


Leu Ile Tyr Gly Ala Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Gly Ser 
                85                  90                  95      


Ser Ser Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  543
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VHFR1

<400>  543

Gln Val Arg Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Phe Ser Leu Ile 
            20                  25                  30  


<210>  544
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VHFR2

<400>  544

Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu Ala 
1               5                   10                  


<210>  545
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VHFR3

<400>  545

Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu Ser 
1               5                   10                  15      


Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  546
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VHFR4

<400>  546

Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  547
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VLFR1

<400>  547

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys 
            20          


<210>  548
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VLFR2

<400>  548

Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile Ile Tyr 
1               5                   10                  15  


<210>  549
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VLFR3

<400>  549

Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Val Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Asp Ser Leu Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys 
            20                  25                  30          


<210>  550
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VLFR4

<400>  550

Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
1               5                   10      


<210>  551
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VH Domain

<400>  551

Gln Val Arg Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Ala Gly Cys Ser Ser Asp Gly Lys Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Tyr Tyr Pro Val Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  552
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 VL Domain

<400>  552

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Arg Asn 
            20                  25                  30          


Asp Val Ala Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile 
        35                  40                  45              


Ile Tyr Gly Thr Thr Ser Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Val Thr Ala Thr Leu Thr Ile Asp Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ser Gly Asp Ser Ser Ala 
                85                  90                  95      


Ile Asn Asp Ile Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  553
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 mAB Heavy Chain

<400>  553

Gln Val Arg Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Ala Gly Cys Ser Ser Asp Gly Lys Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Tyr Tyr Pro Val Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Ala Lys Thr Thr 
        115                 120                 125             


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
    130                 135                 140                 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
            180                 185                 190         


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
    210                 215                 220                 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
        355                 360                 365             


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
    370                 375                 380                 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
385                 390                 395                 400 


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
                405                 410                 415     


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
            420                 425                 430         


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
        435                 440                 445             


Ser Arg Thr Pro Gly Lys 
    450                 


<210>  554
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  CE3 mAB Light Chain

<400>  554

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Arg Asn 
            20                  25                  30          


Asp Val Ala Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile 
        35                  40                  45              


Ile Tyr Gly Thr Thr Ser Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Val Thr Ala Thr Leu Thr Ile Asp Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ser Gly Asp Ser Ser Ala 
                85                  90                  95      


Ile Asn Asp Ile Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  555
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VHFR1

<400>  555

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  556
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VHFR2

<400>  556

Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Ile Ser 
1               5                   10                  


<210>  557
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VHFR3

<400>  557

Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Phe Ser Leu Ser 
1               5                   10                  15      


Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  558
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VHFR4

<400>  558

Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  559
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VLFR1

<400>  559

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Thr 
1               5                   10                  15      


Glu Arg Val Ser Ile Thr Cys 
            20              


<210>  560
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VLFR2

<400>  560

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  561
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VLFR3

<400>  561

Asp Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Thr Ser Leu Glu Ala Asp Asp Thr Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  562
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VLFR4

<400>  562

Phe Gly Gly Gly Thr Asn Val Glu Ile Lys 
1               5                   10  


<210>  563
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VH Domain

<400>  563

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val Tyr Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Ile 
        35                  40                  45              


Ser Ile Met Tyr Ala Ser Gly Arg Val Asp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Ile Glu Asn Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  564
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 VL Domain

<400>  564

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Thr 
1               5                   10                  15      


Glu Arg Val Ser Ile Thr Cys Arg Thr Ser Gln Ser Val Asn Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Arg Leu Tyr Thr Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Thr Ser Leu Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Asn Val Glu Ile Lys 
            100                 105         


<210>  565
<211>  442
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 mAB Heavy Chain

<400>  565

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val Tyr Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Ile 
        35                  40                  45              


Ser Ile Met Tyr Ala Ser Gly Arg Val Asp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Ile Glu Asn Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
        115                 120                 125             


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
                165                 170                 175     


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
            180                 185                 190         


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
    210                 215                 220                 


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
            260                 265                 270         


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
        275                 280                 285             


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
    290                 295                 300                 


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
305                 310                 315                 320 


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
                325                 330                 335     


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
            340                 345                 350         


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
        355                 360                 365             


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
                405                 410                 415     


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440         


<210>  566
<211>  213
<212>  PRT
<213>  artificial sequence

<220>
<223>  CA4 mAB Light Chain

<400>  566

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Thr 
1               5                   10                  15      


Glu Arg Val Ser Ile Thr Cys Arg Thr Ser Gln Ser Val Asn Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Arg Leu Tyr Thr Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Thr Ser Leu Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ser Thr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Asn Val Glu Ile Lys Gly Gln Pro Lys Ser 
            100                 105                 110         


Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Glu Thr 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro Gly Val 
    130                 135                 140                 


Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln Gly Met 
145                 150                 155                 160 


Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met Ala Ser 
                165                 170                 175     


Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser Leu Ser 
        195                 200                 205             


Arg Ala Asp Cys Ser 
    210             


<210>  567
<211>  372
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1D12 VH Nucleotide Sequence

<400>  567
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattgaac aacaatgctg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtc gcttgtgggt tgtagcagtg atggaacgtg ttactataat      180

tcggccctga aatcccggct cgacatcacc agggacacct ccaagaacca gatctccctg      240

tcactgagca gcgttacaac tgacgacgcg gccgtgtact attgtacaag aggccattat      300

agtatttatg gttatgacta tcttggcact atcgactact ggggcccagg actcctggtc      360

accgtctcct ca                                                          372


<210>  568
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1D12 VL Nucleotide Sequence

<400>  568
caggctgtgc tgactcagcc gtcctccgtg tccgggtccc tgggccagag ggtctccatc       60

acctgctctg gaagcagcag caacgtcggg ggtggtaata gtgtgggctg gtaccaacac      120

ctcccaggct caggcctcaa aaccatcatc tatgatacta acagtcgacc ctcgggggtc      180

ccggaccgat tctctggctc caggtctggc aacacggcca ccctaaccat caactcgctc      240

caggctgagg acgagggtga ttattactgt gtaacgggtg acagcactac tcatgatgat      300

cttgtcggca gcgggaccag gctgaccgtc ctgggg                                336


<210>  569
<211>  375
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1G2 VH Nucleotide Sequence

<400>  569
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc agcaattctg tgggctgggt ccgacaggct      120

ccaggaaagg cgccggagtg ggttgctggt atagatactg atggagaaga aggctataat      180

ccagccctta actcccggct cagcatcacc agggacacct ccaagagtca agtctctttg      240

tcattgagca gcgtgacaag tgaggacacg gccgtgtact actgtggaag aagttatagg      300

gctgatggtc ttgcttacgg ttatgtccaa gccatcgact actggggccc aggactcctg      360

gtcaccgtct cctca                                                       375


<210>  570
<211>  327
<212>  DNA
<213>  artificial sequence

<220>
<223>  S1G2 VL Nucleotide Sequence

<400>  570
caggccgtgg tgactcagcc gtcctccgtg tctgggtccc tgggccagag ggtctccatc       60

acctgctctg gaagcttcat cggtattagt agtgtaggct ggttccaaca gctcccagga      120

tcgggcctca gaaccatcat cgtggcgagt gacggtcgac cctcaggggt ccccgaccga      180

ttctctatgt ccaaatcggg caacacagcc accctgacca tcagctcgct ccaggctgag      240

gacgaggccg attatttctg tggaagtagt gataggactc cttatactgg ggtcttcggc      300

agcgggacca ggctgaccgt cctgggt                                          327


<210>  571
<211>  357
<212>  DNA
<213>  artificial sequence

<220>
<223>  CB7 VH Nucleotide Sequence

<400>  571
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc aactatcgtg taggttgggt ccgccaggct      120

ccaggaaagg cactggagtg ggttagtaac atacggagtg gtggaactac atggtataac      180

ccggccctga aatcccggct cagcatcacc gcggacacct ccaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggacacg gccgtatatt attgtgcaag agattcctct      300

ggtgatcttt atgcgtatga ttactggggc ccaggactcc tggtcaccgt ctcctca         357


<210>  572
<211>  333
<212>  DNA
<213>  artificial sequence

<220>
<223>  CB7 VL Nucleotide Sequence

<400>  572
caggccgtgc tgactcagcc gtcctccgtg tccaggtccc tgggccagag tgtctccatg       60

acctgctctg gaagcagcag caacgttgga tatggtaatt atatggcctg gttccaacag      120

gttccaggat cagcccccaa actcctcatc tatggtgcaa ccagtcgagc ctcgggggtc      180

cccgaccgat tctccggctc caggtctggc aacacagcga ctctgaccat cagctcgctc      240

caggctgagg acgaggccga ttactactgt gcatcttatg acagcactag cgggggtgtc      300

ttcggcagcg ggaccaggct gaccgtcctg ggt                                   333


<210>  573
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  CC7 VH Nucleotide Sequence

<400>  573
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcactaacc agcaatgctg tgatctgggt ccggcaggct      120

ccaggaaagg cgccggagtg ggttgctttg atagatgttg atggagatgc agcctatgac      180

ccagccctta agtcccgcct cagcatcacc agggacacct ccaagagtca agtctccctt      240

tcactgcgca gcgtgacaac tgaggacacg gccgtgtact actgtgcaag agactatggt      300

agttggggtt atgtttccga catcgactac tggggcccag gactcctggt caccgtctcc      360

tca                                                                    363


<210>  574
<211>  324
<212>  DNA
<213>  artificial sequence

<220>
<223>  CC7 VL Nucleotide Sequence

<400>  574
agggtcgtgc ggactcaacc gtcctccgtg tctgggtccc tgggccagag ggtctccatc       60

acctgctctg gaagctacat cactggtagt tctgtaggct ggttccaaca ggtcccagga      120

tcgggcctca aaaccgtcat ctatgacaat aacgatcgac cctcaggggt ccccgaccga      180

ttctctggct ccaagtcggg cgacacagcc accctgacca tcagctcgct ccaggctgag      240

gacgaggccg attattactg tgcatcttat gacaccagta acattggtct tttcggcagc      300

gggaccaggc tgaccgtcct gggt                                             324


<210>  575
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  CA4 VH Nucleotide Sequence

<400>  575
caggttcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc agctattccg tatactgggt ccgccaggct      120

ccaggccagg cactggagtg gattagtatt atgtatgcta gtggaagagt agactataac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagtca attctccctg      240

tcattgagca gcgtgacaac tgaggacacg gccgtctact actgtacaag aggaatcgaa      300

aactggggcc ccggactcct ggtcaccgtc tcctca                                336


<210>  576
<211>  324
<212>  DNA
<213>  artificial sequence

<220>
<223>  CA4 VL Nucleotide Sequence

<400>  576
gacatccagg tgacccagtc tccgtcctcc ctgtctgcat ctctaacaga gagagtctcc       60

atcacttgcc ggaccagtca gagcgttaac aattacttaa gctggtatca gcagaaacca      120

gggcaagctc ctaagctcct gatctattat gcaaccagat tgtacaccga tgtcccatcc      180

cggttcagtg gcagtggatc tgggacagat tacaccctca ccatcaccag cctggaggcg      240

gacgacactg caacttatta ctgtctacaa tatgatagta cacctcttgc attcggcggt      300

gggaccaacg tggaaatcaa acgg                                             324


<210>  577
<211>  366
<212>  DNA
<213>  artificial sequence

<220>
<223>  3bG4 VH Nucleotide Sequence

<400>  577
caggtgcagc ttcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacaa tctctggatt ctcattaatc agcaatggtg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtg ggttggtgat attgctagta gtggaaaggc atacagtaac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagcca agtctccctg      240

tcactgagga gcgtgacaac tgaggacacg gccgtgtact actgtgtaag atgcagggat      300

ggtggtgtga cttatggtta tgatatcgac tactggggcc caggactcct ggtcaccgtc      360

tcctca                                                                 366


<210>  578
<211>  333
<212>  DNA
<213>  artificial sequence

<220>
<223>  3bG4 VL Nucleotide Sequence

<400>  578
caggctgtgc tgactcagcc gtcatccgtg tccaagtccc tgggccagag tgtctccatc       60

acctgctccg gaagcactag caacgttgga agtggtaatg atgtgagctg gttccaacag      120

gtcccaggat cagcccccaa actcctcttc tacggtgcaa ccaaccgagc ctcgggggtc      180

cccgaccgat tctccggctc caggtctggc aacacagcga ctctgaccat cacctcgctt      240

caggctgagg acgaggccga ttattactgt ggatcttatg acagcaatag cggtggtatt      300

ttcggcagtg ggaccaggct gaccgtcctg ggt                                   333


<210>  579
<211>  375
<212>  DNA
<213>  artificial sequence

<220>
<223>  CA7 VH Nucleotide Sequence

<400>  579
cgggtgcggc tgcaggggtc gggacccagc ctggtgaaac cttcacagac cctctccctc       60

acctgcacgg tctctggatt ctcttttgac agctattatg taggctgggt ccgccaggct      120

ccaggaaagg cactggagtg gcttggtaat atatatagta ctggaagggc attctataac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagcca agtctcccta      240

tcagtgagca gcgtgacaat tgaggacacg gccctgtact actgtgtcag aggctcgtat      300

tatcacggtg gtggcaatgg gatggtcgac tttttcgact actggagccc aggactcctg      360

gtcaccgtct cctca                                                       375


<210>  580
<211>  333
<212>  DNA
<213>  artificial sequence

<220>
<223>  CA7 VL Nucleotide Sequence

<400>  580
caggtcgtgc ggactcagcc gtcctccgtg tctgggtccc tgggccagag ggtctccatc       60

acctgctctg gaagcagcag caatgttgga tatggtaatt atgtgggctg gttccaacag      120

gtgccagggt cagcccccaa actcctcatc tatgctgcaa ccagtcgagc ctcgggggtc      180

cccgaccgat tctccggctc caggtctggg aatacagcca ccctgaccat cgactcgctc      240

caggctgagg acgaggccga ttattactgt tcatcttatc aacgcggtaa cactggtgtt      300

ttcggcagcg ggaccaggct gaccgtcctg ggt                                   333


<210>  581
<211>  351
<212>  DNA
<213>  artificial sequence

<220>
<223>  E2E8 VH Nucleotide Sequence

<400>  581
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc gaccgtggtg tagcctgggt ccgccaggct      120

ccaggaaagg cactggagtg ggttggtact atgcgtagtg gtggaacgat agactataac      180

ccggccctga aatcccggct cagcatcacc agggacacct ccaagagcca agttttcctg      240

tcactgagca gcgtcacaac tgaggacatg gccatgtact actgtgccag aggttatttg      300

agcggtgatc gttatgcctg gggccgagga ctcctggtca ccgtctcctc a               351


<210>  582
<211>  333
<212>  DNA
<213>  artificial sequence

<220>
<223>  E2E8 VL Nucleotide Sequence

<400>  582
caggctgtgc tgactcagcc gtcctccgtg tccaagtccc tgggccagag tgtctccatc       60

gcctgctctg gaagcaggag cgacattgga tatggtaatt atgtgagctg gttccaacag      120

atcccaggat cagcccccaa actccttatt tatgatacaa acactcgggc ctcgggggtc      180

cccgaccgat tctccggcgc caggtctggc aacacagcaa cactgaccat caactcgctc      240

caggctgagg acgaggccga ttattactgt gcaaatattg acagtagtcg cagtcatctt      300

ttcggcagtg gcaccagact gaccgtcctg ggt                                   333


<210>  583
<211>  348
<212>  DNA
<213>  artificial sequence

<220>
<223>  412E10 VH Nucleotide Sequence

<400>  583
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggctt ctctgtaata agcgattctg tagcctgggt ccgccaggct      120

ccaggaaaag tgccggagtg gcttggtgct agcggcagtt ctggaaacaa atactataac      180

ccggccctaa aatcccggct cagcatcacc agggacacct ccaagagcca agtctccctg      240

tcactgagca gcgtgacaac tgaggatacg gccgtgtact actgtgcgag aggtattatc      300

gccggtgtag atgtctgggg ccgaggactc ctggtcaccg tctcctca                   348


<210>  584
<211>  330
<212>  DNA
<213>  artificial sequence

<220>
<223>  412E10 VL Nucleotide Sequence

<400>  584
caggctgtgc tgactcagcc gtcctccgtg tctgggtccc tgggccagag ggtctccatc       60

acctgctctg gaagcagcag caacgttgga tatggtaatt atgtgggctg gtaccaacag      120

gtcccaggat cagcccccaa actcctcatc tatggtacag ccattcgagc ctcgggggtc      180

cccgaccgat tctccggctc caggtctggg gacacagcca cccttaccat cacctcgctc      240

caggctgagg acgaggccga ttactactgt gcatcttatc agagtaatta cgcttttttc      300

ggcagcggga ccaggctgac cgtcctgggt                                       330


<210>  585
<211>  372
<212>  DNA
<213>  artificial sequence

<220>
<223>  CE2 VH Nucleotide Sequence

<400>  585
caggtgcagc tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccctc       60

acctgcacgg tctctggatt ctcattaacc aactatcctg taggctgggt ccgccaggct      120

ccaggaaagg cactggagtg gattggtaac atagaaaatg atggaagtgc gaactatgcc      180

tcggccctga aatcccgact cagcatcacc agggacacct ccaagaacca agtctccctg      240

tcactgagca gcgcgacaac tgaggacacg gccgtttact actgtggaag agaattcggt      300

gggagtgatg gttatactta tttcgttgat atcgactact ggggcccagg actcctggtc      360

accgtctcct ca                                                          372


<210>  586
<211>  333
<212>  DNA
<213>  artificial sequence

<220>
<223>  CE2 VL Nucleotide Sequence

<400>  586
caggctgtgc tgactcagcc gtcctccgtg tccaagtccc tgggccagag tgtctccatc       60

acctgctctg gaagcagcag caacgttgga tatggtaatt atgtgagctg gttccaacag      120

gtcccaggat cagcccccaa aatcctcatc tatggtgcaa ccagtcgagc ctcgggggtc      180

cccgaccgat tctccggctc caggtctggc aacacagcga ctctgaccat cacctcgctc      240

caggctgagg acgaggccga ttattactgt gcatcttatg acggcagtag cagtggtgtt      300

ttcggcagcg ggaccaggct gaccgtcctg ggt                                   333


<210>  587
<211>  372
<212>  DNA
<213>  artificial sequence

<220>
<223>  CE3 VH Nucleotide Sequence

<400>  587
caggtgcgac tgcaggagtc gggacccagc ctggtgaagc cctcacagac cctctccgtc       60

acctgcacgg tctctggatt ctcattgatc agcaatgctg taggctgggt ccgccaggct      120

ccaggaaagg tgccggagtc gcttgctggt tgtagcagtg atggaaagtg ttactataac      180

tcggccctga aatcccggct cgacatcacc agggacacct cgaagaacca gatctccctg      240

tcactgagca gcgtcacaac tgacgacgcg gccgtgtact actgtacaag aggctattat      300

cctgtttatg gttatgacta tcttggcact atcgactact ggggccccgg actcctggtc      360

accgtctcct ca                                                          372


<210>  588
<211>  333
<212>  DNA
<213>  artificial sequence

<220>
<223>  CE3 VL Nucleotide Sequence

<400>  588
caagctgtgc tgactcaacc gtcctccgtg tctgggtccc tgggccagag ggtctccatc       60

acctgctctg gaagcagcag caacgttggt agaaatgatg tagcctggtt ccaacaactc      120

ccaggatcag gcctcagaac catcatctat ggtactacca gtcgaccctc aggtatcccg      180

gaccgattct ccggctccaa gtctggcgtt acggccaccc tgaccatcga ctcgctccag      240

gctgaggacg aggccgatta tttctgtgcc tctggtgaca gtagtgccat taatgatatt      300

ttcggcagcg ggaccaggct gaccgtcctg ggt                                   333


<210>  589
<211>  430
<212>  PRT
<213>  Mus musculus

<400>  589

Met Ala Asp Pro Arg Gln Glu Phe Asp Thr Met Glu Asp His Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Leu Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Glu Ser Pro Pro Gln Pro Pro Ala Asp Asp Gly Ala Glu Glu Pro 
        35                  40                  45              


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val 
    50                  55                  60                  


Thr Ala Pro Leu Val Asp Glu Arg Ala Pro Asp Lys Gln Ala Ala Ala 
65                  70                  75                  80  


Gln Pro His Thr Glu Ile Pro Glu Gly Ile Thr Ala Glu Glu Ala Gly 
                85                  90                  95      


Ile Gly Asp Thr Pro Asn Gln Glu Asp Gln Ala Ala Gly His Val Thr 
            100                 105                 110         


Gln Ala Arg Val Ala Ser Lys Asp Arg Thr Gly Asn Asp Glu Lys Lys 
        115                 120                 125             


Ala Lys Gly Ala Asp Gly Lys Thr Gly Ala Lys Ile Ala Thr Pro Arg 
    130                 135                 140                 


Gly Ala Ala Ser Pro Ala Gln Lys Gly Thr Ser Asn Ala Thr Arg Ile 
145                 150                 155                 160 


Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr Pro Pro Gly Ser Gly Glu 
                165                 170                 175     


Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
            180                 185                 190         


Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro 
        195                 200                 205             


Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser 
    210                 215                 220                 


Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro 
225                 230                 235                 240 


Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys 
                245                 250                 255     


His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
            260                 265                 270         


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
        275                 280                 285             


Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu 
    290                 295                 300                 


Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys 
305                 310                 315                 320 


Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys 
                325                 330                 335     


Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
            340                 345                 350         


Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
        355                 360                 365             


Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys 
    370                 375                 380                 


Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val 
385                 390                 395                 400 


Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
                405                 410                 415     


Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            420                 425                 430 


