                         SEQUENCE LISTING

<110>  WisTa Laboratories Ltd.
 
<120>  System for study of tau aggregation

<130>  P136457WO

<150>  GB2010620.9
<151>  2020-07-10

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  2
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser 
            500                 505                 510         


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
        515                 520                 525             


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
    530                 535                 540                 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
545                 550                 555                 560 


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
                565                 570                 575     


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            580                 585                 590         


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        595                 600                 605             


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    610                 615                 620                 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
625                 630                 635                 640 


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                645                 650                 655     


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            660                 665                 670         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        675                 680                 685             


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
    690                 695                 700                 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
705                 710                 715                 720 


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
                725                 730                 735     


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
            740                 745                 750         


Leu Ala Lys Gln Gly Leu 
        755             


<210>  3
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr 
1               5                   10                  15      


Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly 
            20                  25                  30          


Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu 
        35                  40                  45              


Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp 
    50                  55                  60                  


Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His 
65                  70                  75                  80  


Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
                85                  90                  95      


Glu 
    


<210>  4
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro 
1               5                   10                  15      


Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile 
            20                  25                  30          


His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
        35                  40                  45              


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
    50                  55                  60                  


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
65                  70                  75                  80  


Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu 
                85                  90                  95  


<210>  5
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro 
1               5                   10                  15      


Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile 
            20                  25                  30          


His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
        35                  40                  45              


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
    50                  55                  60                  


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
65                  70                  75                  80  


Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
                85                  90                  


<210>  6
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
        35                  40                  45              


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
    50                  55                  60                  


Lys Ile Glu Thr His Lys Leu Thr Phe 
65                  70              


<210>  7
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
1               5                   10                  15      


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
            20                  25                  30          


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
        35                  40                  45              


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
    50                  55                  60                  


Glu Thr His Lys Leu Thr Phe 
65                  70      


<210>  8
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 epitope

<400>  8

Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10              


<210>  9
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR1 S1D12

<400>  9

Asn Asn Ala Val Gly 
1               5   


<210>  10
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR2 S1D12

<400>  10

Gly Cys Ser Ser Asp Gly Thr Cys Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VHCDR3 S1D12

<400>  11

Gly His Tyr Ser Ile Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp Tyr 
1               5                   10                  15      


<210>  12
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR1 S1D12

<400>  12

Ser Gly Ser Ser Ser Asn Val Gly Gly Gly Asn Ser Val Gly 
1               5                   10                  


<210>  13
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR2 S1D12

<400>  13

Asp Thr Asn Ser Arg Pro Ser 
1               5           


<210>  14
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VLCDR3 S1D12

<400>  14

Val Thr Gly Asp Ser Thr Thr His Asp Asp Leu 
1               5                   10      


<210>  15
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH Domain S1D12

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Val Gly Cys Ser Ser Asp Gly Thr Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly His Tyr Ser Ile Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser 
        115                 120             


<210>  16
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL Domain S1D12

<400>  16

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Gly Gly 
            20                  25                  30          


Asn Ser Val Gly Trp Tyr Gln His Leu Pro Gly Ser Gly Leu Lys Thr 
        35                  40                  45              


Ile Ile Tyr Asp Thr Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Val Thr Gly Asp Ser Thr 
                85                  90                  95      


Thr His Asp Asp Leu Val Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  17
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 Heavy Chain

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Asn 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val Pro Glu Ser Leu 
        35                  40                  45              


Val Gly Cys Ser Ser Asp Gly Thr Cys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asp Ile Thr Arg Asp Thr Ser Lys Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Ser Leu Ser Ser Val Thr Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly His Tyr Ser Ile Tyr Gly Tyr Asp Tyr Leu Gly Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Ala Lys Thr Thr 
        115                 120                 125             


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
    130                 135                 140                 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
            180                 185                 190         


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
    210                 215                 220                 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
        355                 360                 365             


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
    370                 375                 380                 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
385                 390                 395                 400 


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
                405                 410                 415     


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
            420                 425                 430         


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
        435                 440                 445             


Ser Arg Thr Pro Gly Lys 
    450                 


<210>  18
<211>  218
<212>  PRT
<213>  artificial sequence

<220>
<223>  S1D12 Light Chain

<400>  18

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Gly Gly 
            20                  25                  30          


Asn Ser Val Gly Trp Tyr Gln His Leu Pro Gly Ser Gly Leu Lys Thr 
        35                  40                  45              


Ile Ile Tyr Asp Thr Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Val Thr Gly Asp Ser Thr 
                85                  90                  95      


Thr His Asp Asp Leu Val Gly Ser Gly Thr Arg Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro 
145                 150                 155                 160 


Val Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu 
            180                 185                 190         


Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val 
        195                 200                 205             


Glu Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215             


