                               SEQUENCE LISTING

<110> F. HOFFMANN-LA ROCHE AG
      ROCHE DIAGNOSTICS GMBH
      ROCHE SEQUENCING SOLUTIONS, INC.
      KAPA BIOSYSTEMS, INC.
 
<120> TARGETED DEPLETION OF NON-TARGET LIBRARY MOLECULES USING POISON 
      PRIMERS DURING TARGET CAPTURE OF NEXT-GENERATION SEQUENCING 
      LIBRARIES

<130> P35925-WO

<140>
<141>

<150> US 63/049,255
<151> 2020-07-08

<160> 98    

<170> PatentIn version 3.5

<210> 1
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 1
gatccaccgc taagagtc                                                     18


<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 2
cattaattct cgcagctagc                                                   20


<210> 3
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 3
tgtctgagcg tcgctt                                                       16


<210> 4
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 4
gtggtatggc cgtagac                                                      17


<210> 5
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 5
gggtgctgta ggcttt                                                       16


<210> 6
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 6
ggcaggatca accaggta                                                     18


<210> 7
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 7
cactgtaccg gccgtg                                                       16


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 8
ataactgtgg taattctaga gcta                                              24


<210> 9
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 9
aaatgcacgc atcccc                                                       16


<210> 10
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 10
taacctcggg ccgatc                                                       16


<210> 11
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 11
gcgactacca tcgaaagt                                                     18


<210> 12
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 12
ggggaggtag tgacgaa                                                      17


<210> 13
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 13
caattacagg gcctcgaa                                                     18


<210> 14
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 14
gatcttggga gcgggc                                                       16


<210> 15
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 15
aagagcatcg aggggg                                                       16


<210> 16
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 16
ctattttgtt ggttttcgga ac                                                22


<210> 17
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 17
cgccggtcca agaattt                                                      17


<210> 18
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 18
ataaacgatg ccgaccg                                                      17


<210> 19
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 19
ccggaaccca aagacttt                                                     18


<210> 20
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 20
ggacacggac aggattg                                                      17


<210> 21
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 21
aaagagctat caatctgtca atc                                               23


<210> 22
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 22
tgctaactag ttacgcgac                                                    19


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 23
catcacagac ctgttattgc                                                   20


<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 24
ttgcaattat tccccatgaa c                                                 21


<210> 25
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 25
gcacttactg ggaattcct                                                    19


<210> 26
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 26
gagcgctgag aagacg                                                       16


<210> 27
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 27
cttttacttc ctctagatag tcaag                                             25


<210> 28
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 28
ctgatctgag gtcgcg                                                       16


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 29
gggaatcctg gttagtttct t                                                 21


<210> 30
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 30
gcccaagtcc ttctgatc                                                     18


<210> 31
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 31
ccaagcaacc cgactc                                                       16


<210> 32
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 32
taaacgggtg gggtcc                                                       16


<210> 33
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 33
gccgggttga atcctc                                                       16


<210> 34
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 34
cctcctcctc ctcccc                                                       16


<210> 35
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 35
ggggggctgt aacact                                                       16


<210> 36
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 36
gtgggtagcc gacgtc                                                       16


<210> 37
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 37
tctccagtcc gccgag                                                       16


<210> 38
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 38
ctcgtgctcc acctcc                                                       16


<210> 39
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 39
cgtccgacct gggtata                                                      17


<210> 40
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 40
cagctatcct gagggaaac                                                    19


<210> 41
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 41
ggaatgcgag tgcctag                                                      17


<210> 42
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 42
ccttaacccg gcgttc                                                       16


<210> 43
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 43
cacctgccga atcaact                                                      17


<210> 44
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 44
gctcccgtcc actctc                                                       16


<210> 45
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 45
ctcctactcg tcgcgg                                                       16


<210> 46
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 46
gagaagggtt ccatgtgaa                                                    19


<210> 47
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 47
ccgactgacc catgttc                                                      17


<210> 48
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 48
ggattcgggg atctgaac                                                     18


<210> 49
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 49
gttcgccccg agagag                                                       16


<210> 50
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 50
gacgctttcc aaggca                                                       16


<210> 51
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 51
ccaaggtgaa cagcctc                                                      17


<210> 52
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 52
ggcttgccga cttccc                                                       16


<210> 53
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 53
ctcgcgtcca gagtcg                                                       16


<210> 54
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 54
taagtcggct gctaggc                                                      17


<210> 55
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 55
gcgggagtaa ctatgactc                                                    19


<210> 56
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 56
catgcgcgtc actaattag                                                    19


<210> 57
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 57
gaataagtgg gaggccc                                                      17


<210> 58
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 58
accgggtcag tgaaaaaa                                                     18


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 59
tacacctgtc aaacggtaac                                                   20


<210> 60
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 60
ttctgtcctc cctgagc                                                      17


<210> 61
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 61
ccaagcgttc atagcga                                                      17


<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 62
tcacaatgat aggaagagcc                                                   20


<210> 63
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 63
gttttaccct actgatgatg tg                                                22


<210> 64
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 64
ctcagccaag cacataca                                                     18


<210> 65
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 65
gttggcctcg gatagc                                                       16


<210> 66
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 66
gttccccacg aacgtg                                                       16


<210> 67
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 67
tcgacacaag ggtttgtc                                                     18


<210> 68
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 68
aggctaggac caaacctat                                                    19


<210> 69
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 69
cagctcaaaa cgcttagc                                                     18


<210> 70
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 70
aaggttaatc actgctgttt c                                                 21


<210> 71
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 71
atagaagccg gcgtaaag                                                     18


<210> 72
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 72
ttattgggga gggggtg                                                      17


<210> 73
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 73
gcttagccct aaacctcaa                                                    19


<210> 74
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 74
ggctcgtagt gttctgg                                                      17


<210> 75
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 75
atataccgcc atcttcagc                                                    19


<210> 76
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 76
tgtagccttc atcagggt                                                     18


<210> 77
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 77
gaaaactacg atagccctta tg                                                22


<210> 78
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 78
gtgtgtacgc gcttca                                                       16


<210> 79
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 79
agtgcacttg gacgaac                                                      17


<210> 80
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 80
ggtttggggc taggtttag                                                    19


<210> 81
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 81
gcaatagata tagtaccgca ag                                                22


<210> 82
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 82
cttgctatat tatgcttggt tataatt                                           27


<210> 83
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 83
ctaaaagagc acacccgt                                                     18


<210> 84
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 84
cttggacaac cagctatca                                                    19


<210> 85
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 85
ctaggaaaaa accttgtaga gag                                               23


<210> 86
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 86
tgagcttgaa cgctttct                                                     18


<210> 87
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 87
aatgttagta taagtaacat gaaaacat                                          28


<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 88
ttaatctgac gcaggcttat                                                   20


<210> 89
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 89
gaaaggttaa aaaaagtaaa aggaac                                            26


<210> 90
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 90
aacaggcggg gtaagat                                                      17


<210> 91
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 91
gttcagctgt ctcttacttt taa                                               23


<210> 92
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 92
tgttatgccc gcctct                                                       16


<210> 93
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 93
gagcagaacc caacctc                                                      17


<210> 94
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 94
tgtactgctc ggaggtt                                                      17


<210> 95
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 95
acaatagggt ttacgacctc                                                   20


<210> 96
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 96
ctgcaccatc gggatg                                                       16


<210> 97
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 97
gtacgaaagg acaagagaaa taa                                               23


<210> 98
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Synthetic poison primer"

<400> 98
gtgggtataa tactaagttg agatg                                             25


