                         SEQUENCE LISTING

<110>  Evonik Operations GmbH
 
<120>  Method for the fermentative production of guanidinoacetic acid

<130>  201900349

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  2205
<212>  DNA
<213>  Arabidopsis thaliana


<220>
<221>  CDS
<222>  (425)..(1870)
<223>  GGT1

<400>  1
ctcttcgtct ggaatctcca ccacattttt attctcttca aaaattatct gcttctattt       60

ttataattaa gcaagaacgg tcttcgtagc ataaaaacga gacacggata tagagatatc      120

gtgaattgac ttttgtctga caaatcctct tcgtcaattt cagtggctct gctgcttcct      180

ttgttgtgaa gccacataga ttagattgag gaatgatcca aactcatgtc atacacacat      240

ttgtaatctg ctacacaaaa tacttttaaa atcacacaca ctaatatttt aactctcccc      300

actctttgcc ttgcccttgg ctctagaacc gaacgtgact ctccagatag acttttggag      360

tcacaacatt gagtttgaag aggagggaag aagtgagcta gggattggtt cagagtgaac      420

ataa atg gct ctc aag gca tta gac tac gat act ctg aat gaa aac gtc       469
     Met Ala Leu Lys Ala Leu Asp Tyr Asp Thr Leu Asn Glu Asn Val          
     1               5                   10                  15           

aag aag tgt cag tat gcc gta aga ggt gaa ctt tat ctc cga gct tct        517
Lys Lys Cys Gln Tyr Ala Val Arg Gly Glu Leu Tyr Leu Arg Ala Ser           
                20                  25                  30                

gag ctg cag aaa gaa ggc aaa aag att att ttc aca aac gtt ggg aac        565
Glu Leu Gln Lys Glu Gly Lys Lys Ile Ile Phe Thr Asn Val Gly Asn           
            35                  40                  45                    

cct cat gct tta gga cag aag cca ttg aca ttt cct cgc cag gtg gtt        613
Pro His Ala Leu Gly Gln Lys Pro Leu Thr Phe Pro Arg Gln Val Val           
        50                  55                  60                        

gcg ctt tgc caa gct ccg ttt cta cta gat gac cca aat gtt gga atg        661
Ala Leu Cys Gln Ala Pro Phe Leu Leu Asp Asp Pro Asn Val Gly Met           
    65                  70                  75                            

cta ttt cca gct gat gct att gca aga gct aaa cat tat ctt tcc ttg        709
Leu Phe Pro Ala Asp Ala Ile Ala Arg Ala Lys His Tyr Leu Ser Leu           
80                  85                  90                  95            

act tca ggc ggt tta ggt gct tac agt gat tca aga ggc ctt cca gga        757
Thr Ser Gly Gly Leu Gly Ala Tyr Ser Asp Ser Arg Gly Leu Pro Gly           
                100                 105                 110               

gtt agg aaa gag gtt gct gag ttc att caa cgg cgt gat ggg tat cca        805
Val Arg Lys Glu Val Ala Glu Phe Ile Gln Arg Arg Asp Gly Tyr Pro           
            115                 120                 125                   

agt gac cca gaa ctc atc ttt ctc act gat gga gct agc aaa ggt gtg        853
Ser Asp Pro Glu Leu Ile Phe Leu Thr Asp Gly Ala Ser Lys Gly Val           
        130                 135                 140                       

atg caa atc ttg aat tgt gtt ata cgc ggt aat gga gat ggg att cta        901
Met Gln Ile Leu Asn Cys Val Ile Arg Gly Asn Gly Asp Gly Ile Leu           
    145                 150                 155                           

gtt ccg gtt cca cag tat cca ctt tac tca gct acc ata tca ctg tta        949
Val Pro Val Pro Gln Tyr Pro Leu Tyr Ser Ala Thr Ile Ser Leu Leu           
160                 165                 170                 175           

ggt ggt act ctt gtt cct tac tat ctt gat gag tct gaa aac tgg gga        997
Gly Gly Thr Leu Val Pro Tyr Tyr Leu Asp Glu Ser Glu Asn Trp Gly           
                180                 185                 190               

ctt gat gtt gct aac ctt cga caa tcc gtt gct cag gct cgt tct caa       1045
Leu Asp Val Ala Asn Leu Arg Gln Ser Val Ala Gln Ala Arg Ser Gln           
            195                 200                 205                   

ggg ata aca gta agg gca atg gtg atc att aac cct ggg aac cca act       1093
Gly Ile Thr Val Arg Ala Met Val Ile Ile Asn Pro Gly Asn Pro Thr           
        210                 215                 220                       

ggc cag tgt cta agc gaa gct aac ata aga gag ata ttg aag ttc tgt       1141
Gly Gln Cys Leu Ser Glu Ala Asn Ile Arg Glu Ile Leu Lys Phe Cys           
    225                 230                 235                           

tat aac gag aaa ctg gtt ctt ctg gga gac gag gtt tat cag cag aac       1189
Tyr Asn Glu Lys Leu Val Leu Leu Gly Asp Glu Val Tyr Gln Gln Asn           
240                 245                 250                 255           

ata tac cag gat gag cgt ccc ttt atc agc tcc aag aag gtt ttg atg       1237
Ile Tyr Gln Asp Glu Arg Pro Phe Ile Ser Ser Lys Lys Val Leu Met           
                260                 265                 270               

gaa atg ggt tcg ccg ttc agc aag gaa gtt cag ctt gta tct ttt cac       1285
Glu Met Gly Ser Pro Phe Ser Lys Glu Val Gln Leu Val Ser Phe His           
            275                 280                 285                   

aca gtc tct aaa gga tat tgg ggt gaa tgt gga cag cga ggt gga tac       1333
Thr Val Ser Lys Gly Tyr Trp Gly Glu Cys Gly Gln Arg Gly Gly Tyr           
        290                 295                 300                       

ttt gag atg acc aac ctc cct cca agg gtt gtt gag gag ata tac aag       1381
Phe Glu Met Thr Asn Leu Pro Pro Arg Val Val Glu Glu Ile Tyr Lys           
    305                 310                 315                           

gtt gca tca att gcc ctc agc cct aat gtc tct gcg caa atc ttt atg       1429
Val Ala Ser Ile Ala Leu Ser Pro Asn Val Ser Ala Gln Ile Phe Met           
320                 325                 330                 335           

ggt ttg atg gtt aat cct cca aag cct gga gac att tca tat gac cag       1477
Gly Leu Met Val Asn Pro Pro Lys Pro Gly Asp Ile Ser Tyr Asp Gln           
                340                 345                 350               

ttc gcc cgt gaa agc aag ggg att ctt gaa tct ttg aga aga aga gca       1525
Phe Ala Arg Glu Ser Lys Gly Ile Leu Glu Ser Leu Arg Arg Arg Ala           
            355                 360                 365                   

agg ctc atg aca gat gga ttc aac agc tgc aaa aac gtc gtg tgc aat       1573
Arg Leu Met Thr Asp Gly Phe Asn Ser Cys Lys Asn Val Val Cys Asn           
        370                 375                 380                       

ttc aca gaa ggt gca atg tat tcg ttt cct caa ata cgg tta cca acg       1621
Phe Thr Glu Gly Ala Met Tyr Ser Phe Pro Gln Ile Arg Leu Pro Thr           
    385                 390                 395                           

gga gct ctc caa gct gca aaa caa gct gga aaa gtg cca gac gtt ttc       1669
Gly Ala Leu Gln Ala Ala Lys Gln Ala Gly Lys Val Pro Asp Val Phe           
400                 405                 410                 415           

tac tgt ctc aag ctc tta gaa gcc aca gga atc tcc aca gta cct ggc       1717
Tyr Cys Leu Lys Leu Leu Glu Ala Thr Gly Ile Ser Thr Val Pro Gly           
                420                 425                 430               

tct gga ttt gga cag aaa gaa ggt gtg ttc cat ctg agg aca aca atc       1765
Ser Gly Phe Gly Gln Lys Glu Gly Val Phe His Leu Arg Thr Thr Ile           
            435                 440                 445                   

ctg cca gca gaa gat gag atg ccg gag atc atg gat agc ttc aag aag       1813
Leu Pro Ala Glu Asp Glu Met Pro Glu Ile Met Asp Ser Phe Lys Lys           
        450                 455                 460                       

ttc aac gac gag ttc atg act cag tat gat aat aac ttt ggt tat tcg       1861
Phe Asn Asp Glu Phe Met Thr Gln Tyr Asp Asn Asn Phe Gly Tyr Ser           
    465                 470                 475                           

aaa atg tga ttacttcttc ttctgaacga ctattgtgtt ctgctacact               1910
Lys Met                                                                   
480                                                                       

ctttaaagct aaatctctgt agtacactct ttctctttgc cctattctat aaaccatatc     1970

tctctctttg tgtctctttt ttttgggtgt aaactctctc ttgtgtctct atttctattt     2030

tcaattggaa actgattaag atcttttctc aatgaaatga agtttaggcc atagattatt     2090

ttttttaatc aacggtgata gccttttttt agtgtggcaa tgtgaaattt gtaattatgc     2150

taattatatt aaagaaaata ataataatcc atgtcctagt ttgtttttga ttatg          2205


<210>  2
<211>  481
<212>  PRT
<213>  Arabidopsis thaliana

<400>  2

Met Ala Leu Lys Ala Leu Asp Tyr Asp Thr Leu Asn Glu Asn Val Lys 
1               5                   10                  15      


Lys Cys Gln Tyr Ala Val Arg Gly Glu Leu Tyr Leu Arg Ala Ser Glu 
            20                  25                  30          


Leu Gln Lys Glu Gly Lys Lys Ile Ile Phe Thr Asn Val Gly Asn Pro 
        35                  40                  45              


His Ala Leu Gly Gln Lys Pro Leu Thr Phe Pro Arg Gln Val Val Ala 
    50                  55                  60                  


Leu Cys Gln Ala Pro Phe Leu Leu Asp Asp Pro Asn Val Gly Met Leu 
65                  70                  75                  80  


Phe Pro Ala Asp Ala Ile Ala Arg Ala Lys His Tyr Leu Ser Leu Thr 
                85                  90                  95      


Ser Gly Gly Leu Gly Ala Tyr Ser Asp Ser Arg Gly Leu Pro Gly Val 
            100                 105                 110         


Arg Lys Glu Val Ala Glu Phe Ile Gln Arg Arg Asp Gly Tyr Pro Ser 
        115                 120                 125             


Asp Pro Glu Leu Ile Phe Leu Thr Asp Gly Ala Ser Lys Gly Val Met 
    130                 135                 140                 


Gln Ile Leu Asn Cys Val Ile Arg Gly Asn Gly Asp Gly Ile Leu Val 
145                 150                 155                 160 


Pro Val Pro Gln Tyr Pro Leu Tyr Ser Ala Thr Ile Ser Leu Leu Gly 
                165                 170                 175     


Gly Thr Leu Val Pro Tyr Tyr Leu Asp Glu Ser Glu Asn Trp Gly Leu 
            180                 185                 190         


Asp Val Ala Asn Leu Arg Gln Ser Val Ala Gln Ala Arg Ser Gln Gly 
        195                 200                 205             


Ile Thr Val Arg Ala Met Val Ile Ile Asn Pro Gly Asn Pro Thr Gly 
    210                 215                 220                 


Gln Cys Leu Ser Glu Ala Asn Ile Arg Glu Ile Leu Lys Phe Cys Tyr 
225                 230                 235                 240 


Asn Glu Lys Leu Val Leu Leu Gly Asp Glu Val Tyr Gln Gln Asn Ile 
                245                 250                 255     


Tyr Gln Asp Glu Arg Pro Phe Ile Ser Ser Lys Lys Val Leu Met Glu 
            260                 265                 270         


Met Gly Ser Pro Phe Ser Lys Glu Val Gln Leu Val Ser Phe His Thr 
        275                 280                 285             


Val Ser Lys Gly Tyr Trp Gly Glu Cys Gly Gln Arg Gly Gly Tyr Phe 
    290                 295                 300                 


Glu Met Thr Asn Leu Pro Pro Arg Val Val Glu Glu Ile Tyr Lys Val 
305                 310                 315                 320 


Ala Ser Ile Ala Leu Ser Pro Asn Val Ser Ala Gln Ile Phe Met Gly 
                325                 330                 335     


Leu Met Val Asn Pro Pro Lys Pro Gly Asp Ile Ser Tyr Asp Gln Phe 
            340                 345                 350         


Ala Arg Glu Ser Lys Gly Ile Leu Glu Ser Leu Arg Arg Arg Ala Arg 
        355                 360                 365             


Leu Met Thr Asp Gly Phe Asn Ser Cys Lys Asn Val Val Cys Asn Phe 
    370                 375                 380                 


Thr Glu Gly Ala Met Tyr Ser Phe Pro Gln Ile Arg Leu Pro Thr Gly 
385                 390                 395                 400 


Ala Leu Gln Ala Ala Lys Gln Ala Gly Lys Val Pro Asp Val Phe Tyr 
                405                 410                 415     


Cys Leu Lys Leu Leu Glu Ala Thr Gly Ile Ser Thr Val Pro Gly Ser 
            420                 425                 430         


Gly Phe Gly Gln Lys Glu Gly Val Phe His Leu Arg Thr Thr Ile Leu 
        435                 440                 445             


Pro Ala Glu Asp Glu Met Pro Glu Ile Met Asp Ser Phe Lys Lys Phe 
    450                 455                 460                 


Asn Asp Glu Phe Met Thr Gln Tyr Asp Asn Asn Phe Gly Tyr Ser Lys 
465                 470                 475                 480 


Met 
    


<210>  3
<211>  1560
<212>  DNA
<213>  synthetic DNA

<400>  3
ggtctcccaa gcttgcatgc ctgcaggtcg actctagagg atccgacgtc aggaaaggag       60

aggattgatg gcgctgaagg ccctcgatta cgacacgctg aatgagaacg tcaaaaaatg      120

ccaatatgct gtgcggggcg agttgtatct tcgtgcctcc gagctgcaaa aagagggcaa      180

aaagattatt ttcaccaacg taggaaatcc tcacgccttg ggccagaagc cacttacgtt      240

cccgcggcaa gttgttgcgc tttgccaagc accattcctg ctggatgatc ctaacgtagg      300

tatgttgttc ccggctgacg cgattgcccg ggctaagcat tacctgtctc tgacttcggg      360

tggtcttggc gcttactcgg attcacgcgg cttgccaggt gtccggaaag aggtggctga      420

gtttattcaa cggcgggacg gctacccatc agaccctgaa ctcatctttc ttacggatgg      480

tgcttctaaa ggtgtaatgc aaattctcaa ctgtgtgatt cgcggtaatg gagatggtat      540

ccttgtcccg gtcccacagt atccactgta ctccgcgact atttctcttc tcggcggaac      600

gctggttccg tattatttgg acgaatcgga gaattggggc ctcgacgtag ccaaccttcg      660

tcagagcgtc gcacaggcgc gttcacaagg catcactgtc cgggcgatgg ttattattaa      720

cccgggaaac ccgactggac aatgcttgag cgaagcaaat attcgtgaga tccttaaatt      780

ttgctacaac gagaagctgg tactcctcgg agatgaggtt taccaacaaa acatttatca      840

ggatgaacgg ccttttatct cgtcaaagaa ggtactgatg gagatgggtt ctcctttcag      900

caaagaagta cagctggtca gcttccatac tgtctctaag ggttattggg gtgaatgtgg      960

ccagcgcggc ggctacttcg aaatgactaa cctcccccct cgcgtcgtgg aagagatcta     1020

taaggttgca tctattgctt tgtcgcccaa cgtatcggcc cagatcttta tgggactgat     1080

ggtaaacccc cctaaacctg gagacattag ctacgaccag ttcgcgcgtg aatctaaggg     1140

tatccttgaa tcccttcgtc gccgcgcgcg tctgatgact gacggattca attcatgtaa     1200

gaacgtagta tgcaacttca cggaaggcgc gatgtactct ttcccccaga tccgtcttcc     1260

aaccggtgca ctccaggctg ctaagcaggc gggaaaggtg cccgatgtgt tttattgtct     1320

caaattgttg gaggcgaccg gcatctccac tgttccaggc agcggctttg gacagaagga     1380

gggagttttt catctgcgta cgactatcct tcctgccgag gatgagatgc ctgaaattat     1440

ggattctttc aagaagttta acgacgagtt catgactcaa tatgacaata atttcggata     1500

ctccaaaatg taataaggat ccccgggtac cgagctcgaa ttcactggcc gtcggagacc     1560


<210>  4
<211>  1817
<212>  DNA
<213>  Arabidopsis thaliana


<220>
<221>  CDS
<222>  (148)..(1593)
<223>  GGT2

<400>  4
ataaaaaacc aatctttatg atcgactcaa taagtcaaat cttgttgtgt taagtgaaat       60

ctatagtagt gaaagggtct ccacttagct gtttgagggg aagtgaggaa tcattttgct      120

tttagctttg aaaagtaaat cctggaa atg tct ctc aag gcg tta gac tac gag      174
                              Met Ser Leu Lys Ala Leu Asp Tyr Glu         
                              1               5                           

tcc ttg aat gaa aac gtg aag aat tgt cag tat gca gtc aga ggt gaa        222
Ser Leu Asn Glu Asn Val Lys Asn Cys Gln Tyr Ala Val Arg Gly Glu           
10                  15                  20                  25            

ctt tat ctt cgt gct tct gag ctt cag aaa gaa ggc aaa aag att att        270
Leu Tyr Leu Arg Ala Ser Glu Leu Gln Lys Glu Gly Lys Lys Ile Ile           
                30                  35                  40                

ttc aca aat gtt gga aac cct cat gct tta gga cag aaa cct ctg act        318
Phe Thr Asn Val Gly Asn Pro His Ala Leu Gly Gln Lys Pro Leu Thr           
            45                  50                  55                    

ttt cct cgt cag gtg gtt tct tta tgc caa gca cca ttt ctg tta gat        366
Phe Pro Arg Gln Val Val Ser Leu Cys Gln Ala Pro Phe Leu Leu Asp           
        60                  65                  70                        

gat cca aat gtt ggt atg ata ttc cca gca gat gct att gca aga gct        414
Asp Pro Asn Val Gly Met Ile Phe Pro Ala Asp Ala Ile Ala Arg Ala           
    75                  80                  85                            

aag cat tat ctt tcc ttg act tct ggt ggt ctt ggt gct tac agt gac        462
Lys His Tyr Leu Ser Leu Thr Ser Gly Gly Leu Gly Ala Tyr Ser Asp           
90                  95                  100                 105           

tca aga ggt ctt ccg gga gtt cgg aaa gaa gtc gct gag ttc att gaa        510
Ser Arg Gly Leu Pro Gly Val Arg Lys Glu Val Ala Glu Phe Ile Glu           
                110                 115                 120               

cgg cgt gat gga tat cca agc gat cca gaa ctc ata ttt cta act gat        558
Arg Arg Asp Gly Tyr Pro Ser Asp Pro Glu Leu Ile Phe Leu Thr Asp           
            125                 130                 135                   

gga gcg agc aaa ggt gtg atg caa atc ttg aat tgt gtc ata cgc ggt        606
Gly Ala Ser Lys Gly Val Met Gln Ile Leu Asn Cys Val Ile Arg Gly           
        140                 145                 150                       

cag aaa gac gga att ctg gtt cca gtt cca cag tat cca ctc tac tcg        654
Gln Lys Asp Gly Ile Leu Val Pro Val Pro Gln Tyr Pro Leu Tyr Ser           
    155                 160                 165                           

gct act ata tct ctg tta ggt ggt act ctt gtt cct tac tat ctt gaa        702
Ala Thr Ile Ser Leu Leu Gly Gly Thr Leu Val Pro Tyr Tyr Leu Glu           
170                 175                 180                 185           

gag tct gaa aac tgg gga ctt gat gtt aac aac ctt cgc caa tct gtt        750
Glu Ser Glu Asn Trp Gly Leu Asp Val Asn Asn Leu Arg Gln Ser Val           
                190                 195                 200               

gct caa gct cgc tct caa gga ata aca gta agg gca atg gtg att att        798
Ala Gln Ala Arg Ser Gln Gly Ile Thr Val Arg Ala Met Val Ile Ile           
            205                 210                 215                   

aac ccc gga aac cca act ggc cag tgt ctt agc gaa gct aac ata aga        846
Asn Pro Gly Asn Pro Thr Gly Gln Cys Leu Ser Glu Ala Asn Ile Arg           
        220                 225                 230                       

gag ata cta cgg ttc tgt tgt gat gag aga tta gtt ctt ctc gga gac        894
Glu Ile Leu Arg Phe Cys Cys Asp Glu Arg Leu Val Leu Leu Gly Asp           
    235                 240                 245                           

gaa gtg tat cag caa aat ata tac caa gat gaa cgt ccc ttt atc agt        942
Glu Val Tyr Gln Gln Asn Ile Tyr Gln Asp Glu Arg Pro Phe Ile Ser           
250                 255                 260                 265           

tcc aag aag gtt ttg atg gat atg gga gca ccg atc agc aag gaa gtt        990
Ser Lys Lys Val Leu Met Asp Met Gly Ala Pro Ile Ser Lys Glu Val           
                270                 275                 280               

cag ctc ata tct ttc cac acc gtt tcc aaa gga tac tgg ggc gaa tgt       1038
Gln Leu Ile Ser Phe His Thr Val Ser Lys Gly Tyr Trp Gly Glu Cys           
            285                 290                 295                   

ggg caa cgg gga ggt tac ttt gag atg aca aat atc cct ccc agg acc       1086
Gly Gln Arg Gly Gly Tyr Phe Glu Met Thr Asn Ile Pro Pro Arg Thr           
        300                 305                 310                       

gtt gag gag ata tac aag gtg gcc tct ata gct ctc agc ccc aac gtc       1134
Val Glu Glu Ile Tyr Lys Val Ala Ser Ile Ala Leu Ser Pro Asn Val           
    315                 320                 325                           

tct gcg cag ata ttt atg ggt tta atg gtt agc cca cca aag cct gga       1182
Ser Ala Gln Ile Phe Met Gly Leu Met Val Ser Pro Pro Lys Pro Gly           
330                 335                 340                 345           

gac att tca tat gac caa ttc gtt cgt gag agc aag gga ata cta gaa       1230
Asp Ile Ser Tyr Asp Gln Phe Val Arg Glu Ser Lys Gly Ile Leu Glu           
                350                 355                 360               

tca ctg aga aga aga gca agg atg atg act gat gga ttc aac agc tgc       1278
Ser Leu Arg Arg Arg Ala Arg Met Met Thr Asp Gly Phe Asn Ser Cys           
            365                 370                 375                   

aaa aac gtc gtc tgt aat ttc aca gaa ggt gct atg tat tca ttc cct       1326
Lys Asn Val Val Cys Asn Phe Thr Glu Gly Ala Met Tyr Ser Phe Pro           
        380                 385                 390                       

caa ata aag ttg ccg tcg aaa gca atc caa gca gca aaa caa gcc gga       1374
Gln Ile Lys Leu Pro Ser Lys Ala Ile Gln Ala Ala Lys Gln Ala Gly           
    395                 400                 405                           

aaa gtc cct gac gtt ttc tac tgc ctt aag ctc tta gaa gcc aca gga       1422
Lys Val Pro Asp Val Phe Tyr Cys Leu Lys Leu Leu Glu Ala Thr Gly           
410                 415                 420                 425           

atc tcc aca gtt cca ggc tct gga ttt gga caa aaa gaa ggg gtg ttt       1470
Ile Ser Thr Val Pro Gly Ser Gly Phe Gly Gln Lys Glu Gly Val Phe           
                430                 435                 440               

cat tta agg aca aca att ctg cca gca gaa gaa gaa atg cca gag att       1518
His Leu Arg Thr Thr Ile Leu Pro Ala Glu Glu Glu Met Pro Glu Ile           
            445                 450                 455                   

atg gac agt ttc aaa aag ttc aat gat gag ttt atg tct cag tac gct       1566
Met Asp Ser Phe Lys Lys Phe Asn Asp Glu Phe Met Ser Gln Tyr Ala           
        460                 465                 470                       

gat aac ttt ggt tac tcc aga atg tga aaaagaaagg acttagagtc             1613
Asp Asn Phe Gly Tyr Ser Arg Met                                           
    475                 480                                               

agagtcagag atcacttctt cttctttcac gacattatta ttgtctattc acactcttaa     1673

aaagcaataa gtactggtcc tactctgtgt caaactcttc ttggtgctct taaaaccttt     1733

gtatctattg ttaccaattt gtgtgactca cacacacaca cacacaaatc tctaatgttc     1793

aattatatgg taaatggttt attt                                            1817


<210>  5
<211>  481
<212>  PRT
<213>  Arabidopsis thaliana

<400>  5

Met Ser Leu Lys Ala Leu Asp Tyr Glu Ser Leu Asn Glu Asn Val Lys 
1               5                   10                  15      


Asn Cys Gln Tyr Ala Val Arg Gly Glu Leu Tyr Leu Arg Ala Ser Glu 
            20                  25                  30          


Leu Gln Lys Glu Gly Lys Lys Ile Ile Phe Thr Asn Val Gly Asn Pro 
        35                  40                  45              


His Ala Leu Gly Gln Lys Pro Leu Thr Phe Pro Arg Gln Val Val Ser 
    50                  55                  60                  


Leu Cys Gln Ala Pro Phe Leu Leu Asp Asp Pro Asn Val Gly Met Ile 
65                  70                  75                  80  


Phe Pro Ala Asp Ala Ile Ala Arg Ala Lys His Tyr Leu Ser Leu Thr 
                85                  90                  95      


Ser Gly Gly Leu Gly Ala Tyr Ser Asp Ser Arg Gly Leu Pro Gly Val 
            100                 105                 110         


Arg Lys Glu Val Ala Glu Phe Ile Glu Arg Arg Asp Gly Tyr Pro Ser 
        115                 120                 125             


Asp Pro Glu Leu Ile Phe Leu Thr Asp Gly Ala Ser Lys Gly Val Met 
    130                 135                 140                 


Gln Ile Leu Asn Cys Val Ile Arg Gly Gln Lys Asp Gly Ile Leu Val 
145                 150                 155                 160 


Pro Val Pro Gln Tyr Pro Leu Tyr Ser Ala Thr Ile Ser Leu Leu Gly 
                165                 170                 175     


Gly Thr Leu Val Pro Tyr Tyr Leu Glu Glu Ser Glu Asn Trp Gly Leu 
            180                 185                 190         


Asp Val Asn Asn Leu Arg Gln Ser Val Ala Gln Ala Arg Ser Gln Gly 
        195                 200                 205             


Ile Thr Val Arg Ala Met Val Ile Ile Asn Pro Gly Asn Pro Thr Gly 
    210                 215                 220                 


Gln Cys Leu Ser Glu Ala Asn Ile Arg Glu Ile Leu Arg Phe Cys Cys 
225                 230                 235                 240 


Asp Glu Arg Leu Val Leu Leu Gly Asp Glu Val Tyr Gln Gln Asn Ile 
                245                 250                 255     


Tyr Gln Asp Glu Arg Pro Phe Ile Ser Ser Lys Lys Val Leu Met Asp 
            260                 265                 270         


Met Gly Ala Pro Ile Ser Lys Glu Val Gln Leu Ile Ser Phe His Thr 
        275                 280                 285             


Val Ser Lys Gly Tyr Trp Gly Glu Cys Gly Gln Arg Gly Gly Tyr Phe 
    290                 295                 300                 


Glu Met Thr Asn Ile Pro Pro Arg Thr Val Glu Glu Ile Tyr Lys Val 
305                 310                 315                 320 


Ala Ser Ile Ala Leu Ser Pro Asn Val Ser Ala Gln Ile Phe Met Gly 
                325                 330                 335     


Leu Met Val Ser Pro Pro Lys Pro Gly Asp Ile Ser Tyr Asp Gln Phe 
            340                 345                 350         


Val Arg Glu Ser Lys Gly Ile Leu Glu Ser Leu Arg Arg Arg Ala Arg 
        355                 360                 365             


Met Met Thr Asp Gly Phe Asn Ser Cys Lys Asn Val Val Cys Asn Phe 
    370                 375                 380                 


Thr Glu Gly Ala Met Tyr Ser Phe Pro Gln Ile Lys Leu Pro Ser Lys 
385                 390                 395                 400 


Ala Ile Gln Ala Ala Lys Gln Ala Gly Lys Val Pro Asp Val Phe Tyr 
                405                 410                 415     


Cys Leu Lys Leu Leu Glu Ala Thr Gly Ile Ser Thr Val Pro Gly Ser 
            420                 425                 430         


Gly Phe Gly Gln Lys Glu Gly Val Phe His Leu Arg Thr Thr Ile Leu 
        435                 440                 445             


Pro Ala Glu Glu Glu Met Pro Glu Ile Met Asp Ser Phe Lys Lys Phe 
    450                 455                 460                 


Asn Asp Glu Phe Met Ser Gln Tyr Ala Asp Asn Phe Gly Tyr Ser Arg 
465                 470                 475                 480 


Met 
    


<210>  6
<211>  1560
<212>  DNA
<213>  synthetic DNA

<400>  6
ggtctcccaa gcttgcatgc ctgcaggtcg actctagagg atccgacgtc aggaaaggag       60

aggattgatg tccctcaagg ctttggacta cgaatctttg aacgaaaacg ttaaaaattg      120

tcagtatgcg gtccggggtg aactctatct gcgtgcttcc gagttgcaaa aagagggtaa      180

aaaaatcatt tttactaacg tcggaaaccc acacgcattg ggacagaagc cacttacctt      240

tccacggcaa gttgtgtcgc tctgtcaggc tccttttttg ttggacgacc ccaacgtagg      300

tatgatcttt ccggcagatg ccatcgcccg ggcgaagcat tatttgtcac ttacctcggg      360

tggactcgga gcatattctg attcgcgggg actcccaggt gtacgtaaag aagtcgccga      420

gttcattgaa cgccgtgatg gctacccctc cgatccggaa ctcatttttc ttacggacgg      480

agcgtcgaaa ggagttatgc aaattctcaa ctgtgtgatt cgcggccaga aggatggtat      540

tctggtgcca gttccgcaat accctctgta ttccgcaact atttcgctcc tcggtggaac      600

gcttgtcccc tattatttgg aggagtccga gaattggggc ctcgacgtaa ataatctgcg      660

gcaatccgtt gctcaggccc ggtcgcaggg aattactgtt cgtgcgatgg tcatcatcaa      720

tcccggcaac ccgactggac aatgcctgtc cgaggctaac attcgcgaga ttctccgttt      780

ttgctgtgac gaacggttgg ttttgcttgg agatgaagtt tatcaacaaa atatttatca      840

ggacgagcgg ccattcatca gctcaaagaa ggtattgatg gatatgggcg ctccaattag      900

caaggaggtc cagcttatct catttcacac tgtttcgaag ggctactggg gcgaatgcgg      960

tcagcggggt ggttacttcg aaatgacgaa tatcccccca cgtaccgtgg aagagattta     1020

taaggttgcc tcgattgcac tttcgccaaa cgtatccgcg cagattttta tgggcctgat     1080

ggtatctccc ccaaagcccg gtgacatttc ctacgatcaa ttcgtgcggg aatcaaaagg     1140

aattcttgaa tcattgcgcc ggcgcgcccg tatgatgact gatggcttca atagctgcaa     1200

aaacgttgta tgcaacttta ccgagggtgc aatgtattct ttccctcaga ttaagctccc     1260

ttcgaaggct atccaggcgg cgaagcaagc gggaaaagtg ccagatgtct tttactgcct     1320

caaactgctg gaagcgaccg gaatctccac ggtcccgggc tctggattcg gccaaaagga     1380

aggagtattt catctccgga ctaccattct gccggccgag gaagaaatgc cagagatcat     1440

ggacagcttc aaaaaattca atgacgaatt tatgtcgcag tatgccgata acttcggcta     1500

ttcgcggatg taataaggat ccccgggtac cgagctcgaa ttcactggcc gtcggagacc     1560


<210>  7
<211>  2406
<212>  DNA
<213>  Thermococcus litoralis


<220>
<221>  CDS
<222>  (196)..(1419)
<223>  AGT

<400>  7
tctagaagca ctccccgtgg aggtgccttc ggatctttcc agagttctat ttcatagaat       60

ttctcaatca tcttaattcc attttccgga atttgtcgtg ttataaacac cttgggcttc      120

atggtatttc cccttctaag ataatggtca aaacgtataa atatctttat gaagattagt      180

taatggtgat gttga atg gat tac aca aaa tac cta gcc gga agg gcg aat       231
                 Met Asp Tyr Thr Lys Tyr Leu Ala Gly Arg Ala Asn          
                 1               5                   10                   

tgg att aag ggc tca gct ttg gct gat gtg atg aaa aag gct tca gaa        279
Trp Ile Lys Gly Ser Ala Leu Ala Asp Val Met Lys Lys Ala Ser Glu           
        15                  20                  25                        

ctc caa aag aaa ggg gta aag cta att tct ctc gca gct gga gat cca        327
Leu Gln Lys Lys Gly Val Lys Leu Ile Ser Leu Ala Ala Gly Asp Pro           
    30                  35                  40                            

gat ccg gag tta att cca aga gct gtt ctt ggg gaa ata gca aaa gaa        375
Asp Pro Glu Leu Ile Pro Arg Ala Val Leu Gly Glu Ile Ala Lys Glu           
45                  50                  55                  60            

gtt ctt gaa aag gaa cca aaa tcc gtt atg tat act ccg gca aat gga        423
Val Leu Glu Lys Glu Pro Lys Ser Val Met Tyr Thr Pro Ala Asn Gly           
                65                  70                  75                

atc ccg gag ctt agg gaa gag ctg gca gca ttc ttg aaa aaa tac gac        471
Ile Pro Glu Leu Arg Glu Glu Leu Ala Ala Phe Leu Lys Lys Tyr Asp           
            80                  85                  90                    

cat tta gaa gtt tct cca gaa aac att gtt att aca ata gga gga acg        519
His Leu Glu Val Ser Pro Glu Asn Ile Val Ile Thr Ile Gly Gly Thr           
        95                  100                 105                       

gga gca ttg gat ctt ctt gga agg gtt ttg ata gac cct gga gat gtc        567
Gly Ala Leu Asp Leu Leu Gly Arg Val Leu Ile Asp Pro Gly Asp Val           
    110                 115                 120                           

gtg ata aca gag aac cca tcg tac ata aac aca tta ttg gca ttt gaa        615
Val Ile Thr Glu Asn Pro Ser Tyr Ile Asn Thr Leu Leu Ala Phe Glu           
125                 130                 135                 140           

cag ttg gga gcc aaa att gag ggg gtt cca gtt gat aac gat ggg atg        663
Gln Leu Gly Ala Lys Ile Glu Gly Val Pro Val Asp Asn Asp Gly Met           
                145                 150                 155               

agg gtt gat ctg ttg gag gag aaa ata aag gag ctt aaa gct aaa gga        711
Arg Val Asp Leu Leu Glu Glu Lys Ile Lys Glu Leu Lys Ala Lys Gly           
            160                 165                 170                   

cag aaa gtt aag ctg atc tac acc atc ccg act ggt cag aat cca atg        759
Gln Lys Val Lys Leu Ile Tyr Thr Ile Pro Thr Gly Gln Asn Pro Met           
        175                 180                 185                       

ggc gtc act atg agc atg gaa cgg aga aag gca cta ctt gag att gcc        807
Gly Val Thr Met Ser Met Glu Arg Arg Lys Ala Leu Leu Glu Ile Ala           
    190                 195                 200                           

tct aaa tac gac ctc cta ata att gag gac act gct tat aat ttc atg        855
Ser Lys Tyr Asp Leu Leu Ile Ile Glu Asp Thr Ala Tyr Asn Phe Met           
205                 210                 215                 220           

aga tat gaa gga ggg gat ata gtc ccc tta aag gct ttg gac aat gaa        903
Arg Tyr Glu Gly Gly Asp Ile Val Pro Leu Lys Ala Leu Asp Asn Glu           
                225                 230                 235               

gga aga gtt atc gtg gcg gga acg ctc agc aaa gtc ctt gga aca gga        951
Gly Arg Val Ile Val Ala Gly Thr Leu Ser Lys Val Leu Gly Thr Gly           
            240                 245                 250                   

ttc aga att gga tgg ata ata gca gag gga gaa atc ctc aaa aaa gtt        999
Phe Arg Ile Gly Trp Ile Ile Ala Glu Gly Glu Ile Leu Lys Lys Val           
        255                 260                 265                       

ctc atg cag aaa cag cca att gac ttc tgt gct cca gct att tcc caa       1047
Leu Met Gln Lys Gln Pro Ile Asp Phe Cys Ala Pro Ala Ile Ser Gln           
    270                 275                 280                           

tac att gcc cta gaa tac tta aag agg ggc tat ttt gag aag tat cac       1095
Tyr Ile Ala Leu Glu Tyr Leu Lys Arg Gly Tyr Phe Glu Lys Tyr His           
285                 290                 295                 300           

ttg gaa gga gca ctg ctc ggt tat aaa gag aag agg gac atc atg ctg       1143
Leu Glu Gly Ala Leu Leu Gly Tyr Lys Glu Lys Arg Asp Ile Met Leu           
                305                 310                 315               

aag gct ctt gaa aat cac ttg cca aat gca gaa ttt aca aag cca ata       1191
Lys Ala Leu Glu Asn His Leu Pro Asn Ala Glu Phe Thr Lys Pro Ile           
            320                 325                 330                   

gcg gga atg ttt gtt atg ttt ttc ctt cca gag gga gca gat ggc atc       1239
Ala Gly Met Phe Val Met Phe Phe Leu Pro Glu Gly Ala Asp Gly Ile           
        335                 340                 345                       

tca ttt gcc aac gag ctc atg gaa agg gag gga gtt gtg gta gtt cca       1287
Ser Phe Ala Asn Glu Leu Met Glu Arg Glu Gly Val Val Val Val Pro           
    350                 355                 360                           

gga aag cct ttc tac aca gac gag tct gga aag aat gct ata agg ctt       1335
Gly Lys Pro Phe Tyr Thr Asp Glu Ser Gly Lys Asn Ala Ile Arg Leu           
365                 370                 375                 380           

aac ttc tca agg cca agc aag gaa gaa att cca ata gga atc aag aaa       1383
Asn Phe Ser Arg Pro Ser Lys Glu Glu Ile Pro Ile Gly Ile Lys Lys           
                385                 390                 395               

ctt gct aag ctt tat aag gaa aag ttt ggc gag tga attctttgtt            1429
Leu Ala Lys Leu Tyr Lys Glu Lys Phe Gly Glu                               
            400                 405                                       

tttacatttt cttctgggcc atcacattct cgatggagag aaggttagtt tgtttttaat     1489

gcactcagaa aagttctttt tggtgcgggg gcggggattt gaaccccgga acccctacgg     1549

gacgggaccc tcaatcccgc gcctttgacc aggctcggca acccccgcaa gagcgccgtt     1609

tatttgtctt cttagtttgt ttataaattt ttctgtcccc tttaaccggg gcgtgtttat     1669

agtaaccttt attagggttt ttgctgaatt ctttcaggtg gttgtcgtga tccccagatg     1729

ggatcacaaa ctcaaagacc ctgaaagcgt ggcattcata atcctcgacg ttttagcaga     1789

cttcgaatca gaaggaaagc tgaagaacct gccaaaaatc caaaaaattt ccagtaaaaa     1849

caatactggc aatactcctc tttaaacaat actacaacct acccctcaga gacgcccagc     1909

actacggcag aaaattcttc ggagcaaaca ttcactactc aaccctccac aactgggaga     1969

aaaagctgaa cctcgaagaa ctgacaaacc acctcctgaa aaaactccag aaattaccct     2029

acgccagcac tcaagcagac tcaaccatta tcacaaataa aaaaaggaca gaatagaagt     2089

tcaggcaata acgagaatcc tgccgggttt actgtatccg gttgctgtga agatcacaac     2149

ttctgagaac gagctgattg aactcctgcc ggagggttct gggaattttt atgctgatgg     2209

ggcttatgat tcaaagaaag ttctgaacac tgtggtggaa aagggttatc ggccgattgt     2269

taagaaaact aagaaccctc caggtggttt tggtagtaag aagagagata gagtgttttc     2329

tgaagaagag tacaggcata ggaatcctca tgaggggttc tggggtgcgt ttacaacgtg     2389

gtttggcagt aggatcc                                                    2406


<210>  8
<211>  407
<212>  PRT
<213>  Thermococcus litoralis

<400>  8

Met Asp Tyr Thr Lys Tyr Leu Ala Gly Arg Ala Asn Trp Ile Lys Gly 
1               5                   10                  15      


Ser Ala Leu Ala Asp Val Met Lys Lys Ala Ser Glu Leu Gln Lys Lys 
            20                  25                  30          


Gly Val Lys Leu Ile Ser Leu Ala Ala Gly Asp Pro Asp Pro Glu Leu 
        35                  40                  45              


Ile Pro Arg Ala Val Leu Gly Glu Ile Ala Lys Glu Val Leu Glu Lys 
    50                  55                  60                  


Glu Pro Lys Ser Val Met Tyr Thr Pro Ala Asn Gly Ile Pro Glu Leu 
65                  70                  75                  80  


Arg Glu Glu Leu Ala Ala Phe Leu Lys Lys Tyr Asp His Leu Glu Val 
                85                  90                  95      


Ser Pro Glu Asn Ile Val Ile Thr Ile Gly Gly Thr Gly Ala Leu Asp 
            100                 105                 110         


Leu Leu Gly Arg Val Leu Ile Asp Pro Gly Asp Val Val Ile Thr Glu 
        115                 120                 125             


Asn Pro Ser Tyr Ile Asn Thr Leu Leu Ala Phe Glu Gln Leu Gly Ala 
    130                 135                 140                 


Lys Ile Glu Gly Val Pro Val Asp Asn Asp Gly Met Arg Val Asp Leu 
145                 150                 155                 160 


Leu Glu Glu Lys Ile Lys Glu Leu Lys Ala Lys Gly Gln Lys Val Lys 
                165                 170                 175     


Leu Ile Tyr Thr Ile Pro Thr Gly Gln Asn Pro Met Gly Val Thr Met 
            180                 185                 190         


Ser Met Glu Arg Arg Lys Ala Leu Leu Glu Ile Ala Ser Lys Tyr Asp 
        195                 200                 205             


Leu Leu Ile Ile Glu Asp Thr Ala Tyr Asn Phe Met Arg Tyr Glu Gly 
    210                 215                 220                 


Gly Asp Ile Val Pro Leu Lys Ala Leu Asp Asn Glu Gly Arg Val Ile 
225                 230                 235                 240 


Val Ala Gly Thr Leu Ser Lys Val Leu Gly Thr Gly Phe Arg Ile Gly 
                245                 250                 255     


Trp Ile Ile Ala Glu Gly Glu Ile Leu Lys Lys Val Leu Met Gln Lys 
            260                 265                 270         


Gln Pro Ile Asp Phe Cys Ala Pro Ala Ile Ser Gln Tyr Ile Ala Leu 
        275                 280                 285             


Glu Tyr Leu Lys Arg Gly Tyr Phe Glu Lys Tyr His Leu Glu Gly Ala 
    290                 295                 300                 


Leu Leu Gly Tyr Lys Glu Lys Arg Asp Ile Met Leu Lys Ala Leu Glu 
305                 310                 315                 320 


Asn His Leu Pro Asn Ala Glu Phe Thr Lys Pro Ile Ala Gly Met Phe 
                325                 330                 335     


Val Met Phe Phe Leu Pro Glu Gly Ala Asp Gly Ile Ser Phe Ala Asn 
            340                 345                 350         


Glu Leu Met Glu Arg Glu Gly Val Val Val Val Pro Gly Lys Pro Phe 
        355                 360                 365             


Tyr Thr Asp Glu Ser Gly Lys Asn Ala Ile Arg Leu Asn Phe Ser Arg 
    370                 375                 380                 


Pro Ser Lys Glu Glu Ile Pro Ile Gly Ile Lys Lys Leu Ala Lys Leu 
385                 390                 395                 400 


Tyr Lys Glu Lys Phe Gly Glu 
                405         


<210>  9
<211>  1338
<212>  DNA
<213>  synthetic DNA

<400>  9
ggtctcccaa gcttgcatgc ctgcaggtcg actctagagg atccgacgtc aggaaaggag       60

aggattgatg gactatacca aatatcttgc gggccgggct aattggatta agggctctgc      120

actcgcggac gtaatgaaaa aagcatccga attgcagaaa aagggcgtca aacttatttc      180

gctcgccgcc ggtgatcctg accccgaact gattccccgt gcagtgttgg gcgagattgc      240

aaaggaggtc ctcgaaaaag aacctaagtc ggtaatgtac actcccgcca acggcattcc      300

ggagcttcgg gaggagttgg ccgcttttct caagaagtat gaccaccttg aagtgtctcc      360

tgagaacatc gtcatcacca ttggcggtac tggtgcactc gatctgcttg gacgtgtact      420

gatcgatcct ggcgacgtag tcatcacgga aaatccatcg tacattaaca ccctcctcgc      480

tttcgaacaa ctcggagcaa aaattgaggg agtaccggtg gataacgacg gcatgcgggt      540

tgaccttctg gaagagaaga tcaaagagtt gaaggctaag ggtcaaaaag tgaaactgat      600

ttatacgatt ccaaccggac aaaatccaat gggtgtaacg atgtcaatgg aacggcgtaa      660

ggcgttgctg gagatcgcct caaaatacga tttgctgatc attgaggaca ctgcgtacaa      720

cttcatgcgg tacgaaggtg gtgatattgt cccgctcaag gcgttggata atgagggacg      780

tgtgatcgtg gccggaaccc tttcaaaggt actcggcact ggttttcgta ttggctggat      840

tatcgccgaa ggcgagattt tgaagaaggt tctcatgcag aaacaaccta tcgatttctg      900

cgcgcccgcg atttcgcagt atattgcgct cgaatatctg aagcgtggat acttcgagaa      960

gtaccacctt gagggtgcat tgttgggata taaggagaaa cgcgacatca tgctgaaggc     1020

ccttgagaat catctcccga acgcagaatt caccaagccc atcgcgggta tgttcgtcat     1080

gttcttcctg ccagaaggtg cggacggcat ctcctttgcg aacgagctca tggagcgcga     1140

gggcgtagtc gttgtccccg gaaaaccttt ctacactgac gaatccggta aaaacgccat     1200

tcggctgaat ttctcccgcc cttcaaaaga agagattccc attggaatta aaaaacttgc     1260

taaactgtat aaagaaaaat tcggtgagta ataaggatcc ccgggtaccg agctcgaatt     1320

cactggccgt cggagacc                                                   1338


<210>  10
<211>  1146
<212>  DNA
<213>  Moorea producens


<220>
<221>  CDS
<222>  (1)..(1143)

<400>  10
atg tcg gaa aaa att gtt aat tcc tgg aat gaa tgg gat gaa ttg gaa         48
Met Ser Glu Lys Ile Val Asn Ser Trp Asn Glu Trp Asp Glu Leu Glu           
1               5                   10                  15                

gaa atg gtg gta gga att gca gac tat gct agc ttt gaa cca aaa gaa         96
Glu Met Val Val Gly Ile Ala Asp Tyr Ala Ser Phe Glu Pro Lys Glu           
            20                  25                  30                    

cca ggg aat cat ccg aaa tta aga aat caa aat tta gcg gaa atc att        144
Pro Gly Asn His Pro Lys Leu Arg Asn Gln Asn Leu Ala Glu Ile Ile           
        35                  40                  45                        

cct ttc ccc agt gga cct aaa gac cct aaa gtc ctt gaa aaa gct aat        192
Pro Phe Pro Ser Gly Pro Lys Asp Pro Lys Val Leu Glu Lys Ala Asn           
    50                  55                  60                            

gaa gaa tta aat gga ctg gct tat tta tta aaa gac cac gat gtg ata        240
Glu Glu Leu Asn Gly Leu Ala Tyr Leu Leu Lys Asp His Asp Val Ile           
65                  70                  75                  80            

gta aga aga ccc gaa aaa att gat ttt act aaa tct cta aaa aca cct        288
Val Arg Arg Pro Glu Lys Ile Asp Phe Thr Lys Ser Leu Lys Thr Pro           
                85                  90                  95                

tac ttt gaa gtt gca aat caa tac tgt gga gtc tgt cct cgg gat gtc        336
Tyr Phe Glu Val Ala Asn Gln Tyr Cys Gly Val Cys Pro Arg Asp Val           
            100                 105                 110                   

atg att acc ttt ggg aat gaa atc atg gaa gcg act atg tcg aag aga        384
Met Ile Thr Phe Gly Asn Glu Ile Met Glu Ala Thr Met Ser Lys Arg           
        115                 120                 125                       

gct aga ttt ttt gaa tac tta cct tac cgg aaa ttg gtc tat gaa tat        432
Ala Arg Phe Phe Glu Tyr Leu Pro Tyr Arg Lys Leu Val Tyr Glu Tyr           
    130                 135                 140                           

tgg aat aaa gac gag cat atg att tgg aat gct gcg cct aaa ccg act        480
Trp Asn Lys Asp Glu His Met Ile Trp Asn Ala Ala Pro Lys Pro Thr           
145                 150                 155                 160           

atg cag gat agt atg tat cta gag aat ttc tgg gag ctg tct tta gaa        528
Met Gln Asp Ser Met Tyr Leu Glu Asn Phe Trp Glu Leu Ser Leu Glu           
                165                 170                 175               

gaa cga ttt aag cgt atg cat gat ttt gaa ttt tgt att aca caa gat        576
Glu Arg Phe Lys Arg Met His Asp Phe Glu Phe Cys Ile Thr Gln Asp           
            180                 185                 190                   

gaa gta att ttt gat gcg gct gac tgt agc aga tta gga aag gat ata        624
Glu Val Ile Phe Asp Ala Ala Asp Cys Ser Arg Leu Gly Lys Asp Ile           
        195                 200                 205                       

tta gtt cag gaa tcg atg aca aca aat aga aca gga att cgg tgg tta        672
Leu Val Gln Glu Ser Met Thr Thr Asn Arg Thr Gly Ile Arg Trp Leu           
    210                 215                 220                           

aaa aag cac cta gaa cca aga gga ttt cgg gtt cac cct gtt cat ttt        720
Lys Lys His Leu Glu Pro Arg Gly Phe Arg Val His Pro Val His Phe           
225                 230                 235                 240           

ccc ctt gat ttt ttc ccc tca cac att gac tgt acg ttt gtt cct ttg        768
Pro Leu Asp Phe Phe Pro Ser His Ile Asp Cys Thr Phe Val Pro Leu           
                245                 250                 255               

cga cca ggt ctt att ttg aca aac cct gaa aga cct ata cgg gaa gag        816
Arg Pro Gly Leu Ile Leu Thr Asn Pro Glu Arg Pro Ile Arg Glu Glu           
            260                 265                 270                   

gag gag aag att ttt aaa gag aat ggc tgg gag ttg atc aca gtt cct        864
Glu Glu Lys Ile Phe Lys Glu Asn Gly Trp Glu Leu Ile Thr Val Pro           
        275                 280                 285                       

caa ccg act tgc tcg aat gat gaa atg cca atg ttt tgc cag tcc agt        912
Gln Pro Thr Cys Ser Asn Asp Glu Met Pro Met Phe Cys Gln Ser Ser           
    290                 295                 300                           

aag tgg ttg tca atg aat gtt ctg agt ata tca ccg aca aag gtt atc        960
Lys Trp Leu Ser Met Asn Val Leu Ser Ile Ser Pro Thr Lys Val Ile           
305                 310                 315                 320           

tgt gag gaa aga gaa aaa cct ctc caa gaa ttg ttg gat aag cat gga       1008
Cys Glu Glu Arg Glu Lys Pro Leu Gln Glu Leu Leu Asp Lys His Gly           
                325                 330                 335               

ttt gag gtt ttt cct tta ccc ttt aga cat gtc ttt gaa ttt ggg ggg       1056
Phe Glu Val Phe Pro Leu Pro Phe Arg His Val Phe Glu Phe Gly Gly           
            340                 345                 350                   

tct ttt cat tgt gca act tgg gat att cgc cga aaa ggt gag tgt gaa       1104
Ser Phe His Cys Ala Thr Trp Asp Ile Arg Arg Lys Gly Glu Cys Glu           
        355                 360                 365                       

gat tat tta cca aat tta aac tat caa ccg att tgt ggt taa               1146
Asp Tyr Leu Pro Asn Leu Asn Tyr Gln Pro Ile Cys Gly                       
    370                 375                 380                           


<210>  11
<211>  381
<212>  PRT
<213>  Moorea producens

<400>  11

Met Ser Glu Lys Ile Val Asn Ser Trp Asn Glu Trp Asp Glu Leu Glu 
1               5                   10                  15      


Glu Met Val Val Gly Ile Ala Asp Tyr Ala Ser Phe Glu Pro Lys Glu 
            20                  25                  30          


Pro Gly Asn His Pro Lys Leu Arg Asn Gln Asn Leu Ala Glu Ile Ile 
        35                  40                  45              


Pro Phe Pro Ser Gly Pro Lys Asp Pro Lys Val Leu Glu Lys Ala Asn 
    50                  55                  60                  


Glu Glu Leu Asn Gly Leu Ala Tyr Leu Leu Lys Asp His Asp Val Ile 
65                  70                  75                  80  


Val Arg Arg Pro Glu Lys Ile Asp Phe Thr Lys Ser Leu Lys Thr Pro 
                85                  90                  95      


Tyr Phe Glu Val Ala Asn Gln Tyr Cys Gly Val Cys Pro Arg Asp Val 
            100                 105                 110         


Met Ile Thr Phe Gly Asn Glu Ile Met Glu Ala Thr Met Ser Lys Arg 
        115                 120                 125             


Ala Arg Phe Phe Glu Tyr Leu Pro Tyr Arg Lys Leu Val Tyr Glu Tyr 
    130                 135                 140                 


Trp Asn Lys Asp Glu His Met Ile Trp Asn Ala Ala Pro Lys Pro Thr 
145                 150                 155                 160 


Met Gln Asp Ser Met Tyr Leu Glu Asn Phe Trp Glu Leu Ser Leu Glu 
                165                 170                 175     


Glu Arg Phe Lys Arg Met His Asp Phe Glu Phe Cys Ile Thr Gln Asp 
            180                 185                 190         


Glu Val Ile Phe Asp Ala Ala Asp Cys Ser Arg Leu Gly Lys Asp Ile 
        195                 200                 205             


Leu Val Gln Glu Ser Met Thr Thr Asn Arg Thr Gly Ile Arg Trp Leu 
    210                 215                 220                 


Lys Lys His Leu Glu Pro Arg Gly Phe Arg Val His Pro Val His Phe 
225                 230                 235                 240 


Pro Leu Asp Phe Phe Pro Ser His Ile Asp Cys Thr Phe Val Pro Leu 
                245                 250                 255     


Arg Pro Gly Leu Ile Leu Thr Asn Pro Glu Arg Pro Ile Arg Glu Glu 
            260                 265                 270         


Glu Glu Lys Ile Phe Lys Glu Asn Gly Trp Glu Leu Ile Thr Val Pro 
        275                 280                 285             


Gln Pro Thr Cys Ser Asn Asp Glu Met Pro Met Phe Cys Gln Ser Ser 
    290                 295                 300                 


Lys Trp Leu Ser Met Asn Val Leu Ser Ile Ser Pro Thr Lys Val Ile 
305                 310                 315                 320 


Cys Glu Glu Arg Glu Lys Pro Leu Gln Glu Leu Leu Asp Lys His Gly 
                325                 330                 335     


Phe Glu Val Phe Pro Leu Pro Phe Arg His Val Phe Glu Phe Gly Gly 
            340                 345                 350         


Ser Phe His Cys Ala Thr Trp Asp Ile Arg Arg Lys Gly Glu Cys Glu 
        355                 360                 365             


Asp Tyr Leu Pro Asn Leu Asn Tyr Gln Pro Ile Cys Gly 
    370                 375                 380     


<210>  12
<211>  1248
<212>  DNA
<213>  synthetic DNA

<400>  12
cgtctctgtg gataactgag cggataagtt cctagtacgc gtgcgagcag gaagaacatg       60

agcgagaaaa ttgtgaacag ctggaatgaa tgggatgaac tggaagaaat ggttgttggt      120

attgcagatt atgcaagctt tgaaccgaaa gaaccgggta atcatccgaa actgcgtaat      180

cagaatctgg cagaaattat tccgtttccg agcggtccga aagatccgaa agttctggaa      240

aaagcaaatg aagaactgaa tggtctggcc tatctgctga aagatcatga tgttattgtt      300

cgccgtccgg aaaaaatcga ctttaccaaa agcctgaaaa ccccgtattt cgaagttgcc      360

aatcagtatt gtggtgtttg tccgcgtgat gttatgatta cctttggcaa cgaaattatg      420

gaagccacca tgagcaaacg tgcccgtttt tttgaatatc tgccgtatcg taaactggtg      480

tatgagtatt ggaacaaaga tgagcatatg atctggaatg cagcaccgaa accgaccatg      540

caggatagca tgtatctgga aaacttttgg gaactgagcc tggaagaacg ttttaaacgt      600

atgcacgatt ttgagttttg catcacccag gatgaagtga tttttgatgc agcagattgt      660

agccgtctgg gtaaagatat tctggttcaa gaaagcatga ccaccaatcg taccggtatt      720

cgttggctga aaaaacatct ggaaccgcgt ggttttcgtg ttcatccggt tcattttccg      780

ctggattttt ttccgagcca tattgattgt acctttgttc cgctgcgtcc gggtctgatt      840

ctgaccaatc cggaacgtcc gattcgtgaa gaagaagaga aaatcttcaa agagaatggc      900

tgggagctga ttaccgttcc gcagccgacc tgtagcaatg atgaaatgcc gatgttttgt      960

cagagcagca aatggctgag catgaatgtt ctgagcatta gcccgaccaa agttatttgt     1020

gaagaacgtg aaaaaccgct gcaagaactg ctggataaac atggttttga agtgtttccg     1080

ctgccgtttc gtcatgtttt tgaatttggt ggtagctttc attgtgccac ctgggatatt     1140

cgtcgtaaag gtgaatgtga agattatctg ccgaatctga attatcagcc gatttgtggt     1200

taataagacg tccgcgaggg ccgtgttgcc ggtttcttca gagagacg                  1248


<210>  13
<211>  46
<212>  DNA
<213>  synthetic oligonucleotide

<400>  13
ggaaacagct atgacatgat tacgcggtta tcgcggaatc cgtatg                      46


<210>  14
<211>  25
<212>  DNA
<213>  synthetic oligonucleotide

<400>  14
ttaagcgttt tgtgcaactc cgtct                                             25


<210>  15
<211>  50
<212>  DNA
<213>  synthetic oligonucleotide

<400>  15
agacggagtt gcacaaaacg cttaaaccct acttagctgc caattattcc                  50


<210>  16
<211>  50
<212>  DNA
<213>  synthetic oligonucleotide

<400>  16
ggtaggtggt ggtgtcttta ctcatgggta aaaaatcctt tcgtaggttt                  50


<210>  17
<211>  25
<212>  DNA
<213>  synthetic oligonucleotide

<400>  17
atgagtaaag acaccaccac ctacc                                             25


<210>  18
<211>  46
<212>  DNA
<213>  synthetic oligonucleotide

<400>  18
gttgtaaaac gacggccagt gccaccggtg atgtggttct tcactg                      46


<210>  19
<211>  51
<212>  DNA
<213>  synthetic oligonucleotide

<400>  19
gaattcgagc tcggtacccg gggatcctct ttcatacctt aacgcagtag t                51


<210>  20
<211>  37
<212>  DNA
<213>  synthetic oligonucleotide

<400>  20
gcgttgacgc gggctcgagc agtggtcgtc gacaagc                                37


<210>  21
<211>  37
<212>  DNA
<213>  synthetic oligonucleotide

<400>  21
cgacgaccac tgctcgagcc cgcgtcaacg cgttcgg                                37


<210>  22
<211>  48
<212>  DNA
<213>  synthetic oligonucleotide

<400>  22
caagcttgca tgcctgcagg tcgactttgg aacggagttc gctgggta                    48


<210>  23
<211>  17
<212>  DNA
<213>  synthetic oligonucleotide


<220>
<221>  RBS
<222>  (1)..(17)
<223>  Shi F, Luan M, Li Y, AMB Express. 2018 Apr 18;8(1):61. doi: 
       10.1186/s13568-018-0595-2

<400>  23
aggaaaggag aggattg                                                      17


201900349A	3


