序列表

<110>  上海济煜医药科技有限公司；江西济民可信集团有限公司

<120>  一种抗IgE的工程化抗体及其应用

<130>  0134-PA-015

<160>  64

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LFR1

<400>  1

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  2
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  2

Arg Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  3

Arg Ala Ser Gln Ser Val Asp Tyr Glu Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  4

Arg Ala Ser Gln Ser Leu Tyr Asp Glu Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  5

Arg Ala Ser Gln Ser Val Ala Asp Glu Trp Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  6

Arg Ala Ser Gln Ser Val Asp Ala Glu Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  7

Arg Ala Ser Gln Ser Val Asp Asp Glu Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  8

Arg Ala Ser Gln Ser Val Asp Asp Glu Tyr Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  9

Arg Ala Ser Gln Ser Val Asp Ser Glu Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  10

Arg Ala Ser Gln Ser Val Glu Asp Glu Trp Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  11

Arg Ala Ser Gln Ser Val Phe Asp Glu Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  12

Arg Ala Ser Gln Ser Val Gly Asp Glu Ala Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  13

Arg Ala Ser Gln Ser Val Asn Asp Glu Ala Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  14

Arg Ala Ser Gln Ser Val Asn Asp Glu Trp Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LFR2

<400>  15

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  16
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR2

<400>  16

Ala Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR2

<400>  17

Ala Ala Ser Tyr Leu Gln Ser 
1               5           


<210>  18
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LFR3

<400>  18

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  19
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR3

<400>  19

Gln Gln Ser His Glu Asp Pro Tyr Thr 
1               5                   


<210>  20
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LFR4

<400>  20

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LFR4

<400>  21

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  22
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  22

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  23
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  23

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Tyr Glu 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  24
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  24

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Leu Tyr Asp Glu 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  25
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  25

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ala Asp Glu 
            20                  25                  30          


Trp Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  26
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  26

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Ala Glu 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  27
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  27

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Asp Glu 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  28
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  28

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Asp Glu 
            20                  25                  30          


Tyr Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  29
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  29

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Ser Glu 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  30
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  30

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Glu Asp Glu 
            20                  25                  30          


Trp Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  31
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  31

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Phe Asp Glu 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  32
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  32

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Gly Asp Glu 
            20                  25                  30          


Ala Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  33
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  33

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asn Asp Glu 
            20                  25                  30          


Ala Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  34
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<400>  34

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asn Asp Glu 
            20                  25                  30          


Trp Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  35
<211>  25
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HFR1

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser 
            20                  25  


<210>  36
<211>  8
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR1

<400>  36

Gly Tyr Ser Ile Thr Ser Gly Tyr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR1

<400>  37

Gly Tyr Ser Ile Arg Ser Gly Tyr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR1

<400>  38

Gly Tyr Ser Ile Thr Gln Gly Tyr 
1               5               


<210>  39
<211>  19
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HFR2

<400>  39

Ser Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Ser Ile 
            


<210>  40
<211>  19
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HFR2

<400>  40

Ser Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ser Val Ile 
            


<210>  41
<211>  5
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR2

<400>  41

Thr Tyr Asp Gly Ser 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR2

<400>  42

Thr Tyr Ala Gly Ser 
1               5   


<210>  43
<211>  41
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HFR3

<400>  43

Thr Asn Tyr Asn Pro Ser Val Lys Gly Arg Ile Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ser Lys Asn Thr Phe Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  44
<211>  41
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HFR3

<400>  44

Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ser Lys Asn Thr Phe Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  45
<211>  12
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR3

<400>  45

Gly Ser His Tyr Phe Gly His Trp His Phe Ala Val 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR3

<400>  46

Gly Thr Asn Tyr Phe Gly His Trp His Phe Ala Val 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR3

<400>  47

Gly Thr His Tyr Phe Gly His Trp His Phe Ala Val 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR3

<400>  48

Gly Ser Asn Tyr Phe Gly His Trp His Phe Ala Val 
1               5                   10          


<210>  49
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HFR4

<400>  49

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  50
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VH

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Ser Ile Thr Tyr Asp Gly Ser Thr Asn Tyr Asn Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Ile Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  51
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VH

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Val Ile Thr Tyr Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  52
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VH

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Val Ile Thr Tyr Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Asn Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  53
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VH

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Arg Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Val Ile Thr Tyr Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  54
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VH

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Val Ile Thr Tyr Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr His Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  55
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VH

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Val Ile Thr Tyr Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asn Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  56
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VH

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Thr Gln Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Val Ile Thr Tyr Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  57
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VL

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = Ala、Asp、Glu、Phe、Gly、Asn或Tyr

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = Ala、Asp、Ser或Tyr

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = Ala、Gly、Trp或Tyr

<400>  57

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Xaa Xaa Xaa Glu 
            20                  25                  30          


Xaa Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  58
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  VH

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = Arg或Thr

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = Gln或Ser

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa = His或Asn

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Xaa Xaa Gly 
            20                  25                  30          


Tyr Ser Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Val Ile Thr Tyr Ala Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Xaa Xaa Tyr Phe Gly His Trp His Phe Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  轻链恒定区

<400>  59

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  60
<211>  330
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  IgG1恒定区（无突变）

<400>  60

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  61
<211>  330
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  IgG1恒定区（YTE突变）

<400>  61

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  62
<211>  8
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR1通式

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Arg或Thr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Gln或Ser

<400>  62

Gly Tyr Ser Ile Xaa Xaa Gly Tyr 
1               5               


<210>  63
<211>  12
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR3通式

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = His或Asn

<400>  63

Gly Xaa Xaa Tyr Phe Gly His Trp His Phe Ala Val 
1               5                   10          


<210>  64
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1通式

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Ala、Asp、Glu、Phe、Gly、Asn或Tyr

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Ala、Asp、Ser或Tyr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Ala、Gly、Trp或Tyr

<400>  64

Arg Ala Ser Gln Ser Xaa Xaa Xaa Glu Xaa Asp Ser Tyr Met Asn 
1               5                   10                  15  

