                         SEQUENCE LISTING

<110>  йѧԺоϸҽѧоԺ
 
<120>  һֱ༭ϵͳ

<130>  IEC200267PCT

<150>  202010663076.8
<151>  2020-07-10

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  1368
<212>  PRT
<213>  artificial

<220>
<223>  Cas9

<400>  1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  2
<211>  236
<212>  PRT
<213>  artificial

<220>
<223>  mCherry

<400>  2

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  3
<211>  76
<212>  DNA
<213>  artificial

<220>
<223>  ȱеgRNA

<400>  3
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgc                                                       76


<210>  4
<211>  722
<212>  PRT
<213>  artificial

<220>
<223>  MLV RT

<400>  4

Met Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
1               5                   10                  15      


Gly Gly Ser Ser Gly Gly Ser Ser Thr Leu Asn Ile Glu Asp Glu Tyr 
            20                  25                  30          


Arg Leu His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr 
        35                  40                  45              


Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly 
    50                  55                  60                  


Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser 
65                  70                  75                  80  


Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu 
                85                  90                  95      


Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val 
            100                 105                 110         


Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro 
        115                 120                 125             


Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys 
    130                 135                 140                 


Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu 
145                 150                 155                 160 


Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys 
                165                 170                 175     


Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe 
            180                 185                 190         


Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr 
        195                 200                 205             


Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn 
    210                 215                 220                 


Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp 
225                 230                 235                 240 


Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser 
                245                 250                 255     


Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly 
            260                 265                 270         


Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys 
        275                 280                 285             


Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu 
    290                 295                 300                 


Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr 
305                 310                 315                 320 


Pro Arg Gln Leu Arg Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu 
                325                 330                 335     


Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr 
            340                 345                 350         


Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr 
        355                 360                 365             


Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro 
    370                 375                 380                 


Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr 
385                 390                 395                 400 


Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val 
                405                 410                 415     


Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro 
            420                 425                 430         


Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly 
        435                 440                 445             


Lys Leu Thr Met Gly Gln Pro Leu Val Ile Leu Ala Pro His Ala Val 
    450                 455                 460                 


Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg 
465                 470                 475                 480 


Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe 
                485                 490                 495     


Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu 
            500                 505                 510         


Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly 
        515                 520                 525             


Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr 
    530                 535                 540                 


Trp Tyr Thr Asp Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala 
545                 550                 555                 560 


Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu 
                565                 570                 575     


Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln 
            580                 585                 590         


Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser 
        595                 600                 605             


Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg 
    610                 615                 620                 


Arg Gly Trp Leu Thr Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu 
625                 630                 635                 640 


Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile 
                645                 650                 655     


Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala Arg Gly 
            660                 665                 670         


Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr 
        675                 680                 685             


Pro Asp Thr Ser Thr Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly 
    690                 695                 700                 


Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg 
705                 710                 715                 720 


Lys Val 
        


<210>  5
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-gRNA-F

<400>  5
ccggagagag agaccctcac tgct                                              24


<210>  6
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-gRNA-R

<400>  6
aaacagcagt gagggtctct ctct                                              24


<210>  7
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-gRNA

<400>  7
agagagagac cctcactgct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  8
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Actb-gRNA-F

<400>  8
ccggatcccc caaagttcac aatg                                              24


<210>  9
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Actb-gRNA-R

<400>  9
aaaccattgt gaactttggg ggat                                              24


<210>  10
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  Actb-gRNA

<400>  10
atcccccaaa gttcacaatg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  11
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-gRNA-F

<400>  11
ccggtagcgt tgacccgacc ccaa                                              24


<210>  12
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-gRNA-R

<400>  12
aaacttgggg tcgggtcaac gcta                                              24


<210>  13
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-gRNA

<400>  13
tagcgttgac ccgaccccaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  14
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-gRNA-F

<400>  14
ccgggtaagc acacgtgcaa agtg                                              24


<210>  15
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-gRNA-R

<400>  15
aaaccacttt gcacgtgtgc ttac                                              24


<210>  16
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-gRNA

<400>  16
gtaagcacac gtgcaaagtg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  17
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  spacerA-gRNA-F

<400>  17
ccgggagatc gagtgccgca tcac                                              24


<210>  18
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  spacerA-gRNA-R

<400>  18
aaacgtgatg cggcactcga tctc                                              24


<210>  19
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  spacerA-gRNA

<400>  19
gagatcgagt gccgcatcac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  20
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  spacerK-gRNA-F

<400>  20
ccgggtcgcc ctcgaacttc acct                                              24


<210>  21
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  spacerK-gRNA-R

<400>  21
aaacaggtga agttcgaggg cgac                                              24


<210>  22
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  spacerK-gRNA

<400>  22
gtcgccctcg aacttcacct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  23
<211>  65
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-pegA-F

<400>  23
aaagtggcac cgagtcggtg cagcaagagc acaagaggaa gagagagacc ctcactatgc       60

ggcac                                                                   65


<210>  24
<211>  62
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-pegA-R

<400>  24
acagctatga ccatgattac gccaagctta aaaaaaatcg agtgccgcat agtgagggtc       60

tc                                                                      62


<210>  25
<211>  144
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-pegA

<400>  25
gagatcgagt gccgcatcac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcagca agagcacaag aggaagagag      120

agaccctcac tatgcggcac tcga                                             144


<210>  26
<211>  56
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-pegK-F

<400>  26
aaagtggcac cgagtcggtg ctggtggggg actgagtgtg gcagggactc cccagc           56


<210>  27
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-pegK-R

<400>  27
gaccatgatt acgccaagct taaaaaaaac cctcgaactt cagctgggga gtccctgcca       60


<210>  28
<211>  144
<212>  DNA
<213>  artificial

<220>
<223>  Gapdh-pegK

<400>  28
gtcgccctcg aacttcacct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctggt gggggactga gtgtggcagg      120

gactccccag ctgaagttcg aggg                                             144


<210>  29
<211>  62
<212>  DNA
<213>  artificial

<220>
<223>  Actb-pegA-F

<400>  29
aaagtggcac cgagtcggtg ccagtcggtt ggagcgagca tcccccaaag ttcacaatgc       60

gg                                                                      62


<210>  30
<211>  66
<212>  DNA
<213>  artificial

<220>
<223>  Actb-pegA-R

<400>  30
acagctatga ccatgattac gccaagctta aaaaaaatcg agtgccgcat tgtgaacttt       60

ggggga                                                                  66


<210>  31
<211>  144
<212>  DNA
<213>  artificial

<220>
<223>  Actb-pegA

<400>  31
gagatcgagt gccgcatcac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgccagt cggttggagc gagcatcccc      120

caaagttcac aatgcggcac tcga                                             144


<210>  32
<211>  66
<212>  DNA
<213>  artificial

<220>
<223>  Actb-pegK-F

<400>  32
aaagtggcac cgagtcggtg caaacaacaa tgtgcaatca aagtcctcgg ccacattgaa       60

gttcga                                                                  66


<210>  33
<211>  63
<212>  DNA
<213>  artificial

<220>
<223>  Actb-pegK-R

<400>  33
acagctatga ccatgattac gccaagctta aaaaaaaccc tcgaacttca atgtggccga       60

gga                                                                     63


<210>  34
<211>  144
<212>  DNA
<213>  artificial

<220>
<223>  Actb-pegK

<400>  34
gtcgccctcg aacttcacct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcaaac aacaatgtgc aatcaaagtc      120

ctcggccaca ttgaagttcg aggg                                             144


<210>  35
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-pegRNA-F

<400>  35
aagtggcacc gagtcggtgc tttacagcct ggcctttgga gatcgagtgc cgcatgggtc       60


<210>  36
<211>  65
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-pegRNA-R

<400>  36
aacagctatg accatgatta cgccaagctt aaaaaaaatt gacccgaccc atgcggcact       60

cgatc                                                                   65


<210>  37
<211>  143
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-pegRNA

<400>  37
tagcgttgac ccgaccccaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcttta cagcctggcc tttggagatc      120

gagtgccgca tgggtcgggt caa                                              143


<210>  38
<211>  61
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-pegRNA-F

<400>  38
aagtggcacc gagtcggtgc gttactcccg ggcctcacgt cgccctcgaa cttcatttgc       60

a                                                                       61


<210>  39
<211>  68
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-pegRNA-R

<400>  39
aacagctatg accatgatta cgccaagctt aaaaaaaagc acacgtgcaa atgaagttcg       60

agggcgac                                                                68


<210>  40
<211>  144
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-pegRNA

<400>  40
gtaagcacac gtgcaaagtg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcgtta ctcccgggcc tcacgtcgcc      120

ctcgaacttc atttgcacgt gtgc                                             144


<210>  41
<211>  59
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-pegA-F

<400>  41
aagtggcacc gagtcggtgc gcccttcccc tgccagccta gcgttgaccc gacccatgc        59


<210>  42
<211>  67
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-pegA-R

<400>  42
acagctatga ccatgattac gccaagctta aaaaaaatcg agtgccgcat gggtcgggtc       60

aacgcta                                                                 67


<210>  43
<211>  144
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRC-pegA

<400>  43
gagatcgagt gccgcatcac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcgccc ttcccctgcc agcctagcgt      120

tgacccgacc catgcggcac tcga                                             144


<210>  44
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-pegK-F

<400>  44
aagtggcacc gagtcggtgc tacttttgtc tccactaggt aagcacacgt gcaaatgaag       60


<210>  45
<211>  71
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-pegK-R

<400>  45
aacagctatg accatgatta cgccaagctt aaaaaaaacc ctcgaacttc atttgcacgt       60

gtgcttacct a                                                            71


<210>  46
<211>  144
<212>  DNA
<213>  artificial

<220>
<223>  GapdhRT-pegK

<400>  46
gtcgccctcg aacttcacct gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctact tttgtctcca ctaggtaagc      120

acacgtgcaa atgaagttcg aggg                                             144


<210>  47
<211>  1447
<212>  DNA
<213>  artificial

<220>
<223>  IRES-EGFP

<400>  47
ccggtgatgc ggcactcgat ctcgaattcc ccctctccct cccccccccc taacgttact       60

ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt ttccaccata      120

ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt      180

cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa      240

gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag      300

cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt ataagataca      360

cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc      420

aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat      480

tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta      540

aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga      600

taatatggcc acaacgctcg gtttaaaaag cttctatgcc tgaataggtg accggaggtc      660

ggcacctttc ctttgcaatt actgacccta tgaatacagg atctatggtg agcaagggcg      720

aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc      780

acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga      840

agttcatctg cactacgggg aaactgcccg tgccctggcc caccctcgtg accaccctga      900

cctacggcgt gcagtgcttc agccgctacc ccgaccacat gaagcagcac gacttcttca      960

agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca     1020

actacaagac ccgcgctgaa gtcaaattcg agggcgacac cctggtgaac cgcatcgagc     1080

tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact     1140

acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact     1200

tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga     1260

acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agcacccagt     1320

ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga     1380

ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaagtcgcc ctcgaacttc     1440

acctcgg                                                               1447


<210>  48
<211>  4259
<212>  DNA
<213>  artificial

<220>
<223>  T2A-EGFPĻƬ

<400>  48
ccggtgatgc ggcactcgat ctccaaaggc caggctgtaa atgtcaccgg gaggattggg       60

tgtctgggcg cctcggggaa cctgcccttc tccccattcc gtcttccgga aaccagatct      120

cccaccgcac cctggtctga ggttaaatat agctgctgac ctttctgtag ctgggggcct      180

gggctggggc tctctcccat cccttctccc cacacacatg cacttacctg tgctcccact      240

cctgatttct ggaaaagagc taggaaggac aggcaacttg gcaaatcaaa gccctgggac      300

tagggggtta aaatacagct tcccctcttc ccacccgccc cagtctctgt cccttttgta      360

ggagggactt agagaagggg tgggcttgcc ctgtccagtt aatttctgac ctttactcct      420

gccctttgag tttgatgatg ctgagtgtac aagcgttttc tccctaaagg gtgcagctga      480

gctaggcagc agcaagcatt cctggggtgg catagtgggg tggtgaatac catgtacaaa      540

gcttgtgccc agactgtggg tggcagtgcc ccacatggcc gcttctcctg gaagggcttc      600

gtatgactgg gggtgttggg cagccctgga gccttcagtt gcagccatgc cttaagccag      660

gccagcctgg cagggaagct caagggagat aaaattcaac ctcttgggcc ctcctggggg      720

taaggagatg ctgcattcgc cctcttaatg gggaggtggc ctagggctgc tcacatattc      780

tggaggagcc tcccctcctc atgccttctt gcctcttgtc tcttagattt ggtcgtattg      840

ggcgcctggt caccagggct gcttttaact ctggtaaagt ggatattgtt gccatcaatg      900

accccttcat tgacctcaac tacatggtga gtgctacatg gtgagcccca aagctggtgt      960

gggaggagcc acctggctga tgggcagccc cttcataccc tcacgtattc ccccaggttt     1020

acatgttcca atatgattcc acccatggca aattccatgg caccgtcaag gctgagaacg     1080

ggaagcttgt catcaatgga aatcccatca ccatcttcca ggagtgagtg gaagacagaa     1140

tggaagaaat gtgctttggg gaggcaacta ggatggtgtg gctcccttgg gtatatggta     1200

accttgtgtc cctcaatatg gtcctgtccc catctccccc ccacccccat aggcgagatc     1260

cctccaaaat caagtggggc gatgctggcg ctgagtacgt cgtggagtcc actggcgtct     1320

tcaccaccat ggagaaggct ggggtgagtg caggagggcc cgcgggaggg gaagctgact     1380

cagccctgca aaggcaggac ccgggttcat aactgtctgc ttctctgctg taggctcatt     1440

tgcagggggg agccaaaagg gtcatcatct ctgccccctc tgctgatgcc cccatgttcg     1500

tcatgggtgt gaaccatgag aagtatgaca acagcctcaa gatcatcagg tgaggaaggc     1560

agggcccgtg gagaagcggc cagcctggca ccctatggac acgctcccct gacttgcgcc     1620

ccgctccctc tttctttgca gcaatgcctc ctgcaccacc aactgcttag cacccctggc     1680

caaggtcatc catgacaact ttggtatcgt ggaaggactc atggtatgag agctggggaa     1740

tgggactgag gctcccacct ttctcatcca agactggctc ctccctgccg gggctgcgtg     1800

caaccctggg gttgggggtt ctggggactg gctttcccat aatttccttt caaggtgggg     1860

agggaggtag aggggtgatg tggggagtac gctgcagggc ctcactcctt ttgcagacca     1920

cagtccatgc catcactgcc acccagaaga ctgtggatgg cccctccggg aaactgtggc     1980

gtgatggccg cggggctctc cagaacatca tccctgcctc tactggcgct gccaaggctg     2040

tgggcaaggt catccctgag ctgaacggga agctcactgg catggccttc cgtgtcccca     2100

ctgccaacgt gtcagtggtg gacctgacct gccgtctaga aaaacctgcc aaatatgatg     2160

acatcaagaa ggtggtgaag caggcgtcgg agggccccct caagggcatc ctgggctaca     2220

ctgagcacca ggtggtctcc tctgacttca acagcgacac ccactcctcc acctttgacg     2280

ctggggctgg cattgccctc aacgaccact ttgtcaagct catttcctgg tatgtggctg     2340

gggccagaga ctggctctta aaaagtgcag ggtctggcgc cctctggtgg ctggctcaga     2400

aaaagggccc tgacaactct tttcatcttc taggtatgac aacgaatttg gctacagcaa     2460

cagggtggtg gacctcatgg cccacatggc ctccaaggag gagggcagag gaagtcttct     2520

aacatgcggt gacgtggagg agaatcccgg cccaatggtg agcaagggcg aggagctgtt     2580

caccggggtg gtgcccatcc tggtcgaact cgatggagat gtgaacggcc acaagttcag     2640

cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg     2700

cactacgggg aaactgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt     2760

gcagtgcttc agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat     2820

gccagaggga tatgtgcaag agcgcaccat cttcttcaag gacgacggca actacaagac     2880

ccgcgctgaa gtcaaattcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat     2940

cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca     3000

caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg     3060

ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat     3120

cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag     3180

caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg     3240

gatcactctc ggcatggacg agctgtacaa gtaagacccc tggaccacca gccccagcaa     3300

gagcacaaga ggaagagaga gaccctcact gctggggagt ccctgccaca ctcagtcccc     3360

caccacactg aatctcccct cctcacagtt gccatgtaga ccccttgaag aggggagggg     3420

cctagggagc cgcaccttgt catgtaccat caataaagta ccctgtgctc aaccagttac     3480

ttgtcctgtc ttattctagg gtctggggca gaggggaggg aagctgggct tgtgtcaagg     3540

tgagacattc ttgctgggga gggacctggt atgttctcct cagactgagg gtagggcctc     3600

caaacagcct tgcttgcttc gagaaccatt tgcttcccgc tcagacgtct tgagtgctac     3660

aggaagctgg caccactact tcagagaaca aggccttttc ctctcctcgc tccagtccta     3720

ggctatctgc tgttggccaa acatggaaga agctattctg tgggcagccc cagggaggct     3780

gacaggtgga ggaagtcagg gctcgcactg ggctctgacg ctgactggtt agtggagctc     3840

agcctggagc tgagctgcag cgggcaattc cagcttggcc tccgcagctg tgaggtcttg     3900

agcacgtgct ctattgcttt ctgtgccctc gtgtcttatc tgaggacatc gtggccagcc     3960

cctaaggtct tcaagcagga ttcatctagg taaaccaagt acctaaaacc atgcccaagg     4020

cggtaaggac tatataatgt ttaaaaatcg gtaaaaatgc ccacctcgca tagttttgag     4080

gaagatgaac tgagatgtgt cagggtgact tatttccatc atcgtcctta ggggaacttg     4140

ggtaggggca aggcgtgtag ctgggaccta ggtccagacc cctggctctg ccactgaacg     4200

gctcagttgc tttgggcagt tactcccggg cctcacgtcg ccctcgaact tcacctcgg      4259


<210>  49
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  SpacerA

<400>  49
gagatcgagt gccgcatcac cgg                                               23


<210>  50
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  SpacerK

<400>  50
gtcgccctcg aacttcacct cgg                                               23


<210>  51
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  ͷ

<400>  51

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
1               5                   10  


<210>  52
<211>  2099
<212>  PRT
<213>  artificial

<220>
<223>  ںϵ

<400>  52

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Gly  Gly Ser Ser Gly Gly  Ser Ser Gly Ser Glu  Thr Pro Gly 
    1370                 1375                 1380             


Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Ser Gly Gly  Ser Ser Gly 
    1385                 1390                 1395             


Gly Ser  Ser Thr Leu Asn Ile  Glu Asp Glu Tyr Arg  Leu His Glu 
    1400                 1405                 1410             


Thr Ser  Lys Glu Pro Asp Val  Ser Leu Gly Ser Thr  Trp Leu Ser 
    1415                 1420                 1425             


Asp Phe  Pro Gln Ala Trp Ala  Glu Thr Gly Gly Met  Gly Leu Ala 
    1430                 1435                 1440             


Val Arg  Gln Ala Pro Leu Ile  Ile Pro Leu Lys Ala  Thr Ser Thr 
    1445                 1450                 1455             


Pro Val  Ser Ile Lys Gln Tyr  Pro Met Ser Gln Glu  Ala Arg Leu 
    1460                 1465                 1470             


Gly Ile  Lys Pro His Ile Gln  Arg Leu Leu Asp Gln  Gly Ile Leu 
    1475                 1480                 1485             


Val Pro  Cys Gln Ser Pro Trp  Asn Thr Pro Leu Leu  Pro Val Lys 
    1490                 1495                 1500             


Lys Pro  Gly Thr Asn Asp Tyr  Arg Pro Val Gln Asp  Leu Arg Glu 
    1505                 1510                 1515             


Val Asn  Lys Arg Val Glu Asp  Ile His Pro Thr Val  Pro Asn Pro 
    1520                 1525                 1530             


Tyr Asn  Leu Leu Ser Gly Leu  Pro Pro Ser His Gln  Trp Tyr Thr 
    1535                 1540                 1545             


Val Leu  Asp Leu Lys Asp Ala  Phe Phe Cys Leu Arg  Leu His Pro 
    1550                 1555                 1560             


Thr Ser  Gln Pro Leu Phe Ala  Phe Glu Trp Arg Asp  Pro Glu Met 
    1565                 1570                 1575             


Gly Ile  Ser Gly Gln Leu Thr  Trp Thr Arg Leu Pro  Gln Gly Phe 
    1580                 1585                 1590             


Lys Asn  Ser Pro Thr Leu Phe  Asn Glu Ala Leu His  Arg Asp Leu 
    1595                 1600                 1605             


Ala Asp  Phe Arg Ile Gln His  Pro Asp Leu Ile Leu  Leu Gln Tyr 
    1610                 1615                 1620             


Val Asp  Asp Leu Leu Leu Ala  Ala Thr Ser Glu Leu  Asp Cys Gln 
    1625                 1630                 1635             


Gln Gly  Thr Arg Ala Leu Leu  Gln Thr Leu Gly Asn  Leu Gly Tyr 
    1640                 1645                 1650             


Arg Ala  Ser Ala Lys Lys Ala  Gln Ile Cys Gln Lys  Gln Val Lys 
    1655                 1660                 1665             


Tyr Leu  Gly Tyr Leu Leu Lys  Glu Gly Gln Arg Trp  Leu Thr Glu 
    1670                 1675                 1680             


Ala Arg  Lys Glu Thr Val Met  Gly Gln Pro Thr Pro  Lys Thr Pro 
    1685                 1690                 1695             


Arg Gln  Leu Arg Glu Phe Leu  Gly Lys Ala Gly Phe  Cys Arg Leu 
    1700                 1705                 1710             


Phe Ile  Pro Gly Phe Ala Glu  Met Ala Ala Pro Leu  Tyr Pro Leu 
    1715                 1720                 1725             


Thr Lys  Pro Gly Thr Leu Phe  Asn Trp Gly Pro Asp  Gln Gln Lys 
    1730                 1735                 1740             


Ala Tyr  Gln Glu Ile Lys Gln  Ala Leu Leu Thr Ala  Pro Ala Leu 
    1745                 1750                 1755             


Gly Leu  Pro Asp Leu Thr Lys  Pro Phe Glu Leu Phe  Val Asp Glu 
    1760                 1765                 1770             


Lys Gln  Gly Tyr Ala Lys Gly  Val Leu Thr Gln Lys  Leu Gly Pro 
    1775                 1780                 1785             


Trp Arg  Arg Pro Val Ala Tyr  Leu Ser Lys Lys Leu  Asp Pro Val 
    1790                 1795                 1800             


Ala Ala  Gly Trp Pro Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala 
    1805                 1810                 1815             


Val Leu  Thr Lys Asp Ala Gly  Lys Leu Thr Met Gly  Gln Pro Leu 
    1820                 1825                 1830             


Val Ile  Leu Ala Pro His Ala  Val Glu Ala Leu Val  Lys Gln Pro 
    1835                 1840                 1845             


Pro Asp  Arg Trp Leu Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala 
    1850                 1855                 1860             


Leu Leu  Leu Asp Thr Asp Arg  Val Gln Phe Gly Pro  Val Val Ala 
    1865                 1870                 1875             


Leu Asn  Pro Ala Thr Leu Leu  Pro Leu Pro Glu Glu  Gly Leu Gln 
    1880                 1885                 1890             


His Asn  Cys Leu Asp Ile Leu  Ala Glu Ala His Gly  Thr Arg Pro 
    1895                 1900                 1905             


Asp Leu  Thr Asp Gln Pro Leu  Pro Asp Ala Asp His  Thr Trp Tyr 
    1910                 1915                 1920             


Thr Asp  Gly Ser Ser Leu Leu  Gln Glu Gly Gln Arg  Lys Ala Gly 
    1925                 1930                 1935             


Ala Ala  Val Thr Thr Glu Thr  Glu Val Ile Trp Ala  Lys Ala Leu 
    1940                 1945                 1950             


Pro Ala  Gly Thr Ser Ala Gln  Arg Ala Glu Leu Ile  Ala Leu Thr 
    1955                 1960                 1965             


Gln Ala  Leu Lys Met Ala Glu  Gly Lys Lys Leu Asn  Val Tyr Thr 
    1970                 1975                 1980             


Asp Ser  Arg Tyr Ala Phe Ala  Thr Ala His Ile His  Gly Glu Ile 
    1985                 1990                 1995             


Tyr Arg  Arg Arg Gly Trp Leu  Thr Ser Glu Gly Lys  Glu Ile Lys 
    2000                 2005                 2010             


Asn Lys  Asp Glu Ile Leu Ala  Leu Leu Lys Ala Leu  Phe Leu Pro 
    2015                 2020                 2025             


Lys Arg  Leu Ser Ile Ile His  Cys Pro Gly His Gln  Lys Gly His 
    2030                 2035                 2040             


Ser Ala  Glu Ala Arg Gly Asn  Arg Met Ala Asp Gln  Ala Ala Arg 
    2045                 2050                 2055             


Lys Ala  Ala Ile Thr Glu Thr  Pro Asp Thr Ser Thr  Leu Leu Ile 
    2060                 2065                 2070             


Glu Asn  Ser Ser Pro Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly 
    2075                 2080                 2085             


Ser Glu  Phe Glu Pro Lys Lys  Lys Arg Lys Val 
    2090                 2095                 


<210>  53
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  sgACTB2-F

<400>  53
ccggccaccg caaatgcttc tagg                                              24


<210>  54
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  sgACTB2-R

<400>  54
aaaccctaga agcatttgcg gtgg                                              24


<210>  55
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  sgACTB2

<400>  55
ccaccgcaaa tgcttctagg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  56
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-sgL-F

<400>  56
ccgggagctg gacggcgacg taaa                                              24


<210>  57
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-sgL-R

<400>  57
aaactttacg tcgccgtcca gctc                                              24


<210>  58
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-sgL

<400>  58
gagctggacg gcgacgtaaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  59
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-sgR-F

<400>  59
ccggcatgcc cgaaggctac gtcc                                              24


<210>  60
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-sgR-R

<400>  60
aaacggacgt agccttcggg catg                                              24


<210>  61
<211>  96
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-sgR

<400>  61
catgcccgaa ggctacgtcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  62
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-pegL-F

<400>  62
aaagtggcac cgagtcggtg cggcccctcc atcgtccacc gcaaatgctt cacgtcgccg       60


<210>  63
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-pegL-R

<400>  63
aacagctatg accatgatta cgccaagctt aaaaaaaaga cggcgacgtg aagcatttgc       60


<210>  64
<211>  137
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-pegL

<400>  64
gagctggacg gcgacgtaaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcggcc cctccatcgt ccaccgcaaa      120

tgcttcacgt cgccgtc                                                     137


<210>  65
<211>  58
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-pegR-F

<400>  65
aaagtggcac cgagtcggtg cggtgtaacg caactaagtc atagtccgcc tcgtagcc         58


<210>  66
<211>  63
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-pegR-R

<400>  66
aacagctatg accatgatta cgccaagctt aaaaaaaacg aaggctacga ggcggactat       60

gac                                                                     63


<210>  67
<211>  137
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-pegR

<400>  67
catgcccgaa ggctacgtcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcggtg taacgcaact aagtcatagt      120

ccgcctcgta gccttcg                                                     137


<210>  68
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  GAPDH-P1

<400>  68
aaaagtgcag ggtctggc                                                     18


<210>  69
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  GAPDH-P2

<400>  69
acaccggcct tattccaagc                                                   20


<210>  70
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  GAPDH-P3

<400>  70
ccgaccacta ccagcagaac ac                                                22


<210>  71
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  GAPDH-P4

<400>  71
ccagacccta gaataagaca ggaca                                             25


<210>  72
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  ACTB-P1

<400>  72
gggagctgtc acatccaggg tc                                                22


<210>  73
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  ACTB-P2

<400>  73
aagacggcaa tatggtggaa aa                                                22


<210>  74
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  ACTB-P3

<400>  74
ctgcccgaca accactacct                                                   20


<210>  75
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  ACTB-P4

<400>  75
ctaaggctgc tcaatgtcaa gg                                                22


<210>  76
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-P1

<400>  76
gggagctgtc acatccaggg tc                                                22


<210>  77
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-P2

<400>  77
catctccatc gagttcgacc ag                                                22


<210>  78
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-P3

<400>  78
ctgcccgaca accactacct                                                   20


<210>  79
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2-P4

<400>  79
ctaaggctgc tcaatgtcaa gg                                                22


<210>  80
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  spacer L

<400>  80
gagctggacg gcgacgtaaa cgg                                               23


<210>  81
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  spacer R

<400>  81
catgcccgaa ggctacgtcc agg                                               23


<210>  82
<211>  771
<212>  DNA
<213>  artificial

<220>
<223>  T2A-EGFP

<400>  82
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg cccagtgagc       60

aagggcgagg agctgttcac cggggtggtg cccatcctgg tcgaactcga tggagatgtg      120

aacggccaca agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg      180

accctgaagt tcatctgcac tacggggaaa ctgcccgtgc cctggcccac cctcgtgacc      240

accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa gcagcacgac      300

ttcttcaagt ccgccatgcc agagggatat gtgcaagagc gcaccatctt cttcaaggac      360

gacggcaact acaagacccg cgctgaagtc aaattcgagg gcgacaccct ggtgaaccgc      420

atcgagctga agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag      480

tacaactaca acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag      540

gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc cgaccactac      600

cagcagaaca cccccatcgg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc      660

acccagtccg ccctgagcaa agaccccaac gagaagcgcg atcacatggt cctgctggag      720

ttcgtgaccg ccgccgggat cactctcggc atggacgagc tgtacaagta a               771


<210>  83
<211>  800
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2 LHA

<400>  83
tggacctggc tggccgggac ctgactgact acctcatgaa gatcctcacc gagcgcggct       60

acagcttcac caccacggcc gagcgggaaa tcgtgcgtga cattaaggag aagctgtgct      120

acgtcgccct ggacttcgag caagagatgg ccacggctgc ttccagctcc tccctggaga      180

agagctacga gctgcctgac ggccaggtca tcaccattgg caatgagcgg ttccgctgcc      240

ctgaggcact cttccagcct tccttcctgg gtgagtggag actgtctccc ggctctgcct      300

gacatgaggg ttacccctcg gggctgtgct gtggaagcta agtcctgccc tcatttccct      360

ctcaggcatg gagtcctgtg gcatccacga aactaccttc aactccatca tgaagtgtga      420

cgtggacatc cgcaaagacc tgtacgccaa cacagtgctg tctggcggca ccaccatgta      480

ccctggcatt gccgacagga tgcagaagga gatcactgcc ctggcaccca gcacaatgaa      540

gatcaaggtg ggtgtctttc ctgcctgagc tgacctgggc aggtcggctg tggggtcctg      600

tggtgtgtgg ggagctgtca catccagggt cctcactgcc tgtccccttc cctcctcaga      660

tcattgctcc tcctgagcgc aagtactccg tgtggatcgg cggctccatc ctggcctcgc      720

tgtccacctt ccagcagatg tggatcagca agcaggagta tgacgagtcc ggcccctcca      780

tcgtccaccg caaatgcttc                                                  800


<210>  84
<211>  800
<212>  DNA
<213>  artificial

<220>
<223>  ACTB2 RHA

<400>  84
aggcggacta tgacttagtt gcgttacacc ctttcttgac aaaacctaac ttgcgcagaa       60

aacaagatga gattggcatg gctttatttg ttttttttgt tttgttttgg tttttttttt      120

ttttttggct tgactcagga tttaaaaact ggaacggtga aggtgacagc agtcggttgg      180

agcgagcatc ccccaaagtt cacaatgtgg ccgaggactt tgattgcaca ttgttgtttt      240

tttaatagtc attccaaata tgagatgcgt tgttacagga agtcccttgc catcctaaaa      300

gccaccccac ttctctctaa ggagaatggc ccagtcctct cccaagtcca cacaggggag      360

gtgatagcat tgctttcgtg taaattatgt aatgcaaaat ttttttaatc ttcgccttaa      420

tactttttta ttttgtttta ttttgaatga tgagccttcg tgccccccct tccccctttt      480

ttgtccccca acttgagatg tatgaaggct tttggtctcc ctgggagtgg gtggaggcag      540

ccagggctta cctgtacact gacttgagac cagttgaata aaagtgcaca ccttaaaaat      600

gaggccaagt gtgactttgt ggtgtggctg ggttgggggc agcagagggt gaaccctgca      660

ggagggtgaa ccctgcaaaa gggtggggca gtgggggcca acttgtcctt acccagagtg      720

caggtgtgtg gagatccctc ctgccttgac attgagcagc cttagagggt gggggaggct      780

caggggtcag gtctctgttc                                                  800


