                         б

<110>  ĴƼ޹˾
 
<120>  εĹȰøӦ

<130>  P2021TC1587

<150>  CN 202010659106.8
<151>  2020-07-09

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  457
<212>  PRT
<213>  Bacillus vedderi

<400>  1

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Ala Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  2
<211>  457
<212>  PRT
<213>  Lysinibacillus sphaericus

<400>  2

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Ala Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  3
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  3

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  4
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  4

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Cys Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  5
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  5

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  6
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  6

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  7
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  7

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  8
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  8

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  9
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  9

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Lys Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  10
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  10

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Arg Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  11
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  11

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  12
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  12

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Ile Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  13
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  13

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  14
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  14

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  15
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  15

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  16
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  16

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  17
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  17

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  18
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  18

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  19
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  19

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  20
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  20

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  21
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  21

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  22
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  22

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  23
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  23

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  24
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  24

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  25
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  25

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  26
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  26

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  27
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  27

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  28
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  28

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  29
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  29

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  30
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  30

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Val Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  31
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  31

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  32
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  32

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  33
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  33

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Leu Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  34
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  34

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  35
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  35

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  36
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  36

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Val Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  37
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  37

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  38
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  38

Met Thr Ile Thr Thr Val Ser Asn Glu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Gln Gln Asn Cys His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Val Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp His 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Val Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asp Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Ser Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Arg Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Leu Thr Lys Ala Ser Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Asn Glu Met Leu Lys Asp Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Gln Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Pro Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Ser Tyr Arg Pro Asn Ala Thr Phe Thr Asn Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Thr Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Glu Ser Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Ser Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asp Ile Tyr Ser Asp Ser Lys Ala Ala Ala Glu Lys Tyr Gly Phe Pro 
            420                 425                 430         


Gly Asn Leu Val Met Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Thr Glu Gly Ile Tyr 
    450                 455         


<210>  39
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  39

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  40
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  40

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  41
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  41

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Met Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  42
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  42

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  43
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  43

Met Thr Thr Thr Thr Val Ser Asn Ser Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  44
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  44

Met Thr Thr Thr Thr Val Ser Asn Leu Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  45
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  45

Met Thr Thr Thr Thr Val Ser Asn Tyr Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  46
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  46

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asp Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  47
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  47

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Trp Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  48
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  48

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  49
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  49

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Gly Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  50
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  50

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Glu Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  51
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  51

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ser Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  52
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  52

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Lys Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  53
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  53

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Gln Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  54
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  54

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  55
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  55

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Ser Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  56
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  56

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Asn Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Lys Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  57
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  57

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Trp Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  58
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  58

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Trp Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  59
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  59

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  60
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  60

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  61
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  61

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Gln Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  62
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  62

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Lys Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  63
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  63

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  64
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  64

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Trp Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Ala Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  65
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  65

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  66
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  66

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln His Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  67
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  67

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Leu Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  68
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  68

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Gly Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  69
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  69

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln His Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Leu Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Ala Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  70
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  70

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln His Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Phe Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Gly Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  71
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  71

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln Ala Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Leu Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Gly Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


<210>  72
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  72

Met Thr Thr Thr Thr Val Ser Asn Asp Gln Leu Ala Lys Glu Tyr Val 
1               5                   10                  15      


Asp Gly Val Phe Glu Glu Leu Lys Asn Gln Asn Ser His Gln His Glu 
            20                  25                  30          


Phe Leu Gln Ala Ala Glu Glu Ile Phe Ile Ser Leu Val Pro Val Phe 
        35                  40                  45              


Ala Gln His Pro Glu Tyr Ile Gln Ala Asn Ile Leu Ser Arg Ile Val 
    50                  55                  60                  


Glu Pro Asp Arg Ile Ile Ser Phe Arg Val Ala Trp Gln Asp Asp Asn 
65                  70                  75                  80  


Asn Gln Val Gln Val Asn Arg Gly Tyr Arg Val Gln Tyr Ser Asn Val 
                85                  90                  95      


Met Gly Pro Tyr Lys Gly Gly Leu Arg Phe His Pro Ser Val Asn Glu 
            100                 105                 110         


Ser Ile Ile Lys Phe Leu Gly Phe Glu Gln Ile Leu Lys Asn Ala Leu 
        115                 120                 125             


Thr Gly Gln Pro Ile Gly Gly Gly Lys Gly Gly Ser Asn Phe Asn Pro 
    130                 135                 140                 


Lys Gly Lys Ser Asp Ser Glu Ile Met Arg Phe Cys Gln Ala Phe Met 
145                 150                 155                 160 


Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Val Asp Gly Pro Gly Gly 
                165                 170                 175     


Asp Ile Gly Val Gly Ala Arg Glu Val Gly Tyr Leu Trp Gly Gln Tyr 
            180                 185                 190         


Lys Arg Ile Thr Lys Ala Tyr Glu Ser Gly Val Leu Thr Gly Lys Thr 
        195                 200                 205             


Pro Gly Tyr Gly Gly Ser Leu Gly Arg Lys Glu Ala Thr Gly Tyr Gly 
    210                 215                 220                 


Thr Val Tyr Phe Val Glu Glu Met Leu Lys Glu Val Asn Asp Ser Phe 
225                 230                 235                 240 


Glu Asp Lys Thr Val Val Val Ser Gly Ser Gly Asn Val Ser Thr Tyr 
                245                 250                 255     


Ala Ile Glu Lys Ala Gln Ala Tyr Gly Ala Lys Val Val Ala Cys Ser 
            260                 265                 270         


Asp Ser Ser Gly Tyr Ile Tyr Asp Ala Glu Gly Leu Asp Leu Asp Val 
        275                 280                 285             


Ile Lys Glu Ile Lys Glu Val Lys Gly Asp Arg Ile Ser Thr Tyr Val 
    290                 295                 300                 


Asp Tyr Arg Pro Asn Ala Thr Phe Thr Glu Gly Cys Thr Gly Ile Trp 
305                 310                 315                 320 


Ser Ile Pro Cys Asp Ile Ala Leu Pro Cys Ala Thr Gln Asn Glu Ile 
                325                 330                 335     


Asn Gly Asp Ala Ala Arg Thr Leu Ile Ser Asn Gly Val Lys Ala Ile 
            340                 345                 350         


Gly Glu Gly Ala Asn Met Pro Ser Asp Leu Glu Ala Ile Asn Glu Phe 
        355                 360                 365             


Leu Asn Ala Gly Val Leu Phe Gly Pro Ala Lys Ala Ala Asn Ala Gly 
    370                 375                 380                 


Gly Val Ala Val Ser Ala Leu Glu Met Ala Gln Asp Ser Ser Arg Val 
385                 390                 395                 400 


Phe Trp Thr Phe Glu Glu Val Asp Ala Lys Leu His Gln Ile Met Lys 
                405                 410                 415     


Asn Ile Tyr Arg Asp Ser Lys Ala Ala Ala Asp Lys Tyr Gly Tyr Pro 
            420                 425                 430         


Gly Asn Leu Val Val Gly Ala Asn Ile Ala Gly Phe Ile Lys Val Ala 
        435                 440                 445             


Asp Gly Met Leu Ala Glu Gly Ile Tyr 
    450                 455         


