                         SEQUENCE LISTING

<110>  㽭¡Ƽ޹˾
 
<120>  һαȮ

<130>  SHPCT2110207

<150>  CN202010661997.0
<151>  2020-07-10

<160>  8     

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1938
<212>  DNA
<213>  ˹

<400>  1
atggcttctg gcggcgcttt ttgcctgatc gccaacgacg gcaaggctga taagatcatc     60

ctggctcagg acctgctgaa ctcccggatc agcaatatca agaatgtgaa caagagctac    120

ggcaagccag atcccgagcc taccctgtct cagatcgagg agacacacct ggtgcatttc    180

aatgcccact tcaagccata cgtgcccgtg ggcttcgagt ataacaaggt gagaccccac    240

accggcacac ctaccctggg caataagctg acctttggca tcccacagta tggcgacttc    300

tttcatgata tggtgggcca ccatatcctg ggagcttgtc actccagctg gcaggacgct    360

ccaatccagg gcaccagcca gatgggcgct catggccagc tgcagacatt cccacgcaac    420

ggctacgact gggataatca gacccccctg gagggcgccg tgtatacact ggtggatcct    480

tttggcagac ctatcgtgcc aggcaccaag aacgcttacc gcaatctggt gtactattgc    540

gagtaccccg gcgagagact gtatgagaac gtgcgcttcg acgtgaatgg caactctctg    600

gacgagtact cttccgatgt gaccacactg gtgagaaagt tttgtatccc cggcgataag    660

atgaccggct ataagcacct ggtgggacag gaggtgagcg tggagggcac atctggccct    720

ctgctgtgca atatccacga cctgcataag ccacaccagt ctaagcccat cctgaccgac    780

gagaacgata cacagcgcac ctgttcccat acaaatccaa agttcctgag ccagcatttt    840

cccgagaact ctcacaatat ccagaccgcc ggcaagcagg atatcacacc tatcaccgac    900

gctacatacc tggatatcag gcggaacgtg cactattctt gcaatggccc ccagacacct    960

aagtactatc agccccctct ggccctgtgg atcaagctga ggttctggtt taatgagaac   1020

gtgaatctgg ctatcccttc cgtgtccatc ccattcggcg agcggtttat caccatcaag   1080

ctggcctccc agaaggacct ggtgaacgag ttcccaggcc tgtttgtgag gcagtcccgg   1140

ttcatcgctg gcaggcccag cagacgcaac atccggttca agccttggtt tatcccaggc   1200

gtgatcaatg agatctccct gaccaacaat gagctgtaca tcaacaatct gtttgtgaca   1260

cctgagatcc acaacctgtt cgtgaagagg gtgcggttta gcctgatccg ggtgcataag   1320

acccaggtga cacacaccaa caataaccac catgacgaga agctgatgag cgccctgaag   1380

tggccaatcg agtatatgtt catcggcctg aagcctacat ggaacatctc tgaccagaat   1440

ccacaccagc atagagattg gcataagttc ggccacgtgg tgaacgccat catgcagcct   1500

acccaccatg ctgagatcag ctttcaggac cgcgatacag ccctgccaga cgcttgcagc   1560

tctatctctg atatctcccc cgtgacctac cctatcacac tgccaatcat caagaacatc   1620

tccgtgaccg cccatggcat caatctgatc gacaagttcc ccagcaagtt ttgttccagc   1680

tacatccctt tccactatgg cggcaacgct atcaagaccc cagacgatcc cggcgccatg   1740

atgatcacat ttgctctgaa gcccagggag gagtaccagc cttccggcca catcaatgtg   1800

agcagagccc gcgagttcta catctcttgg gacaccgatt atgtgggctc catcaccaca   1860

gctgatctgg tggtgagcgc ctctgctatc aactttctgc tgctgcagaa tggctctgcc   1920

gtgctgcggt attccaca                                                 1938


<210>  2
<211>  1590
<212>  DNA
<213>  ˹

<400>  2
atggccgagt ttaacatcga cgagctgctg aagaatgtgc tggaggatcc atctaccgag     60

atctccgagg agacactgaa gcagctgtac cagcggacca acccctataa gcagttcaag    120

aatgacagca gagtggcttt ctgctctttt accaacctgc gcgagcagta catcaggcgg    180

ctgatcatga catccttcat cggctacgtg ttcaaggccc tgcaggagtg gatgccaagc    240

tactctaagc ccacccacac cacaaagaca ctgctgagcg agctgatcac actggtggac    300

accctgaagc aggagaccaa cgatgtgccc tccgagagcg tggtgaatac aatcctgagc    360

atcgctgatt cttgcaagac ccagacacag aagtctaagg aggccaagac cacaatcgac    420

tcctttctga gggagcactt cgtgtttgat cctaacctgc atgctcagtc tgcctacaca    480

tgtgctgaca ccaacgtgga tacatgcgct tccatgtgcg ccgacaccaa tgtggataca    540

tgcgcttcta tgtgcgctga tactaacgtg gacacctgcg cttccacctg tacaagcacc    600

gagtataccg acctggccga tcccgagaga atccctctgc acatcatgca gaagacactg    660

aacgtgccca atgagctgca ggctgacatc gatgccatca cacagacccc tcagggatac    720

agggctgctg ctcatatcct gcagaatatc gagctgcacc agagcatcaa gcatatgctg    780

gagaacccta gggccttcaa gccaatcctg tttaatacaa agatcacccg gtatctgtct    840

cagcacatcc cccctcagga caccttctac aagtggaact actatatcga ggataattat    900

gaggagctga gggctgccac agagtctatc tatccagaga agcccgacct ggagttcgct    960

tttatcatct acgacgtggt ggattccagc aaccagcaga aggtggacga gttctactat   1020

aagtacaagg atcagatctt ttctgaggtg tcttccatcc agctgggcaa ctggaccctg   1080

ctgggctcct tcaaggccaa tagagagagg tacaactact tcaaccagaa caatgagatc   1140

atcaagagga tcctggaccg gcacgaggag gatctgaaga tcggcaagga gatcctgaga   1200

aacaccatct atcataagaa ggctaagaat atccaggaga caggacctga cgctccagga   1260

ctgtctatct acaattccac attccatacc gattccggca tcaagggcct gctgagcttt   1320

aaggagctga agaacctgga gaaggcttcc ggcaatatca agaaggccag agagtacgac   1380

tttatcgacg attgtgagga gaagatcaag cagctgctga gcaaggagaa cctgacccct   1440

gacgaggagt ctgagctgat caagacaaag aagcagctgg ataacgctct ggagatgctg   1500

aatgtgccag acgataccat ccgcgtggat atgtgggtga acaataacaa taagctggag   1560

aaggagatcc tgtataccaa ggccgagctg                                    1590


<210>  3
<211>  1011
<212>  DNA
<213>  ˹

<400>  3
atgatcatcc tgatcttcct gatcttttct aacatcgtgc tgtccatcga ctactgggtg     60

tctttcaata agacaatcat cctggattcc aacatcacca atgacaacaa tgatatcaac    120

ggcgtgtcct ggaatttctt taacaatagc ttcaacaccc tggccacatg cggcaaggct    180

ggcaactttt gcgagtgttc taattactct acctccatct ataacatcac aaacaattgt    240

tccctgacca tcttcccaca caatgacgtg tttgatacca cataccaggt ggtgtggaac    300

cagatcatca attatacaat caagctgctg acccctgcca caccccctaa catcacctac    360

aactgcacaa attttctgat cacctgtaag aagaacaatg gcaccaacac aaatatctat    420

ctgaacatca atgacacctt cgtgaagtac acaaatgaga gcatcctgga gtacaactgg    480

aacaactcta acatcaacaa cttcaccgct acatgcatca tcaacaatac catcagcaca    540

tctaacgaga ccacactgat caattgtacc tacctgacac tgtccagcaa ctacttctat    600

accttcttta agctgtacag cctgaggaag cggaagaagc acgtggagga gatcgagtcc    660

ccaccccctg agagcaacga ggaggagcag tgccagcacg acgataccac atctatccat    720

gagccctccc ctagagagcc cctgctgcca aagccctaca gccgctacca gtataacaca    780

cctatctact atatgaggcc atctacccag cccctgaatc ctttcccact gcccaagcct    840

tgcccacccc ctaagccttg tccaccccct aagccatgcc caccacctaa gccatgtcca    900

tccgccgagt cctatagccc acccaagcct ctgccaagca tccccctgct gcctaacatc    960

cctccactga gcacccagaa tatctctctg atccatgtgg atagaatcat c            1011


<210>  4
<211>  79
<212>  DNA
<213>  ˹

<400>  4
gttcgtagaa gcggttgtgg cagcggatcc ccgcccggaa gcgcgccggg gacattgatt     60

attgactagt tattaatag                                                  79


<210>  5
<211>  68
<212>  DNA
<213>  ˹

<400>  5
tacacatggc tttatacgcg ccccgagccc cctcccacgc cgtcgtcgtt agacatgacc     60

atagagcc                                                              68


<210>  6
<211>  646
<212>  PRT
<213>  

<400>  6

Met Ala Ser Gly Gly Ala Phe Cys Leu Ile Ala Asn Asp Gly Lys Ala 
1               5                   10                  15      


Asp Lys Ile Ile Leu Ala Gln Asp Leu Leu Asn Ser Arg Ile Ser Asn 
            20                  25                  30          


Ile Lys Asn Val Asn Lys Ser Tyr Gly Lys Pro Asp Pro Glu Pro Thr 
        35                  40                  45              


Leu Ser Gln Ile Glu Glu Thr His Leu Val His Phe Asn Ala His Phe 
    50                  55                  60                  


Lys Pro Tyr Val Pro Val Gly Phe Glu Tyr Asn Lys Val Arg Pro His 
65                  70                  75                  80  


Thr Gly Thr Pro Thr Leu Gly Asn Lys Leu Thr Phe Gly Ile Pro Gln 
                85                  90                  95      


Tyr Gly Asp Phe Phe His Asp Met Val Gly His His Ile Leu Gly Ala 
            100                 105                 110         


Cys His Ser Ser Trp Gln Asp Ala Pro Ile Gln Gly Thr Ser Gln Met 
        115                 120                 125             


Gly Ala His Gly Gln Leu Gln Thr Phe Pro Arg Asn Gly Tyr Asp Trp 
    130                 135                 140                 


Asp Asn Gln Thr Pro Leu Glu Gly Ala Val Tyr Thr Leu Val Asp Pro 
145                 150                 155                 160 


Phe Gly Arg Pro Ile Val Pro Gly Thr Lys Asn Ala Tyr Arg Asn Leu 
                165                 170                 175     


Val Tyr Tyr Cys Glu Tyr Pro Gly Glu Arg Leu Tyr Glu Asn Val Arg 
            180                 185                 190         


Phe Asp Val Asn Gly Asn Ser Leu Asp Glu Tyr Ser Ser Asp Val Thr 
        195                 200                 205             


Thr Leu Val Arg Lys Phe Cys Ile Pro Gly Asp Lys Met Thr Gly Tyr 
    210                 215                 220                 


Lys His Leu Val Gly Gln Glu Val Ser Val Glu Gly Thr Ser Gly Pro 
225                 230                 235                 240 


Leu Leu Cys Asn Ile His Asp Leu His Lys Pro His Gln Ser Lys Pro 
                245                 250                 255     


Ile Leu Thr Asp Glu Asn Asp Thr Gln Arg Thr Cys Ser His Thr Asn 
            260                 265                 270         


Pro Lys Phe Leu Ser Gln His Phe Pro Glu Asn Ser His Asn Ile Gln 
        275                 280                 285             


Thr Ala Gly Lys Gln Asp Ile Thr Pro Ile Thr Asp Ala Thr Tyr Leu 
    290                 295                 300                 


Asp Ile Arg Arg Asn Val His Tyr Ser Cys Asn Gly Pro Gln Thr Pro 
305                 310                 315                 320 


Lys Tyr Tyr Gln Pro Pro Leu Ala Leu Trp Ile Lys Leu Arg Phe Trp 
                325                 330                 335     


Phe Asn Glu Asn Val Asn Leu Ala Ile Pro Ser Val Ser Ile Pro Phe 
            340                 345                 350         


Gly Glu Arg Phe Ile Thr Ile Lys Leu Ala Ser Gln Lys Asp Leu Val 
        355                 360                 365             


Asn Glu Phe Pro Gly Leu Phe Val Arg Gln Ser Arg Phe Ile Ala Gly 
    370                 375                 380                 


Arg Pro Ser Arg Arg Asn Ile Arg Phe Lys Pro Trp Phe Ile Pro Gly 
385                 390                 395                 400 


Val Ile Asn Glu Ile Ser Leu Thr Asn Asn Glu Leu Tyr Ile Asn Asn 
                405                 410                 415     


Leu Phe Val Thr Pro Glu Ile His Asn Leu Phe Val Lys Arg Val Arg 
            420                 425                 430         


Phe Ser Leu Ile Arg Val His Lys Thr Gln Val Thr His Thr Asn Asn 
        435                 440                 445             


Asn His His Asp Glu Lys Leu Met Ser Ala Leu Lys Trp Pro Ile Glu 
    450                 455                 460                 


Tyr Met Phe Ile Gly Leu Lys Pro Thr Trp Asn Ile Ser Asp Gln Asn 
465                 470                 475                 480 


Pro His Gln His Arg Asp Trp His Lys Phe Gly His Val Val Asn Ala 
                485                 490                 495     


Ile Met Gln Pro Thr His His Ala Glu Ile Ser Phe Gln Asp Arg Asp 
            500                 505                 510         


Thr Ala Leu Pro Asp Ala Cys Ser Ser Ile Ser Asp Ile Ser Pro Val 
        515                 520                 525             


Thr Tyr Pro Ile Thr Leu Pro Ile Ile Lys Asn Ile Ser Val Thr Ala 
    530                 535                 540                 


His Gly Ile Asn Leu Ile Asp Lys Phe Pro Ser Lys Phe Cys Ser Ser 
545                 550                 555                 560 


Tyr Ile Pro Phe His Tyr Gly Gly Asn Ala Ile Lys Thr Pro Asp Asp 
                565                 570                 575     


Pro Gly Ala Met Met Ile Thr Phe Ala Leu Lys Pro Arg Glu Glu Tyr 
            580                 585                 590         


Gln Pro Ser Gly His Ile Asn Val Ser Arg Ala Arg Glu Phe Tyr Ile 
        595                 600                 605             


Ser Trp Asp Thr Asp Tyr Val Gly Ser Ile Thr Thr Ala Asp Leu Val 
    610                 615                 620                 


Val Ser Ala Ser Ala Ile Asn Phe Leu Leu Leu Gln Asn Gly Ser Ala 
625                 630                 635                 640 


Val Leu Arg Tyr Ser Thr 
                645     


<210>  7
<211>  530
<212>  PRT
<213>  

<400>  7

Met Ala Glu Phe Asn Ile Asp Glu Leu Leu Lys Asn Val Leu Glu Asp 
1               5                   10                  15      


Pro Ser Thr Glu Ile Ser Glu Glu Thr Leu Lys Gln Leu Tyr Gln Arg 
            20                  25                  30          


Thr Asn Pro Tyr Lys Gln Phe Lys Asn Asp Ser Arg Val Ala Phe Cys 
        35                  40                  45              


Ser Phe Thr Asn Leu Arg Glu Gln Tyr Ile Arg Arg Leu Ile Met Thr 
    50                  55                  60                  


Ser Phe Ile Gly Tyr Val Phe Lys Ala Leu Gln Glu Trp Met Pro Ser 
65                  70                  75                  80  


Tyr Ser Lys Pro Thr His Thr Thr Lys Thr Leu Leu Ser Glu Leu Ile 
                85                  90                  95      


Thr Leu Val Asp Thr Leu Lys Gln Glu Thr Asn Asp Val Pro Ser Glu 
            100                 105                 110         


Ser Val Val Asn Thr Ile Leu Ser Ile Ala Asp Ser Cys Lys Thr Gln 
        115                 120                 125             


Thr Gln Lys Ser Lys Glu Ala Lys Thr Thr Ile Asp Ser Phe Leu Arg 
    130                 135                 140                 


Glu His Phe Val Phe Asp Pro Asn Leu His Ala Gln Ser Ala Tyr Thr 
145                 150                 155                 160 


Cys Ala Asp Thr Asn Val Asp Thr Cys Ala Ser Met Cys Ala Asp Thr 
                165                 170                 175     


Asn Val Asp Thr Cys Ala Ser Met Cys Ala Asp Thr Asn Val Asp Thr 
            180                 185                 190         


Cys Ala Ser Thr Cys Thr Ser Thr Glu Tyr Thr Asp Leu Ala Asp Pro 
        195                 200                 205             


Glu Arg Ile Pro Leu His Ile Met Gln Lys Thr Leu Asn Val Pro Asn 
    210                 215                 220                 


Glu Leu Gln Ala Asp Ile Asp Ala Ile Thr Gln Thr Pro Gln Gly Tyr 
225                 230                 235                 240 


Arg Ala Ala Ala His Ile Leu Gln Asn Ile Glu Leu His Gln Ser Ile 
                245                 250                 255     


Lys His Met Leu Glu Asn Pro Arg Ala Phe Lys Pro Ile Leu Phe Asn 
            260                 265                 270         


Thr Lys Ile Thr Arg Tyr Leu Ser Gln His Ile Pro Pro Gln Asp Thr 
        275                 280                 285             


Phe Tyr Lys Trp Asn Tyr Tyr Ile Glu Asp Asn Tyr Glu Glu Leu Arg 
    290                 295                 300                 


Ala Ala Thr Glu Ser Ile Tyr Pro Glu Lys Pro Asp Leu Glu Phe Ala 
305                 310                 315                 320 


Phe Ile Ile Tyr Asp Val Val Asp Ser Ser Asn Gln Gln Lys Val Asp 
                325                 330                 335     


Glu Phe Tyr Tyr Lys Tyr Lys Asp Gln Ile Phe Ser Glu Val Ser Ser 
            340                 345                 350         


Ile Gln Leu Gly Asn Trp Thr Leu Leu Gly Ser Phe Lys Ala Asn Arg 
        355                 360                 365             


Glu Arg Tyr Asn Tyr Phe Asn Gln Asn Asn Glu Ile Ile Lys Arg Ile 
    370                 375                 380                 


Leu Asp Arg His Glu Glu Asp Leu Lys Ile Gly Lys Glu Ile Leu Arg 
385                 390                 395                 400 


Asn Thr Ile Tyr His Lys Lys Ala Lys Asn Ile Gln Glu Thr Gly Pro 
                405                 410                 415     


Asp Ala Pro Gly Leu Ser Ile Tyr Asn Ser Thr Phe His Thr Asp Ser 
            420                 425                 430         


Gly Ile Lys Gly Leu Leu Ser Phe Lys Glu Leu Lys Asn Leu Glu Lys 
        435                 440                 445             


Ala Ser Gly Asn Ile Lys Lys Ala Arg Glu Tyr Asp Phe Ile Asp Asp 
    450                 455                 460                 


Cys Glu Glu Lys Ile Lys Gln Leu Leu Ser Lys Glu Asn Leu Thr Pro 
465                 470                 475                 480 


Asp Glu Glu Ser Glu Leu Ile Lys Thr Lys Lys Gln Leu Asp Asn Ala 
                485                 490                 495     


Leu Glu Met Leu Asn Val Pro Asp Asp Thr Ile Arg Val Asp Met Trp 
            500                 505                 510         


Val Asn Asn Asn Asn Lys Leu Glu Lys Glu Ile Leu Tyr Thr Lys Ala 
        515                 520                 525             


Glu Leu 
    530 


<210>  8
<211>  337
<212>  PRT
<213>  

<400>  8

Met Ile Ile Leu Ile Phe Leu Ile Phe Ser Asn Ile Val Leu Ser Ile 
1               5                   10                  15      


Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn Ile 
            20                  25                  30          


Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Phe Asn 
        35                  40                  45              


Asn Ser Phe Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe Cys 
    50                  55                  60                  


Glu Cys Ser Asn Tyr Ser Thr Ser Ile Tyr Asn Ile Thr Asn Asn Cys 
65                  70                  75                  80  


Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Asp Thr Thr Tyr Gln 
                85                  90                  95      


Val Val Trp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr Pro 
            100                 105                 110         


Ala Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile Thr 
        115                 120                 125             


Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Tyr Leu Asn Ile Asn 
    130                 135                 140                 


Asp Thr Phe Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn Trp 
145                 150                 155                 160 


Asn Asn Ser Asn Ile Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn Asn 
                165                 170                 175     


Thr Ile Ser Thr Ser Asn Glu Thr Thr Leu Ile Asn Cys Thr Tyr Leu 
            180                 185                 190         


Thr Leu Ser Ser Asn Tyr Phe Tyr Thr Phe Phe Lys Leu Tyr Ser Leu 
        195                 200                 205             


Arg Lys Arg Lys Lys His Val Glu Glu Ile Glu Ser Pro Pro Pro Glu 
    210                 215                 220                 


Ser Asn Glu Glu Glu Gln Cys Gln His Asp Asp Thr Thr Ser Ile His 
225                 230                 235                 240 


Glu Pro Ser Pro Arg Glu Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr 
                245                 250                 255     


Gln Tyr Asn Thr Pro Ile Tyr Tyr Met Arg Pro Ser Thr Gln Pro Leu 
            260                 265                 270         


Asn Pro Phe Pro Leu Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro 
        275                 280                 285             


Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Ser Ala Glu Ser 
    290                 295                 300                 


Tyr Ser Pro Pro Lys Pro Leu Pro Ser Ile Pro Leu Leu Pro Asn Ile 
305                 310                 315                 320 


Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His Val Asp Arg Ile 
                325                 330                 335     


Ile 
    


