                         б

<110>  Ĵײ̩ҽҩɷ޹˾
 
<120>  BCMACD19ǶϿԭCARCAR弰Ӧ

<130>  IEC200444PCT

<150>  CN202010644219.0
<151>  2020-07-06

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA VH ԴBCMAɱ


<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Leu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  2
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA VL ԴBCMAɱ


<400>  2

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala 
    


<210>  3
<211>  120
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 VH ԴCD19ɱ


<400>  3

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  106
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 VL ԴCD19ɱ


<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105     


<210>  5
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA VH CDR1

<400>  5

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  6
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA VH CDR2

<400>  6

Asn Thr Glu Thr Gly Glu 
1               5       


<210>  7
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA VH CDR3

<400>  7

Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe Thr Tyr 
1               5                   10      


<210>  8
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA VL CDR1

<400>  8

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His 
1               5                   10                  15      


<210>  9
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA VL CDR2

<400>  9

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  10
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA VL CDR3

<400>  10

Met Gln Ser Thr His Val Leu Thr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 VH CDR1

<400>  11

Gly Val Ser Leu Pro Asp Tyr Gly 
1               5               


<210>  12
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 VH CDR2

<400>  12

Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
1               5                   10  


<210>  13
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 VH CDR3

<400>  13

Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  14
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 VL CDR1

<400>  14

Gln Asp Ile Ser Lys Tyr 
1               5       


<210>  15
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 VL CDR2

<400>  15

His Thr Ser Arg Leu His Ser Gly Ile Pro Asp 
1               5                   10      


<210>  16
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 VL CDR3

<400>  16

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  17
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  Linker1

<400>  17

Gly Gly Gly Gly Ser 
1               5   


<210>  18
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  Linker2

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  19
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  Linker3

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  20
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  Linker4

<400>  20

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  21
<211>  45
<212>  PRT
<213>  ˹

<220>
<223>  CD8 

<400>  21

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  22
<211>  24
<212>  PRT
<213>  ˹

<220>
<223>  CD8TM

<400>  22

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  23
<211>  42
<212>  PRT
<213>  ˹

<220>
<223>  4-1BBźŴṹ򰱻

<400>  23

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  24
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  CD3ưźŴṹ򰱻-1

<400>  24

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  25
<211>  246
<212>  PRT
<213>  ˹

<220>
<223>  Դ-BCMA scFv

<400>  25

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Phe Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
        115                 120                 125             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    130                 135                 140                 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ser Met 
145                 150                 155                 160 


Asp Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
                165                 170                 175     


Ile Asn Thr Glu Thr Gly Glu Ser Thr Tyr Ala Gln Lys Leu Gln Gly 
            180                 185                 190         


Arg Val Thr Phe Ser Leu Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys Ala Pro 
    210                 215                 220                 


Ser Leu Phe Tyr Gly Tyr Ser Trp Phe Pro Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  26
<211>  242
<212>  PRT
<213>  ˹

<220>
<223>  FMC63(Դ-CD19) scFv

<400>  26

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  27
<211>  247
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA scFv

<400>  27

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
145                 150                 155                 160 


Leu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                165                 170                 175     


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
            180                 185                 190         


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe Thr Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser 
                245         


<210>  28
<211>  241
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 scFv

<400>  28

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Leu Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile 
    


<210>  29
<211>  491
<212>  PRT
<213>  ˹

<220>
<223>  H-BCMA CAR

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
        195                 200                 205             


Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
    210                 215                 220                 


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe 
                245                 250                 255     


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  30
<211>  485
<212>  PRT
<213>  ˹

<220>
<223>  H-CD19 CAR

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu 
            20                  25                  30          


Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val 
        35                  40                  45              


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
        195                 200                 205             


Arg Leu His Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ile Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  31
<211>  738
<212>  DNA
<213>  ˹

<220>
<223>  Դ-BCMA scFv

<400>  31
gacgtggtca tgacacagag ccctctgagc ctgcctgtga cactgggaca gcctgccagc       60

atcagctgta gaagcagcca gagcctggtg cacagcaacg gcaatacctt cctgcactgg      120

tatcagcaga ggcccggaca gtctcccaga ctgctgatct tcaaggtgtc caaccggttc      180

agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tacttctgta gccagagcac ccacgtgctg      300

acctttggcc agggcaccaa gctggaaatc aagggaggcg gaggttctgg cggcggagga      360

agtggtggcg gaggctctca gattcagctg gtgcagtctg gcgccgaagt gaagaaacct      420

ggcgcctctg tgaaggtgtc ctgcaaggcc agcggctaca cctttaccga ctacagcatg      480

gactggctga gacaggcccc tggacaaggc ttggaatgga tgggctggat caacaccgag      540

acaggcgaga gcacatacgc ccagaaactg cagggcagag tgaccttcag cctggacacc      600

agcacaagca ccgcctacat ggaactgcgg agcctgagat ccgatgatac cgccgtgtac      660

ttctgcgccc ctagcctgtt ttacggctac agctggttcc cctattgggg ccagggaacc      720

ctggtcacag tcagctct                                                    738


<210>  32
<211>  726
<212>  DNA
<213>  ˹

<220>
<223>  FMC63(Դ-CD19) scFv

<400>  32
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  33
<211>  741
<212>  DNA
<213>  ˹

<220>
<223>  H-BCMA scFv

<400>  33
gacatcgtga tgacacagag ccctctgagc ctgcctgtga cacctggcga acctgccagc       60

atcagctgta gaagcagcca gagcctggtg cacagcaacg gcaatacctt cctgcactgg      120

tatctgcaga agcccggcca gtctcctcag ctgctgatct acaaggtgtc caaccggttc      180

agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgta tgcagagcac ccacgtgctg      300

acctttggcg gcggaacaaa gctggaaatc aagcgggctg gtggaggtgg cagcggagga      360

ggtgggtccg gcggtggagg aagccaggtt cagctggttc agtctggcgc cgaagtgaag      420

aaacctggcg cctctgtgaa ggtgtcctgc aaggccagcg gctacacctt taccgactac      480

ctgatgcact gggtccgaca ggctccagga caaggcttgg aatggatggg ctggatcaac      540

accgagacag gcgagcctac ctacgccgac gatttcaagg gcagagtgac catgaccaga      600

gacaccagca cctccaccgt gtacatggaa ctgagcagcc tgagaagcga ggacaccgcc      660

gtgtactact gtgcccctag cctgtactac ggctactcct ggtttaccta ctggggccag      720

ggcaccctgg tcacagtttc t                                                741


<210>  34
<211>  723
<212>  DNA
<213>  ˹

<220>
<223>  H-CD19 scFv

<400>  34
caggtcaccc tgagagagag cggaccagcc ctggtgaaac ctacacagac cctgaccctg       60

acctgcacct ttagcggagt gtccctgcca gactacggag tgtcttggat ccggcagcca      120

ccaggaaaag ctctcgagtg gctcgcagtg atttggggca gcgagaccac ctactacaac      180

agcgccctga agagcaggct gaccatcagc aaggacacca gcaagaacca ggtggtgctg      240

accatgacca acatggaccc cgtggacacc gccacctact attgcgccaa gcactactac      300

tacggcggca gctacgccat ggactattgg ggacagggca ccaccgtgac agtgtctagc      360

ggaggaggag gaagcggagg aggaggatct ggaggaggag gcagcgagat tgtgctgaca      420

cagagcccag ccacactgtc tctgagccca ggagagagag ccacactgtc ttgcagggcc      480

agccaggaca tcagcaagta cctgaattgg taccagcaga agcccggcca ggctcctagg      540

ctgctgatct accacaccag caggctgcac agcggcatcc cagacagatt cagcggaagc      600

ggcagcggca cagacttcac cctgaccatc agcagactgg agcccgagga catcgccgtg      660

tactattgcc agcagggcaa caccctgccc tacacctttg gacagggcac caagctggag      720

atc                                                                    723


<210>  35
<211>  1473
<212>  DNA
<213>  ˹

<220>
<223>  H-BCMA CAR

<400>  35
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgacatcg tgatgacaca gagccctctg agcctgcctg tgacacctgg cgaacctgcc      120

agcatcagct gtagaagcag ccagagcctg gtgcacagca acggcaatac cttcctgcac      180

tggtatctgc agaagcccgg ccagtctcct cagctgctga tctacaaggt gtccaaccgg      240

ttcagcggcg tgcccgatag attttctggc agcggctctg gcaccgactt caccctgaag      300

atctccagag tggaagccga ggacgtgggc gtgtactact gtatgcagag cacccacgtg      360

ctgacctttg gcggcggaac aaagctggaa atcaagcggg ctggtggagg tggcagcgga      420

ggaggtgggt ccggcggtgg aggaagccag gttcagctgg ttcagtctgg cgccgaagtg      480

aagaaacctg gcgcctctgt gaaggtgtcc tgcaaggcca gcggctacac ctttaccgac      540

tacctgatgc actgggtccg acaggctcca ggacaaggct tggaatggat gggctggatc      600

aacaccgaga caggcgagcc tacctacgcc gacgatttca agggcagagt gaccatgacc      660

agagacacca gcacctccac cgtgtacatg gaactgagca gcctgagaag cgaggacacc      720

gccgtgtact actgtgcccc tagcctgtac tacggctact cctggtttac ctactggggc      780

cagggcaccc tggtcacagt ttctaccacg acgccagcgc cgcgaccacc aacaccggcg      840

cccaccatcg cgtcgcagcc cctgtccctg cgcccagaag cgtgccggcc agcggcgggg      900

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatttg ggcccctctg      960

gctggtactt gcggggtcct gctgctttca ctcgtgatca ctctttactg taagcgcggt     1020

cggaagaagc tgctgtacat ctttaagcaa cccttcatga ggcctgtgca gactactcaa     1080

gaggaggacg gctgttcatg ccggttccca gaggaggagg aaggcggctg cgaactgcgc     1140

gtgaaattca gccgcagcgc agatgctcca gcctacaagc aggggcagaa ccagctctac     1200

aacgaactca atcttggtcg gagagaggag tacgacgtgc tggacaagcg gagaggacgg     1260

gacccagaaa tgggcgggaa gccgcgcaga aagaatcccc aagagggcct gtacaacgag     1320

ctccaaaagg ataagatggc agaagcctat agcgagattg gtatgaaagg ggaacgcaga     1380

agaggcaaag gccacgacgg actgtaccag ggactcagca ccgccaccaa ggacacctat     1440

gacgctcttc acatgcaggc cctgccgcct cgg                                  1473


<210>  36
<211>  1455
<212>  DNA
<213>  ˹

<220>
<223>  H-CD19 CAR

<400>  36
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccaggtca ccctgagaga gagcggacca gccctggtga aacctacaca gaccctgacc      120

ctgacctgca cctttagcgg agtgtccctg ccagactacg gagtgtcttg gatccggcag      180

ccaccaggaa aagctctcga gtggctcgca gtgatttggg gcagcgagac cacctactac      240

aacagcgccc tgaagagcag gctgaccatc agcaaggaca ccagcaagaa ccaggtggtg      300

ctgaccatga ccaacatgga ccccgtggac accgccacct actattgcgc caagcactac      360

tactacggcg gcagctacgc catggactat tggggacagg gcaccaccgt gacagtgtct      420

agcggaggag gaggaagcgg aggaggagga tctggaggag gaggcagcga gattgtgctg      480

acacagagcc cagccacact gtctctgagc ccaggagaga gagccacact gtcttgcagg      540

gccagccagg acatcagcaa gtacctgaat tggtaccagc agaagcccgg ccaggctcct      600

aggctgctga tctaccacac cagcaggctg cacagcggca tcccagacag attcagcgga      660

agcggcagcg gcacagactt caccctgacc atcagcagac tggagcccga ggacatcgcc      720

gtgtactatt gccagcaggg caacaccctg ccctacacct ttggacaggg caccaagctg      780

gagatcacca ctaccccagc accgaggcca cccaccccgg ctcctaccat cgcctcccag      840

cctctgtccc tgcgtccgga ggcatgtaga cccgcagctg gtggggccgt gcatacccgt      900

ggtcttgact tcgcctgcga tatctacatt tgggcccctc tggctggtac ttgcggggtc      960

ctgctgcttt cactcgtgat cactctttac tgtaagcgcg gtcggaagaa gctgctgtac     1020

atctttaagc aacccttcat gaggcctgtg cagactactc aagaggagga cggctgttca     1080

tgccggttcc cagaggagga ggaaggcggc tgcgaactgc gcgtgaaatt cagccgcagc     1140

gcagatgctc cagcctacaa gcaggggcag aaccagctct acaacgaact caatcttggt     1200

cggagagagg agtacgacgt gctggacaag cggagaggac gggacccaga aatgggcggg     1260

aagccgcgca gaaagaatcc ccaagagggc ctgtacaacg agctccaaaa ggataagatg     1320

gcagaagcct atagcgagat tggtatgaaa ggggaacgca gaagaggcaa aggccacgac     1380

ggactgtacc agggactcag caccgccacc aaggacacct atgacgctct tcacatgcag     1440

gccctgccgc ctcgg                                                      1455


<210>  37
<211>  752
<212>  PRT
<213>  ˹

<220>
<223>  TanCAR 01ȫ

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
        195                 200                 205             


Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
    210                 215                 220                 


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe 
                245                 250                 255     


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    290                 295                 300                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val Ser Leu Pro Asp Tyr 
305                 310                 315                 320 


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
                325                 330                 335     


Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
            340                 345                 350         


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
        355                 360                 365             


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
    370                 375                 380                 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
            420                 425                 430         


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        435                 440                 445             


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
465                 470                 475                 480 


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Arg Leu Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    530                 535                 540                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
545                 550                 555                 560 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                565                 570                 575     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            580                 585                 590         


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        595                 600                 605             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    610                 615                 620                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
625                 630                 635                 640 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                645                 650                 655     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            660                 665                 670         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        675                 680                 685             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    690                 695                 700                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
705                 710                 715                 720 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                725                 730                 735     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 750         


<210>  38
<211>  747
<212>  PRT
<213>  ˹

<220>
<223>  TanCAR 02ȫ

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
        195                 200                 205             


Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
    210                 215                 220                 


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe 
                245                 250                 255     


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Glu Ala Ala Ala 
            260                 265                 270         


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gln Val Thr Leu Arg 
        275                 280                 285             


Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr 
    290                 295                 300                 


Cys Thr Phe Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile 
305                 310                 315                 320 


Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Val Ile Trp Gly 
                325                 330                 335     


Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile 
            340                 345                 350         


Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met 
        355                 360                 365             


Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr 
    370                 375                 380                 


Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
            420                 425                 430         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        435                 440                 445             


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    450                 455                 460                 


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Asp Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
                485                 490                 495     


Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Gly Asn Thr Leu 
            500                 505                 510         


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Thr Thr Thr Pro 
        515                 520                 525             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    530                 535                 540                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
545                 550                 555                 560 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                565                 570                 575     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            580                 585                 590         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        595                 600                 605             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    610                 615                 620                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
625                 630                 635                 640 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                645                 650                 655     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            660                 665                 670         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        675                 680                 685             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    690                 695                 700                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
705                 710                 715                 720 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                725                 730                 735     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745         


<210>  39
<211>  752
<212>  PRT
<213>  ˹

<220>
<223>  TanCAR 03ȫ

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu 
            20                  25                  30          


Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val 
        35                  40                  45              


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
        195                 200                 205             


Arg Leu His Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ile Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
        275                 280                 285             


Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser 
    290                 295                 300                 


Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu 
305                 310                 315                 320 


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
                325                 330                 335     


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
            340                 345                 350         


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
        355                 360                 365             


Asp Val Gly Val Tyr Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe 
    370                 375                 380                 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
                405                 410                 415     


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            420                 425                 430         


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg 
        435                 440                 445             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu 
    450                 455                 460                 


Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met 
465                 470                 475                 480 


Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu 
                485                 490                 495     


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr 
            500                 505                 510         


Gly Tyr Ser Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        515                 520                 525             


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    530                 535                 540                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
545                 550                 555                 560 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                565                 570                 575     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            580                 585                 590         


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        595                 600                 605             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    610                 615                 620                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
625                 630                 635                 640 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                645                 650                 655     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            660                 665                 670         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        675                 680                 685             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    690                 695                 700                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
705                 710                 715                 720 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                725                 730                 735     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 750         


<210>  40
<211>  747
<212>  PRT
<213>  ˹

<220>
<223>  TanCAR 04ȫ

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu 
            20                  25                  30          


Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val 
        35                  40                  45              


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
        195                 200                 205             


Arg Leu His Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ile Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            260                 265                 270         


Glu Ala Ala Ala Lys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
        275                 280                 285             


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
    290                 295                 300                 


Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln 
305                 310                 315                 320 


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
                325                 330                 335     


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            340                 345                 350         


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
        355                 360                 365             


Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys 
    370                 375                 380                 


Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
                405                 410                 415     


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
            420                 425                 430         


Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg Gln Ala Pro Gly Gln 
        435                 440                 445             


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
    450                 455                 460                 


Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
465                 470                 475                 480 


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
                485                 490                 495     


Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe 
            500                 505                 510         


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Thr Thr Thr Pro 
        515                 520                 525             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    530                 535                 540                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
545                 550                 555                 560 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                565                 570                 575     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            580                 585                 590         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        595                 600                 605             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    610                 615                 620                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
625                 630                 635                 640 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                645                 650                 655     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            660                 665                 670         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        675                 680                 685             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    690                 695                 700                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
705                 710                 715                 720 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                725                 730                 735     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745         


<210>  41
<211>  732
<212>  PRT
<213>  ˹

<220>
<223>  TanCAR 05ȫ

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    130                 135                 140                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
145                 150                 155                 160 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Leu Met His Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr 
            180                 185                 190         


Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr 
        195                 200                 205             


Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser 
    210                 215                 220                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr 
225                 230                 235                 240 


Tyr Gly Tyr Ser Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Val Thr Leu Arg Glu Ser Gly Pro Ala 
        275                 280                 285             


Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
    290                 295                 300                 


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
305                 310                 315                 320 


Lys Ala Leu Glu Trp Leu Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr 
                325                 330                 335     


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser 
            340                 345                 350         


Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr 
        355                 360                 365             


Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
    370                 375                 380                 


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
                405                 410                 415     


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile 
            420                 425                 430         


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        435                 440                 445             


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Asp Arg 
    450                 455                 460                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
465                 470                 475                 480 


Leu Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Gly Asn Thr 
                485                 490                 495     


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Thr Thr Thr 
            500                 505                 510         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        515                 520                 525             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    530                 535                 540                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
545                 550                 555                 560 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                565                 570                 575     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            580                 585                 590         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        595                 600                 605             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    610                 615                 620                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
625                 630                 635                 640 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                645                 650                 655     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            660                 665                 670         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        675                 680                 685             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    690                 695                 700                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
705                 710                 715                 720 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730         


<210>  42
<211>  732
<212>  PRT
<213>  ˹

<220>
<223>  TanCAR 06ȫ

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu 
            20                  25                  30          


Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val 
        35                  40                  45              


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
145                 150                 155                 160 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
                165                 170                 175     


His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly 
            180                 185                 190         


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
225                 230                 235                 240 


Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
                245                 250                 255     


Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
        275                 280                 285             


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
    290                 295                 300                 


Gly Tyr Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu 
                325                 330                 335     


Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Arg Asp 
            340                 345                 350         


Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser 
    370                 375                 380                 


Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
                405                 410                 415     


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile 
            420                 425                 430         


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        435                 440                 445             


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Asp Arg 
    450                 455                 460                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
465                 470                 475                 480 


Leu Glu Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Gly Asn Thr 
                485                 490                 495     


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Thr Thr Thr 
            500                 505                 510         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        515                 520                 525             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    530                 535                 540                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
545                 550                 555                 560 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                565                 570                 575     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            580                 585                 590         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        595                 600                 605             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    610                 615                 620                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
625                 630                 635                 640 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                645                 650                 655     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            660                 665                 670         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        675                 680                 685             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    690                 695                 700                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
705                 710                 715                 720 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730         


<210>  43
<211>  2256
<212>  DNA
<213>  ˹

<220>
<223>  TanCAR 01

<400>  43
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgccgccaga       60

cccgacatcg tgatgaccca gagcccactg tccctgccag tgacaccagg agagcctgca      120

agcatctcct gcaggagctc ccagtccctg gtgcactcta acggcaatac cttcctgcac      180

tggtatctgc agaagccagg ccagtccccc cagctgctga tctacaaggt gagcaaccgg      240

ttctccggcg tgccagacag attttctggc agcggctccg gcaccgattt cacactgaag      300

atcagcagag tggaggccga ggacgtgggc gtgtactatt gcatgcagtc cacccacgtg      360

ctgacatttg gcggcggcac caagctggag atcaagaggg ccggaggagg aggatctgga      420

ggaggaggct ccggcggcgg cggctcccag gtgcagctgg tgcagagcgg agcagaggtg      480

aagaagccag gagcctctgt gaaggtgagc tgtaaggcct ccggctatac cttcacagat      540

tacctgatgc actgggtgcg ccaggcacct ggacagggac tggagtggat gggctggatc      600

aataccgaga caggcgagcc aacctatgcc gacgacttca agggccgggt gaccatgaca      660

agagacacct ctacaagcac cgtgtacatg gagctgtcta gcctgcggtc cgaggatacc      720

gccgtgtact attgcgcccc ttccctgtac tatggctatt cttggttcac atactggggc      780

cagggcaccc tggtgacagt gtctggagga ggaggaagtg gaggaggagg atccggcggc      840

ggcggctctg gcggcggcgg cagccaggtg accctgaggg agagcggccc cgccctggtg      900

aagcctacac agaccctgac actgacctgt acattttctg gcgtgagcct gcccgattac      960

ggcgtgtctt ggatcaggca gccacctggc aaggccctgg agtggctggc cgtgatctgg     1020

ggcagcgaga ccacatacta taactctgcc ctgaagagcc ggctgaccat ctccaaggac     1080

acatctaaga accaggtggt gctgaccatg acaaatatgg accctgtgga taccgccaca     1140

tactattgcg ccaagcacta ctattacggc ggctcctatg ccatggatta ttggggacag     1200

ggcactacag tgaccgtgtc ctctggagga ggaggatccg gaggaggagg aagcggcggc     1260

ggcggcagcg agatcgtgct gacccagagc cctgccacac tgtccctgtc tccaggagag     1320

agggccacac tgagctgtag ggcatcccag gacatctcta agtatctgaa ctggtaccag     1380

cagaagcctg gccaggcccc aaggctgctg atctatcaca ccagcaggct gcactccggc     1440

atccccgacc ggttcagcgg atccggatct ggcacagact tcaccctgac aatcagccgg     1500

ctggagccag aggatatcgc cgtgtattac tgtcagcagg gcaataccct gccctacaca     1560

tttggccagg gaactaagct ggagatcacc acgacgccag cgccgcgacc accaacaccg     1620

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aagcgtgccg gccagcggcg     1680

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ttgggcccct     1740

ctggctggta cttgcggggt cctgctgctt tcactcgtga tcactcttta ctgtaagcgc     1800

ggtcggaaga agctgctgta catctttaag caacccttca tgaggcctgt gcagactact     1860

caagaggagg acggctgttc atgccggttc ccagaggagg aggaaggcgg ctgcgaactg     1920

cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc     1980

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga     2040

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac     2100

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc     2160

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc     2220

tatgacgctc ttcacatgca ggccctgccg cctcgg                               2256


<210>  44
<211>  2241
<212>  DNA
<213>  ˹

<220>
<223>  TanCAR 02

<400>  44
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgccgccaga       60

cccgacatcg tgatgaccca gagcccactg tccctgccag tgacaccagg agagcctgca      120

agcatctcct gcaggagctc ccagtccctg gtgcactcta acggcaatac cttcctgcac      180

tggtatctgc agaagccagg ccagagcccc cagctgctga tctacaaggt gagcaaccgg      240

ttctccggcg tgccagacag attttctggc agcggctccg gcaccgattt cacactgaag      300

atctccagag tggaggccga ggacgtgggc gtgtactatt gcatgcagtc tacccacgtg      360

ctgacatttg gcggcggcac caagctggag atcaagaggg ccggaggagg aggatctgga      420

ggaggaggct ccggcggcgg cggctcccag gtgcagctgg tgcagagcgg agcagaggtg      480

aagaagccag gagcctctgt gaaggtgagc tgtaaggcct ccggctatac cttcacagat      540

tacctgatgc actgggtgcg ccaggcacct ggacagggac tggagtggat gggctggatc      600

aataccgaga caggcgagcc aacctatgcc gacgacttca agggccgggt gaccatgaca      660

agagacacct ctacaagcac cgtgtacatg gagctgtcta gcctgcggtc cgaggatacc      720

gccgtgtact attgcgcccc ttctctgtac tatggctata gctggttcac atactggggc      780

cagggcaccc tggtgacagt gtctgaggca gcagcaaagg aggcagcagc caaggaggca      840

gcagcaaagc aggtgaccct gagggagtcc ggacccgccc tggtgaagcc tacacagacc      900

ctgacactga cctgtacatt ttctggcgtg agcctgcccg attacggcgt gagctggatc      960

aggcagccac ctggcaaggc cctggagtgg ctggccgtga tctggggctc cgagaccaca     1020

tactataact ctgccctgaa gagccggctg accatctcca aggacacatc taagaaccag     1080

gtggtgctga ccatgacaaa tatggaccct gtggataccg ccacatacta ttgcgccaag     1140

cactactatt acggcggcag ctatgccatg gattattggg gacagggcac tacagtgacc     1200

gtgtcctctg gcggcggcgg ctctggagga ggaggatccg gaggaggagg atccgagatc     1260

gtgctgaccc agtcccctgc cacactgtcc ctgtctccag gagagagggc cacactgagc     1320

tgtagggcat cccaggacat ctctaagtat ctgaactggt accagcagaa gcctggccag     1380

gccccaaggc tgctgatcta tcacaccagc aggctgcact ccggcatccc cgaccggttc     1440

agcggatccg gatctggcac agacttcacc ctgacaatca gccggctgga gccagaggat     1500

atcgccgtgt attactgtca gcagggcaat accctgccct acacatttgg ccagggaact     1560

aagctggaga tcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1620

tcgcagcccc tgtccctgcg cccagaagcg tgccggccag cggcgggggg cgcagtgcac     1680

acgagggggc tggacttcgc ctgtgatatc tacatttggg cccctctggc tggtacttgc     1740

ggggtcctgc tgctttcact cgtgatcact ctttactgta agcgcggtcg gaagaagctg     1800

ctgtacatct ttaagcaacc cttcatgagg cctgtgcaga ctactcaaga ggaggacggc     1860

tgttcatgcc ggttcccaga ggaggaggaa ggcggctgcg aactgcgcgt gaaattcagc     1920

cgcagcgcag atgctccagc ctacaagcag gggcagaacc agctctacaa cgaactcaat     1980

cttggtcgga gagaggagta cgacgtgctg gacaagcgga gaggacggga cccagaaatg     2040

ggcgggaagc cgcgcagaaa gaatccccaa gagggcctgt acaacgagct ccaaaaggat     2100

aagatggcag aagcctatag cgagattggt atgaaagggg aacgcagaag aggcaaaggc     2160

cacgacggac tgtaccaggg actcagcacc gccaccaagg acacctatga cgctcttcac     2220

atgcaggccc tgccgcctcg g                                               2241


<210>  45
<211>  2256
<212>  DNA
<213>  ˹

<220>
<223>  TanCAR 03

<400>  45
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagcaagg       60

cctcaggtga cactgaggga gagcggaccc gccctggtga agcctaccca gacactgacc      120

ctgacatgca ccttcagcgg cgtgtccctg ccagactacg gcgtgtcctg gatcaggcag      180

ccacctggca aggccctgga gtggctggcc gtgatctggg gctctgagac cacatactat      240

aactccgccc tgaagtctcg gctgaccatc agcaaggaca catccaagaa ccaggtggtg      300

ctgacaatga ccaatatgga ccctgtggat acagccacct actattgcgc caagcactac      360

tattacggcg gcagctatgc catggattac tggggccagg gcaccacagt gaccgtgagc      420

tccggaggcg gcggctctgg aggaggagga agcggaggag gaggatccga gatcgtgctg      480

acccagtccc ctgccacact gagcctgtcc ccaggagaga gggccaccct gtcttgtaga      540

gccagccagg atatctccaa gtatctgaac tggtaccagc agaagccagg acaggcacca      600

aggctgctga tctatcacac ctctagactg cacagcggca tccccgacag gttctctgga      660

agcggatccg gcacagactt caccctgacc atcagcaggc tggagcccga ggacatcgcc      720

gtgtattact gccagcaggg caataccctg ccttacacat tcggccaggg aaccaagctg      780

gagatcggag gaggaggatc cggcggcggc ggctccggcg gcggcgggag cggcggcggc      840

ggctctgata tcgtgatgac ccagtctcca ctgagcctgc ctgtgacacc aggagagcct      900

gcctctatca gctgtcggtc tagccagtcc ctggtgcact ctaacggcaa tacctttctg      960

cactggtatc tgcagaagcc tggccagagc ccacagctgc tgatctacaa ggtgagcaac     1020

aggttctccg gcgtgcctga ccgcttttcc ggctctggca gcggcaccga tttcacactg     1080

aagatctcta gagtggaggc cgaggacgtg ggcgtgtatt actgcatgca gagcacccac     1140

gtgctgacat ttggcggcgg caccaagctg gagatcaaga gggcaggcgg cggcggcagc     1200

ggaggaggag ggtctggcgg cggcggctct caggtgcagc tggtgcagtc cggagcagag     1260

gtgaagaagc caggagcctc tgtgaaggtg agctgtaagg cctccggcta tacattcacc     1320

gattacctga tgcactgggt gcgccaggca ccaggacagg gactggagtg gatgggctgg     1380

atcaatacag agaccggcga gcccacctat gccgacgact tcaagggccg ggtgacaatg     1440

accagagaca catccacctc tacagtgtac atggagctgt cctctctgcg gagcgaggat     1500

accgccgtgt attactgtgc ccccagcctg tattacggct attcctggtt tacatattgg     1560

ggacagggca ccctggtgac agtgtccacc acgacgccag cgccgcgacc accaacaccg     1620

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aagcgtgccg gccagcggcg     1680

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ttgggcccct     1740

ctggctggta cttgcggggt cctgctgctt tcactcgtga tcactcttta ctgtaagcgc     1800

ggtcggaaga agctgctgta catctttaag caacccttca tgaggcctgt gcagactact     1860

caagaggagg acggctgttc atgccggttc ccagaggagg aggaaggcgg ctgcgaactg     1920

cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc     1980

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga     2040

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac     2100

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc     2160

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc     2220

tatgacgctc ttcacatgca ggccctgccg cctcgg                               2256


<210>  46
<211>  2241
<212>  DNA
<213>  ˹

<220>
<223>  TanCAR 04

<400>  46
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagcaagg       60

cctcaggtga cactgaggga gagcggaccc gccctggtga agcctaccca gacactgacc      120

ctgacatgca ccttcagcgg cgtgtccctg ccagactacg gcgtgagctg gatcaggcag      180

ccacctggca aggccctgga gtggctggcc gtgatctggg gctccgagac cacatactat      240

aactccgccc tgaagtctcg gctgaccatc agcaaggaca catccaagaa ccaggtggtg      300

ctgacaatga ccaatatgga ccctgtggat acagccacct actattgcgc caagcactac      360

tattacggcg gcagctatgc catggattac tggggccagg gcactacagt gaccgtgagc      420

tccggcggcg gcggctctgg aggaggagga tccggaggag gaggatccga gatcgtgctg      480

acccagtccc ctgccacact gagcctgtcc ccaggagaga gggccaccct gtcttgtaga      540

gccagccagg atatctccaa gtatctgaac tggtaccagc agaagccagg acaggcacca      600

aggctgctga tctatcacac ctctagactg cacagcggca tccccgacag gttctctgga      660

agcggatccg gcacagactt caccctgacc atcagcaggc tggagcccga ggacatcgcc      720

gtgtattact gccagcaggg caataccctg ccttacacat tcggccaggg aaccaagctg      780

gagatcgagg cagcagcaaa ggaggcagca gccaaggagg ccgccgccaa ggatatcgtg      840

atgacccagt ctccactgag cctgccagtg acaccaggag agcctgcctc tatcagctgt      900

cggtctagcc agtccctggt gcactctaac ggcaatacct ttctgcactg gtatctgcag      960

aagcctggcc agagcccaca gctgctgatc tacaaggtga gcaacaggtt ctccggcgtg     1020

cctgaccgct tttccggctc tggcagcggc accgatttca cactgaagat ctccagagtg     1080

gaggccgagg acgtgggcgt gtattactgc atgcagtcta cccacgtgct gacatttggc     1140

ggcggcacca agctggagat caagagggcc ggaggaggag gatctggagg aggaggcagc     1200

ggcggcggcg gctcccaggt gcagctggtg cagtccggag cagaggtgaa gaagccagga     1260

gcctctgtga aggtgagctg taaggcctcc ggctatacat tcaccgatta cctgatgcac     1320

tgggtgcgcc aggcaccagg acagggactg gagtggatgg gctggatcaa tacagagacc     1380

ggcgagccca cctatgccga cgacttcaag ggccgggtga caatgaccag agacacatcc     1440

acctctacag tgtacatgga gctgtcctct ctgcggtctg aggataccgc cgtgtattac     1500

tgtgccccct ctctgtatta cggctatagc tggtttacat attggggaca gggcaccctg     1560

gtgacagtgt ccaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1620

tcgcagcccc tgtccctgcg cccagaagcg tgccggccag cggcgggggg cgcagtgcac     1680

acgagggggc tggacttcgc ctgtgatatc tacatttggg cccctctggc tggtacttgc     1740

ggggtcctgc tgctttcact cgtgatcact ctttactgta agcgcggtcg gaagaagctg     1800

ctgtacatct ttaagcaacc cttcatgagg cctgtgcaga ctactcaaga ggaggacggc     1860

tgttcatgcc ggttcccaga ggaggaggaa ggcggctgcg aactgcgcgt gaaattcagc     1920

cgcagcgcag atgctccagc ctacaagcag gggcagaacc agctctacaa cgaactcaat     1980

cttggtcgga gagaggagta cgacgtgctg gacaagcgga gaggacggga cccagaaatg     2040

ggcgggaagc cgcgcagaaa gaatccccaa gagggcctgt acaacgagct ccaaaaggat     2100

aagatggcag aagcctatag cgagattggt atgaaagggg aacgcagaag aggcaaaggc     2160

cacgacggac tgtaccaggg actcagcacc gccaccaagg acacctatga cgctcttcac     2220

atgcaggccc tgccgcctcg g                                               2241


<210>  47
<211>  2196
<212>  DNA
<213>  ˹

<220>
<223>  TanCAR 05

<400>  47
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgccgccaga       60

cccgacatcg tgatgaccca gagcccactg tccctgcctg tgacaccagg agagcctgca      120

agcatctcct gcaggagctc ccagtccctg gtgcactcta acggcaatac cttcctgcac      180

tggtatctgc agaagccagg ccagagcccc cagctgctga tctacaaggt gagcaaccgg      240

ttctccggcg tgccagacag attttctggc agcggctccg gcaccgattt cacactgaag      300

atctccagag tggaggccga ggacgtgggc gtgtactatt gcatgcagtc tacccacgtg      360

ctgacatttg gcggcggcac caagctggag atcaagaggg ccggaggagg aggaagccag      420

gtgcagctgg tgcagtccgg agcagaggtg aagaagccag gagcctctgt gaaggtgagc      480

tgtaaggcct ccggctatac cttcacagat tacctgatgc actgggtgcg ccaggcacct      540

ggacagggac tggagtggat gggctggatc aataccgaga caggcgagcc aacctatgcc      600

gacgacttca agggccgggt gaccatgaca agagacacct ctacaagcac cgtgtacatg      660

gagctgtcta gcctgcggtc cgaggatacc gccgtgtact attgcgcccc ttccctgtac      720

tatggctatt cttggttcac atactggggc cagggcaccc tggtgacagt gtctggagga      780

ggaggaagcg gaggaggagg aagcggcggc ggcggctctg gcggcggcgg cagccaggtg      840

accctgaggg agagcggccc cgccctggtg aagcctacac agaccctgac actgacctgt      900

acattttctg gcgtgagcct gcccgattac ggcgtgtcct ggatcaggca gccacctggc      960

aaggccctgg agtggctggc cgtgatctgg ggcagcgaga ccacatacta taactctgcc     1020

ctgaagagcc ggctgaccat ctccaaggac acatctaaga accaggtggt gctgaccatg     1080

acaaatatgg accctgtgga taccgccaca tactattgcg ccaagcacta ctattacggc     1140

ggctcctatg ccatggatta ttggggacag ggcaccacag tgaccgtgtc ctctggagga     1200

ggaggatctg agatcgtgct gacccagagc cctgccacac tgtccctgtc tccaggagag     1260

agggccacac tgagctgtag ggcatcccag gacatctcta agtatctgaa ctggtaccag     1320

cagaagcctg gccaggcccc aaggctgctg atctatcaca ccagcaggct gcactccggc     1380

atccccgacc ggttcagcgg atccggatct ggcacagact tcaccctgac aatcagccgg     1440

ctggagccag aggatatcgc cgtgtattac tgtcagcagg gcaataccct gccctacaca     1500

tttggccagg gaactaagct ggagatcacc acgacgccag cgccgcgacc accaacaccg     1560

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aagcgtgccg gccagcggcg     1620

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ttgggcccct     1680

ctggctggta cttgcggggt cctgctgctt tcactcgtga tcactcttta ctgtaagcgc     1740

ggtcggaaga agctgctgta catctttaag caacccttca tgaggcctgt gcagactact     1800

caagaggagg acggctgttc atgccggttc ccagaggagg aggaaggcgg ctgcgaactg     1860

cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc     1920

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga     1980

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac     2040

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc     2100

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc     2160

tatgacgctc ttcacatgca ggccctgccg cctcgg                               2196


<210>  48
<211>  2196
<212>  DNA
<213>  ˹

<220>
<223>  TanCAR 06

<400>  48
atggccctgc cagtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagcaagg       60

cctcaggtga cactgaggga gagcggaccc gccctggtga agcctaccca gacactgacc      120

ctgacatgca ccttcagcgg cgtgtccctg ccagactacg gcgtgagctg gatcaggcag      180

ccacctggca aggccctgga gtggctggcc gtgatctggg gctccgagac cacatactat      240

aactccgccc tgaagtctcg gctgaccatc agcaaggata catccaagaa ccaggtggtg      300

ctgacaatga ccaatatgga ccccgtggat acagccacct actattgcgc caagcactac      360

tattacggcg gctcttatgc catggactac tggggccagg gcactacagt gaccgtgagc      420

agcggaggag gaggatccga tatcgtgatg acccagtctc ctctgagcct gccagtgaca      480

ccaggagagc ctgccagcat ctcctgtagg tctagccagt ctctggtgca cagcaacggc      540

aatacctttc tgcactggta tctgcagaag ccaggccaga gcccccagct gctgatctac      600

aaggtgtcca ataggttctc tggcgtgcca gaccgctttt ctggcagcgg ctccggcacc      660

gatttcacac tgaagatctc cagagtggag gccgaggacg tgggcgtgta ttactgcatg      720

cagtctaccc acgtgctgac atttggcggc ggcaccaagc tggagatcaa gagggccgga      780

ggaggaggat ctggaggagg aggcagcggc ggcggcggct ccggcggcgg cggctctcag      840

gtgcagctgg tgcagtccgg agcagaggtg aagaagccag gagccagcgt gaaggtgtcc      900

tgtaaggcct ctggctatac attcaccgat tacctgatgc actgggtgcg ccaggcacca      960

ggacagggac tggagtggat gggctggatc aacacagaga ccggcgagcc cacctatgcc     1020

gacgacttca agggccgggt gacaatgacc agagacacat ctaccagcac agtgtacatg     1080

gagctgtcct ctctgcggag cgaggatacc gccgtgtatt actgcgcccc ttctctgtat     1140

tacggctata gctggttcac atattgggga cagggcaccc tggtgacagt gagcggagga     1200

ggcggctccg agatcgtgct gacccagtcc cctgccacac tgtccctgtc tccaggagag     1260

agggccaccc tgagctgtag agcatcccag gacatctcta agtatctgaa ctggtaccag     1320

cagaagcctg gacaggcacc aaggctgctg atctatcaca ccagcagact gcactccggc     1380

atccccgaca ggttcagcgg atccggatct ggcacagact tcaccctgac aatcagccgg     1440

ctggagcccg aggatatcgc cgtgtattac tgtcagcagg gcaataccct gccttacaca     1500

tttggccagg gaactaagct ggagatcacc acgacgccag cgccgcgacc accaacaccg     1560

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aagcgtgccg gccagcggcg     1620

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ttgggcccct     1680

ctggctggta cttgcggggt cctgctgctt tcactcgtga tcactcttta ctgtaagcgc     1740

ggtcggaaga agctgctgta catctttaag caacccttca tgaggcctgt gcagactact     1800

caagaggagg acggctgttc atgccggttc ccagaggagg aggaaggcgg ctgcgaactg     1860

cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc     1920

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga     1980

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac     2040

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc     2100

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc     2160

tatgacgctc ttcacatgca ggccctgccg cctcgg                               2196


<210>  49
<211>  21
<212>  PRT
<213>  ˹

<220>
<223>  N-źĵİ

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  50
<211>  26
<212>  PRT
<213>  ˹

<220>
<223>  P2A

<400>  50

Arg Ala Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
1               5                   10                  15      


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      
            

<210>  51
<211>  1002
<212>  PRT
<213>  ˹

<220>
<223>  BiCAR

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
        195                 200                 205             


Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
    210                 215                 220                 


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe 
                245                 250                 255     


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Gly 
                485                 490                 495     


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
            500                 505                 510         


Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
        515                 520                 525             


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Thr Leu Arg Glu 
    530                 535                 540                 


Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys 
545                 550                 555                 560 


Thr Phe Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
                565                 570                 575     


Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Val Ile Trp Gly Ser 
            580                 585                 590         


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ser 
        595                 600                 605             


Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp 
    610                 615                 620                 


Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
625                 630                 635                 640 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
                645                 650                 655     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
        675                 680                 685             


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys 
    690                 695                 700                 


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
705                 710                 715                 720 


Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Asp Arg Phe Ser 
                725                 730                 735     


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
            740                 745                 750         


Pro Glu Asp Ile Ala Val Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro 
        755                 760                 765             


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Thr Thr Thr Pro Ala 
    770                 775                 780                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
785                 790                 795                 800 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                805                 810                 815     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            820                 825                 830         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        835                 840                 845             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    850                 855                 860                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
865                 870                 875                 880 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                885                 890                 895     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            900                 905                 910         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        915                 920                 925             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    930                 935                 940                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
945                 950                 955                 960 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                965                 970                 975     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            980                 985                 990         


Ala Leu His Met Gln Ala Leu Pro  Pro Arg 
        995                 1000         


<210>  52
<211>  3006
<212>  DNA
<213>  ˹

<220>
<223>  BiCAR

<400>  52
atggcgctgc cagtgaccgc gcttctgctg ccacttgcgc tgctgctgca cgccgcgcgc       60

cccgacatcg tgatgaccca gagccccctg tcgctgcctg tgactcccgg ggagccggcc      120

agcatttcgt gccggtcttc tcaatcgctg gttcacagta acggcaacac gttccttcac      180

tggtacctgc agaagcccgg ccagtccccg cagctgctga tctacaaggt gtcgaaccgt      240

ttctcgggcg tccccgacag gtttagcggc agcggttctg gtaccgattt cacccttaag      300

atatcccgcg tggaggccga ggacgtggga gtatactact gtatgcagtc cacccacgta      360

ctgaccttcg gcggcggcac aaagctggag atcaaaagag ctggaggcgg tggctcgggc      420

ggtggcggtt ctgggggcgg gggctctcag gtgcagctgg tgcagtccgg agctgaggtg      480

aagaagcctg gggcttccgt caaggtgtca tgcaaggctt ccggatacac cttcaccgac      540

tacctgatgc actgggtgcg ccaggctccg ggacagggac tggagtggat gggctggatt      600

aatacagaga ccggggagcc aacctacgcg gatgacttca agggccgtgt caccatgacg      660

cgtgacactt ctacttccac cgtgtacatg gagctgtcct ccctgcgctc ggaagacact      720

gccgtgtact actgtgctcc ttccctctat tacggctaca gctggttcac atattggggc      780

cagggtacct tggtcacggt cagtaccacg acccccgcac cccggccccc aacacctgct      840

cctaccatcg cctcccagcc gctctcgctg cgtccagagg cctgccgacc cgcggccggc      900

ggcgccgttc ataccagagg cttggatttc gcctgtgaca tctatatctg ggcacctcta      960

gctggcacct gcggggtgtt gctactgtct ctcgtgatca ccctgtactg taagcgcgga     1020

aggaagaagt tgctgtacat cttcaaacag cccttcatgc gtcccgtgca gaccacccag     1080

gaggaagacg gatgctcatg ccgattcccc gaggaagagg agggcggctg cgagctgcgt     1140

gtaaaatttt cccggtccgc ggacgcacct gcctacaagc agggtcagaa ccagttatac     1200

aacgagctca acctgggccg cagggaggag tacgatgtgc tggacaaacg ccgcggacgc     1260

gacccggaga tgggcggcaa gccgcgcagg aagaatccgc aggaggggct gtacaacgag     1320

ctacagaagg acaagatggc cgaggcgtac tccgagatcg gtatgaaagg agagcgccgc     1380

cgcggcaagg gccacgacgg cttgtatcaa ggtctgtcta ctgctaccaa ggacacctac     1440

gacgcccttc atatgcaggc cttgccccct cgccgcgcga agcgcggttc tggcgccacc     1500

aacttctccc tgctcaagca ggcaggtgat gtggaggaga atccagggcc gatggccctc     1560

cctgtcaccg ccctgctgct tccgctggct cttctgctcc acgccgctcg gccccaggtc     1620

accctgagag agagcggacc agccctggtg aaacctacac agaccctgac cctgacctgc     1680

acctttagcg gagtgtccct gccagactac ggagtgtctt ggatccggca gccaccagga     1740

aaagctctcg agtggctcgc agtgatttgg ggcagcgaga ccacctacta caacagcgcc     1800

ctgaagagca ggctgaccat cagcaaggac accagcaaga accaggtggt gctgaccatg     1860

accaacatgg accccgtgga caccgccacc tactattgcg ccaagcacta ctactacggc     1920

ggcagctacg ccatggacta ttggggacag ggcaccaccg tgacagtgtc tagcggagga     1980

ggaggaagcg gaggaggagg atctggagga ggaggcagcg agattgtgct gacacagagc     2040

ccagccacac tgtctctgag cccaggagag agagccacac tgtcttgcag ggccagccag     2100

gacatcagca agtacctgaa ttggtaccag cagaagcccg gccaggctcc taggctgctg     2160

atctaccaca ccagcaggct gcacagcggc atcccagaca gattcagcgg aagcggcagc     2220

ggcacagact tcaccctgac catcagcaga ctggagcccg aggacatcgc cgtgtactat     2280

tgccagcagg gcaacaccct gccctacacc tttggacagg gcaccaagct ggagatcacc     2340

actaccccag caccgaggcc acccaccccg gctcctacca tcgcctccca gcctctgtcc     2400

ctgcgtccgg aggcatgtag acccgcagct ggtggggccg tgcatacccg tggtcttgac     2460

ttcgcctgcg atatctacat ttgggcccct ctggctggta cttgcggggt cctgctgctt     2520

tcactcgtga tcactcttta ctgtaagcgc ggtcggaaga agctgctgta catctttaag     2580

caacccttca tgaggcctgt gcagactact caagaggagg acggctgttc atgccggttc     2640

ccagaggagg aggaaggcgg ctgcgaactg cgcgtgaaat tcagccgcag cgcagatgct     2700

ccagcctaca agcaggggca gaaccagctc tacaacgaac tcaatcttgg tcggagagag     2760

gagtacgacg tgctggacaa gcggagagga cgggacccag aaatgggcgg gaagccgcgc     2820

agaaagaatc cccaagaggg cctgtacaac gagctccaaa aggataagat ggcagaagcc     2880

tatagcgaga ttggtatgaa aggggaacgc agaagaggca aaggccacga cggactgtac     2940

cagggactca gcaccgccac caaggacacc tatgacgctc ttcacatgca ggccctgccg     3000

cctcgg                                                                3006


<210>  53
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  Դ-CD19 VL CDR2

<400>  53

His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
1               5                   10      


<210>  54
<211>  15
<212>  DNA
<213>  ˹

<220>
<223>  Linker1

<400>  54
ggaggaggag gaagc                                                        15


<210>  55
<211>  45
<212>  DNA
<213>  ˹

<220>
<223>  Linker2

<400>  55
ggaggaggag gaagcggagg aggaggaagc ggaggaggag gaagc                       45


<210>  56
<211>  60
<212>  DNA
<213>  ˹

<220>
<223>  Linker3

<400>  56
ggaggaggag gaagtggagg aggaggatcc ggcggcggcg gctctggcgg cggcggcagc       60


<210>  57
<211>  45
<212>  DNA
<213>  ˹

<220>
<223>  Linker4

<400>  57
gaggcagcag caaaggaggc agcagccaag gaggcagcag caaag                       45


<210>  58
<211>  63
<212>  DNA
<213>  ˹

<220>
<223>  N-źĵı

<400>  58
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccc                                                                     63


<210>  59
<211>  357
<212>  DNA
<213>  ˹

<220>
<223>  H-BCMA VH 

<400>  59
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc gactacctga tgcactgggt ccgacaggct      120

ccaggacaag gcttggaatg gatgggctgg atcaacaccg agacaggcga gcctacctac      180

gccgacgatt tcaagggcag agtgaccatg accagagaca ccagcacctc caccgtgtac      240

atggaactga gcagcctgag aagcgaggac accgccgtgt actactgtgc ccctagcctg      300

tactacggct actcctggtt tacctactgg ggccagggca ccctggtcac agtttct         357


<210>  60
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  H-BCMA VL

<400>  60
gacatcgtga tgacacagag ccctctgagc ctgcctgtga cacctggcga acctgccagc       60

atcagctgta gaagcagcca gagcctggtg cacagcaacg gcaatacctt cctgcactgg      120

tatctgcaga agcccggcca gtctcctcag ctgctgatct acaaggtgtc caaccggttc      180

agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgta tgcagagcac ccacgtgctg      300

acctttggcg gcggaacaaa gctggaaatc aagcgggct                             339


<210>  61
<211>  360
<212>  DNA
<213>  ˹

<220>
<223>  H-CD19 VH

<400>  61
caggtcaccc tgagagagag cggaccagcc ctggtgaaac ctacacagac cctgaccctg       60

acctgcacct ttagcggagt gtccctgcca gactacggag tgtcttggat ccggcagcca      120

ccaggaaaag ctctcgagtg gctcgcagtg atttggggca gcgagaccac ctactacaac      180

agcgccctga agagcaggct gaccatcagc aaggacacca gcaagaacca ggtggtgctg      240

accatgacca acatggaccc cgtggacacc gccacctact attgcgccaa gcactactac      300

tacggcggca gctacgccat ggactattgg ggacagggca ccaccgtgac agtgtctagc      360


<210>  62
<211>  318
<212>  DNA
<213>  ˹

<220>
<223>  H-CD19 VL

<400>  62
gagattgtgc tgacacagag cccagccaca ctgtctctga gcccaggaga gagagccaca       60

ctgtcttgca gggccagcca ggacatcagc aagtacctga attggtacca gcagaagccc      120

ggccaggctc ctaggctgct gatctaccac accagcaggc tgcacagcgg catcccagac      180

agattcagcg gaagcggcag cggcacagac ttcaccctga ccatcagcag actggagccc      240

gaggacatcg ccgtgtacta ttgccagcag ggcaacaccc tgccctacac ctttggacag      300

ggcaccaagc tggagatc                                                    318


<210>  63
<211>  423
<212>  DNA
<213>  ˹

<220>
<223>  SFFV

<400>  63
agctagctgc agtaacgcca ttttgcaagg catggaaaaa taccaaacca agaatagaga       60

agttcagatc aagggcgggt acatgaaaat agctaacgtt gggccaaaca ggatatctgc      120

ggtgagcagt ttcggccccg gcccggggcc aagaacagat ggtcaccgca gtttcggccc      180

cggcccgagg ccaagaacag atggtcccca gatatggccc aaccctcagc agtttcttaa      240

gacccatcag atgtttccag gctcccccaa ggacctgaaa tgaccctgcg ccttatttga      300

attaaccaat cagcctgctt ctcgcttctg ttcgcgcgct tctgcttccc gagctctata      360

aaagagctca caacccctca ctcggcgcgc cagtcctccg acagactgag tcgcccgggt      420

acc                                                                    423


<210>  64
<211>  755
<212>  PRT
<213>  ˹

<220>
<223>  TanCAR08

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
        195                 200                 205             


Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
    210                 215                 220                 


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe 
                245                 250                 255     


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    290                 295                 300                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Val Ser Leu Pro Asp Tyr 
305                 310                 315                 320 


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
                325                 330                 335     


Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
            340                 345                 350         


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
        355                 360                 365             


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
    370                 375                 380                 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                405                 410                 415     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Ile Val Leu Thr Gln 
            420                 425                 430         


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        435                 440                 445             


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu 
465                 470                 475                 480 


His Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                485                 490                 495     


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ile Ala Val Tyr 
            500                 505                 510         


Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr 
        515                 520                 525             


Lys Leu Glu Ile Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    530                 535                 540                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
545                 550                 555                 560 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                565                 570                 575     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            580                 585                 590         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        595                 600                 605             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    610                 615                 620                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
625                 630                 635                 640 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                645                 650                 655     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            660                 665                 670         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        675                 680                 685             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    690                 695                 700                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
705                 710                 715                 720 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                725                 730                 735     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            740                 745                 750         


Pro Pro Arg 
        755 


<210>  65
<211>  2265
<212>  DNA
<213>  ˹

<220>
<223>  TanCAR08

<400>  65
atggcgttgc ccgtgaccgc tctcctgttg cctctagctc tgctattaca cgccgcgagg       60

cccgacatcg tgatgacgca gagcccgctt tcgttaccgg taacacccgg cgaacctgct      120

tccatttcgt gccgatcttc tcaatccctt gtccactcca acggcaacac gttcctgcat      180

tggtacctgc agaagcctgg tcagagccct cagctgttga tctacaaggt gagcaaccgc      240

ttctccggtg tccccgacag gtttagcgga tccggatcag ggaccgattt caccctgaag      300

atctctcgtg tggaggcaga ggatgtgggc gtgtactact gtatgcaatc cactcacgtg      360

ctgactttcg gaggcggcac caagctggag atcaagcggg ccggcggtgg aggctcgggc      420

gggggtggtt ccgggggcgg cggtagccaa gtccagctgg tgcagtccgg cgcggaggtg      480

aaaaaacctg gcgcctccgt aaaggttagc tgcaaggcct ctggctacac cttcaccgac      540

tacctgatgc actgggtgag acaggctccc ggccagggac tggagtggat ggggtggatt      600

aataccgaga ctggggaacc aacgtatgcg gatgacttca aaggccgtgt cactatgacc      660

cgcgacactt ccaccagcac cgtgtacatg gagctgtcat ctctgaggtc cgaggacacc      720

gccgtgtatt actgtgctcc ctctctttac tacggttaca gttggttcac ctattggggc      780

cagggcacgc tggttaccgt aagcggtggg ggcggatccg gcggcggcgg ctcaggcggc      840

ggtggctctg gtggcggagg ttcccaggtg accctgcgcg agagcgggcc agcactggtg      900

aagccaaccc agactctgac cctgacctgc actttctcag gcgtgtcctt gcctgattac      960

ggcgtcagtt ggatccgcca gcccccagga aaagctctcg agtggctagc ggtgatctgg     1020

ggctccgaaa cgacctacta caacagcgcc ctcaagagtc gcctcacaat ttccaaggac     1080

acctccaaga accaggtggt gctgacgatg accaacatgg acccggtgga caccgctaca     1140

tactattgtg cgaagcacta ctactacggc gggagctacg ccatggacta ttggggacag     1200

ggcaccaccg tcaccgtttc aagtgggtcc accagcggct ccggcaaacc gggctccggg     1260

gagggctcca ccaagggaga gattgtcctg acccagagcc cggctactct tagtctgtca     1320

ccgggcgagc gcgccaccct gtcttgtaga gcctctcagg acatctccaa gtacttgaac     1380

tggtaccagc agaagccggg acaggcgcct cgcttactga tttaccacac aagccgactc     1440

cactccggca tccccgaccg cttctctggg tctggctcgg gcactgattt caccctgacg     1500

atctcccgcc tggagccaga agatatcgcc gtgtactact gtcaacaggg caatacgctg     1560

ccctatacgt ttgggcaggg cactaagctc gagatcacca caacccctgc gccgcgccct     1620

ccgacccccg cccccaccat cgctagccag ccgctgtctc tgcgccccga ggcctgcagg     1680

cccgcggcgg gaggtgctgt gcatacacgc gggctcgatt ttgcttgcga catctatata     1740

tgggcacccc tggcagggac ctgcggggtg ctgctgctga gcttggtgat caccctttac     1800

tgtaagcggg gccgcaagaa gttgctctac atcttcaagc agcccttcat gcgcccggtg     1860

cagacgaccc aggaggaaga cgggtgctct tgtcgttttc ccgaagagga ggagggcggt     1920

tgcgagctgc gcgtcaaatt ttctcgctcg gccgacgccc ctgcctatca gcagggccag     1980

aaccagttgt acaacgagct taacctgggt cggcgtgagg agtacgacgt gctggacaag     2040

cgccgtggtc gtgatccaga gatgggcggc aagccccgtc gcaagaatcc acaggagggg     2100

ctttacaacg agctgcagaa ggacaaaatg gctgaggcct actccgagat cggaatgaag     2160

ggtgagcggc ggcgcggcaa gggccatgac ggcctttacc agggcctctc gactgccact     2220

aaagacactt acgacgctct gcacatgcag gccctgcccc ctcgc                     2265


<210>  66
<211>  726
<212>  PRT
<213>  ˹

<220>
<223>  TanCAR10

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Phe Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Thr His Val Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Leu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
        195                 200                 205             


Tyr Ala Asp Asp Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
    210                 215                 220                 


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Pro Ser Leu Tyr Tyr Gly Tyr Ser Trp Phe 
                245                 250                 255     


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
    290                 295                 300                 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
305                 310                 315                 320 


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
                325                 330                 335     


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
            340                 345                 350         


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
        355                 360                 365             


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
    370                 375                 380                 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
385                 390                 395                 400 


Gly Thr Ser Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                405                 410                 415     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln 
            420                 425                 430         


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
        435                 440                 445             


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
    450                 455                 460                 


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
465                 470                 475                 480 


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                485                 490                 495     


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
            500                 505                 510         


Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
        515                 520                 525             


Lys Leu Glu Ile Thr Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    530                 535                 540                 


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
545                 550                 555                 560 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
                565                 570                 575     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            580                 585                 590         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        595                 600                 605             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    610                 615                 620                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
625                 630                 635                 640 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                645                 650                 655     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            660                 665                 670         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        675                 680                 685             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    690                 695                 700                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
705                 710                 715                 720 


Gln Ala Leu Pro Pro Arg 
                725     


<210>  67
<211>  2178
<212>  DNA
<213>  ˹

<220>
<223>  TanCAR10

<400>  67
atggccctgc ccgtcaccgc cctattactg ccgctggcgc tcctgctgca cgcggcgcgg       60

ccggatatcg tgatgaccca gagccccctc tccctaccgg tgacacctgg ggagcctgcg      120

tcgatctcct gtcgctcgtc ccaatctttg gtgcactcaa atggcaacac gttcctccat      180

tggtacttgc agaagcccgg gcagagccct cagctgctca tctacaaggt tagcaaccgc      240

ttttctggcg tgcctgaccg cttcagtgga tcgggatcag gaaccgactt cactctgaag      300

atatccagag tagaggccga ggatgtgggc gtgtactact gtatgcagtc tacgcatgta      360

ctgaccttcg gcgggggcac taagctggag atcaagcgcg ccggcggcgg cggttcgggg      420

ggtggtggtt ctgggggcgg cggctcccag gtccagttgg tgcagagcgg ggctgaggtt      480

aagaagccgg gcgcttctgt caaggtgtcc tgcaaagcaa gcggctacac cttcaccgac      540

tacctcatgc actgggtcag acaggccccc ggacaggggc tggaatggat gggatggatt      600

aacacggaga ccggcgagcc aacctacgcg gacgatttca aggggcgggt aacgatgacc      660

cgcgacactt ccacttctac cgtgtacatg gagctgtcct ccctgcgctc tgaagatact      720

gccgtgtact actgtgctcc ttcactttat tatggctatt cttggtttac gtattggggc      780

cagggaaccc tggtcaccgt ttccggaggc ggggggtccg gaggaggcgg ctctggtggg      840

ggaggtagcg gcggtggcgg atcggaggtg aagctgcaag agtctgggcc cggtctagtg      900

gctcccagtc agtcgcttag cgtcacctgc acagtgtcag gcgtgtccct gcccgactac      960

ggcgtttcct ggatccgcca gccacccagg aagggtttgg agtggctggg tgtgatctgg     1020

ggctccgaga ctacttacta caactccgct ctgaagtccc gtctgacaat tatcaaagac     1080

aactccaagt cgcaggtgtt cctgaaaatg aacagcctgc agacagatga cactgccatc     1140

tattactgtg ccaagcacta ctactacggc ggtagctacg ccatggatta ttggggccag     1200

ggcacctccg tgaccgtgag tagcgggtct acttccggat caggtaagcc cggctcgggt     1260

gagggctcca cgaagggtga tatccagatg acccagacta ccagctcctt gtctgcatcg     1320

ctgggcgaca gggtgaccat cagctgccga gctagccagg acatctccaa gtacctcaac     1380

tggtaccagc agaagcccga cggcaccgtc aagcttctta tttaccatac cagccgcctg     1440

cacagtggtg tcccgtcccg cttctccggc agcgggtccg gaaccgacta ctctctgacc     1500

atctccaacc tggaacagga ggacatcgcc acctatttct gtcagcaggg taatacatta     1560

ccctatacct tcggtggcgg cactaaactg gagatcaccg agagtaagta cggccctccc     1620

tgcccaccct gcccattttg ggtcctggtg gtggtcggtg gcgttttggc ctgttacagc     1680

ttgctggtga ccgtggcatt cattattttt tgggtcaagc gcggccgcaa aaagctgtta     1740

tacatcttca aacagccgtt catgcgtccg gtgcagacga cccaggagga ggacggctgc     1800

tcttgccggt tccccgagga ggaggagggc ggctgcgaac tgcgcgtgaa attttctcgc     1860

agcgccgacg ccccggccta caagcagggc cagaaccagc tgtacaacga gttgaacctg     1920

ggccgtcggg aagagtacga cgtgctggac aaaagacgcg gtcgcgaccc tgagatgggc     1980

ggaaagcctc gccgaaagaa tccacaggag ggcctctaca acgaactcca gaaggacaag     2040

atggcggagg catacagcga gatcggtatg aaaggcgagc gccgtcgtgg gaagggccac     2100

gacggcctgt accaaggcct gtccaccgct accaaggaca cctacgatgc gctccacatg     2160

caggctcttc ctccgagg                                                   2178


<210>  68
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  Linker 5

<400>  68

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  69
<211>  54
<212>  DNA
<213>  ˹

<220>
<223>  Linker5 

<400>  69
gggtctactt ccggatcagg taagcccggc tcgggtgagg gctccacgaa gggt             54


<210>  70
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  IgG4Hinge

<400>  70

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  71
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  IgG4Hinge

<400>  71
gagagtaagt acggccctcc ctgcccaccc tgccca                                 36


<210>  72
<211>  27
<212>  PRT
<213>  ˹

<220>
<223>  CD28TM

<400>  72

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  73
<211>  81
<212>  DNA
<213>  ˹

<220>
<223>  CD28TM

<400>  73
ttttgggtcc tggtggtggt cggtggcgtt ttggcctgtt acagcttgct ggtgaccgtg       60

gcattcatta ttttttgggt c                                                 81


<210>  74
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  CD3ưźŴṹ򰱻-2

<400>  74

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  75
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  CD3ưźŴṹ-2

<400>  75
cgcgtcaaat tttctcgctc ggccgacgcc cctgcctatc agcagggcca gaaccagttg       60

tacaacgagc ttaacctggg tcggcgtgag gagtacgacg tgctggacaa gcgccgtggt      120

cgtgatccag agatgggcgg caagccccgt cgcaagaatc cacaggaggg gctttacaac      180

gagctgcaga aggacaaaat ggctgaggcc tactccgaga tcggaatgaa gggtgagcgg      240

cggcgcggca agggccatga cggcctttac cagggcctct cgactgccac taaagacact      300

tacgacgctc tgcacatgca ggccctgccc cctcgc                                336


<210>  76
<211>  120
<212>  PRT
<213>  ˹

<220>
<223>  Դ-CD19 VH

<400>  76

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  77
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  Դ-CD19 VL

<400>  77

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  78
<211>  360
<212>  DNA
<213>  ˹

<220>
<223>  Դ-CD19 VH

<400>  78
gaggtgaagc tgcaagagtc tgggcccggt ctagtggctc ccagtcagtc gcttagcgtc       60

acctgcacag tgtcaggcgt gtccctgccc gactacggcg tttcctggat ccgccagcca      120

cccaggaagg gtttggagtg gctgggtgtg atctggggct ccgagactac ttactacaac      180

tccgctctga agtcccgtct gacaattatc aaagacaact ccaagtcgca ggtgttcctg      240

aaaatgaaca gcctgcagac agatgacact gccatctatt actgtgccaa gcactactac      300

tacggcggta gctacgccat ggattattgg ggccagggca cctccgtgac cgtgagtagc      360


<210>  79
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  Դ-CD19 VL

<400>  79
gatatccaga tgacccagac taccagctcc ttgtctgcat cgctgggcga cagggtgacc       60

atcagctgcc gagctagcca ggacatctcc aagtacctca actggtacca gcagaagccc      120

gacggcaccg tcaagcttct tatttaccat accagccgcc tgcacagtgg tgtcccgtcc      180

cgcttctccg gcagcgggtc cggaaccgac tactctctga ccatctccaa cctggaacag      240

gaggacatcg ccacctattt ctgtcagcag ggtaatacat taccctatac cttcggtggc      300

ggcactaaac tggagatcac c                                                321


<210>  80
<211>  486
<212>  PRT
<213>  ˹

<220>
<223>  FMC63 CAR  ȫ

<400>  80

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  81
<211>  1458
<212>  DNA
<213>  ˹

<220>
<223>  FMC63 CAR

<400>  81
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccactacccc agcaccgagg ccacccaccc cggctcctac catcgcctcc      840

cagcctctgt ccctgcgtcc ggaggcatgt agacccgcag ctggtggggc cgtgcatacc      900

cggggtcttg acttcgcctg cgatatctac atttgggccc ctctggctgg tacttgcggg      960

gtcctgctgc tttcactcgt gatcactctt tactgtaagc gcggtcggaa gaagctgctg     1020

tacatcttta agcaaccctt catgaggcct gtgcagacta ctcaagagga ggacggctgt     1080

tcatgccggt tcccagagga ggaggaaggc ggctgcgaac tgcgcgtgaa attcagccgc     1140

agcgcagatg ctccagccta caagcagggg cagaaccagc tctacaacga actcaatctt     1200

ggtcggagag aggagtacga cgtgctggac aagcggagag gacgggaccc agaaatgggc     1260

gggaagccgc gcagaaagaa tccccaagag ggcctgtaca acgagctcca aaaggataag     1320

atggcagaag cctatagcga gattggtatg aaaggggaac gcagaagagg caaaggccac     1380

gacggactgt accagggact cagcaccgcc accaaggaca cctatgacgc tcttcacatg     1440

caggccctgc cgcctcgg                                                   1458



