                         SEQUENCE LISTING

<110>  Northwestern University
       Jin, Jing
       Liu, Pan
 
<120>  HUMAN RECOMBINANT ACE2-FC MUTANTS THAT DECOUPLE ANTI-SARS-COV-2 
       ACTIVITY FROM CARDIOVASCULAR EFFECTS

<130>  702581.01988

<150>  US 63/047,741
<151>  2020-07-02

<150>  US 63/065,458
<151>  2020-08-13

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  2
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser 
        


<210>  3
<211>  601
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys 
        595                 600     


<210>  4
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  5
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising E145A Mutation

<400>  5

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Ala Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  6
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising R273A Mutation

<400>  6

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Ala Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  7
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising H345 Mutation

<400>  7

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys Ala Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  8
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising P346 Mutation

<400>  8

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Ala Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  9
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising D368 Mutation

<400>  9

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Ala Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  10
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising H374 Mutation

<400>  10

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His Ala Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  11
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising H378 Mutation

<400>  11

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly Ala Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  12
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising E402 Mutation

<400>  12

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Ala 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  13
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Human ACE2 Comprising H505 Mutation

<400>  13

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe Ala Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    530                 535         


<210>  14
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  15
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  15

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Ala Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  16
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  16

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Ala Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  17
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  17

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys Ala Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  18
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  18

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Ala Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  19
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  19

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Ala Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  20
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  20

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His Ala Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  21
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  21

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly Ala Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  22
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  22

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Ala 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


<210>  23
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein Between ACE2 Variant and Fc

<400>  23

Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      


Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          


Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              


Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  


Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys 
                85                  90                  95      


Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly 
            100                 105                 110         


Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro 
        115                 120                 125             


Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu 
    130                 135                 140                 


Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro 
145                 150                 155                 160 


Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn 
                165                 170                 175     


His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn 
            180                 185                 190         


Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val 
        195                 200                 205             


Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala 
    210                 215                 220                 


Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro 
225                 230                 235                 240 


Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe 
                245                 250                 255     


Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn 
            260                 265                 270         


Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg 
        275                 280                 285             


Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn 
    290                 295                 300                 


Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
305                 310                 315                 320 


Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
                325                 330                 335     


Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu 
            340                 345                 350         


Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala 
        355                 360                 365             


Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu 
    370                 375                 380                 


Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu 
385                 390                 395                 400 


Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr 
                405                 410                 415     


Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu 
            420                 425                 430         


Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly 
        435                 440                 445             


Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg 
    450                 455                 460                 


Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys 
465                 470                 475                 480 


Asp Pro Ala Ser Leu Phe Ala Val Ser Asn Asp Tyr Ser Phe Ile Arg 
                485                 490                 495     


Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys 
            500                 505                 510         


Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn 
        515                 520                 525             


Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys 
    530                 535                 540                 


Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn 
545                 550                 555                 560 


Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp 
                565                 570                 575     


Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp 
            580                 585                 590         


Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser 
        595                 600                 605             


Ala Leu Gly Asp Arg Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu 
    610                 615                 620                 


Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val 
625                 630                 635                 640 


Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn 
                645                 650                 655     


Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn 
            660                 665                 670         


Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met 
        675                 680                 685             


Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu 
    690                 695                 700                 


Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro 
705                 710                 715                 720 


Val Ser Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                725                 730                 735     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            740                 745                 750         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        755                 760                 765             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    770                 775                 780                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
785                 790                 795                 800 


Arg Glu Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                805                 810                 815     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            820                 825                 830         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        835                 840                 845             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    850                 855                 860                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
865                 870                 875                 880 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                885                 890                 895     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            900                 905                 910         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        915                 920                 925             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    930                 935                 940                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
945                 950                 955                 960 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970                 


